Risk factors for gallbladder stone diseases.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7144",leadTitle:null,fullTitle:"Veterinary Anatomy and Physiology",title:"Veterinary Anatomy and Physiology",subtitle:null,reviewType:"peer-reviewed",abstract:"Knowledge of veterinary anatomy and physiology is essential for veterinary professionals and researchers. The chapters reflect the diverse and dynamic research being undertaken in a variety of different species throughout the world. Whether the animals have roles in food security, agriculture, or as companion, wild, or working animals, the lessons we learn impact on many areas of the profession. This book highlights research ranging from the cardiovascular and musculoskeletal systems, prostate and hoof, through to histopathology, imaging, and molecular techniques. It investigates both healthy and pathological conditions at differing stages of life. The importance of each cell and tissue through to the whole organism is explored alongside the methodologies used to understand these vital structures and functions.",isbn:"978-1-78985-706-1",printIsbn:"978-1-78985-705-4",pdfIsbn:"978-1-83962-072-0",doi:"10.5772/intechopen.73942",price:119,priceEur:129,priceUsd:155,slug:"veterinary-anatomy-and-physiology",numberOfPages:168,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"75cdacb570e0e6d15a5f6e69640d87c9",bookSignature:"Catrin Sian Rutland and Valentina Kubale",publishedDate:"March 13th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7144.jpg",numberOfDownloads:13805,numberOfWosCitations:13,numberOfCrossrefCitations:11,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:19,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:43,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 28th 2018",dateEndSecondStepPublish:"June 18th 2018",dateEndThirdStepPublish:"August 17th 2018",dateEndFourthStepPublish:"November 5th 2018",dateEndFifthStepPublish:"January 4th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"10",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Ljubljana",institutionURL:null,country:{name:"Slovenia"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"25",title:"Veterinary Medicine and Science",slug:"veterinary-medicine-and-science"}],chapters:[{id:"65366",title:"Introductory Chapter: Veterinary Anatomy and Physiology",doi:"10.5772/intechopen.82412",slug:"introductory-chapter-veterinary-anatomy-and-physiology",totalDownloads:1860,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:null,signatures:"Valentina Kubale, Emma Cousins, Clara Bailey, Samir A.A. El-Gendy\nand Catrin Sian Rutland",downloadPdfUrl:"/chapter/pdf-download/65366",previewPdfUrl:"/chapter/pdf-preview/65366",authors:[{id:"202192",title:"Dr.",name:"Catrin",surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland"},{id:"246149",title:"Dr.",name:"Valentina",surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale"},{id:"283315",title:"Prof.",name:"Samir",surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy"},{id:"283317",title:"BSc.",name:"Emma",surname:"Cousins",slug:"emma-cousins",fullName:"Emma Cousins"},{id:"283318",title:"BSc.",name:"Clara",surname:"Bailey",slug:"clara-bailey",fullName:"Clara Bailey"}],corrections:null},{id:"65570",title:"The Anatomy, Histology and Physiology of the Healthy and Lame Equine Hoof",doi:"10.5772/intechopen.84514",slug:"the-anatomy-histology-and-physiology-of-the-healthy-and-lame-equine-hoof",totalDownloads:2092,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:1,abstract:"Satisfactory investigations of the equine foot appear to be limited by the histo-morphological complexity of internal hoof structures. Foot lameness is considered to be one of the most debilitating pathological disorders of the equine foot. In most species, foot lameness is traditionally linked to hoof deformity, and a set of molecular events have been defined in relation to the disease. So far, there is controversy regarding the incidence of foot lameness in horses, as it is unclear whether it is foot lameness that triggers hoof distortions or vice-versa. In order to develop a better understanding of foot lameness, we review both the healthy and lame foot anatomy, cell biology and vascularisation and using micro-computed tomography show new methods of visualising internal structures within the equine foot.",signatures:"Ramzi Al-Agele, Emily Paul, Valentina Kubale Dvojmoc, Craig J. Sturrock,\nCyril Rauch and Catrin Sian Rutland",downloadPdfUrl:"/chapter/pdf-download/65570",previewPdfUrl:"/chapter/pdf-preview/65570",authors:[{id:"202192",title:"Dr.",name:"Catrin",surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland"},{id:"246149",title:"Dr.",name:"Valentina",surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale"},{id:"261698",title:"Dr.",name:"Ramzi",surname:"Al-Agele",slug:"ramzi-al-agele",fullName:"Ramzi Al-Agele"},{id:"261699",title:"MSc.",name:"Emily",surname:"Paul",slug:"emily-paul",fullName:"Emily Paul"},{id:"261701",title:"Prof.",name:"Cyril",surname:"Rauch",slug:"cyril-rauch",fullName:"Cyril Rauch"},{id:"276603",title:"Mr.",name:"Craig",surname:"Sturrock",slug:"craig-sturrock",fullName:"Craig Sturrock"}],corrections:null},{id:"63901",title:"Macroscopic, Radiographic and Histopathologic Changes of Claws with Laminitis and Laminitis-Related Disorders in Zero-Grazed Dairy Cows",doi:"10.5772/intechopen.81255",slug:"macroscopic-radiographic-and-histopathologic-changes-of-claws-with-laminitis-and-laminitis-related-d",totalDownloads:1014,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Laminitis and laminitis-related claw disorders are prevalent in zero-grazed dairy cows. Confinement and limited movement influences claw size and shape. Abnormal claw size and shape causes imbalanced body weight distribution on the claws. Claw horn growth and wear is impaired, further aggravating laminitis disorders. The objective of this study was to determine: macroscopic disorders on the claws, as well as radiographic features and histopathologic changes on the claws with laminitis/laminitis-related disorders. A total of 159 dairy cow forelimb and hind limb feet (318 claws) were collected from an abattoir and a slaughter slab around Nairobi, Kenya. The claws were examined for macroscopic abnormalities, dorso-palmar or dorso-plantar radiography done, sagittal claw sections done, corium gross changes observed and corium tissues harvested for histopathology. Macroscopic disorders observed were: sole bruising, claw deformities, heel erosion, subclinical laminitis sole haemorrhages, double soles, chronic laminitis and white line separation. Radiographic changes observed mainly on distal phalanges were dilated vascular channels, irregular margins, exostoses/periostitis, distal phalangeal narrowing and lysis. Histopathologic changes in the corium included arterio-venous shunts, vascular wall rupture and thickening, vascular proliferation and thrombosis, corium and connective tissue oedema, degeneration, haemorrhages and spongiosis. Hence macroscopic, radiographic and histopathologic changes in laminitis claws affect locomotion.",signatures:"James Nguhiu-Mwangi and Peter M.F. Mbithi",downloadPdfUrl:"/chapter/pdf-download/63901",previewPdfUrl:"/chapter/pdf-preview/63901",authors:[{id:"262330",title:"Prof.",name:"James",surname:"Nguhiu-Mwangi",slug:"james-nguhiu-mwangi",fullName:"James Nguhiu-Mwangi"},{id:"271483",title:"Prof.",name:"Peter",surname:"Mbithi",slug:"peter-mbithi",fullName:"Peter Mbithi"}],corrections:null},{id:"63726",title:"Myocardial Metabolism",doi:"10.5772/intechopen.80870",slug:"myocardial-metabolism",totalDownloads:1464,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Myocardial metabolism alterations are associated with myocardial dystrophy and lead to the heart chambers dilatation, decreased contractility, organs perfusion and depended on symptoms. Nowadays heart failure treatment in veterinary medicine includes neurohormonal, circulatory and contractile aspects of this pathological state. Unfortunately, energy supplying component not presented in modern recommendations. Most of the used medications changing contractile ability, through the control of myocardial filaments sensibility to the different ions, but don’t affect the ability of cardiomyocytes to produce enough energy for this work. In order to understand the heart failure syndrome more completely, we should elucidate features, characteristics, and interactions between components of myocardial energy supply.",signatures:"Dmitrii Oleinikov",downloadPdfUrl:"/chapter/pdf-download/63726",previewPdfUrl:"/chapter/pdf-preview/63726",authors:[{id:"260411",title:"Dr.",name:"Dmitrii",surname:"Oleinikov",slug:"dmitrii-oleinikov",fullName:"Dmitrii Oleinikov"}],corrections:null},{id:"63889",title:"Anatomy, Histology, and Physiology of the Canine Prostate Gland",doi:"10.5772/intechopen.81410",slug:"anatomy-histology-and-physiology-of-the-canine-prostate-gland",totalDownloads:2015,totalCrossrefCites:5,totalDimensionsCites:7,hasAltmetrics:0,abstract:"The prostate gland is the only male accessory gland in dogs and is responsible for secreting the prostatic fluid. Morphologically, the canine prostate gland lacks differentiation into zones, presenting a uniform parenchyma along the longitudinal axis. The luminal epithelial cells secrete a liquid rich in calcium, citric acid, simple sugars, and different enzymes as a component of the seminal plasma. Since the prostatic diseases are very common in small animal practice, there are many information regarding mechanisms of the different prostatic conditions and lack of information regarding the anatomy, histology, and physiology of the canine prostate gland. Thus, this chapter aims to meticulously describe the anatomy, histology, and physiology of the canine prostate gland.",signatures:"Antonio Fernando Leis-Filho and Carlos E. Fonseca-Alves",downloadPdfUrl:"/chapter/pdf-download/63889",previewPdfUrl:"/chapter/pdf-preview/63889",authors:[{id:"258334",title:"Dr.",name:"Carlos Eduardo",surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves"},{id:"266102",title:"MSc.",name:"Antonio Fernando",surname:"Leis Filho",slug:"antonio-fernando-leis-filho",fullName:"Antonio Fernando Leis Filho"}],corrections:null},{id:"64559",title:"Major Health Constraints and Ethno-Vet Practices of Small-Scale and Backyard Chicken Production in Some Selected Regions of Ethiopia",doi:"10.5772/intechopen.81302",slug:"major-health-constraints-and-ethno-vet-practices-of-small-scale-and-backyard-chicken-production-in-s",totalDownloads:1001,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A study was conducted with the aim of assessing the major health constraints facing the small-scale and backyard chicken producers and ethno-vet practices exercised in five regions of the country: Amhara, Benishangul-Gumuz, Oromia, Southern region, and Tigray. Household respondents