Open access peer-reviewed Edited Volume

Protein Kinase - New Opportunities, Challenges and Future Perspectives

Rajesh Singh

Punjab Technical University

A pioneering researcher of anticancer drug design, a beneficiary of Publon Award 2016, 2017 for the top reviewer. Publon Excellent Peer Reviewer Awardee, on reviewer's panel fo Royal Society Grants, appointed as PUBLON ACADEMY MENTOR and BENTHAM BRAND AMBASSADOR.


Protein Phosphorylation Cell Signalling Cancer Kinase Inhibitors FDA Therapeutic Implications Protein Kinase C Nervous System Circulatory System Digestive System Natural Products

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About the book

Protein kinase driven phosphorylation is one of the vital mechanisms controlling intracellular signalling pathways that regulate many cellular processes, such as cell division, proliferation, growth, survival and apoptosis. Alteration of different protein kinases can result in remarkable changes in these processes. Moreover, these protein kinases are frequently recognized as oncogenic and can be crucial for the survival and spread of cancer cells. Because of the fundamental role of protein kinases in cell biology and their function in numerous sarcomas and cancers, an intensive search for new kinase inhibitors in academia and industries has been enduring for the last two decades. Protein kinase has become the most imperative and commercial class of drug target which is attracting pharmaceutical industries to spend 30 % of their current research investments only in developing kinase inhibitors for various therapeutic implications. This is exemplified by the fact that 75 drugs targeting protein kinase have been clinically approved to date. More than 100 kinase inhibitors are in the final stages of development and likely to be approved in the coming years. There is plenty of scope to work in the area of exploring protein kinase as only about 10 % of kinases have been studied extensively to date. The development of kinase inhibitors is expected to be at the forefront of medicine for the foreseeable future.

In this context, this book intends to provide a collection of research and review articles from the experts focusing on protein kinases signalling pathways as a molecular drug target. Various chapters on the mechanism of action and antitumor activity of protein kinase inhibitors on various cancer types will also be presented. New opportunities, challenges and future perspectives in the context of the function of protein kinases will also be discussed in different chapters.

Publishing process

Book initiated and editor appointed

Date completed: January 18th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: April 16th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: July 5th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: September 3rd 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Rajesh Singh

Punjab Technical University

Dr. Rajesh Kumar Singh was born in 1980. He received his B. Pharmacy (2003) and M. Pharmacy (2005) from UIPS, Panjab University, Chandigar. He started to teach Pharmaceutical Chemistry at the Shivalik College of Pharmacy, Nangal, in 2006, where he completed his PhD in 2013 from the IKG Punjab Technical University (IKGPTU), Jalandhar. His major area of research interests are drug-design, polymer-drug conjugates for targeted delivery to cancerous cells and CNS, antimalarial therapeutic agents, natural product chemistry and green chemistry approaches for chemical synthesis. Dr. Singh has over 15 years of teaching experience and guided 01 PhD and 18 PG students. He is currently guiding 02 PhDs and 01 M. Pharmacy students. He has published more than 60 peer-reviewed SCI-indexed scientific research papers of total impact factor more than 100 in various Chemistry and Pharmacy Journals including the European Journal of Medicinal Chemistry, Biorganic Chemistry, Biomedicine and Pharmacotherapy, European Journal of Pharmaceutical Sciences, Mini-Reviews in Medicinal Chemistry, Pharmaceutical Research, Medicinal Chemistry, Bentham, J. Enzyme Inh. Med Chem. (Informa Healthcare), Res. Chem. Intermediate (Springer), Arabian Journal of Chemistry, etc as main or corresponding author. He currently serves on Editorial Advisory Board Member of 09 Peer-reviewed International Journals including SCI indexed MRMC and PeerJ. He has received Publon Award 2016, 2017 for top reviewer and 'Publon Excellent Peer Reviewer Award” for outstanding reviewing more than 150 research papers of different International Journals of ACS, RSC, Springer, Elsevier, Dove, Informa, and Bentham of Impact Factor varies from 1.0 to 9.5. He has also to his credit 46 National and International Conference Abstracts, 2 Book, 5 Best Paper Presentation Awards, 1 Travel grants to attend Int. Conf. and 5 Research Projects funded by Govt. Agencies, India. He is also on the panel of International Reviewer for reviewing Research Proposal for Royal Society Grants. He is also serving as PUBLON ACADEMY MENTOR and BENTHAM BRAND AMBASSADOR.

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