Toxic substances that can trigger seizures and their exerting mechanism.
\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5814",leadTitle:null,fullTitle:"Dental Anatomy",title:"Dental Anatomy",subtitle:null,reviewType:"peer-reviewed",abstract:'The book "Dental Anatomy" is one of the most important and basic areas of dentistry. This book is a collection of nine chapters divided into five sections as follows: \n
Mental disorders have been one of the leading contributors to the global disease burden in the twenty-first century. It has been accounted for one-third of the global disability [1]. Owing to the absence of cost-effective interventions and preventive measures, the prevalence of mental disorders shows no sign of declination. Surveys have shown that the increase in rates of treatments and therefore an even larger demand for mental health services has become an evitable problem for the society [2]. A proportion of patients with mental health problems shift from conventional health service to complementary and alternative medicine (CAM) [3]. Various studies showed the 12-month prevalence of CAM ranging from 10 to 75%, depending on populations and research methods [4]. Among all CAM applicable to patients, acupuncture, as one of the components in traditional Chinese medicine (TCM), has been commonly used in East Asian countries including China and Taiwan [5, 6]. In contrast to traditional body acupuncture, treatments for mental illness are more focused on acupuncture on the scalp. The sole use of acupoints or lines on the scalp in acupuncture deviates from the concept of traditional acupuncture and named scalp acupuncture. The development of scalp acupuncture has been rapid in the recent decades, and there is emerging evidence in supporting its use in patients with mental illnesses.
\nThe earliest medical record for the application of acupuncture on scalps can be traced back to around 5 BC [7]. Since then, experiences accumulated with the utilization of acupuncture on the scalp in treating various illnesses. Along with the establishment of TCM theories, it had been a component in traditional acupuncture system. Until the 1950s, acupuncture experts started to observe and recognize the relationship between illnesses and subscalp spots. Inspired by micropuncture systems concepts and influenced by anatomical and physiological knowledge from modern medicine, new theories and new needling techniques had been established [8]. In the 1970s, acupuncturists from different areas of China developed their own schools of theory, and several scalp acupuncture systems have been suggested. Despite variations present in theoretical concepts, sites of acupuncture (acupoints), and nomenclature among different schools, many areas such as the clinical indication and treatment procedures share common ground. Most recognized theories include the adaptation of knowledge in cerebral anatomy, physiology, neurology, and reflexology. Owing to the impressive therapeutic effect of scalp acupuncture in treating brain diseases as well as other illnesses, there was a strong urge to facilitate academic exchange and promote scalp acupuncture to wider communities. Intensive efforts had been made in standardizing the names of the scalp acupoints. By the time the World Health Organization (WHO) set up an international standard scalp acupuncture nomenclature systems in 1989, scalp acupuncture had been already extensively applied by therapists and acupuncturists around the globe [9]. Some places like the USA and Japan had even developed their own understandings in the field of scalp acupuncture [10, 11]. In short, scalp acupuncture is a technique derived from TCM, yet its theory and application involves multiplicity of systems that have been rapidly developing in the recent decades.
\nIn TCM concepts, all patients can be categorized into different syndrome types despite the diagnosis of disease. Patients will then be prescribed with a unique treatment regimen, i.e., two patients suffering from the same disease might receive prescription of different acupoints since they may vary in syndrome type [12]. This individualized medicine concept has been a feature of TCM since the early establishment of the philosophy of TCM. However, there are few shortcomings for this manipulation. Firstly, the differentiation of syndrome types may not be accurate or definite as the diagnosis procedures are highly dependent to the therapists’ clinical experience. Besides, since most patients with mental problems have complicated somatic problems or being masked by the side effects of psychiatric medication, diagnosis of syndrome type according to TCM theories may become exceptionally difficult. Moreover, individualized acupuncture treatment may provide inconsistent therapeutic outcomes. Objective observation and comparisons of the treatment results become impossible as the testing subjects are using different acupoints. As a result, we suggest the use of standardized, identical acupoint regimen for acupuncture treatment on psychiatric patients.
\nInstead of body acupuncture, scalp acupuncture has been widely used in diseases originated from the brain. The invention of scalp acupuncture has been with accordance to the neurology and reflexology knowledge of the brain and scalp structures. It is perceived that acupuncture stimulation on the subscalpular tissue may exert influences to the respective lesion in the brain [7]. A large proportion of preceding clinical trials of acupuncture on various mental illnesses such as anxiety, depression, and insomnia adopted the essential use of scalp acupuncture, while the collateral use of body acupuncture remains elective [13, 14, 15]. The sole use of scalp acupuncture in treating insomnia or other diseases such as intracerebral hemorrhage and Parkinson’s disease has been endorsed in literatures [15, 16, 17]. Therefore, we are convinced that the use of scalp acupuncture will be sufficient to bring about therapeutic value to the psychiatric patients.
\nBesides, scalp acupuncture shows superiority over body acupuncture in clinical situations. Unlike body acupuncture, patients receiving scalp acupuncture are not required to retain on bed. They can sit on chairs or carry out static activities during treatment sessions. Another advantage of scalp acupuncture is that since textile sensitivity of the scalp is relatively low, scalp acupuncture would cause less pain and discomfort when compared with body acupuncture. Apart from diminished unpleasant sensation during needle insertion, the manipulation of scalp acupuncture cannot be easily seen by the treatment recipients. This is important especially to those patients who easily feel anxious upon seeing needles.
\nIn practice of scalp acupuncture, sterile disposable acupuncture needles of the standard size of 0.20 × 25 mm or 0.22 × 25 mm are usually used. Acupuncture needles are obliquely inserted onto the selected acupoints with an angle of 15–30° after standard sterilization procedures. The needles should be inserted at a depth of 10 mm lying between aponeurosis layer and loose areolar connective tissue. Needles rest too deep or too shadow at the scalp structure will cause pain and diminished effect. After the insertion, mild stimulation to the needles is recommended. Needles can be swirled at time intervals. A standard session of scalp acupuncture treatment will last for at least an hour before the needles are carefully removed after the treatment.
\nAccording to TCM theories, acupoints are explicit points located at the surface of our bodies. Each acupoint serves its own function and can be joined together to form meridian lines. The selection and combination of acupoints is the most crucial component in acupuncture therapy. For example, it is understandable that the use of acupoints in treating brain diseases is definitely distinct from those for alleviating pain problems such as back pains. In the treatment of mental problems or brain organic problems, acupoints and scalp lines on the scalp including Baihui, Sishencong, midline of the forehead, lateral line 2 of the forehead and posterior lateral Line of the Vertex are commonly used.
\nBaihui is located at the vertex of the midline of the head, which is the meeting point from apexes of ears. It is one of the acupoints on the governor vessel (GV). The governor vessel is known to have its passage running from the coccyx upward along the spine into the brain. Under the TCM theory, it is the convergence of all Yang meridians and thus stimulation at Baihui can boost the flow of Qi in all the Yang meridians, benefits brain development, and enhances intelligence. In modern studies, Baihui has been comprehensively studied and applied in treating a variety of brain diseases and mood disorders such as intracerebral hemorrhage, dementia, depression, anxiety, insomnia, etc. [13, 18, 19, 20].
