Xiaoming Li

Xiaoming Li, MD, PhD is now Professor and Director of Department of Otolaryngology Head & Neck Surgery, Bethune International Peace Hospital, China. He is now the Head of Surgical Head and Neck Oncology Section, Chinese Otolaryngology Head and Neck Surgery Society. His special interest in clinic is surgical management of head and neck cancers including tumor resection and one-stage reconstruction. His expertise in surgical salvage for advanced recurrent head and squamous cell carcinomas (HNSCC) is recognized in that he gave two special talks in round table session on reconstructive surgery for HNSCC and one keynote lecture on salvage surgery of recurrent HNSCC in recent two IFOS world congresses. Over the years, he conducted a series of studies on the clinopathologic features of HNSCC, defining some important factors for predicting metastasis and recurrence. He also devotes himself to in-depth investigation on molecular aspects of tumor invasion and progression, and therapeutic resistance of HNSCC. He was a research scientist from 1999 to 2002 in the National Cancer Institute (NCI), NIH, USA. He was visiting professor of several universities in the world. He published a paper in Nature in 2003 for definition of a new pathway on TNF receptor signaling. His research work is now focusing on genetic manipulations of resistance of HNSCC to chemoradiation by targeting some genes and cell populations such as cancer stem cells.

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Latest work with IntechOpen by Xiaoming Li

This book points to some new areas for investigation on squamous cell carcinoma (SCC). Firstly, the features and management of some specific SCC is discussed to give the readers the general principles in dealing with these uncommon and sophisticated conditions. Some new concepts in adjuvant therapy including neoadjuvant therapy and gold nanoparticle-based photo dynamic therapy are introduced. Secondly, a detailed discussion of molecular aspects of tumor invasion and progression in SCC is provided with the emphasis on the roles of some important factors. The role of tumor microenvironment in head and neck SCC is specifically discussed. Thirdly, the roles of cancer stem cells (CSC) in cancer therapy of SCC are described. Molecular mechanisms involving therapeutic resistance and new therapeutic strategies targeting CSC are discussed in detail. Finally, other aspects concerning SCC are included, which involve the assessment, genetic manipulation and its possible clinical implications for the treatment of SCC.

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