Open access peer-reviewed Edited Volume

Synthetic Genomics - From Natural to Synthetic Genomes

Miguel Fernández-Niño

Leibniz-Institut für Pflanzenbiochemie

Dr. Miguel Fernández-Niño obtained his Ph.D. in Biochemical Engineering from the Jacobs University Bremen, Germany. He is an experienced researcher in synthetic biology, genetic engineering, and molecular biotechnology.


Luis H. Reyes

Universidad de Los Andes

Luis H. Reyes obtained his Ph.D. in Chemical Engineering at Texas A&M University, USA. He received the Director's Fellowship at the National Renewable Energy Laboratory, NREL, USA, where he did a postdoc in the Biosciences Center developing a Clostridium thermocellum strain towards the New Generation of Consolidated Bioprocessing.


Enzymatic DNA Synthesis Chemical DNA Synthesis Codon Optimization BioBricks Design Ligation-Mediated Assembly PCR-Mediated Assembly Organisms Rational Modification CRISPR-Cas9 Metabolic Network Modelling Unnatural Base Pairs Hachimoji DNA Synthetic Nucleobases

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About the book

During the last ten years, several technologies have evolved to allow the design and assembly of novel-unnatural biological systems, which is one of the main goals of synthetic biology. Currently, we are moving into a new wave of synthetic biology where building blocks for metabolic engineering can be designed and synthesized at an accessible price. This book aims to summarize the most recent advances on artificial gene synthesis such as enzymatic DNA synthesis, Chemical DNA synthesis, and High-Throughput Gene Synthesis, which are essential tools for the rational engineering of artificial metabolic pathways. Here, we will also discuss how the structural building blocks for metabolic engineering (Biobricks) can be obtained through a rational design process to ease pathway assembly. Thus, the state-of-the-art of several assembly methodologies such as Ligation-mediated assembly, PCR-mediated assembly, and Modular metabolic engineering will be discussed. Finally, a brief description of the most recent technologies to expand life's vocabulary through the construction of artificial nucleotides and their impact on research and industry will also be included in this book.

Publishing process

Book initiated and editor appointed

Date completed: March 4th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: May 31st 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: August 19th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: October 18th 2021

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About the editor

Miguel Fernández-Niño

Leibniz-Institut für Pflanzenbiochemie

Dr. Miguel Fernández-Niño is a biologist from the National University of Colombia with a Master\'s Degree in Biochemistry from the same institution and a Ph.D. in Biochemical Engineering from the Jacobs University Bremen (Germany). He is currently working as a researcher at the Leibniz Institute of Plant Biochemistry (Germany). Dr. Fernández-Niño has extensive experience in synthetic biology, genetic engineering, molecular biotechnology, microfluidic analysis, Quorum Sensing, and cell-cell heterogeneity.

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