Open access peer-reviewed Edited Volume

Mutagenesis

Michael Fasullo

State University of New York Polytechnic Institute

Dr. Michael Fasullo is a well-known researcher in the field of DNA repair and recombination and has pioneered the use of budding yeast in studying the genetic toxicology of P450-activated carcinogens. He earned his B.S. at the Massachusetts Institute of Technology and his Ph.D. at Stanford University. After receiving postdoctoral training in radiation biology at Columbia University, he obtained his first faculty appointment at the Department of Therapeutic Radiation at Loyola University Medical School.

Covering

Error-Prone Polymerases Polymerase Switch Mechanisms Gene Amplification Transposons Spontaneous Deamination Uracil Alkylating Agents Transposons Double-Strand Break Repair Template Switch Mechanisms Triplet Repeat Amplification Microsatellite Instability

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About the book

Mutagenesis generates genetic variability for adaptation to changing environments. However, mutagenesis also drives genetic instability phenotypes that confer mitochondrial dysfunction, aging, and carcinogenesis. Organisms have therefore evolved mechanisms to balance accurate replication with mutagenesis. These mechanisms function at the level of DNA replication, post-replication repair, and replication fork stability. DNA polymerases must ensure timely replication while maintaining replication fidelity. Replication fork progression is challenged by DNA damage, which spontaneously occurs but is also inflicted by a multitude of mutagens. Error-prone polymerases and template switch mechanisms allow replication forks to bypass DNA damage. While replication errors can be partially corrected by mismatch repair, mismatch repair proteins, in turn, can drive triplet repeat amplification.

The purpose of this book will be to explore our current understanding of mutagenesis mechanisms. Topics discussed include current knowledge of error-prone polymerases, mismatch repair mechanisms, mutagens, and mutation signatures, spontaneous and induced mutagenesis, transposons, and drug resistance.

Publishing process

Book initiated and editor appointed

Date completed: August 24th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 20th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 8th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 9th 2022

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About the editor

Michael Fasullo

State University of New York Polytechnic Institute

The editor earned his B.S. at the Massachusetts Institute of Technology (1979) and his Ph.D. at Stanford University (1986). After receiving postdoctoral training in radiation biology at Columbia University, he obtained his first faculty appointment at the Department of Therapeutic Radiation at Loyola University Medical School. He later was tenured at The Albany Medical College and joined the faculty of the State University of New York Polytechnic Institute. He received research grants from the National Cancer Institute, the National Institute of Environmental and Health Sciences, Department of Defense, March of Dimes, and Leukemia Research Foundation. His research focus is on DNA recombinational repair and oncolytic viruses. His current research project focuses on profiling the yeast genome for resistance to aflatoxins and heterocyclic aromatic amines.

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Book chapters authored 2

Books edited 0

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