\nAround the site Baihui locates the acupoints Sishencong. Sishencong is the four points located at 1 cun anterior, posterior, and lateral to Baihui. They are excluded from the 12 main meridians. Sishencong is known for its calming effect as well as tranquilizing excitement in mood. Different directions of needle insertion at Sishencong, such as pointing toward or away from Baihui or toward the side of brain lesion, can bring about different therapeutic effects. In general, it facilitates the harmony of Yin and Yang.
\nThe location of the midline of forehead, also known as Shenting is 0.5 cun above the hairline and within the midline. Similar to Sishencong, it has been used to calm emotions and improve poor memory in theory. Lateral line 2 of the forehead are two acupoints located 0.5 cun above the hairline and directly above the pupils. In reference to anatomy, the midline and lateral line 2 of the forehand are the site of the prefrontal cortex (PFC). There are mainly five functions of PFC, which are executive functions, memory, intelligence, language, and gaze control. Because of the rich cortical and subcortical connection, PFC can initiate and perform goal-directed patterns of behavior, short-term memory tasks, planning, problem solving, etc. [21].
\nPosterior lateral lines of vertex are two points that are 1 cun next to the posterior Sishencong. It is located at posterior parietal lobe, anterior to the occipital lobe, and posterior to primary somatosensory cortex. Together with the close interconnection with frontal premotor area, it serves as a sensory-motor interface [22]. It receives sensory input from somatosensory cortex, and other regions of the brain integrate the information to allow the executive functioning.
\nAcupuncture for treating brain diseases is never mythical or ritual. It has originated from years of clinical experience and scientific proofs. Scalp acupuncture has proven to bring both functional and structural changes to the brain. Study has shown that scalp acupuncture at Sishencong can significantly decrease the heart rate and blood pressure of the test subjects. It is suggested that it exerts its effect through modulation of autonomic nervous system [23]. Another physiological change induced by scalp acupuncture is the regulation of perfusion in the brain. An alteration of perfusion among brain structures is detected under the inspection of single-photon emission computerized tomography (SPECT) [7, 24]. It is suggested to be the action of vasoconstrictor endothelin-1 (ET-1) [25]. The dysfunction of the brain structures in brain diseases and injuries can be detected and depicted by the probe of abnormal brainwaves [26]. Scalp acupuncture has shown its ability in restoring normal waveforms in healthy and depressed patients [27, 28]. In the long term, acupuncture provokes modulation at cortical structures including orbitofrontal cortex and prefrontal cortex and medial temporal lobes, together with limbic regions of hypothalamus, amygdala, cingulate, and hippocampus. The effects of acupuncture on these structures have been strongly supported by neuroimaging data obtained from electroencephalography (EEG), fMRI, magnetoencephalography (MEG), and positron emission tomography (PET) [29].
\nAltered catecholamine levels are commonly found in patients with mental illness. The use of scalp acupuncture has been suggest to bring about a surge of neurohormones and neurotransmitters in the central nervous system such as adrenocorticotropic hormone (ACTH), beta-endorphins, γ-aminobutyric acid (GABA) protein, noradrenaline, and serotonin [30, 31]. Other molecules such as brain-derived neurotrophic factor (BDNF), postsynaptic density-95 (PSD-95) protein, and nitric oxide synthase (NOS) also respond to scalp acupuncture, suggesting their possible participation to the mechanism of action [32, 33].
\nThere has been a long history of utilizing acupuncture in treating mental health problems and “mind-related” syndromes in ancient China. However, scientific literatures and clinical trials on acupuncture for mental problems had not been recorded until 1980s. Despite numerous clinical observations and controlled trials that have been made since then, evidences have remain insufficient to draw a definitive conclusion on the general use of acupuncture on psychiatric patients. More high-quality controlled trials with greater sample size and longer follow-up period are clearly needed in order to advocate the use of scalp acupuncture for treating mental illness.
\nDepression is the most common mental problem [34]. The disappointing response rate and side effects of conventional medication discourage a proportion of patients from complying conventional treatments. Instead, they turn to CAM treatments, including scalp acupuncture. Meta-analysis has shown possible efficacy of scalp acupuncture on major depressive and bipolar disorders and antepartum and post-stroke depressions [14, 35]. Several studies suggested that the effect of scalp acupuncture is comparable to conventional medication, while a study concluded better outcome in somatization and cognitive process disturbances over antidepressant [36]. Despite various clinical investigations that have been carried out, additional high-quality randomized controlled trials are urgently needed to provide conclusive evidence [37].
\nControlled studies have obtained consistent positive results on the use of acupuncture in patients suffering from anxiety disorder. However, most investigations have been focused on preoperative anxiety, generalized anxiety disorder, or anxiety neurosis only, while there is a large vacancy of knowledge about the effect of acupuncture on specific anxiety disorders like panic disorder, phobias, or obsessive-compulsive disorders [13]. A recent meta-analysis advocates the use of acupuncture on patients having post-traumatic stress disorder (PTSD) [38]. It is worth mentioning that a large proportion of studies concerning anxiety have been utilizing auricular acupuncture and body acupuncture, whereas investigations on the use of scalp acupuncture are scarce. We can see a great demand for complementing our knowledge toward the use of scalp acupuncture on various anxiety disorders.
\nRelatively few studies have been made on the use of scalp acupuncture to psychotic patients. Most studies suggested limited evidence on the use of acupuncture as adjuvant treatment along with antipsychotic medication. However, a general significant improvement in sleep quality and extrapyramidal side effects has been observed in psychotic patients receiving acupuncture treatment [35, 39].
\nInsomnia and sleep disorders are common mental health problems that have been always overlooked. Poor sleep quality could adversely affect the quality of life and deteriorate mental status. The use of acupuncture and scalp acupuncture may benefit insomnia patients, according to recent systematic review literatures. Since the current results of the clinical studies are promising and consistent, the use of acupuncture may be encouraged as an adjunctive therapy in insomnia [15]. We are expecting more high-quality evidence supporting especially the use of scalp acupuncture in the treatment of insomnia in the near future.
\nThe contraindications of scalp acupuncture include infants with unclosed cranial fontanelles and sutures. Patients with cranial infection, ulcer, or scars on scalp are not advised to perform scalp acupuncture. Patients with past history of epilepsy or seizure should be comprehensively evaluated by the therapists before receiving treatment. Patients extremely anxious toward needles should be handled with care. Appropriate counseling and encouragement will be useful in building a good rapport between therapist and the parent. Possible side effect of scalp acupuncture includes discomfort or mild pain by the needle, emotional distress during the treatment sessions, bleeding, sleep disturbance, and increased hyperactivity.
\nScalp acupuncture deserves greater concerns on its application on mental disorders. It has advantages over conventional individualized body acupuncture in clinical practice, and its effect could be objectively observed. Evidence from neuroimaging, biochemical investigations, and clinical trial has been supporting the use of scalp acupuncture on patients with mental disorders. We see great potential in scalp acupuncture to play an important role in alleviating or even preventing mental health problems in the future. Nonetheless, there is an urgent need for quality trials to provide definitive evidence to support the use of scalp acupuncture for various mental disorders.
