In this chapter, the Monte Carlo (MC) core is presented, particularly its cross-sectional libraries and random generators. The main idea is to introduce validation and reliability of MC applications and to explore its limitations. As an example, a comparison between two MC toolkits, namely XRMC (version 6.5.0–2) and Geant4 (version 10.02.p02), and a validation between each of them and experimental data applied to mammography (external dosimetry) are presented. The simulated quantities compared are exposure, kerma, half-value layer, and backscattering. Limitations, advantages, and disadvantages of using a general and specific MC toolkit are commented too.