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Chen",coverURL:"https://cdn.intechopen.com/books/images_new/1295.jpg",editedByType:"Edited by",editors:[{id:"62462",title:"Prof.",name:"Clark",surname:"Chen",slug:"clark-chen",fullName:"Clark Chen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"80103",title:"Heavy Metals in Cosmetics",doi:"10.5772/intechopen.102406",slug:"heavy-metals-in-cosmetics",body:'A cosmetic is any product that is intended to be applied superficially to the human body to keep the treated part in good health. In this process, the cosmetic should not alter the physiological functioning of the body [1]. The use of cosmetics has been practiced since antiquity as apart from cleansing, cosmetics also beautify and alter the appearance hence making the individual more appealing and attractive. There are a plethora of ingredients that were and are used in the formulation of cosmetics. The general intended purposes of cosmetics have not changed throughout centuries and millennia, the formulation of these cosmetics has undergone significant transformations, some of which include the processing and the ingredients used for their formulation. The processing has changed from a domestic/small scale production to cater for a small number of individuals to industrial/large scale production to cater for a wider consumer population with the use of worldwide advertising and social media. On the other hand, the constitution of cosmetics has also changed with time. With industrialization and the use of petrochemically-derived substances, the cosmetic formulation changed from one based on natural products to one which is mainly based on petrochemicals. However, during these past decades, there was a change in the constitution of cosmetics, to include more natural ingredients, due to the great interest and concern by consumers.
As a consequence, the massive production of cosmetic products with a wide range of ingredients, has raised several health and safety concerns. Nowadays, cosmetics are generally regulated [2]. One major concern is that cosmetics overlap in use and functionality with topical medicines. Several regulatory bodies attempted to devise a proper definition for cosmetic products with the intent to segregate cosmetic products from topical medicinal products. Within the European Union (EU), Council Directive 93/35/EEC [3] amending Council Directive 76/768/EEC, a definition for cosmetic products was laid down in article 1 of the directive. In the first part of the definition, the external body parts which may be treated with cosmetics are mentioned. Other body parts are excluded and this eludes to the understanding that cosmetic products should not be applied to these other body parts. The second part is related to the ‘activities’ which are allowed for a product to be considered as a cosmetic. These distinguish cosmetics from topical medicinal products which are intended for the control or treatment of conditions or else in making a medical diagnosis [4]. However, whereas topical medicinal products are meticulously scrutinized before their placement on the market, cosmetics do not undergo rigorous testing. Nevertheless, for cosmetic products, the manufacturers, distributors and importers are responsible for the safety of cosmetic products being placed on the market [5]. The latter regulation also states clearly what ingredients are prohibited for their presence in cosmetic products. Amongst the prohibited ingredients several heavy metals are also included. Whereas some metals and their salts are completely prohibited (e.g., tin, arsenic, cadmium, nickel and lead), other metals and their salts are either allowed with a specific limit or else only specific salts for such metals are allowed (e.g., cobalt, chromium, gold, mercury and selenium amongst others). Such additions may not be intentional as the addition of some minerals may originate from a natural source. Heavy metals, such as cadmium (Cd), lead (Pb), nickel (Ni), arsenic (As) and mercury (Hg) were also detected in numerous other raw materials which can be used for the production of cosmetics considered as natural products. These include honey [6], argan oil [7], and olive oil [8] as well as citrus essential oils [9].
Because of this, some authorities also impose limits on the presence of certain metals in cosmetics. For example, The Cosmetic Ingredient Review Expert Panel established by Food and Drug Administration (FDA) in the USA issued limits on As (5 ppm), Pb (5 ppm) and other heavy metals (20 ppm) [10]. The World Health Organisation (WHO) set limits for Pb (10 ppm), Cd (0.3 ppm) and Hg (1 ppm). The EU’s limits for Pb, Cd and chromium are 0.5, 0.5 and 1.0 ppm, respectively, while the Canadian authorities set limits for Pb (10 ppm), Cd (3 ppm) and Hg (3 ppm) [11]. However, there tends to be inconsistency in the type of metals and the limits for the metals by different authorities. As a consequence, this lack of harmonization leads to confusion amongst authorities as regulators, several manufacturers as producers and the general population as consumers. Despite all this, several researchers investigated the potential presence of heavy metals in a wide range of products. This review aims at compiling a large number of studies related to the presence of heavy metals in cosmetics and their potential harm in human beings.
Heavy metals are elements that are primarily found in the d and p-blocks of the periodic table showing a metallic character and an ability to form salts. Some sources specify that heavy metal should have a high density [12]. Such metals include lead, cadmium, nickel, mercury and arsenic amongst others.
The main concern is that heavy metals are ubiquitous and are present in several matrices both living and non-living. Particularly in living matrices, heavy metals may interfere with beneficial metals some of the latter being replaced by heavy metals that would result in the erratic physiological functioning of bodily systems. This is not an issue related only to mammals and humans, but such erratic behavior, in terms of morbidity and mortality has been observed in other animals, such as insects [13], and also in plants. Some of these heavy metals accumulate in biological systems and one source for such accumulation is the daily and/or repeated use of cosmetic products such as face powders, lipsticks and eye shadows [2]. Some heavy metals are commonly found in cosmetics [14, 15, 16, 17, 18, 19, 20].
The absorption, distribution, metabolism, excretion and interaction of heavy metals with bodily systems are complex processes that are not yet fully understood. This is even more complex when considering that some cosmetics are applied and rinsed shortly after (such as toothpastes, shampoos and conditioners and cleansers), others are applied and allowed for a few minutes to hours (such as body creams, lotions and facial makeup) and those that are applied and remain in contact with the skin for several hours (such as nail polish and hair dyes). The kinetics and dynamics of metals present in these cosmetic products, vary significantly in their fate and their extent of effects [21].