\nCAM | complementary and alternative medicine |
ET-1 | endothelin-1 |
EEG | electroencephalography |
fMRI | functional magnetic resonance imaging |
GABA | γ-aminobutyric acid |
GV | governor vessel |
MEG | magnetoencephalography |
MRI | magnetic resonance imaging |
NOS | nitric oxide synthase |
PET | positron emission tomography |
PTSD | post-traumatic stress disorder |
PFC | prefrontal cortex |
PSD-95 | postsynaptic density-95 protein |
SPECT | single-photon emission computerized tomography |
TCM | traditional Chinese medicine |
WHO | World Health Organization |
The concept of toxicity refers to any substance capable of producing harm on livings organism. Hence, this chapter emphasizes on those compounds that harm the nervous system, particularly those capable of generating seizures. Within the pathophysiology of epilepsy, multiple mechanisms favor epileptogenesis, one of which is neurotoxicity. These excitotoxic mechanisms can exert their action through the glutamate receptors N-methyl-D-aspartate (NMDA); 𝜶-amino-2-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid (AMPA) and kainate, opening ionic channels permeable to calcium (Ca2+), sodium ions (Na+), that participate significantly in the neuronal damage derived from the excitotoxic effects. Though there are spontaneous inducers of epilepsy, different models that replicate seizures have been created to better understand the mechanisms underlying epileptic seizures. These models promote neurotoxicity in the brain and are triggered by certain substances, primarily agonists or antagonists of neurotransmitters involved in epileptic activity. In this review we aim to illustrate the neurotoxic potency of numerous agents administered in the brain with neurotoxic qualities, including medications used in clinical practice that can generate neurotoxicity.
Epileptic seizures, according to the World Health Organization, are defined as a neurological, chronic, recurrent, and repetitive condition of paroxysmal phenomena caused by an excessive abnormal discharge of groups of neurons, which can occur in different parts of the brain [1]. It is the result of synchronous electrical discharge from a group of hyper-excitable neurons, that when repeated consequently leads to neurotoxicity This hyperexcitability is due to an imbalance between the inhibitory processes given mainly by gamma-aminobutyric acid (GABA) and the excitatory ones of glutamate, which consequently modifies the function of ion channels regulated by Ca2+, Na+, and potassium (K+) mainly, which finally play a crucial role between the timing and propagation of abnormal discharges, contributing to the epileptic process [2]. Glutamate release activates NMDA ionotropic receptors, causing a rapid entry of Na+ and a slow entry of Ca2+. In epileptic seizures, with this massive entry of Ca2+, there is an increase of mitochondrial Ca2+ producing, among other effects an excitotoxic effect, in addition to free radicals production, proteases activation, and synthesis of nitric oxide which, by acting as a retrograde messenger, enhances the excitotoxic effect on the cell by also increasing glutamate release from the presynaptic terminals [3]. This glutamate release also activates the AMPA receptors associated with non-voltage-dependent channels, responsible for depolarizing currents, due to the Na+ input. AMPA receptor antagonists are known to have been shown to markedly reduce or decrease epileptic activity [4].
Kainic acid (KA) glutamate agonist acts on glutamatergic receptors with a high affinity for KA which is associated with a Na+ ion channel, this depolarization in turn causes Na+ channels opening, which leads to Ca2+ channels aperture that further increases neuron excitability. Na+ channels’ participation in epileptogenesis and their mutations in many epileptic disorders has been long studied. The Na
Activation of AMPA receptors, particularly NMDA receptors, triggers intracellular Ca2+ cascades. Ca2+ permeability studies indicate that there is also a low permeability of this ion through kainate receptors [10, 11]. Excessive Ca2+ intake, derived from a pathological condition such as epilepsy, contributes to an excitotoxic effect and subsequent neuronal death [12].
In epileptic seizures, glutamate elevation and GABA release are observed from the presynaptic terminals within the synaptic cleft. Astrocytes recapture these abnormally released neurotransmitters during the seizure, protecting neurons from excitotoxicity and eliminating excess glutamate. It is known that, derived from the epileptic processes, there is hypertrophy and significant changes in the ramifications and volume of the astrocyte soma. These changes undoubtedly impact the reuptake of neurotransmitters such as glutamate, allowing an excess of this in the synaptic space [13, 14].
It is worth noting that epilepsy research is so broad that despite not managing to control the neuropathology, some authors have claimed that studying the disease has allowed neuroscience to investigate more than just seizure disorders, but the brain regions not directly implicated in epilepsy, as well. This chapter, however, will concentrate only on epilepsy-related neurotoxicity.
When Ca2+ enters, it produces hyperexcitability in the excitable neuron through voltage-dependent Ca2+ channels (VDCCs). Intracellular processes are initiated when Ca2+ enters the cell, such as membrane excitability regulation, which permits neurotransmitters to be released. The biophysical and pharmacological properties of six types of Ca2+ channels (T, L, N, P, Q, and R) have been characterized. Low-threshold channels have been classed as T-type channels, while the rest have been classified as high-threshold channels. The number of depolarizations required for their activation has led to this classification. All channels have four subunits referred to as I through IV, each of which is made up of six transmembrane segments referred to as S1, S2, S3, S4, S5, and S6. The N, P and Q type channels are particularly crucial in controlling the release of neurotransmitters like glutamate and GABA, which, as previously stated, play a key role in epilepsy. The fact that a decrease in extracellular Ca2+ concentration can cause hyperexcitability in neurons is evidence that VDCCs play a major role in the epileptic activity [15]. In epilepsy, this correlates with paroxysmal depolarizations. Which correlates with paroxysmal depolarizations in epilepsy. This phenomenon has been observed in the hippocampus’s neurons and dendrites, particularly in the CA1 and CA3 neuroanatomical, critical regions in epileptic seizures. Ca2+ currents have been demonstrated to promote the development of epileptic seizures; this is thought to be due to an increase in postsynaptic responses triggered by excessive excitement, which then initiates an epileptic seizure. However, this type of activity also leads to neuronal death.
Epileptic activity can also be triggered by the input of extracellular Ca2+ into the neuron, which promotes neuronal membrane depolarization and action potential production, resulting in abnormal discharges and seizures. The rise in intracellular Ca2+ in the postsynaptic neuron has been linked to various factors that produce epileptogenesis, including persistent depolarization, inducing neurotoxicity. Animal models in mice (tottering, du-du, or stargazer) in which genes coding for Ca2+ channel subunits formation have been altered and made it possible to illustrate the role of Ca2+ in epileptogenesis, implying that channelopathies may be part of the substrate for abnormal activity. Because Ca2+ plays such a role in abnormal epileptic activity, drugs like ethosuximide have been developed to block T-type Ca2+ channels by reducing Ca2+ entry. Hence, neurotransmitter release is implicated in neuronal excitability [16, 17, 18, 19].
This chapter proposes several molecular signaling pathways that are involved in epileptogenesis. We described the most representative pathways in the epileptogenesis study. Until now, the complicated epileptogenesis pathophysiology and molecular processes that lead to seizures have remained a mystery. However, various anatomical pathways mechanisms, pathological pathways, and molecular interactions are known and have been explored based on the research available. Inhibitory and excitatory neurotransmission abnormalities have a big impact on neuron stability. Neuroinflammation and oxidative stress, for example, encourage the emergence of epileptic seizures and can potentially intensify them [20].
