\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"9025",leadTitle:null,fullTitle:"Parasitology and Microbiology Research",title:"Parasitology and Microbiology Research",subtitle:null,reviewType:"peer-reviewed",abstract:"The study of both unicellular and multicellular living beings and the diseases they produce from a biological point of view requires constant review of their relationship with their host and environment, given their indisputable sanitary importance. In this sense, in parasitology and microbiology, updated and concise information on life cycle, taxonomic classification, clinical manifestations, diagnosis, treatment, epidemiological behavior, and control measures is of vital importance. This is what we pursue with this book. The approach to parasitology and microbiology and the research that is carried out on it is unquestionable because the associations between life forms have been present from the very beginning of life.Research in parasitology and microbiology is necessary and indispensable for controlling diseases that affect much of the world with serious economic and social consequences. The challenge is to promote research to keep these diseases at bay. This book shows what has been done up to now and what can be done in the future to combat infectious diseases.",isbn:"978-1-78985-902-7",printIsbn:"978-1-78985-901-0",pdfIsbn:"978-1-83880-737-5",doi:"10.5772/intechopen.82990",price:139,priceEur:155,priceUsd:179,slug:"parasitology-and-microbiology-research",numberOfPages:374,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"d9a211396d44f07d2748e147786a2c8b",bookSignature:"Gilberto Antonio Bastidas Pacheco and Asghar Ali Kamboh",publishedDate:"June 17th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/9025.jpg",numberOfDownloads:14651,numberOfWosCitations:12,numberOfCrossrefCitations:16,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:36,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:64,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 15th 2019",dateEndSecondStepPublish:"September 20th 2019",dateEndThirdStepPublish:"November 19th 2019",dateEndFourthStepPublish:"February 7th 2020",dateEndFifthStepPublish:"April 7th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"238219",title:"Dr.",name:"Gilberto Antonio",middleName:null,surname:"Bastidas Pacheco",slug:"gilberto-antonio-bastidas-pacheco",fullName:"Gilberto Antonio Bastidas Pacheco",profilePictureURL:"https://mts.intechopen.com/storage/users/238219/images/system/238219.jpeg",biography:"Prof. Gilberto Antonio Bastidas Pacheco is a physician with degrees in Pre-hospital Emergency Care, Executive Direction for Senior Management in Health, and Occupational Health and Safety. Along with a Health Management Course equivalent to the Public Health Middle Course, Magister Scientiae in Education Management and also in Protozoology, Prof. Bastidas holds a Ph.D. in Parasitology. He is a full professor at the Faculty of Health Sciences, Department of Public Health, University of Carabobo, Valencia, Venezuela. He has authored several articles published in national and international journal, and is also an arbitrator of scientific articles, member of the editorial committees of several journals, and a textbook writer and lecturer.",institutionString:"University of Carabobo",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Carabobo",institutionURL:null,country:{name:"Venezuela"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"225390",title:"Dr.",name:"Asghar Ali",middleName:null,surname:"Kamboh",slug:"asghar-ali-kamboh",fullName:"Asghar Ali Kamboh",profilePictureURL:"https://mts.intechopen.com/storage/users/225390/images/system/225390.jpeg",biography:"Dr. Asghar Ali Kamboh was born in Mehrabpur, Sindh, Pakistan. He completed his studies in Veterinary Medicine and Masters in Veterinary Microbiology in 2003 and 2007 respectively, with distinguished grades. In 2009, he was awarded an overseas scholarship by the Government of Pakistan and proceeded to China for doctoral studies. Currently, he is working as an Associate Professor in the Department of Veterinary Microbiology, Sindh Agriculture University, Tandojam. He has edited two books and published more than 100 research and review articles in national and international peer-reviewed journals. He has supervised/co-supervised more than 35 M.Phil students. He is also the author of many books and book chapters. In addition, he is an editor/editorial board member of many scholarly journals in the area of animal health and production.",institutionString:"Sindh Agriculture University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Sindh Agriculture University",institutionURL:null,country:{name:"Pakistan"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"909",title:"Parasitology",slug:"parasitology"}],chapters:[{id:"63799",title:"Role of the Cytoskeletal Actomyosin Complex in the Motility of Cyanobacteria and Fungal Spores",doi:"10.5772/intechopen.81299",slug:"role-of-the-cytoskeletal-actomyosin-complex-in-the-motility-of-cyanobacteria-and-fungal-spores",totalDownloads:830,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"This study demonstrates the involvement of the cytoskeleton in the movement of cyanobacteria and fungal spores to their hosts to establish a state of symbiosis or pathogenicity. The term symbiosis sensu lato is referred not only to commensalism and mutualism but also to the parasitic aberrations. The establishment of association implies that the endohabitant can move on a wet surface until finding an entry point in the exohabitant surface. In aqueous media, the exohabitant secretes glycoproteins that form a chemoattraction gradient for the invading cells. In lichens, the gradient consists of fungal lectins whose function is to recognize a compatible green alga or cyanobacterium. In the case of pathogens, the secreted proteins usually are a mixture that includes false quorum and chemoattractant signals, and cell wall digestive enzymes. The results indicate that fungal lectins and defense proteins bind to specific cell wall receptors for signaling the activation of cytoskeleton, causing successive cycles of cell contraction-relaxation that permits the migration of the endohabitant. In this study, different biochemical and microscopy techniques have been used. The mechanisms through which the cytoskeleton carries out these cycles of cell contractionrelaxation are described, being this a remarkable advance compared to previous results.",signatures:"Elena Sánchez-Elordi, Eva María Díaz, Carlos Vicente and María Estrella Legaz",downloadPdfUrl:"/chapter/pdf-download/63799",previewPdfUrl:"/chapter/pdf-preview/63799",authors:[{id:"68681",title:"Prof.",name:"Carlos",surname:"Vicente",slug:"carlos-vicente",fullName:"Carlos Vicente"},{id:"261033",title:"Prof.",name:"María-Estrella",surname:"Legaz",slug:"maria-estrella-legaz",fullName:"María-Estrella Legaz"},{id:"261034",title:"Dr.",name:"Elena",surname:"Sánchez-Elordi",slug:"elena-sanchez-elordi",fullName:"Elena Sánchez-Elordi"},{id:"261035",title:"Dr.",name:"Eva",surname:"Díaz",slug:"eva-diaz",fullName:"Eva Díaz"}],corrections:null},{id:"71205",title:"Hemorheological Evaluation and Cytokine Production in Dogs Naturally Infected with Anaplasmataceae",doi:"10.5772/intechopen.91191",slug:"hemorheological-evaluation-and-cytokine-production-in-dogs-naturally-infected-with-anaplasmataceae",totalDownloads:686,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In this chapter, we describe that naturally infected dogs with Anaplasmataceae show altered rhreological parameters. Also, we have showed that lower viscosity correlated with the lower erythrocyte number and release of IFN-γ. The rheometry of the fresh blood samples was measured by using the Modular Compact Rheometer—MCR 102 (Anton Paar® GmbH, Ostfildern, Germany), and the graphs were obtained using Rheoplus software. Blood count data were obtained by analysis in a private laboratory. Diagnostic confirmation was obtained by molecular PCR technique that was used to determine the groups of not infected and infected by Anaplasmataceae. Serum