Flavonoid metal complexes commonly exhibit an improvement of biological activity compared to the parent ligands. This chapter is focused on the antioxidant and anticanc-cer properties of flavonoid metal complexes, in correlation with their binding ability to vital macromolecules such as nucleic acids and serum proteins. Perspectives for an adequate formulation of these complexes were also discussed.
Part of the book: Flavonoids
Cisplatin and analogs are used for the treatment of some type of cancers in combination with organic cytostatics. Also, two ruthenium (III) complexes are in clinical trials as anticancer drugs. In order to overcome toxicity and resistance associated with this therapy and/or enhance stability, a large variety of formulations based on organic, inorganic, or hybrid matrix were developed and tested both in vivo and in vitro. The best results were obtained for systems properly functionalized in order to enhance the metal content and/or to specific target the tumor tissue through overexpressed receptors.
Part of the book: Descriptive Inorganic Chemistry Researches of Metal Compounds