With the application of cosmetic products, the mode of entry of heavy metals in the body is via dermal or topical application. These metals may have either topical and/or systemic effects in humans [22]. At the site of application, heavy metals may accumulate in the stratum corneum causing local effects, that may be exhibited as allergic contact dermatitis associated with an excess of a metal (such as Ni, cobalt and chromium) at the site [23, 24] because of their binding to keratin [22]. In the case of Ni, this metal has a high affinity to the histidine component of the filaggrin in the stratum corneum [25]. Although, the mechanism by which heavy metals damage the skin is not yet fully understood, it is believed that this may be provoked by the formation of free radicals and/or by an inflammatory effect [26]. It was discovered that metals may accumulate with repeated application of contaminated cosmetics. Consequently, such areas would serve as reservoirs and hence lead to long-term exposure of the individual to the metal, even when such cosmetics are no longer applied [27]. The exposure of the skin to heavy metals may extend the dermal inflammation to the systemic system [26]. Ni can only penetrate and reach the general circulation, when damage is provoked by other metals [28]. Other metals such as Hg, Pb and Cd may enter the general circulation through the skin layers and transported to various organs within the body [29, 30]. This permeation can occur via sweat glands and hair follicles. Besides direct contact, oral ingestion of heavy metals may occur by the application of cosmetic products either to the lips (e.g., lipstick, lip gloss and lip balms) or within the buccal cavity (toothpastes, mouthwashes and breathe sprays) or by hand to mouth transfer of any cosmetic applied to any body part [31]. Thinner facial skin is more permeable than skin elsewhere [32]. Several studies show that certain heavy metals (such as Pb, Hg and Cd) found in topical cosmetics are found in high concentrations in the blood, urine and internal organs of individuals who use cosmetics when compared to individuals who do not [33, 34, 35, 36, 37, 38, 39, 40]. Cosmetics that are applied directly to the skin may contain moisturizing agents that increase skin permeation that may allow the entry of xenobiotics, to which some heavy metals may be bound, into the general circulation [41]. Apart from the binding of heavy metals to exogenous substances [42], these may also bind to endogenous biological molecules, hence replacing the beneficial metals. These metals may bind to several functional groups such as the amine, carboxylic and thiol function groups present in several proteins, some of which have functional roles (such as enzymes), while others have structural roles (such as collagen, keratin, actin and myosin). These metals can also bind to nucleic acids which may lead to defective DNA and RNA synthesis that may result in carcinogenesis. The application of underarm products has been hypothetically associated with the possibility of breast cancer [43]. Therefore, heavy metals provoke several toxic effects at the cellular and molecular levels [44, 45].
Several authors reported the presence of heavy metals in cosmetic products. This review gives an insight into the presence and effects of the most notorious and underestimated heavy metals in cosmetics products. The metals under discussion are lead, cadmium, nickel, mercury and arsenic.
One of the most studied heavy metals is lead. Lead is not normally used for its potential properties but it is rather considered as a contaminant with serious effects on human health. When a lead comes in contact with vital organs, it is neurotoxic, nephrotoxic and hepatotoxic [46, 47] and may provoke effects also on the reproductive system [48]. Lead can also affect fetal development through its passage via the placenta [49, 50]. Some studies have shown that it is considered a potential carcinogen to humans [51]. It has been reported that the level of Pb in the blood of consumers who use eye cosmetics was threefold higher than that of non-consumers [52]. Lead is acquired from industrial dust and fumes, car emissions, industrial chemicals such as old paints and pesticides, and a burning of fossil fuels. Food contamination may occur from some of these sources. Authorities worldwide are in a continuous struggle to establish permissible limits for Pb. The World Health Organization established a limit of 10 ppm [53]. The permissible level according to [54] is 0.1 mg/l. The FDA established a maximum permissible content of 10 ppm for Pb in color additives for the manufacture of cosmetics using Good Manufacturing Practices [10]. However, in color additives, the Pb content should not exceed 20 ppm [55]. Lead and its salts are prohibited in any cosmetic product within the EU [5]. Health Canada established a limit of 10 ppm for lead in cosmetic products [11].
As shown in Tables 1–3, several researchers investigated the presence of lead in several cosmetic products. The lipstick group is one of the most widely investigated groups with over fifteen citations. Only one study reported the absence of Pb in lipsticks [67, 70] whereas three other studies reported negligible Pb content in lipsticks [56, 57, 58] as their lower limit. Four studies showed a significantly high lead content (73.1–3760 ppm) [14, 16, 18, 57]. Most studies reported a Pb content that is within the 20 ppm permissible limit established by the FDA [59]. Some studies also tried to establish any differences between the high- and low-priced lipsticks (0.06–0.106 ppm) [60]. Eyeshadows ranks second in terms of investigated groups for Pb content. Four studies reported negligible Pb content in eyeshadows [31, 71, 72, 73] as their lower end. Whereas some studies have reported low Pb content as their lower end, the higher end exceeded the 20 ppm limit established by FDA [16, 19, 61, 71, 74]. Other eye products include eyebrow pencils (0.109–18.60 ppm) [58, 62, 63] and mascaras (ND-12.51 ppm) [58, 59, 73], all within the 20 ppm limit established by the FDA. There is only one study that reported Pb levels of 61.218 ppm in mascaras [59]. Face products vary significantly in their Pb content. Make-up foundation and face powders contain negligible Pb content up to 190 ppm as reported by [61]. Other studies did not exceed a content of 22.57 ppm [60, 63, 64], although one study reported a maximum of 41 ppm [78]. Face washes exceed the FDA limit (24.06–40.61 ppm) [14] and face creams contain minimal content of Pb (0.77 ± 1.13 ppm) [62]. Cosmetic face paint is a potential threat to frequent consumers as reported levels go up to 16.6 ppm [79]. Most hair products do not pose a potential problem as reported for hair shampoos, conditioners and dyes [17, 62, 63, 64]. Only one study reported a level of 54.56 ppm in hair products [14]. Several studies investigated body products that are applied over a larger surface area than those mentioned previously. Beauty creams contain a considerable amount of Pb with levels reaching 50.39 ppm [14, 86]. Although, somebody lotions contain low Pb levels [62], one study shows also high Pb content in such products [61]. This same study also reports a high Pb level in skin-lightening creams (up to 43.04 ppm) alongside another study showing a maximum level of 143 ppm [89]. On the other hand, two studies show low Pb contents (<4.015 ppm) [60, 64]. Cleansers and lotions also contain low Pb levels (< 22.14 ppm) [14, 62, 64]. Products that are applied to the buccal cavity include toothpaste. These may pose a problem in addition to mucosal absorption, Pb can be also ingested and absorbed via the gastrointestinal tract. In some studies, the level of Pb in toothpaste is minimal (0.036 ppm) [80], however, in other studies, the highest levels were 12.04 ppm [81] and 18.092 ppm [21].