cytokines were dosed by flow cytometry (FACScalibur BD®) using BD® Biosciences Cytometric Bead Array (CBA) Human Th1/Th2/Th17 Cytokine kits. The results showed a correlation between blood viscosity (p < 0.05, r = 0.73) and shear rate (p < 0.05; r = −0.676) with IFN-γ in the group of infected dogs that presented anemia, as well as correlations of shear rate with erythrocytes (p < 0.05; r = −0.88). Thus, IFN-γ appears to play an important role in the immunomodulation of the rheological behavior of naturally infected dogs to Anaplasmataceae. The alterations in cytokines profile and their relationship with blood viscosity and hematological parameters was related in this study the first time of dogs naturally infected with Anaplasmataceae.",signatures:"Saulo Pereira Cardoso, Giane Regina Paludo, José Nivaldo da Silva, Adenilda Honório-França and Eduardo Luzia França",downloadPdfUrl:"/chapter/pdf-download/71205",previewPdfUrl:"/chapter/pdf-preview/71205",authors:[{id:"66955",title:"Prof.",name:"Adenilda",surname:"Honorio-Franca",slug:"adenilda-honorio-franca",fullName:"Adenilda Honorio-Franca"}],corrections:null},{id:"68779",title:"Malarial Inflammation-Driven Pathophysiology and Its Attenuation by Triterpene Phytotherapeutics",doi:"10.5772/intechopen.88731",slug:"malarial-inflammation-driven-pathophysiology-and-its-attenuation-by-triterpene-phytotherapeutics",totalDownloads:992,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Malaria driven pathophysiology inimically conjoined to systemic inflammation response cascade in a vicious feed-forward cycle destined to a terrible debilitation or demise of the host. The Plasmodium parasite initiates physiological changes when it is transmitted into the human host by intermediate host and vector. Sporozoites injection elicits immunological and inflammatory response suppression facilitating movement into the blood stream undetected, destined to hepatocyte. Subsequently, hepatocyte invasion culminates in intracellular growth and conversion of the parasites rapturing hepatocytes releasing merozoites into the extrahepatic circulation. Inflammatory and immunological response initiation results in overt malarial disease symptoms. Initially, inflammatory response alleviates and curtails infection. Activation of leukocytes, lymphocytes, monocytes, and phagocytes secretes inflammatory mediators, chemokines, cytokines cytoadhering molecules which accelerate infection patency. Hormonal processes influence disease tolerance without necessarily interfering with parasitemia. Current treatment is anti-parasitic. Phytotherapeutic intervention in malaria is anti-parasitic and anti-disease effects that terminate the vicious cycle and alleviating disease. The phytochemicals, in malarial experimental and clinical work, include asiatic acid, maslinic acid, oleanolic acid, and inflammatory and immunological aberrations evolving in malaria and the effects of phytochemical therapeutics in the alleviation of the disease to enable leverage of future treatment regimens through harnessing existing plants materials is explored.",signatures:"Greanious Alfred Mavondo, Blessing Nkazimulo Mkhwanazi, Mayibongwe Louis Mzingwane, Rachael Dangarembizi, Blessing Zambuko, Obadiah Moyo, Patience Musiwaro, Francis Farai Chikuse, Colline Rakabopa, Tariroyashe Mpofu and Joy Mavondo",downloadPdfUrl:"/chapter/pdf-download/68779",previewPdfUrl:"/chapter/pdf-preview/68779",authors:[{id:"202805",title:"Prof.",name:"Alfred Mavondo-Nyajena Mukuwa",surname:"Greanious",slug:"alfred-mavondo-nyajena-mukuwa-greanious",fullName:"Alfred Mavondo-Nyajena Mukuwa Greanious"},{id:"241675",title:"Dr.",name:"Mayibongwe",surname:"Mzingwane",slug:"mayibongwe-mzingwane",fullName:"Mayibongwe Mzingwane"},{id:"263433",title:"Dr.",name:"Obadiah",surname:"Moyo",slug:"obadiah-moyo",fullName:"Obadiah Moyo"},{id:"303469",title:"Dr.",name:"Blessing Nkazimulo",surname:"Mkhwanazi",slug:"blessing-nkazimulo-mkhwanazi",fullName:"Blessing Nkazimulo Mkhwanazi"},{id:"304350",title:"Mrs.",name:"Joy",surname:"Mavondo",slug:"joy-mavondo",fullName:"Joy Mavondo"},{id:"304869",title:"Dr.",name:"Francis Farai",surname:"Chikuse",slug:"francis-farai-chikuse",fullName:"Francis Farai Chikuse"},{id:"305018",title:"Dr.",name:"Blessing",surname:"Zambuko",slug:"blessing-zambuko",fullName:"Blessing Zambuko"},{id:"305019",title:"Dr.",name:"Rachael",surname:"Dangarembizi",slug:"rachael-dangarembizi",fullName:"Rachael Dangarembizi"},{id:"305309",title:"Ms.",name:"Tariroyashe",surname:"Mpofu",slug:"tariroyashe-mpofu",fullName:"Tariroyashe Mpofu"},{id:"305580",title:"Dr.",name:"Greanious Alfred",surname:"Mavondo",slug:"greanious-alfred-mavondo",fullName:"Greanious Alfred Mavondo"},{id:"308997",title:"M.Sc.",name:"Colleen",surname:"Rakabopa",slug:"colleen-rakabopa",fullName:"Colleen Rakabopa"}],corrections:null},{id:"68751",title:"Clinical and Immuno-Pathology Aspects of Canine Demodicosis",doi:"10.5772/intechopen.88763",slug:"clinical-and-immuno-pathology-aspects-of-canine-demodicosis",totalDownloads:1059,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Canine demodicosis is a common and often severe dermatopathy of dogs. It is caused mainly by Demodex canis, a parasitic mite of the skin of dogs of the genus Demodex, of the order Acarina and family Demodecidae. This study is aimed to review the clinical-pathological presentation of canine demodicosis and the cytokine-mediated immune response to the cutaneous density of the mite. Only dogs with a defective immune response will present the disease, whether localised or generalised. Microscopically, the dermal inflammatory response is similar among dogs. Localised and generalised demodicosis and pyoderma associated with a high cutaneous density of mites are factors associated with aggravation of lesions in both forms of disease presentation. In addition, the participation of cytokines has been investigated in the induction of the immune response in the different forms of the disease. Although different research groups have invested in studies aimed at elucidating the canine demodicosis pathogenesis, there is still insufficient data to understand the important role of the host immune system in triggering clinical signs and the reproductive management is still an effective preventive method for disease perpetuation.",signatures:"Valéria Régia F. Sousa, Naiani D. Gasparetto and Arleana B.P.F. Almeida",downloadPdfUrl:"/chapter/pdf-download/68751",previewPdfUrl:"/chapter/pdf-preview/68751",authors:[{id:"305312",title:"Prof.",name:"Valeria Regia",surname:"Sousa",slug:"valeria-regia-sousa",fullName:"Valeria Regia Sousa"},{id:"305313",title:"Prof.",name:"Arleana",surname:"Almeida",slug:"arleana-almeida",fullName:"Arleana Almeida"},{id:"305317",title:"Dr.",name:"Naiani",surname:"Gasparetto",slug:"naiani-gasparetto",fullName:"Naiani Gasparetto"}],corrections:null},{id:"69165",title:"Protein-Protein Interactions in Malaria: Emerging Arena for Future Chemotherapeutics",doi:"10.5772/intechopen.89217",slug:"protein-protein-interactions-in-malaria-emerging-arena-for-future-chemotherapeutics",totalDownloads:768,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Malaria is one of the most deadly diseases infecting humans. Advances in elimination and vector control have reduced the global malaria burden in the past decade; however, the emerging threat of drug resistance and suboptimal vaccine efficacies threaten global eradication efforts. Unlocking novel drug and vaccine targets while simultaneously mitigating spread of resistant strains seems to be the need of the hour. Protein-protein interactions (PPIs), an integral part of host-pathogen cross-talk and parasite survival, have only recently emerged as promising drug targets. Large PPI networks (interactome) are being developed to better our understanding of various parasite biochemical pathways. In this chapter, we throw light on several newly characterized protein-protein interactions between the host (humans) and parasite (plasmodium) in key processes such as hemoglobin degradation, enzyme regulation, protein export, egress, invasion, and drug