",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"9528d3b1ff011d68022c4fa750b4bc24",bookSignature:"Dr. Kieran Richard Hickey",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/8491.jpg",keywords:"Tornadoes Causes, Characteristics, Features, Impacts, Temporal Variability, Spatial Variability, Regional Change, Climate Change, Climatological Context, Trends, Patterns, Projections",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 28th 2020",dateEndSecondStepPublish:"October 26th 2020",dateEndThirdStepPublish:"December 25th 2020",dateEndFourthStepPublish:"March 15th 2021",dateEndFifthStepPublish:"May 14th 2021",remainingDaysToSecondStep:"2 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Dr. Kieran R. Hickey is currently Head of the Department of Geography and also Head of the School of the Human Environment at the University College Cork, in addition, he is a Fellow of the Royal Meteorology Society and the Royal Geographical Society.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"17924",title:"Dr.",name:"Kieran",middleName:"Richard",surname:"Hickey",slug:"kieran-hickey",fullName:"Kieran Hickey",profilePictureURL:"https://mts.intechopen.com/storage/users/17924/images/system/17924.jpg",biography:"Dr. Kieran R. Hickey is a Senior Lecturer in Physical Geography in the School of the Human Environment in University College Cork, Rep. of Ireland where he is currently Head of the Department of Geography and also Head of the School of the Human Environment. He earned his B.A. in Geography and Economics in 1986 and his M.A. in Geography in 1990 from University College Cork, Republic of Ireland and his D.Phil from Coventry University, England in 1997. His research is in storms and hurricanes, climate change, historical climatology and climate disasters. He is a Fellow of the Royal Meteorology Society and the Royal Geographical Society. He has published extensively in many academic journals, edited volumes and written three books, two of which are on weather and climate change.",institutionString:"University College Cork",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University College Cork",institutionURL:null,country:{name:"Ireland"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"10",title:"Earth and Planetary Sciences",slug:"earth-and-planetary-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"9699",firstName:"Iva",lastName:"Lipović",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/9699/images/4740_n.png",email:"iva.l@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"3102",title:"Advances in Hurricane Research",subtitle:"Modelling, Meteorology, Preparedness and Impacts",isOpenForSubmission:!1,hash:"92a1a44953085414828e5969e9ac3434",slug:"advances-in-hurricane-research-modelling-meteorology-preparedness-and-impacts",bookSignature:"Kieran Hickey",coverURL:"https://cdn.intechopen.com/books/images_new/3102.jpg",editedByType:"Edited by",editors:[{id:"17924",title:"Dr.",name:"Kieran",surname:"Hickey",slug:"kieran-hickey",fullName:"Kieran Hickey"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5962",title:"Estuary",subtitle:null,isOpenForSubmission:!1,hash:"43058846a64b270e9167d478e966161a",slug:"estuary",bookSignature:"William Froneman",coverURL:"https://cdn.intechopen.com/books/images_new/5962.jpg",editedByType:"Edited by",editors:[{id:"109336",title:"Prof.",name:"William",surname:"Froneman",slug:"william-froneman",fullName:"William Froneman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"17956",title:"Sexual and Reproductive Function in Chronic Kidney Disease and Effect of Kidney Transplantation",doi:"10.5772/16871",slug:"sexual-and-reproductive-function-in-chronic-kidney-disease-and-effect-of-kidney-transplantation",body:'\n\t\t
\n\t\t\t
1. Introduction
\n\t\t\t
Chronic renal failure has been known to be associated with impotence and loss of libido in men and for many women, infertility and menstrual irregularities. There have been ongoing improvements in survival and quality of life after renal transplantation. These have been accompanied by an improvement in reproductive function and reversal of the relative infertility that occurs despite maintenance hemodialysis. One of the most impressive aspects of successful renal transplantation in the young person is the ability of the male patient to father a child and the female patient to give birth to a healthy baby.
\n\t\t\t
Pregnancy does not appear to have any adverse effect on the long-term survival of renal allografts. Because the outcome of pregnancy in transplantation are so different than those in chronic dialysis, it is advisable to treat end-stage renal disease patients with transplantation and wait until renal function has been stable before undertaking a planned pregnancy. Women are usually advised to wait at least 1 year after living-related kidney Transplantation, and 2 years after cadaveric kidney transplantation; however, waits of 5 years or more have been associated with impaired renal function post-partum.
\n\t\t\t
All women of child-bearing age should be counseled about the possibility and risks of pregnancy after kidney transplantation. Types of immunosuppressive regimens and assessment of graft function should be considered during preconception counseling. Contraceptive counseling should be provided before transplantation surgery, because ovulatory cycles may begin within 1 to 2 months after transplantation in women with grafts that are functioning well. It is strongly advised that every sexually active transplant recipient attend a family-planning counseling session, ideally before transplantation is performed. Breastfeeding is discouraged for patients taking any immunosuppressive drugs.
\n\t\t\t
In this chapter we will first have a short review on reproductive physiology in male and female and irregularities caused by end stage renal disease and then we will review the experience of women undergoing child birth after transplantation, with a focus on outcomes and suggested management strategies including contraception counseling.
\n\t\t
\n\t\t
\n\t\t\t
2. Male reproduction
\n\t\t\t
\n\t\t\t\t
2.1. Physiology of reproduction in men
\n\t\t\t\t
The male reproductive tract consists of the testis, epididymis, vas deference, prostate, seminal vesicles, ejaculatory duct, bulbouretral glands, and urethra. The testes contain two cell types: the Sertoli cells, which line the seminiferous tubules (the site of spermatogenesis), and the Leydig cells (the site of androgen synthesis). In the male, the pituitary gland secretes luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which act on the testes. LH stimulates the synthesis and secretion of testosterone by the Leydig cells, and FSH stimulates the sertoli cells to secrete inhibin. FSH and testosterone act on the seminiferous tubules to stimulate spermatogenesis. In human it takes about 75 days for spermatogonia to develop into mature sperm cells (Berek 2002).
\n\t\t\t\t
During ejaculation, mature spermatozoa are released from the vas deferens along with fluid from the prostate, seminal vesicle, and the bulbourethral glands. The semen released is a gelatinous mixture of spermatozoa and seminal plasma; however it thins out 20 -30 minutes after ejaculation by a process called liquefaction (Berek 2002).
\n\t\t\t\t
Both LH and FSH play roles in normal spermatogenesis. Thus, spermatogenesis does not occur spontaneously in men who have hypogonadotropic hypogonadism of prepubertal onset. Spermatogenesis can be initiated in these men by the administration of human chorionic gonadotropin (hCG), which has potent LH effects, and an FSH preparation, such as human menopausal gonadotropin (hMG) ( Finkel 1985).
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
2.2. Male reproduction in end stage renal disease
\n\t\t\t\t
For many male patients with renal failure, impotence and loss of libido have been seen frequently; these problems may improve but rarely normalize with the institution of maintenance dialysis, commonly resulting in a decreased quality of life ( Holdsworth 1978; \n\t\t\t\t\t\tDiemont 2000\n\t\t\t\t\t; Rosas 2003). By comparison, a well-functioning renal transplant is much more likely to restore sexual activity; however, some features of reproductive function may remain impaired.
\n\t\t\t\t
The uremic milieu plays an important role in the genesis of sexual dysfunction in end stage renal disease. Psychologic and physical stresses that may contribute to disturbances in sexual function are also commonly present in patients with chronic renal failure ( Holdsworth 1978; Steele 1996; Toorians, Janssen et al. 1997).
\n\t\t\t\t
\n\t\t\t\t\t
2.2.1. Gonadal function
\n\t\t\t\t\t
Advanced chronic kidney disease is associated with impaired spermatogenesis and testicular damage ( Holdsworth 1977; Holdsworth 1978). Semen analysis typically shows a decreased volume of ejaculate, oligo- or complete azoospermia, and a low percentage of motile sperm. Testicular histology shows reduced spermatogenic activity varying from decreased numbers of mature spermatocytes to complete aplasia of germinal elements. Other findings include damage to the seminiferous tubules, atrophy of Sertoli cells, and interstitial fibrosis and calcifications.
\n\t\t\t\t\t
The factors responsible for testicular damage in uremia are not well understood. It is possible that plasticizers in dialysis tubing, such as phthalate, may play a role in patients undergoing maintenance hemodialysis.
\n\t\t\t\t\t
Uremia also impairs gonadal steroidogenesis. The serum total and free testosterone concentrations are typically reduced, although the binding capacity and concentration of sex hormone-binding globulin are normal ( Lim 1976; Levitan 1984; de Vries 1984). Another manifestation of diminished testosterone secretory capacity is the subnormal and delayed testosterone response to the administration of human chorionic gonadotropin (HCG), a compound with luteinizing hormone-like actions (Stewart-Bentley 1974). By comparison, although the total plasma estrogen concentration is frequently elevated, the serum estradiol concentration is typically normal (Lim 1978).
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
2.2.2. Pituitary function
\n\t\t\t\t\t
The serum concentration of luteinizing hormone (LH) is elevated in uremic men (Lim 1978); this is due to diminished testosterone feedback.
\n\t\t\t\t\t
Follicle stimulating hormone (FSH) secretion is also elevated, although to a more variable degree ( Holdsworth 1978; de Vries 1984). Elevated FSH levels are probably the result of decreased testosterone and inhibin, a Sertoli cell product. The plasma FSH concentration tends to be highest in those uremic patients with the most severe damage to seminiferous tubules and presumably the lowest levels of inhibin. It has been suggested that increased FSH levels may portend a poor prognosis for recovery of spermatogenic function after renal transplantation. The gonadotropin reserve is generally intact, since the plasma level of both gonadotropins increased appropriately following administration of gonadotropin-releasing hormone (GnRH) (LeRoith 1980). The appropriate increase in FSH and LH in response to the administration of clomiphene (a nonsteroidal antiestrogen that stimulates gonadotropin secretion by blockade of estrogen mediated negative feedback on the hypothalamus) (Lim 1978), also indicates a normal gonadotropin reserve.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
2.2.3. Hyperprolactinemia
\n\t\t\t\t\t
The basal levels of serum prolactin are elevated in the majority of uremic patients, and the response to thyrotropin-releasing hormone (TRH) is reduced and delayed (Hagen C 1976). The mechanisms for the hyperprolactinemia in chronic renal failure are not well defined. Increased autonomous production rate of prolactin is a major mechanism for the hyperprolactinemia but decreased metabolic clearance rate may also play a role (Cowden 1981). The demonstration of resistance to stimulation or suppression of prolactin in CRF is consistent with increased autonomous production (Pece 1979). The state of secondary hyperparathyroidism of CRF may contribute to the increased production rate of prolactin, because PTH stimulates prolactin secretion (Issac 1978). The treatment of CRF patients with erythropoietin was associated with a decreased in serum prolactin levels and improvement in sexual dysfunction (Schaefer, Stanhope et al. 1989), but did not normalize rate of the response to TRH (Ramirez 1976). These observations suggest that either anemia and/or deficiency of erythropoietin per se participate in the genesis of the hyperprolactinemia of CRF.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
2.2.4. Gynecomastia
\n\t\t\t\t\t
Variable degrees of gynecomastia are often encountered in the male uremic patient treated with maintenance hemodialysis (Lim 1978). Gynecomastia usually develops during initial months of dialysis and regresses as dialysis continues. It may be transient or may last for periods of several months. The etiology may be related to the improvement in the nutritional status of uremic patient with dialysis theray and, as such, is similar to the mechanism of refeeding gynecomastia. It must be emphasized that in almost all cases of Gynecomastia, there is an alteration either in the ratio between the serum level of androgen and estrogen, in favor of the latter, or in the ratio between the action of androgen and estrogen at the tissue level ( Sawin 1973). Indeed, in patients with advanced CRF and those treated with hemodialysis, the ratio between the serum levels of free testosterone and estradiol is reduced because of a decreased in testosterone levels.
\n\t\t\t\t
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
2.3. Erectile dysfunction in end stage renal disease:
\n\t\t\t\t
Erectile dysfunction is defined as the inability to achieve and maintain an erection sufficient to permit satisfactory sexual intercourse. It may result from psychologic, neurologic, hormonal, arterial or cavernosal impairment or from a combination of these factors. Most of the studies in sexual dysfunctions in CRF patients have focused on impotence. Erectile dysfunction is common in patients with CRF and is observed in excess of 50% of these patients (Procci 1981). These data are based on results obtained from interviews with or by the completion of questionnaires by the patients and/or their spouses. Several factors appear to participate in the genesis of impotence in CRF patients. These include abnormalities in the neurohormonal control system of erection hormones of the hypothalamic-pituitary-gonadal axis, secondary hyperparathyroidism and, dysfunction of the corporal smooth muscle of the penis or in their response to relaxing stimuli and/or derangements in the arterial supply or the venous drainage of the penis (Schrier RW 2001). Patients with a history of abnormal erectile function prior to the onset of renal disease may have a secondary cause, such as a neuropathy or peripheral vascular disease.
\n\t\t\t\t
The presence of a neurogenic bladder suggests an underlying neuropathy, while findings of peripheral vascular disease point toward inadequate penile blood flow. The lack of secondary sexual characteristics combined with small soft testicles suggests hypogonadism. The ingestion of a number of medications, such as beta blockers and tricyclic antidepressants, may be a cause of erectile dysfunction.
\n\t\t\t\t
Among those without an obvious cause of impotence after an initial evaluation, consideration should be given to a psychologic difficulty, such as stress or depression. The values of Nocturnal Penile Tumescence (NPT) among a large population of uremic patients are significantly lower than normal. The administration of a nocturnal penile tumescence test may help distinguish between an organic and a psychologic disorder; the absence of an erection during sleep suggests underlying organic dysfunction. A positive test, however, does not exclude a physical cause.
\n\t\t\t\t
\n\t\t\t\t\t
2.3.1. Management
\n\t\t\t\t\t
The first step in the treatment of uremic men with sexual dysfunction is increasing the delivered dose of dialysis, discontinuing medications with side effects of impotence and correcting the anemia of chronic renal disease. As an example, the administration of recombinant human erythropoietin to raise the hematocrit to 33 to 36 percent may enhance sexual function ( Delano 1989).
\n\t\t\t\t\t
Sildenafil has been effectively used in the treatment of erectile dysfunction in both hemodialysis and peritoneal dialysis patients and is often used for psychologic, vascular, or neurogenic causes ( Ifudu 1998; Palmer 1999; Turk 2001; Seibel 2002; Rosas 2003; Grossman 2004). Concurrent use of sildenafil and nitrates in any form, regularly or intermittently, is contraindicated.
\n\t\t\t\t\t
Since the elevation of serum levels of prolactin plays a role in the impotence of male uremic patient, correction of hyperprolactinemia by bromocriptin is also associated with improvement of sexual dysfunction.
\n\t\t\t\t\t
Cabergoline, which causes nausea much less often than does bromocriptine and is at least as effective in treating hyperprolactinemia, should be tried first (Biller BM; Molitch ME; Vance ML; Cannistraro KB; Davis KR; Simons JA; Schoenfelder JR; Klibanski A 1996 ). The administration of testosterone to uremic men usually fails to restore libido or potency, despite normalized serum testosterone.
\n\t\t\t\t\t
A vacuum tumescence device may be effective in restoring potency in uremic impotent males unresponsive to medical therapy. Administration of zinc is also a reasonable therapeutic option in uremic men.
\n\t\t\t\t
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
2.4. Renal transplantation
\n\t\t\t\t
Kidney transplantation is the best and most effective option that can be offered to patients with severe renal damage to restore their health and the possibility of recovering their sexual and reproductive functions.
\n\t\t\t\t
After successful transplantation, about two thirds of male patients observe improved libido and a return of sexual function to predialysis levels. Fertility as assessed by sperm counts, improves in half patients. The sex hormone profile tends to normalize; plasma testosterone and follicle stimulating hormone levels increase; and luteinizing hormone levels which may be high in dialysis patients, decrease to normal or low levels (Danovitch GM 2005).
\n\t\t\t\t
The factors that might cause certain difficulties for the recovery of sexual and reproductive functions in this type of patients include prolonged use of peritoneal dialysis, high follicle stimulating hormone (FSH) serum levels before the transplant, and a deficient function of the graft (De Celis and Pedron-Nuevo 1999).
\n\t\t\t\t
A certain improvement has been reported as to semen quality in the three main parameters (number, morphology, and motility of the spermatozoa) in patients after kidney transplantation (De Celis and Pedron-Nuevo 1999).
\n\t\t\t\t
Several studies conducted to evaluate the effects of immunosuppressive regimens suggest that some of these agents are potentially gonadotoxic since they affect testicular function and decrease fertility. This is mainly due to an indirect effect on the hypothalamus–pituitary–gonadal axis, or directly suppressant on the germinal epithelium of the testis, where the spermatogenetic process is primarily affected because of an interruption of the cycle needed for the development of an adequate amount of normal spermatozoa.
\n\t\t\t\t
This would result in oligo/asthenozoospermia, teratozoospermia, or azoospermia. Cyclosporine (CSA) is an important therapeutic agent and a common component in multiple immunosuppressive regimens used in recipients of kidney transplants and for a growing number of autoimmune disorders. Some studies imply that CSA is a potentially gonadotoxic drug, producing adverse effects on the reproductive capability in experimental models as well as in humans. In certain animal species, such as the Sprague–Dawley strain rats, Seethalakshmi et al. showed that the administration of CSA induces a deficient intratesticular synthesis of androgens and a reduction in spermatogenesis, although this reduction was reversible after exogenous gonadotrophins were administered (\n\t\t\t\t\t\tSeethalakshmi 1990\n\t\t\t\t\t). On the other hand, it has also been possible to observe the adverse effect of CSA by means of testicular biopsies performed in dogs (Seethalakshmi 1988) and rats (Seethalakshmi 1990) treated with CSA for short periods, where marked abnormalities in spermatogenesis were seen. Cyclosporine (CSA) may impair testosterone biosynthesis through direct damage to leydig cells and germinal cells, an indirect impairment of the hypothalamic-pituitary-gonadal axis has also been suggested.
\n\t\t\t\t
Computer-aided sperm analysis (CASA) in infertile renal transplant recipients showed that both sperm concentration and straight line velocity (VSL) were inversely correlated to the cyclosporine whole blood trough levels. Stabilization of the cyclosporine whole blood trough level within the target therapeutic level could improve the fertility potential in kidney transplant recipients. Duration of hemodialysis before transplantation is also important in this regard. The time spent on hemodialysis is inversely correlated with the percentage of motile spermatozoa and the amplitude of lateral head displacement (ALH) (Eid, Abdel-Hamid et al. 1996).
\n\t\t\t\t
Azathioprine (AZA), another drug that is frequently combined with CSA, is considered to be genotoxic (Olshan 1994). However, very few studies have analyzed the effects of AZA on the reproductive function of humans. Several studies suggest that prednisone might not be involved in sperm cell damage.
\n\t\t\t\t
Kaczmarek and coworkers found that heart transplant recipients treated with sirolimus had significantly lower free testosterone levels and significant higher levels of gonadotropic hormones luteinizing hormone and follicle-stimulating hormone compared with calcineurin inhibitor-based immunosuppression group (Kaczmarek 2004). Patients treated with sirolimus throughout the post-transplant period have a significantly reduced total sperm count compared to patients who did not receive sirolimus and a decreased proportion of motile spermatozoa. Moreover, the fathered pregnancy rate was lower in patients receiving sirolimus-based regimens (Zuber, Anglicheau et al. 2008).
\n\t\t\t\t
There is also concern about infertility associated with Ganciclovir which is used for treatment of cytomegalovirus (CMV) infection in transplant patients (Nevins and Dunn 1992). There is no increased incidence of neonatal malformations in pregnancies fathered by transplant recipients (Danovitch GM 2005).
\n\t\t\t\t
\n\t\t\t\t\t
2.4.1. Sexual functions in renal transplant patients
\n\t\t\t\t\t
Renal transplant recipients have all suffered from uremia. They have frequently spent a significant amount of time on dialysis and often have other comorbidities including hypertension and diabetes. Although a successful transplant may improve erectile function and return of libido, in many cases some degree of sexual dysfunction may persist. On the contrary a recent study showed that, erectile function worsens after RT in patients<45 yr (Mirone, Longo et al. 2009).
\n\t\t\t\t\t
Hypertension is common among transplant patients; CSA can exacerbate preexisting high blood pressure and also induce hypertension in patients, who had normal blood pressure prior to the kidney transplant.
\n\t\t\t\t\t
Antihypertensive medications have negative effects on male sexual functions, such as libido and erection (Matthew RW 2005). Those medications which are implicated in erectile dysfunction include beta blockers (propranolol, labetalol), Alpha blockers (prazosin), sympatholytics (clonidine), vasodilators (hydralazine), and diuretics (thiazides, spironolactone).
\n\t\t\t\t\t
Other drugs which may also play a role in erectile dysfunction in transplant patients are: HMG- CoA reductase inhibitors (lovastatin, simvastatin), antidepressant (serotonin reuptake inhibitors, tricyclics, monoamine oxidase inhibitors) and H2 antagonists (cimetidine, ranitidine, famotidine).
\n\t\t\t\t\t
Ketoconazole which is used in some transplant centers in order to increase cyclosporine level and reducing the cost of calcineurin inhibitors can cause erectile dysfunction because of its antiandrogenic action.
\n\t\t\t\t\t
Additional factors such as smoking and alcohol intake may account for failure of male sexual function to improve after transplantation.
\n\t\t\t\t\t
Cigarette smoking may induce vasoconstriction and penile venous leakage because of its contractile effect on the cavernous smooth muscle (Juenemann 1987). Alcohol in small amounts improves erection and increases libido because of its vasodilatory effect and the suppression of anxiety; however, large amounts can cause central sedation, decreased libido, and transient erectile dysfunction. Chronic alcoholism may cause hypogonadism and polyneuropathy, which may affect penile nerve function (Miller 1988).
\n\t\t\t\t\t
Autonomic neuropathy may impair erectile function, and interruption of both hypogastric arteries may occasionally impair vascular supply.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
2.4.2. Management of erectile dysfunction in transplant patients
\n\t\t\t\t\t
Male patients should be asked about their sexual function and referred for urologic evaluation when necessary. Historically, androgens were touted as enhancing male sexual function. Today, more effective treatments are available, and testosterone therapy should be discouraged in men in whom erectile dysfunction is not associated with hypogonadism (Lue T F 2000). Sildenafil is a selective inhibitor of phosphodiesterase type 5, which inactivates cyclic GMP. Since its release in March 1998, it has become the drug of choice for most men with erectile dysfunction. When sexual stimulation releases nitric oxide into the penile smooth muscle, inhibition of phosphodiesterase type 5 by sildenafil causes a marked elevation of cyclic GMP concentrations in the glans penis, corpus cavernosum, and corpus spongiosum, resulting in increased smooth-muscle relaxation and better erection. Sildenafil has no effect on the penis in the absence of sexual stimulation, when the concentrations of nitric oxide and cyclic GMP are low (Lue T F 2000). Sildenafil has little effect on libido. Among more than 3700 men with 1631 patient years of exposure to sildenafil, most adverse events were mild to moderate and self-limited in duration (Esteban de la Rosa, Bravo Soto et al. 2003). Among men taking 25 to 100 mg of sildenafil, 16 percent reported headache, 10 percent flushing, 7 percent dyspepsia, 4 percent nasal congestion, and 3 percent abnormal vision (described as a mild and transient color tinge or increased sensitivity to light). These rates were twice as high among men taking 100 mg of sildenafil as among men who were taking lower doses. The visual effect is probably related to inhibition of phosphodiesterase type 6 in the retina. No chronic visual impairment has been reported, and the incidence of visual side effects was similar in diabetic and nondiabetic men (Price 1998). Nevertheless, because of the short duration of the clinical trials and the difficulty in detecting subtle retinal changes, the long-term safety of sildenafil treatment is still unknown. In men with retinal diseases, an ophthalmologic consultation may be warranted before sildenafil treatment is initiated. Adverse cardiovascular events (nasal congestion, headache, and flushing) were mild and transient in the majority of men. The rate of serious cardiovascular events (angina and coronary-artery disorder) is low. Sexual activity was thought to be a likely contributor to myocardial infarction in only 0.9 percent of 858 men in one study (Muller, Munder et al. 2009). Thus, the absolute increase in risk caused by sexual activity is low (one chance in a million for a healthy man). According to data from the National Center for Health Statistics and the Framingham Heart Study, the rate of death from myocardial infarction or stroke for men in the age range in which erectile dysfunction is common is approximately 170 per million men per week. Therefore, it appears that sildenafil therapy is safe for most men. Nevertheless, given that most of the men who died had underlying cardiovascular disease; cardiovascular status should be carefully assessed before treatment. The combination of nitrates and sildenafil has resulted in severe hypotension and 16 deaths in the United States. Therefore, nitrate therapy is an absolute contraindication to sildenafil therapy (Lue T F 2000).
\n\t\t\t\t\t
Sildenafil is absorbed well during fasting, and the plasma concentrations are maximal within 30 to 120 minutes (mean, 60). It is eliminated predominantly by hepatic metabolism, and the terminal half-life is about four hours. The recommended starting dose is 50 mg taken one hour before sexual activity. The maximal recommended frequency is once per day. On the basis of effectiveness and side effects, the dose may be increased to 100 mg or decreased to 25 mg (Lue T F 2000). There is no specific contraindication to use of sildenafil (Viagra) in transplant patients so long as standard precautions are taken regarding concomitant coronary artery disease.
\n\t\t\t\t\t
Oral vardenafil (Phosphodiesterase-5 Enzyme Inhibitor) therapy has a high efficacy and a low incidence of adverse events for kidney transplant recipients with ED (Yang, Ju et al. 2008). Vardenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE-5), which is responsible for degradation of cGMP in the corpus cavernosum; when sexual stimulation causes local release of NO, inhibition of PDE-5 by vardenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. so it can prolong erectile duration of ED patients (Wang and Huang 2009); at recommended doses, it has no effect in the absence of sexual stimulation.
\n\t\t\t\t\t
Transurethral administration of alprostadil (synthetic form of prostaglandin E1) or intracavernous injection resulting in an erection sufficient for intercourse has been used successfully. The most effective intracavernous therapy used is a three-drug mixture containing papaverine, phentolamine, and alprostadil (trimix). The usual dose of trimix solution ranges from 0.1 to 0.5 ml. The rate of response to this solution is as high as 90 percent (Bennett 1991). In case of drug treatment failure, penile prosthesis can be considered even in transplanted patients (Lasaponara, Pasquale et al. 2009; Phe, Roupret et al. 2009).
\n\t\t\t\t
\n\t\t\t
\n\t\t
\n\t\t
\n\t\t\t
3. Female reproduction
\n\t\t\t
\n\t\t\t\t
3.1. Menstrual cycle
\n\t\t\t\t
The menstrual cycle is a hormonally controlled process of events occurring through the hypothalamic-pituitary-ovarian axis and reflected by the histological changes in the endometrium.
\n\t\t\t\t
The normal menstrual cycle is a tightly coordinated cycle of stimulatory and inhibitory effects that results in the release of a single mature oocyte from a pool of hundreds of thousands of primordial oocytes.
\n\t\t\t\t
The menstrual cycle lasts 25 to 30 days in most women. It is divided into two successive phases: the follicular phase and the luteal phase. By convention, the day of menstruation is designated as day 1 of the menstrual cycle. The luteal phase is remarkably constant in length and lasts 13 to 15 days, but length of the follicular phase is variable. The average duration of flow is 4 to 6 days but can be as few as 2 days and as many as 7 days. A flow of longer than 7 days deserves evaluation (Higham 1990).The average blood loss during one menses is about 30 mL. A flow of 80 mL or more can lead to anemia and should be evaluated (Cohen and Galbraith 2001). However, it is not necessary to measure menstrual flow; a patient\'s perception of abnormal menses deserves evaluation and treatment.
\n\t\t\t\t
By definition menorrhagia is excessive and prolonged uterine bleeding at regular intervals; metrorrhagia is irregular, intermenstrual bleeding. Menometrorrhagia is heavy, prolonged, irregular bleeding at frequent, irregular intervals. Polymenorrhea is frequent, regular episodes of uterine bleeding at intervals of less than 21 days. Oligomenorrhea is irregular bleeding occurring at prolonged intervals of more than 35 days. Amenorrhea is absence of uterine bleeding (Sciarra J 2001).