Pb | Cd | Ni | Hg | As | |
---|---|---|---|---|---|
Lipsticks | <DL-252.4 [14, 18, 45, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66] 0.27–3760 [16] | ND-60.20 [14, 18, 45, 56, 58, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69] | ND-22.8 [18, 45, 56, 60, 61, 62, 64, 66, 70] | <DL to 80.00 [58, 61, 62, 63] | 0.01–6.931 [58, 62, 63] |
Eye-shadows | <DL-81.5 [16, 19, 31, 58, 61, 62, 65, 71, 72, 73, 74] | <DL-55.59 [19, 58, 61, 62, 65, 71, 72, 74] | < 0.5–359.4 [19, 31, 61, 62, 71, 72, 74] | <DL-181.00 [58, 62] | <DL-1630 [58, 62, 75] |
Eyebrow pencils and eye liners | 0.109–61.22 [58, 59, 62, 63] | ND-1.12 [58, 62, 63] | 2.1–10.52 [62] | ND-67.42 [58, 62, 63] | ND-2.071 [58, 62, 63] |
Mascaras | ND-12.51 [58, 59, 73] | ND-0.034 [58] | ND-0.028 [76, 77] | ND-0.002 [58] | 0.050–1.656 [58] |
Make-up foundation | <DL to 190 [60, 61, 63, 64, 78] | <DL to 17 [45, 60, 61, 63, 64] | <DL to 13.1 [60, 61, 64] | 48.99–60.77 [63] | 0.12–1.0 [63] |
Face paints | 0.02–370 [79] | 0.01–19.2 [79] | 7.6 ppm [79] | ND-0.004 [69] | 0.125.0 [79] |
Face cream | ND-1.9 [62] | ND-0.37 [14, 62] | ND [70] | ND-1.27 [62] | ND-0.171 [62] |
Toothpaste | ND-18.092 [21, 80, 81] | ND-2.490 [80, 81, 82] | 0.025–18.535 [80, 81, 82] | ND-13.14 [81, 83] | 0.06–26.94 [83] |
The content of heavy metals in face products; cosmetics and face care products.
Pb | Cd | Ni | Hg | As | |
---|---|---|---|---|---|
Body lotions | <DL to 47.5 [61, 62] | ND [62] | ND-0.003 [62] | <DL to 47.5 [61, 62] | ND-0.007 [62] |
Hair shampoos and conditioners | 0.66–54.56 [14, 62] | ND [14, 62] | 0.01–0.06 [62] | ND-21.08 [62, 83] | 0.002–0.2 [62, 84] |
Cleansers | 0.04–22.14 [14, 62] | ND [14] | ND-0.08 [62] | ND-0.72 [62] | ND-0.009 [62] |
Lotions | 0.068–8.29 [64] | 0.007–2.13 [64] | 0.012–6.29 [64] | 18.98–19.02 [83] | 1.537–1.543 [83] |
Hair dyes and creams | 0.402–17.70 [17, 63, 64] | 0.001–1.11 [63, 64] | 0.081–4.167 [64] | 53.74–90.32 [63] | 0.16–0.71 [63] |
Tonic creams | 0.35–0.55 [85] | 0.35–0.55 [85] | 3.40–4.70 [85] | — | — |
Beauty cream | 14.38–50.39 [14, 86] | 2.40–6.27 [86] | 0.0175–5.09 [87, 88] | 47.17–124.8 [83] | 5.08–10.74 [83] |
The content of heavy metals in body products.
Pb | Cd | Ni | Hg | As | |
---|---|---|---|---|---|
Skin lightening creams | <DL-143 [21, 60, 61, 64, 89] | 0.1–1.276 [60, 64, 89] | 2.59–11.17 [60, 64] | <DL-126,000 [15, 53, 61, 70, 89, 90, 91, 92, 93, 94] | 0.7–12.30 [53, 89] |
Sunblock cream | ND-6.889 [62, 64] | ND-0.155 [62, 64] | ND-12.37 [62, 64] | ND-1.62 [62] | ND-0.01 [62] |
The content of heavy metals in face and body products.
Lead is considered as a contaminant that is present to different extents in various cosmetic preparations. Several authorities recognize Pb as a toxic metal by setting up limits for its presence in cosmetics.
Cadmium is one of the metals that has been used in cosmetics for its colored salts, ranging from deep yellow to orange [2]. It has been associated with several toxicities in humans, mainly attributed to its absorption after topical application of several cosmetics [49, 86, 95] though this is very low (0.5%). Topically, it may cause irritant dermatitis [96]. The main concern with Cd is that it tends to accumulate in human tissues and then release slowly into the general circulation. However, it normally binds to the keratin. Systemically, it mainly affects the skeletal, reproductive, metabolic [88], respiratory and renal systems [97, 98]. It has been associated with osteoporosis, diabetes, lung cancer and kidney damage [99]. It contributes also to skin ageing as it may provoke oxidative stress [25]. Despite of its presence in cosmetics, it may be found in several sources such as industrial wastes, agrochemicals (pesticides and fertilizers) and batteries. According to the WHO, the permissible limit for cadmium is 0.3 ppm [53]. The permissible level according to [54] is 0.06 mg/l. The oral limit for Cd is 0.09 μg/kg to 3 ppm as given by USP for nutritional supplements. Cadmium and its salts are prohibited in any cosmetic product within the EU [5]. Health Canada established a limit of 3 ppm for Cd in cosmetic products [11].
Cadmium is another metal, which is banned by several authorities but still found in several cosmetics, as reported by several researchers (Tables 1–3). One of the studies that reports the absence of Cd in lipsticks was conducted by [67]. Several other studies reported levels that were lower than 0.002 ppm and levels that reached content of 60.20 ppm. Despite this, only two studies showed levels of Cd higher than 5 ppm [65, 68]. Due to possible ingestion, lipstick use may be linked to systemic toxicity. A study established a difference between high-priced (0.34 ± 0.20 ppm) and low-priced (0.89 ± 0.58 ppm) lipsticks [60]. Although, eye shadows may contain the deep yellow to orange pigments more than lipsticks, the Cd content of eye shadows as reported by several researchers did not exceed 3 ppm [19, 58, 62, 63, 71, 72, 74]. However, levels of 8.89 ppm [71] and 55.59 ppm [65] were reported for eye shadows. Another eye make-up was reported to contain low Cd content by three studies. For eyebrow pencils, the maximum content of Cd was 1.12 ppm [63], whereas the content of Cd in mascaras was reported to be lower, i.e., 0.034 ppm [58]. Other facial cosmetics were also reported to contain a low amount of Cd, with levels less than 0.96 ppm [45, 60, 63, 64]. The highest level was expressed to be that of 17 ppm [61] in the make-up foundation. Similarly, Cd levels did not exceed 0.67 ppm and 0.37 ppm in face washes and face creams, respectively [14]. Tonic creams did not exceed a level of 0.55 ppm [85]. In face paints, the average level reported was 0.6 ppm [79]. Cadmium was also absent in hair shampoos and conditions, with levels being below the detection limit [14, 62]. Negligible Cd content was also present in hair dyes with levels not exceeding 1.11 ppm [63, 64]. Body cosmetics are also generally low in Cd with levels not exceeding 0.92 ppm in skin lightening creams [60, 64, 89], 0.121 ppm in sunblock creams [62, 64] and 2.13 ppm in lotions [64]. No cadmium was detected in body lotions [62] and cleansers [14]. The level of Cd in most toothpastes did not exceed 0.058 ppm [80, 81] but a maximum of 2.49 ppm was reported [82].
Although, Cd is considered one of the most common and noxious heavy metals, it seems that its use in cosmetics is very limited. It may be concluded that Cd presence in cosmetics is considered to be a contaminant rather than an ingredient, as a coloring agent.