It has been claimed that the inflammatory state, and the elevation of its mediators, including IL-1ß, IL-6, high mobility group box TNF-α8, and cyclooxygenase-2. TNF-α produces endocytosis of GABA receptors through AMPA. Therefore, hyperexcitability in the hippocampus is boosted, resulting in seizures. Several studies have linked neuroinflammation to oxidative stress at the same time. The involvement of oxidative stress as a seizure generator is owing to an imbalance in the generation of reactive oxygen and nitrogen species, resulting in a deficiency in antioxidant mechanisms. The mitochondria are the body’s principal generator of oxygen radicals [21]. Other free radicals, including nicotinamide adenine dinucleotide phosphate oxidase and xanthine oxidase, have been shown to act through glutamate receptors. The activation of the NMDA receptor is linked to epileptic activity [22].
Another pathway described in the study of epileptogenesis is the
Notoginsenoside R1 (NGR1, was recently discovered to upregulate mRNA levels of the proteins β-catenin, Dvl, and Fzd, as well as promote the proliferation of cultured cortical neurons. NGR1 has also been discovered to reduce persistent K+ currents in hippocampus neurons, resulting in a reduced peak threshold. Treatment with a Wnt3a ligand, which activates the FZD receptor, caused K+ channel internalization and enhanced β-catenin expression, according to a recent study. GSK-3β inhibition caused by
In a previous study, a significant increase in β-catenin signaling in the cerebellar cortex of rats after kindling-induced generalized seizures was observed. β-catenin activation induces apoptosis through the expression of cMyc upregulation, a protein that negatively regulates anti-apoptotic proteins such as Bcl-2. This leads to a loss of mitochondria, membrane potential, releasing cytochrome-c and promoting activation of caspases 3 and 9, leading to neuronal death. The
Exposure to toxins can trigger seizures due to their damaging effect on the nervous system through different mechanisms (Table 1). The ability of organophosphate insecticides to induce epileptic seizures is known through the inhibition of acetylcholinesterase due to its chemical structure that contain the groups carbamoyl and thiocarbamoyl, due to its capacity to phosphorylate and inactivate acetylcholinesterase and in addition to stimulating cholinergic receptors, these pesticides include parathion, chlorpyrifos, aldicarb, and carbaryl. Certain toxins present a dual mechanism for epileptic seizures production through the facilitation of the activation and the inhibition of voltage-gated Na
Toxic substance | Mechanism |
---|---|
Parathion, chlorpyrifos, aldicarb, and carbaryl | Inhibiting acetylcholinesterase and hyperstimulation of cholinergic receptors |
Sarin, soman, scorpion venom and ciguatoxin | Modulating ion flow through voltage-gated sodium channels |
Anatoxin | Nicotinic receptor activation |
Kainic acid and domoic acid | Activation of glutamate receptors |
Lindane, picrotoxin and strychnine | GABA receptor inhibition |
Toxic substances that can trigger seizures and their exerting mechanism.
The administration of different drugs used therapeutically can predispose to epileptic seizures presence either by lowering the epileptogenic threshold, intoxication, or overdose of these. The main groups of antimicrobials that can cause seizures are beta-lactams, anti-tuberculous, and antimalarials. The pro epileptogenic effect of beta-lactams is related to high doses or their toxicity. Seizures related to drugs used to treat tuberculosis are mainly due to vitamin B6 deficiency. Mefloquine and chloroquine are reported antimalarial drugs that can lead to seizures. The proconvulsive effect of methylxanthines is thought to be due to A1 adenosine receptor inhibition. Paradoxically, it is known that carbamazepine can worsen generalized-onset seizures. As well as the withdrawal effect of benzodiazepines, which in some cases can lower the seizure threshold [30, 31, 32, 33, 34]. Table 2 summarizes the main drugs associated with seizures. The following part reviews some of the toxic effects of the main antiepileptic drugs used in clinical practice.
Category | Drugs associated with seizures |
---|---|
Sympathomimetics | Phenylephrine, pseudoephedrine, and anorexiants |
Analgesics | Opioids |
Anticancer drugs | Interferon alfa, methotrexate, mitoxantrone, nelarabine, platinum-based, cisplatin, vinblastine, vincristine, busulfan, chlorambucil, cytarabine, doxorubicin, etoposide, and fluorouracil |
Antimicrobials | Carbapenems, cephalosporins, fluoroquinolones, isoniazid, and penicillin |
Hypoglycemics | Any antidiabetic that causes hypoglycemia |
Immunosuppressants | Cyclosporine, mycophenolate, tacrolimus, and azathioprine |
Psychopharmaceuticals | Monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, serotonin modulators, tricyclic antidepressants, antipsychotics, atomoxetine, bupropion, buspirone, and lithium |
Stimulants | Amphetamines and methylphenidate |
Xanthine | Aminophylline and theophylline |
Antiepileptics | Carbamazepine and benzodiazepines |
Main drugs associated with drugs.
Since 1978, valproic acid or Na+ valproate has been characterized as an antiepileptic drug that suppresses the neuronal excitation of different types of epilepsy, such as partial seizures and generalized seizures [35]. It appears that valproic acid exerts its inhibition by blocking the reuptake of the neurotransmitter GABA, the main inhibitory neurotransmitter. It also lowers glutamate levels and modifies K+ conductance [36], exerting an inhibition through the voltage-dependent Na+ channels. In this way, it reduces the excitement caused by epileptic seizures [37]. Once this drug reaches the central nervous system (CNS), it binds to plasma proteins and is distributed throughout the extracellular space [38]. It is metabolized in the liver and discharged through the urine. Although it is also eliminated with expirations in the form of CO2 [39]. However, this drug is known to have frequent toxic effects derived from the therapeutic dose in patients with toxic plasma levels greater than 120 μg/ml [40]. After an overdose, the patient may be lethargic and coma, most likely due to inhibition produced in the CNS [41]. Another adverse situation that derives from the consumption of this antiepileptic drug is cerebral edema, probably caused by the overstimulation of the stimulation of NMDA receptors [42]. Cardiovascular alterations such as hypotension with tachycardia, gastric alterations such as pancreatitis, and hepatotoxicity have manifested with elevated transaminases, jaundice, and abdominal pain with inflammation, among others, may also occur [43].
Phenobarbital belongs to the family of barbiturates. These are characterized by providing the central nervous system with a depressant effect depending on the administered dose [44]. Its anticonvulsant mechanism is based on increasing the inhibitory activity of GABA, binding to the GABA receptor, and facilitating even more inhibitory neurotransmission. This inhibition reduces ATP levels, which causes the opening of Ca2+ channels associated with the NMDA receptor, coupled with the fact that a prolonged opening of these Ca2+ would lead to excitotoxic neuronal death [45]. The anticonvulsant dose ranges between 10 and 40 μg/ml. The administration of these doses and higher ones generates toxicity that is generally due to the increase in Ca2+ entry into the neuron [46]. Mitochondria are an intracellular target of barbiturates since they depolarize the mitochondrial membrane by inhibiting complex one of the electron transports chains and, furthermore, they could have an uncoupling effect on oxidative phosphorylation [47]. Its absorption of phenobarbital is gastric, which generates a decrease in peristaltic tone. Although it is metabolized in the liver and discharged through the kidneys and urine, it has a great fat solubility that crosses cell membranes, producing several alterations [48].