resistance and further discuss their viability for development as novel chemotherapeutic targets.",signatures:"Rahul Pasupureddy, Sriram Seshadri, Rajnikant Dixit and Kailash C. Pandey",downloadPdfUrl:"/chapter/pdf-download/69165",previewPdfUrl:"/chapter/pdf-preview/69165",authors:[{id:"90701",title:"Dr.",name:"Sriram",surname:"Seshadri",slug:"sriram-seshadri",fullName:"Sriram Seshadri"},{id:"303178",title:"Dr.",name:"Kailash",surname:"Pandey",slug:"kailash-pandey",fullName:"Kailash Pandey"},{id:"304022",title:"Mr.",name:"Rahul",surname:"Pasupureddy",slug:"rahul-pasupureddy",fullName:"Rahul Pasupureddy"},{id:"310111",title:"Dr.",name:"Rajnikant",surname:"Dixit",slug:"rajnikant-dixit",fullName:"Rajnikant Dixit"}],corrections:null},{id:"70551",title:"Relationship of Parasitic Index and Cytokine Profile in Canine Visceral Leishmaniasis",doi:"10.5772/intechopen.90573",slug:"relationship-of-parasitic-index-and-cytokine-profile-in-canine-visceral-leishmaniasis",totalDownloads:625,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Visceral leishmaniasis (VL) is a zoonotic parasitic disease caused by Leishmania infantum (L. chagasi) that infects cells of the monocyte-phagocyte system. This work aims to describe the bone marrow parasitism in dogs naturally infected by L. chagasi, and to correlate with serum concentrations of cytokines and antibody level. It evaluated 42 dogs, 21 uninfected and 21 infected by L. infantum, of both sexes and of different ages; dogs were classified into three clinical stages: stage I, mild disease; stage II, moderate disease; and stage III, severe disease. Parasitic index was determined by real-time polymerase chain reaction (PCR) and cytokine serum concentration by flow cytometry. The average parasitic index of infected dogs was 4.59 × 1010 copies/μl. IL-4 and TNF-α concentrations were higher in infected dogs than in the control group. Antibody levels were positively correlated with IL-4 expression. There was a significant positive correlation of IL-6 cytokine levels with the evolution of stages I and III. Antibody levels were positively correlated with IL-4 expression. There was a significant positive correlation of IL-6 cytokine levels with the evolution of stages I and III. However, this cytokine can be used as a marker to distinguish between different clinical stages.",signatures:"José Nivaldo da Silva, Valéria Régia Franco Sousa, Arleana do Bom Parto Ferreira de Almeida, Adenilda Cristina Honorio-França and Eduardo Luzía França",downloadPdfUrl:"/chapter/pdf-download/70551",previewPdfUrl:"/chapter/pdf-preview/70551",authors:[{id:"305312",title:"Prof.",name:"Valeria Regia",surname:"Sousa",slug:"valeria-regia-sousa",fullName:"Valeria Regia Sousa"},{id:"305313",title:"Prof.",name:"Arleana",surname:"Almeida",slug:"arleana-almeida",fullName:"Arleana Almeida"},{id:"105780",title:"Prof.",name:"Eduardo",surname:"França",slug:"eduardo-franca",fullName:"Eduardo França"},{id:"315522",title:"Dr.",name:"Jose Nivaldo",surname:"Da Silva",slug:"jose-nivaldo-da-silva",fullName:"Jose Nivaldo Da Silva"},{id:"315523",title:"Prof.",name:"Adenilda Cristina",surname:"Honorio-França",slug:"adenilda-cristina-honorio-franca",fullName:"Adenilda Cristina Honorio-França"}],corrections:null},{id:"67800",title:"Toxoplasma Immunomodulation Related to Neuropsychiatric Diseases",doi:"10.5772/intechopen.86695",slug:"-em-toxoplasma-em-immunomodulation-related-to-neuropsychiatric-diseases",totalDownloads:775,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Toxoplasma gondii (T. gondii) causes toxoplasmic encephalitis resulting from reactivation of latent toxoplasmosis. It is the most frequent clinical manifestation, characterized by multiple necrotizing brain lesions. Bradyzoite tissue cysts activate an immune response that has a major impact on controlling parasite persistence in the brain. The immune mechanisms stimulated in the brain cause a local inflammatory mediated by Th1 immune reaction cytokines. Several studies have linked this process to that active during different neuropsychiatric disorders, such as Schizophrenia. In addition to the immune reaction activated in the brain, this latter has the capacity to stimulate neurotransmitter production. T. gondii induces high concentrations of dopamine and tyrosine hydroxylase in the central nervous system and has also been shown to increase kynurenine/tryptophan ratio and elevated Kynurenic acid level, mainly in astrocyte cells. This imbalance plays a role in the pathophysiology of Schizophrenia. Results of different studies explain in this chapter support the idea that Toxoplasma is an etiological factor in Schizophrenia.",signatures:"Mammari Nour and Halabi Mohamad Adnan",downloadPdfUrl:"/chapter/pdf-download/67800",previewPdfUrl:"/chapter/pdf-preview/67800",authors:[{id:"297033",title:"Dr.",name:"Nour",surname:"Mammari",slug:"nour-mammari",fullName:"Nour Mammari"},{id:"297039",title:"Dr.",name:"Mohamad Adnan",surname:"Halabi",slug:"mohamad-adnan-halabi",fullName:"Mohamad Adnan Halabi"}],corrections:null},{id:"68651",title:"Sexual Processes in Microbial Eukaryotes",doi:"10.5772/intechopen.88469",slug:"sexual-processes-in-microbial-eukaryotes",totalDownloads:848,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Two principal ideas have been proposed to explain the primary adaptive function of the sexual process of meiosis: (1) meiosis, and particularly meiotic recombination, is a process for repairing DNA and (2) meiosis, by means of meiotic recombination, is a process for generating beneficial genetic variation among progeny. We review the sexual processes of a number of well-studied microbial eukaryotes: Saccharomyces cerevisiae, Saccharomyces paradoxus, Schizosaccharomyces pombe, Candida albicans, Ustilago maydis, Paramecium tetraurelia, Volvox carteri, Trypanosoma brucei, Neurospora crassa, and Amoebozoa. We indicate aspects of the sexual processes of these microbial eukaryotes, where they have been established, that support the idea that meiosis is primarily a process for repairing DNA. In addition, we review the likely origin of meiotic sex among the microbial eukaryotes. A prokaryotic archaeon is the likely ancestor of eukaryotes. Extant archaea are capable of a sexual process involving syngamy and recombinational repair of genome damage, suggesting that the precursor of eukaryotic meiotic sex may already have been present in the archaeal ancestor of eukaryotes. We believe that attainment of an understanding of the adaptive function of meiotic sex in microbial eukaryotes is of considerable importance since it will likely apply to meiotic sex in eukaryotes generally.",signatures:"Harris Bernstein and Carol Bernstein",downloadPdfUrl:"/chapter/pdf-download/68651",previewPdfUrl:"/chapter/pdf-preview/68651",authors:[{id:"61946",title:"Dr.",name:"Carol",surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein"},{id:"162255",title:"Dr.",name:"Harris",surname:"Bernstein",slug:"harris-bernstein",fullName:"Harris Bernstein"}],corrections:null},{id:"70655",title:"An Insight into the Changing Scenario of Gut Microbiome during Type 2 Diabetes",doi:"10.5772/intechopen.90697",slug:"an-insight-into-the-changing-scenario-of-gut-microbiome-during-type-2-diabetes",totalDownloads:734,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The gut microbiome consists of bacteria, protozoans, viruses, and archaea collectively called as gut microbiota. Gut microbiome (GM) modulates a variety of physiological responses ranging from immune and inflammatory responses, neuronal signalling, gut barrier integrity and mobility, synthesis of vitamins, steroid hormones, neurotransmitters to metabolism of branched-chain aromatic amino acids, bile salts, and drugs. Type 2 diabetes mellitus (T2D) is a highly prevalent metabolic disorder that is featured by imbalance in blood glucose level, altered lipid profile, and their deleterious consequences. GM dysbiosis a major factor behind the incidence and progression of insulin resistance and is responsible for altering of intestinal barrier functions, host metabolic, and signaling pathways. The GM of type 2 