Nickel is one of the metal impurities which is inevitably found in several natural ingredients used in cosmetic products. Most of the salts containing nickel are green in color, hence also its potential use as a colorant. However, nickel is considered to be a contact allergen that may provoke dermal sensitization, allergies, and dermatitis [100] by direct and often prolonged exposure. Persons have been diagnosed with Ni allergy due to its presence in topical cosmetic products and jewelry [101]. Nickel may also affect the respiratory system which may result in nasal and lung cancer [98]. Despite of the potential use of cosmetics to maintain the skin in a rejuvenating state, Ni in such products may lead to oxidative stress and hence promote skin aging [25]. This may be due to the overexpression of collagenases in the skin leading to the weakening of the skin matrix and a subsequent loss in elasticity [102]. The International Agency for Research on Cancer (IARC) has classified metallic Ni as a potential carcinogen to humans (Group 2B) and its compounds as carcinogenic (Group 1) [103]. Nickel may be found occurring naturally in soil and volcanic dust. This may be acquired from industrial dust and fumes. Due to the potential skin sensitization, limits for Ni presence in products have been proposed. Limits of 5 ppm [88] and 1 ppm [104] were suggested for certain household products and detergents, respectively. Likewise, in cosmetics, a Ni limit was also proposed particularly aimed for sensitized persons. Most “nickel-free” products on the market, contain less than 1 ppm of Ni [31, 105, 106]. The permissible level is 0.20 ppm according to [107] for oral consumption. Nickel and a number of its salts are prohibited in any cosmetic product within the EU [5]. These include nickel monoxide, dinickel trioxide, nickel dioxide, trinickel disulphide, tetracarbonynickel, nickel sulphide, nickel dihydroxide, nickel carbonate and nickel sulphate.
Due to its possible implications in allergenic reactions, the content of Ni in a number of cosmetic products was reported by a number of research groups (Tables 1–3). The risks associated with Ni intoxication is more possible with cosmetics that are potentially ingested. Lipsticks and lip products are amongst these candidates. Most lipstick products investigated by research groups rarely contained less than 0.20 ppm of Ni for oral consumption. Due to the short-term duration of lipstick on the lips, these products are applied frequently by consumers. This may pose a further exacerbation if ingested. The maximum levels in most studies range from 1.61 to 22.8 ppm of Ni in lipsticks [18, 45, 56, 61, 64, 66, 70]. However, in one study it was reported that the mean Ni content was 0.10 ± 0.14 ppm [62]. It was demonstrated that the price has no impact on Ni content of lipsticks (high-priced 8.24 ± 3.29 ppm and low-priced 5.15 ± 4.19 ppm) [60]. Oral consumption may be due to the accidental swallowing of toothpaste. Studies have shown the range of Ni content in most toothpaste is between 0.02 and 2.54 ppm [80, 81] but another study reported maximum levels of 18.535 ppm [82]. Dermal sensitization has been associated with eye cosmetic products. In this situation the 1 ppm threshold is applicable. Several studies have reported levels of Ni which exceed 1 ppm. Only two studies show that the minimum level of Ni in eye-shadows was less than 1 ppm [19, 31]. In several studies, maxima for Ni levels ranged between 4.133 and 359.4 ppm [61, 62, 71, 72, 74]. Nickel has been found in a green eye liner which provoked a form of contact dermatitis in a 47-year-old woman [76] whereas another study reported contact allergy to a Ni-containing mascara [77]. A study reported a mean Ni content of 6.31 ± 4.21 ppm in eyebrow pencils [62]. Most make-up foundation products seem to contain high amounts of Ni, quoting the minimum values above 3 ppm and the maximum values to 13.01 ppm [60, 64]. Only one study reported values being less than the detection limit [61]. In a study on face paints, the average Ni content was 7.6 ppm [79]. However, in other facial formulations such as face washes and creams, the content was reported to be very low with a mean of 0.04 ± 0.11 ppm [14] or not detectable [70] for these formulations respectively. Hair products are of no major concern, as the levels in shampoos and conditions do not exceed 0.06 ppm whereas the highest content of Ni in hair dyes is 4.167 ppm [64]. Body products vary in Ni content. In general, Ni does not exceed 12.37 ppm, but the 1 ppm of Ni is exceeded for most products that include skin lightening creams, sun blocks, tonic creams and body creams [60, 64, 85, 87, 88]. Body lotions and cleansers seem to contain very low Ni contents (<0.08 ppm) [62].
Whereas Ni in mascaras and eye shadows has been implicated in its involvement in allergic chronic dermatitis, several studies have reported that Ni allergy cannot be considered as the main risk factor in patients reporting eye-lid dermatitis [108].
Mercury is one of the heavy metals that is widely used in cosmetic formulations. Although, mercury is known as a shiny, silvery, dense liquid, it may occur in various inorganic and organic compounds. In the inorganic form, such as ammoniated Hg, it is used for its skin lightening properties, whereas in the organic form, such as phenyl mercuric and ethyl mercuric salts, it is used as a preservative in mascaras and eye makeup cleansing products [90, 109]. After dermal application, Hg penetrates through the skin via the hair follicles and sweat glands [29, 96]. During this process, part of the Hg is reduced to the metallic form that accumulates in the skin tissue. Hg blocks tyrosinase in situ, inhibiting the melanin-forming enzyme [110], hence its use in skin-lightening creams [22]. Only one study mentioned that cream had the abbreviation ‘precip blanc’ on the label, which should suggest that this product contains Hg [36]. Systemically, Hg may exhibit a range of signs which include vomiting, nausea and kidney damage, central nervous sytstem effect which include irritability, tremors, weakness, nervousness, fatigue and memory loss. It may affect also the sensorial systems, that is, loss in hearing, taste and vision. Finally, high Hg content may lead to death [111, 112]. In some instances, following dermal absorption and systemic uptake, Hg may induce autoimmune glomerulonephritis. Studies reveal significant accumulation of mercury in several organs and body fluids, such as hair (22.5 ppm, twice that in non-cosmetic users), blood (up to 233 nmol/l, more than four times than that in non-cosmetic users] and urine (up to 2531 nmol/day, fifty times more than that in non-cosmetic users) [39, 91, 113, 114].
Mercury is a metallic element that is naturally occurring in the environment and its compounds are the most common form that exists naturally in the environment. Due to its ubiquity, several authorities issued limitations for Hg use. For instance, the FDA restricts its use and is regulated in cosmetic products. The FDA allows a maximum level of 1 ppm of Hg in mercury-contaminated lead acetate when used as a colour in cosmetics [10]. Within the European Union, mercury and its compounds are not allowed in cosmetics, whereas phenyl mercuric salts are only allowed as preservatives in eye care products at a maximum allowable level of 70 ppm [5] whereas in the US it is allowed up to a level of 65 ppm by weight [10]. Health Canada allows a maximum Hg content of 1 ppm in cosmetics [11].