were purposively selected and interviewed. Data were collected through pretesting, semi-structural questionnaires, and field observation. The overall frequency of diseases reported as the main health constraint was Newcastle disease (64%) followed by gastrointestinal infection (34%), respiratory syndrome (22%), internal and external parasites (16%), coccidiosis (15%), and fowl pox (5%). They had no awareness how to manage chicken diseases (91.5%), and their flocks were not vaccinated (84%). High disease occurrence is reported in long rainy season (59%). Ethno-vet practice was experienced by the majority of the interviewed households (51.9%). A total of 19 medicinal plants were reported as being used as a traditional medicine. The main causes of losses were identified as disease (67%) and predator attack (32%). Poor disease prevention and control and the lack of knowledge and management skills were the major constraints of poultry production in the study areas. Research and extension efforts should be directed at the identified constraints. Farmer training and improvement of veterinary services are important.",signatures:"Meskerem Adamu Chere",downloadPdfUrl:"/chapter/pdf-download/64559",previewPdfUrl:"/chapter/pdf-preview/64559",authors:[{id:"265422",title:"Dr.",name:"Meskerem",surname:"Adamu",slug:"meskerem-adamu",fullName:"Meskerem Adamu"}],corrections:null},{id:"65450",title:"Veterinarian’s Role in Conservation Medicine and Animal Welfare",doi:"10.5772/intechopen.84173",slug:"veterinarian-s-role-in-conservation-medicine-and-animal-welfare",totalDownloads:1392,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"The enhanced role of human actions brings new escalating conservation challenges and emerging diseases, which pressure impaired long-term survival of threatened free-ranging and captive wildlife species, while having hazardous effects on ecosystems and public health. Veterinarians have not only a broad education in comparative medicine (not a single-species focus) but also are also highly trained in recognizing, diagnosing and understanding disease impact on public health as well as on individuals, populations and whole ecosystems. Their skills and expertise turns them into valuable key players in planning, implementing and effectively assisting both in-situ and ex-situ conservation projects. In parks and zoological gardens, major goals have now won priority: the conservation of worldwide fauna and flora and the protection of animal welfare. Today, animal welfare can be scientifically assessed to determine the quality of life of individuals, in which behavioral assessment and behavioral enrichment are fundamental tools.",signatures:"Diana Raquel Neves Fernandes and Maria de Lurdes Ribeiro Pinto",downloadPdfUrl:"/chapter/pdf-download/65450",previewPdfUrl:"/chapter/pdf-preview/65450",authors:[{id:"161692",title:"Prof.",name:"Maria De Lurdes",surname:"Pinto",slug:"maria-de-lurdes-pinto",fullName:"Maria De Lurdes Pinto"},{id:"279598",title:"Dr.",name:"Diana",surname:"Fernandes",slug:"diana-fernandes",fullName:"Diana Fernandes"}],corrections:null},{id:"65535",title:"Reptilian Skin and Its Special Histological Structures",doi:"10.5772/intechopen.84212",slug:"reptilian-skin-and-its-special-histological-structures",totalDownloads:2968,totalCrossrefCites:4,totalDimensionsCites:8,hasAltmetrics:1,abstract:"Reptilian skin is covered with scales forming armor that makes it watertight and enables reptiles to live on land in contrast to amphibians. An important part of the skin is the horny epidermis, with thick stratum corneum in which waxes are arranged in membrane-like layers. In lizards and snakes, the whole skin is covered in overlapping epidermal scales and in turtles and crocodiles in dermal scutes. The cornified part of the epidermis is strengthened by β-keratin and sometimes α-keratin. In crocodiles and many turtles, the outer scale surface consists of β-keratin and the hinge region containing α-keratin. In lizards and snakes, both keratins form continuous layers with the α-keratin below the β-keratin. Some reptiles have developed a sensitive mechanosensory system in the skin. The colors of reptile skin are produced by melanocytes and three types of chromatophores: melanophores, xanthophores, and iridophores. The color patterns may be fixed or the chromatophores may provide rapid color change. Skin from different species of reptiles, turtles (red-eared slider (Trachemys scripta elegans)), snakes (Emerald tree boa (Corallus caninus) and Burmese python (Python bivittatus)), Cuvier’s dwarf caiman (Paleosuchus palpebrosus), lizards (Leopard Gecko (Eublepharis macularius)), and Green iguana (Iguana iguana), were examined with histology techniques and compared.",signatures:"Catrin Sian Rutland, Pia Cigler and Valentina Kubale",downloadPdfUrl:"/chapter/pdf-download/65535",previewPdfUrl:"/chapter/pdf-preview/65535",authors:[{id:"246149",title:"Dr.",name:"Valentina",surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:{id:"19",series:{id:"13",title:"Veterinary Medicine and Science",issn:"2632-0517",editor:{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}}}},tags:[{id:"23",label:"women in science book program"}]},relatedBooks:[{type:"book",id:"9081",title:"Equine Science",subtitle:null,isOpenForSubmission:!1,hash:"ac415ef2f5450fa80fdb9cf6cf32cd2d",slug:"equine-science",bookSignature:"Catrin Rutland and Albert Rizvanov",coverURL:"https://cdn.intechopen.com/books/images_new/9081.jpg",editedByType:"Edited by",editors:[{id:"202192",title:"Dr.",name:"Catrin",surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10497",title:"Canine Genetics, Health and Medicine",subtitle:null,isOpenForSubmission:!1,hash:"b91512e31ce34032e560362e6cbccc1c",slug:"canine-genetics-health-and-medicine",bookSignature:"Catrin Rutland",coverURL:"https://cdn.intechopen.com/books/images_new/10497.jpg",editedByType:"Edited by",editors:[{id:"202192",title:"Dr.",name:"Catrin",surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Such neural networks could be applied in various applications such as image recognition, facial recognition, speech recognition, language translation, audio generation, and time-series prediction. This book reviews the past development, new perspectives, and application of such neural networks. It could provide a great understanding of the current state of neural networks and work out the frameworks for developing neural networks in the future.
",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"e57ff97a39cfc6fe68a1ac62b503dbe9",bookSignature:"Dr. Chi Leung Patrick Hui",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11448.jpg",keywords:"Supervised Learning, Unsupervised Learning, Reinforcement Learning, Neural Networks, ANN, CNN, RNN, LSTM, Image Recognition, Text Recognition, Language Translation, Voice Generation",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 6th 2022",dateEndSecondStepPublish:"June 3rd 2022",dateEndThirdStepPublish:"August 2nd 2022",dateEndFourthStepPublish:"October 21st 2022",dateEndFifthStepPublish:"December 20th 2022",remainingDaysToSecondStep:"9 days",secondStepPassed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"A pioneering researcher in artificial intelligence, machine learning, and deep learning, and holder of four registered patents: ‘’Thermosensitive poloxamer hydrogel for atopic dermatitis treatment”, “Development Method of Making Double Layers maturation of human monocyte-derived dendritic cells,” “Intelligent Monitoring System and Method on Diaper,” and “RFID Passive Tags Anti-counterfeiting System” of Chinese Herbal Medicine onto Cotton Fabric. 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He is a Chartered Engineer and is a chartered member of both the British Computer Society and the Chartered Institute of Marketing. He has published over 50 refereed journal papers such as Textile Research Journal, Computers in Industry, IEEE Transactions on Engineering Management, Expert Systems with Application and IEEE Transactions on Systems, Man and Cybernetics – Parts A and C and refereed conference papers. 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A fundamental strategy associated with supply chains is that of a ‘Responsive Chain’. A responsive chain focuses on its ability to respond quickly to demand changes and meet them within the shortest possible time. A responsive chain, by its very definition, has
Thus, we are led naturally to the use of system-dynamic methods and concepts of control theory for effective control of a supply chain. In the following sections we explore the dynamic modeling and analysis concepts in effectively controlling a supply chain that would yield good performance characteristics.
Supply chain dynamics essentially deals with the dynamic behavior and temporal variation of the inventories and flows in the system over time when subjected to demand disturbances.
We now look at a simple three stage serial supply chain, a schematic diagram of which is given below in Figure 1. Each stage represents an inventory storage facility in the chain. Stage 1 represents the raw material input storage to a manufacturing plant, and stage 2 the finished goods inventory storage at the manufacturing plant. Stage 3 represents the finished goods warehouse (W/H) at the downstream end of the chain which meets the demand for the finished product, and from which material is shipped out to customers. The inventory levels at each stage are the state variables of the system, and the material flows between the stages the control variables.
A three-stage serial supply chain.
In constructing a dynamic model of a supply chain system, we adopt the standard schematic diagram (Figure 1), system notation, and model variables and equations below, as commonly found in control theory literature [1, 2, 3, 4, 5, 6, 7, 8, 9].
We use a discrete time representation of the SC system, as this is more in keeping with the prevailing practices in the SC industry, wherein the inventory levels (state variables) are recorded at the end of each period or day. In most cases the state variable records are updated at the end of each day. Hence, we take our period to be a single day. However, we need to also emphasize that this need not always be so and would be dependent entirely on the convenience of the SC practitioners. And hence the state variables are recorded at epochs corresponding to the end of each period. The flow variables however are aggregated and taken to occur within and up to the end of each period.
The inventory and flow variables are subscripted to indicate the stages in the chain. We now give the detailed representation below:
with: i = 1, representing (the raw material) the upstream end of the production facility.
i = 2 representing (the finished goods) the downstream end of the production facility.
i = 3 representing (the finished goods) the warehouse.
