",isbn:"978-1-83969-558-2",printIsbn:"978-1-83969-557-5",pdfIsbn:"978-1-83969-559-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"97b6de623f15598880112f6bafedc3e1",bookSignature:"Dr. Robert M.X. Wu",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11916.jpg",keywords:"Business Models, E-commerce Marketing Strategy, E-commerce Business Models, Digital Transformation, Business Intelligence, E-business Applications, Research, Information System Management, Marketing Management, Electronic Commerce, Internet Marketing, Information Systems",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 26th 2022",dateEndSecondStepPublish:"May 24th 2022",dateEndThirdStepPublish:"July 23rd 2022",dateEndFourthStepPublish:"October 11th 2022",dateEndFifthStepPublish:"December 10th 2022",remainingDaysToSecondStep:"4 hours",secondStepPassed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:'Dr. Wu holds a Ph.D. in e-Commerce, lectures at the School of Engineering and Technology in Australia, and is a Distinguished Professor at Shanxi Normal University, China. 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1. Introduction
Anxiety is a natural emotion characterized by alertness, vegetative autonomous and behavioral responses, accompanied by subjective sensations, all important for surviving. In the long term, an overexposition to adverse stimuli may lead to a depression comorbid to anxiety. Usually, human beings facing a stressor develop a cognitive or perceptual evaluation comparing previous experiences to solve the threat through an action. Consequently to natural anxiety, a state of heightened attention occurs preparing the body to fight or run away from the perceived threat. This fight-or-flight anxiety response follows an inverted U-shape curve; there is an optimum quantity of anxiety that produces the best response to success. A high level of anxiety interferes with concentration and memory, which are critical for academic success. Without any anxiety, however, people would lack the motivation to study for exams, write papers, or do daily homework, among others. In addition, deficits in familiar relationships and social isolation alter physical and mental health in young students, which reduce their capacities at school. Adolescence is characterized by significant physiological, anatomical and psychological changes in boys and girls, who become vulnerable to psychiatric disorders. Disorders such as anxiety and depression affect scholar performance and students might not be appropriately attended. In this chapter we describe anxiety and depression focused on adolescents and reviewed approaches to the study of anxiety and depression symptoms related with the academic performance in adolescents and young guys. The research literature was based on PubMed and Google Advanced Scholar databases. Results from available published studies in academic journals are reviewed to discuss the importance to detect information about anxiety, depression, academic performance and further considerations.
2. Anxiety and depression
2.1. Concept
Anxiety is an adaptive response generated by environmental stressful situations that activate alarm mechanisms in the individual to assure survival. This emotion is a series of biochemical changes in the brain and body, which makes the heart to beat faster due to an increase in adrenaline, and feeling less pain due to a decrease in cerebral dopamine. However, if the state of anxiety is not adequately affronted or it is produced by an inexistent stimulus in the longterm, natural anxiety is now converted in an anxiety disorder. In this way, natural anxiety is beneficial for the individual but if the level of anxiety is exceeded, it deteriorates the habitual activity of the organism; in this case, higher anxiety produces a lower efficiency of the individual [1, 2]. In human beings, anxiety disorders are characterized by excessive fear and distress in the absence of real danger, that is to say, an excessive preoccupation, fatigue, problems of sleeping or concentrating, irritability, muscle tension, aggressive behavior, vulnerability sensation, surveillance exacerbation, and exaggerated emotional reactions to danger [3]. The anxiety symptoms reflect an excessive autonomic activity caused by the over-release of adrenaline, noradrenaline and cortisol, which in consequence produces perspiration, palpitations, rise in blood pressure, loss of sphincters control, development of gastric ulcers, among others. Anxiety and depressive disorders are classified in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR and recent DSM-5) and International Classification of Diseases (ICD-10), according to the duration, intensity and origin of symptoms. Anxiety is classified in some types of phobia, separation and social anxiety disorders, among others [3].
Anxiety disorders are influenced by environmental stimuli that are stressful for the individual. Antiquely, it was believed that anxiety disorders were learned, and although the familiar and social context influence in the possibility to develop an anxiety disorder, nowadays, it is known that anxiety disorders have a neurobiological substrate that involves neurochemical changes modifying the correct function of diverse brain structures [4]. In fact, they are the same brain structures involved in the etiology of depressive disorders, which explain the comorbidity among anxiety and depressive disorders, as well as the observation that some antidepressant drugs (i.e., selective serotonin reuptake inhibitors) produce also anxiolytic actions at the clinical level [3,5]
On the other hand, depression is an affective disorder identified from antique cultures around the world [6, 7]. Nowadays, it is considered as a psychiatric disorder classified in the DSM-5 [3]. Its prevalence and incidence have a marked sexual dimorphism; it is estimated that in the general population, it is 10–25% in women and 5–12% in men [8]. The morbidity and mortality associated with depressive disorders are higher and increasing continuously. Depression occupies the fourth place among principal causes of major incapacity around the world, occupying the first place before respiratory affections, perinatal problems, and HIV/AIDS (Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome) [9]. It is estimated that 17% of the population experiment any depressive episode during their lifespan, and those who suffer a chronic illness have a higher predisposition to develop depressive episodes with an incidence of 30-50% [10]. By 2020, it is estimated that major unipolar depression will be the second cause of incapacity of human beings around the world [11]. Depression is characterized by anhedonia (incapacity to experiment pleasure) as a central symptom but also includes episodes of irritability, anxiety and fear, in addition to alterations in appetite, body weight, sleep and motor efficiency—all accompanied by low self-esteem, guilt and the idea of death that predispose to suicide risk [3].
3. Anxiety and depression in adolescents
3.1. Anxiety
Affective disorders in young people may come from early stress exposition. For example, young adulthood with emotional distress disorders is associated with frequent and recurrent physical distress during childhood [12]. Human epidemiological and animal studies indicate that stressful experiences in utero or during early life may increase the risk of neurological and psychiatric disorders, arguably via altered epigenetic regulation [13]. In case of anxiety and depression disorders, the symptomatology could be quite different from adults.
Anxiety has been considered as a psychiatric disorder in childhood since the 1980s, and depression since the 1970s, always associated with the psychopathological concepts of the psychiatric adult. During childhood fear and sadness are developed, but it changes progressively since breastfeeding and childhood until adolescence. Frequently, anxiety and depressive disorders are expressed in the same individual at the same time, probably because fear is frequently accompanied by sadness in these pathologies. Anxiety disorders are the most frequently psychiatric disorders in the pediatric period, but most patients might not receive pharmacological or psychological treatment. The social anxiety, the anxiety by separation and generalized anxiety produce high suffering; interfere in educational performance and social relationships. In addition, anxiety in adolescence increases the risk of psychiatric disorders in the adult stage; increase the risk to develop anxiety disorders, major depression, suicide attempts and clinical hospitalization associated with psychiatric illness [14-16]. The aforementioned may negatively impact the educational performance in students.
Epidemiological studies have reported that anxiety disorders are common in children and adolescents [17] and are comorbid to depressive disorders in 8–17-year-olds [18, 19]. Data of anxiety prevalence from the United States of America reported in DSM-5 showed 0.9% for generalized anxiety in adolescents; prevalence of anxiety separation disorder in children younger than 12 years old is approximately 4% and decreases through adolescence to approximately 1.6%; for specific phobia prevalence rates are approximately 16% in adolescents; social anxiety prevalence of 7% is similar in adolescents and adults decreasing with age; agoraphobia prevalence is 1.7% [20]. Sexual dimorphism is common for anxiety disorders. More female are affected by anxiety disorder than males with 2:1 to 3:1 preponderance in adolescence [21-23] and the age of onset for anxiety symptoms in the United States is 14 years [24].
For adults and adolescents there are challenges in distinguishing “normal” from “pathological” fear and anxiety, and there is some controversy regarding whether anxiety disorders differ from “normal” fears and worries by kind or degree [14]. Practically, transient worries and fears are common in children and adolescents, but are considered pathologic only when associated with significant impairment, distress and persistence. As mentioned, sweating, shaking and blushing are obvious signs of anxiety but some other elusive behavioral signs in young people make it difficult to detect it. For example, somebody may find it difficult to associate increased inflexibility, over-reactivity, emotional intensity, impulsivity, anger, constant arguments, trials to escape or avoid school or exams, for example, to anxiety-related behaviors associated to an underlying cause. In addition, anxiety disorders have a somewhat different age and gender distribution during childhood and adolescence. Excessive worries about past behavior, self-image, competence and socio-sexual acceptance, excessive perfectionism, somatic complaints, onicophagia, nightmares, trichotillomania and internal tension are common in adolescents [25]. Panic disorder and social phobia are more frequent in adolescents [26]. Female adolescents have higher rates of specific phobia, post-traumatic stress disorder and panic disorder [27, 28]. In addition, anxiety disorders in adolescents often co-exist with either another anxiety disorder or another psychiatric disorder [29].
3.2. Depression
Negative cognitive functioning, cognitive distortions, negative attributions, hopelessness and low self-esteem are common in children, adolescents and adults. But the central symptoms of depression such as anhedonia and helplessness could also be a problem for detecting the disorder on time at school. It is important to know that adolescent onset is associated with a more chronic, severe and disabling form of depression, higher rates of family history and more suicide attempts than depression that first emerges in adulthood [30]. Adolescents with major depression disorder have recurrent episodes; and they differ from adults because sadness is not so prominent but they are more likely to present with irritability, anhedonia, suicidality, hypersomnia, cognitive and circadian rest–activity rhythm problems [31-33]. Although the diagnostic criteria are similar for children and adolescents, typical symptomatology differs by age group. Kovacs [34] noted that adolescents report more hypersomnia, fewer appetite and weight changes, and fewer reported delusions than children, and depressed preschool children show typical symptoms of depression, such as mood disturbance and anhedonia, but have less “masked” symptoms (e.g., sleep problems, appetite changes). In severe depression, the incidence of suicide progresses with age in the United States. Rare cases of suicide are observed before 10 years old children and surprisingly expand to 100-fold up to 14 years, being 10 times higher between the ages of 15 and 19. Similar to anxiety disorders, prevalence rates for depression are higher in females than males from adolescence but not before [35]. The age of female depressed adolescents is associated to a hormonal mechanism activated by menarche, in which anxiety, fatigue and sleep/appetite disturbances are observed [36]. For those who experience premenstrual dysphoric disorder in which body image dissatisfaction, feelings of failure, concentration problems and work difficulties are common, there is a hypothesis of withdrawal syndrome of progesterone to explain symptomatology; this observation has been observed in clinical and preclinical studies [37]. In summary, female adolescent are likely to exhibit more cognitive and somatic symptoms and boys experience elevated “boredom” possibly because depressed boys are more anhedonic [38].
Comorbidity of 30–75% of anxiety disorders and depression is reported in adolescents, which is associated with severe anxiety symptoms [39-41] and greater suicidality [42].
4. Diagnosis
There is a concern that many children and adolescent with anxiety and depression may not be receiving appropriate diagnosis and treatment. Diagnosis of affective disorders in adolescents and young adults could be difficult for many reasons, impossibility to reach mental health facilities, lack of professional training and scarcity of child and adolescent psychiatrists. Maybe it takes longer to diagnose an affective disorder in young than adults due to the common symptoms shared by other comorbid disorders [43, 44]. Diagnosis of anxiety and depression in adolescents requires clinical interviews of the adolescent and parent separately, using both open-ended questions and specific symptom review as well as with children. In addition to assessing for symptoms, the evaluation will also include the assessment of comorbid conditions (both general medical conditions and psychiatric illnesses), and the assessment of contextual factors (i.e., peer and family relationships, school/work, stressors). To Arrivillaga and collaborators [45], the family history of affective disorders with conditions, experiences of negative events, such as parental loss in childhood, the absence of a confident, living in a chaotic family environment and physical or psychological abuse are vulnerabilities to suffer depressive symptoms.