The main emphasis of analysis by researchers was conducted on skin-lightening creams due to their interaction with melanin metabolism. Very few studies report levels below the 3 ppm threshold [15, 53, 70] (Tables 1–3). Other studies reveal values up to 126,000 ppm [61, 89, 90, 91, 92, 93]. Although, in some lipstick products, the Hg content was below the detection limit [58, 61, 62], some of these same studies and others reveal contents up to 80 ppm [63]. The status of Hg contamination in eye cosmetic products varies significantly with levels of up to 181 pm in eye shadows [58, 62], 67.42 ppm in eyebrow pencils [58, 62, 63] but levels of up to 0.002 ppm in mascaras [58]. Apart from the make-up foundation where levels of Hg reach a maximum level of 60.77 ppm [63], other face products contain minimal amounts of Hg, such as face creams (0.09 ± 0.37 ppm [62]), sunblock creams (0.41 ± 1.21 ppm [62]) and face paints (<0.004 ppm [69]). In some studies, it was reported that the content of Hg in hair products is below the detection limit [62] whereas in other studies, it reached a maximum of 90.32 ppm [63, 83]. Body care products such as body lotions and cleansers contain varied amounts of Hg [62], with products from the first group with contents up to 47.5 ppm [61]. In some beauty creams, the Hg level reached a maximum of 124.8 ppm [83]. The presence of mercury in toothpaste has not been widely investigated, but in two studies, the Hg level was reported to reach a maximum of 13.14 ppm [81, 83].
As can be concluded from these studies, Hg is one of the least detected heavy metals in most cosmetics [22], but not in skin-lightening products. Mercury is found intentionally in face and skin care products rather than in products for purely cosmetic use. Apart from skin-lightening properties, Hg compounds are claimed to reduce and remove freckles, treat acne, and prevent and remove wrinkles [22].
Arsenic is a metalloid that is present ubiquitously as a major contaminant in the environment. Although, it is redox inactive, its target functional groups are sulfydryl groups on proteins which may lead to the depletion of glutathione [115], an essential antioxidant of an amino acid origin, which prevents damage of cellular components caused by radicals and heavy metals. On long-term dermal exposure, As can cause hyperpigmentation and keratosis
In general, several studies reveal that As is not a significant contaminant and levels of this metalloid rarely exceed the 3 ppm limit (Tables 1–3). In lipsticks, although most studies report a level of up to 0.34 ppm [62, 63], a study reported a maximum level of 6.931 ppm of As [58]. In eye cosmetics, the maximum permissible limit is rarely exceeded. In general, eye shadows, eyebrow pencils and mascaras do not contain As levels more than 3.704, 2.071 and 1.656 ppm, respectively [58, 62, 63]. However, in a study, it was reported that in kohl, there was an alarming presence of As (810–1630 ppm). Kohl is an ancient eye cosmetic still used nowadays [75]. The danger with kohl is not solely because of its use as a cosmetic but there are claims that falsely indicating its use for the treatment of eye conditions. Apart from the presence of As in kohl, other face cosmetics, such as foundations and creams contain minimal quantities of As, reported as up to 1.0 and 0.171 ppm, respectively [62, 63]. Less commonly used products include face paints particularly used by opera actors in China. Levels of As reach a maximum of 25 ppm [79]. Shampoos, conditioners and dyes used on the hair contain low As concentrations (<0.71 ppm) [62, 63, 94]. Likewise, in a study, the As content for cleansers and sunblocks does not exceed 0.010 ppm [62] but higher levels were reported for body lotions (1.543 ppm) [83]. There are some concerns with skin-lightening creams as some exceed the 3 ppm threshold [53, 89] and other creams with levels up to 10.74 ppm [83]. In some toothpaste, the As content was 26.94 ppm [83]. Most likely, As is present as a contaminant with other heavy metals used for this purpose. In spite of these findings, As is one of those elements that is rarely found in cosmetics [22]. However, its presence may raise concerns particularly in legal products that are used on a long-term basis and in illegal cosmetic products on the underground market.
The studies discussed in the previous sections highlight the importance of specific metals as contaminants and additives in cosmetic products. To determine any particular relationships between formulations, a multi-variate meta-analysis was carried out using Spearman correlation and Principal Component Analysis, taking into account the maximum levels obtained for the various cosmetic formulations. Pearson correlation statistics (Table 4) reveal a relationship between all five metals (r > 0.466). Two latent factors had an eigenvalue greater than 1, which together explained 80.54% of the total variance. The factor loadings demonstrated the different groups of variables (Figure 1). Factor 1, displayed on the horizontal axis, weighed heavily on Pb, Cd, Ni and As with lipsticks, eye shadows, face paints, make-up foundation and skin lightening creams exhibiting high levels of these metals. These formulations were discriminately different from the rest. On the other hand, F2, displayed on the vertical axis, weighed heavily on Hg with skin lightening creams having superior quantities of this metal for the other formulations. This multi-variate analysis consolidates the findings from previous studies. The findings of such research works are at the disposition of authorities and policy makers for the formulation of high-quality cosmetic products.
Variables | Cd | Ni | Hg | As |
---|---|---|---|---|
Pb | 0.538 | 0.495 | 0.527 | 0.579 |
Cd | 0.779 | 0.334 | 0.750 | |
Ni | 0.446 | 0.641 | ||
Hg | 0.465 |
Spearman correlation matrix for the five metals.