The dynamic equations of the system are written using deviation variables, as under:
where,
Under consistent units (in equivalent units of finished goods) for all inventory and flows in the system, the dynamic equations of the system are written as:
where for i = 3,
Now, since the demand is a stochastic variable, it can be split into two components, viz., a mean demand component, and a stochastic component which represents the random variations over and above the mean demand. The mean demand is what is predicted using forecasting techniques and is the planned offtake and the demand that the system is designed to meet in the normal course. Since prediction can never be exact, the residual variation is the stochastic component.
In such stochastic systems, the demand has an additional stochastic term, which is a white noise term, given by
The standard initial conditions for the system are:
The demand disturbance could be of the following Types:
a sudden shock demand increase, represented by a Dirac delta input function.
a sudden and sustained increase in demand, represented by a step input.
a demand with an increasing trend, represented by a ramp input function.
a demand with second order (quadratic), third order (cubic), or higher-order trends represented by higher-order polynomial input functions.
a demand with seasonality, represented by a sinusoidal input function.
A random component which is represented by a White Noise process.
The first five components pertain to and define
The demand can have any combination of, or even all of the above components in the mean demand, and, of course, the additional stochastic component represented by a White Noise process. Such demands are often seen in supply chain warehouses.
Thus, a demand disturbance at the downstream end (at the warehouse) provides the perturbation to the system. The system is controlled through regulation/control of the replenishment flows which are the control variables in the system.
Now from the above, we can see that the system response will have two components, the
The performance metrics of a supply chain that would be of interest to us from a dynamic performance point of view and control system design are explained below.
Since the demand input to the system suddenly increases, we can expect the system response to lag the demand and to fluctuate, as the system scrambles to catch up with the increased demand. Accordingly, the key performance indicators that would be of importance and interest to us from the point of view of both design and operation are the following [1, 2, 3, 4, 5, 6, 7, 8, 9]:
Permanent depletion of the inventory level (the offset), if any.
The trough value or the lowest dip in the inventory levels (the undershoot).
The amplitude of fluctuations of the inventory.
The center-line about which fluctuations occur.
The fraction of time the inventory level stays depleted (in the negative region).
The limiting inventory variance.
The first indicator shows whether the system is able to catch up with the demand and whether it is ultimately restored to its original level, or not. The second indicator, the trough value, represents the lowest point or value that the inventory level is likely to touch, and impacts the
The two most common triggers for initiation of replenishment control action in the system are [1, 2, 3, 4, 5, 6, 7, 8, 9]:
The inventory levels at the W/H, as found in logistic systems and warehouses,
The demand variations at the W/H, as in electronic-data-interchange systems.
Thus, the control flows into the W/H are set to a function of the latest available inventory deviations and latest available Demand deviations. Thus, we have,
We discuss these points in more detail for a single stage system first.
To differentiate between the standard abbreviations in conventional control theory, we adopt the following notation used to indicate the type of control used.
P, PI, PID would represent Proportional, Proportional-integral, and Proportional-integral-derivative control as usual. Additionally, MA denotes a ‘Moving Average’ type of control (explained in detail subsequently).
An ‘I’ within parenthesis would represent ‘inventory-triggered’ control, while ‘D’ within parenthesis would denote a ‘Demand-triggered’ control. Also, ‘ID’ within parenthesis would denote a control which would have both inventory-triggered and Demand-triggered components. We give examples below.
Thus P(D) (pronounced as “P of D”) denotes Demand-triggered Proportional control, PI(I) denotes Inventory-triggered PI control. Similarly, PID(ID) (pronounced as “PID of ID”) denotes PID control with inventory-triggered and Demand-triggered components.
We also could have cases of multiple inventory triggers and multiple-demand triggers. These will be denoted as follows:
We now first look at a single stage system below which we take to be the warehouse end of a SC.
Since the demand has both a deterministic component as well as a stochastic component, the response of the system can also be broken down into two components, viz., a deterministic part which is
From the above discussion we can see the close parallel with conventional feedback control theory. Here the information about the warehouse inventory (the state variable) is fed back to the system for initiating replenishment flow control action. Additionally, we can also have controls wherein the disturbance is also directly fed back to the system for initiation of control action.
In close parallel with classical feedback control theory, the control flows are functions of the state variables and the demand or input perturbation to the system. The types of functions used also closely parallel classical control theory. And hence we have P, PI, and PID controls.
Additionally, we also have Moving Average (MA) controls, wherein the control flow is set to a weighted Moving Average of the latest available inventory deviations of up to ‘r’ periods back. The parameter ‘r’ is termed the ‘Order’ of the Moving Average.
We first look at Proportional Controls.
Now, for Proportional Controls of the P(I) type, the control flows into the warehouse in stage 3 of the chain would be given by:
where
The development herein corresponds to the ‘Regulator Problem’ with ‘set point’ of zero. And hence control of a Responsive Chain parallels the regulator problem in conventional control theory.
In conventional modeling of SCs, the lag is taken as the number of periods strictly between the period of order initiation and the period of arrival of the consignment, not including the period of arrival of the consignment. Thus, the lag is taken to be zero if the replenishment consignment arrives in the period immediately succeeding the period of order initiation. Instantaneous replenishment is not envisaged and is very rare in SC contexts. Arrival of the consignment within the same period of order initiation is also not envisaged and is very rare in such contexts. The earliest arrival of an ordered consignment is taken to be the immediately succeeding period, for which we take the lag as zero.
This convention is based on what is normally followed in the industry and practice, as well as the literature on dynamic modeling of SCs.
Hence in our further development of dynamic models of SCs we take the lag as zero if an order initiated in period k i.e., in the interval (k – 1, k] arrives in period (k + 1), i.e., in the interval (k, k + 1].
For a transportation lag of ‘l’ periods, an order placed in the interval (k – 1, k] would arrive in the interval (k + l, k + l + 1].
Hence for the warehouse under
Now it is to be noted that the order is initiated in period k i.e., in the interval (k – 1, k] based on the
Thus, warehouse records would be updated at the closure of the day’s operations and would show the
This is the convention that we will follow in the further development of the models.
We next look at the next type of control, which is the PI(I) control.
For the Proportional-Integral (PI(I) type) control case with
where the second term is the integral term in our discrete-time system, and Kc is the proportionality constant (gain term) factor of the integral of the error.
Next we have the PID(I) control wherein the control flows into the warehouse under
where the last term represents the derivative term in our discrete-time system, and Kd is the proportionality constant factor (gain term) of the derivative component of the control.
Next we have the Moving Average (MA) type of control (MA(I) type), for which the control flows into the warehouse under
where the r is the order of the moving average, the Ks are the control parameters (the weights) of the MA terms. Thus, the control flow is set to a weighted moving average of the latest available fully observed inventory levels up to r period back.
The above controls discussed above are the conventional inventory-triggered schemes. In all these types of controls, we could additionally have demand-triggered terms also, like the PI(ID), PID(ID), MA(ID) etc.
We discuss some of them below for single stage systems.
Firstly, we note herein that in solving for the response of a supply chain system, we will not use the Z-transform nor block diagrams and transfer functions as in conventional control theory. Rather we will work directly on the system difference equation in the time domain itself. And instead, we will use direct Operator methods to obtain the system solution and response (rather than the transformed equations and inverse transforms). This is one of the advantages of this modeling paradigm.
Another advantage of the type of discrete time modeling taken up here is that
We now take up the simplest form of control which is the P(I) control and illustrate the formulation of the system equation and its solution method.
The control is an inventory-triggered Proportional control. And we take the Replenishment Lag = 0 in the simplest case.
The flow balance equation for the warehouse is given by:
The control flows into the warehouse are given by:
It is to be noted that the value of
Thus, we can clearly see that the controls are of the ‘feedback’ type, and they seek to keep the inventory deviation at zero level, which is just the’ Linear Regulator with zero set-point’ in standard control theory.
Thus, substituting for the control flow into the flow balance eqn. Above, yields the system-dynamic eqn. For the warehouse as:
The above is the deterministic part of the system equation. Since demand is a stochastic variable with a stochastic component, the complete system equation is given by:
which has both parts. To solve the system equation completely, we split it into its two components and solve for each of the components separately. We hence solve the following two equations, one each for the deterministic part and the stochastic part.
The first is a deterministic Linear Difference Equation, and the second, a Stochastic Linear Difference Equation (SDE).
Both are second-order Linear Difference Equations (LDEs) in the state variable
An excellent treatment of difference calculus and solution methods for LDEs is given in [10]. We follow the methods given therein.
In order to solve the LDE, we first introduce the Forward Shift Operator E as under:
Now using the forward Shift Operator E, we can write the LDE in Operator form as:
We first look at the deterministic part of the solution below, which will yield the
Now this is an LDE of order two (the order being the highest power of the Operator E).
We write the Characteristic Equation of the LDE as [10]:
to determine the characteristic roots of the LHS Operator.
The stability of the system is entirely controlled by the roots of the LHS Operator. And elementary analysis leads to the following stability conditions:
Now we take up the solution of the system LDE for a unit step increase in demand, i.e.,
Substituting for the demand disturbance in the system equation yields the LDE:
which we can call the “Original Non-Homogeneous Eqn.” (O-NHE).
We first look at the solution of the homogeneous LDE (i.e., with RHS = 0). The homogeneous LDE is:
which upon factoring the LHS Operator can be written as: (
which has the solution as:
For a repeated root, the solution is given by:
Now that we have the solution of the homogeneous LDE, we next look for a particular solution of the Original Non-Homogeneous LDE (O-NHE).
A standard method of solution of the Non-homogeneous eqn. is by the ‘Annihilator Method’ [10].