The first step in the differential diagnosis of a given symptom or complaint is typically a search for unrecognized physical disease. Although most adolescents with cognitive and physical symptoms consistent with an anxiety disorder will not be found to suffer from causal physical disease, clinicians should entertain the hypothesis that anxiety might be caused, exacerbated or perpetuated by an unrecognized general medical condition. This is important to emphasize because behavioral health professionals, although having little difficulty accepting that mental disorders are commonly underdiagnosed and undertreated in general medical settings, are vulnerable to overlooking the often important relationship between anxiety and physical disease in traditional mental health settings. The onset and duration of specific cognitive and somatic symptoms of anxiety should be examined and an attempt made to identify a temporal relationship between symptoms of anxiety and the course of the comorbid general medical condition. Inquiry should be made regarding recent and past stressors and traumas, including medical traumas as well as academic problems, family issues, maltreatment and difficulties with peers such as bullying. There is no substitute for a comprehensive psychiatric and medical history, as well as review of the medical record, medication list, laboratory and other diagnostic tests and procedures, and a directed physical examination when appropriate. Children with chronic physical illness are at increased risk to develop anxiety disorders. So anxiety can predispose to physical health problems and negatively impact the course of comorbid physical disease [46]. In addition, anxiety and depression must be differentially diagnosed from attention-deficit /hyperactivity disorder (ADHD) because they share some symptoms such as inattention; the difference is that anxiety inattention is due to worry and rumination, and depressive youths present poor concentration only during depressive episodes, which is distinguished from inattention due to the attraction to external stimuli, new and enjoyable activities observed in ADHD disorder [3].
Diagnosis criteria for anxiety and depression are found in the DSM-5 or ICD-10 among other documents for diagnosis. In students a sudden fall in grades may be a sign of lack of concentration associated to mood or anxiety disorder. Underdiagnosis and undertreatment of anxiety and depression in children and adolescents are not only a matter of mental health services; members of the family, friends and teachers can provide useful information to an early detection of these disorders, and the problem, for example, is the lack of acceptance in some families, the lack of awareness to identify depression symptoms because parents are also depressive, the atypical presentation of symptoms that may be confused or unclear for relatives, and the scarce communication of negative emotions and thoughts that may lead to somatization (general aches and pains, headaches or stomachaches) in children and adolescents [3]. Older age must be easier to diagnose because of the capacity of communication between individuals, but it is not so simplistic. Depressive symptoms in adolescence will have continuity to depression in adulthood; this has been observed in homeless adolescent victims of adverse experiences early in life [47]. Monteiros and collaborators [48] explain that traumatic experiences among young men and women can be a predictor of depressive symptoms and moderate the effect on the emotional reactions of gender. The diagnosis of primary depressive mood disorders requires that physicians also rule out depression from physiological effects of other medical conditions, that is, endocrinopathies, malignancies, chronic and infectious diseases, anemia and vitamin deficiency [3], and from medications such as Isotretinoin, which is used for acne problems [49]. The DSM-IV-TR and recent DSM-5 criteria for diagnosing major depressive disorder in children and adolescents are similar to those for adults [3, 50-53]. If substance abuse is present, an independent diagnosis of major depression requires the presence of depression before substance abuse or during periods of remission. Concurrent treatment of substance use disorder and depression is needed to improve outcomes for both [54]. Although less common, bipolar disorder is an important differential diagnosis. In 40% of children and adolescents with bipolar disorder, the illness begins with a major depressive episode [55]. Physicians should maintain a higher level of surveillance in patients at greater risk of bipolar disorder.
Other concerns are psychiatric emergencies. In developing countries, staff in schools and hospitals have little knowledge about psychiatric emergencies in young people, which is worsened by the fact that sometimes saturation in primary attention, the lack of mental services, medical insurance or health facilities make difficult the communication with emergency services and vice versa [56] and could interfere with the appropriate diagnosis leading to a subdiagnosis or misdiagnosis in youth.
5. Treatment
Safe and effective treatment for anxiety and depression requires accurate diagnosis, a detailed family history, suicide risk assessment and the use of evidence-based therapies [57]. Despite increasing evidence of effective treatments in the pediatric age group, adolescents with depression (major depressive disorder, dysthymia, depression not otherwise specified or “minor depression,” and adjustment disorder with depressed mood) receive inadequate treatment [57]. Furthermore, physicians uncomfortable with prescribing complex therapies should consider referral to a child psychiatrist, especially for patients with multiple comorbidities [58]. Sometimes there is a lack of sufficiently informative comparative studies of different treatments (i.e., for depressive and anxiety disorders in childhood and adolescence) in health-care systems [21, 59].
Cognitive-behavioral combined with interpersonal approaches may help in prevention and mild depression. A mild depressive disorder without comorbidity or significant risk factors can be initially managed with support in coping with everyday tasks and counseling or psycho-education about the manifestations of the disorder, its causes, the expected course and the options for treatment for six to eight weeks. Psychotherapy interventions of all kinds have been found to lessen depression more effectively over the short term (mean, 12 weeks) in children and adolescents (age 6–18) than various alternative management strategies. Cognitive-behavioral therapy, interpersonal psychotherapy or other kinds of psychological interventions are recommended for depression in adolescents [59]. When needed, pharmacotherapy is applied to young people. Fluoxetine is the only one drug approved for the treatment of depressive disorders in children and adolescents and sometimes fluoxetine can be combined with psychotherapy for better results. However, the adverse effects of selective serotonin reuptake inhibitors (i.e., headache, vomiting, sleep disturbance, fatigue and loss of appetite at the start of treatment) and their controversial tendency to reinforce suicidal ideation make psychotherapy the first choice to start treatment. Afterward, if needed, the fluoxetine or almost any drug should be given at lower doses than for adults increasing them progressively to be near the adult dose [60, 61].
Modern information technologies offer new opportunities to deliver mental health interventions via computer-based or mobile phone-based internet, which include online self-help with therapist support via email, SMS and/or phone call, family support, school-based group support and teacher support. A meta-analysis showed that this kind of treatment was apparently effective in reducing anxiety symptom severity compared to no intervention, and this effect may be equal to that of face-to-face interventions. The meta-analysis found a larger effect size for anxiety than for depression but the interpretation of the findings analysis needs to consider several factors and has methodological limitations. However, given the rapid adoption of mobile devices among children, youth and young adults, it is also important to develop and evaluate mobile device-based interventions [62].
6. Social problems associated with anxiety and depression
Anxiety and depression in youth result in functional impairment, increased difficulties with schoolwork, peer and family relationships. There are a range of predictors of anxiety and depression disorders in children and adolescents. These include various indices of social disadvantage such as increased family size, overcrowding, low socioeconomic status, family disruptions, parental non-employment, father’s criminality and school disadvantage [63]. Anxiety and depression and other mental disorders have impact on several aspects of personal and social functioning. Patients may not complete even secondary school because the early onset of a mental disorder prevents attainment of goals at school, and even more, they tend to get married before the age of 18 and divorce later [64]. Depression is considered disabling, even more than physical illness, in a social context in daily activities or otherwise productive task [65]; and sometimes depressed people tend to use more health services than other diseases; therefore health costs are also significant. Wagner and collaborators [65] mention that people with anxiety or depression disorders have higher rates of utilization of health services, with a higher cost of care. Ritakallio and collaborators [66] found that depression and antisocial behavior among adolescents had considerable continuity, and concurrent comorbidity between these disorders was high. In relation to suicide, Aradilla and collaborators [67] found in a sample of nursing students that emotional care, self-esteem and depression are risk factors for suicidal thoughts, in which women were found to have a high significance of correlation. Also depressive symptoms were associated with other risk behaviors such as alcohol and snuff, besides violence. In other study [68], depression showed to be a risk factor of suicidal behavior in adolescents: suicide ideation was present in male (75%) and female (83.2%) adolescents with depressive symptomatology, and 77.3% of male and 64.8% of female depressive adolescents had attempted suicide. In the study by Vázquez and Blanco [69], suicidal ideation also correlates with poor subjective and negative self-judgment, pessimism and low self-esteem, which is compounded by the stress of academic life, the kind of experiences in early life and personality.
7. Academic achievement
Academic achievement has been identified as a high prevalence of anxiety in the population of college students, even above the prevalence of depression, which is dependent on the age and gender of the study population. Anxiety in adolescents depends on the concept of the student about school demands related to comprehension and auto-control. He or she frequently faces academic situations whose demands must compare with his or her own resources. When evaluation of school tasks lead to conclude that they are more than he or she can do then threat and humiliation are experienced and justify rejection to school. Teachers face many challenges mainly when new policies in education indicate the evaluations of teaching and learning in a standardized form without understanding particular needs in each environment. Hence, an intense anxiety in evaluations reduces scholar performance, affecting self-esteem and social relationships [70]. A study with Mexican male and female 21–26 years old at university showed that students with the lowest academic performance had highest levels of negative interference in Stroop paradigm about school failure; also there was a direct relation between the academic auto-concept and performance in exams; students who had been systematically located in the lower levels of the study index showed the highest levels of anxiety [71]. The finding of an inverse relation in anxiety to examinations and grades had also been observed in university students in the United States [72].
Also, there is a negative relationship between adolescent depression and educational achievement, being that depression affects academic achievement and not the other way around [64, 73]. Humensky and collaborators [74] showed an association between the self-perception of depressive symptoms in adolescents and difficulties to concentrate and complete school tasks making a detrimental cycle. Furthermore, adolescent depression and its consequences might be particularly destructive to subsequent higher education in males [75].
Depressive episodes in the education of students affect learning ability, academic performance and adaptation to college life as well as performance of future professionals. Frojd and collaborators [76] also found association between severity of depression with concentration difficulties, social relationships, self-learning, academic performance, and reading and writing in 13–17-year-old youth.
In other study it was found that the prevalence of depressive symptoms in college students affects almost one-third of the population [77]. Other studies have suggested that the incidence of depression in college students decreases if there are positive adjustments to academic life and adequate social support to cushion stressful scholar stimuli. In this sense, it has been found that when increase women education depression decreases compared to men [78]. Perhaps it is because education increases the levels of creativity in women compared to men.
Parent, child and teacher reports of emotional and behavioral problems to recognize the existence of a situation in school might be limited. Mason et al. suggest the need of studying the course of the emotional and violent behavioral problems from childhood to adolescence reported at school, because more readily identifiable symptoms of depression and anxiety may emerge later in adolescence [79].
Depression and anxiety are serious problems for students in both developed and developing countries. In a study with 139 male Mexican adolescents 18 years old who finished high school, it was observed that mild depression evaluated by mean of the Zung Self-Rating Scale was frequent in students with very low grades; a higher score in depression was observed in those guys who fail to approve the college entrance examination [80]. This suggests that depressed students are shown to have problems with academic work and motivation, and report receiving lower grades than non-depressed students. The problem is that in the future depression symptoms are related to work absences and impaired work performance, and results partly confirmed that work stressors add to this impact [81]. A study of 145 university students at Mexico evaluated the score of the Zung Self-Rating Scale for depression in 21-year-old male guys and showed 55% of students with mild depression and 9% with moderate depression. The latter reported to live with dysfunctional family, to have a self-perception of poor mental health and augmented body weight, as well as to fail more subject written exams [82]. Brain alterations in depression affect the affective behavior as well as cognitive and intellectual aspects in university students [83].
Studies about scholar performance vary in sample age and multifactorial aspects of low grades and individual dysfunction; however, there is an agreement in ensuring attention as soon as possible to give an appropriate treatment to young people.