Observations plot for the formulations. Legend: Lp = lipsticks; Es = eye shadows; Ep = eyepencils; Ma = mascaras; Mf = foundation; Fp = face paint; Fc = face cream; Tp = toothpaste; SLc = skin-lightening creams; Sb = sunblock; Hp = hair products; Hd = hair dyes; Bl = body lotion; Cl = cleansers; Lo = lotions; and Tc = tonic creams.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
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\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\\n\\nPeer Review Policies
\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
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\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
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The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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Thus, communities that are at risk of oil disasters must anticipate the consequences and prepare for them.",book:{id:"4606",slug:"emerging-pollutants-in-the-environment-current-and-further-implications",title:"Emerging Pollutants in the Environment",fullTitle:"Emerging Pollutants in the Environment - Current and Further Implications"},signatures:"Ismail M.K. Saadoun",authors:[{id:"173457",title:"Prof.",name:"Ismail",middleName:null,surname:"Saadoun",slug:"ismail-saadoun",fullName:"Ismail Saadoun"}]},{id:"49635",doi:"10.5772/61771",title:"Rotifers as Models in Toxicity Screening of Chemicals and Environmental Samples",slug:"rotifers-as-models-in-toxicity-screening-of-chemicals-and-environmental-samples",totalDownloads:2656,totalCrossrefCites:5,totalDimensionsCites:18,abstract:"An important objective of aquatic ecotoxicology is to determine the effects of toxic compounds in organisms that play a central role in aquatic communities where rotifers have a large impact on several important ecological processes. The contribution of the rotifers to secondary production in many aquatic communities is substantial as they are often the larger fraction of zooplankton biomass at certain times of the year. In addition to the importance of their ecological roles in aquatic communities, the rotifers are attractive organisms for ecotoxicological studies by its short life cycles and rapid reproduction, their small size, and little volumes needed for culture and toxicity assays. The main end points used in ecotoxicological studies are mortality, reproduction, behavior, and biomarkers. Such parameters are included in international regulations from all over the world, where different species are used to evaluate the effect of environmental samples or chemical compounds. The high diversity of rotifers is an important issue because it can modify their relative susceptibility to toxicants. Thus, more studies are needed to know the relations and mechanisms involved in clonal variation, sensitivity, and development, which can be all assessed by state-of-the-art procedures.",book:{id:"5101",slug:"invertebrates-experimental-models-in-toxicity-screening",title:"Invertebrates",fullTitle:"Invertebrates - Experimental Models in Toxicity Screening"},signatures:"Roberto Rico-Martínez, Mario Alberto Arzate-Cárdenas, Daniel\nRobles-Vargas, Ignacio Alejandro Pérez-Legaspi, Alvarado-Flores\nJesús and Gustavo Emilio Santos-Medrano",authors:[{id:"96153",title:"Dr.",name:"Roberto",middleName:null,surname:"Rico-Martinez",slug:"roberto-rico-martinez",fullName:"Roberto Rico-Martinez"},{id:"177852",title:"Dr.",name:"Mario Alberto",middleName:null,surname:"Arzate-Cárdenas",slug:"mario-alberto-arzate-cardenas",fullName:"Mario Alberto Arzate-Cárdenas"},{id:"177853",title:"Dr.",name:"Daniel",middleName:null,surname:"Robles-Vargas",slug:"daniel-robles-vargas",fullName:"Daniel Robles-Vargas"},{id:"177854",title:"Dr.",name:"Ignacio Alejandro",middleName:null,surname:"Pérez-Legaspi",slug:"ignacio-alejandro-perez-legaspi",fullName:"Ignacio Alejandro Pérez-Legaspi"},{id:"177855",title:"Dr.",name:"Jesús",middleName:null,surname:"Alvarado-Flores",slug:"jesus-alvarado-flores",fullName:"Jesús Alvarado-Flores"},{id:"177856",title:"Dr.",name:"Gustavo Emilio",middleName:null,surname:"Santos-Medrano",slug:"gustavo-emilio-santos-medrano",fullName:"Gustavo Emilio Santos-Medrano"}]},{id:"49050",doi:"10.5772/60216",title:"Immunotoxicological Threats of Pollutants in Aquatic Invertebrates",slug:"immunotoxicological-threats-of-pollutants-in-aquatic-invertebrates",totalDownloads:1838,totalCrossrefCites:2,totalDimensionsCites:16,abstract:"Immunology deals with the physiological activity of organisms to defend against pathogen and toxin invasion. Invertebrates residing in aquatic ecosystems often face toxicological threat arises from habitat pollution. The aquatic habitat of invertebrates is in the precarious risk of pollution caused by diverse groups of environmental toxins. Immunotoxins have been considered as a special group of pollutants capable of affecting the immunological profile of organisms. Invertebrates residing in water bear ecological, economical, medicinal, industrial, nutritional and biotechnological significance. Global aquatic bioresource is largely composed of invertebrates belonging to multiple Phyla. These organisms, including insects, snails, clams, mussels, crabs and sponges, are physiologically dependent on innate immunological response for defense against pathogen and environmental contaminants. External physicochemical barriers of invertebrates act as primary line of defen against toxin entry. Principal barriers have been identified as shell, tunic, test, carapace, mucus, etc., in diverse species. Toxin-induced morphological damage of specialized immunocytes of invertebrates has been reported. Toxin-induced shift in density, surface adhesion efficacy and aggregation of blood cells or haemocytes have been identified as major xenobiotic stress in invertebrates. Various environmental toxins are capable of initiating alteration in the innate phagocytic response and cytotoxicity of blood cells. Lysosomes of invertebrate haemocytes are functionally involved in intracellular destruction of environmental pathogens. Toxins like arsenic, pyrethroid pesticides, azadirachtin and washing soda were reported to increase the relative fragility of lysosomal membranes of immunocytes. This often leads to impairment in the efficacy of invertebrates to destroy pathogen under the exposure of pollutants. Xenobiotics like pyrethroid pesticides have been recorded to affect apoptosis and necrosis of invertebrate immunocytes. Selected toxin-induced morphological damages of heart, gill, digestive gland, mantle and antennae may result in the overall impairment in homeostatic levels of invertebrates inhabiting the polluted environment. Global environment, in recent times, is under the serious threat of contamination by diverse chemical compounds of unknown or less known toxicity. A thorough ecotoxicological analysis at cellular and molecular levels needs to be carried out in invertebrates occupying the different realms of the planet in future.",book:{id:"4606",slug:"emerging-pollutants-in-the-environment-current-and-further-implications",title:"Emerging Pollutants in the Environment",fullTitle:"Emerging Pollutants in the Environment - Current and Further Implications"},signatures:"Sajal Ray, Soumalya Mukherjee, Niladri Sekhar Bhunia, Anindya\nSundar Bhunia and Mitali