We look for the Operator that annihilates the RHS terms of the O-NHE, say A(E). Then operating by the Annihilator on both sides of the O-NHE yields:
which is a homogeneous LDE albeit of a higher order, but which can be solved by factorizing the LHS Operator. As an example, in our case of a unit step disturbance,
And the Annihilator is given by:
And hence the equivalent Homogeneous LDE is given by:
which has the solution:
Now we note that the O-NHE being of order two, will admit only two undetermined constants. The above solution, however, has three undetermined constants. The third was introduced by us due to the Annihilator. Hence to determine the extra constant D in the solution, we substitute the solution into the O-NHE to determine D. Thus, and noting that the terms involving the roots of the LHS operator of the O-NHE are precisely the homogeneous solution terms of the O-NHE, we only need substitute the extra terms introduced by the Annihilator into the O-NHE. Hence, we have:
Noting that E(D) = D itself (
Thus, the full solution is given by:
Now, for stable solutions, we will have
The Damping rate, which is the rate at which the fluctuations decay to zero are given by the magnitudes of the roots of the LHS Operator
We take the case of distinct roots first, say for a value of
Hence, we have the system equation as:
The roots of the LHS Operator are readily obtained as:
which shows a Damping Rate of the Order of
P(I) control.
We next take a value of
which shows a Damping Rate of the Order of
Thus, while we would like the oscillations to be damped out rapidly, this would compromise on the Offset value, which would impact the base stock requirements of the system.
Thus, for the practitioner, the implications are quite clear:
We next obtain the undetermined constants in the general solutions above, using the Initial Conditions (ICs) of the system, as under:
The standard ICs of the system are as:
Now the system LDE:
And hence the ICs for our warehouse system can be obtained from the system equation itself using the standard system ICs and yields:
We additionally examine the case for
which can be simplified to.
where H(.) is the unit Heaviside step function and yields a sinusoidal pattern with a center-line of – 1 and constant amplitude of
This last case is that of
The responses for the three cases above are plotted in Figure 2.
We next look at the determination of the limiting inventory variance, which is a measure of the variation that we could expect even after the system (mean inventory level) has been restored to its original value.
Also, for the behavior of the mean response as well as our inferences from it to be meaningful, it is necessary that the limiting inventory variance be bounded and finite. We can then expect the inventory levels to be within the band given by:
In order to determine the limiting inventory variance, we make use of the stochastic component of the system equation and determine the stochastic part of the response. For our system the Stochastic LDE (or SDE) is as under:
where the term on the RHS of the SDE is the random variation represented by a White Noise Process, with
We can note that the LHS Operator is again the same as in the deterministic part of the system LDE that we have solved for above. Hence the roots of the LHS Operator remain unaltered in the SDE also.
Now following the method used in [11], we can note that if
where the
And hence the stochastic part of the solution of the system eqn. can be written as an infinite linear combination of the white noise disturbance terms.
Now since the individual white noise terms are Uncorrelated and Normal, i.e., with
In order to solve for the weighting terms, the βs, we substitute the solution into the system SDE above, as under:
which is
Another and more convenient way to write the SDE is to use the Backward Shift Operator
The SDE for the βs becomes:
which is
Now comparing coefficients of ε(k) for each k, yields the system of equations as below:
LDE term | Coefft of ε(k) | Coefft of ε(k-1) | Coefft of ε(k-2) | Coefft of ε(k-3) | Coefft of ε(k-4) | Coefft of ε(k-5) | …. | Coefft of ε(k) |
---|---|---|---|---|---|---|---|---|
1 | ….. | |||||||
- | 0 | ….. | ||||||
0 | 0 | ….. | ||||||
RHS | -1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The above set of equations yields:
We can note that the LHS Operator is the same as for the system LDE, and hence has the same characteristics and form of solution.
We first illustrate the computation for the stable case
To obtain the limiting inventory variance, we firstly note that:
And hence,
Hence, we have:
We next illustrate the computation for the marginally stable case
And we can see from the above that the βs oscillate in value, from −1 to 0 to +1 infinitely often, i.e., the sequence {…0, −1, −1, 0, +1,+1, 0…..} repeats infinitely often. And hence the series
Hence in this case the limiting inventory variance is
It can similarly be shown that the limiting inventory variance is not bounded for unstable solutions also.
Thus, the limiting inventory variance will be bounded only for stable cases.
We can also note from the above discussion and work up that we have also obtained the stochastic part of the solution, as:
where
The above representation proves useful for simulation purposes.
We next take up the P(ID) control. We discuss only the deterministic system LDE hereafter, since the stochastic part of the solution and the limiting inventory can be obtained by methods similar to that discussed above in all cases to follow.
In this type of control an additional demand-triggered component is also added to the control thereby making it more proactive. The control initiates corrective replenishment action no sooner than a demand deviation is observed. It does not wait for an inventory deviation to take place before initiating replenishment action though it does have an inventory-triggered component also.
The replenishment control flow is given by:
where the first term is the inventory-triggered component and the second the demand-triggered component. Substituting for the control flow into the system equation yields:
which can be written as
We can note that the addition of the demand-triggered component has left the LHS of the LDE unaltered. Thus, the LHS Operator of the LDE remains the same and is unaffected by addition of demand-triggered components to the control. The system eqn. can hence be written in Operator form as:
Since
The ICs for the LDE have been obtained from the system Eq. (55) above using the standard system ICs;
Since the LHS Operator is the same as for the earlier P(I) control, the stability analysis remains the same as earlier, as also the roots of the LHS Operator for various values of the inventory-trigger parameter discussed earlier, i.e.,
The solutions are the same as given earlier in Eqs. (25) and (26).
And substituting the solution back into the O-NHE yields the value of the extra constant D as
which hence yields the solutions for the two cases as:
where the offset term is now given by
The important point to note in the above solution is that the offset can be made zero by choice of the demand-trigger parameter as
And hence we can observe the enhanced response of the P(ID) control over the earlier P(I) control, in that the Offset can now be controlled by us by choice of
In fact, we can also achieve a (+)ve value of the offset by choosing
We can now obtain the full solutions for the three cases above, using the LDE ICs
The solution curves are plotted in Figure 3, from which we can see that the response in all cases has zero offset.
P(ID) control.
We can similarly extend the modeling and analysis to PI(I), PID(I), and MA(ID) controls.
We could also have different types of input disturbances as indicated earlier in Section 3.1. Additionally, the third dimension of our analysis could be to have non-zero lags, i.e., lags of one, two periods, and so on. Cases with non-zero and higher lags will result in higher order system LDEs, and the LHS Operator would be of a higher order.
Further details of the above can be obtained in [1, 2, 3, 4, 5, 6, 7, 8, 9].
We look at the serial supply chain system as given in Figure 1.
We can see from Figure 1 that the immediately succeeding downstream stage in a supply chain will provide the “demand perturbation” for the immediately preceding stage. Thus, the demand perturbation at the warehouse at the downstream end will successively be felt up the chain. And the single-stage analysis described above can be used in turn for each stage of the chain.
For non-serial supply chains, the arguments are similar and single-stage analysis can be used as described above.
Details of some of these analyses can be found in [1, 2, 3, 4, 5, 6, 7, 8, 9].
This chapter has presented the application of control concepts to the control of supply chains. The state variables have been taken to be the inventory levels, while the control variables are the replenishment flows into the various stages of the system. The conventional P, PI, PID controls have been discussed, as also some newer forms of control which are especially applicable to supply chains and warehouses. The performance of P(I) and P(ID) controls have been derived in detail, and their performance analyzed.
A significant feature of this chapter is that the conventional block diagrams and transfer functions of conventional control theory have not been used. Rather direct Operator Methods have been used to good advantage to solve the system equations.
The gallstones (Figure 1) are hard, pebble-like pieces of material, usually made of cholesterol or bilirubin, that develop in the gallbladder [1]. These stones are formed due to various disorders. Five defects primarily play critical role in pathogenesis of cholesterol stones Viz lithogenes and genetic factors; hepatic hypersecretion of cholesterol; rapid phase transition of cholesterol in bile; impaired gallbladder motility; intestinal factors involving absorption of cholesterol, slow intestinal motility and altered gut microbiota.
Cholesterol gallstones and gallbladder after cholecystectomy.
Gallstones affect about 15% of United States population. About 10–20% of the United States population will get gallstones at some point in their life time and females are more affected than men [2].
Gallstones can cause biliary colic, cholecystitis, pancreatitis, empyema Gallbladder, perforation of gallbladder, cholangitis, bile duct obstruction [3], and cancers (gallbladder [4], colorectal [5, 6], pancreatic [7]). In 85% of patients with gallbladder cancer, gall stones are present [8]. Gallbladder cancer is a very fatal cancer with average survival of 6 months [9] and 5-year survival rate of 5% [8]. This bad prognosis is because of silent features. An increased mortality from cardiovascular disease and cancer was found to be associated with gallstones by an 18 year national study [10]. Asymptomatic cholelithiasis are present in 80% of cases and most of these are incidentally found when the patients are under investigation for other ailments [11]. In general, 10–25% of asymptomatic cases may develop symptoms during the patient’s lifetime [12]. The estimated cost for gallbladder diseases was 6.5 billion dollar annually in United States only in 2002 [13].
There are three types of gallstones; first and most common type is cholesterol stone. Black and brown pigmented stones are the other two types of gallstones. The prevalence of various types of gallstones in the western world is: 75% of gallstones are cholesterol stones, 20% are black pigment stones, and 5% or less are brown pigment stones. Cholesterol and black pigment stones are formed exclusively in gallbladder in a sterile medium, while as brown pigment stones are formed everywhere in the biliary tree owing to the anaerobic bacterial infection. Stasis of bile is an essential component in the formation of gallstone or bile duct stone formation [14]. In underdeveloped countries parasitic infection of biliary tree is associated with brown pigment stones [15].
Physical-chemical origin is the basis of pathogenesis of sterile stones (cholesterol and black pigment stones) [16]. There is an alteration in lipid and lipo-pigment composition which results in the formation of stones. In cholesterol and black pigment stones the major component is cholesterol monohydrate crystals and calcium hydrogen bilirubinate respectively. During the long stay in gallbladder, the black pigment gets degraded and polymerized by free radicals and helps in the formation of black pigment stones while as in the brown pigment stones the main mechanism is infectious where the enzymatic hydrolysis of biliary lipids by anaerobic bacterial enzymes produces supersaturated long chain fatty and deconjugated bile acids [14, 17].
