James Paxton

James W. Paxton completed his PhD in steroid biochemistry and porphyria at the University of Glasgow in 1973. He then continued on to a postdoctoral position in the Department of Materia Medica at the same university. In 1976, he was awarded a Merck, Sharpe, and Dohme Fellowship in the Department of Medicine at the University of Auckland, New Zealand. This was followed by a Senior MRC Research Fellowship in the Department of Pharmacology and Clinical Pharmacology and, in 1985, he was appointed as Senior Lecturer in Pharmacology. In 1997, he received the University of Auckland Distinguished Teaching Award and, in 1999, was appointed as Head of the Department. His research interests have primarily focused on ADME and pharmacokinetics, in particular, of novel anticancer agents. Other research interests include placental pharmacology, targeted drug delivery, reversal of MDR, and phytochemical transport. He has written over 160 research papers and reviews published in these areas.

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Latest work with IntechOpen by James Paxton

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

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