Ray",authors:[{id:"173697",title:"Prof.",name:"Sajal",middleName:null,surname:"Ray",slug:"sajal-ray",fullName:"Sajal Ray"},{id:"175476",title:"Dr.",name:"Soumalya",middleName:null,surname:"Mukherjee",slug:"soumalya-mukherjee",fullName:"Soumalya Mukherjee"},{id:"175477",title:"Mr.",name:"Niladri Sekhar",middleName:null,surname:"Bhunia",slug:"niladri-sekhar-bhunia",fullName:"Niladri Sekhar Bhunia"},{id:"175478",title:"Mr.",name:"Anindya Sundar",middleName:null,surname:"Bhunia",slug:"anindya-sundar-bhunia",fullName:"Anindya Sundar Bhunia"},{id:"175479",title:"Dr.",name:"Mitali",middleName:null,surname:"Ray",slug:"mitali-ray",fullName:"Mitali Ray"}]},{id:"49867",doi:"10.5772/62228",title:"Overview of the Standard Methods for Soil Ecotoxicology Testing",slug:"overview-of-the-standard-methods-for-soil-ecotoxicology-testing",totalDownloads:2645,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"This chapter briefly describes the importance of the services provided by soil invertebrates in terrestrial ecosystems and highlights the role of soil fauna in the risk assessments of potentially polluting substances for the terrestrial environment, considering the sensitivity of these organisms, when compared to other indicators of soil quality (e.g., chemical and physical). The main invertebrate groups used in laboratorial ecotoxicological assays are presented and, based on its physiological characteristics and habit requirements, the advantages and disadvantages of using certain taxonomic groups in laboratory assessments are also discussed. The most frequently used methods to perform this type of toxicity tests are summarized, highlighting the fundamental steps of the assays with the species Eisenia fetida/Eisenia andrei, Folsomia candida, Enchytraeus albidus/Enchytraeus crypticus, and Hypoaspis aculeifer, as well as the possible adjustments that are being carried out in tropical countries. Finally, the future prospects, related to the challenge of increasing the realism of laboratory ecotoxicological analyses, are discussed to show the main needs of this study at global and regional perspectives.",book:{id:"5101",slug:"invertebrates-experimental-models-in-toxicity-screening",title:"Invertebrates",fullTitle:"Invertebrates - Experimental Models in Toxicity Screening"},signatures:"Paulo Roger Lopes Alves and Elke Jurandy Bran Nogueira Cardoso",authors:[{id:"176887",title:"Dr.",name:"Paulo Roger",middleName:null,surname:"Lopes Alves",slug:"paulo-roger-lopes-alves",fullName:"Paulo Roger Lopes Alves"},{id:"177015",title:"Prof.",name:"Elke Jurandy",middleName:null,surname:"Bran Nogueira Cardoso",slug:"elke-jurandy-bran-nogueira-cardoso",fullName:"Elke Jurandy Bran Nogueira Cardoso"}]},{id:"48714",doi:"10.5772/60887",title:"The Relevance of ATR-FTIR Spectroscopy in Semiconductor Photocatalysis",slug:"the-relevance-of-atr-ftir-spectroscopy-in-semiconductor-photocatalysis",totalDownloads:3026,totalCrossrefCites:3,totalDimensionsCites:12,abstract:"Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy has a high potential for investigating a wide range of samples and systems. In photocatalysis, various interfacial phenomena can be studied using this technique, including pH-dependent adsorption and photodegradation of probe molecules. The analysis of the processes occurring at the interface of thin particle films deposited on the surface of an ATR crystal, either in the liquid or the gas phase, is perhaps the best way to elucidate the mechanism of adsorption and heterogeneous photocatalytic reactions. This chapter summarizes the recent advances and applications of ATR-FTIR techniques in semiconductor photocatalysis. A brief outlook at some of the possible investigations in this area is provided and the different proposed adsorption and photocatalytic degradation mechanisms are discussed.",book:{id:"4606",slug:"emerging-pollutants-in-the-environment-current-and-further-implications",title:"Emerging Pollutants in the Environment",fullTitle:"Emerging Pollutants in the Environment - Current and Further Implications"},signatures:"Mohamed Faycal Atitar, Hamza Belhadj, Ralf Dillert and Detlef W.\nBahnemann",authors:[{id:"100553",title:"Prof.",name:"Detlef",middleName:null,surname:"Bahnemann",slug:"detlef-bahnemann",fullName:"Detlef Bahnemann"},{id:"173632",title:"M.Sc.",name:"Mohamed Faycal",middleName:null,surname:"Atitar",slug:"mohamed-faycal-atitar",fullName:"Mohamed Faycal Atitar"},{id:"173812",title:"Dr.",name:"Ralf",middleName:null,surname:"Dillert",slug:"ralf-dillert",fullName:"Ralf Dillert"},{id:"175502",title:"MSc.",name:"Hamza",middleName:null,surname:"Belhadj",slug:"hamza-belhadj",fullName:"Hamza Belhadj"}]}],mostDownloadedChaptersLast30Days:[{id:"48714",title:"The Relevance of ATR-FTIR Spectroscopy in Semiconductor Photocatalysis",slug:"the-relevance-of-atr-ftir-spectroscopy-in-semiconductor-photocatalysis",totalDownloads:3030,totalCrossrefCites:3,totalDimensionsCites:12,abstract:"Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy has a high potential for investigating a wide range of samples and systems. In photocatalysis, various interfacial phenomena can be studied using this technique, including pH-dependent adsorption and photodegradation of probe molecules. The analysis of the processes occurring at the interface of thin particle films deposited on the surface of an ATR crystal, either in the liquid or the gas phase, is perhaps the best way to elucidate the mechanism of adsorption and heterogeneous photocatalytic reactions. This chapter summarizes the recent advances and applications of ATR-FTIR techniques in semiconductor photocatalysis. A brief outlook at some of the possible investigations in this area is provided and the different proposed adsorption and photocatalytic degradation mechanisms are discussed.",book:{id:"4606",slug:"emerging-pollutants-in-the-environment-current-and-further-implications",title:"Emerging Pollutants in the Environment",fullTitle:"Emerging Pollutants in the Environment - Current and Further Implications"},signatures:"Mohamed Faycal Atitar, Hamza Belhadj, Ralf Dillert and Detlef W.\nBahnemann",authors:[{id:"100553",title:"Prof.",name:"Detlef",middleName:null,surname:"Bahnemann",slug:"detlef-bahnemann",fullName:"Detlef Bahnemann"},{id:"173632",title:"M.Sc.",name:"Mohamed Faycal",middleName:null,surname:"Atitar",slug:"mohamed-faycal-atitar",fullName:"Mohamed Faycal Atitar"},{id:"173812",title:"Dr.",name:"Ralf",middleName:null,surname:"Dillert",slug:"ralf-dillert",fullName:"Ralf Dillert"},{id:"175502",title:"MSc.",name:"Hamza",middleName:null,surname:"Belhadj",slug:"hamza-belhadj",fullName:"Hamza Belhadj"}]},{id:"49472",title:"Nanotoxicity in Aquatic Invertebrates",slug:"nanotoxicity-in-aquatic-invertebrates",totalDownloads:2175,totalCrossrefCites:3,totalDimensionsCites:11,abstract:"Due to their unique properties, nanomaterials (NMs) are being incorporated in several applications including consumer products, electronics, pesticides and the pharmaceutical industry. As such, the rapid development and large-scale production of NMs has inspired concerns regarding their environmental health risks. In order to address these concerns, there has been a rapid development in the methods of toxicity testing of NMs, specifically in aquatic organisms. Understanding the unique properties of nanoscale materials has proven to be a particular important aspect of their toxicity. Properties