\n\t\t\t\t
There is relatively little cycle variability among women between the ages of 20 and 40 years. In comparison, there is significantly more cycle variability for the first 5 to 7 years after menarche and for the last 10 years before cessation of menses (Treloar 1967).
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.2. Menstrual cycle irregularities in end stage renal disease
\n\t\t\t\t
Menstrual problem is common among women with renal insufficiency. It is partly because of abnormal bleeding time due to platelet dysfunction and also because of failure to ovulate or sustain adequate corpus luteum function.
\n\t\t\t\t
Amenorrhea is common by the time the patient reaches end-stage renal disease. The menstrual cycle typically remains irregular with scanty flow after the initiation of maintenance dialysis, although normal menses are restored in some women( Holley 1997) In others, menorrhagia develops, sometimes leading to significant blood loss and increased transfusion requirements.
\n\t\t\t\t
Oligo/ anovulation is the major factor for these menstrual cycle abnormalities in uremic women. Uremia is associated with hypothalamic-pituitary-gonadal dysfunction.
\n\t\t\t\t
Leptin is one of the responsible factors involving in this cycle abnormality. In general, serum leptin levels are significantly elevated in patients with renal failure, particularly when compared to age and body mass index (BMI)-matched controls ( Wolf 2002). Leptin appears to be one of several factors that influence the maturation of the gonadotropin-releasing hormone (GnRH) pulse generator.
\n\t\t\t\t
Hyperprolactinemia is common in women with chronic renal failure due to increased secretion and decreased metabolic clearance of this hormone ( Sievertsen 1980). The elevated prolactin levels may impair hypothalamic-pituitary function and contribute to sexual dysfunction and galactorrhea in these patients. Although kidney transplantation greatly improves menstrual pattern, but irregular bleeding is still a major problem among women with a transplanted kidney. In a study on 114 women with a transplanted kidney we found normal menstruation in 49%, oligo/ hypomenorrhea or amenorrhea in 31.3% and hypermenorrhea in 19.8% (\n\t\t\t\t\t\tLessan-Pezeshki, Ghazizadeh et al. 2004\n\t\t\t\t\t).
\n\t\t\t\t
In order to reduce the chance of endometrial hyperplasia that results from chronic stimulation of the endometrium with estradiol, medroxyprogesterone acetate (Provera), 10 mg/day orally for 5 days is prescribed. Patients with adequate endogenous estrogens will bleed within 3 to 5 days after medication, indicating adequate endogenous estrogen stimulation of the endometrium. Patients with relatively low levels of endogenous estrogens may have a limited response to the progesterone challenge.
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.3. Sexual dysfunction in uremic women
\n\t\t\t\t
Sexual desire or drive is defined as the frequency or intensity with which a person desires to participate in sexual activity. Both organic and psychological variables contribute to this interest. Hormones can act on sexual behavior indirectly by influencing general mood. They can influence sexual interest levels by their peripheral action, such as by increasing genital vasocongestion and sexual sensation or by enhancing the sexual attractiveness of the female by means of smell. Women receiving chronic dialysis tend to experience decreased libido and reduced ability to reach orgasm.
\n\t\t\t\t
Uremic patient\'s sexual difficulties are often worsened by hemodialysis, with a lowered frequency of intercourse, reduced sexual desire, and an increased incidence of sexual failure (Thurm JA 1976 ). Initial treatment goals for uremic women with sexual dysfunction include increasing the adequacy of dialysis, and correcting the anemia of chronic renal failure.
\n\t\t\t\t
Amenorrheic dialysis patients may have low estradiol levels; this may lead to vaginal atrophy and dryness, thereby resulting in discomfort during intercourse. Such patients may benefit from local estrogen therapy or vaginal lubricants. Successful transplantation is clearly the most effective means to restore normal sexual desire in women with chronic renal failure ( \n\t\t\t\t\t\tDiemont 2000\n\t\t\t\t\t). Sexual desire increases significantly after successful transplantation in most patients, however improvement in frequency of sexual activity and overall sexual satisfaction is not as high as sexual desire.
\n\t\t\t\t
Low dose testosterone may be effective but, due to potential toxicity, is rarely used. The administration of bromocriptine may help restore sexual function in those with hyperprolactinemia.
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.4. Pregnancy in end stage renal disease
\n\t\t\t\t
Fertility is reduced in the presence of end-stage renal disease. Conception is rare for women on dialysis, and occurs at a rate of one in every 200 patients (Rizzoni, Ehrich et al. 1992). Pregnancy is often diagnosed late because of menstrual irregularities; thus, early spontaneous abortion may be overlooked. The diagnosis of pregnancy may be difficult in women with end-stage renal disease; particularly because serum levels of beta-human chorionic gonadotropin (beta-hCG) may be increased in the absence of pregnancy. The main risks for a fetus include death, prematurity, and growth retardation. A review by Hou of 37 pregnancies associated with chronic renal dialysis found that 75% to 80% resulted in spontaneous abortion, stillbirth, or neonatal death. (Hou S 1987) Placental abnormalities included abruption, infarction, and microscopic areas of necrosis. No developmental abnormalities were reported, and the incidence of congenital abnormalities appeared to be no greater than for normal pregnancies.
\n\t\t\t\t
Hypertension is a major problem and may prove very difficult to control. Forty-nine percent of the patients reviewed by Hou became hypertensive during pregnancy. The infants of hepatitis carriers should receive hepatitis B immune globulin and vaccine in the first 72 hours to avoid becoming carriers.
\n\t\t\t\t
Since 1976, chronic ambulatory peritoneal dialysis (CAPD) has been increasingly used to manage end-stage renal failure. It has several theoretical advantages over hemodialysis for the management of pregnant patients (Mahanty, Cherikh et al. 2001). A more constant intrauterine environment without rapid shifts in fluid, solutes, and electrolytes may benefit a fetus, Redrow compared eight pregnancies managed with peritoneal dialysis with seven managed with hemodialysis (Redrow 1988 ). Hypotensive episodes appear to be less frequent, hematocrits higher, and control of insulin and glucose levels more exact in the group on peritoneal dialysis. Further experience is needed to determine if this is the preferred mode of dialysis in pregnancy. If peritoneal dialysis is used, the exchange volumes should be decreased (eg, to 1.5 liters) and the frequency should be increased (Jungers and Chauveau 1997).
\n\t\t\t\t
\n\t\t\t\t\t
3.4.1. Management
\n\t\t\t\t\t
An increased dose of dialysis appears to be beneficial, with reports of Kt/V values of 6 to 8, on hemodialysis 5-6 days per week (Henrich WL 2004), with the BUN being maintained at under 50 mg/dL or even under 45 mg/dL. Ameliorating the uremic milieu can avoid polyhydramnios, help control hypertension, and improve maternal nutrition. Increased doses of erythropoietin are required to maintain hemoglobin levels in an acceptable range (10 to 11 g/dl) and transfusions are sometimes required (Chao 2002). Protein intake should be 1 g/kg per day plus an additional 20 g/day for fetal growth. Diet should be supplemented with water soluble vitamins and zinc. Metabolic acidosis and hypocalcemia should be corrected. Careful uterine and fetal monitoring during hemodialysis, such as assessment of the fetal heart rate (particularly during the last portion of a session), combined with measures aimed at preventing dialysis-induced hypotension should be performed. In many cases, patients are hospitalized around week 20 of gestation for management of blood pressure, dialysis fluid balance, nutrition and anemia.
\n\t\t\t\t\t
If peritoneal dialysis is used, the exchange volumes should be decreased (eg, to 1.5 liters) and the frequency should be increased.
\n\t\t\t\t
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.5. Pregnancy in renal transplantation
\n\t\t\t\t
Fertility is usually restored in women with renal transplants and pregnancy is common, occurring in 12% of women at childbearing age in one series (Sturgiss and Davison 1995). Pregnancy success rate exceeds 90% after the first trimester. The recovery of fertility is less common in women who undergo transplantation close to the end of their childbearing years (Hou S 1987). The first reported successful pregnancy occurred in a recipient of a kidney transplant from an identical twin sister performed in 1958 (Murray 1963). Since then, there have been hundreds of successful pregnancies reported in renal transplant recipients (Davison JM 1987). During the last decade there has been a steady increase in the number of pregnancies following renal transplantation (Sgro, Barozzino et al. 2002).
\n\t\t\t\t
Pregnancy in transplant recipients provides an opportunity to investigate biological processes that may have an impact on graft outcome as well as pregnancy outcome. For example, immunologic adjustments are believed to be involved in implantation as well as a successful acceptance of the allogenic fetus by their mother (Matthew RW 2005).
\n\t\t\t\t
\n\t\t\t\t\t
3.5.1. Effect of pregnancy on graft function
\n\t\t\t\t\t
Although pregnancy can cause an increase in the glomerular filtration rate, which could theoretically lead to hyperfiltration and resultant glomerulosclerosis, the hyperfiltration of pregnancy is flow related, with no concomitant increase in intraglomerular pressure (Denton and Baylis 2007).
\n\t\t\t\t\t
In cyclosporine treated patients, graft dysfunction after pregnancy was seen in patients with higher mean serum creatinine levels and lower mean cyclosporine doses prior to conception (ArmentiVT, Radomski JS et al. 2000). Overall, in the majority of recipients studied, pregnancy does not appear to cause excessive or irreversible problems with graft function if the function of transplant organ is stable prior to pregnancy (Armenti, Constantinescu et al. 2008).
\n\t\t\t\t\t
The long-term effect of pregnancy on renal function is less clear. Two small studies in which matched nonpregnant controls were used found conflicting results: no deleterious effect in one with 15 year follow-up; and an increase in the plasma creatinine concentration of 0.5 to 0.7 mg/dL at 3 to 12 months in the other (Salmela, Kyllonen et al. 1993; Sturgiss and Davison 1995). The latter report also suggested that a second pregnancy might carry a greater risk, as renal function deteriorated in three of seven women (Salmela, Kyllonen et al. 1993).
\n\t\t\t\t\t
The incidence of acute rejection is not greater than expected for non-pregnant transplant patients. The incidence of acute rejection during pregnancy and three months after delivery varies between 9 and 14.5% in the published series. Rejection is sometimes difficult to diagnose and an ultrasound-guided biopsy may be helpful to diagnose acute pyelonephritis, recurrent glomerulonephritis, and severe pre-eclampsia. Renal biopsy should be performed before starting anti-rejection therapy, and high steroid doses are the first line of treatment. It has been suggested that acute rejection during the puerperium may be due to a return to a normal immune status or to a rebound effect from the altered gestational immune responsiveness. Therefore, immunosuppression should be re-adjusted immediately after delivery.
\n\t\t\t\t
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.6. Immunosuppressive drugs in pregnancy
\n\t\t\t\t
Immunosuppression in pregnancy is a concern from the perspective of both maternal and fetal safety issues. Blood volume and volume of distribution increase during pregnancy thus blood levels of immunosuppressive drugs are often lower, though there is no evidence that effective immunosuppression is inadequate if prepregnancy doses are used. We currently have limited information regarding the toxicities and teratogenic potentials of these agents, although our knowledge has recently increased as more women maintained on immunosuppressive therapy for solid organ transplants have opted to become pregnant.
\n\t\t\t\t
\n\t\t\t\t\t
3.6.1. Glucocorticoids
\n\t\t\t\t\t
The most commonly used glucocorticoids are the short acting agents; prednisone, prednisolone and methyl prednisolone. Radiolabaled prednisone and prednisolone can cross the placenta, but maternal / cord blood ratios are approximately 10:1 (Beitins 1972). In utero exposure to high-dose steroid and immunosuppressive agents does not seem to be associated with an increased incidence of congenital anomalies in the offspring of pregnant women with a renal transplant. Adrenal insufficiency and thymic hypoplasia have occasionally been described in the infants of transplant recipients, but these problems are unlikely if the dose of prednisone has been decreased to 15 mg. Cases of cleft palate, mental retardation, have also been described in humans after in utero corticosteroid exposure. Glucocorticoid therapy during pregnancy can result in premature rupture of the membranes (PROM) and intrauterine growth restriction. The increased risk of PROM with prednisone therapy likely reflects the inhibitory effects of glucocorticoids on fetal membrane extracellular matrix synthesis. Alternatively, PROM may be the result of prednisone\'s stimulatory effects on fetal membrane, placental, and decidual corticotropin releasing hormone. Furthermore, pregnancy-induced hypertension, gestational diabetes, and osteoporosis can be exacerbated.
\n\t\t\t\t\t
Doses of prednisone greater than 20 mg/d have been associated with serious maternal infection, however treatment of rejection with steroids, if necessary, should not be avoided during pregnancy (Lessan-Pezeshki M 2002).
\n\t\t\t\t\t
Current data suggest that steroids and immunosuppressive agents in the doses used to prevent graft rejection in transplant recipients are well tolerated by the fetus. Long-term studies are required to determine whether there may be other effects, particularly an increase in the incidence of malignancies or abnormalities in the subsequent generation.
\n\t\t\t\t\t
FDA rates the risk of prednisone use in pregnancy as C which implies that "Risks can not be ruled out".
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.6.2. Azathioprine
\n\t\t\t\t\t
Azathioprine is an antimetabolite, an imidazole derivative of 6- mercaptopurine. It is commonly used during pregnancy in transplant recipients. Radioactive labeling studies in humans have shown that 64 - 93 percent of azathioprine administered to mothers appears in fetal blood as inactive metabolites (Sarikoski 1973). Azathioprine can cause transient gaps or breaks in lymphocyte chromosomes. Germ cells and other tissues have not been studied. In the adult, azathioprine is metabolized to 6- mercaptopurine. The immature fetal liver lacks the enzyme inosinate pyrophosphorylase, needed for conversion, and the fetus is relatively protected from the effects of the drug (Lessan-Pezeshki M 2002). The desired drug dose of azathioprin is 2 mg/kg/day or less. In high doses (6 mg/kg), azathioprine is teratogenic in animals. In human studies low birth weights, prematurity, jaundice, respiratory distress syndrome and aspiration have been reported in kidney transplant recipients. Azathioprine has been associated with a dose related myelosuppression in the fetus, but leukopenia is not usually a problem in the neonate if the maternal white blood count is maintained at greater than 7500 /mm3 (Armenti, Constantinescu et al. 2008).
\n\t\t\t\t\t
FDA rated azathioprine use during pregnancy as D which implies that "positive evidence of risk exists but potential benefit may outweigh the risk"
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.6.3. Cyclosporine
\n\t\t\t\t\t
Cyclosporine is a small cyclic polypeptide of fungal origin that inhibits calcineurin. There is little or no transplacental passage of cyclosporine in rodents (Safwenberg, Backman-Bave et al. 1977). In comparison, there are conflicting reports on the transfer of cyclosporine across the human placenta. Studies in pregnant rats have generally shown no effect of cyclosporine on organogenesis, although some renal proximal tubular cell damage can occur (Bailie, Elder et al. 2007). Human data showed that administration of cyclosporine was associated with low birth weights and a higher incidence of maternal diabetes, hypertension and renal allograft dysfunction. Cyclosporine metabolism appears to be increased during pregnancy and higher doses may be required to maintain plasma levels in the therapeutic range (Murirhead 1992). In women several years post-transplant with stable renal function, the pre-pregnancy dose can be continued. Some of the pregnancies in cyclosporine- treated women were complicated by preeclampsia. Cyclosporine increases production of thromboxane and endothelin, which have both been implicated in the pathogenesis of preeclampsia. Because of this, some physicians have suggested that the dose be limited to 2 to 4 mg/kg per day (Lindheimer Md and 1992).
\n\t\t\t\t\t
Although the safety of cyclosporine is not well established in pregnancy, but it does not appear to be a major teratogen, as suggested by the results of a meta-analysis of 15 studies (Bar Oz 2001 ).
\n\t\t\t\t\t
FDA rates the risk of cyclosporine use in pregnancy as C.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.6.4. Tacrolimus
\n\t\t\t\t\t
Tacrolimus is another calcineurin inhibitor. Experience with tacrolimus in pregnancy is limited. Among 100 pregnancies in 84 women treated with tacrolimus, of whom 27 percent were renal transplant recipients, 68 progressed to a live birth, with 60 percent of deliveries being premature (Kaniz and 2000). It has been associated with neonatal hyperkalemia. As with cyclosporine, patients taking tacrolimus require frequent monitoring of renal function and drug levels. During pregnancy, the hepatic cytochrome p450 enzymes may be inhibited, which can lead to increased serum level of tacrolimus. The dose may therefore have to be significantly reduced to prevent toxicity (sometimes as much as 60 %) (Lessan-Pezeshki M 2002).
\n\t\t\t\t\t
FDA rates the risk of tacrolimus use in pregnancy as C.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.6.5. Mycophenolate Mofetil (MMF)
\n\t\t\t\t\t
MMF is a selective antimetabolite which impairs lymphocyte function by blocking purine biosynthesis via inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolate was developed as a replacement for azathioprine for maintenance immunosuppression. It is not nephrotoxic, and has less bone marrow toxicity than azathioprine.
\n\t\t\t\t\t
MMF has been reported to cause head and eye malformations in the offspring of rat. Reported experience in human pregnancy with MMF is limited. There have been birth defects in few cases, but current data are insufficient to determine incidence of specific malformation. Among the 14 MMF-exposed offspring that has been reported, the underlying maternal conditions were kidney transplantation (N=7), lupus nephritis (N=4), liver transplantation, heart transplantation, and recurrent erythema multiforme. All were exposed in early pregnancy. The most distinctive malformation was moderate-to-severe microtia or anotia in 12, with external auditory canal atresia in 9. Other common craniofacial malformations and minor anomalies included orofacial clefts, hypertelorism, coloboma, and micrognathia. Six had cardiovascular malformations, of which three were either conotruncal or aortic arch defects (Anderka, Lin et al. 2009).
\n\t\t\t\t\t
The manufacturer of MMF recommends that women of child-bearing age should have a negative pregnancy test prior to the initiation of therapy. We currently recommend that allograft recipients who wish to conceive should change from MMF to azathioprine, if there are no contraindications to the switch. MMF should be stopped 6 weeks prior to conception.
\n\t\t\t\t\t
FDA rates the risk of MMF use in pregnancy as D.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.6.6. Sirolimus
\n\t\t\t\t\t
Sirolimus is a macrolide antibiotic compound that is structurally related to tacrolimus. Following entry into the cytoplasm, sirolimus binds to the FK binding protein and presumably modulates the activity of the mammalian target of rapamycin (mTOR). The mTOR inhibits interleukin-2 mediated signal transduction, resulting in cell cycle arrest in the G1-S phase (Danovitch GM 2005). It causes delayed ossification in animal reproductive studies, and its use is contraindicated in human until more data are available. Its use should also be discontinued at least 6 weeks prior to attempted conception.
\n\t\t\t\t\t
In general, we recommend that women post-transplant who wish to conceive be switched prior to conception from sirolimus to cyclosporine. Upon delivery, it is recommended to switch the mother back to her basal immunosuppression in view of the potential benefits of the newer agents to prevent late acute rejection and chronic allograft nephropathy.
\n\t\t\t\t\t
FDA rates the risk of sirolimus use in pregnancy as C.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.6.7. OKT3 and polyclonal antibodies
\n\t\t\t\t\t
OKT3 is a mouse antibody licensed for antirejection therapy, being directed against the CD3 antigen that is closely associated with the T cell receptor. It crosses the placenta. The National Transplantation Pregnancy Registry (NTPR) has reported the treatment of five women with OKT3 during pregnancy, with four surviving infants (Eisenberg 1997). The effect of polyclonal antibodies on the developing fetus is not known, but the IgG component would be expected to cross the placenta.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.6.8. Intravenous Immune Globulins (IVIG)
\n\t\t\t\t\t
Pooled human gamma-globulin preparations which were initially developed for the treatment of humoral immune deficiency disorders, proving to be invaluable in certain defined situations in clinical transplantation when used alone or in combination with plasmapheresis, such as antibody mediated rejection (Danovitch GM 2005). IgG is selectively transported across the placenta and the amount transferred increases with gestational age and dose. No cases of human deficiency virus (HIV) transmission have been reported with the use of IVIG, but adverse effects include thrombosis, alopecia, liver function disturbances, transient neutropenia, chills, nausea, flushing, tightness of chest and anaphylactic reaction in those with IgA antibodies.
\n\t\t\t\t\t
There is little information regarding the teratogenicity of IVIG in animals. One report showed that IVIG was well tolerated in pregnant mice with induced antiphospholipid antibody syndrome (Bakimer 1993). In humans, IVIG appears to cross the placenta after 32 weeks of gestation, even after modification that alters the Fc binding sites ( Hockel 1986). There have been no reports of fetal malformations in humans. However, IVIG is not completely benign, since hemolytic disease of the newborn and transmission of hepatitis C has been reported in selected cases.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.6.9. Leflunomide
\n\t\t\t\t\t
Leflunomide is an antimetabolite with both immunosuppressive and antiviral activities. It has been used successfully in the treatment of polyoma virus nephropathy (Danovitch GM 2005). It has marked teratogenic properties.
\n\t\t\t\t\t
FDA rates its use during pregnancy as X. This medication should not be used during pregnancy or breast feeding.
\n\t\t\t\t
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.7. Management of pregnancy in kidney transplant patient\'s guidelines:
\n\t\t\t\t
All women of childbearing age should be counseled concerning the possibility and risks of pregnancy after kidney transplantation. Women who are not rubella immune should receive the rubella vaccine before transplantation, because live virus vaccines are contraindicated post transplantation (Hou S and 1999). Women are usually advised to wait at least one year after living related donor transplantation and two years after cadaveric renal transplantation (Lessan-Pezeshki M 2002). However, waiting 5 or more years may result in impaired renal function post partum that fails to recover, because of gradually deteriorating renal function secondary to chronic allograft nephropathy.
\n\t\t\t\t
Criteria that should be ideally met before conception are shown in table 1.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\tAt least 1 year post transplantation\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\tStable renal function with creatinine< 1.5 mg/dl\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\tNo recent episodes of acute rejection\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\tBP < 140/90 mmHg on medications\n\t\t\t\t\t\t\t
Criteria for transplant recipients contemplating pregnancy
\n\t\t\t\t
\n\t\t\t\t\t
3.7.1. Management of preeclampsia and chronic hypertension
\n\t\t\t\t\t
Preeclampsia is the most common complication, affecting 30% of pregnancies in renal transplant recipients, especially those with pre-transplant hypertension. Women with mild to moderate hypertension should be watched closely, warned about signs of early superimposed preeclampsia.
\n\t\t\t\t\t
In transplant recipients, changes in urinary protein excretion, plasma uric acid, platelet count, or liver function tests seem to be less useful as markers of preeclampsia than in the normal population. Blood pressure, renal function, proteinuria and weight should be monitored every 2-4 weeks, with more attention during the third trimester. Anti-hypertensive agents should be changed to those tolerated during pregnancy.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.7.2. Antihypertensive drugs used in pregnancy
\n\t\t\t\t\t
Safety and efficacy of Alpha Methyldopa are supported in several randomized trials and in 7.5 years follow up study of children born to treated mothers.
\n\t\t\t\t\t
Beta Blockers; especially Atenolol and Metoprolol, appear to be safe and efficacious in late pregnancy; but fetal growth retardation has been noted when treatment was started in early or midgestation (Lindheimer MD.Davison JM 2001).
\n\t\t\t\t\t
Hydralazine is safe and used frequently as adjunctive therapy with α methyldopa and β blockers.
\n\t\t\t\t\t
Calcium Channel Blockers such as Nifedipine, Nicardipine and Verapamile have been used in severe hypertension. They do not appear to be associated with any increase in congenital anomalies when used in the first trimester.
\n\t\t\t\t\t
Calcium channel blockers may potentiate the hypotensive effects and neuromuscular blockade of magnesium and the interaction should be kept in mind when the drugs are used in women with a possibility of developing preeclampsia (Dynder 1988).
\n\t\t\t\t\t
Labetalol appears to be as effective as methyldopa, but there is little follow up information on children born to mothers treated with this drug.
\n\t\t\t\t\t
The second and third trimester exposure to ACE inhibitors and AT1 antagonists may be associated with serious adverse fetal effects. Most of these problems have been disturbances of fetal and neonatal renal function, such as oligohydramnios, neonatal anuria, renal failure and death (Pryde 1993). The fetal outcome is generally good in women who present in early pregnancy while taking an ACE inhibitor if the drug is stopped.
\n\t\t\t\t\t
Continued administration of an ACE inhibitor during pregnancy is contraindicated (Shotan 1994).
\n\t\t\t\t\t
The use of thiazide diuretics has been approved in women with chronic hypertension if prescribed before gestation; however, the recommendation is against their use in preeclamptic women, who often manifest decreased intravascular volumes and poor placental perfusion.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.7.3. Management of infection
\n\t\t\t\t\t
Pregnancy is associated with suppression of the adaptive immune system. There is evidence that pregnant women in general are more susceptible to infection. Infection also is an important consideration in any patient receiving immunosuppressive drugs, including transplant patients.
\n\t\t\t\t\t
\n\t\t\t\t\t\t
3.7.3.1. Bacterial
\n\t\t\t\t\t\t
Urinary tract infections are the most common bacterial infections and occur in up to 40% of pregnant transplant recipients, and are particularly common in patients who develop end-stage renal disease due to pyelonephritis. These women should have monthly screening urine cultures (Armenti, Constantinescu et al. 2008), if asymptomatic bacteriuria is present; the patient should be treated for 2 weeks and may be treated with suppressive doses of antibiotics for the rest of the pregnancy (Lessan-Pezeshki M 2002). If there is a need for invasive procedures such as fetal monitoring with scalp electrodes or intrauterine pressure monitoring, prophylactic antibiotics are recommended. Aseptic technique should be used for even minor surgery and steroid therapy augmented.
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
3.7.3.2. Viral
\n\t\t\t\t\t\t
Cytomegalovirus (CMV) remains the most frequent cause of viral infection post transplantation, however if the patient waits the recommended time after transplantation to become pregnant, she has passed the peak time of risk for CMV infection.
\n\t\t\t\t\t\t
Infection in the fetus can be diagnosed by culturing the amniotic fluid. Titers of anti-CMV IgG and IgM during pregnancy are recommended, Ganciclovir has caused birth defects in animals when administered at twice human dose (Hou S and 1999). Herpes Simplex Virus (HSV) infection before 20 weeks gestation is associated with an increased rate of abortion. A positive HSV cervical culture at term is an indication for cesarean section. This can minimize the risk for neonatal herpes. Acyclovir can be safely used in pregnancy (Andrew 1992).
\n\t\t\t\t\t\t
Continuous exposure to CsA in utero seems to impair T-, B- and NK-cell development and function in neonates. This effect is prolonged throughout the first year of life. In addition, low levels of serum immunoglobulins occur at the same time. This leads to suggest a delayed administration of classical vaccinations (after the first 6 months of life) in view of the potential risks of both sub-optimal immunologic responses, and adverse events after the administration of live, attenuated vaccines in infants born from young female organ transplant recipients (Schen 2002).
\n\t\t\t\t\t\t
An infant born to an HBSAg – positive mother should be given hepatitis B immunoglobulin within 12 hours of birth and HBV vaccine at another site within 48 hours followed by a booster injection at 1 and 6 month.
\n\t\t\t\t\t\t
The combination of immunoglobulin and vaccine offers protection for more than 90% of infants.
\n\t\t\t\t\t\t
Vertical transmission is believed to be low (<7%) with hepatitis C unless the patient is also infected with the human immunodeficiency virus (Lessan-Pezeshki M 2002).
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.7.4. Labor and delivery
\n\t\t\t\t\t
The incidence of pre-term delivery is 50%, because of presence of preeclampsia, renal function deterioration, fetal distress, premature rupture of membrane and premature labor. Intrauterine uterine growth retardation showing small-for-age babies is present in 20% of pregnancies. In general, successful fetal outcome is related to better renal function at conception. Despite immunosuppressive therapy there is no increase of fetal abnormalities.