Carbamazepine is a mainly antiepileptic psychotropic drug whose mechanism of action is based on reducing glutamate release, reducing the permeability of neuronal membranes to Na+ and K+ ions, stabilizing neuronal membranes, and depressing dopamine and norepinephrine turnover, though an inhibitory effect on muscarinic and nicotinic receptors is also known [49]. When its therapeutic plasma concentrations are higher than 10 μg/ml, it produces toxic effects initially characterized by tachycardia, hypotension and hypertension, lethargy, ataxia, dysarthria, and nystagmus can occur, there are also gastric alterations such as vomiting and nausea. When intoxication is severe, it could even cause a coma [50]. Carbamazepine absorption is digestive, metabolized in the liver where it can cause liver dysfunction and, as its elimination is via the kidneys, adverse effects can also occur in this way [51].
Phenytoin has been the most commonly used antiepileptic drug for patients with focal and generalized epilepsies since 1938 [52]. Its mechanism of action is exerted by inactivating voltage-gated Na+ channels. It also acts by inhibiting the flow of Ca2+ through neuronal membranes, such as it is to be expected at the cardiac level, it also inhibits Na+ channels, which is why it has toxic effects on the myocardium [53]. Phenytoin is bound to plasma proteins, such as albumin, which is metabolized in the liver, so it can cause liver diseases. Toxic effects are present even if the patient has adequate therapeutic levels, like at concentrations lower than 20 mg/Kg [54, 55]. Among the clinical toxic effects, patients may present nystagmus, ataxia, and numbness [56]. With more severe intoxications, in addition to the above: dysarthria, ataxia, the patient might not be able to walk, and may present hyperreflexia, besides consciousness usually being inhibited [57]. With higher doses, patients may even display a coma [58].
Lamotrigine is an antiepileptic drug principally used for generalized and partial seizures; it is also used in the adjunctive treatment of refractory crises [59]. Its action mechanism at the cellular level is based on blocking excitatory neurotransmitters, especially glutamate, through its NMDA receptors, as well as inhibiting voltage-dependent Na+ currents [60]. The toxic effects on patients who take this drug above 600 mg are characterized primarily at the CNS level by difficulty in concentration, showing dysarthria, nystagmus, and blurred or double vision. Patients may even present a loss of balance or coordination [61]. Its absorption is intestinal, its elimination in the urine, metabolized in the liver. Thus, there is idiosyncratic hepatotoxicity that commonly requires liver transplantation [62].
Oxcarbazepine is a derivative of carbamazepine, approved as an antiepileptic drug in America in 2000 [63]. This drug is used in the treatment of any type of epileptic seizure. The cellular mechanism by which it exerts its antiepileptic effects is based on the fact that it blocks voltage-gated Na+ channels, modulates the activity of Ca2+ channels, and increases K+ conductance, which consequently produces a stabilization of hyperexcited neuronal membranes for epileptic seizures [64]. Oxcarbazepine is a drug that is metabolized like other antiepileptic drugs by the liver and excreted by the kidney [65]. Toxic effects when daily doses are above 30 mg/kg are basically characterized by gastric alterations: mainly nausea and vomiting. The alterations in the CNS are identified by headache, fatigue, drowsiness, and ataxia. It has also been reported that some patients may have vertigo and hyponatremia [66].
Ethosuximide is an anticonvulsant used to reduce the frequency of absence-type seizures. It exerts its mechanism by reducing Ca2+ currents antagonized by the T-type Ca2+ channels. Furthermore, linked to this drug, modulation of the function of voltage-activated Na+ channels and Na+/K+ dendritic hyperpolarization-activated cyclic nucleotide-gated channel 1 channels has been suggested. It also reduces neuronal excitability by inhibiting the Na+/K+ pump [67]. However, ethosuximide is almost entirely absorbed in the digestive tract and metabolized in the liver, which can cause liver disease. The toxic effects of patients who consume above 25 mg/kg comprise gastric issues, nausea, vomiting, constipation, a state of sedation, headache, decreased alertness, drowsiness, and even comas have been reported at the CNS level [68]. Other adverse effects may include weight loss, as well as leukopenia [69].
Gabapentin acts mainly by inhibiting partial and generalized seizures. Its mechanism of action is based on enhancing the inhibitory action of GABA [70]. A dose above 1,500 mg of gabapentin can cause hepatotoxicity, additionally, coupling various toxic effects like headaches, diplopia, nystagmus, diplopia, even involuntary movements have been described at the CNS level [71].
Topiramate is a drug used as an antiepileptic drug that acts by inhibiting partial and generalized seizures. Its action mechanism is exerted by blocking Na+ channels. As an AMPA receptor antagonist, it reduces excitatory neurotransmission, in addition to enhancing the inhibitory action of GABA [72]. Topiramate taken at a dose above 50 mg produces toxic effects, including dizziness. At the CNS level, patients have headaches, drowsiness, decreased concentration, and even confusion. Nevertheless, other anomalies have also been reported [73].
As noted, before the development of epilepsy, experimental models have been crucial in the further research of a neurological disorder affecting approximately 1% of the worldwide population. Some drugs cause structural and metabolic alterations in the nervous system as demonstrated by experimental epileptic models, culminating in seizure generation [74]. Antiepileptic drugs that are conventionally used in clinical practice have been successfully tested in many of these models, even though certain models have neurotoxic consequences, as we will discuss below.
With the aluminum model, focal seizures are studied by directly applying the substance to the cerebral cortex of the animal under study, where it has been observed that this substance generates dendritic loss, gliosis, loss of GABAergic neurons, and a decrease in glutamate decarboxylase [75, 76]. This model has been used to study antiepileptic drugs including diphenylhydantoin and pentobarbital, both of which have shown positive outcomes in reducing epileptic seizures frequency [77].
Focal seizures have been researched using cobalt powder, which has been applied to the research animal’s cortex or thalamus for epileptogenesis as part of the model development. This has reported GABA and glutamate decarboxylase enzyme production decreased, whereas neuronal death has been observed in the hippocampus. This cobalt model has also been suggested to interfere with Ca2+ signaling at NMDA glutamate receptors [78, 79, 80].
Similarly, using Zinc as an epilepsy model has been associated to neuronal death in the hippocampus, interference with GABAA receptors, and changes in the synapses of mossy fibers when there is a high concentration of this metal. It has also been observed to interfere with the responses of various receptors, including GABA, NMDA, and AMPA [81, 82]. While kainic acid, as an epileptic model, functions similarly to glutamate. The hippocampus is the most sensitive structure to this agent, with the highest number of receptors reported in the CA3 layer. This epilepsy model is used to examine focal seizures, with the hippocampus being the most sensitive structure to this substance. Changes in neuropeptide Y levels, hippocampus mossy fiber formation and a decrease in GABAB receptors are reported [83, 84, 85].