such as surface area, surface coating, surface charge, particle reactivity, aggregation and dissolution may affect cellular uptake, in vivo reactivity and distribution across tissues. The behaviour of NPs is influenced by both the inherent properties of the NP as well as environmental properties (such as temperature, pH, ionic strength, salinity, organic matter). As such, this chapter describes methodologies of NM characterization in exposure media and NM in vivo toxicity experimental procedures under variable environmental conditions (with special emphasis on temperature).",book:{id:"5101",slug:"invertebrates-experimental-models-in-toxicity-screening",title:"Invertebrates",fullTitle:"Invertebrates - Experimental Models in Toxicity Screening"},signatures:"Chavon Walters, Edmund Pool and Vernon Somerset",authors:[{id:"6648",title:"Associate Prof.",name:"Vernon",middleName:null,surname:"Somerset",slug:"vernon-somerset",fullName:"Vernon Somerset"},{id:"176939",title:"Dr.",name:"Chavon",middleName:null,surname:"Walters",slug:"chavon-walters",fullName:"Chavon Walters"},{id:"177116",title:"Prof.",name:"Edmund",middleName:null,surname:"Pool",slug:"edmund-pool",fullName:"Edmund Pool"}]},{id:"49635",title:"Rotifers as Models in Toxicity Screening of Chemicals and Environmental Samples",slug:"rotifers-as-models-in-toxicity-screening-of-chemicals-and-environmental-samples",totalDownloads:2659,totalCrossrefCites:6,totalDimensionsCites:19,abstract:"An important objective of aquatic ecotoxicology is to determine the effects of toxic compounds in organisms that play a central role in aquatic communities where rotifers have a large impact on several important ecological processes. The contribution of the rotifers to secondary production in many aquatic communities is substantial as they are often the larger fraction of zooplankton biomass at certain times of the year. In addition to the importance of their ecological roles in aquatic communities, the rotifers are attractive organisms for ecotoxicological studies by its short life cycles and rapid reproduction, their small size, and little volumes needed for culture and toxicity assays. The main end points used in ecotoxicological studies are mortality, reproduction, behavior, and biomarkers. Such parameters are included in international regulations from all over the world, where different species are used to evaluate the effect of environmental samples or chemical compounds. The high diversity of rotifers is an important issue because it can modify their relative susceptibility to toxicants. Thus, more studies are needed to know the relations and mechanisms involved in clonal variation, sensitivity, and development, which can be all assessed by state-of-the-art procedures.",book:{id:"5101",slug:"invertebrates-experimental-models-in-toxicity-screening",title:"Invertebrates",fullTitle:"Invertebrates - Experimental Models in Toxicity Screening"},signatures:"Roberto Rico-Martínez, Mario Alberto Arzate-Cárdenas, Daniel\nRobles-Vargas, Ignacio Alejandro Pérez-Legaspi, Alvarado-Flores\nJesús and Gustavo Emilio Santos-Medrano",authors:[{id:"96153",title:"Dr.",name:"Roberto",middleName:null,surname:"Rico-Martinez",slug:"roberto-rico-martinez",fullName:"Roberto Rico-Martinez"},{id:"177852",title:"Dr.",name:"Mario Alberto",middleName:null,surname:"Arzate-Cárdenas",slug:"mario-alberto-arzate-cardenas",fullName:"Mario Alberto Arzate-Cárdenas"},{id:"177853",title:"Dr.",name:"Daniel",middleName:null,surname:"Robles-Vargas",slug:"daniel-robles-vargas",fullName:"Daniel Robles-Vargas"},{id:"177854",title:"Dr.",name:"Ignacio Alejandro",middleName:null,surname:"Pérez-Legaspi",slug:"ignacio-alejandro-perez-legaspi",fullName:"Ignacio Alejandro Pérez-Legaspi"},{id:"177855",title:"Dr.",name:"Jesús",middleName:null,surname:"Alvarado-Flores",slug:"jesus-alvarado-flores",fullName:"Jesús Alvarado-Flores"},{id:"177856",title:"Dr.",name:"Gustavo Emilio",middleName:null,surname:"Santos-Medrano",slug:"gustavo-emilio-santos-medrano",fullName:"Gustavo Emilio Santos-Medrano"}]},{id:"48738",title:"Impact of Oil Spills on Marine Life",slug:"impact-of-oil-spills-on-marine-life",totalDownloads:4814,totalCrossrefCites:14,totalDimensionsCites:31,abstract:"Petroleum contamination is a growing environmental concern that harms both terrestrial and aquatic ecosystems. However, the public and regulatory and scientific communities have given more attention to the contamination of marine habitats. This is because marine oil spills can have a serious economic impact on coastal activities, as well as on those who exploit the resources of the sea. Thus, communities that are at risk of oil disasters must anticipate the consequences and prepare for them.",book:{id:"4606",slug:"emerging-pollutants-in-the-environment-current-and-further-implications",title:"Emerging Pollutants in the Environment",fullTitle:"Emerging Pollutants in the Environment - Current and Further Implications"},signatures:"Ismail M.K. Saadoun",authors:[{id:"173457",title:"Prof.",name:"Ismail",middleName:null,surname:"Saadoun",slug:"ismail-saadoun",fullName:"Ismail Saadoun"}]},{id:"49867",title:"Overview of the Standard Methods for Soil Ecotoxicology Testing",slug:"overview-of-the-standard-methods-for-soil-ecotoxicology-testing",totalDownloads:2648,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"This chapter briefly describes the importance of the services provided by soil invertebrates in terrestrial ecosystems and highlights the role of soil fauna in the risk assessments of potentially polluting substances for the terrestrial environment, considering the sensitivity of these organisms, when compared to other indicators of soil quality (e.g., chemical and physical). The main invertebrate groups used in laboratorial ecotoxicological assays are presented and, based on its physiological characteristics and habit requirements, the advantages and disadvantages of using certain taxonomic groups in laboratory assessments are also discussed. The most frequently used methods to perform this type of toxicity tests are summarized, highlighting the fundamental steps of the assays with the species Eisenia fetida/Eisenia andrei, Folsomia candida, Enchytraeus albidus/Enchytraeus crypticus, and Hypoaspis aculeifer, as well as the possible adjustments that are being carried out in tropical countries. Finally, the future prospects, related to the challenge of increasing the realism of laboratory ecotoxicological analyses, are discussed to show the main needs of this study at global and regional perspectives.",book:{id:"5101",slug:"invertebrates-experimental-models-in-toxicity-screening",title:"Invertebrates",fullTitle:"Invertebrates - Experimental Models in Toxicity Screening"},signatures:"Paulo Roger Lopes Alves and Elke Jurandy Bran Nogueira Cardoso",authors:[{id:"176887",title:"Dr.",name:"Paulo Roger",middleName:null,surname:"Lopes Alves",slug:"paulo-roger-lopes-alves",fullName:"Paulo Roger Lopes Alves"},{id:"177015",title:"Prof.",name:"Elke Jurandy",middleName:null,surname:"Bran Nogueira Cardoso",slug:"elke-jurandy-bran-nogueira-cardoso",fullName:"Elke Jurandy Bran Nogueira Cardoso"}]}],onlineFirstChaptersFilter:{topicId:"846",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:301,paginationItems:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. 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