Cecilia Maldonado

University of the Republic Uruguay

Cecilia Maldonado is an assistant professor at the Pharmaceutical Sciences Department in the Faculty of Chemistry, UdelaR, Uruguay, and a researcher at the University Hospital in the Therapeutic Drug Monitoring Service. She completed her PhD degree in Efflux Transporter and Its Relationship to Anticonvulsant Therapeutics. In the recent years, she worked with the Pain Interdisciplinary Unit in the University Hospital on the follow-up of patients with chronic pain and also investigated methadone pharmacokinetics. She has published more than 20 papers in reputed journals and was awarded with the Grant for Professional Innovation from the International Pharmaceutical Federation (FIP) in 2013.

1books edited

3chapters authored

Latest work with IntechOpen by Cecilia Maldonado

Since the beginning of times, pain treatment has been the motive of research giving birth to multiple groups of pharmacological families and therapies. Pain perception is a construction built over the biological phenomenon of signal transduction surrounded by different factors such as gender, age, and sociocultural status, among others. The concept of pain as the solely biological manifestation of defense is nowadays considered as a narrow-minded view of this topic. In this regard concepts such as newborns feel no pain or older people complain about everything therefore should not be paid attention when referring pain, are being left behind in the understanding that pain alleviation is a human right and everybody feeling pain should be helped for its relief. This book comprises many aspects of pain treatment and the drugs involved in it. From old analgesics with new mechanisms of action for pain alleviation to analgesics potential for diminishing oxidative stress; from pharmacological therapies to electrical ones, going through alternative medicine; and from pain treatment in dentistry to chronic pain therapies, also boarding the treatment of migraine, different experts share their knowledge on the topic.

Go to the book

Pain Relief

Edited by Cecilia Maldonado

Chapters authored

Impact of Severe Sepsis or Septic Shock on Drug Response

By Marta Vázquez, Pietro Fagiolino, Cecilia Maldonado, Manuel Ibarra and Anna Boronat

Part of the book: Severe Sepsis and Septic Shock

Introductory Chapter: Pain Relief - From Analgesics to Alternative Therapies

By Cecilia Maldonado

Part of the book: Pain Relief

Active Pharmacovigilance in Epileptic Patients: A Deep Insight into Phenytoin Behaviour

By Marta Vázquez, Pietro Fagiolino, Cecilia Maldonado, Natalia Guevara, Manuel Ibarra, Isabel Rega, Adriana Gómez, Antonella Carozzi and Carlos Azambuja

Despite the introduction of new and more expensive anticonvulsant drugs, phenytoin (PHT) is still a first-line medication for common types of epilepsy such as tonic-clonic and complex partial seizures but not for absence seizures. PHT shows a nonlinear kinetics and a narrow therapeutic range, thus a fine balance must be found between efficacy and toxic effects. Since the free (unbound) drug is responsible for producing the pharmacological effect, the concentration in a novel biological fluid more closely related to arterial free plasma drug concentration—saliva—is used in this study as part of the monitoring strategy. Therefore, in order to optimize therapy in epileptic patients under PHT treatment, plasma and saliva concentrations of PHT were measured, and adverse drug reactions were registered during a 2-year follow-up. CYP2C9, CYP2C19, and epoxide hydrolase polymorphisms (enzymes involved in PHT metabolism) were also analyzed using, in this way, pharmacogenetics for drug safety. The two PHT brands commercially available in our country and used in this study demonstrated similar pattern of efficacy and safety.

Part of the book: Pharmacovigilance

Cecilia Maldonado

Latest work with IntechOpen by Cecilia Maldonado

Pain Relief

Chapters authored

Related collaborators

Arturo Artero

Jolanta Korsak

Marilena Galdiero

Stefania Galdiero

Marco Cantisani

Annarita Falanga

Rossella Tarallo

Sebastian Lucas

G. Dryllis

E. Digkas