Open access peer-reviewed Edited Volume

Human Blood Group Systems

Osaro Erhabor

Usmanu Danfodiyo University Teaching Hospital

Covering

Disease Predisposition Haemolytic Disease Newborn Organs Transplantation Blood Group Serology Immune Recognition Haemolytic Reactions Universal Donor Adequacy of Blood

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About the book

One of the greatest challenges of blood transfusion worldwide is accessibility to safe and adequate supplies of blood and blood products. Blood group systems are associated with antigens expressed on the red cell membrane, human tissues and organs. Their specificity is often determined by a single gene locus or by two or more very closely linked homologous genes located on the chromosome. The aim of red cell transfusion and solid organ transplant is to ensure the optimum survival of the introduced donor allograft. Apart from the ABO and Rhesus blood group system, the International Society of Blood Transfusion has recognized another 33 blood group systems. Blood grouping and cross-matching is one of the ways to ensure the survival of donors red cells in the recipient. A full understanding of the human blood group systems, their clinical significance, their link to diseases, blood typing, alloantibody investigation and cross-matching is critical in order to prevent transfusion reactions and organ rejection. To facilitate access to safe and adequate supply of blood and blood products globally, there is need to critically look at a number of options aimed at genetic and antigenic modulation of human red cells to prevent the immune system from recognizing and mounting an immune response that often result in haemolytic transfusion reaction and alloimmunization. Such strategies include; the enzymatic conversion of specific blood group antigens such as the enzyme converted group O-RBC (ECO-RBC) concept, the potential masking of red cell antigens by treating human red cells with polyethylene glycol (the stealth RBC concept) and the in vitro mass production of red cells in culture media using genetically manipulated and modified stem cells for the production of blood that can potentially be used as universal donor units. The aim of this book is to look at the diversity and clinical relevance of the human blood group systems and identify ways to ensure the safe, adequate supply and optimum survival of allografts (red cells and organs) in recipients.

Publishing process

Book initiated and editor appointed

Date completed: August 30th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 19th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 7th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 7th 2020

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About the editor

Osaro Erhabor

Usmanu Danfodiyo University Teaching Hospital

Professor Erhabor Osaro is a Chartered Scientist (CSci), Fellow of the Institute of Biomedical Science (FIBMS) of London and the Medical Laboratory Science Council of Nigeria (FMLSCN). He holds a doctor of philosophy degree in Immunohaematology from the Rivers State University of Science and Technology (RSUST) in Port Harcourt, Rivers State Nigeria. He completed the University of Greenwich (UK) Specialist Courses in Blood Transfusion and Laboratory Quality Management System. He also holds the British Blood Transfusion Society (BBTS) Specialist Certificate in Blood Transfusion Science Practice. He is an Alumni of Francis Turtle College of Technology in Oklahoma U.S.A. His teaching experience spans both Nigeria and the United Kingdom. His work experience includes working as a Specialist Biomedical Scientist at the RBH-a continuous quality improvement conscious and a centre of excellence in the implementation of lean principles in the health sector in Europe. He is an active member of several professional and scientific societies; British Blood Transfusion Society (BBTS), the International Federation of Biomedical Laboratory Science (IFBLS), African Society of Laboratory Medicine (ASLM), Institute of Biomedical Science UK (IBMS), European Haematology Association (EHA), Medical Laboratory Science Council of Nigeria (MLSCN) and the International Society of Laboratory Haematology (ISLH). He is the recipient of several awards, including the famous British Blood Transfusion Society Young Scientist Award and the Margaret Kenwright Young Scientist Award. He is a Registration and Specialist Portfolio Verifier/Examiner for the Institute of Biomedical Science of London. He is a member of the editorial board as well as an article reviewer for several local and international peer-reviewed scientific journals. A well-published contributor in the fields of Infectious Diseases, Immunohaematology and Transfusion Medicine. He is the author of 5 scientific books and several chapters.

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Book chapters authored 4

Books edited 1

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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