\n\t\t\t\t\t
A transplanted kidney rarely obstructs labor, vaginal delivery is recommended in most transplant recipient women. Cesarean section should be performed only for standard obstetric reasons. Delivery should occur in a specialized centre. Care must be taken to avoid fluid overload and infection. At the time of delivery, instrumentation should be minimized. Patients with renal insufficiency may be particularly at risk for water retention secondary to oxytocin (Lessan-Pezeshki M 2002).
\n\t\t\t\t\t
In the perinatal period, the steroid dose should be augmented to cover the stress of labor and to prevent postpartum rejection. Hydrocortisone, 100 mg every 6 hours, should be given during labor and delivery. In the puerperium, renal function, proteinuria, blood pressure, cyclosporine/tacrolimus blood levels and fluid balance should be closely monitored.
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
3.7.5. Breastfeeding
\n\t\t\t\t\t
Breastfeeding is discouraged for patients taking any immunosuppressive drugs. Cyclosporine measurement in maternal blood and breast milk revealed a mean breast milk/ maternal blood level ratio of 84% (Munoz-Flores- thiagarajan and 2001).
\n\t\t\t\t\t
Azathioprine is also appears in breast milk, these levels can be toxic to a newborn, and nursing is not recommended. Similar recommendations exist for tacrolimus or any other immunosuppressive agents.
\n\t\t\t\t\t
In summary, Because the outcome of pregnancy in transplantation are so different than those in chronic dialysis, it is advisable to treat end-stage renal disease patients with transplantation and wait until renal function has been stable for 1 to 2 years before undertaking a planned pregnancy. Such planned pregnancies offer the mother and fetus the best chance of favorable outcome. Before any woman with a renal transplant embarks on a pregnancy, she should be counseled by an obstetrician and transplant physician. Pregnancy appears to have no significant effect on graft function or survival; however, an important concern is that a mother may not survive to bring up the child that she bears. (Davison JM 1987)
\n\t\t\t\t
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.8. Contraception for transplant patients:
\n\t\t\t\t
Most female transplant recipients are unaware that transplantation has reversed the relative infertility associated with end-stage renal disease. The incidence of unwanted pregnancy among female kidney transplant recipients is significantly higher than general population. An unplanned pregnancy puts this special group at higher risk; either an induced abortion or continuing the pregnancy without a preconceptional evaluation could be harmful (\n\t\t\t\t\t\tLessan-Pezeshki and 2004\n\t\t\t\t\t). Outcomes for unwanted pregnancies are inferior to outcomes for planned pregnancies, so it is strongly advised that every sexually active transplant recipient attend a family-planning counseling session. Contraceptive counseling should be provided before transplantation surgery, because ovulatory cycles may begin within 1 to 2 months after transplantation in women with grafts that are functioning well. Women who do not desire pregnancy should be protected by an effective method of contraception. Surgical contraception (sterilization) should be considered for those who have completed their family. Tubal ligation can be performed at the time of transplantation surgery. Vasectomy is also an effective form of permanent contraception with little morbidity. The risk for infection may be increased with the use of an intrauterine device in immuno-compromised patients, and their efficacy decrease because of anti-inflammatory effects of immunosuppressive agents (Zerner J, Doil KL et al. 1981). New devices containing levonorgestrel are more effective than previous copper containing devices, with fewer side effects (Fong and Singh 1999).
\n\t\t\t\t
Depot medroxyprogesterone acetate injection at three months interval is another effective method of contraception for these patients but return of fertility after discontinuation is not fast and loss of bone mineral density is a concern with its long-term use.
\n\t\t\t\t
Although low dose estrogen progesterone oral contraceptive preparations are not contraindicated for transplant patients, but they should be used with caution because they may cause or aggravate hypertension or precipitate thromboembolism, especially in the context of cyclosporine immunosuppression. Calcineurin inhibitors levels should also be monitored soon after the contraceptive is started. Because of unfounded fear of using contraceptive pills, a significant number of kidney transplant recipients use less effective methods such as coitus interruptus. In our study on unwanted pregnancy we found that 92% of women with unwanted pregnancies were using coitus interruptus as the only method of contraception (Ghazizadeh 2005). Progestin-only pill is an option for women who have contraindication to use estrogen but their failure rate is higher than combined oral contraceptive pills. Barrier contraceptives such as male condom are the safest modality but depend on user compliance for efficacy. It provides some protection against sexually transmitted diseases. Patients should know about emergency contraception in case of a broken condom. Two tablets of 0.75 mg of Levonorgestrel pills are administered within 72 hours of unprotected intercourse. Considering the above mentioned issues, unplanned pregnancy should be avoided by proper use of effective contraception.
\n\t\t\t
\n\t\t
\n\t\t
\n\t\t\t
4. Conclusion
\n\t\t\t
Chronic kidney disease affects reproductive and sexual functions in both sexes. Although adequate dialysis will improve this dysfunction to some extent, but successful kidney transplantation has a better impact on fertility and reproductive functions.
\n\t\t\t
Reproductive success is a common, expected outcome for male and female recipients of kidney transplant. One of the most impressive aspects of successful renal transplantation in the young person is the ability of the male patient to father a child and the female patient to give birth to a healthy baby. There are, however, important maternal and fetal complications that need to be considered to provide optimal care to the mother and her infant.
\n\t\t
\n\t\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/17956.pdf",chapterXML:"https://mts.intechopen.com/source/xml/17956.xml",downloadPdfUrl:"/chapter/pdf-download/17956",previewPdfUrl:"/chapter/pdf-preview/17956",totalDownloads:14292,totalViews:935,totalCrossrefCites:1,totalDimensionsCites:1,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:59,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"October 15th 2010",dateReviewed:"April 20th 2011",datePrePublished:null,datePublished:"August 17th 2011",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/17956",risUrl:"/chapter/ris/17956",book:{id:"442",slug:"after-the-kidney-transplant-the-patients-and-their-allograft"},signatures:"Mahboob Lessan-Pezeshki and Shirin Ghazizadeh",authors:[{id:"26564",title:"Prof.",name:"Mahboob",middleName:null,surname:"Lessan Pezeshki",fullName:"Mahboob Lessan Pezeshki",slug:"mahboob-lessan-pezeshki",email:"lessanpezeshki@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"26571",title:"Prof.",name:"Shirin",middleName:null,surname:"Ghazizadeh",fullName:"Shirin Ghazizadeh",slug:"shirin-ghazizadeh",email:"shirin_ghazizadeh@yahoo.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Male reproduction",level:"1"},{id:"sec_2_2",title:"2.1. Physiology of reproduction in men",level:"2"},{id:"sec_3_2",title:"2.2. Male reproduction in end stage renal disease ",level:"2"},{id:"sec_3_3",title:"2.2.1. Gonadal function",level:"3"},{id:"sec_4_3",title:"2.2.2. Pituitary function",level:"3"},{id:"sec_5_3",title:"2.2.3. Hyperprolactinemia",level:"3"},{id:"sec_6_3",title:"2.2.4. Gynecomastia",level:"3"},{id:"sec_8_2",title:"2.3. Erectile dysfunction in end stage renal disease: ",level:"2"},{id:"sec_8_3",title:"2.3.1. Management",level:"3"},{id:"sec_10_2",title:"2.4. Renal transplantation",level:"2"},{id:"sec_10_3",title:"2.4.1. Sexual functions in renal transplant patients",level:"3"},{id:"sec_11_3",title:"2.4.2. Management of erectile dysfunction in transplant patients",level:"3"},{id:"sec_14",title:"3. Female reproduction",level:"1"},{id:"sec_14_2",title:"3.1. Menstrual cycle",level:"2"},{id:"sec_15_2",title:"3.2. Menstrual cycle irregularities in end stage renal disease",level:"2"},{id:"sec_16_2",title:"3.3. Sexual dysfunction in uremic women",level:"2"},{id:"sec_17_2",title:"3.4. Pregnancy in end stage renal disease",level:"2"},{id:"sec_17_3",title:"3.4.1. Management",level:"3"},{id:"sec_19_2",title:"3.5. Pregnancy in renal transplantation",level:"2"},{id:"sec_19_3",title:"3.5.1. Effect of pregnancy on graft function",level:"3"},{id:"sec_21_2",title:"3.6. Immunosuppressive drugs in pregnancy",level:"2"},{id:"sec_21_3",title:"3.6.1. Glucocorticoids",level:"3"},{id:"sec_22_3",title:"3.6.2. Azathioprine",level:"3"},{id:"sec_23_3",title:"3.6.3. Cyclosporine",level:"3"},{id:"sec_24_3",title:"3.6.4. Tacrolimus",level:"3"},{id:"sec_25_3",title:"3.6.5. Mycophenolate Mofetil (MMF)",level:"3"},{id:"sec_26_3",title:"3.6.6. Sirolimus",level:"3"},{id:"sec_27_3",title:"3.6.7. OKT3 and polyclonal antibodies",level:"3"},{id:"sec_28_3",title:"3.6.8. Intravenous Immune Globulins (IVIG)",level:"3"},{id:"sec_29_3",title:"3.6.9. Leflunomide",level:"3"},{id:"sec_31_2",title:"3.7. Management of pregnancy in kidney transplant patient's guidelines:",level:"2"},{id:"sec_31_3",title:"3.7.1. Management of preeclampsia and chronic hypertension",level:"3"},{id:"sec_32_3",title:"3.7.2. Antihypertensive drugs used in pregnancy",level:"3"},{id:"sec_33_3",title:"3.7.3. Management of infection",level:"3"},{id:"sec_33_4",title:"3.7.3.1. Bacterial",level:"4"},{id:"sec_34_4",title:"3.7.3.2. Viral",level:"4"},{id:"sec_36_3",title:"3.7.4. Labor and delivery",level:"3"},{id:"sec_37_3",title:"3.7.5. Breastfeeding",level:"3"},{id:"sec_39_2",title:"3.8. Contraception for transplant patients:",level:"2"},{id:"sec_41",title:"4. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDelano\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1989 "Improvements in quality of life following treatment with r-HuEPO in anemic hemodialysis patients." Am J Kidney Dis(14 EOF\n\t\t\t\t\t8 EOF ): 14.\n\t\t\t'},{id:"B2",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDiemont\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVruggink\n\t\t\t\t\t\t\tP. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMeuleman\n\t\t\t\t\t\t\tE. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2000 "Sexual dysfunction after renal replacement therapy." Am J Kidney Dis 35: 845 EOF\n\t\t\t\t\t51 EOF .\n\t\t\t'},{id:"B3",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFinkel\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPhillips\n\t\t\t\t\t\t\tJ. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSnyder\n\t\t\t\t\t\t\tP. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1985 "Stimulation of spermatogenesis by gonadotropins in men with hypogonadotropic hypogonadism." N Engl J Med(313): 651 EOF\n\t\t\t\t\t5 EOF 1.\n\t\t\t'},{id:"B4",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGrossman\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSwan\n\t\t\t\t\t\t\tS. K.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMuirhead\n\t\t\t\t\t\t\tG. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2004 "The pharmacokinetics and hemodynamics of sildenafil citrate in male hemodialysis patients." Kidney Int(66): 367 EOF\n\t\t\t\t\t374 EOF .\n\t\t\t'},{id:"B5",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHockel\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKaufmann\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1986 "Placental transfer of class G immunoglobulins treated with B-propiolactone ( P-PL) for intravenous application a case report." J Perinat Med 14: 205.\n\t\t\t'},{id:"B6",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHoldsworth\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAtkins\n\t\t\t\t\t\t\tR. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Kretser\n\t\t\t\t\t\t\tD. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1977 "The pituitary-testicular axis in men with chronic renal failure." N Engl J Med (296 ): 1245 EOF\n\t\t\t\t\t9 EOF .\n\t\t\t'},{id:"B7",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHoldsworth\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Kretser\n\t\t\t\t\t\t\tD. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAtkins\n\t\t\t\t\t\t\tR. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1978 " A comparison of hemodialysis and transplantation in reversing the uremic disturbance of male reproductive function." Clin Nephrol(10): 146 EOF\n\t\t\t\t\t50 EOF .\n\t\t\t'},{id:"B8",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHolley\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchmidt\n\t\t\t\t\t\t\tR. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBender\n\t\t\t\t\t\t\tF. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1997 "Gynecologic and reproductive issues in women on dialysis." Am J Kidney Dis 29: 685 EOF\n\t\t\t\t\t90 EOF .\n\t\t\t'},{id:"B9",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIfudu\n\t\t\t\t\t\t\tO.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1998 "Care of patients undergoing hemodialysis." N Engl J Med(339): 1054 EOF\n\t\t\t\t\t62 EOF .\n\t\t\t'},{id:"B10",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLevitan\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMoser\n\t\t\t\t\t\t\tS. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGoldstein\n\t\t\t\t\t\t\tD. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tet\n\t\t\t\t\t\t\tal..\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1984 "Disturbances in the hypothalamic-pituitary-gonadal axis in male patients with acute renal failure." Am J Nephrol (4): 99.\n\t\t\t'},{id:"B11",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLim\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVS\n\t\t\t\t\t\t\tFang\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1976 "Restoration of plasma testosterone levels in uremic men with clomiphene citrate." J Clin Endocrinol Metab(43): 1370 EOF\n\t\t\t\t\t7 EOF 0.\n\t\t\t'},{id:"B12",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRosas\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJoffe\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFranklin\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2003 "Association of decreased quality of life and erectile dysfunction in hemodialysis patients." Kidney Int(64): 232 EOF\n\t\t\t\t\t238 EOF .\n\t\t\t'},{id:"B13",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSawin\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLongcope\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchmitt\n\t\t\t\t\t\t\tG. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRyan\n\t\t\t\t\t\t\tR. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1973 "Blood levels of gonadotropins and gonadal hormones in gynecomastia associated with chronic hemodialysis.." J Clin Endocrinol Metab 36: 988.\n\t\t\t'},{id:"B14",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSievertsen\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVS\n\t\t\t\t\t\t\tLim\n\t\t\t\t\t\t\tNakawatase. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFrohman\n\t\t\t\t\t\t\tL. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1980 "Metabolic clearance and secretion rates of human prolactin in normal subjects and patients with chronic renal failure.." J Clin Endocrinol Metab 50: 846.\n\t\t\t'},{id:"B15",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTurk\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKaralezli\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTonbul\n\t\t\t\t\t\t\tH. Z.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2001 "Erectile dysfunction and the effects of sildenafil treatment in patients on haemodialysis and continuous ambulatory peritoneal dialysis." Nephrol Dial Transplant(16): 1818 EOF\n\t\t\t\t\t22 EOF .\n\t\t\t'},{id:"B16",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWolf\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHan\n\t\t\t\t\t\t\tD. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZiyadeh\n\t\t\t\t\t\t\tF. N.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002 "Leptin and renal disease." Am J Kidney Dis 39: 1 EOF\n\t\t\t\t\t11 EOF .\n\t\t\t'},{id:"B17",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAnderka\n\t\t\t\t\t\t\tM. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLin\n\t\t\t\t\t\t\tA. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2009 "Reviewing the evidence for mycophenolate mofetil as a new teratogen: case report and review of the literature." Am J Med Genet A 149A(6): 1241 EOF\n\t\t\t\t\t1248 EOF -8.\n\t\t\t'},{id:"B18",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAndrew\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYankaskas\n\t\t\t\t\t\t\tB. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCordero\n\t\t\t\t\t\t\tJ. F.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchoeffler\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHampp\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1992 "Acylovir in pregnancy registry: six years experience." Obstet Gynecol(79): 7-13.\n\t\t\t'},{id:"B19",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tArmenti\n\t\t\t\t\t\t\tV. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tConstantinescu\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2008 "Pregnancy after transplantation." Transplant Rev (Orlando) 22\n\t\t\t\t\t4\n\t\t\t\t\t223\n\t\t\t\t\t40 .\n\t\t\t'},{id:"B20",body:'\n\t\t\t\t\n\t\t\t\t\tArmentiVT, Radomski JS, et al.\n\t\t\t\t\t2000 "Report from the National Transplantation Pregnancy Registry(NTPR) outcome of pregnancy after transplantation." Clin Transpl 123\n\t\t\t\t\t34 .\n\t\t\t'},{id:"B21",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBailie\n\t\t\t\t\t\t\tG. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tElder\n\t\t\t\t\t\t\tS. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2007 "Sexual dysfunction in dialysis patients treated with antihypertensive or antidepressive medications: results from the DOPPS." Nephrol Dial Transplant 22\n\t\t\t\t\t4\n\t\t\t\t\t1163\n\t\t\t\t\t70 .\n\t\t\t'},{id:"B22",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBakimer\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGuilburd\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZurgil\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchoenfeld\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1993 "The effect of intravenous gamma globulin on the induction of experimental antiphospholipid syndrome.." Clin Immunol Immunopathol 69: 97.\n\t\t\t'},{id:"B23",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBar\n\t\t\t\t\t\t\tOz. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHackman\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEinarson\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKoren\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2001 (2001 ). " Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis." Transplantation 71\n\t\t\t\t\t8\n\t\t\t\t\t1051\n\t\t\t\t\t5 .\n\t\t\t'},{id:"B24",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBeitins\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBayard\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAnces\n\t\t\t\t\t\t\tI. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1972 "The transplacental passage of prednisone and prednisolone in pregnancy near term." J Pediatr (81): 936 EOF\n\t\t\t\t\t45 EOF .\n\t\t\t'},{id:"B25",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBennett\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCarpenter\n\t\t\t\t\t\t\tA. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBarada\n\t\t\t\t\t\t\tJ. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1991 "An improved vasoactive drug combination for a pharmacological erection program.." J Urol 146\n\t\t\t\t\t1564 .\n\t\t\t'},{id:"B26",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBerek\n\t\t\t\t\t\t\tJ. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002 Novak’s Gynecology, Lippincott Williams & Wilkins.\n\t\t\t'},{id:"B27",body:'\n\t\t\t\t\n\t\t\t\t\tBiller BM; Molitch ME; Vance ML; Cannistraro KB; Davis KR; Simons J1996\n\t\t\t\t\t; Schoenfelder JR; Klibanski A (1996 ). "Treatment of prolactin-secreting macroadenomas with the once-weekly dopamine agonist cabergoline." J Clin Endocrinol Metab 81\n\t\t\t\t\t6\n\t\t\t\t\t2338\n\t\t\t\t\t43 .\n\t\t\t'},{id:"B28",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChao\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2002 "Pregnancy in women who undergo longterm dialysis." Am J Obstet Gynecol 187\n\t\t\t\t\t152\n\t\t\t\t\t156 .\n\t\t\t'},{id:"B29",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCohen\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGalbraith\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2001 "General health management and long-term care of the renal transplant recipient." Am J Kidney Dis 38(6 Suppl 6): S10\n\t\t\t\t\t24 .\n\t\t\t'},{id:"B30",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCowden\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRatcliff\n\t\t\t\t\t\t\tW. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRatcliff\n\t\t\t\t\t\t\tJ. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1981 "Hypothalamic-Pituitary function in uremia." Acta Endocrinol 98: 488.\n\t\t\t'},{id:"B31",body:'\n\t\t\t\t\n\t\t\t\t\tDanovitch GM\n\t\t\t\t\t2005 Handbook of Kidney Transplantation, Lippincott Williams&Wilkins.\n\t\t\t'},{id:"B32",body:'\n\t\t\t\t\n\t\t\t\t\tDavison JM\n\t\t\t\t\t1987 "Renal transplantation and pregnancy.." Am J Kidney Dis 9: 374.\n\t\t\t'},{id:"B33",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDe Celis\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPedron-Nuevo\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1999 "Male fertility of kidney transplant patients with one to ten years of evolution using a conventional immunosuppressive regimen." Arch Androl 42\n\t\t\t\t\t1\n\t\t\t\t\t9\n\t\t\t\t\t20 .\n\t\t\t'},{id:"B34",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Vries\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGooren\n\t\t\t\t\t\t\tL. J. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOe\n\t\t\t\t\t\t\tP. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1984 "Hemodialysis and testicular function." Int J Androl(7): 97.\n\t\t\t'},{id:"B35",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDenton\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaylis\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007 "Physiological and molecular mechanisms governing sexual dimorphism of kidney, cardiac, and vascular function." Am J Physiol Regul Integr Comp Physiol 292(2): R697\n\t\t\t\t\t9 .\n\t\t\t'},{id:"B36",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDiemont\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVruggink\n\t\t\t\t\t\t\tP. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMeuleman\n\t\t\t\t\t\t\tE. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2000 "Sexual dysfunction after renal replacement therapy." Am J Kidney Dis (35): 845 EOF\n\t\t\t\t\t51 EOF .\n\t\t\t'},{id:"B37",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDynder\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMS\n\t\t\t\t\t\t\tCardwell\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1988 "Neuromuscular blockade with magnesium sulfate and nifedipine." Am J Obstet Gynecol(161 ): 35-36.\n\t\t\t'},{id:"B38",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEid\n\t\t\t\t\t\t\tM. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAbdel-Hamid\n\t\t\t\t\t\t\tI. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1996 "Assessment of sperm motion characteristics in infertile renal transplant recipients using computerized analysis." Int J Androl 19\n\t\t\t\t\t6\n\t\t\t\t\t338\n\t\t\t\t\t44 .\n\t\t\t'},{id:"B39",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEisenberg\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tArmenti\n\t\t\t\t\t\t\tV. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMc Grovy\n\t\t\t\t\t\t\tC. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1997 "National transplantation pregnancy registry(NTPR) : Use of muromonab-CD3(OKT3) during pregnancy in female transplant recipients." Am Soc Transplant phys( 20): 108.\n\t\t\t'},{id:"B40",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEsteban la\n\t\t\t\t\t\t\tRosa. R. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBravo\n\t\t\t\t\t\t\tJ. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSoto\n\t\t\t\t\t\t\tet.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tal\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2003 "Influence of age, sex, and hepatitis C virus infection on peripheral blood lymphocyte subsets in stable kidney transplantation." Transplant Proc 35\n\t\t\t\t\t8\n\t\t\t\t\t2905\n\t\t\t\t\t7 .\n\t\t\t'},{id:"B41",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFong\n\t\t\t\t\t\t\tY. F.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSingh\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1999 "Effect of the levonorgestrel-releasing intrauterine system on uterine myomas in a renal transplant patient." Contraception 60\n\t\t\t\t\t1\n\t\t\t\t\t51\n\t\t\t\t\t3 .\n\t\t\t'},{id:"B42",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGhazizadeh\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLessan-Pezeshki\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKhatami\n\t\t\t\t\t\t\tM. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMahdavi\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005 "Unwanted Pregnancy in Kidney Transplant Recipients in Iran." Transplantation Proceedings 37\n\t\t\t\t\t7\n\t\t\t\t\t3085\n\t\t\t\t\t3086 .\n\t\t\t'},{id:"B43",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHagen\n\t\t\t\t\t\t\tC. O. K.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAS\n\t\t\t\t\t\t\tMc Neilly\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1976 "Prolactin and the pituitary gonadal axisin male uremic patients on regular dialysis.." Acta Endocrinol (Copenh)(82): 29.\n\t\t\t'},{id:"B44",body:'\n\t\t\t\t\n\t\t\t\t\tHenrich WL\n\t\t\t\t\t2004 Principles and Practice of Dialysis, Lippincott Williams&Wilkins.\n\t\t\t'},{id:"B45",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHigham\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tO’Brien\n\t\t\t\t\t\t\tP. M. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShaw\n\t\t\t\t\t\t\tR. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1990 "Assessment of menstrual blood loss using pictorial chart." Br J Obstet Gynaecol 97: 734 EOF\n\t\t\t\t\t9 EOF .\n\t\t\t'},{id:"B46",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHou\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1987 " Pregnancy in women requiring dialysis for renal failure." Am J Kidney Dis 9 368 EOF\n\t\t\t\t\t73 EOF .\n\t\t\t'},{id:"B47",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHou\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1999 "Pregnancy in chronic renal insufficiency and end stage renal disease.." Am J Kidney Dis (33): 235.\n\t\t\t'},{id:"B48",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIssac\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1978 " Effect of parathyroid hormone on plasma prolactin men." (47): 18.\n\t\t\t'},{id:"B49",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJuenemann\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLue\n\t\t\t\t\t\t\tT. F.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLuo\n\t\t\t\t\t\t\tJ. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBenowitz\n\t\t\t\t\t\t\tN. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAbozeid\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTanagho\n\t\t\t\t\t\t\tE. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1987 "The effect of cigarette smoking on penile erection." J Urol 138\n\t\t\t\t\t438 .\n\t\t\t'},{id:"B50",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJungers\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChauveau\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1997 "Pregnancy in renal disease" Kidney Int 52\n\t\t\t\t\t871\n\t\t\t\t\t885 .\n\t\t\t'},{id:"B51",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKaczmarek\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGroetzner\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAdamidis\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLandwehr\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2004 "Sirolimus impairs gonadal function in heart transplant recipients.." Am J of Transplantation 4: 1084.\n\t\t\t'},{id:"B52",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKaniz\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHarabacz\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCowirick\n\t\t\t\t\t\t\tI. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2000 "Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus.." Transplantation proceeding(70): 1718.\n\t\t\t'},{id:"B53",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLasaponara\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPasquale\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2009 "[Penile prosthesis implantation in kidney-transplanted patients.]." Urologia 76\n\t\t\t\t\t2\n\t\t\t\t\t95\n\t\t\t\t\t97 .\n\t\t\t'},{id:"B54",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLe Roith\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDanovitz\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTrestian\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpitz\n\t\t\t\t\t\t\tI. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1980 "Dissociation of pituitary glycoprotein response to releasing hormones in chronic renal failure." Acta Endocrinol (Copenh)(93): 277 EOF\n\t\t\t\t\t82 EOF .\n\t\t\t'},{id:"B55",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLessan-Pezeshki\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002 "Pregnancy After Renal Transplantation, Points to Consider " Nephrol Dial Transplant 17\n\t\t\t\t\t703\n\t\t\t\t\t707 .\n\t\t\t'},{id:"B56",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLessan-Pezeshki\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGhazizadeh\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2004 "Fertility and contraceptive issues after kidney transplantation in women." Transplant Proc 36\n\t\t\t\t\t5\n\t\t\t\t\t1405\n\t\t\t\t\t6 .\n\t\t\t'},{id:"B57",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLessan-Pezeshki\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGhazizadeh\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKhatami\n\t\t\t\t\t\t\tM. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMahdavi\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRazeghi\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeifi\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAhmadi\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaziar\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2004 "Fertility and contraceptive issues after kidney transplantation in women " Transplantation proceeding (36): 1405 EOF\n\t\t\t\t\t6 EOF .\n\t\t\t'},{id:"B58",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLim\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKathpalia\n\t\t\t\t\t\t\tS. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHenriques\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1978 "Endocrine abnormalities associated with chronic renal failure." Med Clin North Am 62:. 1341 EOF\n\t\t\t\t\t61 EOF .\n\t\t\t'},{id:"B59",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMd\n\t\t\t\t\t\t\tLindheimer\n\t\t\t\t\t\t\tK. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1992 "Pregnancy in the renal transplant patients." Am J Kidney Dis (19): 173 EOF\n\t\t\t\t\t6 EOF .\n\t\t\t'},{id:"B60",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLindheimer\n\t\t\t\t\t\t\tM. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavison\n\t\t\t\t\t\t\tJ. M. K. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2001 "The kidney and hypertension in pregnancy: twenty exciting years." Semin Nephrol 21\n\t\t\t\t\t2\n\t\t\t\t\t173\n\t\t\t\t\t189 .\n\t\t\t'},{id:"B61",body:'\n\t\t\t\t\n\t\t\t\t\tLue T F\n\t\t\t\t\t2000 "Erectile dysfunction." The New England Journal of Medicine 342(24): 1802 EOF\n\t\t\t\t\t13 EOF , 12.\n\t\t\t'},{id:"B62",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMahanty\n\t\t\t\t\t\t\tH. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCherikh\n\t\t\t\t\t\t\tW. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2001 "Influence of pretransplant pregnancy on survival of renal allografts from living donors." Transplantation 72\n\t\t\t\t\t2\n\t\t\t\t\t228\n\t\t\t\t\t32 .\n\t\t\t'},{id:"B63",body:'\n\t\t\t\t\n\t\t\t\t\tMatthew RW\n\t\t\t\t\t2005 Medical Management of Kidney transplantation, Lippincott Williams & Wilkins.\n\t\t\t'},{id:"B64",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMiller\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMS\n\t\t\t\t\t\t\tGold\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1988 "The human sexual response and alcohol and drugs." J Subst Abuse Treat 5\n\t\t\t\t\t171\n\t\t\t\t\t7 .\n\t\t\t'},{id:"B65",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMirone\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLongo\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2009 "Renal transplantation does not improve erectile function in hemodialysed patients." Eur Urol 56\n\t\t\t\t\t6\n\t\t\t\t\t1047\n\t\t\t\t\t53 .\n\t\t\t'},{id:"B66",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMuller\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMunder\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2009 "Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms?" Trends Immunol 30\n\t\t\t\t\t11\n\t\t\t\t\t522\n\t\t\t\t\t30 .\n\t\t\t'},{id:"B67",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMunoz-Flores-thiagarajan\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEasterling\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavis\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBond\n\t\t\t\t\t\t\tE. F.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2001 " Breast-feeding by a cyclosporine- treated mother." Obstet Gynecol(97): 816-8.\n\t\t\t'},{id:"B68",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMurirhead\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSabharwal\n\t\t\t\t\t\t\tA. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMJ\n\t\t\t\t\t\t\treider\n\t\t\t\t\t\t\tet.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tal\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1992 "The outcome of pregnancy following renal transplantation- the experience of a single center." Transplantation proceeding(54): 429.\n\t\t\t'},{id:"B69",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMurray\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tReid\n\t\t\t\t\t\t\tD. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHarrison\n\t\t\t\t\t\t\tJ. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1963 "Successful pregnancies after human renal transplantation." N Engl J Med: 269:346.\n\t\t\t'},{id:"B70",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNevins\n\t\t\t\t\t\t\tT. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDunn\n\t\t\t\t\t\t\tD. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1992 "Use of ganciclovir for cytomegalovirus infection." J Am Soc Nephrol 2(12 Suppl): S270\n\t\t\t\t\t3 .\n\t\t\t'},{id:"B71",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOlshan\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMattison\n\t\t\t\t\t\t\tD. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZwanenburg\n\t\t\t\t\t\t\tT. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1994 "International Commission for Protection against Environmental Mutagens and Carcinogens. Cyclosporine A: review of genotoxicity and potential for adverse human reproductive and developmental effects. Report of a working group on the genotoxicity of cyclosporine A,." Mutat Res 317\n\t\t\t\t\t163\n\t\t\t\t\t173 .\n\t\t\t'},{id:"B72",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPalmer\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1999 "Sexual dysfunction in uremia." J Am Soc Nephrol (10): 1381.\n\t\t\t'},{id:"B73",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPece\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1979 "Prolactin in chronic renal failure, hemodialysis and transplant patients " Proc Eur Dial Transplant Assoc (16): 700.\n\t\t\t'},{id:"B74",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPhe\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRoupret\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2009 "[Erectile dysfunction and renal chronic insufficiency: etiology and management]." Prog Urol 19\n\t\t\t\t\t1\n\t\t\t\t\t1\n\t\t\t\t\t7 .\n\t\t\t'},{id:"B75",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrice\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGingell\n\t\t\t\t\t\t\tJ. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGepi-Attee\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWareham\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1998 "Sildenafil: Study of a novel oral treatment for erectile dysfunction in diabetic men." Diabet Med 15\n\t\t\t\t\t821\n\t\t\t\t\t5 .\n\t\t\t'},{id:"B76",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tProcci\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGoldstein\n\t\t\t\t\t\t\tD. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAdelstein\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1981 "Sexual dysfunction in the male patient with uremia; a reappraisal." Kidney Int 19: 317.\n\t\t\t'},{id:"B77",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPryde\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSedman\n\t\t\t\t\t\t\tA. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCE\n\t\t\t\t\t\t\tNugent\n\t\t\t\t\t\t\tBarr. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJr \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1993 "Angiotensin converting enzyme inhibitor fetopathy." J Am Soc Nephrol (3 ): 1575.\n\t\t\t'},{id:"B78",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRamirez\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tO`\n\t\t\t\t\t\t\tNeil. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJubiz\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1976 "Thyroid dysfunction in uremia: evidence for thyroid and hypophyseal abnormalities." Am Intern Med 84: 627.\n\t\t\t'},{id:"B79",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRedrow\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCherem\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tElliott\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMangalat\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1988 Mangalat, J, (1988 ). "Dialysis in the management of pregnant patients with renal insufficiency." Medicine 67\n\t\t\t\t\t4\n\t\t\t\t\t199\n\t\t\t\t\t208 .\n\t\t\t'},{id:"B80",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRizzoni\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEhrich\n\t\t\t\t\t\t\tJ. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1992 "Successful pregnancies in women on renal replacement therapy: report from the EDTA Registry." Nephrol Dial Transplant 7\n\t\t\t\t\t4\n\t\t\t\t\t279\n\t\t\t\t\t87 .\n\t\t\t'},{id:"B81",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSafwenberg\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBackman-Bave\n\t\t\t\t\t\t\tU.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1977 "The effect of blood transfusions on cadaver kidney transplants--an analysis of patients transplanted in Uppsala." Scand J Urol Nephrol Suppl(42): 59-61.\n\t\t\t'},{id:"B82",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSalmela\n\t\t\t\t\t\t\tK. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKyllonen\n\t\t\t\t\t\t\tL. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1993 "Impaired renal function after pregnancy in renal transplant recipients." Transplantation 56\n\t\t\t\t\t6\n\t\t\t\t\t1372\n\t\t\t\t\t5 .\n\t\t\t'},{id:"B83",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSarikoski\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeppala\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1973 " Immunosupression during pregnancy: transmission of azathioprine and its metabolites from the mother to the fetus." Am J Obstet Gynecol(115): 1100.\n\t\t\t'},{id:"B84",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchaefer\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStanhope\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1989 "Pulsatile gonadotropin secretion in pubertal children with chronic renal failure." Acta Endocrinol (Copenh) 120\n\t\t\t\t\t1\n\t\t\t\t\t14\n\t\t\t\t\t9 .\n\t\t\t'},{id:"B85",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchen\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStallone\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchena\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tManfredi\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDerosa\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tProcino\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDi Paolo\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002 "Pregnancy in renal transplantation: immunologic evaluation of neonates from mothers with transplanted kidney." Transpl Immunol 9(2-4): 161-4.\n\t\t\t'},{id:"B86",body:'\n\t\t\t\t\n\t\t\t\t\tSchrier RW\n\t\t\t\t\t2001 Diseases of the kidney and urinary tract, Lippincott Williams&Wilkins.\n\t\t\t'},{id:"B87",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSciarra\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2001 Gynecology &Obststrics, Lippincot Williams & Wilkins.\n\t\t\t'},{id:"B88",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeethalakshmi\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDiamond\n\t\t\t\t\t\t\tD. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMalhotra\n\t\t\t\t\t\t\tR. K.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMazanitis\n\t\t\t\t\t\t\tS. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKumar\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMenon\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1988 "Cyclosporine induced testicular dysfunction: a separation of the nephrotoxic component and an assessment of a 60 -day recovery period.." Transplant Proc 20 (Suppl 3): 1005-1010.\n\t\t\t'},{id:"B89",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeethalakshmi\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFlores\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAA\n\t\t\t\t\t\t\tCarboni\n\t\t\t\t\t\t\tBala. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDiamond\n\t\t\t\t\t\t\tD. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMenon\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1990 "Cyclosporine: its effect on testicular function and fertility in the prepubertal rat.." J Androl 11\n\t\t\t\t\t17\n\t\t\t\t\t24 .\n\t\t\t'},{id:"B90",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeethalakshmi\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFlores\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDiamond\n\t\t\t\t\t\t\tD. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMenon\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1990 "Reversal of the toxic effects of cyclosporineA (CsA) on male reproduction and kidney function of rats by simultaneous administration of hCG and FSH." J Urol 144\n\t\t\t\t\t1489\n\t\t\t\t\t149 .\n\t\t\t'},{id:"B91",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeibel\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPoli De\n\t\t\t\t\t\t\tFigueiredo.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCE\n\t\t\t\t\t\t\tTeloken\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMoraes\n\t\t\t\t\t\t\tJ. F.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002 "Efficacy of oral sildenafil in hemodialysis patients with erectile dysfunction." J Am Soc Nephrol (13): 2770.\n\t\t\t'},{id:"B92",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSgro\n\t\t\t\t\t\t\tM. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBarozzino\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2002 "Pregnancy outcome post renal transplantation." Teratology 65\n\t\t\t\t\t1\n\t\t\t\t\t5\n\t\t\t\t\t9 .\n\t\t\t'},{id:"B93",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShotan\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWiderhorn\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHurst\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tElkayam\n\t\t\t\t\t\t\tU.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1994 "Risks of angiotensin converting enzyme inhibition during pregnancy: experimental and clinical evidence, potential mechanisms and recommendations for use." Am J Med(96): 451.\n\t\t\t'},{id:"B94",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSteele\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWuerth\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFinkelstein\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1996 "Sexual experience of the chronic peritoneal dialysis patient." J Am Soc Nephrol(7): 1165.\n\t\t\t'},{id:"B95",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStewart-Bentley\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGans\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHorton\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1974 "Regulation of gonadal function in uremia." Metabolism (23): 1065.\n\t\t\t'},{id:"B96",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSturgiss\n\t\t\t\t\t\t\tS. N.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavison\n\t\t\t\t\t\t\tJ. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1995 "Effect of pregnancy on the long-term function of renal allografts: an update." Am J Kidney Dis 26\n\t\t\t\t\t1\n\t\t\t\t\t54\n\t\t\t\t\t6 .\n\t\t\t'},{id:"B97",body:'\n\t\t\t\t\n\t\t\t\t\tThurm\n\t\t\t\t\t1976 (1976 ). " Effect of chronic renal disease on sexual functioning." Med Asp Human Sex 10: 81.\n\t\t\t'},{id:"B98",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tToorians\n\t\t\t\t\t\t\tA. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJanssen\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1997 "Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response." Nephrol Dial Transplant 12\n\t\t\t\t\t12\n\t\t\t\t\t2654\n\t\t\t\t\t63 .\n\t\t\t'},{id:"B99",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTreloar\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBoynton\n\t\t\t\t\t\t\tR. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBehn\n\t\t\t\t\t\t\tB. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrown\n\t\t\t\t\t\t\tB. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrown\n\t\t\t\t\t\t\tB. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1967 "Variation of the human menstrual cycle through reproductive life." Int J Fertil 12: 77.\n\t\t\t'},{id:"B100",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWang\n\t\t\t\t\t\t\tH. Y.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHuang\n\t\t\t\t\t\t\tY. F.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2009 "Vardenafil for refractory erectile dysfunction: the latest advances." Zhonghua Nan Ke Xue 15\n\t\t\t\t\t11\n\t\t\t\t\t1035\n\t\t\t\t\t8 .\n\t\t\t'},{id:"B101",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYang\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJu\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2008 "Efficacy and safety of vardenafil for kidney transplant recipients with erectile dysfunction." Zhonghua Nan Ke Xue 14\n\t\t\t\t\t10\n\t\t\t\t\t911\n\t\t\t\t\t3 .\n\t\t\t'},{id:"B102",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZerner\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDoil\n\t\t\t\t\t\t\tK. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t1981 "Intrauterine contraceptive device failures in renal transplant patients." J Reprod Med. 26\n\t\t\t\t\t2\n\t\t\t\t\t99\n\t\t\t\t\t102 .\n\t\t\t'},{id:"B103",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZuber\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAnglicheau\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\t2008 "Sirolimus may reduce fertility in male renal transplant recipients." Am J Transplant 8\n\t\t\t\t\t7\n\t\t\t\t\t1471\n\t\t\t\t\t9 .\n\t\t\t'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Mahboob Lessan-Pezeshki",address:"",affiliation:'
Nephrology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Iran
Obstetrics and Gynecology Department, Tehran University of Medical Sciences, Iran
'}],corrections:null},book:{id:"442",type:"book",title:"After the Kidney Transplant",subtitle:"The Patients and Their Allograft",fullTitle:"After the Kidney Transplant - The Patients and Their Allograft",slug:"after-the-kidney-transplant-the-patients-and-their-allograft",publishedDate:"August 17th 2011",bookSignature:"Jorge Ortiz and Jason Andre",coverURL:"https://cdn.intechopen.com/books/images_new/442.jpg",licenceType:"CC BY-NC-SA 3.0",editedByType:"Edited by",isbn:null,printIsbn:"978-953-307-807-6",pdfIsbn:"978-953-51-6447-0",reviewType:"peer-reviewed",numberOfWosCitations:6,isAvailableForWebshopOrdering:!0,editors:[{id:"33534",title:"Prof.",name:"Jorge",middleName:null,surname:"Ortiz",slug:"jorge-ortiz",fullName:"Jorge Ortiz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"34295",title:"Prof.",name:"Jason",middleName:null,surname:"Andre",slug:"jason-andre",fullName:"Jason Andre"},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1163"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"17944",type:"chapter",title:"Infectious Complications in Kidney Transplantation",slug:"infectious-complications-in-kidney-transplantation",totalDownloads:3686,totalCrossrefCites:1,signatures:"Amr El-Husseini and Rashad Hassan",reviewType:"peer-reviewed",authors:[{id:"26231",title:"Prof.",name:"Amr",middleName:null,surname:"El-Husseini",fullName:"Amr El-Husseini",slug:"amr-el-husseini"},{id:"26438",title:"Dr.",name:"Rashad",middleName:"Hassan Rashad",surname:"Hassan",fullName:"Rashad Hassan",slug:"rashad-hassan"}]},{id:"17945",type:"chapter",title:"Handling of Fungal Infections in Patients with Chronic Immunosuppression Post Renal Transplant",slug:"handling-of-fungal-infections-in-patients-with-chronic-immunosuppression-post-renal-transplant",totalDownloads:3093,totalCrossrefCites:0,signatures:"Ewa Swoboda-Kopec, Irina Netsvyetayeva, Magdalena Sikora, Mariusz Jasik and Piotr Fiedor",reviewType:"peer-reviewed",authors:[null]},{id:"17946",type:"chapter",title:"CMV Infection in CMV-Seropositive Kidney Transplant Recipients",slug:"cmv-infection-in-cmv-seropositive-kidney-transplant-recipients",totalDownloads:3489,totalCrossrefCites:0,signatures:"Jong Man Kim and Sung Joo Kim",reviewType:"peer-reviewed",authors:[{id:"26906",title:"Prof.",name:"Sung Joo",middleName:null,surname:"Kim",fullName:"Sung Joo Kim",slug:"sung-joo-kim"},{id:"41717",title:"Prof.",name:"Jong Man",middleName:null,surname:"Kim",fullName:"Jong Man Kim",slug:"jong-man-kim"}]},{id:"17947",type:"chapter",title:"Posttransplant Lymphoproliferative Disorders Following Kidney Transplantation",slug:"posttransplant-lymphoproliferative-disorders-following-kidney-transplantation",totalDownloads:2593,totalCrossrefCites:0,signatures:"Daan Dierickx",reviewType:"peer-reviewed",authors:[{id:"94859",title:"Dr.",name:"Daan",middleName:null,surname:"Dierickx",fullName:"Daan Dierickx",slug:"daan-dierickx"}]},{id:"17948",type:"chapter",title:"Post-Trasplant Lymphoproliferative Disorders (PTLD) in Adult Kidney Trasplantated Patients",slug:"post-trasplant-lymphoproliferative-disorders-ptld-in-adult-kidney-trasplantated-patients",totalDownloads:2756,totalCrossrefCites:0,signatures:"Savina Aversa, Silvia Stragliotto, Fabio Canova, Boso Caterina and Marino Dario",reviewType:"peer-reviewed",authors:[{id:"34968",title:"Prof.",name:"Savina",middleName:null,surname:"Aversa",fullName:"Savina Aversa",slug:"savina-aversa"},{id:"39597",title:"Dr.",name:"Silvia",middleName:null,surname:"Stragliotto",fullName:"Silvia Stragliotto",slug:"silvia-stragliotto"},{id:"39598",title:"Prof.",name:"FABIO",middleName:null,surname:"CANOVA",fullName:"FABIO CANOVA",slug:"fabio-canova"},{id:"39599",title:"Dr.",name:"Caterina",middleName:null,surname:"Boso",fullName:"Caterina Boso",slug:"caterina-boso"},{id:"39600",title:"Dr.",name:"Dario",middleName:null,surname:"Marino",fullName:"Dario Marino",slug:"dario-marino"}]},{id:"17949",type:"chapter",title:"Focal Segmental Glomerulosclerosis (FSGS) Recurrence in Kidney Allograft Recipients",slug:"focal-segmental-glomerulosclerosis-fsgs-recurrence-in-kidney-allograft-recipients",totalDownloads:4326,totalCrossrefCites:0,signatures:"Oktawia Mazanowska and Dorota Kamińska",reviewType:"peer-reviewed",authors:[{id:"42055",title:"Dr",name:"Oktawia",middleName:null,surname:"Mazanowska",fullName:"Oktawia Mazanowska",slug:"oktawia-mazanowska"},{id:"42064",title:"Dr.",name:"Dorota",middleName:null,surname:"Kaminska",fullName:"Dorota Kaminska",slug:"dorota-kaminska"}]},{id:"17950",type:"chapter",title:"Therapeutic Approach to Focal and Segmental Glomerulosclerosis (FSGS) Recurrence in Kidney Transplant Recipients",slug:"therapeutic-approach-to-focal-and-segmental-glomerulosclerosis-fsgs-recurrence-in-kidney-transplant-",totalDownloads:2622,totalCrossrefCites:0,signatures:"Guillaume Canaud, Frank Martinez and Christophe Legendre",reviewType:"peer-reviewed",authors:[{id:"26131",title:"Dr.",name:"Guillaume",middleName:null,surname:"Canaud",fullName:"Guillaume Canaud",slug:"guillaume-canaud"},{id:"38616",title:"Dr.",name:"Frank",middleName:null,surname:"Martinez",fullName:"Frank Martinez",slug:"frank-martinez"},{id:"38617",title:"Prof.",name:"Christophe",middleName:null,surname:"Legendre",fullName:"Christophe Legendre",slug:"christophe-legendre"}]},{id:"17951",type:"chapter",title:"Post-Transplant Glomerulonephritis in Live-Donor Renal Transplant Recipients: Clinical Course and Risk Factors",slug:"post-transplant-glomerulonephritis-in-live-donor-renal-transplant-recipients-clinical-course-and-ris",totalDownloads:2696,totalCrossrefCites:0,signatures:"Ahmed Akl, Hany Adel and Ehab Wafa",reviewType:"peer-reviewed",authors:[{id:"25964",title:"Dr.",name:"Ahmed",middleName:null,surname:"Akl",fullName:"Ahmed Akl",slug:"ahmed-akl"},{id:"42810",title:"Dr.",name:"Hany",middleName:"Adel",surname:"Mansour",fullName:"Hany Mansour",slug:"hany-mansour"},{id:"42811",title:"Prof.",name:"Ehab",middleName:null,surname:"Wafa",fullName:"Ehab Wafa",slug:"ehab-wafa"}]},{id:"17952",type:"chapter",title:"Psychological Aspects of Kidney Transplantation",slug:"psychological-aspects-of-kidney-transplantation",totalDownloads:4649,totalCrossrefCites:1,signatures:"Magdalena Trzcinska and Zbigniew Włodarczyk",reviewType:"peer-reviewed",authors:[{id:"26139",title:"Dr",name:"Magdalena",middleName:null,surname:"Trzcinska",fullName:"Magdalena Trzcinska",slug:"magdalena-trzcinska"},{id:"35246",title:"Prof.",name:"Zbigniew",middleName:null,surname:"Wlodarczyk",fullName:"Zbigniew Wlodarczyk",slug:"zbigniew-wlodarczyk"}]},{id:"17953",type:"chapter",title:"Characteristics of Anaemia Management in Patients with Chronic Kidney Disease",slug:"characteristics-of-anaemia-management-in-patients-with-chronic-kidney-disease",totalDownloads:2589,totalCrossrefCites:1,signatures:"Zvonimir Puretic",reviewType:"peer-reviewed",authors:[{id:"40488",title:"MSc.",name:"Zvonimir",middleName:null,surname:"Puretic",fullName:"Zvonimir Puretic",slug:"zvonimir-puretic"}]},{id:"17954",type:"chapter",title:"Post Transplant Anaemia",slug:"post-transplant-anaemia",totalDownloads:2371,totalCrossrefCites:0,signatures:"Bhadran Bose and David Mudge",reviewType:"peer-reviewed",authors:[{id:"61923",title:"Dr.",name:"Bhadran",middleName:null,surname:"Bose",fullName:"Bhadran Bose",slug:"bhadran-bose"},{id:"172328",title:"Dr.",name:"David",middleName:null,surname:"Mudge",fullName:"David Mudge",slug:"david-mudge"}]},{id:"17955",type:"chapter",title:"New Onset Diabetes After Solid Organ Transplantation",slug:"new-onset-diabetes-after-solid-organ-transplantation",totalDownloads:2533,totalCrossrefCites:0,signatures:"Phuong-Thu T. Pham, Phuong-Mai T. Pham, Parikh S, Son V. Pham, Phuong-Anh T. Pham and Phuong-Chi T. Pham",reviewType:"peer-reviewed",authors:[{id:"41150",title:"Prof.",name:"Phuong-Thu",middleName:null,surname:"Pham",fullName:"Phuong-Thu Pham",slug:"phuong-thu-pham"}]},{id:"17956",type:"chapter",title:"Sexual and Reproductive Function in Chronic Kidney Disease and Effect of Kidney Transplantation",slug:"sexual-and-reproductive-function-in-chronic-kidney-disease-and-effect-of-kidney-transplantation",totalDownloads:14292,totalCrossrefCites:1,signatures:"Mahboob Lessan-Pezeshki and Shirin Ghazizadeh",reviewType:"peer-reviewed",authors:[{id:"26564",title:"Prof.",name:"Mahboob",middleName:null,surname:"Lessan Pezeshki",fullName:"Mahboob Lessan Pezeshki",slug:"mahboob-lessan-pezeshki"},{id:"26571",title:"Prof.",name:"Shirin",middleName:null,surname:"Ghazizadeh",fullName:"Shirin Ghazizadeh",slug:"shirin-ghazizadeh"}]},{id:"17957",type:"chapter",title:"Management of Bone Disease in Kidney Transplant Recipients",slug:"management-of-bone-disease-in-kidney-transplant-recipients",totalDownloads:4043,totalCrossrefCites:0,signatures:"Rubin Zhang and Brent Alper",reviewType:"peer-reviewed",authors:[{id:"32440",title:"Dr.",name:"Daniel",middleName:"J",surname:"Salzberg",fullName:"Daniel Salzberg",slug:"daniel-salzberg"},{id:"38681",title:"Dr.",name:"Heather",middleName:null,surname:"Jones",fullName:"Heather Jones",slug:"heather-jones"}]},{id:"17958",type:"chapter",title:"Hypertension in the Kidney Transplant Recipient",slug:"hypertension-in-the-kidney-transplant-recipient",totalDownloads:1925,totalCrossrefCites:0,signatures:"Heather H. Jones and Daniel J. Salzberg",reviewType:"peer-reviewed",authors:[{id:"32440",title:"Dr.",name:"Daniel",middleName:"J",surname:"Salzberg",fullName:"Daniel