8. Conclusion
To ensure the scholar success of anxious and depressive students is necessary to clinically manage the disorders. Teachers must consider anxiety and depression as illnesses. It is more difficult for adolescent patients to practice the usual methods of studying. The intensity of emotional tension experimented depends on the cognitive auto-concept of examinations and the capacity to face them. Sometimes, the relationship between anxiety and school performance is indirect because of the valuation of auto efficacy, which means that people with low perception of auto efficacy generate high levels of anxiety. For a diagnosed anxiety or depressive disorder in adolescents and university students, school staff should communicate the problem to allow medical attendance on time.
It is notable that both chronic and acute psychosocial stressors are significant predictors of anxiety disorders and depression. Solutions to low school performance related to anxiety and depression in young people are complex but most of the times depend on family commitment and integration of health promotion services into medical care and school settings. Nowadays, adolescence is strongly related to anxiety and depression disorders, more than any other time of life, and both disorders are related to other psychiatric disorders and substance abuse that negatively impact the academic performance. In addition, the environment plays an important role in the formation of personality and psychiatric illness. There are different types of environments, social, natural, built and virtual, each of which has different effects on human behavior, but few studies about the effects of different types of environment on mental health are available. The social environment, comprising the interactions, networks and social support, for example, social crisis, economic, social mobilization and public policy, can be stressors in which adolescent are involved. Similarly, the virtual environment, such as using the Internet or any other media, where ideal bodies are broadcasting or offering beautiful bodies, can also be stressors. The fact is that adolescence is a vulnerable period in development because of physical, biochemical and social changes that are experienced during this time in spite of the differences in culture, gender, socioeconomic status and education level that lead to cope with external demands and stress. The aforementioned show the importance of identity anxiety and depressive symptoms in this particular population of students, to improve the mental health and academic performance in high school and university students.
Acknowledgments
Present chapter was partially supported by Consejo Nacional de Ciencia y Tecnología, México (CONACyT: Proyecto 1840), Cuerpos Académicos UVE-CA-25, UNPA-CA-26 and Programa de Fortalecimiento Académico del Posgrado de Alta Calidad I010/152/2014C-133/2014.
\n',keywords:"anxiety, depression, scholar performance, students, education, mental health",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/48585.pdf",chapterXML:"https://mts.intechopen.com/source/xml/48585.xml",downloadPdfUrl:"/chapter/pdf-download/48585",previewPdfUrl:"/chapter/pdf-preview/48585",totalDownloads:4369,totalViews:6160,totalCrossrefCites:15,totalDimensionsCites:17,totalAltmetricsMentions:1,impactScore:12,impactScorePercentile:98,impactScoreQuartile:4,hasAltmetrics:1,dateSubmitted:"November 15th 2014",dateReviewed:"April 27th 2015",datePrePublished:null,datePublished:"September 9th 2015",dateFinished:"June 19th 2015",readingETA:"0",abstract:"Emotional processes are important to survive. The Darwinian adaptive concept of stress refers to natural selection since evolved individuals have acquired effective strategies to adapt to the environment and to unavoidable changes. If demands are abrupt and intense, there might be insufficient time to successful responses. Usually, stress produces a cognitive or perceptual evaluation (emotional memory) which motivates to make a plan, to take a decision and to perform an action to face successfully the demand. Between several kinds of stresses, there are psychosocial and emotional stresses with cultural, social and political influences. The cultural changes have modified the way in which individuals socially interact. Deficits in familiar relationships and social isolation alter physical and mental health in young students, producing reduction of their capacities of facing stressors in school. Adolescence is characterized by significant physiological, anatomical, and psychological changes in boys and girls, who become vulnerable to psychiatric disorders. In particular for young adult students, anxiety and depression symptoms could interfere in their academic performance. In this chapter, we reviewed approaches to the study of anxiety and depression symptoms related with the academic performance in adolescent and graduate students. Results from available published studies in academic journals are reviewed to discuss the importance to detect information about academic performance, which leads to discover in many cases the very commonly subdiagnosed psychiatric disorders in adolescents, that is, anxiety and depression. With the reviewed evidence of how anxiety and depression in young adult students may alter their main activity in life (studying and academic performance), we discussed data in order to show a way in which professionals involved in schools could support students and stablish a routine of intervention in any case.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/48585",risUrl:"/chapter/ris/48585",book:{id:"4651",slug:"a-fresh-look-at-anxiety-disorders"},signatures:"Blandina Bernal-Morales, Juan Francisco Rodríguez-Landa and\nFrank Pulido-Criollo",authors:[{id:"45701",title:"Dr.",name:"Blandina",middleName:null,surname:"Bernal-Morales",fullName:"Blandina Bernal-Morales",slug:"blandina-bernal-morales",email:"bbernal@uv.mx.uat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universidad Veracruzana",institutionURL:null,country:{name:"Mexico"}}},{id:"45702",title:"Dr.",name:"Juan Francisco",middleName:null,surname:"Rodríguez-Landa",fullName:"Juan Francisco Rodríguez-Landa",slug:"juan-francisco-rodriguez-landa",email:"juarodriguez@uv.mx",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/45702/images/system/45702.png",institution:{name:"Universidad Veracruzana",institutionURL:null,country:{name:"Mexico"}}},{id:"175891",title:"MSc.",name:"Frank",middleName:null,surname:"Pulido-Criollo",fullName:"Frank Pulido-Criollo",slug:"frank-pulido-criollo",email:"fpulido@unpa.edu.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Anxiety and depression",level:"1"},{id:"sec_2_2",title:"2.1. Concept",level:"2"},{id:"sec_4",title:"3. Anxiety and depression in adolescents",level:"1"},{id:"sec_4_2",title:"3.1. Anxiety",level:"2"},{id:"sec_5_2",title:"3.2. Depression",level:"2"},{id:"sec_7",title:"4. Diagnosis",level:"1"},{id:"sec_8",title:"5. Treatment",level:"1"},{id:"sec_9",title:"6. Social problems associated with anxiety and depression",level:"1"},{id:"sec_10",title:"7. Academic achievement",level:"1"},{id:"sec_11",title:"8. Conclusion",level:"1"},{id:"sec_12",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'Nieuwenhuys A, Oudejans RR. Anxiety and perceptual-motor performance: toward an integrated model of concepts, mechanisms, and processes. Psychological Research 2012; 76(6):747-759.'},{id:"B2",body:'Cody MW, Teachman BA. Global and local evaluations of public speaking performance in social anxiety. 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Estrés, miedo, ansiedad y depresión. In: Coria-Ávila GA (ed), Neurofisiología de la conducta. México: Universidad Veracruzana; 2012, pp. 136-150.'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Blandina Bernal-Morales",address:"bbernalm10@hotmail.com",affiliation:'
Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, México
'},{corresp:null,contributorFullName:"Juan Francisco Rodríguez-Landa",address:null,affiliation:'
Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, México
Licenciatura en Enfermería, Universidad del Papaloapan, campus Tuxtepec, Sistema de Universidades Estatales de Oaxaca, Tuxtepec, Oaxaca, México
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1. Introduction
Arsenic (As) is the one the most toxic element present in earth which poses a serious health hazard to animal and human health. Generally arsenic is present in the earth crust in the form minerals, especially associated with iron pyrite and zinc ores. Arsenic contamination occurs through both by natural as well as anthropogenic processes [1]. Unlike other toxic heavy metals (Cadmium, mercury and chromium) arsenic contamination in environment predominately occurs through natural biogeochemical process [2] and some manmade activities play important role (triggering the process) in that process. Anthropogenic activities such as coal mining and burning smelting of As containing metal ores and other industrial activities are also responsible for distribution of arsenic in the environment [3]. Arsenic contamination of drinking water in South and Southeast Asia reported one of the most threatening problems that causes serious health hazard of millions of people of India and Bangladesh [4]. The source of As contamination in water in those countries were due to two different natural processes; oxidation of arsenopyrite minerals lies below ground water table due to water mining process and reduction of As containing iron hydroxides [5]. Arsenic exists in the nature in −3, 0, +3 and + 5 oxidation states and environmental forms include arsenious acids, arsenic acids, arsenites, arsenates, methylarsenic acid, dimethylarsinic acid, arsine, etc. Two inorganic forms are very common in natural waters: arsenite (AsO33−) and arsenate (AsO43−), referred to as arsenic (III) and arsenic (V). Pentavalent (+5) or arsenate species are AsO43−, HAsO42−, H2AsO4− while trivalent (+3) arsenites include As(OH)3, As(OH)4−, AsO2OH2− and AsO33−. The solubility of inorganic species depends on pH and redox potential of the environment and arsenite (As3+) is the most soluble form inorganic As. Pentavalent species or arsenate (As5+) predominate in oxygen rich aerobic environments, where as trivalent arsenites (As3+) dominant in moderately reducing anaerobic environments such as groundwater [4].
Arsenic concentration in drinking water reported more than 50 μg L−1 in many areas in the world [6], whereas maximum permissible limit set by World Health Organization (WHO) is 10 μg L−1. The use of arsenic contaminated ground water for irrigation purpose causes build up of As in soil and leads to entry of As in food crops, especially in rice and vegetables [7, 8]. This causes serious health hazard, in those As containing areas. In Southeast Asian countries like Bangladesh, Eastern parts of India (West Bengal and Bihar) and Vietnam, rice is consumed as major staple food and is very efficient in As translocation in grains [9]. Thus rice crop play a major pathway for As entry in human body living in those contaminated areas apart from drinking water. Thus remediation of arsenic contaminated water is important for environmental point of view. Various technologies are for remediation of arsenic contaminated water like ion exchange, electro dialysis, membrane filtration, adsorption and coagulation-flocculation generates lot of arsenic enriched waste. That waste material generally dumped or disposed in nearby surroundings, from where arsenic can also come back to soil and water by leaching thus making system susceptible to arsenic contamination. Along with above mentioned problem, huge cost is involved in this existing arsenic remediation technology. That necessitates finding out an alternate low cost technology which can take care of arsenic contaminated water.
Phytoremediation is an alternate and low cost technology that utilizes green plant to extract arsenic from water and store it vegetative cells. Phytoremediation process includes phytoextraction, phytostabilization, phytovolatilization, phytotransformation, and rhizofiltration [10]. Researchers find out that plants uptake arsenic by roots through phosphate uptake pathway and transfer it their above ground parts (shoot and leave). But how much amount of arsenic translocated from source (water) to sink (plant parts) depends on phytoremediation efficiency of the plant concern. However, more than 90% of total arsenic accumulated into the plant is stored in roots.
The plants utilized for phytoremediation have some criteria like (1) plant have higher specific growth rate under contaminated environment, (2) higher translocation capability of the toxic element concerned [11]. Metal translocation capability depends on factors like (1) bio concentration factor (BCF) and (2) translocation factor (TF). Plants having BCF >1 are ideal for Phytoremediation. Chinese brake fern (Pteris vittata) is the most promising plant for phytoremediation of arsenic from contaminated soil [12]. For instance, plants species like water hyacinth (Eichhornia crassipes), duck weed (Lemma minor, Spirodela polyrhiza and Wolfia globosa), water lettuce (Pistia stratiotes) and fern (Azolla pinnata) have been successfully utilized for arsenic removal from water purpose by many researchers [13, 14, 15]. Among the semi aquatic weeds. Apart from these free floating aquatic weed flora such as Arundo donax, Vetivaria sp., and Alternanthera philoxeroides had been successfully utilized for remediation of As contaminated water [16, 17]. In this chapter we are going to discuss about arsenic removal potential of various aquatic and semi aquatic weeds along with their future use for phytoremediation purpose.