Pentylenetetrazol is used as an epileptic model to research generalized seizures. Shifts in the CA3 layer of the hippocampus, increased voltage in voltage-responsive K+ receptors, and interactions with GABAA and NMDA receptors have all been documented [86, 87]. The model has been shown to be suppressed by phenytoin and pentobarbital [88, 89]. Flurothyl gas, on the other hand, can cause status epilepticus in laboratory animals. Although this gas has long been utilized to investigate generalized seizures, the exact mechanism through which it causes seizures is yet uncertain. However, alterations in the lipidic membranes of hippocampus, amygdala, and cerebral cortex cells have been reported. A decrease in GABA synthesis and activation of the c-Fos gene have also been reported [90, 91, 92].
On the other hand, penicillin, like cobalt, has been utilized as a model for focal seizures in epilepsy research, causing myoclonic seizures. The loss of GABAergic neurons, neuronal death, and an increase in mossy fibers in the hippocampus are the key abnormalities seen in this model [93, 94, 95]. While bicuculline is classified as a GABA antagonist, it causes generalized seizures when used. Edema has been found in the astrocytes of the cerebral cortex, where it interacts with Ca2+ and K+ channels [96, 97]. Tetanus toxin has also been employed as a model of epilepsy because of its effect on seizure induction. There are interactions with inhibitory neurotransmission, synapse formation, exocytosis blocking, and a decrease in GABAergic signaling threshold with this substance [98, 99].
Additionally, pilocarpine affects the muscarinic acetylcholine receptors. The increase in activation of these receptors in the hippocampus characterizes its epileptogenic effect. In experimental animals, it can even cause status epilepticus. Significant damage to nervous system structures has been observed, particularly the entorhinal and piriform cortex, olfactory bulb, amygdala, hippocampus, and thalamus, as well as abnormalities in the function of Na+/K+ ATPase and NMDA receptors [100, 101, 102, 103].
The described above has enabled us to identify the excitotoxic effect induced by epileptic seizures, whether clinical or experimental. Likewise, it illustrated some of the toxic effects of antiepileptic drugs. From what has been illustrated, it is necessary to conduct research that allows offering other therapeutic alternatives to reduce the toxic effects of seizures and pharmacological therapy. The proposal of alternative treatments to treat seizures is essential to boost anti-toxic defense mechanisms. It can be suggested to propose therapies that minimize neuronal death or treatments with substances that activate antiepileptic protein activity, such as the extrinsic and intrinsic Glutamate receptors N-methyl-D-aspartate 𝜶-amino-2-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid Gamma-aminobutyric acid Calcium Sodium ions Potassium Central nervous system T-cell factor / lymphoid enhancing factor pathway Adenomatous polyposis coli protein Casein kinase 1 Glycogen synthase kinase 3 β Notoginsenoside R1 Notoginsenoside R1Appendices and nomenclature
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Today, the term “Systemic speech-and-language underdevelopment (SLU)” has firmly established in Russian science and practice, implying a complex developmental disorder of speech and language in children with a primary normal hearing and a conserved intellect, in which the main components of the language system are violated: vocabulary, grammar, phonetics, and, as a consequence, dialogic and monologic speech. Traditionally, a differentiated level-by-level analysis of the speech and language abilities of children is used. The variability of the manifestations and severity of speech-and-language disorders were initially systematized and characterized in four levels of underdevelopment: from the complete absence of phrase speech to the availability of simple and complex sentences with lexico-grammatical errors. Effective algorithms of speech therapist work with SLU are introduced. The effectiveness of the application of these models and algorithms on the material of various language groups is proved.",book:{id:"5957",slug:"advances-in-speech-language-pathology",title:"Advances in Speech-language Pathology",fullTitle:"Advances in Speech-language Pathology"},signatures:"Tatiana Tumanova and Tatiana Filicheva",authors:[{id:"204529",title:"Dr.",name:"Tatiana Volodarovna",middleName:null,surname:"Tumanova",slug:"tatiana-volodarovna-tumanova",fullName:"Tatiana Volodarovna Tumanova"},{id:"208704",title:"Dr.",name:"Tatiana Borisovna",middleName:null,surname:"Filicheva",slug:"tatiana-borisovna-filicheva",fullName:"Tatiana Borisovna Filicheva"}]},{id:"56560",doi:"10.5772/intechopen.70235",title:"The Role of Speech and Language Therapist in Autism Spectrum Disorders Intervention – An Inclusive Approach",slug:"the-role-of-speech-and-language-therapist-in-autism-spectrum-disorders-intervention-an-inclusive-app",totalDownloads:2293,totalCrossrefCites:2,totalDimensionsCites:16,abstract:"The chapter describes the possibilities of involving a speech-language therapist in the assessment of the pragmatic level of communication in autism spectrum disorders (ASD), where one of the most frequently impaired areas is communication pragmatics. These difficulties lead to a disruption of social interaction, which might be one of the obstacles to speech-language intervention in these children. The text is based on an originally developed testing material aimed at selected pragmatic-oriented communication situations relating to everyday activities and real life. Based on a comparison of domestic and international resources in this area, as well as mediated and own empirical experience, our assessment approach is based on the conclusion that pragmatics can be understood in different contexts and perspectives. The text presents the results of a partial survey comparing the performance of children with ASD and children with typical development. The assessment focused on the children’s election of the correct picture of a pair of pictures that represent usual communication and social situations. The results of the research suggest fewer incorrect responses in children with ASD and in different areas compared with children with typical development. However, the results of a qualitative analysis indicate a necessity to expand the assessment of communication pragmatics by adding an individually specific qualitative analysis of children’s performance.",book:{id:"5957",slug:"advances-in-speech-language-pathology",title:"Advances in Speech-language Pathology",fullTitle:"Advances in Speech-language Pathology"},signatures:"Kateřina Vitásková and Lucie Kytnarová",authors:[{id:"203061",title:"Associate Prof.",name:"Kateřina",middleName:null,surname:"Vitásková",slug:"katerina-vitaskova",fullName:"Kateřina Vitásková"},{id:"212035",title:"MSc.",name:"Lucie",middleName:null,surname:"Kytnarová",slug:"lucie-kytnarova",fullName:"Lucie Kytnarová"}]},{id:"36452",doi:"10.5772/38931",title:"Qualitative Research Methods in Psychology",slug:"qualitative-research-methods-in-psychology",totalDownloads:35810,totalCrossrefCites:12,totalDimensionsCites:16,abstract:null,book:{id:"1997",slug:"psychology-selected-papers",title:"Psychology",fullTitle:"Psychology - Selected Papers"},signatures:"Deborah Biggerstaff",authors:[{id:"123274",title:"Dr.",name:"Deborah",middleName:null,surname:"Biggerstaff",slug:"deborah-biggerstaff",fullName:"Deborah Biggerstaff"}]}],mostDownloadedChaptersLast30Days:[{id:"74550",title:"School Conflicts: Causes and Management Strategies in Classroom Relationships",slug:"school-conflicts-causes-and-management-strategies-in-classroom-relationships",totalDownloads:2098,totalCrossrefCites:1,totalDimensionsCites:10,abstract:"Conflicts cannot cease to exist, as they are intrinsic to human beings, forming an integral part of their moral and emotional growth. Likewise, they exist in all schools. The school is inserted in a space where the conflict manifests itself daily and assumes relevance, being the result of the multiple interpersonal relationships that occur in the school context. Thus, conflict is part of school life, which implies that teachers must have the skills to manage conflict constructively. Recognizing the diversity of school conflicts, this chapter aimed to present its causes, highlighting the main ones in the classroom, in the