Salzberg",slug:"daniel-salzberg"},{id:"38681",title:"Dr.",name:"Heather",middleName:null,surname:"Jones",fullName:"Heather Jones",slug:"heather-jones"}]},{id:"17959",type:"chapter",title:"Diagnosis and Treatment of Status Epilepticus in a Pediatric Renal Recipient",slug:"diagnosis-and-treatment-of-status-epilepticus-in-a-pediatric-renal-recipient",totalDownloads:1777,totalCrossrefCites:0,signatures:"Gao Hong-jun, Luo xiangdong, Liang Taisheng, Liang Fangfang et al.",reviewType:"peer-reviewed",authors:[{id:"26371",title:"Prof.",name:"Hongjun",middleName:null,surname:"Gao",fullName:"Hongjun Gao",slug:"hongjun-gao"}]},{id:"17960",type:"chapter",title:"Chronic Allograft Nephropathy",slug:"chronic-allograft-nephropathy",totalDownloads:3693,totalCrossrefCites:0,signatures:"Harzallah Kais",reviewType:"peer-reviewed",authors:[{id:"26586",title:"Prof.",name:"Kais",middleName:null,surname:"Harzallah",fullName:"Kais Harzallah",slug:"kais-harzallah"}]},{id:"17961",type:"chapter",title:"Antibody-Mediated Kidney Allograft Rejection",slug:"antibody-mediated-kidney-allograft-rejection",totalDownloads:2653,totalCrossrefCites:0,signatures:"Xu Haiyan and He Xiaozhou",reviewType:"peer-reviewed",authors:[{id:"26644",title:"Prof.",name:"Xiaozhou",middleName:null,surname:"He",fullName:"Xiaozhou He",slug:"xiaozhou-he"},{id:"33821",title:"Dr.",name:"Haiyan",middleName:null,surname:"Xu",fullName:"Haiyan Xu",slug:"haiyan-xu"}]},{id:"17962",type:"chapter",title:"Pathogenesis and Preventive Strategies of Chronic Dysfunction of Renal Allograft",slug:"pathogenesis-and-preventive-strategies-of-chronic-dysfunction-of-renal-allograft",totalDownloads:2184,totalCrossrefCites:0,signatures:"Wenqian Huo, Keqin Zhang, Chengguo Ge, Gang Wu, Fengshuo Jin, Gang Yuan and Qiansheng Li",reviewType:"peer-reviewed",authors:[{id:"29156",title:"Prof.",name:"Wenqian",middleName:null,surname:"Huo",fullName:"Wenqian Huo",slug:"wenqian-huo"},{id:"30005",title:"Dr.",name:"Qiansheng",middleName:null,surname:"Li",fullName:"Qiansheng Li",slug:"qiansheng-li"},{id:"36703",title:"Prof.",name:"Keqin",middleName:null,surname:"ZHANG",fullName:"Keqin ZHANG",slug:"keqin-zhang"}]},{id:"17963",type:"chapter",title:"Delayed Graft Function",slug:"delayed-graft-function",totalDownloads:6243,totalCrossrefCites:0,signatures:"Qiansheng Li, Wenqian Huo, Keqin Zhang, Gang Wu, Fengshuo Jin, Xi Lin, Xiaojiang Jiang and Dong Gao",reviewType:"peer-reviewed",authors:[{id:"29156",title:"Prof.",name:"Wenqian",middleName:null,surname:"Huo",fullName:"Wenqian Huo",slug:"wenqian-huo"},{id:"30005",title:"Dr.",name:"Qiansheng",middleName:null,surname:"Li",fullName:"Qiansheng Li",slug:"qiansheng-li"},{id:"36703",title:"Prof.",name:"Keqin",middleName:null,surname:"ZHANG",fullName:"Keqin ZHANG",slug:"keqin-zhang"}]},{id:"17964",type:"chapter",title:"Factors Related to Graft Outcome in Pediatric Renal Transplantation: a Single Center Study",slug:"factors-related-to-graft-outcome-in-pediatric-renal-transplantation-a-single-center-study",totalDownloads:2683,totalCrossrefCites:0,signatures:"Jean Herman and Rita Van Damme-Lombaerts",reviewType:"peer-reviewed",authors:[{id:"28895",title:"Dr.",name:"Rita",middleName:null,surname:"Van Damme-Lombaerts",fullName:"Rita Van Damme-Lombaerts",slug:"rita-van-damme-lombaerts"},{id:"28909",title:"Dr.",name:"Jean",middleName:null,surname:"Herman",fullName:"Jean Herman",slug:"jean-herman"}]}]},relatedBooks:[{type:"book",id:"441",title:"Understanding the Complexities of Kidney Transplantation",subtitle:null,isOpenForSubmission:!1,hash:"46a4e22d63f105619b4bbf4b5631655c",slug:"understanding-the-complexities-of-kidney-transplantation",bookSignature:"Jorge Ortiz and Jason Andre",coverURL:"https://cdn.intechopen.com/books/images_new/441.jpg",editedByType:"Edited by",editors:[{id:"33534",title:"Prof.",name:"Jorge",surname:"Ortiz",slug:"jorge-ortiz",fullName:"Jorge Ortiz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"19039",title:"The History of Kidney Transplantation: Past, Present and Future (with Special References to the Belgian History)",slug:"the-history-of-kidney-transplantation-past-present-and-future-with-special-references-to-the-belgian",signatures:"Squifflet Jean-Paul",authors:[{id:"33849",title:"Prof.",name:"Jean-Paul",middleName:null,surname:"Squifflet",fullName:"Jean-Paul Squifflet",slug:"jean-paul-squifflet"}]},{id:"19040",title:"Ethical Controversies in Organ Transplantation",slug:"ethical-controversies-in-organ-transplantation",signatures:"Ehtuish Ehtuish",authors:[{id:"28892",title:"Prof.",name:"Ehtuish",middleName:null,surname:"Ehtuish",fullName:"Ehtuish Ehtuish",slug:"ehtuish-ehtuish"}]},{id:"19041",title:"Preemptive Kidney Transplantation",slug:"preemptive-kidney-transplantation",signatures:"Burak Sayin",authors:[{id:"26178",title:"Dr",name:"Burak",middleName:null,surname:"Sayin",fullName:"Burak Sayin",slug:"burak-sayin"}]},{id:"19042",title:"Proactive Management Approach in Prevention of Kidney Transplantation",slug:"proactive-management-approach-in-prevention-of-kidney-transplantation",signatures:"Levent B. Kıdak",authors:[{id:"26400",title:"Dr.",name:"Levent",middleName:"B.",surname:"Kıdak",fullName:"Levent Kıdak",slug:"levent-kidak"}]},{id:"19043",title:"Transplantation in Diabetics with End-Stage Renal Disease",slug:"transplantation-in-diabetics-with-end-stage-renal-disease",signatures:"Elijah Ablorsu",authors:[{id:"26190",title:"Mr.",name:"Elijah",middleName:null,surname:"Ablorsu",fullName:"Elijah Ablorsu",slug:"elijah-ablorsu"}]},{id:"19044",title:"Cardiovascular Diseases in Kidney Transplantation",slug:"cardiovascular-diseases-in-kidney-transplantation",signatures:"Roberto Marcén and Sara Jiménez",authors:[{id:"51103",title:"Dr.",name:"Roberto",middleName:null,surname:"Marcén",fullName:"Roberto Marcén",slug:"roberto-marcen"},{id:"51107",title:"Dr.",name:"Sara",middleName:null,surname:"Jimenez",fullName:"Sara Jimenez",slug:"sara-jimenez"}]},{id:"19045",title:"Obesity and Kidney Transplantation",slug:"obesity-and-kidney-transplantation",signatures:"Alex Chang, Susan Hou and Holly Kramer",authors:[{id:"28971",title:"Dr.",name:"Holly",middleName:null,surname:"Kramer",fullName:"Holly Kramer",slug:"holly-kramer"},{id:"39755",title:"Dr.",name:"Alexander",middleName:null,surname:"Chang",fullName:"Alexander Chang",slug:"alexander-chang"},{id:"39756",title:"Dr.",name:"Susan",middleName:null,surname:"Hou",fullName:"Susan Hou",slug:"susan-hou"}]},{id:"19046",title:"The Impact of Donor Type and Quality on Renal Transplant Outcomes",slug:"the-impact-of-donor-type-and-quality-on-renal-transplant-outcomes",signatures:"Hung Do Nguyen, Kenneth Yong, Rebecca Croke and Wai H Lim",authors:[{id:"26333",title:"Associate Prof.",name:"Wai",middleName:"Hon",surname:"Lim",fullName:"Wai Lim",slug:"wai-lim"},{id:"38112",title:"Dr.",name:"Hung",middleName:null,surname:"Do Nguyen",fullName:"Hung Do Nguyen",slug:"hung-do-nguyen"},{id:"38113",title:"Dr.",name:"Kenneth",middleName:null,surname:"Yong",fullName:"Kenneth Yong",slug:"kenneth-yong"},{id:"38114",title:"Dr.",name:"Rebecca",middleName:null,surname:"Croke",fullName:"Rebecca Croke",slug:"rebecca-croke"}]},{id:"19047",title:"Donor Quality Scoring Systems and Early Renal Function Measurements in Kidney Transplantation",slug:"donor-quality-scoring-systems-and-early-renal-function-measurements-in-kidney-transplantation",signatures:"Quirino Lai, Francesco Nudo, Vincenzo Morabito, Giovanni Battista Levi Sandri, Fabio Melandro, Lucia Parlati, Nicola Guglielmo, Marco Di Laudo, Manuela Garofalo, Luca Poli, Renzo Pretagostini and Pasquale B Berloco",authors:[{id:"29621",title:"Dr.",name:"Quirino",middleName:null,surname:"Lai",fullName:"Quirino Lai",slug:"quirino-lai"},{id:"33543",title:"Prof.",name:"Renzo",middleName:null,surname:"Pretagostini",fullName:"Renzo Pretagostini",slug:"renzo-pretagostini"},{id:"33545",title:"Prof.",name:"Pasquale B",middleName:null,surname:"Berloco",fullName:"Pasquale B Berloco",slug:"pasquale-b-berloco"},{id:"41383",title:"Dr.",name:"Luca",middleName:null,surname:"Poli",fullName:"Luca Poli",slug:"luca-poli"},{id:"83433",title:"Dr.",name:"Fabio",middleName:null,surname:"Melandro",fullName:"Fabio Melandro",slug:"fabio-melandro"},{id:"83434",title:"Dr.",name:"Nicola",middleName:null,surname:"Guglielmo",fullName:"Nicola Guglielmo",slug:"nicola-guglielmo"},{id:"98047",title:"Dr.",name:"Francesco",middleName:null,surname:"Nudo",fullName:"Francesco Nudo",slug:"francesco-nudo"},{id:"98049",title:"Dr.",name:"Giovanni Battista",middleName:null,surname:"Levi Sandri",fullName:"Giovanni Battista Levi Sandri",slug:"giovanni-battista-levi-sandri"},{id:"98050",title:"Dr.",name:"Lucia",middleName:null,surname:"Parlati",fullName:"Lucia Parlati",slug:"lucia-parlati"},{id:"98055",title:"Dr.",name:"Manuela",middleName:null,surname:"Garofalo",fullName:"Manuela Garofalo",slug:"manuela-garofalo"},{id:"98060",title:"Dr.",name:"Marco",middleName:null,surname:"Di Laudo",fullName:"Marco Di Laudo",slug:"marco-di-laudo"},{id:"101418",title:"Dr.",name:"Vincenzo",middleName:null,surname:"Morabito",fullName:"Vincenzo Morabito",slug:"vincenzo-morabito"}]},{id:"19048",title:"Donor Characteristics in 1,000 Consecutive Simultaneous Pancreas-Kidney Transplants",slug:"donor-characteristics-in-1-000-consecutive-simultaneous-pancreas-kidney-transplants",signatures:"Hans W. Sollinger, Jon S. Odorico, Glen E. Leverson, Barbara J. Voss and Anthony M. D’Alessandro",authors:[{id:"26540",title:"Dr.",name:"Hans",middleName:null,surname:"Sollinger",fullName:"Hans Sollinger",slug:"hans-sollinger"}]},{id:"19049",title:"Perioperative and Long-Term Safety of Living Kidney Donors",slug:"perioperative-and-long-term-safety-of-living-kidney-donors",signatures:"Masahiko Okamoto",authors:[{id:"26453",title:"Dr.",name:"Masahiko",middleName:null,surname:"Okamoto",fullName:"Masahiko Okamoto",slug:"masahiko-okamoto"}]},{id:"19050",title:"Perioperative Hydration Policy",slug:"perioperative-hydration-policy",signatures:"Mahmoud M. Othman",authors:[{id:"37254",title:"Prof.",name:"Mahmoud",middleName:"Mahmoud",surname:"Othman",fullName:"Mahmoud Othman",slug:"mahmoud-othman"}]},{id:"19051",title:"Anaesthesia for Kidney Transplantation",slug:"anaesthesia-for-kidney-transplantation",signatures:"Yasser Haggag and Imran Ahmad",authors:[{id:"25982",title:"Dr.",name:"Imran",middleName:null,surname:"Ahmad",fullName:"Imran Ahmad",slug:"imran-ahmad"},{id:"40412",title:"Dr.",name:"Yasser",middleName:null,surname:"Haggag",fullName:"Yasser Haggag",slug:"yasser-haggag"}]},{id:"19052",title:"Augmentation Cystoplasty: in Pretransplant Recepients",slug:"augmentation-cystoplasty-in-pretransplant-recepients",signatures:"Ashraf Abou-Elela",authors:[{id:"29432",title:"Dr.",name:"Ashraf",middleName:null,surname:"Abou-Elela",fullName:"Ashraf Abou-Elela",slug:"ashraf-abou-elela"}]},{id:"19053",title:"ABO-incompatible Kidney Transplantation",slug:"abo-incompatible-kidney-transplantation",signatures:"Mina Hur, Hee-Won Moon and Seog-Woon Kwon",authors:[{id:"39297",title:"Prof.",name:"Mina",middleName:null,surname:"Hur",fullName:"Mina Hur",slug:"mina-hur"},{id:"40133",title:"Prof.",name:"Hee-Won",middleName:null,surname:"Moon",fullName:"Hee-Won Moon",slug:"hee-won-moon"},{id:"40142",title:"Prof.",name:"Seog-Woon",middleName:null,surname:"Kwon",fullName:"Seog-Woon Kwon",slug:"seog-woon-kwon"}]},{id:"19054",title:"Combined Liver and Kidney Transplantation",slug:"combined-liver-and-kidney-transplantation",signatures:"Cláudia Fagundes and Mónica Guevara",authors:[{id:"62406",title:"Dr.",name:"Mónica",middleName:null,surname:"Guevara",fullName:"Mónica Guevara",slug:"monica-guevara"},{id:"62407",title:"Dr.",name:"Claudia",middleName:"Goncalves",surname:"Fagundes",fullName:"Claudia Fagundes",slug:"claudia-fagundes"}]},{id:"19055",title:"Transplantation for the Complex Patient with Hepatitis C and End Stage Renal Disease: A Review",slug:"transplantation-for-the-complex-patient-with-hepatitis-c-and-end-stage-renal-disease-a-review",signatures:"Jorge Ortiz, Jason Andre, Kamran Khanmoradi and Victor Araya",authors:[{id:"33534",title:"Prof.",name:"Jorge",middleName:null,surname:"Ortiz",fullName:"Jorge Ortiz",slug:"jorge-ortiz"},{id:"34295",title:"Prof.",name:"Jason",middleName:null,surname:"Andre",fullName:"Jason Andre",slug:"jason-andre"},{id:"34296",title:"Prof.",name:"Kamran",middleName:null,surname:"Khanmoradi",fullName:"Kamran Khanmoradi",slug:"kamran-khanmoradi"},{id:"34299",title:"Dr.",name:"Victor",middleName:null,surname:"Araya",fullName:"Victor Araya",slug:"victor-araya"}]},{id:"19056",title:"Combined Kidney-Islet Transplantation",slug:"combined-kidney-islet-transplantation",signatures:"Giuseppe Cavallari, Flavia Neri and Bruno Nardo",authors:[{id:"28982",title:"Prof.",name:"Bruno",middleName:null,surname:"Nardo",fullName:"Bruno Nardo",slug:"bruno-nardo"},{id:"40802",title:"Dr.",name:"Giuseppe",middleName:null,surname:"Cavallari",fullName:"Giuseppe Cavallari",slug:"giuseppe-cavallari"},{id:"78876",title:"Dr.",name:"Flavia",middleName:null,surname:"Neri",fullName:"Flavia Neri",slug:"flavia-neri"}]},{id:"19057",title:"Kidney-Pancreas Transplantation",slug:"kidney-pancreas-transplantation",signatures:"Farzad Kakaei and Saman Nikeghbalian",authors:[{id:"26626",title:"Dr.",name:"Farzad",middleName:null,surname:"Kakaei",fullName:"Farzad Kakaei",slug:"farzad-kakaei"},{id:"38685",title:"Dr.",name:"Saman",middleName:null,surname:"Nikeghbalian",fullName:"Saman Nikeghbalian",slug:"saman-nikeghbalian"}]},{id:"19058",title:"Clinical Pharmacokinetics of Triple Immunosuppression Scheme in Kidney Transplant (Tacrolimus, Mycophenolate Mofetil and Corticosteroids)",slug:"clinical-pharmacokinetics-of-triple-immunosuppression-scheme-in-kidney-transplant-tacrolimus-mycophe",signatures:"Robles Piedras Ana Luisa and Monroy Funes Manuel Alejandro",authors:[{id:"28947",title:"Dr.",name:"Ana Luisa",middleName:null,surname:"Robles Piedras",fullName:"Ana Luisa Robles Piedras",slug:"ana-luisa-robles-piedras"},{id:"40105",title:"Prof.",name:"Manuel Alejandro",middleName:null,surname:"Monroy-Funes",fullName:"Manuel Alejandro Monroy-Funes",slug:"manuel-alejandro-monroy-funes"}]},{id:"19059",title:"Desensitization and Induction Immunosuppressive Therapy in Highly HLA-Sensitized Patients Receiving Cadaveric Renal Allograft)",slug:"desensitization-and-induction-immunosuppressive-therapy-in-highly-hla-sensitized-patients-receiving-",signatures:"Juana Margarita Rufino Hernández, José Manuel González-Posada Delgado and Domingo Hernández Marrero",authors:[{id:"28272",title:"Dr.",name:"Juana Margarita",middleName:null,surname:"Rufino Hernandez",fullName:"Juana Margarita Rufino Hernandez",slug:"juana-margarita-rufino-hernandez"},{id:"104818",title:"Dr.",name:"José Manuel",middleName:null,surname:"Gonzalez-Posada Delgado",fullName:"José Manuel Gonzalez-Posada Delgado",slug:"jose-manuel-gonzalez-posada-delgado"},{id:"104819",title:"Dr.",name:"Domingo",middleName:null,surname:"Hernandez Marrero",fullName:"Domingo Hernandez Marrero",slug:"domingo-hernandez-marrero"}]},{id:"19060",title:"The Transplantation Operation and Its Surgical Complications",slug:"the-transplantation-operation-and-its-surgical-complications",signatures:"Junjie Zhao, Zhenli Gao and Ke Wang",authors:[{id:"27911",title:"Dr.",name:"Jun jie",middleName:null,surname:"Zhao",fullName:"Jun jie Zhao",slug:"jun-jie-zhao"},{id:"37544",title:"Dr.",name:"Zhen li",middleName:null,surname:"Gao",fullName:"Zhen li Gao",slug:"zhen-li-gao"},{id:"37545",title:"Dr.",name:"Ke",middleName:null,surname:"Wang",fullName:"Ke Wang",slug:"ke-wang"}]},{id:"19061",title:"Novel Renal Transplant-Related Surgical Approaches in the 21st Century",slug:"novel-renal-transplant-related-surgical-approaches-in-the-21st-century",signatures:"Shih-Chieh Jeff Chueh and Bashir R. Sankari",authors:[{id:"29359",title:"Prof.",name:"Shih-Chieh",middleName:"Jeff",surname:"Chueh",fullName:"Shih-Chieh Chueh",slug:"shih-chieh-chueh"},{id:"41285",title:"Dr.",name:"Bashir",middleName:null,surname:"Sankari",fullName:"Bashir Sankari",slug:"bashir-sankari"}]},{id:"19062",title:"Minimally Invasive Renal Transplantation",slug:"minimally-invasive-renal-transplantation",signatures:"Ole Øyen",authors:[{id:"32407",title:"Dr.",name:"Ole",middleName:null,surname:"Oyen",fullName:"Ole Oyen",slug:"ole-oyen"},{id:"32412",title:"Prof.",name:"Per",middleName:null,surname:"Pfeffer",fullName:"Per Pfeffer",slug:"per-pfeffer"}]},{id:"19063",title:"Surgical Complications of Renal Transplantation",slug:"surgical-complications-of-renal-transplantation",signatures:"Marcelo Ferreira Cassini, Murilo Ferreira de Andrade and Silvio Tucci Junior",authors:[{id:"26262",title:"Dr.",name:"Marcelo",middleName:null,surname:"Cassini",fullName:"Marcelo Cassini",slug:"marcelo-cassini"},{id:"40854",title:"Dr.",name:"Silvio",middleName:null,surname:"Tucci Jr",fullName:"Silvio Tucci Jr",slug:"silvio-tucci-jr"},{id:"40855",title:"Dr.",name:"Murilo",middleName:null,surname:"Andrade",fullName:"Murilo Andrade",slug:"murilo-andrade"}]},{id:"19064",title:"Vascular Complications in Kidney Transplantation",slug:"vascular-complications-in-kidney-transplantation",signatures:"Alexandros Giakoustidis, Nikolaos Antoniadis and Dimitrios Giakoustidis",authors:[{id:"32192",title:"Dr.",name:"Dimitrios",middleName:null,surname:"Giakoustidis",fullName:"Dimitrios Giakoustidis",slug:"dimitrios-giakoustidis"},{id:"40807",title:"Dr.",name:"Alexandros",middleName:null,surname:"Giakoustidis",fullName:"Alexandros Giakoustidis",slug:"alexandros-giakoustidis"},{id:"81460",title:"Dr.",name:"Nikolaos",middleName:null,surname:"Antoniadis",fullName:"Nikolaos Antoniadis",slug:"nikolaos-antoniadis"}]}]}],publishedBooks:[{type:"book",id:"5312",title:"Some Special Problems in Peritoneal Dialysis",subtitle:null,isOpenForSubmission:!1,hash:"3fbf9674e3eaf4eb57c06d764146fa36",slug:"some-special-problems-in-peritoneal-dialysis",bookSignature:"Robert Ekart",coverURL:"https://cdn.intechopen.com/books/images_new/5312.jpg",editedByType:"Edited by",editors:[{id:"56790",title:"Dr.",name:"Robert",surname:"Ekart",slug:"robert-ekart",fullName:"Robert Ekart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6537",title:"Evolving Strategies in Peritoneal Dialysis",subtitle:null,isOpenForSubmission:!1,hash:"76bb5dc2ce63f0026f7993b54f062861",slug:"evolving-strategies-in-peritoneal-dialysis",bookSignature:"Edward T. Zawada, Jr.",coverURL:"https://cdn.intechopen.com/books/images_new/6537.jpg",editedByType:"Edited by",editors:[{id:"16344",title:"Dr.",name:"Edward T.",surname:"Zawada Jr.",slug:"edward-t.-zawada-jr.",fullName:"Edward T. Zawada Jr."}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7276",title:"Advances in Nephropathy",subtitle:null,isOpenForSubmission:!1,hash:"487b332191e4266ae8e9d24b9b0a0985",slug:"advances-in-nephropathy",bookSignature:"Thomas Rath",coverURL:"https://cdn.intechopen.com/books/images_new/7276.jpg",editedByType:"Edited by",editors:[{id:"67436",title:"Dr.",name:"Thomas",surname:"Rath",slug:"thomas-rath",fullName:"Thomas Rath"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7935",title:"Renal Diseases",subtitle:null,isOpenForSubmission:!1,hash:"44715ed141cf23ebdd35ff0d772492df",slug:"renal-diseases",bookSignature:"Edward T. Zawada Jr. and Sohail Abdul Salim",coverURL:"https://cdn.intechopen.com/books/images_new/7935.jpg",editedByType:"Edited by",editors:[{id:"16344",title:"Dr.",name:"Edward T.",surname:"Zawada Jr.",slug:"edward-t.-zawada-jr.",fullName:"Edward T. Zawada Jr."}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8459",title:"Glomerulonephritis and Nephrotic Syndrome",subtitle:null,isOpenForSubmission:!1,hash:"404561518d53b3dd68ce74d6225588c0",slug:"glomerulonephritis-and-nephrotic-syndrome",bookSignature:"Thomas Rath",coverURL:"https://cdn.intechopen.com/books/images_new/8459.jpg",editedByType:"Edited by",editors:[{id:"67436",title:"Dr.",name:"Thomas",surname:"Rath",slug:"thomas-rath",fullName:"Thomas Rath"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[]},onlineFirst:{chapter:{type:"chapter",id:"78137",title:"Performance Evaluation of Waste Materials for the Treatment of Acid Mine Drainage to Remove Heavy Metals and Sulfate",doi:"10.5772/intechopen.99669",slug:"performance-evaluation-of-waste-materials-for-the-treatment-of-acid-mine-drainage-to-remove-heavy-me",body:'
1. Introduction
The extensive mining throughout the globe leads to generate a huge quantity of sulfides caused by weathering process (O2, moisture, and microbes), which promotes an acidic environment. The static/stream water in contact with mines and mines waste becomes a reaction site where it also acts as a reagent for deferent chemical reactions, i.e., metal/metalloid solubilization. Moreover, in-stream water, it also turns out to be a transport media for reaction products [1]. Such water constituents are called “acid mine drainage” or “acid and metalliferous drainage” (AMD) as shown in Figure 1. This water is generally characterized as lower pH value as well as a high heavy metals concentration such as iron, manganese, lead, chromium, mercury, cadmium, and arsenic and sulfate content [2]. AMD has a severe impact on the environment, including neighboring surfaces, groundwater, and soil properties. Various reports suggest that heavy metals transmit to the human body cause severe illness and death in AMD-contaminated areas. Therefore, to ensure human health safety and to control the environmental risk, AMD must be treated.
Figure 1.
Formation of AMD.
Various alkaline materials such as CaO, NaOH, CaCO3 have been appropriately examined in this chapter. The use of CaCO3 is more than other neutralizing material due to its cost-effectiveness. It produces less amount of sludge but the reaction period is comparably high than other chemical reagents. The major drawback of these alkaline reagents are high in cost and effectiveness in long-term periods is low. To avoid these major drawbacks, there is always a need for a better reagent, which is cheaper, eco-friendly, easy to handle, and the effectiveness in mitigating AMD wastewater. So various industrial by-products are examined by researchers. For example, the by-products generated from the Calcium oxide production process are used to treat sulfate and metals like cobalt, nickel, zing copper cadmium with better efficiency. Some other industrial outcomes like fly ash, steel slag, cement kiln dust, and bayer residue have possible calcium oxide and calcium hydroxide alternatives to treat AMD. The availability of these materials is generally high, which offers cost-effective neutralizing materials for the treatment process.
2. Characteristics of AMD wastewater
AMD is generally characterized by several physio-chemical properties. The chief physical properties are temperature, electrical conductivity, suspended and or dissolved solids whereas the chemical properties are mostly indicated by pH, alkalinity, acidity hardness, the concentration of metal ions, silica, salt, ammonium, and hydrocarbon contents, and radioactivity.
The physical and chemical properties depend on many factors which generally influence the oxidation process of sulfide minerals as well as promotes the migration and dilution of AMD. Hence, every mine has a different material property and should be studied carefully. In the mining sector for metal production, the most crucial factors are pH, the heavy metals concentration, and dissolved anion concentration, i.e., sulfate, chlorides, arsenates, nitrates, etc., and hardness as well as suspended solids. For a better characterization of AMD as well as the properties of waste which are affected by AMD is summarized into five common features listed as follows [3].
Acidity, and alkalinity property (pH)
The concentration of different heavy metals
Fe and Al concentration
Sulfate and Arsenate concentration
Transparency loss (turbidity and suspended solids)
2.1 Acidity/alkalinity property
The pH is the measure of H+ concentration; in the case of pure water, H+ and OH− are in the same concentration. If the H+ concentration is higher, it is acidic and if OH− is higher it becomes alkaline. The pH value of water decreases when it comes in contact with oxidized sulfides. For heavy metals, the lower pH value improves the solubility of the solution and is converted to a toxic solution.
The alkalinity is a measure of the base concentration of a solution and measured by the ability of the solution to absorb protons or the capacity to neutralize a strong acid. It also depends on the CO2 content and mineralization process. Thus total alkalinity is also known as the sum of OH−, CO32−, HCO3−, NH3, HS−, PO4−3, H2BO3−, and organic anions. The measurement of acidity indicates the total acid in the solution; also known as the capacity to neutralize the base.
The solution of a lower pH may contain different abundant acids. For pH higher than 7.0, total acidity rarely exists due to the lower value of sulfuric acid (H2SO4). The carbonate/bicarbonates convert into carbonic acid for pH less than 4.2, which then leads to the rapid dissociation into water and CO2 [4].
2.2 Concentration of different heavy metals
Different heavy metals of high concentrations are the common feature of AMD. Some metals in the metal deposits often incorporate into the AMD at specific geochemical conditions. The toxicity level is a greater problem to aquatic life as well as human health. The control mechanism of heavy metals is quite complex and highly precise to metal and site. In the initial stage where AMD forms, the type of metallic minerals and their solubilities and or dissolution rate control the concentrations of heavy metal. In the second development stage, effluent evolves in contact with regional rocks, atmospheric conditions, and water, changes occur in the complex of metal which favor adsorption and precipitation, so control and mitigate AMD flow [5].
2.3 Iron and aluminum concentration
Iron and aluminum have different geochemical conditions than other heavy metals present in AMD. These two elements are considered seriously due to their higher concentration and effects over other metals. They form a coating along the water stream known as yellow-orange Fe oxy-hydroxides and white-yellow Al oxy-hydroxides as shown in Figure 2. For low solubility in nature, these two metals under natural conditions form coloration over the water stream for a long time [6].
Figure 2.
Coloration of AMD water.
2.4 Sulphate and arsenate concentration
Sulphate concentration is the most consistent feature of AMD as its origin comes from sulphate oxidation. Various studies show that the effectiveness of sulphide oxidation depends on sulphate concentration and flow of effluent from the zone of oxidation and any subsequent dilution. Arsenate does not form in such a higher concentration as that of sulphate but this metal has a different area of concern due to its toxic nature [7].
2.5 Turbidity and suspended solids
Turbidity refers to the light absorbance capacity of water preventing its transmission into depth. It is affected by the suspended solids, dissolved solids, and also plankton present in the solution. The measurement of total suspended solids in the laboratory studies indicated various disadvantages related to turbidity; during the storage of these samples, precipitation and flocculation occur. Particles can constitute suspended solid (SS) corresponding to AMD, and macromolecular colloidal particles of aluminum/iron-oxyhydroxides, macroscopic particles, and compounds such as silt and clay. Both the total suspended solids (TSS) and turbidity are of great importance corresponding to the transport phenomena of arsenic and heavy metals in the absorption process, to adverse the water quality and lower down the negative gradient on aquatic life. Also some other factors which is responsible for AMD are shown in Figure 3 [8].
Figure 3.
Various factors for the formation of AMD.
3. Occurrence of acid mine drainage
AMD normally has a lower value of pH, higher specific conductivity, high concentration of heavy metals such as iron, aluminum, and manganese, and low concentration of heavy metals viz. chromium, nickel, cobalt, arsenic, and so on. The pyrite mineral which is responsible for occurrence of AMD is shown in Figure 4. In the current scenario, AMD is left untreated due to inadequate, underdeveloped technologies and or infeasible processes (expensive) in various parts of the globe. The acid generation reaction due to pyrite oxidation, which is widely known as one of the sulphide minerals is given in Eq. (1). The oxidation reaction results in dissolved Fe, sulphate, and hydrogen as reaction products [9, 10].
FeS2+72.O2+H2O⇾Fe2++2.SO42−+2.H+E1
Figure 4.
Pyrite mineral.
As the reaction indicated in Eq. (1) moves in the forward direction, the reaction products ferrous iron, sulphate, and hydrogen cataion increase the total dissolved solids (TDS) and hence acidity by lowering pH of solution [11]. If the adjacent surroundings get sufficiently oxidized (depending on oxygen concentration, pH, and microbial activity), much of the Fe2+ will be oxidized into Fe3+ as expressed in Eq. (2).
Fe2++14.O2+H+⇾Fe3++12.H2OE2
For pH equals 2.3 and 3.5, the ferric iron (Fe3+) precipitates as Fe(OH)3 and [KFe3(SO4)2(OH)6], respectively, a low Fe3+ retains in solution which lowers the pH.