2. Phytoremediation pathways
The terminology “Phytoremediation” consists of two words, “Phyto” means “green plants” and “remediation” means “curative measures or restoration”. The word “phytoremediation” was first given by Chaney [18]. In phytoremediation process, generally green plants are used which uptake toxic chemical substances (such as heavy metals and metalloids, pesticide residues etc.) from contaminated sites (soil and water) by various mechanisms and remove them from environment. Various crop and weed plants are found to be suitable for phytoremediation purpose. But research results indicated that weed flora had higher phytoremediation potential than cultivated crops (Example- Brassica sp). There are various pathways of phytoremediation process such as, rhizofiltration, phytoaccumulation or phytoextraction, phytostabilization, phytodegradation or phytotransformation and phytovolatilization etc.
Rhizofiltration: Plants uptake toxics substances by their roots through adsorption or absorption process and sequester in their root system. Aquatic plants mainly exhibited this process.
Phytoaccumulation or phytoextraction: Plants uptake toxic substances by their root system and translocated to other plant parts such as stem and leave or other modified plant parts. This mechanism mainly exhibited this process are suitable for remediation of contaminated soil.
Phytostabilization: In this process, plants restrict movement of toxic substances in soil or water, thus reduced their availability to plants. In this method, plants do not uptake toxic substances from environment. Rather, plants secrets some root exudates or photochemicals which form stable chemical bond with toxic substances and increases its stability in environments.
Phytodegradation or Phytotransformation: In this process, plants uptake toxic substance from soil or water and degrade these primary toxic substances into nontoxic forms. A large number of metabolic and physiological factors are involved in this process.
Phytovolatilization: Plant uptake toxic substances by their root system and translocated to their aerial plant parts especially in leaves; and release toxic substances in the form of vapor which may not be toxic as their primary source.
Apart from this there are some other terminologies often used in phytoremediation process are bioconcentration factor (BCF) and translocation factor (TF).
BCF = toxic substance uptake by plant/toxic substance present in environment (soil or water).
TF = toxic substance present in shoot or stem/toxic substance present in roots or.
Toxic substance present in leaves/Toxic present in shoot or stem.
For, Hyper accumulator plants both BCF and TF is >1 is desired. In other words, plants suitable for phytoremediation, BCF >1 is always desirable. But for aquatic weeds, as their dominant pathways is rhizofiltration; their toxic substances BCF >1 but TF for root to shoot or shoot to leaves is <1.
3. Potential of various aquatic plants for phytoremediation
3.1 Phytoremediation by free floating aquatic weeds
Eichhornia crassipes:Eichhornia crassipes is commonly known as water hyacinth, a free-floating perennial aquatic plant native to tropical and sub-tropical South America, and is now wide spread in all tropic climates. The genus Eichhornia comprises seven species of water hyacinth among which E. crassipes is the most common and have been reported to grow very first. However, its enormous biomass production rate, high tolerance to pollution and absorption capacity of heavy-metal and nutrient qualify it for use in wastewater treatment [19].
The capability of removing arsenic from contaminated water was earlier observed by Misbahuddin and Fariduddin [20] and they observed that water hyacinth can removes arsenic from water within 3–6 hr. exposure time. Amount of arsenic removed depends on number of the plant used, exposure time, presence of air and sunlight. They concluded that whole plants were more effective than fibruous roots alone. It was observed that dried roots of water hyacinth can rapidly reduces As content in contaminated water within below WHO recommended critical level (<10 μg Lg−1) [21]. A fine powder was prepared from dried roots of water hyacinth plants (obtained from Dhaka, Bangladesh) removed more than 93% arsenite and 95% of arsenate from a solution containing As @ 200 μg L−1 within 1 hr. exposure time [21]. Higher biomass production ability of water hyacinth allow it to remove As at higher rate (600 mg As ha−1 day−1) and greater efficiency (17%) compared to lower biomass producing aquatic macrophytes such as lesser duck weed (Lemna minor) which removed As at lower rate (140 mg As ha−1 day−1) and lesser efficiency (5%); though there was no difference in bioaccumulation capacity [13]. Similarly better As extraction capacity of water hyacinth (80%) compared to Lemna minor and Spirodella Polyrhiza from tropical coalmine effluent was also been reported [22] from India. Unlike lower biomass producing aquatic macrophytes, water hyacinth poses better As extraction ability compared to higher biomass producing vetivar grass [23]. Not only higher biomass, higher reproduction ability also plays an important role in As phytoremediation by water hyacinth. Water hyacinth was a suitable phytoremediation agent when As present in contaminated water at lower concentrations. When As was provided at lower concentrations @ 1 and 2 mg L−1, water hyacinth removed 90 and 65% of total As from contaminated solutions (1 and 2 mg L−1 respectively) provided respectively within 7 days [24] and maximum As stored in roots. Water hyacinth can extract higher amount As from contaminated water but their presence in water bodies reduces dissolved oxygen content (DOC), which makes its application for a larger water bodies a problematic pathway which needs to be taken care.
Pistia stratiotes: Pistia stratiotes is commonly called as water lettuce There are many previous studies indicated that Pistia stratiotes capable of removing toxic heavy metals from contaminated water [25, 26, 27], but there were few studies was done on As uptake by water lettuce. Earlier a field study carried out using P. stratiotes and results showed that Pistia stratiotes can remove As from contaminated water, along with higher bioconcentration factor (BCF) for root (8632) vis-à-vis lower BCF for leaf (2342) [28]. In a laboratory study it was demonstrated that maximum As removal efficiency of P. stratiotes was found at pH 6.5 and Pistia removed 87.5% of the metalloid provided in the solution [29]. From Laboratory study it was revealed that P. stratiotes can accumulate As efficiently when As was provided at lower concentrations, though total As uptake was increased with increase in As concentration in the solution [30]. Arsenite accumulation in P. Stratiotes was found more in root and less in leaves like water hyacinth. Arsenic accumulation in roots and leaves were respectively 1120 and 31.60 μg g−1 DW respectively when 10 μM As (As3+) solutions are employed [31]. When higher concentration of As solutions used (>20 μM), As toxicity symptoms like chlorosis, suppressed growth, lower photosynthetic rate, suppressed enzymatic activities and increased cell damage were observed in P. stratiotes [30, 31].
Lemna, Spirodella and Wolfia: Weeds belongs to Lemna, Spirodella and Wolfia are generally known as Duckweeds. Duckweeds are small free-floating aquatic weed plants which generally found in water bodies, mainly comprises of four genera, Lemma, Spirodela, Wolfia, and Wolfiella, and of 34 species. Among these Lemna, Spirodela, and Wolfia have been widely reported to accumulate arsenic from contaminated water [13, 32, 33, 34]. Research studies indicated that, total As accumulation in Lemna gibba was more in field condition compared to laboratory conditions due to higher exposure time in field condition [32]. However higher accumulation of As in plant parts is not always correlated with bio-concentration factor (BCF). It was found that total As accumulation plant parts may be higher in field condition, but higher BCF was obtained at laboratory conditions [32] due to better availability of external nutrients.
However nutrients like phosphate addition may suppressed As uptake by duckweeds as both phosphorus and arsenic belongs same group-V(b) element family in periodic table [33]. In most of the phytoremediation study carried out in laboratory condition, As is provided either in the form of arsenite (As3+) or arsenate (As5+). But some studies included dimethyl arsenic acid (DMAA), an organic form of arsenic for evaluation of As phytoremediation potential of duckweed species. In a lab study, Spirodela polyrhiza was exposed to two forms of As species, arsenate and DMAA with concentrations ranged from 1, 2, and 4 μM and their interaction with phosphate (100 to 500 μM) was studied [33]. Results obtained showed that arsenate uptake was affected by higher phosphate concentrations whereas DMAA uptake was not influenced by phosphate concentration indicating that Spirodela polyrhiza had separate mechanisms for DMAA uptake. Duckweeds showed contrasting As uptake behavior when provided in two separate inorganic forms (As5+ vs. As3+) and maximum As uptake was reported with arsenite form (As3+) [34]. Spirodela polyrhiza extracted 17408 and 8674 μg g−1 As (dry weight basis) respectively from solutions containing As in the form of As3+ and As5+ (64 μM As each) respectively within 6 days [34]. Maximum amount of As extracted by duckweeds is still questionable and it is varied with As exposure time, concentrations of As in contaminated solution, and research type (laboratory vs. field study). Spirodela polyrhiza reported to uptake 400 mg kg−1 As (dw basis) without showing any toxicity symptoms, but can accumulate up to 900 mg kg−1 As (dw basis) when subjected to 320 μM ml−1 As containing solutions [35]. Under natural condition, Lemna minor was found to accumulate 430 mg kg−1 As (dry weight basis) under As contaminated environment [36]. There are few studies on As uptake by Wolfia globosa (rootless duckweed). Wolfia globosa had been reported to extract more than 1000 mg kg−1 (frond dry weight basis) from contaminated water [37]. Like other duckweeds, Wolfia globosa also uptake more arsenite form compared to arsenate form [37]. Later studies confirmed that Wolfia globosa produced phytochelatins which played an important role minimizing toxic effects of As in their body parts [38]. These above cited studies showed that Lemna minor, Spirodela polyrhiza and Wolfia globosa are suitable for phytoremediation of As from contaminated water.
Salvinia: Salvinia is a floating fern belongs to genus salviniaceae, commonly called as butterfly fern. The genus salviniaceae contains 12 different species, out of them only 3 had been investigated for As phytoremediation were namely Salvinia molesta, Salvinia minima and Salvinia natans [39, 40, 41]. Salvinia minima have been reported as an efficient scavenger of Pb (34 mg g−1 dw) and less efficient remover of As (0.05 mg g−1) from contaminated medium and uptake of both Pb and As increased with exposure time duration and concentration of the element in the medium concerned [40]. The plant showed toxicity symptoms when As3+ concentration was more than 100 μM and tolerates up to 300 μM. Addition of phosphate in solution, reduced As uptake of as occurred in other aquatic weed plant also been recorded in their study. Similarly negative impact of phosphate and iron on As uptake by Salvinia natans was observed [41]. Phosphate addition reduced As uptake when provided in the from arsenate (As5+), in contrast no impact when As was provided in the form of DMAA. Like other aquatic weeds (Eicchornia, Pistia and Spirodela), Salvinia molesta also showed As toxicity upon exposure to higher concentration. To counter As stress, antioxidant enzyme activities and reactive oxygen species (ROS) were increased in floating leaves [39]. These studies indicated that Salvinia can play an important role for As phytoremediation as it had own defense mechanism.
Azolla: Azolla is a small, free floating aquatic fern commonly found in paddy fields, ponds, river and lakes. There are numerous studies carried out globally showed that Azolla can remediate heavy metal toxicity from contaminated water [42, 43, 44]. But studies on As phytoremediation capability of azolla were scarce. In As contaminated area of Bangladesh, Mahmud et al. [45] evaluated 49 different plant species for As uptake and BCF; found that Azolla pinnata along with Eichhornia crassipes and Spirodella polyrhiza showed higher BCF and TF in paddy field. Among 49 plant species, Azolla pinnata showed highest BCF 10.92 indicated its suitability to reduce As uptake by paddy plants in field condition. A study using Azolla conducted in China using 50 different strains of Azolla spp. based on their uptake and speciation [46]. As uptake was ranged from 29 to 397 mg kg−1; A. caroliniana accumulated maximum As followed by A. macrophylla and minimum accumulation was associated with A. filiculoides when all strains were grow in 50 μM As5+ solution for 10 days (Figure 1). Arsenic speciation in followed in the order of arsenate (As5+) > arsenite (As3+) > DMAA and MMAA accounting 50–60, 25–40 and 1–5% of total arsenic in A. caroliniana respectively. In contrast, asrenite (As3+) was dominant As species in A. filiculoides governs 55–69% of total As [46]. Another study was conducted on phytoremediation of As by A. caroliniana wild using various As concentrations (0, 0.25, 0.5, 1.0 and 1.5 mg L−1) and impact of As exposure on plant enzymatic properties were investigated [47]. Maximum As uptake (386 mg kg−1) was reported at highest As concentration (1.5 mg kg−1). It was observed that peroxidases, glutathione reductase, catalase and superoxide dismutase activities were enhanced at lower As doses and reduced at higher doses. In exposure to higher As concentration, thiol content and anthocyanin production were increased and correlated with higher As uptake.