teacher-student relationship. It is important to conflict face and resolve it with skills to manage it properly and constructively, establishing cooperative relationships, and producing integrative solutions. Harmony and appreciation should coexist in a classroom environment and conflict should not interfere, negatively, in the teaching and learning process. This bibliography review underscore the need for during the teachers’ initial training the conflict management skills development.",book:{id:"7827",slug:null,title:"Interpersonal Relationships",fullTitle:"Interpersonal Relationships"},signatures:"Sabina Valente, Abílio Afonso Lourenço and Zsolt Németh",authors:null},{id:"73271",title:"Social Media and Its Effects on Beauty",slug:"social-media-and-its-effects-on-beauty",totalDownloads:2893,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Beauty is concerned with physical and mental health as both are intimately related. Short-term decisions to alter one’s body structure irrespective of genetic, environmental, occupational and nutritional needs can leave medium- and long-term effects. This chapter analyzes the role of social media and its effects on the standards of beauty. The researchers have summarized the literature on how social media plays a role in affecting beauty trends, body image and self-esteem concerns. There is support that social media affects individuals negatively, in pushing them to engage in life threatening beauty trends due to social compliance and acceptance in society. The aim was to review social networking sites’ impact on perception of standards of beauty and newer unrealistic trends gaining popularity that could alter opinions and also cause harm to individuals in the long run. This is an emerging area of research that is of high importance to the physical and mental health in the beauty, health and hospitality industry with the latter being manifested in depression, anxiety and fear of non-acceptability and being seen as a social gauche.",book:{id:"7811",slug:"beauty-cosmetic-science-cultural-issues-and-creative-developments",title:"Beauty",fullTitle:"Beauty - Cosmetic Science, Cultural Issues and Creative Developments"},signatures:"Mavis Henriques and Debasis Patnaik",authors:[{id:"320016",title:"Ph.D. Student",name:"Mavis",middleName:"Lilian",surname:"Henriques",slug:"mavis-henriques",fullName:"Mavis Henriques"},{id:"320978",title:"Dr.",name:"Debasis",middleName:null,surname:"Patnaik",slug:"debasis-patnaik",fullName:"Debasis Patnaik"}]},{id:"60564",title:"Ageing Process and Physiological Changes",slug:"ageing-process-and-physiological-changes",totalDownloads:6785,totalCrossrefCites:16,totalDimensionsCites:29,abstract:"Ageing is a natural process. Everyone must undergo this phase of life at his or her own time and pace. In the broader sense, ageing reflects all the changes taking place over the course of life. These changes start from birth—one grows, develops and attains maturity. To the young, ageing is exciting. Middle age is the time when people notice the age-related changes like greying of hair, wrinkled skin and a fair amount of physical decline. Even the healthiest, aesthetically fit cannot escape these changes. Slow and steady physical impairment and functional disability are noticed resulting in increased dependency in the period of old age. According to World Health Organization, ageing is a course of biological reality which starts at conception and ends with death. It has its own dynamics, much beyond human control. However, this process of ageing is also subject to the constructions by which each society makes sense of old age. In most of the developed countries, the age of 60 is considered equivalent to retirement age and it is said to be the beginning of old age. In this chapter, you understand the details of ageing processes and associated physiological changes.",book:{id:"6381",slug:"gerontology",title:"Gerontology",fullTitle:"Gerontology"},signatures:"Shilpa Amarya, Kalyani Singh and Manisha Sabharwal",authors:[{id:"226573",title:"Ph.D.",name:"Shilpa",middleName:null,surname:"Amarya",slug:"shilpa-amarya",fullName:"Shilpa Amarya"},{id:"226593",title:"Dr.",name:"Kalyani",middleName:null,surname:"Singh",slug:"kalyani-singh",fullName:"Kalyani Singh"},{id:"243264",title:"Dr.",name:"Manisha",middleName:null,surname:"Sabharwal",slug:"manisha-sabharwal",fullName:"Manisha Sabharwal"}]},{id:"27237",title:"Emotional Intelligence",slug:"emotional-intelligence",totalDownloads:5683,totalCrossrefCites:6,totalDimensionsCites:9,abstract:null,book:{id:"679",slug:"emotional-intelligence-new-perspectives-and-applications",title:"Emotional Intelligence",fullTitle:"Emotional Intelligence - New Perspectives and Applications"},signatures:"Adrian Furnham",authors:[{id:"85492",title:"Prof.",name:"Adrian",middleName:null,surname:"Furnham",slug:"adrian-furnham",fullName:"Adrian Furnham"}]},{id:"70731",title:"Theoretical Perspective of Traditional Counseling",slug:"theoretical-perspective-of-traditional-counseling",totalDownloads:1531,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter discusses the theoretical perspective of traditional counseling from an African context. Traditional counseling involves a broad perspective that enhances learning for transformation and integration of sociocultural values that are peculiar to each human society. A cursory review of the literature suggests that the concept of traditional counseling is rooted in traditional systems of knowledge and sociocultural customs and practices, and it promotes a collective approach to problem identification, resolution, and management. The traditional counseling process centers on four aspects: traditional counselor, client, family, and community. The key elements that inform the theoretical framework of traditional counseling from an African perspective are: cultural context, collective belief system, and initiation rituals Traditional systems of knowledge deemed essential for each generation are passed on successively to the next generation by elderly people who do not only have the necessary wisdom and experience, but are also adorned with social competences and skills.",book:{id:"9136",slug:"counseling-and-therapy",title:"Counseling and Therapy",fullTitle:"Counseling and Therapy"},signatures:"Hector Chiboola",authors:[{id:"314172",title:"Prof.",name:"Hector",middleName:null,surname:"Chiboola",slug:"hector-chiboola",fullName:"Hector Chiboola"}]}],onlineFirstChaptersFilter:{topicId:"21",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81882",title:"The Importance of Supporting Creativity Development as the Main Skill of the Twenty-First Century",slug:"the-importance-of-supporting-creativity-development-as-the-main-skill-of-the-twenty-first-century",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.104919",abstract:"This chapter calls into question the ways of creativity development as the main skill of the twenty-first century. Attention is paid to the analysis of key notions and concepts of creativity. This chapter discusses how to enhance creative thinking skills during training in higher institutions. The study presents the results gained from the literature overview. The examples of assignments aimed at creative thinking skills development during training are given. The paper investigates approaches to the construction of tasks to develop creative thinking and criteria for creativity assessment. An analysis has allowed highlighting the positive experience of different experts researched creativity, which can be implemented in future training in Ukrainian higher educational institutions. The findings of this study support the idea that heuristic tasks, creative projects, mind maps, and case study are significant assignments in the enhancement of creativity development that can be supported in the educational process and everyday life.",book:{id:"11303",title:"Creativity",coverURL:"https://cdn.intechopen.com/books/images_new/11303.jpg"},signatures:"Iryna Simkova, Kateryna Tuliakova, Oksana Serheieva and Oksana Pastushenko"},{id:"81771",title:"Psychotherapy in Nature: Exploring an Alternative Psychotherapeutic Framework to Address the Limitations of Working in Traditional Settings in Order to Move with the Times",slug:"psychotherapy-in-nature-exploring-an-alternative-psychotherapeutic-framework-to-address-the-limitati",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.104627",abstract:"This paper introduces nature therapy and single session therapy as