Fe3++3.H2O⇾FeOH3solid+3H+E3
The leftover Fe3+ in Eq. (2) which remains unreacted in Eq. (3) might promote oxidation of additional pyrite as per Eq. (4).
FeS2+14Fe3++8.H2O⇾15.Fe2++2.SO42−+16H+E4
The aforementioned basic reactions suggest that the acid generation produces ferric iron which gradually precipitates into Fe(OH)3 and may be represented as Eq. (5) which is a combined reaction of Eqs. (1) and (3).
FeS2+154.O2+72.H2O⇾FeOH3+2.SO42−+4H+E5
In another way, Eq. (6) represents the overall reaction for stable Fe3+ used to oxidize additional pyrite.
In all of the above equations except Eqs. (2) and (3), the oxidant and oxidized mineral are presumed as oxygen and pyrite, respectively. However, pyrrhotite and chalcocite minerals contain altered proportions of metal sulfide and also metals excluding iron [12].
When the water is adequately acidic, acidophilic microbes that flourish at low pH can build up themselves. The microorganism “Thiobacillus Ferroxidans” is assumed to take a huge part in accelerating the synthetic response occurring in mine water circumstances, i.e., these microbes catalyze the oxidation of Fe2+. Another microorganism “Ferroplasma Acidarmanus” has recently been found to play an important role in acid generation in the source water.
Although the formation of H+ as a result of certain metals precipitations expressed in Eqs. (7) and (8) are not the major acidity sources, these also are considered as treatment alternatives [13].
Fe+3/Al+3+3.H2O⇾FeOH3/AlOH3+3.H+E7
Fe+2/Mn++0.25O2aq.+2.5H2O⇾FeOH3/MnOH3+2H+E8
Different metals are normally found in AMD because they are available in rocks, like pyrite. There are different metal sulphides viz. ZnS, PbS, NiS, CdS, CuS, etc. which may deliver metal particles into solution but may not produce acidity. The key factors determining the acid generation rate are as follows.
Water pH and environment temperature
Oxygen concentration aqueous solution
Saturation degree (in water)
Chemical activity of ferric iron
Exposed surface area
Chemical energy (activation) to initiate acid generation
Presence of bacteria that promote oxidation
In the special case where microbial acceleration is significant, some other factors such as activation energy (biological), population density (microbes), and growth rate determine the activity of bacterial. The growth rate depends on pH, temperature, and the presence of various nutrients like nitrate, potassium, ammonia, phosphorous and CO2 content.
4. Environmental impact of acid mine drainage
AMD shows unique characteristics because the formation and generation of acidic water continue even after the mining area is ceased. So this acidic nature of water is not suitable for the human, animal as well as aquatic life. This problem of the acidic nature of water is not restricted to a limited area near the source of generation but extended to a larger area if this water gets discharged to the main water stream [14]. The AMD has generally more impact on the groundwater than that of the quality of surface water [15]. If the mines which are producing acidic water are present in the permeable formation, this acidic water (low pH) penetrates the aquifer and spreads into and over a larger area with the movement of groundwater which is used by human beings in different ways like wells and bore wells. This acidic and Fe-contaminated water is not only the key reason for corrosion in mine plant equipment by forming scales on the delivery pipe but also pollute the mining atmosphere and surrounding ecosystem [16].
AMD has a serious impact on human heal as well as the ecosystem due to the presence of heavy metals which are not degradable and causes various diseases and disorders in living organisms as well as the plant physiology which is given in the Table 1. Various impact of AMD has been shown in Figure 5. The pH of this water is very low so the heavy metals present in this water are insoluble and its high concentration causes a toxicological effect on aquatic life. This high presence of metals in water can kill the organisms directly and in the long term effect, lowers the growth and reproduction rates.
Heavy metal
Effect on human health
Effect on plant physiological
Permissible level (mg/L)
Cu
Anemia, liver and kidney damage
Inhibits photosynthesis and reproductive process
0.10
Cd
Renal dysfunction, lung infection, and cancer
Decreases seed germination and lipid content
0.01
Zn
Damage to the nervous system
Reduces Ni toxicity, promotes plant development
5.0
Ni
Allergic contact dermatitis, chronic bronchitis, lung, and nasal cancer
0.05
As
Bronchitis, Skin and bladder disease, kidney damage, bone marrow depression
Growth inhibition, Loss of yield and fruit production, Food chain harming
0.05
Mn
Affect the central nervous system
Decreases seed germination, protein, and enzyme
0.1
Hg
Impaired neurodevelopment, decrease in memory
Decreases photosynthetic activity, water uptake, and antioxidant
0.001
Pb
Mental retardation in children, developmental delay
Reduces chlorophyll production and development of plant
0.10
Cr
Affect the nervous system, fatigue, and irritability
Decreases enzyme activity, development of plant; Causes membrane damage, chlorosis, and root damage
0.05
Table 1.
Influence of heavy metals on animals and plants.
Figure 5.
Several impacts of AMD.
5. Treatment technology for AMD
Treatment of AMD is broadly classified into active and passive treatments which is clearly shown in Figure 6 [17]. The active method is more complicated and required more unit measures and the operational cost is high than other treatment methods like passive treatment. The various strategy applied by the various nations for the AMD treatment comprising precipitation, neutralization, ion exchange, electrochemical remediation, adsorption oxidation, etc. All these methods are used for wastewater treatment among which the adsorption technique is the most suitable method for being comparatively economically viable and eco-friendly [18].
Figure 6.
AMD treatment methods.
5.1 Active technologies for the treatment of AMD
The appropriate strategy used to mitigate wastewater (acidic) that includes the expansion of a chemically neutralizing agent is known as active treatment. The addition of various basic materials will improve the pH and accelerate the oxidation process (chemical) of (Fe2+) and precipitation of different metals into hydroxide and carbonates. The different neutralizing agents viz. lime, slaked lime, sodium-carbonate/hydroxide, calcium/magnesium-carbonate/hydroxide can be utilized which is shown in Figure 7; differ in cost and efficiency. Although active chemical treatment has better efficiency for mitigation of AMD water, it has a disadvantage of high operational cost and produces more amount of sludge as an effluent. In this treatment process a variety of refinements to improve its efficiency and minimizes the sludge-related problems. The different flocculating reagent is added to increase precipitation. The iron-rich sludge created by the expansion of basic material is highly voluminous and rich in water. This sludge is used as a recycling process by dewatering the sludge in a lime-holding tank [19].
Figure 7.
Common neutralizing reagents.
The cost for AMD treatment depends on the location and different scenarios like requirements of manpower, mechanical equipment, and dispensing facilities, and also cost. Soda ash, caustic soda, and ammonia have the lowest cost due to the less expensive equipment needed for the operation. Calcium oxide has the highest cost of installation because of the construction of a lime treatment plant and an aerator. The calcium hydroxide cost is low but the operation cost is high which is used for a long period of treatment for high loading and high acidic condition. Different active technology method which are generally followed for the treatment of AMD is given in Table 2.
Sl. No.
Methodology
Membrane used
Feed solutions
Experimental condition
Percentage removal
1.
Reverse osmosis
Cellulose acetate membrane
Fe, Cu, Zn, Ca, Mg, Mn, Ni, and A1
Product rate 26.2 g/hr. for an effective surface area of 13.4 cm2
Removal efficiency of Fe3+, Mn2+, Zn2+, and Cu− was 80%, 95%, 90%, and 99% respectively [24]
Table 2.
Different active treatment technology.
5.2 Passive technologies for the treatment of AMD
The passive treatments of AMD rely upon biological, physical, and geochemical cycles to improve the nature of water. Primary passive methods can be compressively separated into biological and geochemical systems/reactors that use inorganic substances such as carbonates. The biological systems contain anaerobic and vertical flow wetlands, bioreactors. The geochemical systems include limestone drains, open limestone channels, limestone/steel slag leach beds, limestone sand. The selection of an effective passive treatment method relies on the water chemistry, flow rate, local topography, and characteristics of the site [25].
5.3 Treatment using various waste materials
Active treatment methods are adopted in a wide range but they cause high establishment and absorbent expense. Also, some treatment methods associated with the active process like reverse osmosis, ion exchange requires pre-treatment of influent which is mentioned in the Table 2. Waste materials are generally economical than any other treatment method also reduces the environmental load. Various waste material which are generally used for the Treatment process of AMD are given in Table 3. They have the capacity and effectiveness to improve the pH of the AMD water and also to remove various pollutants from the wastewater. These waste materials provide a larger surface area, increasing the pH and adsorption rate to remove various pollutants at different concentrations [34, 35].
Sl. No.
Used material
Optimum mixing ratio/dose
Initial pH
Final pH
Reaction time
The percentage removal of metals
1.
Fly ash
1:3
2.78
9.1
1440 mins
Greater than 90% for toxic metals, 78% for sulfate [26]
2.
Coal fly ash
—
4
7.0
12 hrs.
60.4% sulfate, 53.4% chemical oxygen demand and removal of Cd2+, Cu2+ and Zn2+ were 42.9%, 74.8% and 26.7% [27]
3.
FA followed by seeding with gypsum crystals and the addition of amorphous Al(OH)3
Removal of 36% Fe, 26% Al, 20% Zn, 35% Cu, 43% Cd, 98% Pb,40% Ni, 21% Co [34]
Table 3.
Removal of metals using different waste material.
5.3.1 Fly ash
Fly ash is an unconventional, eco-friendly, low-cost material used as an alternative absorbent for activated carbon. Various research has also suggested that it has also an alternate material to dolomite and limestone used for the pre-treatment process [36]. This waste is used for the treatment of AMD which is successfully removed various heavy metals viz. manganese calcium, iron, aluminum, cadmium, cobalt, zinc, nickel respectively; increases the pH of the solution [26]. The efficiency of fly ash depends on the fly ash characteristics viz. the concentration of CaO and MgO. Initially, the concertation of Ca and Mg increases due to the leaching effect of Ca2+ and Mg2+ from fly ash surface. But later when gypsum is formed (made of oxygen, sulfur, calcium, and water), concentration Ca and Mg decreases. As the water starts evaporation, it does not protect the sulfur and oxygen-sulfur bonding forms a sulfate (SO42−). The sulfate then bonds with calcium (Ca) and water (H2O) to create gypsum and the Ca concentration decreases. Formation of gypsum occurs at pH >5.5 and absorbs sulphate with high concentration by Fe(OH)2 at pH > 6. Fly ash not only treats heavy metals but also helps in the removal of radioactive material from mine water. It acts as a sink property for the degradation of heavy metals like uranium and thorium. The free CaO present in fly ash attributes to the sulphate removal rate, precipitates gypsum.
5.3.2 Biomass ashes
The synergistic solution is turning out to be exceptionally attractive for sustainability and circular economy where the waste from one industry becomes an asset for another industry, Biomass ash, which is a result of consuming biomass in a power station, can be considered as an effective material for the treatment of acidic water. This ash is a complex alkaline mixture with poly-component, heterogeneous and different variety of composition. Biomass burning is a significant part of worldwide eco-friendly power which is developing very rapidly overall. Research suggested that the amount of biomass ashes created around the world is 480 Mtpa which can be compared to the coal ash, i.e., 780 Mtpa. Both coal and biomass ashes are generally alkaline and their pH ranges between 9 and 12. They are different in composition such as coal consist of oxides of silicon, aluminum, and iron and content less mount of calcium oxide also the presence of some heavy metals.
5.3.3 BOF and SAF slags
Basic oxygen furnace (BOF) and submerged arc furnace (SAF) slags have complex physical and chemical characteristics [30]. These materials are composed of oxides of calcium, silicon, phosphorus, sulfur, and manganese produced in steel refining processes. Depending upon the sufficiency of the cleaning cycle, inadequately Fe and entrapped metal droplets during the tapping also incorporate into BOF/SAF slags. Because of the popularity of steel, which is linked to the increase in population results during the production cycle of steel produces more amount of BOF and SAF slags from the production process. Various studies suggested that every year steel industry produced is about 100–200 kg of slag as by-products. After the production, the slags are partially reprocessed but a major part of the slag is used as a landfill material and holds pond and lagoon due to the less demand in the market. This slag raises the pH of AMD and reduces the chemical elements (pollutants) to the desired amount. However, it partially removes the sulphate and also various metals such as Mn, Ni, Co, Zn, Mg. This slag is an ideal candidate for the treatment of AMD and also minimizes the environmental impact with the disposal process of these slags [37].
5.3.4 Eggshell waste
Now a day’s egg production rates are higher in various countries so that the waste shell produces from eggs are increasing rapidly [38]. According to the study, the global egg production rate is approaching 86.8 Mtpa globally per year soon. This material is used as alternative treatment material to treat AMD. The primary constituent of ES is CaCO3 is an alkaline material that reacts with acidic water to neutralize it by the process of adsorption and precipitation of metals and also used for the complex, binding, and ion exchange material for various metals ions in the wastewater (Equation 9). This eggshell waste is a very cheap and biodegradable material which are collected, characterized, prepared, and evaluated for the degradation of various anions like aluminum, iron, manganese, and anions like sulphate present in AMD. Due to similar properties like limestone, it can be a good neutralizing agent [39].
CaCO3+H2SO4→CaSO4+CO2+H2OE9
6. Discussion
In the above, various discussions have been made for remediation of AMD wastewater, emphasizing waste materials used for the treatment process. Prevention measures play an essential role in controlling AMD formation, but the plan should be made for proper treatment if it can exceed a dangerous level. It is often not wholly possible, requiring corrective techniques to reduce or remove contamination from water. Active and passive treatment methods are mainly utilized to mitigate AMD and improve the quality of the water. Still, their maintenance cost is high, slow treatment process, and requires a large area for operation. But the waste materials play an essential role in mitigating AMD. Different factors like surface area, pH increasing ability, leachability of the material, retention time, cost factor, and environmental impact must be considered when choosing a waste material. The finding results of these waste materials are described below:
Fly ash and cement kiln dust rich in lime content have better efficiency in removing heavy metals than any other waste material with different pH values.
Iron and steel slag have ion exchange and sorption properties to degrade metals from the liquid solution.
BOF and SOF slag are given the same results to increase the pH value above 8 of the aqueous solution; as a result, precipitation of metals occurs.
The surface area and pH of modified fly ash have more than the fly ash. It requires more reaction time and dose for the absorption process.
Rice husk was found to be a better reagent and can grow the D. nigrificans, also known as sulfate-reducing bacteria.
The peat humic agent is also used as an alternative to treat wastewater and can modify kaolinite clay to increase the sorption property of the clay, which can absorb the heavy metals within a pH range of 5 to 8.5.
Eggshell waste can remove the aluminum and iron content at low temperatures but required a high temperature to remove manganese.
7. Conclusions
This chapter concluded that the demand of various waste materials to be tasted due to their characteristics to determine the suitable condition and amount of dose required to remove metals by absorption process from the AMD. This process also generates some new waste streams and some waste materials that cannot completely remove heavy metals from mine wastewater. So further research and innovation are required to address this issue associated with AMD.
Acknowledgments
We would like to thank National institute of Technology, Rourkela for the support.
Conflict of interest
The authors declare no conflict of interest. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
\n',keywords:"Acid Mine Drainage, Fly Ash, Metallurgical Slag, Zero Valent Iron, Organic waste",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/78137.pdf",chapterXML:"https://mts.intechopen.com/source/xml/78137.xml",downloadPdfUrl:"/chapter/pdf-download/78137",previewPdfUrl:"/chapter/pdf-preview/78137",totalDownloads:123,totalViews:0,totalCrossrefCites:0,dateSubmitted:"March 29th 2021",dateReviewed:"July 27th 2021",datePrePublished:"October 19th 2021",datePublished:"February 2nd 2022",dateFinished:"August 17th 2021",readingETA:"0",abstract:"Acid Mine Drainage (AMD) is the most severe environmental problem facing the mining sector in the current scenario because of low pH and high pollutants concentration. AMD contains a high amount of sulphate viz. pyrite, FeS2, and to a lesser extent pyrrhotite and heavy metal ions, contaminate both surface water and groundwater. To treat AMD, extensive research projects have been initiated by governments, the mining industry, universities, and research establishments. The environmental impact of AMD can be minimized at these basic levels; prevention should be taken to control the infiltration of groundwater to the pollution site and control the acid-generating process. There are some conventional active methods to treat AMD, such as compost reactor and packed bed iron-oxidation bioreactors; however, these methods have associated with costly material and high maintenance cost, which increases the cost of the entire treatment. In an alternative, the use of low-cost materials such as fly ash, metallurgical slag, zero-valent iron (ZVI), cement kiln dust (CKD), and organic waste such as peat humic agent (PHA), rice husk, and eggshell can be a valuable measure for economic viability to treat the metal-rich wastewater.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/78137",risUrl:"/chapter/ris/78137",signatures:"Satish Chandra Bhuyan, Subrat Kumar Bhuyan and Himanshu Bhushan Sahu",book:{id:"11074",type:"book",title:"Water Quality",subtitle:"Factors and Impacts",fullTitle:"Water Quality - Factors and Impacts",slug:"water-quality-factors-and-impacts",publishedDate:"February 2nd 2022",bookSignature:"Daniel Dunea",coverURL:"https://cdn.intechopen.com/books/images_new/11074.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-548-3",printIsbn:"978-1-83969-547-6",pdfIsbn:"978-1-83969-549-0",isAvailableForWebshopOrdering:!0,editors:[{id:"180202",title:"Associate Prof.",name:"Daniel",middleName:null,surname:"Dunea",slug:"daniel-dunea",fullName:"Daniel Dunea"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"332527",title:"Mr.",name:"Subrat Kumar",middleName:null,surname:"Bhuyan",fullName:"Subrat Kumar Bhuyan",slug:"subrat-kumar-bhuyan",email:"subratbhuyan2014@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"345628",title:"Mr.",name:"Satish",middleName:"Chandra",surname:"Bhuyan",fullName:"Satish Bhuyan",slug:"satish-bhuyan",email:"satishbhuyan2015@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"345761",title:"Prof.",name:"Himanshu Bhusan",middleName:null,surname:"Sahoo",fullName:"Himanshu Bhusan Sahoo",slug:"himanshu-bhusan-sahoo",email:"hbsahu@nitrkl.ac.in",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"National Institute of Technology Rourkela",institutionURL:null,country:{name:"India"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Characteristics of AMD wastewater",level:"1"},{id:"sec_2_2",title:"2.1 Acidity/alkalinity property",level:"2"},{id:"sec_3_2",title:"2.2 Concentration of different heavy metals",level:"2"},{id:"sec_4_2",title:"2.3 Iron and aluminum concentration",level:"2"},{id:"sec_5_2",title:"2.4 Sulphate and arsenate concentration",level:"2"},{id:"sec_6_2",title:"2.5 Turbidity and suspended solids",level:"2"},{id:"sec_8",title:"3. Occurrence of acid mine drainage",level:"1"},{id:"sec_9",title:"4. Environmental impact of acid mine drainage",level:"1"},{id:"sec_10",title:"5. Treatment technology for AMD",level:"1"},{id:"sec_10_2",title:"5.1 Active technologies for the treatment of AMD",level:"2"},{id:"sec_11_2",title:"5.2 Passive technologies for the treatment of AMD",level:"2"},{id:"sec_12_2",title:"5.3 Treatment using various waste materials",level:"2"},{id:"sec_12_3",title:"5.3.1 Fly ash",level:"3"},{id:"sec_13_3",title:"5.3.2 Biomass ashes",level:"3"},{id:"sec_14_3",title:"5.3.3 BOF and SAF slags",level:"3"},{id:"sec_15_3",title:"5.3.4 Eggshell waste",level:"3"},{id:"sec_18",title:"6. Discussion",level:"1"},{id:"sec_19",title:"7. Conclusions",level:"1"},{id:"sec_20",title:"Acknowledgments",level:"1"},{id:"sec_23",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'S Saha AS. Review on treatment of acid mine drainage with waste materials: A Novel Approach. Glob NEST J. 2018 Sep;20(3):512–528.'},{id:"B2",body:'Jones SN, Cetin B. Evaluation of waste materials for acid mine drainage remediation. Fuel. 2017 Jan 15;188:294–309.'},{id:"B3",body:'Favas PJC, Sarkar SK, Rakshit D, Venkatachalam P, Prasad MNV. Acid mine drainages from abandoned mines. In: Environmental Materials and Waste. Elsevier; 2016. p. 413–462.'},{id:"B4",body:'Koski RA, Munk LA, Foster AL, Shanks WC, Stillings LL. Sulfide oxidation and distribution of metals near abandoned copper mines in coastal environments, Prince William sound, Alaska, USA. Appl Geochemistry. 2008 Feb 1;23(2):227–254.'},{id:"B5",body:'Soltani N, Moore F, Keshavarzi B, Quality RS-W, and E, 2014 undefined. Geochemistry of trace metals and rare earth elements in stream water, stream sediments and acid mine drainage from Darrehzar Copper Mine, Kerman, Iran. Springer [Internet]. [cited 2021 Jun 21]; Available from: https://link.springer.com/content/pdf/10.1007/s12403-014-0114-x.pdf'},{id:"B6",body:'No Title. FicMin WH, Plurnlee GS, Smith KS Geol geochemical Control Compos water draining from Divers Miner Depos Cart LMH, Toth, MI, Day, W USGS Res Miner Resour U S Geol Surv Circ 1994;1.'},{id:"B7",body:'Schrniermund RL, Drozd MA. Acid Mine Drainage and Other. 1997;599. Available from: https://www.worldscientific.com/doi/pdf/10.1142/9781860943768_0013'},{id:"B8",body:'Hydrometallurgy DJ-, 2006 undefined. Biohydrometallurgy and the environment: intimate and important interplay. Elsevier [Internet]. [cited 2021 Jun 21]; Available from: https://www.sciencedirect.com/science/article/pii/S0304386X06000855'},{id:"B9",body:'Pozo-Antonio S, Puente-Luna I, Lagüela-López S, Veiga-Ríos M. Techniques to correct and prevent acid mine drainage: A review. DYNA. 2014 Aug;81(186):73.'},{id:"B10",body:'Akcil A, Koldas S. Acid mine drainage (AMD): Causes, treatment and case studies. Vol. 14, Journal of Cleaner Production. 2006. p. 1139–1145.'},{id:"B11",body:'Simate GS, Ndlovu S. Acid mine drainage: Challenges and opportunities. J Environ Chem Eng. 2014 Sep;2(3):1785–1803.'},{id:"B12",body:'Ben Ali HE, Neculita CM, Molson JW, Maqsoud A, Zagury GJ. Salinity and low temperature effects on the performance of column biochemical reactors for the treatment of acidic and neutral mine drainage. Chemosphere. 2020 Mar;243:125303.'},{id:"B13",body:'Yan S, Cheng KY, Morris C, Douglas G, Ginige MP, Zheng G, et al. Sequential hydrotalcite precipitation and biological sulfate reduction for acid mine drainage treatment. Chemosphere. 2020 Aug;252:126570.'},{id:"B14",body:'Vandeginste V, Cowan C, Gomes RL, Hassan T, Titman J. Natural fluorapatite dissolution kinetics and Mn2+ and Cr3+ metal removal from sulfate fluids at 35 °C. J Hazard Mater. 2020 May 5;389.'},{id:"B15",body:'Moodley I, Sheridan CM, Kappelmeyer U, Akcil A. Environmentally sustainable acid mine drainage remediation: Research developments with a focus on waste/by-products. Miner Eng. 2018 Sep;126:207–220.'},{id:"B16",body:'Skousen JG, Ziemkiewicz PF, McDonald LM. Acid mine drainage formation, control and treatment: Approaches and strategies. Extr Ind Soc. 2019 Jan;6(1):241–249.'},{id:"B17",body:'Genç H, Tjell JC, McConchie D, Schuiling O. Adsorption of arsenate from water using neutralized red mud. J Colloid Interface Sci. 2003 Aug 15;264(2):327–334.'},{id:"B18",body:'Apiratikul R, Pavasant P. Sorption of Cu2+, Cd2+, and Pb2+ using modified zeolite from coal fly ash. Chem Eng J. 2008 Oct;144(2):245–258.'},{id:"B19",body:'Qiu W, Zheng Y. Removal of lead, copper, nickel, cobalt, and zinc from water by a cancrinite-type zeolite synthesized from fly ash. Chem Eng J. 2009 Jan;145(3):483–488.'},{id:"B20",body:'Sastri VS. Reverse osmosis separation of metal ions in acid mine-water. Sep Sci Technol. 1979 Oct 1;14(8):711–719.'},{id:"B21",body:'Zhong CM, Xu ZL, Fang XH, Cheng L. Treatment of acid mine drainage (AMD) by ultra-low-pressure reverse osmosis and nanofiltration. Environ Eng Sci. 2007 Nov 1;24(9):1297–1306.'},{id:"B22",body:'Feng D, Aldrich C, Engineering HT-M, 2000 undefined. Treatment of acid mine water by use of heavy metal precipitation and ion exchange. Elsevier [Internet]. [cited 2021 Jun 24]; Available from: https://www.sciencedirect.com/science/article/pii/S0892687500000455'},{id:"B23",body:'Buzzi D, Viegas L, … MR-M, 2013 undefined. Water recovery from acid mine drainage by electrodialysis. Elsevier [Internet]. [cited 2021 Jun 24]; Available from: https://www.sciencedirect.com/science/article/pii/S0892687512002750'},{id:"B24",body:'Motsi T, Rowson N, Mineral MS-IJ of, 2009 undefined. Adsorption of heavy metals from acid mine drainage by natural zeolite. Elsevier [Internet]. [cited 2021 Jun 24]; Available from: https://www.sciencedirect.com/science/article/pii/S0301751609000349'},{id:"B25",body:'Bäckström M, Sartz L. Mixing of acid rock drainage with alkaline ash leachates—Fate and immobilisation of trace elements. Water, Air, Soil Pollut. 2011 Nov;222(1–4):377–389.'},{id:"B26",body:'Gitari WM, Petrik LF, Etchebers O, Key DL, Okujeni C. Utilization of fly ash for treatment of coal mines wastewater: Solubility controls on major inorganic contaminants. Fuel [Internet]. 2008 Sep;87(12):2450–2462. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0016236108001075'},{id:"B27",body:'Jianping X, Haitao W. Study on the Treatment of Acid Mine Wastewater by Coal Fly Ash [Internet]. atlantis-press.com. 2014 [cited 2021 Jun 24]. Available from: https://www.atlantis-press.com/proceedings/icmaee-14/11479'},{id:"B28",body:'Madzivire G, Maleka P, … VV-J of environmental, 2014 undefined. Fate of the naturally occurring radioactive materials during treatment of acid mine drainage with coal fly ash and aluminium hydroxide. Elsevier [Internet]. [cited 2021 Jun 24]; Available from: https://www.sciencedirect.com/science/article/pii/S0301479713007342'},{id:"B29",body:'Sahoo PK, Tripathy S, Panigrahi MK, Equeenuddin SM. Evaluation of the use of an alkali modified fly ash as a potential adsorbent for the removal of metals from acid mine drainage. Appl Water Sci. 2013 Sep;3(3):567–576.'},{id:"B30",body:'Feng D, van Deventer JSJ, Aldrich C. Removal of pollutants from acid mine wastewater using metallurgical by-product slags. Sep Purif Technol [Internet]. 2004 Nov;40(1):61–67. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1383586604000061'},{id:"B31",body:'Name T, Engineering CS-M, 2014 undefined. Remediation of acid mine drainage using metallurgical slags. Elsevier [Internet]. [cited 2021 Jun 24]; Available from: https://www.sciencedirect.com/science/article/pii/S0892687514001046'},{id:"B32",body:'Mackie A, research MW-W, 2012 undefined. Bench-scale study of active mine water treatment using cement kiln dust (CKD) as a neutralization agent. Elsevier [Internet]. [cited 2021 Jun 24]; Available from: https://www.sciencedirect.com/science/article/pii/S0043135411006282'},{id:"B33",body:'Chockalingam E, Chemosphere SS-, 2006 undefined. Studies on removal of metal ions and sulphate reduction using rice husk and Desulfotomaculum nigrificans with reference to remediation of acid mine. Elsevier [Internet]. [cited 2021 Jun 24]; Available from: https://www.sciencedirect.com/science/article/pii/S0045653505007162'},{id:"B34",body:'Bogush AA, Voronin VG. Application of a peat-humic agent for treatment of acid mine drainage. Mine Water Environ. 2011 Sep;30(3):185–190.'},{id:"B35",body:'El-Awady MH, Sami TM. Removal of heavy metals by cement kiln dust. Bull Environ Contam Toxicol. 1997 Oct;59(4):603–610.'},{id:"B36",body:'Erol M, Küçükbayrak S, Ersoy-Meriçboyu A, Ulubaş T. Removal of Cu2+ and Pb2+ in aqueous solutions by fly ash. Energy Convers Manag. 2005 May;46(7–8):1319–1331.'},{id:"B37",body:'Mackie AL, Walsh ME. Bench-scale study of active mine water treatment using cement kiln dust (CKD) as a neutralization agent. Water Res. 2012 Feb;46(2):327–334.'},{id:"B38",body:'Muliwa AM, Leswifi TY, Onyango MS. Performance evaluation of eggshell waste material for remediation of acid mine drainage from coal dump leachate. Miner Eng. 2018 Jun;122:241–250.'},{id:"B39",body:'Ahmad R, Kumar R, Haseeb S. Adsorption of Cu2+ from aqueous solution onto iron oxide coated eggshell powder: Evaluation of equilibrium, isotherms, kinetics, and regeneration capacity. Arab J Chem. 2012 Jul;5(3):353–359.'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Satish Chandra Bhuyan",address:"satishbhuyan2015@gmail.com",affiliation:'
Department of Mining Engineering, National Institute of Technology, India
Department of Mining Engineering, National Institute of Technology, India
'}],corrections:null},book:{id:"11074",type:"book",title:"Water Quality",subtitle:"Factors and Impacts",fullTitle:"Water Quality - Factors and Impacts",slug:"water-quality-factors-and-impacts",publishedDate:"February 2nd 2022",bookSignature:"Daniel Dunea",coverURL:"https://cdn.intechopen.com/books/images_new/11074.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-548-3",printIsbn:"978-1-83969-547-6",pdfIsbn:"978-1-83969-549-0",isAvailableForWebshopOrdering:!0,editors:[{id:"180202",title:"Associate Prof.",name:"Daniel",middleName:null,surname:"Dunea",slug:"daniel-dunea",fullName:"Daniel Dunea"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"465884",title:"Dr.",name:"Md. Samim",middleName:null,surname:"Al Azad",email:"dummy+141321254235241342342346983@intechopen.com",fullName:"Md. Samim Al Azad",slug:"md.-samim-al-azad",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"80058",title:"Evolution of Industry 4.0 and Its Implications for International Business",slug:"evolution-of-industry-4-0-and-its-implications-for-international-business",abstract:"Industry 4.0 is the natural consequence of the techno-industrial development of the last decades. It has the huge potentiality to change the way globalization of manufacturing and consumption of goods and services that take place in the global markets. This chapter will focus on the evolution of Industry 4.0 and how this new technological framework will create values for firms and consumers, and how we can use it for a firm’s competitiveness and save them from the fallout of its development. An extensive literature review shows that the multi-faceted technology will hugely impact the global value chain, global supply chain, and new global division of labor (NGDL). It will reconfigure and re-distribute the business activities in the developing, emerging, and developed country markets and small and medium sizes firms and MNCs. The rapid development of technological and human capabilities can allow firms to reap benefits from this technology. At the same time, there are many challenges related to skill shortages, technological issues, business ethics, and values that need to be overcome to reap a profit from this new technological advancement.",signatures:"Muhammad Mohiuddin, Md. Samim Al Azad, Selim Ahmed, Slimane Ed-Dafali and Mohammad Nurul Hasan Reza",authors:[{id:"418514",title:"Dr.",name:"Muhammad",surname:"Mohiuddin",fullName:"Muhammad Mohiuddin",slug:"muhammad-mohiuddin",email:"muhammad.mohiuddin@fsa.ulaval.ca"},{id:"465884",title:"Dr.",name:"Md. Samim",surname:"Al Azad",fullName:"Md. Samim Al Azad",slug:"md.-samim-al-azad",email:"dummy+141321254235241342342346983@intechopen.com"},{id:"465885",title:"Dr.",name:"Selim",surname:"Ahmed",fullName:"Selim Ahmed",slug:"selim-ahmed",email:"dummy+1413435212254235241342342346983@intechopen.com"},{id:"465886",title:"Dr.",name:"Slimane",surname:"Ed-Dafali",fullName:"Slimane Ed-Dafali",slug:"slimane-ed-dafali",email:"dummy+1413213512542352441342342346983@intechopen.com"},{id:"465887",title:"Dr.",name:"Mohammad",surname:"Nurul Hasan Reza",fullName:"Mohammad Nurul Hasan Reza",slug:"mohammad-nurul-hasan-reza",email:"dummy+141321543254237325241342342346983@intechopen.com"}],book:{id:"9544",title:"Global Trade in the Emerging Business Environment",slug:"global-trade-in-the-emerging-business-environment",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"323827",title:"Prof.",name:"Kiryl",surname:"Rudy",slug:"kiryl-rudy",fullName:"Kiryl Rudy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"328290",title:"Associate Prof.",name:"Gylych",surname:"Jelilov",slug:"gylych-jelilov",fullName:"Gylych Jelilov",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"333297",title:"Dr.",name:"Abdullahi",surname:"Ahmad Jibrin",slug:"abdullahi-ahmad-jibrin",fullName:"Abdullahi Ahmad Jibrin",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"333298",title:"Dr.",name:"Bilal",surname:"Celik",slug:"bilal-celik",fullName:"Bilal Celik",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"333299",title:"Dr.",name:"Abdurrahman",surname:"Isik",slug:"abdurrahman-isik",fullName:"Abdurrahman Isik",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"337511",title:"Assistant Prof.",name:"Edward",surname:"Asiedu",slug:"edward-asiedu",fullName:"Edward Asiedu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"338184",title:"Prof.",name:"Sung Jin",surname:"Kang",slug:"sung-jin-kang",fullName:"Sung Jin Kang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"341176",title:"Dr.",name:"Wenjia",surname:"Chang-Howe",slug:"wenjia-chang-howe",fullName:"Wenjia Chang-Howe",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"342691",title:"Associate Prof.",name:"Yanghua",surname:"Zhou",slug:"yanghua-zhou",fullName:"Yanghua Zhou",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"343951",title:"Dr.",name:"Seon Ju",surname:"Lee",slug:"seon-ju-lee",fullName:"Seon Ju Lee",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"open-access-funding",title:"Open Access Funding",intro:"
IntechOpen’s Academic Editors and Authors have received funding for their work through many well-known funders, including: the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, Chinese Academy of Sciences, Natural Science Foundation of China (NSFC), CGIAR Consortium of International Agricultural Research Centers, National Institute of Health (NIH), National Science Foundation (NSF), National Aeronautics and Space Administration (NASA), National Institute of Standards and Technology (NIST), German Research Foundation (DFG), Research Councils United Kingdom (RCUK), Oswaldo Cruz Foundation, Austrian Science Fund (FWF), Foundation for Science and Technology (FCT), Australian Research Council (ARC).
