About the book
Chronobiology is the science investigating and objectively quantifying the mechanisms of the biological time structure, including the rhythmic manifestations of life. The disturbance of the temporal structure of the living organism leads to disturbed harmony between biological rhythms the rhythm of external environment which often results in manifestations of various diseases. Circadian disruption may occur, and may be the result of phase shifts in the oscillation of the circadian and activity-controlled physiological processes, or can be induced by factors related to periodic inputs. For example, low contrast between day and night synchronizing signals; by Zeitgebers with different periods or unusual phasing or by Zeitgeber shifts (jet lag syndrome, shift work); factors related to oscillators (the uncoupling between the different oscillators inside the SCN, the uncoupling between the central and peripheral oscillators or clock gene functional alterations). Chronobiological disturbance can also be induced by factors related to outputs such as nocturnal melatonin suppression or loss of cortisol rhythm. Many pathological states can be promoted or impaired as consequences of circadian disruption. This planned book publication will include articles on recent research in the field of human chronobiology as well as experimental and clinical medicine.