Figure 1.
Arsenic uptake pattern in different Azolla sp. (adapted from Zhang et al., 2009).
3.2 Phytoremediation of arsenic by semi aquatic weeds
Some semi aquatic weed such as Alternathera philoxeroides, Arundo donax, Vetivaria Zizinoids, Typha latifolia, Phragmites spp. and Canna spp. had been widely reported to accumulate As in their body parts from contaminated soils and water [16, 17, 48, 49, 50, 51]. Alternanthera philoxeroides had potential to extract As from contaminated water and stored in root system [52, 53]. Reports from previous studies indicates that As accumulation in A. philoxeroides followed in the order of root > stem > leaf and average BCF for root ranged from 106 to 191, when exposed to various doses of As containing solutions (1, 2 and 5 mg kg−1) under laboratory condition [52]. Under natural condition, Alternanthera philoxeroides observed to uptake 12.94 mg kg−1 total As dw from pulp paper industry water with average BCF- 3.58 and TF-0.51 [53]. Higher BCF under laboratory condition observed due to used of higher As containing solution and availability of external nutrients for weed plants which may trigger As uptake through phosphate uptake pathway.
Arundo donax is a perennial semi aquatic weed mostly found in submerged condition offer a tremendous potential to uptake As from contaminated water. Earlier research work showed that Arundo donax can grow efficiently up to 50–600 μg L−1 As concentration without showing any toxicity symptom and maximum As uptake, BCF (15), TF (4.93) were recorded at 600 μg L−1 [16]. Toxicity symptoms appeared when plants were exposed to solutions containing 1000 μg L−1 As [16]. Further, combined use of plant growth promoting rhizobacteria (PGPR) such as Stenotrophomonas maltophilia and Agrobacterium sp. increased bioaccumulation of As in roots of Arundo donax plant upon exposure to higher concentration As (20 mg kg−1) and enhanced overall phytoremediation efficiency of Arundo donax in presence of PGPR bacteria [51]. The As accumulation in Phragnites austratlis followed in the order of roots > rhizomes > leaves and maximum total As uptake was registered 32.5 mg kg−1 [54].V. zizinoids, another semi aquatic weed reported to be capable of extracting As from contaminated water [17, 55]. In a hydroponic study (21 days), root to shoot As uptake it was increased with increase in As concentrations by V. zizinoids can uptake [17]. The BCF and TF for As were 10 and 0.86 indicates that V. zizinoids was an As hyper accumulator and stored higher proportion of As in their root system. Combined use of arbuscular mycorrhizal fungi (Glomus spp.) enhanced As uptake capability and growth of vetivar grass (Chrysopogon zizanioides) [55]. Typha latifolia also had the potential to uptake higher proportion of As from contaminated environment (soil), but most of the studies conducted using Typha latifolia were focused in soil. Most of the studies showed that semi aquatic weeds store more As in their root system and lower in upper vegetative parts. Higher plant vigor, higher As extraction capacity and perennial nature make them suitable phytoremediation agent for constructed wetland system. Combined use of submerged weeds like Hydrilla, Ceratophyllum, Potamogeton along with semi aquatic weeds (Arundo donax, Vetivaria zizinoids, Phragmites spp. and Typha sp.) and PGPR like VAM, As oxidizing bacteria may be highly useful to treat and remediate As contaminated water in constructed wetland system. Semi aquatic weeds are highly efficient when As present in higher concentrations and when As concentration in the system become lower submerged weeds come to play their role, as they are highly efficient As remover at lower concentrations. Again use PGPR will increase overall phytoremediation efficiency. Future research may be undertaken in these aspects for better information and output.
3.3 Phytoremediation by submerged aquatic weeds
Among the submerged aquatic weeds Hydrilla verticillata, Ceratophyllum dermersum, Potamageton crispus, Valisnaria natans, Eleocharis acicularis and Elodea Canadensis widely reported by many researchers to extract As from contaminated water. Studies conducted in laboratory and field conditions indicated that Hydrilla verticillata, and Ceratophyllum demersum can uptake higher proportion of As from contaminated water depending on exposure time and concentration of metalloid [22, 56, 57]. Unlike Spirodela polyrhiza, Hydrilla verticillata also uptake more arsenite (As3+) form rather arsenate (As5+) form [50]. Under simulated field condition (aquatic pond) Hydrilla verticillata alone removed sum total 8546 μg (348 μg g−1) of As from contaminated water (As concentration 1500 μg L−1) which is 72% of the total arsenic supplied [56]. Ceratophyllum demersum reported to accumulate 76 μg g−1 in 4 days and and As accumulation further increased to 201 μg g−1 in 7 days when exposed to 50 μM As solutions [22]. Maximum As accumulation by Ceratophyllum was recorded 525 μg g−1 dw when subjected to with 250 μM As5+ solution for 7 days [22]. Uptake of As by Ceratophyllum demersum depends on species of As present (As3+ vs. As5+) and pH of the medium. Maximum uptake of As3+ by Ceratophyllum was reported at pH 6.5 [58]. This variation in selective uptake of As species largely depends on uptake pathways and plant metabolism.
In natural conditions, submerged weeds grow in water bodies in association with floating macrophytes. Use of Combinations of submerged and floating weeds found more effective for phytoremediation purpose than submerged and floating weeds alone. Research work carried out using Hydrilla, Certophyllum, lemna and Wolfia at various combinations showed that Ceratophyllum + lemna combination (3326 μg) combination removed maximum total As followed by Hydrilla + Wolfia (1896 μg) (Figure 2). When the contribution of single plant considered, contribution of Hydrilla is more than 50% [56]. Arsenic phytoextraction potential of five different submerged weeds namely Ceratophyllum dermersum, Potamageton crispus, Myriophyllum spicatum, Hydrilla verticillata and Vallisneria natans were compared under natural As contaminated environement [59]. Results showed that all plants accumulated more 1000 mg kg−1 dw As; highest and lowest As accumulation and BCF were associated with Vallisneria natans (BCF- 361) and Ceratophyllum dermersum (BCF- 221) [59]. Similarly ability of potamogeton spp., Myriophyllum spp. and Valisnaria app to uptake As from contaminated water were also been reported by many authors [60, 61, 62]. Arsenic uptake by various types of aquatic, semi-aquatic and submerged weeds has been outlined in Table 1.
Figure 2.
Arsenic uptake comparison between various weed plants (Hydrilla, Ceratophyllum, Wolffia, Lemna and Eicchornia) grown in singly or in various combinations upon arsenic exposure for 30 days (adapted from Srivastava et al., 2014).
Name of the plants
Key findings
Reference
Eichhornia crassipes
Removed 600 mg As ha−1 day−1 within 21 days with 18% removal efficiency when As was applied @ 0.15 mg L−1
Phytoremediation ability of various aquatic and semi aquatic weeds.
4. Mechanisms of arsenic uptake and detoxification in aquatic weeds
4.1 Mechanisms of arsenic uptake in aquatic macrophytes
Three pathways for arsenic uptake in marine macrophytes have been described – (i) active uptake through phosphate uptake transporters, (ii) passive uptake through aquaglyceroporins, and (iii) physicochemical adsorption on root surfaces. Plants mainly uptake As(V) through phosphate uptake transporters [63, 64]. As(III), DMAA and MMAA gets into the plants by passive mechanism through the aquaglyceroporin channels [64].
4.1.1 Active uptake through phosphate uptake transporters
As(V) and phosphate are chemical analogs, and compete for uptake carriers in the plasmalemma [65]. As a result, as the phosphate content rises, more As (V) is required to be desorbed in the solution. Mkandawire and Dudel. [32] and Rahman et al. [33] showed that As (V) is taken up by aquatic plants through the phosphate uptake pathway, it competes with phosphate for uptake in tissues of L. gibba L. and S. polyrhiza L.
4.1.2 Passive uptake through aquaporins/aquaglyceroporins
Physiological studies indicate that these arsenic species are transported in rice through aquaporins /aquaglyceroporins via passive uptake mechanisms [66, 67]. Molecular studies revealed that Nodulin26-like intrinsic membrane proteins (NIPs), one of the major subfamilies of aquaporins transporters that promote the transport of neutral molecules like water, glycerol, and urea, are responsible for transporting As(III) into rice roots [68]. Aquaporins and aquaglyceroporins are two of three subfamilies of water channel proteins (WCPs), the transmembrane proteins that have a specific three-dimensional structure with a pore that permeates water molecules [69], which are permeable to water, glycerol, and/or other small, neutral molecules. Glycerol and As(III) compete for uptake in rice (Oryza sativa L.), indicating that this arsenic species is carried via the plasma membrane by aquaporins/ aquaglyceroporins [67].
4.1.3 Physicochemical adsorption on root surfaces
Arsenic is adsorbing and accumulating on the surfaces of aquatic plants due to suspended iron oxides (Fe-plaque). Robinson et al. [70] discovered a strong association between arsenic and iron concentrations in aquatic plants, which is believed to be due to arsenic adsorption on plant surfaces’ iron oxides. Rahman et al. [14] investigated arsenic species adsorption on precipitated iron oxides on S. polyrhiza L. roots/fronds and revealed a strong association between arsenic and iron concentrations in tissues when the plant was exposed to As (V). There was no association between arsenic and iron in plant tissue when S. polyrhiza L. was exposed to As (III), DMAA, and MMAA.As (V) is primarily adsorbed on precipitated iron oxides on the roots of aquatic plants and deposited by a physicochemical adsorption process, according to the findings.
4.2 Arsenic metabolism and detoxification in aquatic macrophytes
Arsenic occurs primarily as As (V) in an oxic environment and as As (III) in a reduced environment [64]. In plants, As (V) and phosphate share the same transporter, while As(III) enters plant cells through NIPs’aquaporins [57, 64]. Because of their distinct molecular properties, these two types of arsenic elicit different biochemical responses in aquatic plants [71]. As (V) has no affinity for thiol ligands, while As(III) has a strong affinity for peptides with sulfhydryl (-SH) groups, such as glutathione (GSH) and phytochelatins (PCs) [64, 72]. Even though plants had been exposed to As, arsenic speciation in plant tissues indicates that arsenic is primarily present in the As(III) oxidation state (V).This suggests that As(V) is effectively reduced to As(III) in plant cells after uptake, and that most plants have high As(V) reduction competence [64]. The reduction of As(V) to As(III) is mediated by GSH [73] and by enzyme [74], which is thought to be a detoxification mechanism of the plants. As(V) and As(III) have been shown to generate reactive oxygen species (ROS) within cells when they are taken up [75], and plants counteract the generation of ROS by various enzymes and cellular compounds [76]. The GSH can act as an antioxidant and is required for the synthesis of Phytochelatins which are required for metalloid chelation [71].