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\\n\\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\\n\\n
\\n\\t
Does your institution already have a budget for covering Open Access publication costs?
\\n\\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\\n
\\n\\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\\n\\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\\n\\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\n\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\n\n
\n\t
Does your institution already have a budget for covering Open Access publication costs?
\n\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\n
\n\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\n\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\n\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6601},{group:"region",caption:"Middle and South America",value:2,count:5906},{group:"region",caption:"Africa",value:3,count:2400},{group:"region",caption:"Asia",value:4,count:12541},{group:"region",caption:"Australia and Oceania",value:5,count:1008},{group:"region",caption:"Europe",value:6,count:17561}],offset:12,limit:12,total:132763},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"14"},books:[{type:"book",id:"11121",title:"Crystal Growth - Technologies and Applications",subtitle:null,isOpenForSubmission:!0,hash:"81f076fab2acb567946aeaa4b7281fc1",slug:null,bookSignature:"Dr. Riadh Marzouki",coverURL:"https://cdn.intechopen.com/books/images_new/11121.jpg",editedByType:null,editors:[{id:"300527",title:"Dr.",name:"Riadh",surname:"Marzouki",slug:"riadh-marzouki",fullName:"Riadh Marzouki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11466",title:"Titanium Alloys - Recent Progress in Design, Processing, Characterization, and Applications",subtitle:null,isOpenForSubmission:!0,hash:"1c89c2e1b5d03b90db5b13d44479baa6",slug:null,bookSignature:"Dr. Ram Krishna",coverURL:"https://cdn.intechopen.com/books/images_new/11466.jpg",editedByType:null,editors:[{id:"296477",title:"Dr.",name:"Ram",surname:"Krishna",slug:"ram-krishna",fullName:"Ram Krishna"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11467",title:"Bismuth-Based Nanostructured Materials",subtitle:null,isOpenForSubmission:!0,hash:"951c872d9d90e13cfe7d97c0af91845e",slug:null,bookSignature:"Dr. William Wilson Anku",coverURL:"https://cdn.intechopen.com/books/images_new/11467.jpg",editedByType:null,editors:[{id:"196465",title:"Dr.",name:"William Wilson",surname:"Anku",slug:"william-wilson-anku",fullName:"William Wilson Anku"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11468",title:"High Entropy Alloys - Recent Advances, New Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"3b4ef3ce01f8f9b113dc28ac847b8c0d",slug:null,bookSignature:"Prof. Yong A Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/11468.jpg",editedByType:null,editors:[{id:"203937",title:"Prof.",name:"Yong",surname:"Zhang",slug:"yong-zhang",fullName:"Yong Zhang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11470",title:"Graphene - Recent Advances, Future Perspective and Applied Applications",subtitle:null,isOpenForSubmission:!0,hash:"409e022e3baf48795e816576a6ee66e3",slug:null,bookSignature:"Dr. Mujtaba Ikram, Dr. Asghari Maqsood and Dr. Aneeqa Bashir",coverURL:"https://cdn.intechopen.com/books/images_new/11470.jpg",editedByType:null,editors:[{id:"286820",title:"Dr.",name:"Mujtaba",surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11471",title:"Advanced Cement-Based Materials",subtitle:null,isOpenForSubmission:!0,hash:"ade4b6eb27dabcb68870dd1d320840cd",slug:null,bookSignature:"Dr. Mohsen Mhadhbi",coverURL:"https://cdn.intechopen.com/books/images_new/11471.jpg",editedByType:null,editors:[{id:"228366",title:"Dr.",name:"Mohsen",surname:"Mhadhbi",slug:"mohsen-mhadhbi",fullName:"Mohsen Mhadhbi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11483",title:"Magnetic Materials - Recent Advances and Applications",subtitle:null,isOpenForSubmission:!0,hash:"9df995499c9e30ad3bc64368cde49ef4",slug:null,bookSignature:"Prof. Dipti Ranjan Sahu",coverURL:"https://cdn.intechopen.com/books/images_new/11483.jpg",editedByType:null,editors:[{id:"251855",title:"Prof.",name:"Dipti Ranjan",surname:"Sahu",slug:"dipti-ranjan-sahu",fullName:"Dipti Ranjan Sahu"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11484",title:"Thin Film Deposition - Fundamentals, Processes, and Applications",subtitle:null,isOpenForSubmission:!0,hash:"9c10a55203c2f0f7d47c743e6cfa2492",slug:null,bookSignature:"Dr. Dongfang Yang",coverURL:"https://cdn.intechopen.com/books/images_new/11484.jpg",editedByType:null,editors:[{id:"177814",title:"Dr.",name:"Dongfang",surname:"Yang",slug:"dongfang-yang",fullName:"Dongfang Yang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11485",title:"Wetting and Wettability - Fundamental and Applied Aspects",subtitle:null,isOpenForSubmission:!0,hash:"54b954378e0840f2317b2e94e6c467d6",slug:null,bookSignature:"Dr. Volodymyr Shatokha",coverURL:"https://cdn.intechopen.com/books/images_new/11485.jpg",editedByType:null,editors:[{id:"111000",title:"Dr.",name:"Volodymyr",surname:"Shatokha",slug:"volodymyr-shatokha",fullName:"Volodymyr Shatokha"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11758",title:"Glass-Ceramics - Recent Advances, New Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"e03ff7760e0aaea457f259ab63153846",slug:null,bookSignature:" Uday M. Basheer",coverURL:"https://cdn.intechopen.com/books/images_new/11758.jpg",editedByType:null,editors:[{id:"182041",title:null,name:"Uday",surname:"Basheer",slug:"uday-basheer",fullName:"Uday Basheer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11759",title:"Copper - From the Mineral to the Final Application",subtitle:null,isOpenForSubmission:!0,hash:"afea7aef1cb09fc3a1a5d619152d02a6",slug:null,bookSignature:"Dr. Daniel Fernández González and Dr. Luis Felipe Verdeja González",coverURL:"https://cdn.intechopen.com/books/images_new/11759.jpg",editedByType:null,editors:[{id:"211395",title:"Dr.",name:"Daniel",surname:"Fernández González",slug:"daniel-fernandez-gonzalez",fullName:"Daniel Fernández González"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11760",title:"Applications and Use of Diamond",subtitle:null,isOpenForSubmission:!0,hash:"2edcf9a24450d8655e756e1080defe32",slug:null,bookSignature:"Mr. Evgeniy Lipatov",coverURL:"https://cdn.intechopen.com/books/images_new/11760.jpg",editedByType:null,editors:[{id:"21254",title:"Mr.",name:"Evgeniy",surname:"Lipatov",slug:"evgeniy-lipatov",fullName:"Evgeniy Lipatov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:42},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:11},{group:"topic",caption:"Business, Management and Economics",value:7,count:5},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:19},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:62},{group:"topic",caption:"Environmental Sciences",value:12,count:9},{group:"topic",caption:"Immunology and Microbiology",value:13,count:10},{group:"topic",caption:"Materials Science",value:14,count:29},{group:"topic",caption:"Mathematics",value:15,count:10},{group:"topic",caption:"Medicine",value:16,count:122},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:12},{group:"topic",caption:"Psychology",value:21,count:9},{group:"topic",caption:"Robotics",value:22,count:4},{group:"topic",caption:"Social Sciences",value:23,count:8},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:3}],offset:12,limit:12,total:40},popularBooks:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4383},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3340,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1845,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1096,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:995,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3791,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:2982,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",publishedDate:"May 18th 2022",numberOfDownloads:559,editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",publishedDate:"May 18th 2022",numberOfDownloads:546,editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",publishedDate:"May 18th 2022",numberOfDownloads:539,editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",publishedDate:"May 18th 2022",numberOfDownloads:535,editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"332",title:"Melittology",slug:"entomology-melittology",parent:{id:"35",title:"Entomology",slug:"entomology"},numberOfBooks:3,numberOfSeries:0,numberOfAuthorsAndEditors:72,numberOfWosCitations:63,numberOfCrossrefCitations:46,numberOfDimensionsCitations:95,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"332",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"8929",title:"Modern Beekeeping",subtitle:"Bases for Sustainable Production",isOpenForSubmission:!1,hash:"cbf5aca68ed2c6690ad99f68aaaddcaf",slug:"modern-beekeeping-bases-for-sustainable-production",bookSignature:"Ramón Eduardo Rebolledo Ranz",coverURL:"https://cdn.intechopen.com/books/images_new/8929.jpg",editedByType:"Edited by",editors:[{id:"193813",title:"Dr.",name:"Ramón Eduardo",middleName:null,surname:"Rebolledo Ranz",slug:"ramon-eduardo-rebolledo-ranz",fullName:"Ramón Eduardo Rebolledo Ranz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7561",title:"Beekeeping",subtitle:"New Challenges",isOpenForSubmission:!1,hash:"1c47c831256fe10ff19fb10f490930fc",slug:"beekeeping-new-challenges",bookSignature:"Ramón Eduardo Rebolledo Ranz",coverURL:"https://cdn.intechopen.com/books/images_new/7561.jpg",editedByType:"Edited by",editors:[{id:"193813",title:"Dr.",name:"Ramón Eduardo",middleName:null,surname:"Rebolledo Ranz",slug:"ramon-eduardo-rebolledo-ranz",fullName:"Ramón Eduardo Rebolledo Ranz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5163",title:"Beekeeping and Bee Conservation",subtitle:"Advances in Research",isOpenForSubmission:!1,hash:"fc469ff4d2cf6651cfdbf3c5cf90a469",slug:"beekeeping-and-bee-conservation-advances-in-research",bookSignature:"Emerson Dechechi Chambo",coverURL:"https://cdn.intechopen.com/books/images_new/5163.jpg",editedByType:"Edited by",editors:[{id:"94059",title:"Dr.",name:"Emerson",middleName:"Dechechi",surname:"Dechechi Chambó",slug:"emerson-dechechi-chambo",fullName:"Emerson Dechechi Chambó"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:3,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"50073",doi:"10.5772/62487",title:"Impacts of Pesticides on Honey Bees",slug:"impacts-of-pesticides-on-honey-bees",totalDownloads:3325,totalCrossrefCites:17,totalDimensionsCites:38,abstract:"This chapter focuses on the detrimental effects that pesticides have on managed honey bee colonies and their productivity. We examine first the routes of exposure of bees to agrochemicals used for crop protection and their application to crops, fate and contamination of water and plants around the fields. Most of the time, the exposure of bees to pesticides is through ingestion of residues found in the pollen and nectar of plants and in water. Honey bees are also exposed to pesticides used for the treatment of Varroa and other parasites. The basic concepts about the toxicity of the different kinds of pesticides are explained next. Various degrees of toxicity are found among agrochemicals, and emphasis is given to the classic tenet of toxicology, “the dose makes the poison,” and its modern version “the dose and the time of exposure makes the poison.” These two factors, dose and time, help us understand the severity of the impacts that pesticides may have on bees and their risk, which are analysed in the third section. Sublethal effects are also considered. The final section is devoted to some practical advice for avoiding adverse impacts of pesticides in beekeeping.",book:{id:"5163",slug:"beekeeping-and-bee-conservation-advances-in-research",title:"Beekeeping and Bee Conservation",fullTitle:"Beekeeping and Bee Conservation - Advances in Research"},signatures:"Francisco Sanchez-Bayo and Koichi Goka",authors:[{id:"74970",title:"Dr.",name:"Francisco",middleName:null,surname:"Sánchez-Bayo",slug:"francisco-sanchez-bayo",fullName:"Francisco Sánchez-Bayo"},{id:"192045",title:"Dr.",name:"Koichi",middleName:null,surname:"Goka",slug:"koichi-goka",fullName:"Koichi Goka"}]},{id:"50307",doi:"10.5772/62654",title:"From Extraction to Meliponiculture: A Case Study of the Management of Stingless Bees in the West-Central Region of Mexico",slug:"from-extraction-to-meliponiculture-a-case-study-of-the-management-of-stingless-bees-in-the-west-cent",totalDownloads:2720,totalCrossrefCites:5,totalDimensionsCites:9,abstract:"Currently, stingless bees' populations are declining due to environmental degradation. In this context, the authors have developed a research project in the central-western region of Mexico with the goal to generate strategies for conservation and sustainable management of stingless bees. The chapter aims to present the process of this investigation and its main results in terms of a) local knowledge and management strategies of stingless bees, and b) the social process of technological appropriation of meliponiculture by beekeepers. We recognized specific knowledge on the biology and ecology of stingless bees that result in a system for identifying species and management strategies of wild populations of these bees based on the extraction of nests. The implementation of an innovative productive activity based on the principles of meliponiculture and current techniques has been well received by producers, which has led to the formation of the Meliponicultores Michoacanos del Balsas Association, which grows five species of stingless bees. The research suggests that conservation associated with the use of bees (integral meliponiculture) can be enhanced in the region. Faced with the loss of biodiversity and environmental crisis, it is essential to maintain and enhance local knowledge of stingless bees and management practices. This represents an alternative to develop management schemes that allow the raising and breeding of these bees, while its products are obtained.",book:{id:"5163",slug:"beekeeping-and-bee-conservation-advances-in-research",title:"Beekeeping and Bee Conservation",fullTitle:"Beekeeping and Bee Conservation - Advances in Research"},signatures:"Alejandro Reyes-González, Andrés Camou-Guerrero and Salvador\nGómez-Arreola",authors:[{id:"179951",title:"Dr.",name:"Andres",middleName:null,surname:"Camou-Guerrero",slug:"andres-camou-guerrero",fullName:"Andres Camou-Guerrero"},{id:"185413",title:"MSc.",name:"Alejandro",middleName:null,surname:"Reyes-González",slug:"alejandro-reyes-gonzalez",fullName:"Alejandro Reyes-González"},{id:"192049",title:"Dr.",name:"Salvador",middleName:null,surname:"Gómez-Arreola",slug:"salvador-gomez-arreola",fullName:"Salvador Gómez-Arreola"}]},{id:"50683",doi:"10.5772/63145",title:"Advances in Pharmacological Activities and Chemical Composition of Propolis Produced in Americas",slug:"advances-in-pharmacological-activities-and-chemical-composition-of-propolis-produced-in-americas",totalDownloads:2534,totalCrossrefCites:2,totalDimensionsCites:8,abstract:"Propolis is a resinous material produced by bees from the selective collection of plant exudates that are subsequently mixed with beeswax and salivary bee secretions. Propolis has been used in folk medicine, and certainly, several studies have validated its biological properties. The chemical composition and pharmacological activities of propolis collected through North (including Central America and Caribbean) and South America have been studied in the last years, and several papers have reported differences and similarities among the analysed geographical samples. Propolis has been classified according to its aspect and plant source; however, the ecological diversity present along the Americas provides a plethora of botanical resins. Herein, we summarize and discuss most of the studies performed at present on this profitable product for apiculture, attempting to compare the bioactivity, phytochemical diversity and botanical sources of honeybee propolis produced in Americas.",book:{id:"5163",slug:"beekeeping-and-bee-conservation-advances-in-research",title:"Beekeeping and Bee Conservation",fullTitle:"Beekeeping and Bee Conservation - Advances in Research"},signatures:"Efrain Alday, Moisés Navarro-Navarro, Adriana Garibay-Escobar,\nRamón Robles-Zepeda, Javier Hernandez and Carlos Velazquez",authors:[{id:"96966",title:"MSc.",name:"Moises",middleName:null,surname:"Navarro-Navarro",slug:"moises-navarro-navarro",fullName:"Moises Navarro-Navarro"},{id:"180409",title:"Dr.",name:"Carlos",middleName:null,surname:"Velazquez",slug:"carlos-velazquez",fullName:"Carlos Velazquez"},{id:"186351",title:"Dr.",name:"Ramón",middleName:null,surname:"Robles-Zepeda",slug:"ramon-robles-zepeda",fullName:"Ramón Robles-Zepeda"},{id:"186352",title:"MSc.",name:"Efrain",middleName:null,surname:"Alday",slug:"efrain-alday",fullName:"Efrain Alday"},{id:"186353",title:"Dr.",name:"Javier",middleName:null,surname:"Hernandez",slug:"javier-hernandez",fullName:"Javier Hernandez"},{id:"189161",title:"Dr.",name:"Adriana",middleName:null,surname:"Garibay-Escobar",slug:"adriana-garibay-escobar",fullName:"Adriana Garibay-Escobar"}]},{id:"50170",doi:"10.5772/62395",title:"A Comprehensive Characterization of the Honeybees in Siberia (Russia)",slug:"a-comprehensive-characterization-of-the-honeybees-in-siberia-russia-",totalDownloads:2256,totalCrossrefCites:4,totalDimensionsCites:8,abstract:"A comprehensive study of some populations of honeybee (332 colonies) in Siberia (Tomsk region, Krasnoyarsk Krai (Yenisei population), Altai) using morphometric and molecular genetic methods was conducted. Infestation of bees (132 colonies) by Nosema has also been studied. Three variants of the COI-COII mtDNA locus were registered: PQQ, PQQQ (typical for Apis m. mellifera), and Q (specific for southern races). It was established that 64% of bee colonies from the Tomsk region and all colonies studied from the Krasnoyarsk and the Altai territories originate from Apis m. mellifera on the maternal line. According to the morphometric study, the majority of bee colonies of the Tomsk region are hybrids; in some colonies the mismatch of morphometric and mtDNA data was observed. Moreover, the majority of bee colonies infected by Nosema were hybrids. Yenisei population may be considered as a unique Apis m. mellifera population. Microsatellite analysis (loci А008, Ap049, AC117, AC216, Ap243, H110, A024, A113) showed the specific distribution of genotypes and alleles for some loci in the bees, which differ by geographical location. Loci A024 and Ap049 are of considerable interest for further study as candidate markers for differentiation of subspecies; locus A008 can be considered informative for determining of different ecotypes of Apis m. mellifera.",book:{id:"5163",slug:"beekeeping-and-bee-conservation-advances-in-research",title:"Beekeeping and Bee Conservation",fullTitle:"Beekeeping and Bee Conservation - Advances in Research"},signatures:"Nadezhda V. Ostroverkhova, Olga L. Konusova, Aksana N. Kucher\nand Igor V. Sharakhov",authors:[{id:"180112",title:"Ph.D.",name:"Nadezhda",middleName:null,surname:"Ostroverkhova",slug:"nadezhda-ostroverkhova",fullName:"Nadezhda Ostroverkhova"},{id:"180249",title:"Ms.",name:"Olga",middleName:null,surname:"Konusova",slug:"olga-konusova",fullName:"Olga Konusova"},{id:"180342",title:"Prof.",name:"Aksana",middleName:null,surname:"Kucher",slug:"aksana-kucher",fullName:"Aksana Kucher"},{id:"180343",title:"Prof.",name:"Igor",middleName:null,surname:"Sharakhov",slug:"igor-sharakhov",fullName:"Igor Sharakhov"}]},{id:"71161",doi:"10.5772/intechopen.91196",title:"Detailed Review on Pesticidal Toxicity to Honey Bees and Its Management",slug:"detailed-review-on-pesticidal-toxicity-to-honey-bees-and-its-management",totalDownloads:1010,totalCrossrefCites:1,totalDimensionsCites:6,abstract:"This chapter deals with the effects of different pesticides used in agro-ecosystem on honey bees and other pollinators and probable measures to manage this escalating problem of global decline of managed as well as the wild insect pollinators. This chapter describes different routes from which pollinators, especially honey bees get exposed to the different toxicants, followed by poisoning symptoms in honey bees. Further, this chapter focuses on the classification of different toxicants in different classes as per their nature. Finally, the management of these different toxicants and their toxicity to avoid bee poisoning has been considered in the later portion of the chapter.",book:{id:"8929",slug:"modern-beekeeping-bases-for-sustainable-production",title:"Modern Beekeeping",fullTitle:"Modern Beekeeping - Bases for Sustainable Production"},signatures:"Gaurava Kumar, Swoyam Singh and Rukesh Pramod Kodigenahalli Nagarajaiah",authors:[{id:"305621",title:"Ph.D. Student",name:"Gaurava",middleName:null,surname:"Kumar",slug:"gaurava-kumar",fullName:"Gaurava Kumar"},{id:"315507",title:"Dr.",name:"Swoyam",middleName:null,surname:"Singh",slug:"swoyam-singh",fullName:"Swoyam Singh"},{id:"315508",title:"Dr.",name:"Rukesh",middleName:null,surname:"Pramod K.N.",slug:"rukesh-pramod-k.n.",fullName:"Rukesh Pramod K.N."}]}],mostDownloadedChaptersLast30Days:[{id:"50170",title:"A Comprehensive Characterization of the Honeybees in Siberia (Russia)",slug:"a-comprehensive-characterization-of-the-honeybees-in-siberia-russia-",totalDownloads:2254,totalCrossrefCites:4,totalDimensionsCites:8,abstract:"A comprehensive study of some populations of honeybee (332 colonies) in Siberia (Tomsk region, Krasnoyarsk Krai (Yenisei population), Altai) using morphometric and molecular genetic methods was conducted. Infestation of bees (132 colonies) by Nosema has also been studied. Three variants of the COI-COII mtDNA locus were registered: PQQ, PQQQ (typical for Apis m. mellifera), and Q (specific for southern races). It was established that 64% of bee colonies from the Tomsk region and all colonies studied from the Krasnoyarsk and the Altai territories originate from Apis m. mellifera on the maternal line. According to the morphometric study, the majority of bee colonies of the Tomsk region are hybrids; in some colonies the mismatch of morphometric and mtDNA data was observed. Moreover, the majority of bee colonies infected by Nosema were hybrids. Yenisei population may be considered as a unique Apis m. mellifera population. Microsatellite analysis (loci А008, Ap049, AC117, AC216, Ap243, H110, A024, A113) showed the specific distribution of genotypes and alleles for some loci in the bees, which differ by geographical location. Loci A024 and Ap049 are of considerable interest for further study as candidate markers for differentiation of subspecies; locus A008 can be considered informative for determining of different ecotypes of Apis m. mellifera.",book:{id:"5163",slug:"beekeeping-and-bee-conservation-advances-in-research",title:"Beekeeping and Bee Conservation",fullTitle:"Beekeeping and Bee Conservation - Advances in Research"},signatures:"Nadezhda V. Ostroverkhova, Olga L. Konusova, Aksana N. Kucher\nand Igor V. Sharakhov",authors:[{id:"180112",title:"Ph.D.",name:"Nadezhda",middleName:null,surname:"Ostroverkhova",slug:"nadezhda-ostroverkhova",fullName:"Nadezhda Ostroverkhova"},{id:"180249",title:"Ms.",name:"Olga",middleName:null,surname:"Konusova",slug:"olga-konusova",fullName:"Olga Konusova"},{id:"180342",title:"Prof.",name:"Aksana",middleName:null,surname:"Kucher",slug:"aksana-kucher",fullName:"Aksana Kucher"},{id:"180343",title:"Prof.",name:"Igor",middleName:null,surname:"Sharakhov",slug:"igor-sharakhov",fullName:"Igor Sharakhov"}]},{id:"70501",title:"Southeast Asian Meliponiculture for Sustainable Livelihood",slug:"southeast-asian-meliponiculture-for-sustainable-livelihood",totalDownloads:1204,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Stingless bees (Apidae: Meliponini) are one of the most important pollinators of native plants and economic crops in tropical and subtropical parts of the world. They not only establish large perennial colonies with complex social organization but also have a diverse nesting biology. The economic utilization of a total of 60 stingless bee species in Asia has been reported. The current status of meliponiculture in Southeast Asia is mainly focused on pollination utilization and honey and propolis production. This chapter shows that small-scale beekeeping of stingless bees, which is suitable for the flowering pattern in the tropics, is one of the best potential alternative opportunities. The cost-effectiveness analysis based on production yield, investment cost, and profit-return rate is reviewed. Finally, a sustainable utilization of stingless bees is considered to be an enhancer of pollination services both in an agricultural crop and natural ecosystem.",book:{id:"8929",slug:"modern-beekeeping-bases-for-sustainable-production",title:"Modern Beekeeping",fullTitle:"Modern Beekeeping - Bases for Sustainable Production"},signatures:"Atsalek Rattanawannee and Orawan Duangphakdee",authors:[{id:"283087",title:"Ph.D.",name:"Atsalek",middleName:null,surname:"Rattanawannee",slug:"atsalek-rattanawannee",fullName:"Atsalek Rattanawannee"},{id:"306411",title:"Dr.",name:"Orawan",middleName:null,surname:"Duangphakdee",slug:"orawan-duangphakdee",fullName:"Orawan Duangphakdee"}]},{id:"50073",title:"Impacts of Pesticides on Honey Bees",slug:"impacts-of-pesticides-on-honey-bees",totalDownloads:3304,totalCrossrefCites:17,totalDimensionsCites:37,abstract:"This chapter focuses on the detrimental effects that pesticides have on managed honey bee colonies and their productivity. We examine first the routes of exposure of bees to agrochemicals used for crop protection and their application to crops, fate and contamination of water and plants around the fields. Most of the time, the exposure of bees to pesticides is through ingestion of residues found in the pollen and nectar of plants and in water. Honey bees are also exposed to pesticides used for the treatment of Varroa and other parasites. The basic concepts about the toxicity of the different kinds of pesticides are explained next. Various degrees of toxicity are found among agrochemicals, and emphasis is given to the classic tenet of toxicology, “the dose makes the poison,” and its modern version “the dose and the time of exposure makes the poison.” These two factors, dose and time, help us understand the severity of the impacts that pesticides may have on bees and their risk, which are analysed in the third section. Sublethal effects are also considered. The final section is devoted to some practical advice for avoiding adverse impacts of pesticides in beekeeping.",book:{id:"5163",slug:"beekeeping-and-bee-conservation-advances-in-research",title:"Beekeeping and Bee Conservation",fullTitle:"Beekeeping and Bee Conservation - Advances in Research"},signatures:"Francisco Sanchez-Bayo and Koichi Goka",authors:[{id:"74970",title:"Dr.",name:"Francisco",middleName:null,surname:"Sánchez-Bayo",slug:"francisco-sanchez-bayo",fullName:"Francisco