diabetes (T2DM) patients is characterized by reduced levels of Firmicutes and Clostridia and an increased ratio of Bacteroidetes:Firmicutes. Endotoxemia stimulates a low-grade inflammatory response, which is known to trigger T2DM. Xenobiotics including dietary components, antibiotics, and nonsteroidal anti-inflammatory drugs strongly affect the gut microbial composition and can promote dysbiosis. However, the exact mechanisms behind the dynamics of gut microbes and their impact on host metabolism are yet to be deciphered. Interventions that can restore equilibrium in the GM have beneficial effects and can improve glycemic control.",signatures:"Alpana Mukhuty, Chandrani Fouzder, Snehasis Das and Dipanjan Chattopadhyay",downloadPdfUrl:"/chapter/pdf-download/70655",previewPdfUrl:"/chapter/pdf-preview/70655",authors:[{id:"278297",title:"MSc.",name:"Alpana",surname:"Mukhuty",slug:"alpana-mukhuty",fullName:"Alpana Mukhuty"},{id:"286872",title:"Ms.",name:"Chandrani",surname:"Fouzder",slug:"chandrani-fouzder",fullName:"Chandrani Fouzder"},{id:"311848",title:"Mr.",name:"Snehasis",surname:"Das",slug:"snehasis-das",fullName:"Snehasis Das"},{id:"311849",title:"Mr.",name:"Dipanjan",surname:"Chattopadhyay",slug:"dipanjan-chattopadhyay",fullName:"Dipanjan Chattopadhyay"}],corrections:null},{id:"69898",title:"Gut Microbiome: A New Organ System in Body",doi:"10.5772/intechopen.89634",slug:"gut-microbiome-a-new-organ-system-in-body",totalDownloads:1114,totalCrossrefCites:8,totalDimensionsCites:15,hasAltmetrics:1,abstract:"The gut microbiome is comprised of various types of bacteria, fungi, protozoa, and viruses naturally occurring in humans and animals as normal microflora. Gut microorganisms are typically host specific, and their number and type vary according to different host species and environment. Gut microbes contribute directly and/or indirectly to various physiological processes including immune modulation, regulation of various neurotransmitter, and hormones, as well as production of many antioxidants and metabolites. They also play a role as antibiotic, anti-inflammatory, anti-diabetic, and anti-carcinogenic agents. Moreover, the ability of gut microbes to attenuate various systemic diseases like coronary heart disease, irritable bowel syndrome, metabolic diseases like diabetes mellitus, and infectious diseases like diarrhea has recently been reported. Current research findings have enough evidence to suggest that gut microbiome is a new organ system mainly due to the microorganisms’ specific biochemical interaction with their hosts and their systemic integration into the host biology. Investigations into the potential ability of gut microbiome to influence metabolism inside their host via biochemical interaction with antibiotics and other drugs has recently been initiated. This chapter specifically focuses on the importance of gut microorganisms as a new organ system.",signatures:"Haseeb Anwar, Shahzad Irfan, Ghulam Hussain, Muhammad Naeem Faisal, Humaira Muzaffar, Imtiaz Mustafa, Imran Mukhtar, Saima Malik and Muhammad Irfan Ullah",downloadPdfUrl:"/chapter/pdf-download/69898",previewPdfUrl:"/chapter/pdf-preview/69898",authors:[{id:"240684",title:"Dr.",name:"Haseeb",surname:"Anwar",slug:"haseeb-anwar",fullName:"Haseeb Anwar"},{id:"244522",title:"Dr.",name:"Ghulam",surname:"Hussain",slug:"ghulam-hussain",fullName:"Ghulam Hussain"},{id:"244524",title:"Mr.",name:"Imtiaz",surname:"Mustafa",slug:"imtiaz-mustafa",fullName:"Imtiaz Mustafa"},{id:"310200",title:"Dr.",name:"Shahzad",surname:"Irfan",slug:"shahzad-irfan",fullName:"Shahzad Irfan"},{id:"310201",title:"Dr.",name:"Humaira",surname:"Muzaffar",slug:"humaira-muzaffar",fullName:"Humaira Muzaffar"},{id:"310202",title:"Dr.",name:"Imran",surname:"Mukhtar",slug:"imran-mukhtar",fullName:"Imran Mukhtar"},{id:"310203",title:"Ms.",name:"Saima",surname:"Malik",slug:"saima-malik",fullName:"Saima Malik"},{id:"310204",title:"Dr.",name:"Muhammad",surname:"Irfan Ullah",slug:"muhammad-irfan-ullah",fullName:"Muhammad Irfan Ullah"},{id:"311357",title:"Dr.",name:"Muhammad Naeem",surname:"Faisal",slug:"muhammad-naeem-faisal",fullName:"Muhammad Naeem Faisal"}],corrections:null},{id:"65643",title:"Microscale Mechanics of Plug-and-Play In Vitro Cytoskeleton Networks",doi:"10.5772/intechopen.84401",slug:"microscale-mechanics-of-plug-and-play-in-vitro-cytoskeleton-networks",totalDownloads:816,totalCrossrefCites:1,totalDimensionsCites:6,hasAltmetrics:0,abstract:"This chapter describes recent techniques that have been developed to reconstitute and characterize well-controlled, tunable networks of actin and microtubules outside of cells. It describes optical tweezers microrheology techniques to characterize the linear and nonlinear mechanics of these plug-and-play in vitro networks from the molecular-level to mesoscopic scales. It also details fluorescence microscopy and single-molecule tracking methods to determine macromolecular transport properties and stress propagation through cytoskeleton networks. Throughout the chapter the intriguing results that this body of work has revealed are highlighted—including how the macromolecular constituents of cytoskeleton networks map to their signature responses to stress or strain; and the elegant couplings between network structure, macromolecular mobility, and stress response that cytoskeleton networks exhibit.",signatures:"Shea N. Ricketts, Bekele Gurmessa and Rae M. Robertson-Anderson",downloadPdfUrl:"/chapter/pdf-download/65643",previewPdfUrl:"/chapter/pdf-preview/65643",authors:[{id:"271445",title:"Prof.",name:"Rae",surname:"Robertson-Anderson",slug:"rae-robertson-anderson",fullName:"Rae Robertson-Anderson"},{id:"289983",title:"Ms.",name:"Shea",surname:"Ricketts",slug:"shea-ricketts",fullName:"Shea Ricketts"},{id:"289984",title:"Dr.",name:"Bekele",surname:"Gurmessa",slug:"bekele-gurmessa",fullName:"Bekele Gurmessa"}],corrections:null},{id:"68693",title:"The Mitosis of Entamoeba histolytica Trophozoites",doi:"10.5772/intechopen.88734",slug:"the-mitosis-of-em-entamoeba-histolytica-em-trophozoites",totalDownloads:830,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The mechanisms of mitosis in higher eukaryotic organisms are very well studied; however, regarding protozoa, there are still many questions in need of an answer. Because of the complexity with which it carries out this process, many forms of mitosis exist, such as open orthomitosis, semi-open orthomitosis, semi-open pleuromitosis, closed intranuclear pleuromitosis, closed intranuclear orthomitosis, and closed extranuclear pleuromitosis. The fascinating aspect about the mitosis of Entamoeba histolytica trophozoites is that it falls out of the context of this classification, but not entirely. The Entamoeba histolytica trophozoites first carry out karyokinesis and then cytokinesis. The mitosis of this parasite is comprised of the following phases: prophase, metaphase, early and late anaphase, early and late telophase, and karyokinesis. The difference lies in the mechanism by which it carries out the distribution of the genetic material because it forms three mitotic spindles: two radial spindles that practically surround every group of chromosomes and one that we call inter microtubule-organizing centers (IMTOCs). The latter transports each group of chromosomes at each of the nucleus poles. Based on these observations, we propose that Entamoeba histolytica trophozoites carry out a type of mitosis we have called modified intranuclear pleuromitosis open.",signatures:"Eduardo Gómez-Conde, Miguel Ángel Vargas Mejía, María Alicia Díaz y Orea, Luis David Gómez-Cortes and Tayde Guerrero-González",downloadPdfUrl:"/chapter/pdf-download/68693",previewPdfUrl:"/chapter/pdf-preview/68693",authors:[{id:"147294",title:"Dr.",name:"María Alicia",surname:"Díaz-Orea",slug:"maria-alicia-diaz-orea",fullName:"María Alicia Díaz-Orea"},{id:"309230",title:"Ph.D.",name:"Eduardo",surname:"Gómez-Conde",slug:"eduardo-gomez-conde",fullName:"Eduardo Gómez-Conde"},{id:"309231",title:"Dr.",name:"Miguel Ángel",surname:"Vargas Mejía",slug:"miguel-angel-vargas-mejia",fullName:"Miguel Ángel Vargas