Gallstone formation occurs as a result of interaction between genetic and environmental factors in which few are unmodifiable and unaltered as age and genetic makeup. The traditional risk factors for gallstones are four “F” female, fertile, fat, forty and some have added fifth “F” for fair skin [18].
Various intrinsic and extrinsic risk factors for the causation of different types of gallstones are genetic factors, advanced age, female gender, parity, ethnicity, rapid weight loss, different medications (oestrogen replacement therapy, oral contraceptive pills), total parenteral nutrition [19], obesity, westernized diet, Type 2 diabetes mellitus, metabolic syndrome [20], dyslipidaemia, hyperinsulinemia [21], increased enterohepatic circulation of bilirubin [22], defective gall bladder motility [23] as shown in Table 1.
Risk factors for gallstone diseases | |
---|---|
Intrinsic factor | Extrinsic factor |
Age | Lipid profile |
Gender | Diet |
Ethnicity | Obesity |
Defective gallbladder motility | Weight loss |
Physical activity | |
Genetics | Diseases |
Medication |
Risk factors for gallbladder stone diseases.
Age is an important factor for the stone formation, with increase in age enzyme 7 α hydroxylase (Limiting enzyme for bile acid synthesis) activity decreases which increases the saturation of cholesterol in bile and hence increasing the chances of stone formation [24].
Various genes are linked with increased susceptibility of gallstones like Lith genes identified in mouse models [25]. Two variants of ATP binding Cassette transporters ABCG5-R50C and ABCG8-D19H [26]; 3 variants of Farnesoid X Receptor gene (FXR) (rs 35724, rs 11110358, rs 11110386) [27]; polymorphism of apolipoprotein E4 allele [28]; mucin genes [29]; fibroblast growth factor receptor 4 (FGFR4) [30], polymorphism in CCK 1-R gene [31] are linked with cholelithiasis. The genetic factors are responsible for 25–30% of symptomatic gallstones as inferred from twin studies [32]. Gene expressions are affected by environmental factors and gene-environmental interactions through epigenetic mechanisms [33] also involving fat storage and insulin resistance [34]. These factors primarily include micro RNAs [35] Viz. 114 miRNA [36], miR-122 [37].
Females are having a higher risk factors due to various reasons for cholelithiasis such as higher oestrogen levels naturally [38], multiparity [39] and ingestion of oral contraceptives containing oestrogens [38]. Females also tend to undergo cholecystectomy procedure more than males [40].
Ethnicity plays an important non-modifiable role in cholelithiasis as few ethnic groups are having higher incidence of having gall stones as in North American Indians (73% among women more than 30 years old within Prima Tribe) [14], American Indians (men 29.5%, women 64.1%) [41]. Prevalence of Gallstone and Gallbladder Cancer are co-related and effects certain indigenous population like South America & North India, especially younger population [42].
Risk of deaths from gallbladder cancer and other malignancies has been observed to be seven times more in tribal members with gallstones [43].
The co-relation between lipids and cholesterol stone formation is complex, multi factorial and is dependent on other factors also as few studies are in favour and few showing inverse relationship [14]. Few studies show high LDL [44], high cholesterol [45], low HDL [46] are associated with higher gall stone formation which seems to be evident but other studies show there are having inverse relationship with gallstone formation like low HDL, high cholesterol and high LDL [14].
Cholesterol gallstones are associated with western diet [47]. Multiple studies have shown high carbohydrate intake couples with high glycemic load [48], chronic hypernutrition [49] fibre depleted diet [50] are associated with higher risk for cholelithiasis in process which are associated with decreased risk are intake of in saturated fat [51], coffee [52], fibre [53], fish oil [54], calcium [55], ascorbic acid [56], fresh fruits and vegetables [57] and nuts [51].
Obesity is itself risk factor for cholelithiasis. It has been shown that an obese women (BMI ≥ 30 kg/m2) has two fold and morbidly obese women (BMI ≥ 45 kg/m2) has seven fold higher risk for cholelithiasis as compared to lean women (BMI < 25 kg/m2) [58].
Rapid weight loss i.e., >1.5 kg/week and or loss of body weight >25% [59] are risk factors for cholelithiasis which usually occur after bariatric surgery. Weight loss has also been found to reduce risk of gallstones except when rapid loss occurs.
Physical activity decreases risk for cholelithiasis [60] as it improves hepatobiliary funtions, gut motility [61], increasing HDL [62], improves insulin release and plasma triglyceride levels [63]. An endurance exercise (cycling and running) 5 times per week for 30 minutes daily decreases risk by 34% for cholelithiasis [64] or 2–3 h/week of recreational exercise decrease risk by 20% for cholecystectomy [60]. While as reduced physical activity increases risk for cholelithiasis [64].
Various diseases increase the risk for cholelithiasis as these work by different mechanisms like causing abnormal gallbladder motility, malabsorption of bile salts, decreased bile salt synthesis [65], increasing bile cholesterol saturation [66], supersaturation of bile and increased hepatic cholesterol secretion [67]. Different diseases increasing risk for cholelithiasis viz. metabolic syndrome, dyslipidaemia, diabetes (2–3 fold [68]), insulin resistance or hyperinsulinemia [69], chronic hepatitis C virus [66], liver cirrhosis (25–30% increased risk [65] and Chron’s disease [70].
Both these habits have controversial results from various studies some favouring and others refuting association with cholelithiasis.
Men consuming alcohol 0–20 g per day have higher risk than those who consume 20–60 g per day [24]. But few studies show severe alcohol abuse in itself and also led to chronic cirrhosis (pigment stones), which is an independent risk factor for cholelithiasis [71].
Cigarette smoking is another risk factor for gallstones among woman [72], while as few studies refute these claims show no association with gallstones [73].
An imbalance between absorption and synthesis of cholesterol i.e., increased biliary cholesterol secretion from high dietary cholesterol and decreased bile acid synthesis and pool, all driving bile supersaturation [22]. High cholesterol diet and high intestinal cholesterol absorption are two independent risk factors for gallstones [74], regulated by many factors like expression of sterol transport protein [75].
In patients with cholelithiasis there is evidence of altered gut microbiota with increment of intestinal bacterial phylum proteobacteria decrement of
Defective gallbladder motility is another risk factor for cholesterol stones [78]. About one-third of patients with cholesterol gallstones display enlarged fasting and post prandial residual gallbladder volume with delayed emptying which antedates gallstone formation [79]. Sufficient time for cholesterol nucleation and gallstone growth is provided by dysfunctional gallbladder motility [80]. Various conditions are associated with dysfunctional gallbladder motility like insulin resistance, diabetes, irritable bowel syndrome, liver cirrhosis, and so on [81]. There is increase in lithogenic bile secretion to small intestine directly from liver in fasting motility defect, leading to faster recycling of bile acids and increasing bile acid pool hydrophobicity [82]. This is another predisposing factor for cholesterol crystallization and cholelithiasis [83].
Various defects occur simultaneously for the nucleation and crystallization of cholesterol monohydrate viz unphysiological supersaturation with cholesterol, accelerated nucleation and gallbladder hypomotility [16]. The mucin glycoprotein hypersecretion follows and lead to the stone formation [84].
Excessive secretion of cholesterol into bile leads to cholesterol supersaturation [85] owing to multiple biochemical defects either from increased input (de novo synthesis, lipoprotein uptake) or decreased disposition (de novo bile salt and cholesteryl ester synthesis) [84]. However single defects in hepatocellular processing of cholesterol are known viz
Increased number of apolipoprotein B/E and E receptors (constitutional/oestrogens/rapid weight loss/diet)
Increased activity of hydroxy-methyl-glutaryl-CoA reductase (obesity/hypertriglyceridemia/fibric acids)
Diminished activity of cholesterol 7α-hydroxylase (constitutional/fibric acids)
Diminished activity of Acyl CoA: cholesterol acyltransferase (constitutional/progestogens) [86]
These changes resulting in the increased levels of cholesterol in microsomes [87] and cytosol [88] of hepatocytes in patients with gallstones. Sterol carrier protein 2 concentration also increases simultaneously [89].
At puberty hypersecretion of cholesterol into bile begins [90]. In liver excess cholesterol is delivered to bile by a relay station [91]. Postprandially the cholesterol is completely micellized by bile salts and lecithin during healthy condition [92]. Cholesterol molecules are absorbed by gallbladder mucosa efficiently from micelles of supersaturated bile [93] where the activity of acyl coenzyme A: cholesterol acyl transferase esterifies the sterol [87]. But the molecules that remain free are dissolved in plasma and intercellular membranes where they become intercalated with and stiffen the phospholipid molecules [86]. Reverse diffusion when gallbladder bile become unsaturated or esterification is the only means of escape of membrane cholesterol as gallbladder mucosa does not produce cholesterol [92].
The abnormity in diurnal variation of gallbladder bile due to hypersecretion of cholesterol lead to the further trapping of excess free cholesterol molecules into gallbladder mucosa and muscle membranes [94]. There occurs the divergence of hepatic bile into gastrointestinal tract due to impaired motor and mucosal functions of gallbladder [95]. This in turn lead to increased bacterial catabolism and turnover of primary bile salts [92], which ultimately increase the production of secondary bile salts (hydrophobic bile salts) and suppress de novo bile salt synthesis [96].
Rapid recirculation and hydrophobicity are harmful for the stability of bile as these lead to the augmentation of secretion of cholesterol and hydrophobic lecithin molecules, which in turn shorten the time of nucleation of supersaturated bile [91]. The hydrophobicity of bile salt pool also increases secretion of total proteins into bile [97] and also altering the ratio of pro and anti-nucleating activities for cholesterol crystallization [97]. Multiple stimuli trigger mucin glycoprotein hypersecretion like cholesterol in itself [87], ‘cytotoxic’ filamentous cholesterol crystals [98], prostanoids [99], and hydrophobic bile salts e. g Deoxycholate and lithocholate conjugates [100]. This lead to the development of mucin gel on gallbladder wall and then as a crescent in gallbladder lumen, setting stage for accelerated nucleation. This together with hypomotility lead to its accumulation as biliary sludge, failure of complete evacuation of which lead to gallstone formation [84]. However, the end result may become inevitable by an environmental perturbation that inauspiciously tips the delicate pathophysiological and physical-chemical balance of supersaturated bile towards nucleation and stone growth [86].
