About the book
Drug repositioning is a promising field in drug discovery that identifies new therapeutic opportunities for existing drugs. It can provide new treatment options to overcome cancer cell resistance or drug resistance in general. In this regard, old drugs seem to be ideal candidates for either reposition or combination therapy with known chemotherapeutic drugs. Despite the continuous research for treating cancer patients for example , chemotherapy and surgery are considered the main treatment options for many cancer patients worldwide. However, development of cancer cell resistance to chemotherapy remains a major obstacle for successful treatment and decreases sensitivity to different current chemotherapeutic drugs . Development of cancer cell resistance is attributed to different cellular mechanisms such as development of multidrug resistance (MDR). Therefore, there is no wonder that several research studies have been directed toward discovery of chemosensitizing agents among commonly available approved drugs that will not only increase sensitivity of cancer cells but will also decrease the applied doses of chemotherapeutic drugs and their associated side effects. Therefore, several researches have been directed to discover novel compounds that interfere with these efflux pumps such as P-glycoprotein and consequently enhance cancer cell sensitivity towards chemotherapeutic drugs. Recently, it has been proved that an old anti-malarial drug chloroquine showed to be a good candidate for interfering with MDR in several types of cancer. Moreover, quinine, which is a known and commercially available natural anti-malarial alkaloid has been reported for its efficacy as chemosensitizer in human leukemic cells.
This book will be a self-contained collection of scholarly papers targeting an audience of practicing researchers, academics, PhD students and other scientists. The contents of the book will be written by multiple authors and edited by experts in the field.