Xiaoming Li, MD, PhD is now Professor and Director of Department of Otolaryngology Head & Neck Surgery, Bethune International Peace Hospital, China. He is now the Head of Surgical Head and Neck Oncology Section, Chinese Otolaryngology Head and Neck Surgery Society. His special interest in clinic is surgical management of head and neck cancers including tumor resection and one-stage reconstruction. His expertise in surgical salvage for advanced recurrent head and squamous cell carcinomas (HNSCC) is recognized in that he gave two special talks in round table session on reconstructive surgery for HNSCC and one keynote lecture on salvage surgery of recurrent HNSCC in recent two IFOS world congresses. Over the years, he conducted a series of studies on the clinopathologic features of HNSCC, defining some important factors for predicting metastasis and recurrence. He also devotes himself to in-depth investigation on molecular aspects of tumor invasion and progression, and therapeutic resistance of HNSCC. He was a research scientist from 1999 to 2002 in the National Cancer Institute (NCI), NIH, USA. He was visiting professor of several universities in the world. He published a paper in Nature in 2003 for definition of a new pathway on TNF receptor signaling. His research work is now focusing on genetic manipulations of resistance of HNSCC to chemoradiation by targeting some genes and cell populations such as cancer stem cells.