The mechanism of arsenic accumulation and detoxification was studied by many others in aquatic plant H. verticillata [57, 71]. In the presence of As (III) or As(V), H. verticillata enhanced the biosynthesis of thiols such as PCs, and increased antioxidant enzyme activity. Although the levels of thiolic compounds such as NP-SH, cysteine, GSH, and oxidized glutathione (GSSG) were significantly enhanced in H. verticillata upon exposure to both As(III) and As(V), As(III) was found to enhance the activities of cysteine synthase and c-glutamylcysteine synthetase and the amount of cysteine and GSH to higher levels than As(V) . The analysis of PCs indicates that the accumulation of PC1 and PC2 in H. verticillata was enhanced with the increase of both As(III) and As(V) concentrations [71]. Thus, during As (III) and As(V) stress, phytochelatins and antioxidant systems in H. verticillata react differently, which is considered to be the plant’s detoxification mechanism.
5. Biotechnological interventions for phytoremediation
Plants have been utilized for phytoremediation of toxic metals and metalloids, however due to heavy metal phytotoxicity to plants; this process has been slow and largely rendered ineffective [77]. Natural heavy metal hyperaccumulators are also available, however, they are limited to specific geo-climatic conditions and also lack the crucial biomass required for efficient phytoremediation. Phytoremediation has a lot of potential using genetic engineering technologies to improve plant tolerance and heavy metal accumulation. Furthermore, various new studies using omics technologies such as genomics, transcriptomics, proteomics, and metabolomics to elucidate the genetic determinants and pathways involved in heavy metal and metalloid tolerance in plants have been identified. Presently there are three main biotechnological approaches for the phytoremediation of heavy metals and metalloids are currently being used to engineer plants for phytoremediation of heavy metals and metalloids: (1) manipulating metal/metalloid transporter genes and uptake systems; (2) enhancing metal and metalloid ligand production; (3) conversion of metals and metalloids to less toxic and volatile forms [78] (Figure 3).
Figure 3.
Potential biotechnological strategies for phytoremediation. Heavy/toxic metals can be mobilized and transported (influx) into roots through plasma membrane transporters. They can then be transported (efflux) out of the roots into the xylem and translocated into the shoots. At this stage, plant tolerance to toxic elements may be enhanced through manipulation of influx/efflux transporters or by increasing the levels of ligands/chelators. Volatilization of the toxic elements can be achieved through enzymes that modify these toxic elements. Chelators or efflux transporters can also be used to export the toxic elements out of the cytosol and into vacuoles or the cell wall. Adapted from Dhankher et al. (2011).
5.1 Manipulating metal/metalloid transporter genes and uptake system
Enhanced heavy metal tolerance and bioaccumulation has been attained in different plant species by genetic manipulation of metal transporter genes. For example, the overexpression of full length NtCBP4 (plasma membrane channel protein) in Nicotiana tabacum showed Pb2+ hypersensitivity and enhanced accumulation of Pb2+ in the genetically manipulated plants. However, the overexpression of a truncated version of NtCBP4 generated by deletion of its C-terminal, calmodulin- binding domain and part of the putative cyclic nucleotide- binding domain showed improved tolerance to Pb2+ and less accumulation of Pb2+ [79]. Nicotiana tabacum plants expressing CAX2 (calcium exchanger 2) gene accumulated more Ca2+, Mn2+ and Cd2+ and also showed enhanced tolerant to elevated Mn2+. It was also observed that overexpression of CAX2 gene in Nicotiana tabacum increased Mn2+ and Cd2+ transport in the root tonoplast vesicles in the transgenic plants [80]. Moreover, T-DNA mutants of the Arabidopsis CNGC1 (cyclic nucleotide- gated ion channel 1) gene, that encodes a homologous protein to NtCBP4, also showed Pb2+ hypersensitivity and enhanced accumulation of Pb2+ in the genetically manipulated plants. These findings suggest that NtCBP4 and AtCNGC1 play an important role in the transport pathway of Pb2+ [79, 81]. The overexpression of yeast YCF1 (Yeast Cadmium Factor 1) gene in Arabidopsis thaliana resulted in enhanced accumulated higher amounts and tolerance to Pb2+ and Cd2+ metals in plants [82].
Recent research findings have revealed arsenite is transported in plants by proteins belonging to the aquaporins [83, 84]. It is observed that in efficient arsenic hyperaccumulators such as Pteris vittata has highly well-organized system of arsenic translocation from root to shoot tissues [85, 86], However, most non-hyperaccumulators show low mobility rate compared to P. vittata, also variable Arsenic mobility rate is observed among different plant species, suggesting that it is controlled by genes. Arsenic loading to the xylem is a critical stage in arsenic translocation from root to shoot, however it is a poorly known mechanism. Ma et al. [87, 88] has identified and characterized Lsi2 gene encoding an efflux protein, plays an important role in loading arsenite into the xylem. Mutation in Lsi2 gene caused about 50% reduction in arsenic accumulation in the shoot. The Lsi2 gene is a homolog of the E. coli ArsB gene, an As (III)/H+ exchanger that confers bacterial arsenite tolerance [89].
Genome-wide gene expression analysis in Oryza sativa roots treated with different heavy metals and metalloids; As(V), Cr(VI), Pb, and Cd, showed numerous differentially expressed genes as well as unique genes. Various genes belonging to different transporter families were identified [90]. Recently Wang et al. [91], has identified genes for Cu tolerance in the Paeonia ostii with the help of de novo transcriptome sequencing approach. Such genes may further be transferred to crop plants for enhancing heavy metal tolerance. Therefore, strategies of developing transgenic plants for arsenic (As) phytoremediation include enhancing plant uptake for phytoextraction, decreasing plant uptake, improving the plants’ tolerance to As contamination, and increased methylation for enhanced food safety.
5.2 Enhancing metals and metalloids ligand production
Complexation of Arsenic with phytochelatins (PCs), or metallothionein (MTs) or glutathione (GSH) is an proficient way to detoxify As(III), since these complexes are sequestered in the vacuoles, this process is catalyzed by the homologs of multidrug resistance proteins (MRPs) [92, 93]. Enhancing the accumulation or synthesis of PCs and/or GSH and/or MTs may be one way to increase phytoremediation of arsenic. The overexpression of PCS in Brassia juncea enhanced its tolerance to arsenic but no significant increase arsenic accumulation was observed, this may be due to the fact that PC synthesis is also limited by the production of GSH [94]. The overexpression of AtPCS1 and GSH1genes, that encode g-glutamylcysteine synthetase (g-ECS), the rate-limiting step in GSH biosynthesis, individually in Arabidopsis thaliana increased both arsenic tolerance and as well as accumulation [95].
Arsenic (As) tolerance in plants can also be increased by modifying GSH and PCs. Dhankher et al. [96] transferred and co-expressed two bacterial genes, E. coli arsenate reductase (arsC) and γ-glutamylcysteine synthetase (γ-ECS), in Arabidopsis thaliana, the transgenic plants grown in the presence of 125 μM sodium arsenate accumulated threefold more arsenic in the aboveground biomass and showed almost 17-fold higher biomass than wild type WT plants. The overexpression of AtPCS1 under constitutive promoter in A. thaliana enhanced tolerance to arsenate but failed to enhance arsenic accumulation [97]. These studies showed that manipulation of genes for increasing the production of metal chelation agents hold great potential for improving heavy metal and metalloid tolerance and accumulation in plants.
The de novo transcriptome sequencing analysis in Raphanus sativus L. roots under cadmium stress was carried out to discover differentially expressed genes and microRNAs (miRNAs) involved in Cd-responsive regulatory pathways. Various candidate genes encoding PCs, GSHs, and MTs; and other genes belonging to zinc iron permease (ZIPs) and ABC transporters were identified [98]. Likewise, in de novo transcriptome analysis in radish roots under chromium stress, showed that 1561 unigenes down-regulated and 1424 unigenes were up-regulated, various transcription factors such as Chromium stress-responsive genes involved in chelate compounds, signal transduction and antioxidant biosynthesis were discovered [99]. Such candidate genes can further be transferred into the crop plants to enhance heavy metal tolerance as well as accumulation.
5.3 Conversion of metals and metalloids to less toxic and volatile forms
There are several reports for developing phytoremediation strategies for heavy metals with the help of biotechnological interventions by conversion of these metals to less toxic and volatile forms. It is observed that many organisms, including bacteria, fungi, and animals, methylate arsenic. Methylated arsenic have been discovered in several plant species, including rice grain [100, 101], and suggest that this is the process is a result of endogenous methylation by the plants themselves. The final product of this pathway is the gas trimethylarsine (TMAs(III)), that can be volatilized from the plant. Qin et al. [102] have cloned a gene encoding an As(III)-S-adenosylmethionine methyltransferase (arsM) from the soil bacterium Rhodopseudomonas palustris. Expression of the arsM gene in an arsenic-sensitive strain of E. coli that resulted in the biosynthesis of several methylated forms of arsenic, including volatile TMAs(III) and conferred arsenic tolerance in the plants. These findings show that the expression of the single methyltransferase (arsM) gene is sufficient to produce both volatilization and tolerance to arsenic (As). A gene for an ArsM homolog in a primitive plant, the eukaryotic alga Cyanidioschyzon merolae has been idenfied [103]. Cells expressing CmArsM methylates As(III), as like the purified enzyme. In a rice microarray study, a putative gene annotated as a methyltransferase was found to be upregulated upon exposure to arsenate in the growth solution [104]. These findings indicate the possibility of engineering arsenic volatilization for the phytoremediation of arsenic-contaminated water and soil and also to improve the safety of the food supply.
6. Conclusions
Contamination of soils and water by arsenic is one the serious threat for food security and human health in throughout the world. Some severe skin and other diseases occur due to continuous consumption of As contaminated foods and water. This necessitates a suitable technology to handle arsenic contaminated water carefully, so that above mentions points can be satisfied. Phytoremediation of arsenic contaminated water by aquatic and semi aquatic weeds offers low cost, economically feasible and eco-friendly technology to remove arsenic from contaminated water for long term. Some weeds have tremendous potential to accumulate higher amount of arsenic in their plant parts such as Eichhornia crassipes, Hydrilla verticillata, Spirodella polyrhiza, Arundo donax and Vetivaria spp. More specifically semi aquatic weeds like Arundo donax and Vetivaria sp. (perennial) can be used with in combination with Eicchornia, Spirodella and Hydrilla to remove arsenic more efficiently from treatment tanks or constructed wetland system. Although management of plant biomass will be another concern for disposal, but these plant materials can be used for making fiber (water hyacinth), handcraft items (Arundo and Typha stems) and biofuel purpose. Moreover, with advancement of molecular genetics in future As tolerance genes can be transferred to food crops (specially rice) which can store huge amount of As in their roots or very low transfer co-efficient from root to grain so that transgenic rice crops will able to grow using As contaminated water and contribute in food security in upcoming days.