Black stones occur in sterile environment [101] with increased frequency in patients of chronic haemolysis. A shift in ratio of bilirubin diconjugates to the favour of monoconjugates especially monoglucuronides occur due to hypersecretion of bilirubin conjugates in bile [102]. Bile pigment output increases by 10-fold with haemolysis [102] and predominantly becomes monoconjugates that are more hydrolysed by endogenous β glucuronidase [101]. This gives rise to very high levels of unconjugated pigment exceeding biliary solubility [101]. The insoluble acid calcium salt [Ca (HUCB)2] forms at pH values typical of gallbladder bile [103]. Unphysiological supersaturation occurs with an elevation in the ion product of calcium and monoacid species of unconjugated bilirubin [101] facilitating factors like in cholesterol stones are important for stone formation. The prevalence of pigment stones increases with age and is gender dependent; and all haemolytic patients does not develop pigment stones [101]. In experimental studies it was shown that there is no gallbladder motility defect in black pigment stone formation [104]. However, mucin hypersecretion occurs [105] in response to the high levels of unconjugated bilirubin [106] or mucosal cell cytotoxicity of earliest precipitates [107]. Nucleation is initiated at glandular crypts of gallbladder mucosa where mucin gel accumulates first [107]. Biliary supersaturation (owing to defective acidification of hepatic bile [101] with organic salts occur which is indicated by presence of crystalline calcium carbonate and phosphates in black pigment stones [101]. 3–20% of black pigment stones are composed of mucin glycoprotein [108]. Various factors came into play and through different mechanisms give rise to pigment stone formation in alcoholic cirrhosis, ileal dysfunction and in aging Viz bile salt hyposecretion, defective solubilization of unconjugated bilirubin, impaired calcium ion binding, haemolysis, defective bilirubin conjugation [101], enteric hyperbilirubinobilia [86].
Chronic anaerobic infection with functional stasis of bile ducts is necessary for brown pigment stones. Stasis in bile duct occur due to secondary stones from gallbladder, or due to sphincter of Oddi dysfunction or parasitic infections (mostly underdeveloped countries) [84]. Commencing with stasis of bile and then followed by anaerobic bacterial infection lead to accumulation of both mucin gel and bacterial cytoskeleton in bile ducts. Bacterial enzymes (phospholipase A, β glucuronidase) hydrolyse the biliary lipids that contain amide or ester linkages which results in the nucleation of cholesterol monohydrate crystals A trap is laid down in the form of culture medium for anaerobic bacteria by mucin gel and solid components making their exit difficult. This is a vicious cycle formed between growing stone, stasis of bile and bacterial infection [84, 109].
IntechOpen aims to ensure that original material is published while at the same time giving significant freedom to our Authors. To that end we maintain a flexible Copyright Policy guaranteeing that there is no transfer of copyright to the publisher and Authors retain exclusive copyright to their Work.
',metaTitle:"Publication Agreement - Chapters",metaDescription:"IN TECH aims to guarantee that original material is published while at the same time giving significant freedom to our authors. For that matter, we uphold a flexible copyright policy meaning that there is no transfer of copyright to the publisher and authors retain exclusive copyright to their work.\n\nWhen submitting a manuscript the Corresponding Author is required to accept the terms and conditions set forth in our Publication Agreement as follows:",metaKeywords:null,canonicalURL:"/page/publication-agreement-chapters",contentRaw:'[{"type":"htmlEditorComponent","content":"The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Book Chapter:
\\n\\n1. DEFINITIONS
\\n\\nCorresponding Author: The Author of the Chapter who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author.
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\\n\\nIntechOpen: IntechOpen Ltd., the Publisher of the Book.
\\n\\nBook: The publication as a collection of chapters compiled by IntechOpen including the Chapter. Chapter: The original literary work created by Corresponding Author and any Co-Author that is the subject of this Agreement.
\\n\\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\\n\\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\\n\\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\\n\\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Chapter but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Chapter as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\\n\\nThe Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\\n\\nSubject to the license granted above, copyright in the Chapter and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\\n\\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Chapter.
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\\n\\n3. CORRESPONDING AUTHOR'S DUTIES
\\n\\n3.1 When distributing or re-publishing the Chapter, the Corresponding Author agrees to credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Chapter.
\\n\\n3.2 When submitting the Chapter, the Corresponding Author agrees to:
\\n\\nThe Corresponding Author will be held responsible for the payment of the Open Access Publishing Fees.
\\n\\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\\n\\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Chapter worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\\n\\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\\n\\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\\n\\n4. CORRESPONDING AUTHOR'S WARRANTY
\\n\\n4.1 The Corresponding Author represents and warrants that the Chapter does not and will not breach any applicable law or the rights of any third party and, specifically, that the Chapter contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Chapter is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Chapter has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\\n\\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Chapter to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Chapter was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Chapter on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\\n\\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\\n\\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\n5. TERMINATION
\\n\\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co-Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\\n\\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\\n\\n6. INTECHOPEN’S DUTIES AND RIGHTS
\\n\\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Chapter attributing it to the Corresponding Author and any Co-Author.
\\n\\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Chapter and has the right to contact the Corresponding Author and any Co-Author until the Chapter is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Chapter, IntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\n7. MISCELLANEOUS
\\n\\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\\n\\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\\n\\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\\n\\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\\n\\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\\n\\nLast updated: 2020-11-27
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The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Book Chapter:
\n\n1. DEFINITIONS
\n\nCorresponding Author: The Author of the Chapter who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author.
\n\nCo-Author: All other Authors of the Chapter besides the Corresponding Author.
\n\nIntechOpen: IntechOpen Ltd., the Publisher of the Book.
\n\nBook: The publication as a collection of chapters compiled by IntechOpen including the Chapter. Chapter: The original literary work created by Corresponding Author and any Co-Author that is the subject of this Agreement.
\n\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\n\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\n\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Chapter but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Chapter as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\n\nThe Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Chapter and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\n\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Chapter.
\n\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\n\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co-Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Chapter as a consequence of IntechOpen's changes to the Chapter arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\n\n3. CORRESPONDING AUTHOR'S DUTIES
\n\n3.1 When distributing or re-publishing the Chapter, the Corresponding Author agrees to credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Chapter.
\n\n3.2 When submitting the Chapter, the Corresponding Author agrees to:
\n\nThe Corresponding Author will be held responsible for the payment of the Open Access Publishing Fees.
\n\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\n\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Chapter worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\n\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\n\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\n4. CORRESPONDING AUTHOR'S WARRANTY
\n\n4.1 The Corresponding Author represents and warrants that the Chapter does not and will not breach any applicable law or the rights of any third party and, specifically, that the Chapter contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Chapter is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Chapter has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Chapter to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Chapter was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Chapter on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\n\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\n\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\n5. TERMINATION
\n\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co-Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\n\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\n\n6. INTECHOPEN’S DUTIES AND RIGHTS
\n\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Chapter attributing it to the Corresponding Author and any Co-Author.
\n\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Chapter and has the right to contact the Corresponding Author and any Co-Author until the Chapter is publicly available on any platform owned and/or operated by IntechOpen.