Mejía"},{id:"309233",title:"Dr.",name:"Tayde",surname:"Guerrero Gonzalez",slug:"tayde-guerrero-gonzalez",fullName:"Tayde Guerrero Gonzalez"},{id:"309236",title:"BSc.",name:"Luis David",surname:"Gómez-Cortes",slug:"luis-david-gomez-cortes",fullName:"Luis David Gómez-Cortes"}],corrections:null},{id:"70407",title:"Challenges for the Control of Poultry Red Mite (Dermanyssus gallinae)",doi:"10.5772/intechopen.90439",slug:"challenges-for-the-control-of-poultry-red-mite-em-dermanyssus-gallinae-em-",totalDownloads:796,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The Poultry Red Mite, Dermanyssus gallinae, is an ectoparasite which is considered the major pest for the egg-laying industry. The mite hides in crevices and cracks during daylight and feed on the blood of the hens in the darkness. It can also parasitize other bird and mammal species, including man that can develop gamasoidosis when bitten at work or private residences. The control of the mite infestations has relied in synthetic acaricides, but the development of resistances and the restricted list of authorized products make fundamental the development of novel control measure. The combination of alternative control measures, such as monitoring of the mite infestation, plant-derived products, inner dusts, biological control and vaccines, poses as the best way for achieving satisfactory results.",signatures:"José Francisco Lima-Barbero, Margarita Villar, Ursula Höfle and José de la Fuente",downloadPdfUrl:"/chapter/pdf-download/70407",previewPdfUrl:"/chapter/pdf-preview/70407",authors:[{id:"59778",title:"Prof.",name:"José",surname:"De La Fuente",slug:"jose-de-la-fuente",fullName:"José De La Fuente"},{id:"82738",title:"Dr.",name:"Margarita",surname:"Villar",slug:"margarita-villar",fullName:"Margarita Villar"},{id:"312004",title:"Ph.D. Student",name:"José Francisco",surname:"Lima Barbero",slug:"jose-francisco-lima-barbero",fullName:"José Francisco Lima Barbero"},{id:"314846",title:"Dr.",name:"Ursula",surname:"Höfle",slug:"ursula-hofle",fullName:"Ursula Höfle"}],corrections:null},{id:"69242",title:"Bronchopulmonary Lophomoniasis, Infection by Endocommensal Protozoa of Intradomiciliary Cockroaches: Presentation of a Case in an Immunocompromised Patient from Querétaro, Mexico",doi:"10.5772/intechopen.89219",slug:"bronchopulmonary-lophomoniasis-infection-by-endocommensal-protozoa-of-intradomiciliary-cockroaches-p",totalDownloads:704,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Infection in humans by the intestinal protozoan of cockroaches and termites called Lophomonas blattarum has been diagnosed in respiratory infections of children aged 2–5 years contaminated orally or by air, with cysts or trophozoites contained in the feces of the cockroach Periplaneta americana. In respiratory infections of adults, it is difficult to diagnose since the cyst or trophozoite is not recognized as a human pathogen and is only related to immunosuppressed patients, transplant patients with severe lung disease and those living in poor and unhealthy sanitary conditions. Normally, its presence is manifested with fevers of 38–39°C, cough with thick expectoration, respiratory insufficiency and pulmonary abscesses. The laboratory diagnosis is mainly based on bronchoscopic cytologies and bronchoalveolar lavage biopsies. The case in question is about a 60-year-old male. Single, he lives alone, with a diagnosis of 9 baths behind non-Hodgkin lymphoma, undergoing treatment with radiotherapy and chemotherapy. For edema after treatment, thoracentesis and pericardiocentesis were performed, as well as gastrostomy, which he maintained for 1 year. He started with throat discomfort, followed by production of productive cough without blood, general weakness, and difficulty breathing, with apparent diagnosis of possible respiratory failure due to mycobacteria. It was possible to visualize the protozoan, in fresh preparations of bronchial aspirate and expectoration in wet assembly with saline solution and stained with Pap smears, Harris Hematoxylin and Eosin (H/E), and Giemsa.",signatures:"Maria Elena Villagrán-Herrera, Ricardo Francisco Mercado-Curiel, José Trinidad López-Vázquez, Maria del Carmen Aburto-Fernández, Nicolás Camacho-Calderón, Javier Ávila-Morales and José Antonio De Diego-Cabrera",downloadPdfUrl:"/chapter/pdf-download/69242",previewPdfUrl:"/chapter/pdf-preview/69242",authors:[{id:"210676",title:"Dr.",name:"Maria Elena",surname:"Villagrán Herrera",slug:"maria-elena-villagran-herrera",fullName:"Maria Elena Villagrán Herrera"}],corrections:null},{id:"71977",title:"House Dust Mites: Ecology, Biology, Prevalence, Epidemiology and Elimination",doi:"10.5772/intechopen.91891",slug:"house-dust-mites-ecology-biology-prevalence-epidemiology-and-elimination",totalDownloads:834,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:1,abstract:"House dust mites burrow cheerfully into our clothing, pillowcases, carpets, mats and furniture, and feed on human dead skin cells by breaking them into small particles for ingestion. Dust mites are most common in asthma allergens, and some people have a simple dust allergy, but others have an additional condition called atopic dermatitis, often stated to as eczema by reacting to mites with hideous itching and redness. The most common type of dust mites are Dermatophagoides farinae Hughes (American house dust mite) and Dermatophagoides pteronyssinus Trouessart (European house dust mite) of family Pyroglyphidae (Acari), which have been associated with dermatological and respiratory allergies in humans such as eczema and asthma. A typical house dust mite measures 0.2–0.3 mm and the body of mite has a striated cuticle. A mated female house dust mite can live up to 70 days and lays 60–100 eggs in the last 5 weeks of life, and an average life cycle is 65–100 days. In a 10-week life span, dust mite produces about 2000 fecal particles and an even larger number of partially digested enzyme-covered dust particles. They feed on skin flakes from animals, including humans and on some mold. Notably, mite’s gut contains potent digestive enzymes peptidase 1 that persist in their feces and are major inducers of allergic reactions, but its exoskeleton can also contribute this. Allergy testing by a physician can determine respiratory or dermatological symptoms to undergo allergen immunotherapy, by exposing to dust mite extracts for “training” immune system not to overreact. The epidemiologic data on the occurrence of house dust mites convincingly associates with an increased indoor air humidity by increased occurrence of mites. The most effective way to prevent or minimize exposure to dust mites in our homes is thorough cleaning, use of high-efficiency particulate air filters and pest management. There are a number of things that can be done to get rid of dust mites, for instance, using a dehumidifier and washing bedding in hot water. Additionally, it is a noble practice to encase bedding, mattress and pillows in impermeable covers that prevent dust mites from taking up residence in beds. Owing to their everywhere presence, diversity, and wide distribution, mite species can be used as valid and reliable pieces of evidence for resolving of forensic cases.",signatures:"Muhammad Sarwar",downloadPdfUrl:"/chapter/pdf-download/71977",previewPdfUrl:"/chapter/pdf-preview/71977",authors:[{id:"272992",title:"Dr.",name:"Muhammad",surname:"Sarwar",slug:"muhammad-sarwar",fullName:"Muhammad Sarwar"}],corrections:null},{id:"70698",title:"Leishmaniasis",doi:"10.5772/intechopen.90680",slug:"leishmaniasis",totalDownloads:729,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Leishmaniasis is a vector-borne tropical/subtropical disease caused by an intracellular parasite transmitted to humans by sand fly bite. It is endemic in Asia, Africa, the Americas, and the Mediterranean region. Worldwide reports include 1.5–2 million new cases each year, more than 300 million at risk of acquiring the disease, and 70,000 deaths per year. Clinical features depend on the Leishmania species and immune response of the host, varying from localized cutaneous disease