\n',keywords:"Arsenic, Phytoremediation, Weed",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/77930.pdf",chapterXML:"https://mts.intechopen.com/source/xml/77930.xml",downloadPdfUrl:"/chapter/pdf-download/77930",previewPdfUrl:"/chapter/pdf-preview/77930",totalDownloads:139,totalViews:0,totalCrossrefCites:0,dateSubmitted:"June 7th 2021",dateReviewed:"June 17th 2021",datePrePublished:"August 7th 2021",datePublished:"April 20th 2022",dateFinished:"August 7th 2021",readingETA:"0",abstract:"Arsenic (As) is the one the most toxic element present in earth which poses a serious threat to the environment and human health. Arsenic contamination of drinking water in South and Southeast Asia reported one of the most threatening problems that causes serious health hazard of millions of people of India and Bangladesh. Further, use of arsenic contaminated ground water for irrigation purpose causes entry of arsenic in food crops, especially in Rice and other vegetable crops. Currently various chemical technologies utilized for As removal from contaminated water like adsorption and co-precipitation using salts, activated charcoal, ion exchange, membrane filtration etc. are very costly and cannot be used for large scale for drinking and agriculture use. In contrast, phytoremediation utilizes green plats to remove pollutants from contaminated water using various mechanisms such as rhizofiltration, phytoextraction, phytostabilization, phytodegrartion and phytovolatilization. A large numbers of terrestrial and aquatic weed flora have been identified so far having hyper metal, metalloid and organic pollutant removal capacity. Among the terrestrial weed flora Arundo donax, Typha latifolia, Typha angustifolia, Vetivaria zizinoids etc. are the hyper As accumulator. Similarly Eicchornea crassipes (Water hyacinth), Pistia stratiotes (water lettuce), Lemna minor (duck weed), Hyrdilla verticillata, Ceratophyllum demersum, Spirodella polyrhiza, Azola, Wolfia spp., etc. are also capable to extract higher amount of arsenic from contaminated water. These weed flora having As tolerance mechanism in their system and thus remediate As contaminated water vis-à-vis continue their life cycle. In this chapter we will discuss about As extraction potential of various aquatic and semi aquatic weeds from contaminated water, their tolerance mechanism, future scope and their application in future world mitigating As contamination in water resources.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/77930",risUrl:"/chapter/ris/77930",signatures:"Dibakar Roy, Dasari Sreekanth, Deepak Pawar, Himanshu Mahawar and Kamal K. Barman",book:{id:"10681",type:"book",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,fullTitle:"Biodegradation Technology of Organic and Inorganic Pollutants",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",publishedDate:"April 20th 2022",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-896-6",printIsbn:"978-1-83968-895-9",pdfIsbn:"978-1-83968-897-3",isAvailableForWebshopOrdering:!0,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"346613",title:"Dr.",name:"Dibakar",middleName:null,surname:"Roy",fullName:"Dibakar Roy",slug:"dibakar-roy",email:"dibakar499176@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"351033",title:"Dr.",name:"Kamal K.",middleName:null,surname:"Barman",fullName:"Kamal K. Barman",slug:"kamal-k.-barman",email:"barmankk@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"422032",title:"Dr.",name:"Dasari",middleName:null,surname:"Sreekanth",fullName:"Dasari Sreekanth",slug:"dasari-sreekanth",email:"sreekanthplantsciences@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"422033",title:"Dr.",name:"Deepak",middleName:null,surname:"Pawar",fullName:"Deepak Pawar",slug:"deepak-pawar",email:"pawardv1@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"422035",title:"Dr.",name:"Himanshu Mahawar",middleName:null,surname:"Himanshu Mahawar",fullName:"Himanshu Mahawar Himanshu Mahawar",slug:"himanshu-mahawar-himanshu-mahawar",email:"himanshu.mahawar@icar.gov.in",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Phytoremediation pathways",level:"1"},{id:"sec_3",title:"3. Potential of various aquatic plants for phytoremediation",level:"1"},{id:"sec_3_2",title:"3.1 Phytoremediation by free floating aquatic weeds",level:"2"},{id:"sec_4_2",title:"3.2 Phytoremediation of arsenic by semi aquatic weeds",level:"2"},{id:"sec_5_2",title:"3.3 Phytoremediation by submerged aquatic weeds",level:"2"},{id:"sec_7",title:"4. Mechanisms of arsenic uptake and detoxification in aquatic weeds",level:"1"},{id:"sec_7_2",title:"4.1 Mechanisms of arsenic uptake in aquatic macrophytes",level:"2"},{id:"sec_7_3",title:"4.1.1 Active uptake through phosphate uptake transporters",level:"3"},{id:"sec_8_3",title:"4.1.2 Passive uptake through aquaporins/aquaglyceroporins",level:"3"},{id:"sec_9_3",title:"4.1.3 Physicochemical adsorption on root surfaces",level:"3"},{id:"sec_11_2",title:"4.2 Arsenic metabolism and detoxification in aquatic macrophytes",level:"2"},{id:"sec_13",title:"5. Biotechnological interventions for phytoremediation",level:"1"},{id:"sec_13_2",title:"5.1 Manipulating metal/metalloid transporter genes and uptake system",level:"2"},{id:"sec_14_2",title:"5.2 Enhancing metals and metalloids ligand production",level:"2"},{id:"sec_15_2",title:"5.3 Conversion of metals and metalloids to less toxic and volatile forms",level:"2"},{id:"sec_17",title:"6. 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International journal of environmental studies. 2008 Aug 1;65(4):587-94'},{id:"B62",body:'Caporale AG, Sarkar D, Datta R, Punamiya P, Violante A. Effect of arbuscular mycorrhizal fungi (Glomus spp.) on growth and arsenic uptake of vetiver grass (Chrysopogon zizanioides L.) from contaminated soil and water systems. Journal of soil science and plant nutrition. 2014 Dec;14(4):955-72'},{id:"B63",body:'Tripathi RD, Srivastava S, Mishra S, Singh N, Tuli R, Gupta DK, Maathuis FJ. Arsenic hazards: strategies for tolerance and remediation by plants. Trends in biotechnology. 2007 Apr 1;25(4):158-65'},{id:"B64",body:'Zhao FJ, Ma JF, Meharg AA, McGrath SP. Arsenic uptake and metabolism in plants. New Phytologist. 2009 Mar;181(4):777-94'},{id:"B65",body:'Mkandawire M, Lyubun YV, Kosterin PV, Dudel EG. Toxicity of arsenic species to Lemna gibba L. and the influence of phosphate on arsenic bioavailability. Environmental Toxicology: An International Journal. 2004 Feb;19(1):26-34'},{id:"B66",body:'Abedin MJ, Feldmann J, Meharg AA. Uptake kinetics of arsenic species in rice plants. Plant physiology. 2002 Mar 1;128(3):1120-8'},{id:"B67",body:'Meharg AA, Jardine L. Arsenite transport into paddy rice (Oryza sativa) roots. New phytologist. 2003 Jan;157(1):39-44'},{id:"B68",body:'Ma JF, Yamaji N, Mitani N, Xu XY, Su YH, McGrath SP, Zhao FJ. Transporters of arsenite in rice and their role in arsenic accumulation in rice grain. Proceedings of the National Academy of Sciences. 2008 Jul 22;105(29):9931-5'},{id:"B69",body:'Benga G. Water channel proteins (later called aquaporins) and relatives: past, present, and future. IUBMB life. 2009 Feb;61(2):112-33'},{id:"B70",body:'Robinson B, Kim N, Marchetti M, Moni C, Schroeter L, van den Dijssel C, Milne G, Clothier B. Arsenic hyperaccumulation by aquatic macrophytes in the Taupo Volcanic Zone, New Zealand. 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Enhanced arsenate reduction by a CDC25-like tyrosine phosphatase explains increased phytochelatin accumulation in arsenate-tolerant Holcus lanatus. The Plant Journal. 2006 Mar;45(6):917-29'},{id:"B75",body:'Meharg AA, Hartley-Whitaker J. Arsenic uptake and metabolism in arsenic resistant and nonresistant plant species. New Phytologist. 2002 Apr;154(1):29-43'},{id:"B76",body:'Mittler R. Oxidative stress, antioxidants and stress tolerance. Trends in plant science. 2002 Sep 1;7(9):405-10'},{id:"B77",body:'Dhankher OP, Pilon-Smits EA, Meagher RB, Doty S. Biotechnological approaches for phytoremediation. InPlant biotechnology and agriculture 2012 Jan 1 (pp. 309-328). Academic Press'},{id:"B78",body:'Kotrba P, Najmanova J, Macek T, Ruml T, Mackova M. Genetically modified plants in phytoremediation of heavy metal and metalloid soil and sediment pollution. Biotechnology advances. 2009 Nov 1;27(6):799-810'},{id:"B79",body:'Sunkar R, Kaplan B, Bouché N, Arazi T, Dolev D, Talke IN, Maathuis FJ, Sanders D, Bouchez D, Fromm H. Expression of a truncated tobacco NtCBP4 channel in transgenic plants and disruption of the homologous Arabidopsis CNGC1 gene confer Pb2+ tolerance. The Plant Journal. 2000 Nov;24(4):533-42'},{id:"B80",body:'Hirschi KD, Korenkov VD, Wilganowski NL, Wagner GJ. Expression of Arabidopsis CAX2 in tobacco. Altered metal accumulation and increased manganese tolerance. Plant physiology. 2000 Sep 1;124(1):125-34'},{id:"B81",body:'Zeng H, Xu L, Singh A, Wang H, Du L, Poovaiah BW. Involvement of calmodulin and calmodulin-like proteins in plant responses to abiotic stresses. Frontiers in plant science. 2015 Aug 11;6:600'},{id:"B82",body:'Song WY, Sohn EJ, Martinoia E, Lee YJ, Yang YY, Jasinski M, Forestier C, Hwang I, Lee Y. Engineering tolerance and accumulation of lead and cadmium in transgenic plants. Nature biotechnology. 2003 Aug;21(8):914-9'},{id:"B83",body:'Bienert GP, Thorsen M, Schüssler MD, Nilsson HR, Wagner A, Tamás MJ, Jahn TP. A subgroup of plant aquaporins facilitate the bi-directional diffusion of As (OH) 3 and Sb (OH) 3 across membranes. BMC biology. 2008 Dec;6(1):1-5'},{id:"B84",body:'Mosa KA, Kumar K, Chhikara S, Mcdermott J, Liu Z, Musante C, White JC, Dhankher OP. Members of rice plasma membrane intrinsic proteins subfamily are involved in arsenite permeability and tolerance in plants. Transgenic research. 2012 Dec 1;21(6):1265-77'},{id:"B85",body:'Xu XY, McGrath SP, Zhao FJ. Rapid reduction of arsenate in the medium mediated by plant roots. New Phytologist. 2007 Nov;176(3):590-9'},{id:"B86",body:'Duan GL, Zhu YG, Tong YP, Cai C, Kneer R. Characterization of arsenate reductase in the extract of roots and fronds of Chinese brake fern, an arsenic hyperaccumulator. Plant Physiology. 2005 May 1;138(1):461-9'},{id:"B87",body:'Ma JF, Tamai K, Ichii M, Wu GF. A rice mutant defective in Si uptake. Plant Physiology. 2002 Dec 1;130(4):2111-7'},{id:"B88",body:'Ma JF, Tamai K, Yamaji N, Mitani N, Konishi S, Katsuhara M, Ishiguro M, Murata Y, Yano M. A silicon transporter in rice. Nature. 2006 Mar;440(7084):688-91'},{id:"B89",body:'Meng YL, Liu Z, Rosen BP. As (III) and Sb (III) uptake by GlpF and efflux by ArsB in Escherichia coli. Journal of Biological Chemistry. 2004 Apr 30;279(18):18334-41'},{id:"B90",body:'Dubey S, Shri M, Misra P, Lakhwani D, Bag SK, Asif MH, Trivedi PK, Tripathi RD, Chakrabarty D. Heavy metals induce oxidative stress and genome-wide modulation in transcriptome of rice root. Functional & integrative genomics. 2014 Jun;14(2):401-17'},{id:"B91",body:'Wang Y, Dong C, Xue Z, Jin Q, Xu Y. De novo transcriptome sequencing and discovery of genes related to copper tolerance in Paeonia ostii. Gene. 2016 Jan 15;576(1):126-35'},{id:"B92",body:'Lu YP, Li ZS, Rea PA. AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: isolation and functional definition of a plant ATP-binding cassette transporter gene. Proceedings of the National Academy of Sciences. 1997 Jul 22;94(15):8243-8'},{id:"B93",body:'Tommasini R, Vogt E, Fromenteau M, Hörtensteiner S, Matile P, Amrhein N, Martinoia E. An ABC-transporter of Arabidopsis thaliana has both glutathione-conjugate and chlorophyll catabolite transport activity. The Plant Journal. 1998 Mar;13(6):773-80'},{id:"B94",body:'Gasic K, Korban SS. Transgenic Indian mustard (Brassica juncea) plants expressing an Arabidopsis phytochelatin synthase (AtPCS1) exhibit enhanced As and Cd tolerance. Plant molecular biology. 2007 Jul;64(4):361-9'},{id:"B95",body:'Guo J, Dai X, Xu W, Ma M. Overexpressing GSH1 and AsPCS1 simultaneously increases the tolerance and accumulation of cadmium and arsenic in Arabidopsis thaliana. Chemosphere. 2008 Jul 1;72(7):1020-6'},{id:"B96",body:'Dhankher OP, Li Y, Rosen BP, Shi J, Salt D, Senecoff JF, Sashti NA, Meagher RB. Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and γ-glutamylcysteine synthetase expression. Nature biotechnology. 2002 Nov;20(11):1140-5'},{id:"B97",body:'Li Y, Dhankher OP, Carreira L, Lee D, Chen A, Schroeder JI, Balish RS, Meagher RB. Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity. Plant and Cell Physiology. 2004 Dec 15;45(12):1787-97'},{id:"B98",body:'Xu L, Wang Y, Liu W, Wang J, Zhu X, Zhang K, Yu R, Wang R, Xie Y, Zhang W, Gong Y. De novo sequencing of root transcriptome reveals complex cadmium-responsive regulatory networks in radish (Raphanus sativus L.). Plant Science. 2015 Jul 1;236:313-23'},{id:"B99",body:'Xie Y, Ye S, Wang Y, Xu L, Zhu X, Yang J, Feng H, Yu R, Karanja B, Gong Y, Liu L. Transcriptome-based gene profiling provides novel insights into the characteristics of radish root response to Cr stress with next-generation sequencing. Frontiers in plant science. 2015 Mar 31;6:202'},{id:"B100",body:'Williams PN, Price AH, Raab A, Hossain SA, Feldmann J, Meharg AA. Variation in arsenic speciation and concentration in paddy rice related to dietary exposure. Environmental science & technology. 2005 Aug 1;39(15):5531-40'},{id:"B101",body:'Zhu YG, Sun GX, Lei M, Teng M, Liu YX, Chen NC, Wang LH, Carey AM, Deacon C, Raab A, Meharg AA. High percentage inorganic arsenic content of mining impacted and nonimpacted Chinese rice. Environmental science & technology. 2008 Jul 1;42(13):5008-13'},{id:"B102",body:'Qin J, Rosen BP, Zhang Y, Wang G, Franke S, Rensing C. Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase. Proceedings of the National Academy of Sciences. 2006 Feb 14;103(7):2075-80'},{id:"B103",body:'Qin J, Lehr CR, Yuan C, Le XC, McDermott TR, Rosen BP. Biotransformation of arsenic by a Yellowstone thermoacidophilic eukaryotic alga. Proceedings of the National Academy of Sciences. 2009 Mar 31;106 (13):5213-7'},{id:"B104",body:'Norton GJ, Lou-Hing DE, Meharg AA, Price AH. Rice–arsenate interactions in hydroponics: whole genome transcriptional analysis. Journal of experimental botany. 2008 May 1;59(8):2267-76'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Dibakar Roy",address:"dibakar499176@gmail.com",affiliation:'
ICAR-Directorate of Weed Research, Jabalpur, India
ICAR-Directorate of Weed Research, Jabalpur, India
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ICAR-Directorate of Weed Research, Jabalpur, India
