Open access peer-reviewed Edited Volume

Heart Transplantation

Norihide Fukushima

National Cerebral and Cardiovascular Center

Dr. Norihide Fukushima did research concerning xenotransplantation, long-term cardiac preservation, and cardiac donation after cardiac death as well as clinical works. After returning to Japan in 1994, he has been mainly preparing heart transplantation systems and contributed first heart transplantation in Japan.


Immunosuppression Regimen New Immunosuppressant Rejection Diagnosis Pediatric Heart Transplantation Anti HLA Antibody Prevention Transplant Coronary Allograft Vasculopathy Posttransplant Lymphoproliferative Disorder Mechanical Circulatory Support ECMO mTOR Inhibitor

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About the book

Heart transplantation has been established as a definitive therapeutic strategy for patients with end-stage cardiac failure and its outcome was improved. However, long-term patient survival has been less improved due to many post-transplant complications. In this book, we would like to discuss topics concerning recent immunosuppression protocol and infection control after heart transplantation as well as complications after heart transplantation, such as antibody-mediated rejection, transplant coronary allograft vasculopathy, and posttransplant Lymphoproliferative disorder. Pediatric heart transplantation also increased up to 600/ year in the world. Pediatric heart transplantation has had special issues to be solved because a child is not a small adult. These issues, such as child growth and development, child care, special infection, immunosuppression will be discussed. Finally, patient death during waiting for heart transplantation has been also a big issue and mechanical circulatory support is one of the methods to solve this problem. The devices, such as ECMO, Impella, durable paracorporeal VAD, implantable VAD will be also discussed in terms of indication, strategies and outcome.

Publishing process

Book initiated and editor appointed

Date completed: September 9th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 7th 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: December 6th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 24th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 25th 2022

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About the editor

Norihide Fukushima

National Cerebral and Cardiovascular Center

Dr. Fukushima was born in Mexico City in August 1956. He graduated with an MD degree from the School of Medicine, Osaka University in 1982. Upon the residency in pediatric cardiac surgery at Osaka Children Hospital, he worked as an assistant cardiac surgeon and got his Ph.D. -Study of 24-hour immersed cardiac preservation by using terminal blood cardioplegia. Between November 1991 and March 1994, he was a researcher and Clinical Fellow at Loma Linda University, USA. He studied pediatric heart transplantation and researched xenotransplantation and cardiac donation after cardiac death. Dr. Fukushima returned to Japan in 1994 and became Professor at Osaka University. He participated in the preparation of the heart transplantation system in Japan and was part of the first heart transplantation in Japan. He also contributed to the revision of the Japanese Organ Transplant Act in 2010, which enabled brain dead organ donation in children and increased heart transplantation.

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