to visceral form with potentially fatal outcome; however, the common presentation is either cutaneous, mucocutaneous, or visceral leishmaniasis. Many therapeutic agents are being used in Leishmania treatment, but the only effective treatment is achieved with current pentavalent antimonials. WHO considers Leishmaniasis as one of the “Neglected Tropical Diseases” that continues to be prevalent despite international, national, and local efforts towards its control and elimination over the last decade. This chapter reviews the global perspective of Leishmaniasis with increasing recognition of emerging “Atypical forms” and new surge of disease across the world mainly due to increasing conflicts in endemic areas leading to forced migration among other causes. All these challenges related to environment, disease, and vector pose major implications on WHO’s leishmaniasis control and elimination plan.",signatures:"Salwa S. Sheikh, Amaar A. Amir, Baraa A. Amir and Abdulrazack A. Amir",downloadPdfUrl:"/chapter/pdf-download/70698",previewPdfUrl:"/chapter/pdf-preview/70698",authors:[{id:"309118",title:"Dr.",name:"Salwa",surname:"Sheikh",slug:"salwa-sheikh",fullName:"Salwa Sheikh"},{id:"309119",title:"Mr.",name:"Amaar",surname:"Amir",slug:"amaar-amir",fullName:"Amaar Amir"},{id:"309120",title:"Mr.",name:"Baraa",surname:"Amir",slug:"baraa-amir",fullName:"Baraa Amir"},{id:"310569",title:"Dr.",name:"Abdulrazack",surname:"Amir",slug:"abdulrazack-amir",fullName:"Abdulrazack Amir"}],corrections:null},{id:"72005",title:"A New Outlook in Lymphatic Filariasis Elimination in India",doi:"10.5772/intechopen.92454",slug:"a-new-outlook-in-lymphatic-filariasis-elimination-in-india",totalDownloads:743,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In India, human lymphatic filariasis (LF) is the most common vector-borne disease after malaria. It is a roundworm nematode parasitic helminthiases group of diseases under Filarioidea type of infection. The parasites are found in the lymphatic system, damage the system leading to deformities of body organs. Of the eight human filarial parasites, Wuchereria bancrofti, Brugia malayi and B. timori are involved with the lymphatic system. Globally W. bancrofti is the most predominant species sharing 90% of the burden. In India, W. bancrofti and B. malayi are present. The revised control strategy was aimed at a single-dose mass drug administration (MDA) and home-based morbidity management. The Elimination of LF (ELF) was initiated in 2004 in 202 districts which were expanded later in 256 districts after a pilot study in LF endemic districts initiated in 1997. The initial start of ELF campaign was with a single drug, i.e. diethylcarbamazine (DEC), but later in 2007, a combination of two drugs DEC and albendazole (ALB) were given through MDA. Now a third drug ivermectin (IVM) has been added to accelerate the elimination process by 2020 which is the global goal of elimination under Global Programme to Eliminate Lymphatic Filariasis (GPELF).",signatures:"Susanta Kumar Ghosh and Pradeep Kumar Srivastava",downloadPdfUrl:"/chapter/pdf-download/72005",previewPdfUrl:"/chapter/pdf-preview/72005",authors:[{id:"301164",title:"Prof.",name:"Susanta",surname:"Ghosh",slug:"susanta-ghosh",fullName:"Susanta Ghosh"},{id:"320470",title:"Dr.",name:"Pradeep",surname:"Srivastava",slug:"pradeep-srivastava",fullName:"Pradeep Srivastava"}],corrections:null},{id:"68463",title:"State of the Art and Future Directions of Cryptosporidium spp.",doi:"10.5772/intechopen.88387",slug:"state-of-the-art-and-future-directions-of-em-cryptosporidium-em-spp-",totalDownloads:769,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Cryptosporidium species are protozoan parasites that infect epithelium surfaces in gastrointestinal and respiratory tracts of humans and a range of animals worldwide. Cryptosporidiosis has been associated with considerable morbidity and, under certain circumstances, mortality. Humans can acquire it by consuming food and drink containing oocysts, which have been recognised as a major cause for diarrhoeal disease. The ubiquitousness of the infective oocyst, its resilience to environmental pressures, and the low dose of oocyst exposure needed for infection amplify to outbreaks of Cryptosporidium traced to drinking and recreational water. Unlike in developing countries where lack of sustained access to safe water creates tremendous burdens of Cryptosporidium diarrhoea, this scenario is aggravated due to limited diagnosis and therapeutics. However, over the past few decades, growing information on Cryptosporidium genomes have allowed novel insight into the host-parasite relationship. Future field research on potential tools will focus on biology-derived parasite products applicable to drugs and diagnosis. This chapter reviews available data on biology, transmission, life cycle, diagnosis, genome, and a few but important progresses in the field of cryptosporidiosis.",signatures:"Helena Lúcia Carneiro Santos, Karina Mastropasqua Rebello and Teresa Cristina Bergamo Bomfim",downloadPdfUrl:"/chapter/pdf-download/68463",previewPdfUrl:"/chapter/pdf-preview/68463",authors:[{id:"300603",title:"Dr.",name:"Helena",surname:"Santos",slug:"helena-santos",fullName:"Helena Santos"},{id:"309101",title:"Dr.",name:"Karina",surname:"Mastropasqua Rebello",slug:"karina-mastropasqua-rebello",fullName:"Karina Mastropasqua Rebello"},{id:"309102",title:"Prof.",name:"Teresa Cristina",surname:"Bergamo Bomfim",slug:"teresa-cristina-bergamo-bomfim",fullName:"Teresa Cristina Bergamo Bomfim"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6979",title:"Parasites and Parasitic Diseases",subtitle:null,isOpenForSubmission:!1,hash:"f55304c8bd1d92268e33689c368f9e33",slug:"parasites-and-parasitic-diseases",bookSignature:"Gilberto Bastidas",coverURL:"https://cdn.intechopen.com/books/images_new/6979.jpg",editedByType:"Edited by",editors:[{id:"238219",title:"Dr.",name:"Gilberto Antonio",surname:"Bastidas Pacheco",slug:"gilberto-antonio-bastidas-pacheco",fullName:"Gilberto Antonio Bastidas Pacheco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1692",title:"Parasitology",subtitle:null,isOpenForSubmission:!1,hash:"b2110e81c765897e4ffdfbd340495e25",slug:"parasitology",bookSignature:"Mohammad Manjur Shah",coverURL:"https://cdn.intechopen.com/books/images_new/1692.jpg",editedByType:"Edited by",editors:[{id:"94128",title:"Dr.",name:"Mohammad Manjur",surname:"Shah",slug:"mohammad-manjur-shah",fullName:"Mohammad Manjur Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5527",title:"Natural Remedies in the Fight Against Parasites",subtitle:null,isOpenForSubmission:!1,hash:"d705be119e74a50305952521b2b5ece0",slug:"natural-remedies-in-the-fight-against-parasites",bookSignature:"Hanem Khater, M. 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\r\n\tParaplegia means a complete lack of ambulation caused by dysfunction of the spinal cord and/or cauda equina. Signs and symptoms of paraplegia depend on the involvement of the cord or cauda equina. Paraplegia caused by thoracic or lumbosacral cord involvement is labeled as myelopathy. Signs and symptoms of myelopathy include spasticity, brisk DTR, pathologic reflexes such as Babinski, clonus, dyssynergic sphincter, and sometimes pain and dysesthesia. Lesions of cauda equina cause flaccid paraplegia, atrophy, hyporeflexia, and overflow bowel and bladder incontinency. Several different mechanisms are involved in producing paraplegia. Direct trauma to the spinal cord, spinal column disorders, degenerative disc disease, discogenic process, malignancy, infectious process, inflammatory process, and radiation are among common causes of paraplegia. Diagnosis of paraplegia is based on clinical, imaging, neurophysiologic, and sometimes lab studies. According to the type of paraplegia, there are many surgical, medical and rehabilitation approaches. Spasticity, bedsore, UTI, heterotopic ossification, DVT, and deconditioning are among common complications of paraplegia. Regular assessment and appropriate management are crucial in the proper treatment and prevention of complications in paraplegia.