alternative psychotherapeutic frameworks in addition to more traditional ways of working, offering a modern perspective on evolving societal and individual needs. In particular, the concern for human coping mechanisms and survival in today’s fast paced environment dictates a growing need to address conflicts of inner and outer lived experiences, dissociation, and trauma, where traditional settings are failing or inadequate. Ethical considerations and applications for working outside in nature are discussed, as well as limitations for traditional settings. This paper can be used as an introductory guide for practitioners seeking to work therapeutically in nature.",book:{id:"11305",title:"Counseling and Therapy - Recent Developments in Theories and Concepts",coverURL:"https://cdn.intechopen.com/books/images_new/11305.jpg"},signatures:"Philippa Williams"},{id:"81652",title:"Sexual Health Education for Youth with Disabilities: An Unmet Need",slug:"sexual-health-education-for-youth-with-disabilities-an-unmet-need",totalDownloads:22,totalDimensionsCites:0,doi:"10.5772/intechopen.104420",abstract:"Individuals with disabilities experience higher rates of mental, emotional, physical, and sexual abuse than those without disabilities. Children with disabilities are 3.4 times more likely to experience sexual abuse than their peers without disabilities. Although a variety of resources have been created to help improve the sexual health of people with disabilities, one area that is seriously lacking is access to sexual health information and education. Previous work has identified several barriers to providing sexual health education to adolescents and youth with disabilities, including lack of teacher preparation, lack of teacher knowledge that leads to fear, concern, and anxiety, parental anxiety and fear, the lack of valid and reliable sexual health education materials for students with disabilities, and the sexuality of students with disabilities viewed as deviant. This chapter will review those issues and discuss methods to improve sexual health education for youth with disabilities.",book:{id:"11267",title:"Human Sexuality",coverURL:"https://cdn.intechopen.com/books/images_new/11267.jpg"},signatures:"Shanon S. Taylor and Tammy V. Abernathy"},{id:"81634",title:"A Plea for Mixed Methods Research in the Field of Counseling",slug:"a-plea-for-mixed-methods-research-in-the-field-of-counseling",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.104781",abstract:"We need more research in counseling if we want to strengthen counseling as a profession and if we want to implement counseling in mental health systems. Thus, the research should be multiple dimensional. This chapter is a plea for mixed-methods research (MMR) designs in the field of counseling. Even if MMR is very elaborate, it is worth doing. By way of example, I would like to briefly outline three of my projects, using MMR. The first one is a mixed methods research study on the video-based counseling method Marte Meo. The second project is one concerning genograms. Genograms are an integral part of therapy and counseling. The third MMR project is an elaborate research project which we carry out on behalf of the “Deutsche Gesellschaft für Beratung”, the German National Association for Counseling (Member of the European Association for Counseling, EAC, and the International Association for Counseling, IAC) to develop a German qualifications framework for Counseling—in the context of the European Qualifications Framework (EQF). Finally, I refer to Guetterman et al. who provide some empirical evidence for researchers who wish to take full advantage of mixed methods to address pressing clinical and public health issues.",book:{id:"11305",title:"Counseling and Therapy - Recent Developments in Theories and Concepts",coverURL:"https://cdn.intechopen.com/books/images_new/11305.jpg"},signatures:"Dirk Rohr"},{id:"81633",title:"Use of Nonviolent Communication: Deepening Teacher–Student Interpersonal Relationships",slug:"use-of-nonviolent-communication-deepening-teacher-student-interpersonal-relationships",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.103797",abstract:"Human beings are social animals and communication between humans is an inevitable component of human life. In a formal school setup, the routine interpersonal interactions in classrooms form the building block of the teacher-student relationships. Strong healthy interpersonal relationships between students and teachers necessitate skills that revolve around the ability of both to create a positive educational setting encompassing conditions of empathy, warmth, mutual respect, amongst others. Teachers in the capacity of being far more experienced than students will need to exercise their agency with an exclusive set of behavioral actions and act as professionals with a different set of responsibilities in the best interest of their students. Daily talk and actions may reflect a kind of violence that can disrupt relationships creating unhealthy environment. Violence can be manifested in different forms of communication that inhibits autonomy, fails to recognize one’s and others’ needs, among others. Rosenberg emphasizes the importance of nonviolence in everyday life and brings out the essence of a good interpersonal relationship through non-violent communication (NVC). Within this context, the present chapter will explore ways of non-violent communication that can enable teachers to develop and nurture healthy positive interpersonal relationships with students.",book:{id:"11307",title:"Interpersonal Relationships",coverURL:"https://cdn.intechopen.com/books/images_new/11307.jpg"},signatures:"Gomathi Jatin Shah"},{id:"81619",title:"Interpersonal Trust within Social Media Applications: A Conceptual Literature Review",slug:"interpersonal-trust-within-social-media-applications-a-conceptual-literature-review",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.103931",abstract:"Interpersonal trust within social media applications is a highly discussed topic. The debate ranges from trusting the application, related to security and privacy, to trusting content and the underlying content delivery algorithms. Several trust-related phenomena have surfaced in recent years, known as filter bubbles, echo chambers and fake news. Addressing these phenomena is often pushed to either the regulator or directly to the provider of the social media application. Interpersonal trust within social media applications is a more complex topic and not limited to the application or the content, but has to include the behaviour of the user. To broaden the debate beyond the prevalent focus on the application and content this paper presents a conceptual literature review studying interpersonal trust within social media with the goal to deepen the understanding of the complex interplay between user behaviour in relation to interpersonal trust. Based on this review modalities of interpersonal trust are identified and presented. To extend on these findings an information-dense word embedding based analysis is presented by using unsupervised machine learning techniques.",book:{id:"10673",title:"The Psychology of Trust",coverURL:"https://cdn.intechopen.com/books/images_new/10673.jpg"},signatures:"Kevin Koidl and Kristina Kapanova"}],onlineFirstChaptersTotal:70},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],testimonialsList:[]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"May 13th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. She has over 160 Scientific Publications in International Journals and Conferences and she is the author of 5 books on Innovation and Decision Making in Industrial Applications and Engineering.",institutionString:null,institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",isOpenForSubmission:!0,editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",isOpenForSubmission:!0,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:'Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the "new normal". Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.',institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!1,editor:null,editorTwo:null,editorThree:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",isOpenForSubmission:!0,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. 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He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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