Sánchez-Bayo"},{id:"192045",title:"Dr.",name:"Koichi",middleName:null,surname:"Goka",slug:"koichi-goka",fullName:"Koichi Goka"}]},{id:"50135",title:"Breeding Program Design Principles for Royal Jelly",slug:"breeding-program-design-principles-for-royal-jelly",totalDownloads:2691,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This research was carried out to infer the genetic value to produce royal jelly in Africanized Apis mellifera L. honeybees with the compilation of data collected from 2006 to 2011. Genetic information of the selected and accessed colonies was obtained using the total DNA extraction techniques of nurse honeybees’ thorax with molecular markers for MRJP3 protein and characterized in Apis mellifera L. From the information on the colonies and genealogical structure were predicted genetic values of the colonies and queens for the larvae acceptance trait (%), royal jelly per colony (g), and royal jelly per cup (mg). Animal model with Bayesian Inference was used from Multiple Trait Gibbs Sampling software in Animal Models, Gibbs chains 58,500 cycles resulting from 650,000 cycles with intervals and disposal of 65,000 and 10 withdraw, respectively. From the predicted values, the colonies were classified into upper and lower. To compare the average of the genetic values according to the genotypes, the average multiple comparison tests were proceeded and implemented in routine PROC GENMOD from the Statistical Analysis System. Environmental effects were considered, time and hive type (standard Langstroth) as having flat distribution and collection as chi-square distribution. The studies presented an increase in the alleles C and D and the alleles D and E—referring to MRJPs—found in the highest genetic value for royal jelly production. Alleles D, E, and C are important when evaluating the parameters larvae acceptance, royal jelly per colony, and royal jelly per cup and, occasionally, it was the DE genotype that stood out royal jelly production. Genotypes DE, DC, and EC are those that should be kept in this evaluation system for royal jelly production, and the other genotypes should be discarded because they had the worst performance for the parameters evaluated.",book:{id:"5163",slug:"beekeeping-and-bee-conservation-advances-in-research",title:"Beekeeping and Bee Conservation",fullTitle:"Beekeeping and Bee Conservation - Advances in Research"},signatures:"Katia Ostrovski-Tomporoski, Patrícia Faquinello, Fabiana Martins\nCosta-Maia, Maria Claudia Ruvolo-Takasusuki, Pedro da Rosa\nSantos and Vagner Arnaut de Toledo",authors:[{id:"92329",title:"Dr.",name:"Vagner",middleName:"De Alencar",surname:"Arnaut De Toledo",slug:"vagner-arnaut-de-toledo",fullName:"Vagner Arnaut De Toledo"},{id:"119608",title:"Dr.",name:"Maria Claudia",middleName:"Colla",surname:"Ruvolo-Takasusuki",slug:"maria-claudia-ruvolo-takasusuki",fullName:"Maria Claudia Ruvolo-Takasusuki"},{id:"180234",title:"Dr.",name:"Patricia",middleName:null,surname:"Faquinello",slug:"patricia-faquinello",fullName:"Patricia Faquinello"},{id:"180235",title:"Prof.",name:"Fabiana",middleName:null,surname:"Costa-Maia",slug:"fabiana-costa-maia",fullName:"Fabiana Costa-Maia"},{id:"180368",title:"M.Sc.",name:"Katia",middleName:"Regina",surname:"Ostrovski-Tomporoski",slug:"katia-ostrovski-tomporoski",fullName:"Katia Ostrovski-Tomporoski"}]},{id:"50521",title:"Rearing Bumble Bees for Research and Profit: Practical and Ethical Considerations",slug:"rearing-bumble-bees-for-research-and-profit-practical-and-ethical-considerations",totalDownloads:2864,totalCrossrefCites:4,totalDimensionsCites:4,abstract:"The commercial production of bumble bee colonies is a multi-million dollar business worldwide. The pollination of greenhouse tomatoes is largely dependent on this industry. However, microparasites are prevalent in many of these colonies and can spread to wild populations of bumble bees. Academic researchers now commonly purchase colonies for their work. I believe that this raises some questions: (a) What is the danger of exacerbating the problem of spread of parasites and pathogens to wild population of bumble bees from field studies using purchased colonies? (b) How representative studies are done on only a few species, for example, B. terrestris, B. impatiens? (c) Does the purchase and use of these colonies give tacit approval to the industry, which may be having a detrimental effect on the native populations of bumble bees? This is an ethical issue. (d) Loss of “feeling for the organism” by researchers and particularly graduate students. These issues were discussed, and the classical method of bumble bee rearing which avoids these problems was described.",book:{id:"5163",slug:"beekeeping-and-bee-conservation-advances-in-research",title:"Beekeeping and Bee Conservation",fullTitle:"Beekeeping and Bee Conservation - Advances in Research"},signatures:"Robin E. Owen",authors:[{id:"101485",title:"Dr.",name:"Robin",middleName:"Edward",surname:"Owen",slug:"robin-owen",fullName:"Robin Owen"}]}],onlineFirstChaptersFilter:{topicId:"332",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"May 19th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"38",title:"Pollution",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",isOpenForSubmission:!0,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null},{id:"39",title:"Environmental Resilience and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",isOpenForSubmission:!0,editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",slug:"jose-navarro-pedreno",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",biography:"Full professor at University Miguel Hernández of Elche, Spain, previously working at the University of Alicante, Autonomous University of Madrid and Polytechnic University of Valencia. Graduate in Sciences (Chemist), graduate in Geography and History (Geography), master in Water Management, Treatment, master in Fertilizers and Environment and master in Environmental Management; Ph.D. in Environmental Sciences. His research is focused on soil-water and waste-environment relations, mainly on soil-water and soil-waste interactions under different management and waste reuse. His work is reflected in more than 230 communications presented in national and international conferences and congresses, 29 invited lectures from universities, associations and government agencies. Prof. Navarro-Pedreño is also a director of the Ph.D. Program Environment and Sustainability (2012-present) and a member of several societies among which are the Spanish Society of Soil Science, International Union of Soil Sciences, European Society for Soil Conservation, DessertNet and the Spanish Royal Society of Chemistry.",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null},{id:"40",title:"Ecosystems and Biodiversity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/40.jpg",isOpenForSubmission:!0,editor:{id:"209149",title:"Prof.",name:"Salustiano",middleName:null,surname:"Mato",slug:"salustiano-mato",fullName:"Salustiano Mato",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLREQA4/Profile_Picture_2022-03-31T10:23:50.png",biography:"Salustiano Mato de la Iglesia (Santiago de Compostela, 1960) is a doctor in biology from the University of Santiago and a Professor of zoology at the Department of Ecology and Animal Biology at the University of Vigo. He has developed his research activity in the fields of fauna and soil ecology, and in the treatment of organic waste, having been the founder and principal investigator of the Environmental Biotechnology Group of the University of Vigo.\r\nHis research activity in the field of Environmental Biotechnology has been focused on the development of novel organic waste treatment systems through composting. The result of this line of work are three invention patents and various scientific and technical publications in prestigious international journals.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorTwo:{id:"60498",title:"Prof.",name:"Josefina",middleName:null,surname:"Garrido",slug:"josefina-garrido",fullName:"Josefina Garrido",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRj1VQAS/Profile_Picture_2022-03-31T10:06:51.jpg",biography:"Josefina Garrido González (Paradela de Abeleda, Ourense 1959), is a doctor in biology from the University of León and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. She has focused her research activity on the taxonomy, fauna and ecology of aquatic beetles, in addition to other lines of research such as the conservation of biodiversity in freshwater ecosystems; conservation of protected areas (Red Natura 2000) and assessment of the effectiveness of wetlands as priority areas for the conservation of aquatic invertebrates; studies of water quality in freshwater ecosystems through biological indicators and physicochemical parameters; surveillance and research of vector arthropods and invasive alien species.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorThree:{id:"464288",title:"Dr.",name:"Francisco",middleName:null,surname:"Ramil",slug:"francisco-ramil",fullName:"Francisco Ramil",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003RI7lHQAT/Profile_Picture_2022-03-31T10:15:35.png",biography:"Fran Ramil Blanco (Porto de Espasante, A Coruña, 1960), is a doctor in biology from the University of Santiago de Compostela and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. His research activity is linked to the taxonomy, fauna and ecology of marine benthic invertebrates and especially the Cnidarian group. Since 2004, he has been part of the EcoAfrik project, aimed at the study, protection and conservation of biodiversity and benthic habitats in West Africa. He also participated in the study of vulnerable marine ecosystems associated with seamounts in the South Atlantic and is involved in training young African researchers in the field of marine research.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}}},{id:"41",title:"Water Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/41.jpg",isOpenForSubmission:!0,editor:{id:"349630",title:"Dr.",name:"Yizi",middleName:null,surname:"Shang",slug:"yizi-shang",fullName:"Yizi Shang",profilePictureURL:"https://mts.intechopen.com/storage/users/349630/images/system/349630.jpg",biography:"Prof. Dr. Yizi Shang is a pioneering researcher in hydrology and water resources who has devoted his research career to promoting the conservation and protection of water resources for sustainable development. He is presently associate editor of Water International (official journal of the International Water Resources Association). He was also invited to serve as an associate editor for special issues of the Journal of the American Water Resources Association. He has served as an editorial member for international journals such as Hydrology, Journal of Ecology & Natural Resources, and Hydro Science & Marine Engineering, among others. He has chaired or acted as a technical committee member for twenty-five international forums (conferences). Dr. Shang graduated from Tsinghua University, China, in 2010 with a Ph.D. in Engineering. Prior to that, he worked as a research fellow at Harvard University from 2008 to 2009. Dr. Shang serves as a senior research engineer at the China Institute of Water Resources and Hydropower Research (IWHR) and was awarded as a distinguished researcher at National Taiwan University in 2017.",institutionString:"China Institute of Water Resources and Hydropower Research",institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:0,paginationItems:[]},overviewPagePublishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"10843",title:"Persistent Organic Pollutants (POPs)",subtitle:"Monitoring, Impact and Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10843.jpg",slug:"persistent-organic-pollutants-pops-monitoring-impact-and-treatment",publishedDate:"April 13th 2022",editedByType:"Edited by",bookSignature:"Mohamed Nageeb Rashed",hash:"f5b1589f0a990b6114fef2dadc735dd9",volumeInSeries:1,fullTitle:"Persistent Organic Pollutants (POPs) - Monitoring, Impact and Treatment",editors:[{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",biography:"Prof. Mohamed Nageeb Rashed is Professor of Analytical and Environmental Chemistry and former vice-dean for environmental affairs, Faculty of Science, Aswan University, Egypt. He received his Ph.D. in Environmental Analytical Chemistry from Assiut University, Egypt, in 1989. His research interest is in analytical and environmental chemistry with special emphasis on: (1) monitoring and assessing biological trace elements and toxic metals in human blood, urine, water, crops, vegetables, and medicinal plants; (2) relationships between environmental heavy metals and human diseases; (3) uses of biological indicators for monitoring water pollution; (4) environmental chemistry of lakes, rivers, and well water; (5) water and wastewater treatment by adsorption and photocatalysis techniques; (6) soil and water pollution monitoring, control, and treatment; and (7) advanced oxidation treatment. Prof. Rashed has supervised several MSc and Ph.D. theses in the field of analytical and environmental chemistry. He served as an examiner for several Ph.D. theses in analytical chemistry in India, Kazakhstan, and Botswana. He has published about ninety scientific papers in peer-reviewed international journals and several papers in national and international conferences. He participated as an invited speaker at thirty international conferences. Prof. Rashed is the editor-in-chief and an editorial board member for several international journals in the fields of chemistry and environment. He is a member of several national and international societies. He received the Egyptian State Award for Environmental Research in 2001 and the Aswan University Merit Award for Basic Science in 2020. Prof. Rashed was recognized in Stanford University’s list of the World’s Top 2% Scientists in 2020 and 2021.",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11601",title:"Econometrics - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11601.jpg",hash:"bc8ab49e2cf436c217a49ca8c12a22eb",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 13th 2022",isOpenForSubmission:!0,editors:[{id:"452331",title:"Dr.",name:"Brian",surname:"Sloboda",slug:"brian-sloboda",fullName:"Brian Sloboda"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:19,paginationItems:[{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"79909",title:"Cryopreservation Methods and Frontiers in the Art of Freezing Life in Animal Models",doi:"10.5772/intechopen.101750",signatures:"Feda S. Aljaser",slug:"cryopreservation-methods-and-frontiers-in-the-art-of-freezing-life-in-animal-models",totalDownloads:170,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"79782",title:"Avian Reproduction",doi:"10.5772/intechopen.101185",signatures:"Kingsley Omogiade Idahor",slug:"avian-reproduction",totalDownloads:151,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Kingsley O.",surname:"Idahor"}],book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"78802",title:"Intraovarian Gestation in Viviparous Teleosts: Unique Type of Gestation among Vertebrates",doi:"10.5772/intechopen.100267",signatures:"Mari-Carmen Uribe, Gabino De la Rosa-Cruz, Adriana García-Alarcón and Juan Carlos Campuzano-Caballero",slug:"intraovarian-gestation-in-viviparous-teleosts-unique-type-of-gestation-among-vertebrates",totalDownloads:184,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"79209",title:"Virtual Physiology: A Tool for the 21st Century",doi:"10.5772/intechopen.99671",signatures:"Carmen Nóbrega, Maria Aires Pereira, Catarina Coelho, Isabel Brás, Ana Cristina Mega, Carla Santos, Fernando Esteves, Rita Cruz, Ana I. Faustino-Rocha, Paula A. Oliveira, João Mesquita and Helena Vala",slug:"virtual-physiology-a-tool-for-the-21st-century",totalDownloads:137,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78849",title:"Application of Vermicompost Fertilizer in Aquaculture Nutrition: Review",doi:"10.5772/intechopen.100326",signatures:"Sonnia Nzilani Musyoka and Rita Nairuti",slug:"application-of-vermicompost-fertilizer-in-aquaculture-nutrition-review",totalDownloads:67,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Nutrition - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11416.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"78617",title:"Doppler Ultrasound in the Reproduction of Mares",doi:"10.5772/intechopen.98951",signatures:"Camila Silva Costa Ferreira and Rita de Cássia Lima Morais",slug:"doppler-ultrasound-in-the-reproduction-of-mares",totalDownloads:123,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"78543",title:"Pulmonary Vein: Embryology, Anatomy, Function and Disease",doi:"10.5772/intechopen.100051",signatures:"Chan I-Ping and Hsueh Tung",slug:"pulmonary-vein-embryology-anatomy-function-and-disease",totalDownloads:171,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78564",title:"Anatomy of the Rhesus Monkey (Macaca mulatta): The Essentials for the Biomedical Researcher",doi:"10.5772/intechopen.99067",signatures:"Christophe Casteleyn and Jaco Bakker",slug:"anatomy-of-the-rhesus-monkey-macaca-mulatta-the-essentials-for-the-biomedical-researcher",totalDownloads:308,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}}]},subseriesFiltersForOFChapters:[{caption:"Animal Nutrition",value:20,count:1,group:"subseries"},{caption:"Animal Reproductive Biology and Technology",value:28,count:7,group:"subseries"},{caption:"Animal Science",value:19,count:11,group:"subseries"}],publishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"7102",title:"Pneumonia",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",slug:"pneumonia",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Nima Rezaei",hash:"9fd70142814192dcec58a176749f1b60",volumeInSeries:13,fullTitle:"Pneumonia",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9615",title:"Chikungunya Virus",subtitle:"A Growing Global Public Health Threat",coverURL:"https://cdn.intechopen.com/books/images_new/9615.jpg",slug:"chikungunya-virus-a-growing-global-public-health-threat",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Jean Engohang-Ndong",hash:"c960d94a63867dd12a8ab15176a3ff06",volumeInSeries:12,fullTitle:"Chikungunya Virus - A Growing Global Public Health Threat",editors:[{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",institutionString:"Kent State University",institution:{name:"Kent State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9619",title:"Epstein-Barr Virus",subtitle:"New Trends",coverURL:"https://cdn.intechopen.com/books/images_new/9619.jpg",slug:"epstein-barr-virus-new-trends",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Emmanuel Drouet",hash:"a2128c53becb6064589570cbe8d976f8",volumeInSeries:11,fullTitle:"Epstein-Barr Virus - New Trends",editors:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9525",title:"Insights Into Drug Resistance in Staphylococcus aureus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9525.jpg",slug:"insights-into-drug-resistance-in-staphylococcus-aureus",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Amjad Aqib",hash:"98bb6c1ddb067da67185c272f81c0a27",volumeInSeries:10,fullTitle:"Insights Into Drug Resistance in Staphylococcus aureus",editors:[{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9614",title:"Advances in Candida albicans",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9614.jpg",slug:"advances-in-candida-albicans",publishedDate:"November 17th 2021",editedByType:"Edited by",bookSignature:"Xinhui Wang",hash:"31d6882518ca749b12715266eed0a018",volumeInSeries:9,fullTitle:"Advances in Candida albicans",editors:[{id:"296531",title:"Dr.",name:"Xinhui",middleName:null,surname:"Wang",slug:"xinhui-wang",fullName:"Xinhui Wang",profilePictureURL:"https://mts.intechopen.com/storage/users/296531/images/system/296531.jpg",institutionString:"Qinghai Normal University",institution:{name:"University of Luxembourg",institutionURL:null,country:{name:"Luxembourg"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9528",title:"Current Topics and Emerging Issues in Malaria Elimination",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9528.jpg",slug:"current-topics-and-emerging-issues-in-malaria-elimination",publishedDate:"July 21st 2021",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"7f178329cc42e691efe226b32f14e2ea",volumeInSeries:8,fullTitle:"Current Topics and Emerging Issues in Malaria Elimination",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9613",title:"Dengue Fever in a One Health Perspective",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9613.jpg",slug:"dengue-fever-in-a-one-health-perspective",publishedDate:"October 28th 2020",editedByType:"Edited by",bookSignature:"Márcia Aparecida Sperança",hash:"77ecce8195c11092230b4156df6d83ff",volumeInSeries:7,fullTitle:"Dengue Fever in a One Health Perspective",editors:[{id:"176579",title:"Ph.D.",name:"Márcia Aparecida",middleName:null,surname:"Sperança",slug:"marcia-aparecida-speranca",fullName:"Márcia Aparecida Sperança",profilePictureURL:"https://mts.intechopen.com/storage/users/176579/images/system/176579.jpg",institutionString:"Federal University of ABC",institution:{name:"Universidade Federal do ABC",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7981",title:"Overview on Echinococcosis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7981.jpg",slug:"overview-on-echinococcosis",publishedDate:"April 22nd 2020",editedByType:"Edited by",bookSignature:"Fethi Derbel and Meriem Braiki",hash:"24dee9209f3fd6b7cd28f042da0076f0",volumeInSeries:6,fullTitle:"Overview on Echinococcosis",editors:[{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",institutionString:"Clinique les Oliviers",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7887",title:"Hepatitis B and C",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7887.jpg",slug:"hepatitis-b-and-c",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Luis Rodrigo",hash:"8dd6dab483cf505d83caddaeaf497f2c",volumeInSeries:5,fullTitle:"Hepatitis B and C",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",institutionString:"University of Oviedo",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}},{id:"351158",title:"Prof.",name:"David W.",middleName:null,surname:"Anderson",slug:"david-w.-anderson",fullName:"David W. Anderson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Calgary",country:{name:"Canada"}}}]}},subseries:{item:{id:"11",type:"subseries",title:"Cell Physiology",keywords:"Neurodevelopment and Neurodevelopmental Disease, Free Radicals, Tumor Metastasis, Antioxidants, Essential Fatty Acids, Melatonin, Lipid Peroxidation Products and Aging Physiology",scope:"
\r\n\tThe integration of tissues and organs throughout the mammalian body, as well as the expression, structure, and function of molecular and cellular components, is essential for modern physiology. The following concerns will be addressed in this Cell Physiology subject, which will consider all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and their interactions: (1) Neurodevelopment and Neurodevelopmental Disease (2) Free Radicals (3) Tumor Metastasis (4) Antioxidants (5) Essential Fatty Acids (6) Melatonin and (7) Lipid Peroxidation Products and Aging Physiology.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11407,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},publishedBooks:{paginationCount:8,paginationItems:[{type:"book",id:"7999",title:"Free Radical Medicine and Biology",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7999.jpg",slug:"free-radical-medicine-and-biology",publishedDate:"July 15th 2020",editedByType:"Edited by",bookSignature:"Kusal Das, Swastika Das, Mallanagouda Shivanagouda Biradar, Varaprasad Bobbarala and S. Subba Tata",hash:"083e5d427097d368a3f8a02bd6c76bf8",volumeInSeries:10,fullTitle:"Free Radical Medicine and Biology",editors:[{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8762",title:"Melatonin",subtitle:"The Hormone of Darkness and its Therapeutic Potential and Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/8762.jpg",slug:"melatonin-the-hormone-of-darkness-and-its-therapeutic-potential-and-perspectives",publishedDate:"June 24th 2020",editedByType:"Edited by",bookSignature:"Marilena Vlachou",hash:"bfbc5538173f11acb0f9549a85b70489",volumeInSeries:9,fullTitle:"Melatonin - The Hormone of Darkness and its Therapeutic Potential and Perspectives",editors:[{id:"246279",title:"Associate Prof.",name:"Marilena",middleName:null,surname:"Vlachou",slug:"marilena-vlachou",fullName:"Marilena Vlachou",profilePictureURL:"https://mts.intechopen.com/storage/users/246279/images/system/246279.jpg",institutionString:"National and Kapodistrian University of Athens",institution:{name:"National and Kapodistrian University of Athens",institutionURL:null,country:{name:"Greece"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8002",title:"Tumor Progression and Metastasis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8002.jpg",slug:"tumor-progression-and-metastasis",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Ahmed Lasfar and Karine Cohen-Solal",hash:"db17b0fe0a9b6e80ff02b81a93bafa4e",volumeInSeries:8,fullTitle:"Tumor Progression and Metastasis",editors:[{id:"32546",title:"Dr.",name:"Ahmed",middleName:null,surname:"Lasfar",slug:"ahmed-lasfar",fullName:"Ahmed Lasfar",profilePictureURL:"https://mts.intechopen.com/storage/users/32546/images/system/32546.png",institutionString:"Rutgers, The State University of New Jersey",institution:{name:"Rutgers, The State University of New Jersey",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6897",title:"Biophysical Chemistry",subtitle:"Advance Applications",coverURL:"https://cdn.intechopen.com/books/images_new/6897.jpg",slug:"biophysical-chemistry-advance-applications",publishedDate:"February 19th 2020",editedByType:"Edited by",bookSignature:"Mohammed A. A. Khalid",hash:"0ad18ab382e2ffb9ff202d15282297eb",volumeInSeries:7,fullTitle:"Biophysical Chemistry - Advance Applications",editors:[{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",institutionString:"Taif University",institution:{name:"Taif University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8008",title:"Antioxidants",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",slug:"antioxidants",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Emad Shalaby",hash:"76361b4061e830906267933c1c670027",volumeInSeries:5,fullTitle:"Antioxidants",editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",institutionString:"University of Pécs",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",slug:"calcium-and-signal-transduction",publishedDate:"October 24th 2018",editedByType:"Edited by",bookSignature:"John N. Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"4",title:"Fungal Infectious Diseases",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/465884",hash:"",query:{},params:{id:"465884"},fullPath:"/profiles/465884",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()