About the book
Nuclear Magnetic Resonance (NMR) spectroscopy has emerged as one of the most powerful tools in chemistry and analytical science in general. NMR spectroscopy observes magnetic moments of atomic nuclei arising due to the intrinsic angular momentum called spin. These magnetic moments respond to magnetic fields, and in NMR experiments they are made to precess in a strong magnetic field. NMR experiments initiate the precession by using radio frequency pulse followed by the observation of precession of spins. The precession frequency is a characteristic of the atomic nucleus and hence NMR experiments reveal information about the atomic nature of the sample. The precession frequency is further modified by the chemical environment of the nucleus - the same nucleus can have slightly different frequency depending on its site in a molecule. This phenomenon is called chemical shift. Observing chemical shifts can reveal fingerprint information about the molecule. The nuclear spins in a molecule interact, which is a phenomenon called coupling, which can help to measure distances between the nuclei and aid in determining three-dimensional structures of molecules. Developments in molecular biology and NMR spectrosocpy have dramatically increased the use of NMR spectroscopy for obtaining structural and dynamical information of small to medium size biological macromolecules. The dipolar interaction between atomic nuclei in solutions gets averaged due to motional averaging, which does not happen in the solid state. Development of Magic Angle Spinning techniques have made it possible to average these interaction and obtain high resolution information of nuclear spin precession. Thus, the explosive growth of methods in solid state NMR spectrosocpy has been observed in the recent years.
This book aims to present some of the most exciting developments in the subject of NMR spectrosocpy.