\n\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Chapter, IntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\n7. MISCELLANEOUS
\n\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\n\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\n\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\n\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\n\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\n\nLast updated: 2020-11-27
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Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"682",title:"Aerodynamics",slug:"aerospace-engineering-aerodynamics",parent:{id:"111",title:"Aerospace Engineering",slug:"aerospace-engineering"},numberOfBooks:6,numberOfSeries:0,numberOfAuthorsAndEditors:118,numberOfWosCitations:49,numberOfCrossrefCitations:70,numberOfDimensionsCitations:112,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"682",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10775",title:"Hypersonic Vehicles",subtitle:"Applications, Recent Advances, and Perspectives",isOpenForSubmission:!1,hash:"0eb40c595ae6a0a77f2bd4102c00a2e6",slug:"hypersonic-vehicles-applications-recent-advances-and-perspectives",bookSignature:"Giuseppe Pezzella and Antonio Viviani",coverURL:"https://cdn.intechopen.com/books/images_new/10775.jpg",editedByType:"Edited 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Habitats",slug:"unmanned-aerial-systems-uass-for-environmental-monitoring-a-review-with-applications-in-coastal-habi",totalDownloads:2416,totalCrossrefCites:14,totalDimensionsCites:22,abstract:"Nowadays the proliferation of small unmanned aerial systems or vehicles (UAS/Vs), formerly known as drones, coupled with an increasing interest in tools for environmental monitoring, have led to an exponential use of these unmanned aerial platforms for many applications in the most diverse fields of science. In particular, ecologists require data collected at appropriate spatial and temporal resolutions to describe ecological processes. For these reasons, we are witnessing the proliferation of UAV-based remote sensing techniques because they provide new perspectives on ecological phenomena that would otherwise be difficult to study. Therefore, we propose a brief review regarding the emerging applications of low-cost aerial platforms in the field of environmental sciences such as assessment of vegetation dynamics and forests biodiversity, wildlife research and management, map changes in freshwater marshes, river habitat mapping, and conservation and monitoring programs. In addition, we describe two applications of habitat mapping from UAS-based imagery, along the Central Mediterranean coasts, as study cases: (1) The upper limit of a Posidonia oceanica meadow was mapped to detect impacted areas, (2) high-resolution orthomosaic was used for supporting underwater visual census data in order to visualize juvenile fish densities and microhabitat use in four shallow coastal nurseries.",book:{id:"5847",slug:"aerial-robots-aerodynamics-control-and-applications",title:"Aerial Robots",fullTitle:"Aerial Robots - Aerodynamics, Control and Applications"},signatures:"Daniele Ventura, Andrea Bonifazi, Maria Flavia Gravina and Gian\nDomenico Ardizzone",authors:[{id:"198366",title:"Ph.D.",name:"Daniele",middleName:null,surname:"Ventura",slug:"daniele-ventura",fullName:"Daniele Ventura"},{id:"205321",title:"Mr.",name:"Andrea",middleName:null,surname:"Bonifazi",slug:"andrea-bonifazi",fullName:"Andrea Bonifazi"},{id:"205335",title:"Dr.",name:"Maria Flavia",middleName:null,surname:"Gravina",slug:"maria-flavia-gravina",fullName:"Maria Flavia Gravina"},{id:"205336",title:"Prof.",name:"Giandomenico",middleName:null,surname:"Ardizzone",slug:"giandomenico-ardizzone",fullName:"Giandomenico Ardizzone"}]},{id:"54685",doi:"10.5772/67915",title:"Underwater Optical Wireless Communication Systems: A Concise Review",slug:"underwater-optical-wireless-communication-systems-a-concise-review",totalDownloads:2305,totalCrossrefCites:16,totalDimensionsCites:16,abstract:"Underwater optical wireless communications (UOWC) have gained a considerable interest during the last years as an alternative means for broadband inexpensive submarine communications. UOWC present numerous similarities compared to free space optical (FSO) communications or laser satellite links mainly due to the fact that they employ optical wavelengths to transfer secure information between dedicated point‐to‐point links. By using suitable wavelengths, high data rates can be attained. Some recent works showed that broadband links can be achieved over moderate ranges. Transmissions of several Mbps have been realized in laboratory experiments by employing a simulated aquatic medium with scattering characteristics similar to oceanic waters. It was also demonstrated that UOWC networks are feasible to operate at high data rates for medium distances up to a hundred meters. However, it is not currently available as an industrial product and mainly test‐bed measurements in water test tanks have been reported so far. Therefore, extensive research is expected in the near future, which is necessary in order to further reveal the “hidden” abilities of optical spectrum to transfer broadband signals at higher distances. The present work summarizes the recent advances in channel modeling and system analysis and design in the area of UOWC.",book:{id:"5801",slug:"turbulence-modelling-approaches-current-state-development-prospects-applications",title:"Turbulence Modelling Approaches",fullTitle:"Turbulence Modelling Approaches - Current State, Development Prospects, Applications"},signatures:"Lydia K. Gkoura, George D. Roumelas, Hector E. Nistazakis, Harilaos\nG. Sandalidis, Alexander Vavoulas, Andreas D. Tsigopoulos and\nGeorge S. Tombras",authors:[{id:"19522",title:"Prof.",name:"George S.",middleName:null,surname:"Tombras",slug:"george-s.-tombras",fullName:"George S. Tombras"},{id:"23386",title:"Prof.",name:"Hector",middleName:"E.",surname:"Nistazakis",slug:"hector-nistazakis",fullName:"Hector Nistazakis"},{id:"171669",title:"Ms.",name:"Lydia",middleName:null,surname:"Gkoura",slug:"lydia-gkoura",fullName:"Lydia Gkoura"},{id:"171670",title:"Prof.",name:"Andreas",middleName:null,surname:"Tsigopoulos",slug:"andreas-tsigopoulos",fullName:"Andreas Tsigopoulos"},{id:"171672",title:"Dr.",name:"Alexander",middleName:null,surname:"Vavoulas",slug:"alexander-vavoulas",fullName:"Alexander Vavoulas"},{id:"199221",title:"MSc.",name:"George D.",middleName:null,surname:"Roumelas",slug:"george-d.-roumelas",fullName:"George D. Roumelas"},{id:"199222",title:"Prof.",name:"H.G.",middleName:null,surname:"Sandalidis",slug:"h.g.-sandalidis",fullName:"H.G. Sandalidis"}]},{id:"66116",doi:"10.5772/intechopen.84982",title:"High Entropy Alloys for Aerospace Applications",slug:"high-entropy-alloys-for-aerospace-applications",totalDownloads:1605,totalCrossrefCites:8,totalDimensionsCites:13,abstract:"In the aerospace industry, materials used as modern engine components must be able to withstand extreme operating temperatures, creep, fatigue crack growth and translational movements of parts at high speed. Therefore, the parts produced must be lightweight and have good elevated-temperature strength, fatigue, resistant to chemical degradation, wear and oxidation resistance. High entropy alloys (HEAs) characterize the cutting edge of high-performance materials. These alloys are materials with complex compositions of multiple elements and striking characteristics in contrast to conventional alloys; their high configuration entropy mixing is more stable at elevated temperatures. This attribute allows suitable alloying elements to increase the properties of the materials based on four core effects , which gives tremendous possibilities as potential structural materials in jet engine applications. Researchers fabricate most of these materials using formative manufacturing technologies; arc melting. However, the challenges of heating the elements together have the tendency to form hypoeutectic that separates itself from the rest of the elements and defects reported are introduced during the casting process. Nevertheless, Laser Engineering Net Shaping (LENS™) and Selective Laser Melting (SLM); a powder-based laser additive manufacturing process offers versatility, accuracy in geometry and fabrication of three-dimensional dense structures layer by layer avoiding production errors.",book:{id:"8558",slug:"aerodynamics",title:"Aerodynamics",fullTitle:"Aerodynamics"},signatures:"Modupeola Dada, Patricia Popoola, Samson Adeosun and Ntombi Mathe",authors:[{id:"169258",title:"Dr.",name:"Patricia",middleName:null,surname:"Popoola",slug:"patricia-popoola",fullName:"Patricia Popoola"},{id:"285697",title:"M.Sc.",name:"Modupeola",middleName:null,surname:"Dada",slug:"modupeola-dada",fullName:"Modupeola Dada"},{id:"292368",title:"Dr.",name:"Samson",middleName:null,surname:"Adeosun",slug:"samson-adeosun",fullName:"Samson Adeosun"},{id:"292369",title:"Dr.",name:"Ntombi",middleName:null,surname:"Mathe",slug:"ntombi-mathe",fullName:"Ntombi Mathe"}]},{id:"55155",doi:"10.5772/67918",title:"Numerical Analysis of Laminar‐Turbulent Bifurcation Scenarios in Kelvin‐Helmholtz and Rayleigh‐Taylor Instabilities for Compressible Flow",slug:"numerical-analysis-of-laminar-turbulent-bifurcation-scenarios-in-kelvin-helmholtz-and-rayleigh-taylo",totalDownloads:1704,totalCrossrefCites:5,totalDimensionsCites:8,abstract:"In the chapter, we are focused on laminar-turbulent transition in compressible flows triggered by Kelvin-Helmholtz (KH) and Rayleigh-Taylor (RT) instabilities. Compressible flow equations in conservation form are considered. We bring forth the characteristic feature of supersonic flow from the dynamical system point of view. Namely, we show analytically and confirm numerically that the phase space is separated into independent subspaces by the systems of stationary shock waves. Floquet theory analysis is applied to the linearized problem using matrix-free implicitly restarted Arnoldi method. All numerical methods are designed for CPU and multiGPU architecture using MPI across GPUs. Some benchmark data and features of development are presented. We show that KH for symmetric 2D perturbations undergoes cycle bifurcation scenarios with many chaotic cycle threads, each thread being a Feigenbaum-Sharkovskiy-Magnitskii (FShM) cascade. With the break of the symmetry, a 3D instability develops rapidly, and the bifurcations includes Landau-Hopf scenario with computationally stable 4D torus. For each torus, there exist threads of cycles that can develop chaotic regimes, so the flow is more complicated and difficult to study. Thus, we present laminar-turbulent development of compressible RT and KH instabilities as the bifurcations scenarios.",book:{id:"5801",slug:"turbulence-modelling-approaches-current-state-development-prospects-applications",title:"Turbulence Modelling Approaches",fullTitle:"Turbulence Modelling Approaches - Current State, Development Prospects, Applications"},signatures:"Nikolay Mihaylovitch Evstigneev and Nikolai Alexandrovitch\nMagnitskii",authors:[{id:"96107",title:"Prof.",name:"Nikolai A.",middleName:"Alexandrovich",surname:"Magnitskii",slug:"nikolai-a.-magnitskii",fullName:"Nikolai A. Magnitskii"},{id:"151627",title:"Dr.",name:"N. M.",middleName:null,surname:"Evstigneev",slug:"n.-m.