",isbn:"978-1-83969-780-7",printIsbn:"978-1-83969-779-1",pdfIsbn:"978-1-83969-781-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"a6528402917e26f82aa364193b88b0f0",bookSignature:"Dr. Seyed Mansoor Rayegani",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11835.jpg",keywords:"Lower Limbs Weakness, Inability to Walk, Incontinency, Myelopathy, Thoracic Myelopathy, Lumbosacral Myelopathy, Cauda Equina Syndrome, Spinal Stenosis, Bowel and Bladder Dysfunction, Sphincter Control, Paraparesis, Discopathy",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 28th 2022",dateEndSecondStepPublish:"May 26th 2022",dateEndThirdStepPublish:"July 25th 2022",dateEndFourthStepPublish:"October 13th 2022",dateEndFifthStepPublish:"December 12th 2022",remainingDaysToSecondStep:"9 days",secondStepPassed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Professor and President of Physical Medicine and Rehabilitation research center at Shahid Beheshti University of medical sciences, President of Iranian society of PM&R, and Chairperson of Iranian board of PM&R. Professor Rayegani published more than 130 medical articles.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"79728",title:"Dr.",name:"Seyed Mansoor",middleName:null,surname:"Rayegani",slug:"seyed-mansoor-rayegani",fullName:"Seyed Mansoor Rayegani",profilePictureURL:"https://mts.intechopen.com/storage/users/79728/images/system/79728.jfif",biography:"Professor S. Mansoor Rayegani is an academic physiatrist who completed his residency training in Physical Medicine & Rehabilitation (PM&R) at Shiraz University of Medical Sciences, Iran, in 1992. In 1994, he began his academic career as Assistant Professor of PM&R at Shohada Medical Center, Shahid Beheshti University of Medical Sciences, just after passing the Iranian Board of PM&R in which he gained the first rank. He is one of the founding members of a PM&R residency program in Tehran. Professor Rayegani’s fields of interest include electrodiagnostic medicine, pain, spinal cord injury, neurorehabilitation, and medical education. He supervises and coordinates a neurorehabilitation and hypertonicity clinic. He has supervised more than forty postgraduate residency theses and published about 130 indexed medical articles. He is also an editorial board member for the Journal of the International Society of Physical and Rehabilitation Medicine (JISPRM) and a member of the journal’s education and publication committee. Professor Rayegani is currently president of the Iranian society of PM&R, editor in chief of Physical Medicine, Rehabilitation, and Electrodiagnosis (PMRE), director of the Iranian Board of PM&R, and chief of the PM&R Research Center at Shahid Beheshti University of Medical Sciences.",institutionString:"Shahid Beheshti University of Medical Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466998",firstName:"Dragan",lastName:"Miljak",middleName:"Anton",title:"Dr.",imageUrl:"https://mts.intechopen.com/storage/users/466998/images/21564_n.jpg",email:"dragan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully"}},relatedBooks:[{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. 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The health benefits of green tea, derived from the leaves of the
Among the health benefits that have been studied using green tea are: as an antioxidant, anti-inflammatory, anticarcinogenic, in cardiovascular health, oral health, and as an antimicrobial. Antioxidant effects come from the ability of green tea to limit the amount of free radicals by binding to reactive oxygen species (ROS) [3, 4]:
Green tea is an excellent source of powerful antioxidants, so it makes sense that it could reduce your risk of cancer, which it appears to do;
Which Improves Dental Health and Lowers Your Risk of Infection [13]
The catechins in green tea also have other biological effects.
Some studies show that they can kill bacteria and inhibit viruses like the influenza virus, potentially lowering your risk of infections.
\n
Studies show that the catechins in green tea can inhibit the growth of
The medically important components of green tea are the polyphenols, most importantly the flavonoids. The main flavonoids in tea are the catechins, making up 30–40% of the water-soluble solids in green tea [3, 11]. The different types of tea vary in the amount of catechins that they contain, with green tea containing the most, then Oolong tea, then black tea. The initial steaming process in the production of green tea destroys the enzyme polyphenol oxidase, thus protecting the polyphenol content. There are four main catechins in tea: (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epigallocatechin-3-gallate (EGCG). In green tea, EGCG is the most abundant, representing approximately 59% of the total catechins. EGC is next, making up approximately 19%, then ECG, at 13.6% and EC, at 6.4% [6, 10].
\nGreen tea contains less caffeine than coffee, but enough to produce an effect. It also contains the amino acid L-theanine, which can work synergistically with caffeine to improve brain function [8].
\nMultiple studies show that the catechin compounds in green tea can have various protective effects on neurons in test tubes and animal models, potentially lowering the risk of Alzheimer’s and Parkinson’s [15].
\nBlack, green and white teas are the most popular beverages worldwide [16].
\nTea leaves are known for its antibacterial activity against any microorganisms. It is one of the most popular beverages worldwide.
\nBlack tea has a long history of use dating back to China approximately 5000 years ago. It is made from the dried leaves of
The chemical components in tea include alkaloids (theobromine, caffeine, theophylline), polyphenols, amino acids, polysaccharides, volatile acids, vitamins, lipids as well as inorganic elements [17, 18, 19]. Black tea is used for treating headaches, low blood pressure, preventing heart disease, including atherosclerosis and heart attack, preventing Parkinson’s disease, reducing the risk of stomach and colon cancer, lung, ovarian and breast cancers [20].
\nCurrently, a growing consumption of tea is observed in western countries, where it has been considered as functional food.
\nNutritional Value of Black Tea Like other types of tea, black tea contains:
Caffeine
Amino acids
Carbohydrates
Proteins
Potassium
Major minerals and trace minerals
Manganese
Fluoride
Polyphenols
Black tea also contains catechins (the powerful antioxidants in tea that fight cancer-causing cells and help prevent heart disease), tannins (the naturally occurring chemical compounds that give black tea and red wine their astringency), guanine (a natural stimulant) and xanthine (another natural stimulant, similar to caffeine).
\nThe many antioxidants and polyphenols in black tea are associated with a number of health benefits. Specifically, black tea contains complex flavonoids, which are polyphenols that aid in disease prevention. A single cup of black tea contains an average of 200 mg of flavonoids. Many doctors now recommend getting 600 mg of flavonoids per day for a range of health benefits. The flavonoid polyphenols in black tea known as thearubigin and theaflavin act as especially powerful antioxidants. Interestingly, these two flavonoids are more concentrated in black tea than in green tea [21].
\nAdditionally, black tea is low in sodium and calories (if you do not add a sweetener). Plus, black tea has a bold flavor, making it a good substitute for those accustomed to soft drinks other unhealthy beverages (which also tend to have bold flavors) [22].
\nThe biological properties of tea include effects on the Central System (CNS) and antioxidant effects, attributed to the presence of methylxanthines, such as caffeine and phenolic compounds, especially catechins [23].
\nBlack tea is more oxidised than all other types of teas. It contains antioxidants and other substances that might help protect the heart and blood vessels. It is also used for treating headache and low blood pressure; preventing heart disease, including “hardening of the arteries” (atherosclerosis) and heart attack [24].
\nThe tannins in black tea do not just give it its characteristic taste. Several studies have shown that tannins help fight viruses such as influenza (“the flu”), dysentery, and hepatitis. Black tea also contains alkylamine antigens, which help boost immune response [25]. Both Iranian non fermented (green tea) and fermented (black tea) have anti
Black and green tea have antibacterial activity against many pathogens.
\nEffectiveness of aqueous extract of green, black and red tea leaves against some types of Gram positive and negative bacteria [19].
\nAn
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\n
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All tea extracts have shown significant antibacterial activity against
Black tea extract also had the ability to completely inhibit
Black tea is recorded to have anticolon cancer, lung, ovarian and breast cancers [21, 25]; green or black tea has polyphenols as prophylactic and therapeutic agents. Theaflavins and catechins seem to act on cancer cells largely through different pathways, so utilisation of both could offer synergistic anticancer effects, but so far no work has been done on the cumulative effects of EGCG and TF on prostate cancer. Therefore, in this study, we have investigated if EGCG in combination with TF can reduce the rate of prostate cancer growth, and we have observed greater cell death compared to application of either TF or EGCG alone.
\nConsumption of black tea, rich in polyphenols, has been found to reduce ovarian cancer risk. Theaflavin (TF1), theaflavin-3-gallate (TF2a), theaflavin-3′-gallate (TF2b) and theaflavin-3, 3′-digallate (TF3) are four main theaflavin derivatives found in black tea.
\nAll four theaflavin derivatives inhibited ovarian cancer cells. Some of the effects and mechanisms of TF1 are different from those of the other three theaflavin derivatives [17, 21].\n
\nDrinking black tea benefits the skin in three ways. First, it nourishes the skin with vitamins B2, C, and E, with minerals such as magnesium, potassium, and zinc, and essential polyphenols and tannins. Second, its caffeine and some of its other chemical components can kill oral viruses, which helps prevent skin infections (and pimples). Third, black tea has been shown to reduce “mimic wrinkles” and signs of premature ageing.
\nBlack tea can also benefit your skin with direct contact/application. For example, placing black tea bags under your eyes helps reduce puffiness and dark circles. And using black tea for herbal baths can provide an antioxidant boost for your skin and may even provide low levels of sun protection [22, 26].
\nThe healthiest tea for you is the one you will want to drink every day. By that definition, if you live in the West, the tea that is the healthiest for you is probably black tea. Over 90% of all tea sold in the West is black tea (or red tea, as it is known in the East).
