Kimberly Payne

Loma Linda UniversityUnited States of America

Dr. Payne translates data obtained using with mice to human systems and uses human systems to answer questions that cannot be addressed in animal models (Immunity26:674, 2007). Dr. Payne developed a novel human-only in vitro model of human B cell development that allows her laboratory to understand factors that are critical in early stages of normal B cell development. Her laboratory used this model to identify IL-7 as an essential cytokine in the B cell production in adults (J Immunol. 2009, 182(7):4255-66). Her group uses this model to study differences in neonatal and adult B cell production and identify cytokines that act cooperatively with Ikaros defects and contribute to the expansion of malignant cells in B cell progenitor acute lymphoblastic leukemia (B-ALL). (J Biol Chem 2008, 283:8291 J Biol Chem. 2009, 284:13869; Leukemia Research. 2010, 34:416.). Dr. Payne's work will provide important information about fetal/neonatal immunity and adult immunity and will serve as a basis for understanding the role of immunity in health disparities that exist at all stages of life

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