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6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Chapter, IntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
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7. MISCELLANEOUS
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7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
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7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
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7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
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7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
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7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
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7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
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Any modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
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7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
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7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Book Chapter:
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1. DEFINITIONS
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Corresponding Author: The Author of the Chapter who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author.
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Co-Author: All other Authors of the Chapter besides the Corresponding Author.
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IntechOpen: IntechOpen Ltd., the Publisher of the Book.
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Book: The publication as a collection of chapters compiled by IntechOpen including the Chapter. Chapter: The original literary work created by Corresponding Author and any Co-Author that is the subject of this Agreement.
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2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
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2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
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An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to publish, communicate to the public, reproduce, republish, transmit, sell, distribute and otherwise use and make available the Chapter in whole, partial or adapted from and/or incorporated in or in conjunction with other works, in electronic and print editions of the Publication and in derivative works and on any platform owned and/or operated by IntechOpen, throughout the world, in all languages, and in all media and formats now known or later developed.
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An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to create and store electronic archival copies of the Chapter, including the right to deposit the Chapter in open access digital repositories.
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An irrevocable, worldwide, royalty-free, perpetual, transferable, sublicensable, non-exclusive right to license others to reproduce, translate, republish, transmit and distribute the Chapter in whole, partial or adapted from and/or incorporated in or in conjunction with other works under the condition that the Corresponding Author and each Co-Author is attributed (currently this is carried out by publishing the Chapter under a Creative Commons Attribution 3.0 Unported License).
\n
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The aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
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2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Chapter but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Chapter as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
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The Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
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Subject to the license granted above, copyright in the Chapter and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
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Subject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Chapter.
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2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
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2.4 The Corresponding Author (on their own behalf and on behalf of each Co-Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Chapter as a consequence of IntechOpen's changes to the Chapter arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
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3. CORRESPONDING AUTHOR'S DUTIES
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3.1 When distributing or re-publishing the Chapter, the Corresponding Author agrees to credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Chapter.
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3.2 When submitting the Chapter, the Corresponding Author agrees to:
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Comply with all instructions and guidelines provided by IntechOpen;
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Produce the Chapter with all due skill, care and diligence, and in accordance with good scientific practice;
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Submit all the corrections in due time as defined during the publishing process schedule.
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The Corresponding Author will be held responsible for the payment of the Open Access Publishing Fees.
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All payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
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3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Chapter worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
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The Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
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3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
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4. CORRESPONDING AUTHOR'S WARRANTY
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4.1 The Corresponding Author represents and warrants that the Chapter does not and will not breach any applicable law or the rights of any third party and, specifically, that the Chapter contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Chapter is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Chapter has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
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The Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Chapter to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Chapter was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Chapter on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
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The Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
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4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
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5. TERMINATION
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5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co-Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
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In case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\n\n
6. INTECHOPEN’S DUTIES AND RIGHTS
\n\n
6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Chapter attributing it to the Corresponding Author and any Co-Author.
\n\n
6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Chapter and has the right to contact the Corresponding Author and any Co-Author until the Chapter is publicly available on any platform owned and/or operated by IntechOpen.
\n\n
6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Chapter, IntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\n
7. MISCELLANEOUS
\n\n
7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\n
7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\n
7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\n\n
7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
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7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
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7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
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Any modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\n
7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\n\n
7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
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Last updated: 2020-11-27
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Moreover, we review experimentally, analytically and numerically the types of heat pipes with their applications for electronic cooling in general and the computer cooling in particular. Summary tables that compare the content, methodology, and types of heat pipes are presented. Due to the numerous advantages of the heat pipe in electronic cooling, this chapter definitely leads to further research in computer cooling applications.",book:{id:"5150",slug:"electronics-cooling",title:"Electronics Cooling",fullTitle:"Electronics Cooling"},signatures:"Mohamed H.A. 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Sohel Murshed"}]},{id:"50699",title:"Heat Pipe and Phase Change Heat Transfer Technologies for Electronics Cooling",slug:"heat-pipe-and-phase-change-heat-transfer-technologies-for-electronics-cooling",totalDownloads:3538,totalCrossrefCites:4,totalDimensionsCites:4,abstract:"The heat pipe is a well-known cooling module for advanced electronic devices. The heat pipe has many applications, particularly in electronics and related area such as PC, laptop, display, artificial satellite, and telecommunication modules. The heat pipe utilizes phase change heat transfer inside enveloped structures, where the working fluid evaporates in heated zone, and vapor moves to the condenser, and the condensed liquid is pumped back through microporous structure call wick. The performance of applicability in electronics of heat pipe is strongly dependent on the geometry, working fluid, and microstructure of wick. Therefore, it is worth considering the theory and technologies related to heat pipes for advanced electronics cooling. According to the purpose of this chapter mentioned above, the author considers fundamental aspects regarding heat pipe and phase change phenomena. First, the working principle of heat pipe is introduced. Important parameters in heat pipe are considered, and theoretical model for predicting the thermal performance of the heat pipe is introduced. In addition, design method for heat pipe is presented. Finally, applications of heat pipe to electronics cooling are presented. This chapter covers knowledge and state-of-art technologies in regard to heat pipe and phase change heat transfer. For a reliable operation of future electronics that have ultra-high heat flux amounts to 1000 W/m2, heat pipe and phase change heat transfer are essential. This chapter provides the most valuable opportunity for all readers from industry and academia to share the professional knowledge and to promote their ability in practical applications.",book:{id:"5150",slug:"electronics-cooling",title:"Electronics Cooling",fullTitle:"Electronics Cooling"},signatures:"Chan Byon",authors:[{id:"178434",title:"Prof.",name:"Chan",middleName:null,surname:"Byon",slug:"chan-byon",fullName:"Chan Byon"}]},{id:"50421",title:"MEMS-Based Micro-heat Pipes",slug:"mems-based-micro-heat-pipes",totalDownloads:2745,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Micro-electro-mechanical systems (MEMS)-based micro-heat pipes, as a novel heat pipe technology, is considered as one of the most promising options for thermal control applications in microelectronic circuits packaging, concentrated solar cells, infrared detectors, micro-fuel cells, etc. The operating principles, heat transfer characteristics, and fabrication process of MEMS-based micro-grooved heat pipes are firstly introduced and the state-of-the-art of research both experimental and theoretical is thoroughly reviewed. Then, other emerging MEMS-based micro-heat pipes, such as micro-capillary pumped loop, micro-loop heat pipe, micro-oscillating heat pipe, and micro-vapor chamber are briefly reviewed as well. Finally, some promising and innovatory applications of the MEMS-based micro-heat pipes are reported. This chapter is expected to provide basic reference for future researches.",book:{id:"5150",slug:"electronics-cooling",title:"Electronics Cooling",fullTitle:"Electronics Cooling"},signatures:"Qu Jian and Wang Qian",authors:[{id:"178950",title:"Associate Prof.",name:"Jian",middleName:null,surname:"Qu",slug:"jian-qu",fullName:"Jian Qu"},{id:"184907",title:"Prof.",name:"Qian",middleName:null,surname:"Wang",slug:"qian-wang",fullName:"Qian Wang"}]},{id:"50240",title:"Theoretical Derivation of Junction Temperature of Package Chip",slug:"theoretical-derivation-of-junction-temperature-of-package-chip",totalDownloads:2371,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Junction temperature is the highest operating temperature of the actual semiconductor in an electronic device. In operation, junction temperature is higher than the case temperature and the temperature of the part’s exterior. The difference is equal to the amount of heat transferred from the junction to case multiplied by the junction-to-case thermal resistance. When designing integrated circuits, predicting and calculating the chip junction temperature is a very important task. This chapter describes how to derive the junction temperature from the thermal transport model.",book:{id:"5150",slug:"electronics-cooling",title:"Electronics Cooling",fullTitle:"Electronics Cooling"},signatures:"Professor Wei-Keng Lin",authors:[{id:"178475",title:"Prof.",name:"Wei-Keng",middleName:null,surname:"Lin",slug:"wei-keng-lin",fullName:"Wei-Keng Lin"}]}],onlineFirstChaptersFilter:{topicId:"554",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],testimonialsList:[]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
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\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n
\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
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