-evstigneev",fullName:"N. M. Evstigneev"}]},{id:"55909",doi:"10.5772/intechopen.69396",title:"Computational Aeroelasticity of Flying Robots with Flexible Wings",slug:"computational-aeroelasticity-of-flying-robots-with-flexible-wings",totalDownloads:1947,totalCrossrefCites:2,totalDimensionsCites:6,abstract:"A computational co‐simulation framework for flying robots with flexible wings is presented. The authors combine a nonlinear aerodynamic model based on an extended version of the unsteady vortex‐lattice method with a nonlinear structural model based on a segregated formulation of Lagrange’s equations obtained with the Floating Frame of Reference formalism. The structural model construction allows for hybrid combinations of different models typically used with multibody systems such as models based on rigid‐body dynamics, assumed‐modes techniques, and finite‐element methods. The aerodynamic model includes a simulation of leading‐edge separation for large angles of attack. The governing differential‐algebraic equations are solved simultaneously and interactively to obtain the structural response and the flow in the time domain. The integration is based on the fourth‐order predictor‐corrector method of Hamming with a procedure to stabilize the iteration. The findings are found to capture known nonlinear behavior of flapping-wing systems. The developed framework should be relevant for conducting aeroelastic studies on a wide variety of air vehicle systems.",book:{id:"5847",slug:"aerial-robots-aerodynamics-control-and-applications",title:"Aerial Robots",fullTitle:"Aerial Robots - Aerodynamics, Control and Applications"},signatures:"Sergio Preidikman, Bruno Antonio Roccia, Marcos Leonardo\nVerstraete, Marcelo Federico Valdez, Dean T. Mook and Balakumar\nBalachandran",authors:[{id:"201035",title:"Dr.",name:"Sergio",middleName:null,surname:"Preidikman",slug:"sergio-preidikman",fullName:"Sergio Preidikman"},{id:"201037",title:"Dr.",name:"Bruno A.",middleName:null,surname:"Roccia",slug:"bruno-a.-roccia",fullName:"Bruno A. Roccia"},{id:"201038",title:"Dr.",name:"Marcos L.",middleName:null,surname:"Verstraete",slug:"marcos-l.-verstraete",fullName:"Marcos L. Verstraete"},{id:"201039",title:"Dr.",name:"Marcelo F.",middleName:null,surname:"Valdéz",slug:"marcelo-f.-valdez",fullName:"Marcelo F. Valdéz"},{id:"201040",title:"Dr.",name:"Balakumar",middleName:null,surname:"Balachandran",slug:"balakumar-balachandran",fullName:"Balakumar Balachandran"},{id:"201041",title:"Dr.",name:"Dean T.",middleName:null,surname:"Mook",slug:"dean-t.-mook",fullName:"Dean T. Mook"}]}],mostDownloadedChaptersLast30Days:[{id:"69603",title:"Introduction to Satellite Attitude Control",slug:"introduction-to-satellite-attitude-control",totalDownloads:1332,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter will introduce the space environment satellites must operate in, the motion they make in orbit, and their orientation while in orbit. The forces acting on the spacecraft will be considered, along with the implications of conservation of energy. The fundamentals of orbital mechanics will be presented, so common orbits can be visualized and discussed in terms of the six classical orbital elements. Perturbations impacting the orbit are covered for a better understanding of how orbits change over time. The inertial frame of reference will be defined and then transformed into body coordinates of the satellite using the direction cosine matrix and quaternions to describe the attitude of the spacecraft. A variety of modern attitude control techniques will be developed in the following chapters.",book:{id:"7761",slug:"advances-in-spacecraft-attitude-control",title:"Advances in Spacecraft Attitude Control",fullTitle:"Advances in Spacecraft Attitude Control"},signatures:"Henry Travis",authors:[{id:"290765",title:"Mr.",name:"Henry",middleName:null,surname:"Travis",slug:"henry-travis",fullName:"Henry Travis"}]},{id:"56312",title:"Design and Development of Aerial Robotic Systems for Sampling Operations in Industrial Environment",slug:"design-and-development-of-aerial-robotic-systems-for-sampling-operations-in-industrial-environment",totalDownloads:1453,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter describes the development of an autonomous fluid sampling system for outdoor facilities, and the localization solution to be used. The automated sampling system will be based on collaborative robotics, with a team of a UAV and a UGV platform travelling through a plant to collect water samples. The architecture of the system is described, as well as the hardware present in the UAV and the different software frameworks used. A visual simultaneous localization and mapping (SLAM) technique is proposed to deal with the localization problem, based on authors’ previous works, including several innovations: a new method to initialize the scale using unreliable global positioning system (GPS) measurements, integration of attitude and heading reference system (AHRS) measurements into the recursive state estimation, and a new technique to track features during the delayed feature initialization process. These procedures greatly enhance the robustness and usability of the SLAM technique as they remove the requirement of assisted scale initialization, and they reduce the computational effort to initialize features. To conclude, results from experiments performed with simulated data and real data captured with a prototype UAV are presented and discussed.",book:{id:"5847",slug:"aerial-robots-aerodynamics-control-and-applications",title:"Aerial Robots",fullTitle:"Aerial Robots - Aerodynamics, Control and Applications"},signatures:"Rodrigo Munguia, Edmundo Guerra, Sarquis Urzua, Yolanda Bolea\nand Antoni Grau",authors:[{id:"13038",title:"Prof.",name:"Antoni",middleName:null,surname:"Grau",slug:"antoni-grau",fullName:"Antoni Grau"},{id:"18024",title:"Dr.",name:"Yolanda",middleName:null,surname:"Bolea",slug:"yolanda-bolea",fullName:"Yolanda Bolea"},{id:"163432",title:"Dr.",name:"Rodrigo",middleName:null,surname:"Munguia",slug:"rodrigo-munguia",fullName:"Rodrigo Munguia"},{id:"165970",title:"Ph.D. Student",name:"Edmundo",middleName:null,surname:"Guerra",slug:"edmundo-guerra",fullName:"Edmundo Guerra"},{id:"201103",title:"Mr.",name:"Sarquis",middleName:null,surname:"Urzua",slug:"sarquis-urzua",fullName:"Sarquis Urzua"}]},{id:"55140",title:"Interface Instability and Turbulent Mixing",slug:"interface-instability-and-turbulent-mixing",totalDownloads:1677,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Richtmyer‐Meshkov instability and turbulent mixing are fundamental problems of multi‐materials interface dynamics, which mainly focuses on the growth of perturbation on the interface and mixing of different materials. It is very important in many applications such as inertial confinement fusion, high‐speed combustion, supernova, etc. In this chapter, we will gain advances in understanding this problem by numerical investigations, including the numerical method and program we used, the verification and validation of numerical method and program, the growth laws and mechanics of turbulent mixing, the effects of initial conditions, the dynamic behavior, and some new phenomenon for Richtmyer‐Meshkov instability and turbulent mixing.",book:{id:"5801",slug:"turbulence-modelling-approaches-current-state-development-prospects-applications",title:"Turbulence Modelling Approaches",fullTitle:"Turbulence Modelling Approaches - Current State, Development Prospects, Applications"},signatures:"Jingsong Bai and Tao Wang",authors:[{id:"199258",title:"Mr.",name:"Tao",middleName:null,surname:"Wang",slug:"tao-wang",fullName:"Tao Wang"},{id:"199259",title:"Prof.",name:"Jingsong",middleName:null,surname:"Bai",slug:"jingsong-bai",fullName:"Jingsong Bai"}]},{id:"66116",title:"High Entropy Alloys for Aerospace Applications",slug:"high-entropy-alloys-for-aerospace-applications",totalDownloads:1598,totalCrossrefCites:8,totalDimensionsCites:13,abstract:"In the aerospace industry, materials used as modern engine components must be able to withstand extreme operating temperatures, creep, fatigue crack growth and translational movements of parts at high speed. Therefore, the parts produced must be lightweight and have good elevated-temperature strength, fatigue, resistant to chemical degradation, wear and oxidation resistance. High entropy alloys (HEAs) characterize the cutting edge of high-performance materials. These alloys are materials with complex compositions of multiple elements and striking characteristics in contrast to conventional alloys; their high configuration entropy mixing is more stable at elevated temperatures. This attribute allows suitable alloying elements to increase the properties of the materials based on four core effects , which gives tremendous possibilities as potential structural materials in jet engine applications. Researchers fabricate most of these materials using formative manufacturing technologies; arc melting. However, the challenges of heating the elements together have the tendency to form hypoeutectic that separates itself from the rest of the elements and defects reported are introduced during the casting process. Nevertheless, Laser Engineering Net Shaping (LENS™) and Selective Laser Melting (SLM); a powder-based laser additive manufacturing process offers versatility, accuracy in geometry and fabrication of three-dimensional dense structures layer by layer avoiding production errors.",book:{id:"8558",slug:"aerodynamics",title:"Aerodynamics",fullTitle:"Aerodynamics"},signatures:"Modupeola Dada, Patricia Popoola, Samson Adeosun and Ntombi Mathe",authors:[{id:"169258",title:"Dr.",name:"Patricia",middleName:null,surname:"Popoola",slug:"patricia-popoola",fullName:"Patricia Popoola"},{id:"285697",title:"M.Sc.",name:"Modupeola",middleName:null,surname:"Dada",slug:"modupeola-dada",fullName:"Modupeola Dada"},{id:"292368",title:"Dr.",name:"Samson",middleName:null,surname:"Adeosun",slug:"samson-adeosun",fullName:"Samson Adeosun"},{id:"292369",title:"Dr.",name:"Ntombi",middleName:null,surname:"Mathe",slug:"ntombi-mathe",fullName:"Ntombi Mathe"}]},{id:"55173",title:"Statistical Modeling for the Energy-Containing Structure of Turbulent Flows",slug:"statistical-modeling-for-the-energy-containing-structure-of-turbulent-flows",totalDownloads:1359,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The development of statistical theory for the energy-containing structure of turbulent flows, taking the phenomenon of internal intermittency into account, is proposed, and new differential equations for conditional means of turbulent and nonturbulent fluid flow are established. Based on this fact, a new principle of constructing mathematical models is formulated as the method of autonomous statistical modeling of turbulent flows, ASMTurb method. Testing of the method is attained on the example of constructing a mathematical model for the conditional means of turbulent fluid flow in a turbulent mixing layer of co-current streams. Test results showed excellent agreements between the predictions of the ASMTurb model and known experimental data.",book:{id:"5801",slug:"turbulence-modelling-approaches-current-state-development-prospects-applications",title:"Turbulence Modelling Approaches",fullTitle:"Turbulence Modelling Approaches - Current State, Development Prospects, Applications"},signatures:"Yuriy Nuzhnov",authors:[{id:"198896",title:"Dr.",name:"Yuriy",middleName:null,surname:"Nuzhnov",slug:"yuriy-nuzhnov",fullName:"Yuriy Nuzhnov"}]}],onlineFirstChaptersFilter:{topicId:"682",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. 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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"79909",title:"Cryopreservation Methods and Frontiers in the Art of Freezing Life in Animal Models",doi:"10.5772/intechopen.101750",signatures:"Feda S. 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He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"5",type:"subseries",title:"Parasitic Infectious Diseases",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11401,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"ofsBook.detail",path:"/welcome/e57ff97a39cfc6fe68a1ac62b503dbe9",hash:"",query:{},params:{hash:"e57ff97a39cfc6fe68a1ac62b503dbe9"},fullPath:"/welcome/e57ff97a39cfc6fe68a1ac62b503dbe9",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()