\nLike green tea, oolong tea and white tea, black tea is made from leaves of the
The major health benefits of black tea include its nutritional value, anti-cancer benefits, digestive benefits, beneficial effects on skin and hair health, and much more. Grab a cup of tea (preferably organic tea) and learn more.
\nBlack tea also contains catechins (the powerful antioxidants in tea that fight cancer-causing cells and help prevent heart disease), tannins (the naturally occurring chemical compounds that give black tea and red wine their astringency), guanine (a natural stimulant) and xanthine (another natural stimulant, similar to caffeine).
\nThe many antioxidants and polyphenols in black tea are associated with a number of health benefits. Specifically, black tea contains complex flavonoids, which are polyphenols that aid in disease prevention. A single cup of black tea contains an average of 200 mg of flavonoids. Many doctors now recommend getting 600 mg of flavonoids per day for a range of health benefits. The flavonoid polyphenols in black tea known as thearubigin and theaflavin act as especially powerful antioxidants. Interestingly, these two flavonoids are more concentrated in black tea than in green tea [22, 23, 27].
\nBlack tea is abundant in antioxidants, such as flavonoids. These antioxidants have been demonstrated to lower the risk of heart disease. They do this by preventing the oxidation of LDL cholesterol and preventing damage in both the bloodstream and at artery walls. Additionally, black tea flavonoids can both improve coronary vasodilation and reduce clots, and its manganese may reduce the risk of coronary heart disease by helping cardiac muscle function. Studies have shown that as few as three cups of tea per day can improve heart health [25].
\nPerhaps the most-studied tea health benefit is its anti-cancer benefit. While most of the study has been on green tea, there is a growing body of evidence that black tea also plays a role in cancer prevention [25].
\nIt appears that the polyphenols in tea help prevent the formation of potential carcinogens in the body. This is particularly true with certain types of cancer, such as ovarian cancer, lung cancer, prostate cancer, colorectal cancer, and bladder cancer. Some studies also show that black tea may help prevent stomach cancer, prostate cancer, breast cancer and oral cancers (especially for those who use tobacco products) [25, 26, 27, 28].
\nThe mechanism with which black tea prevents cancer is an interesting one. Black tea contains a compound called TF-2. This chemical causes apoptosis (“programmed death”) of cancer cells without harming normal, healthy cells. This helps to stop cancer growth before it even becomes noticeable, and may help in cases where cancer has already been diagnosed. Additionally, black tea also prevents cancer by inhibiting the formation and growth of malignant tumors [25].
\nThe tannins in black tea do not just give it its characteristic taste. Several studies have shown that tannins help fight viruses such as influenza (“the flu”), dysentery, and hepatitis. Black tea also contains alkylamine antigens, which help boost immune response [25].
\nThere are many folk tales about tea, freshening the breath and cleansing the mouth. It turns out that they are true. Research has found that black tea may reduce oral cancers. Additionally, tea’s polyphenols and tannin’s kill and prevent the bacteria that cause tooth decay, and to drastically reduce the oral bacteria that cause bad breath [25].
\nThe tannin in tea in general (and black tea in particular—it has more of them than other tea types) offer digestive benefits. They soothe gastric and intestinal illnesses, generally aid in digestion and decrease intestinal activity (making them useful for those with diarrhea) [24, 25].
\nAlthough it may seem rather vain compared to some of the other more life-altering health benefits of black tea, black tea is fantastic for your hair.
\nThe high levels of antioxidants and caffeine in black tea both benefit hair health. The caffeine decreases a hormone that causes hair loss (known as DHT or dihydrotestosterone), while the antioxidants promote healthy hair growth. However, excess caffeine may stunt hair growth, so be careful not to overdo it. Black tea can also add shine, luster, and darkness to your hair if you incorporate it into your hair care regimen [25].
\nIf you drink tea regularly, you are more likely to have stronger bones and connective tissue than someone who does not drink tea regularly. Scientists believe this may be due to tea’s phytochemicals [25].
\nThe caffeine in black tea has been shown to improve mental focus and concentration by promoting blood flow in the brain. Unlike drinks with higher levels of caffeine and other stimulants (i.e., coffee and energy drinks), the caffeine in black tea is less likely to over-stimulate the heart and cause other unpleasant side effects.
\nCaffeine aside, studies show that L-theanine (an amino acid found in black tea) balances the effects of caffeine in a unique way, helping you concentrate more fully on tasks and act in a focused but relaxed manner. Furthermore, studies show that 1 month of four cups of black tea a day reduces levels of the stress hormone cortisol enough to boost your memory function, and some studies suggest that regular black tea consumption may prevent Parkinson’s disease [8].
\nModerate caffeine consumption not only stimulates metabolism, but it also increases alertness and overall brain function. The caffeine in tea is mitigated by the naturally occurring chemical L-theophylline, which makes the effects of tea on energy level more smooth and continuous than the sometimes jarring effects of coffee and caffeinated sodas. Additionally, while caffeine mainly stimulates the muscles, L-theophylline targets the heart, kidneys and respiratory system, so the overall impact on the body is more evenly distributed and balanced [25].
\nOur review shows that tea have great health benefit for human body, the nutritional value of tea components shows great health benefit for heart and vascular system, fight cancer, inhibit pathogens, healthy for skin, hair, bone regulate metabolism and more.
\nMass spectrometry is an analytical technique whose purpose is discovering new molecules, determining quantities of known components and determining structural and chemical properties of a molecule.
The detection capability in mass spectrometry is very small, of about 10−12 grams and its application field is multifaceted, being used in industries such as: chemical, pharmaceutical, biotechnology, food, among others. It is frequently used in environmental and medical sciences, and in molecular biology.
Some of its most common uses are related to:
Performing doping tests in athletes [1].
Locating petroleum reservoirs through the use of precursors in the rocks [2].
Controlling fermentation of products in biotechnology processes [3].
Determining genetic damages [4].
Determining the presence of contaminants in food [5].
Identifying the structure of biomolecules, such as nucleic acids [4].
Analyzing the biodegradation of medications [6].
Establishing the age of geochemical and archeological samples [7].
The origin of mass spectrometry goes back to the experiments by J. J. Thompson, which evidenced, on one side, the presence of electrons, and on the other side, the presence of positive radiation, when energy falls into a vacuum tube to which a difference in electric potential was applied [8]. Thompson remarked the importance that this new technique might have in the field of chemical analysis and described it in his book “Rays of Positive Electricity and Their Application to Chemical Analysis” [9]; however, despite this interesting possibility of use, mass spectrometry was relegated to the field of experiments in physics. It was not until the 1940s, that the first analytical mass spectrometers started to be developed.
At present, Mass Spectrometry and Nuclear Magnetic Resonance, are the most complete and widespread techniques in educational and research labs around the world, regarding the study and discovery of organic molecules. In the field of natural products many of the studies about secondary metabolites have been validated in a mass spectrometer, since it is a very complete technique for the identification and control of this type of substances.
A mass spectrometer is an instrument with the capability of measuring the mass of a molecule after it has been ionized. Due to the extremely small mass of a molecule expressed in grams or kilograms, it is more convenient to measure its molecular mass, expressed as mols; for example, the mass of a hydrogen atom is 1.66 x 10−24 grams, but its mol is approximately 1 gram, or if it is desired in Daltons, considering that this unit is equivalent to 1/12 of the mass of an isotope carbon-12.
The spectrometry does not directly measure the mass of an isotope, but rather its mass-to-charge ratio of the ions that are formed (m/z), where z is the charge, most of the ions formed in the mass spectrometry have a value of charge of z = 1.
The mass spectrometers are constituted by various components, namely: 1) system for introducing the sample, 2) ionization source, 3) mass analyzer, 4) detection system and 5) data analysis system. Components 2, 3 and 4 should be necessarily subject to a vacuum system; a summarized scheme of the instrument may be seen in Figure 1.
Scheme of a mass spectrometer.
The parts that diversify and create the different instrumentation variants are the ionization source and the mass analyzer.
A classic system requires the formation of ions in gaseous phase; however, the latest instrumentation advances have generated methodologies that enable introducing molecules in liquid phase or even in solid phase. The process for generating the mass spectrum is:
Production of ions and fragmentation
Separation of the ions according to their mass-to-charge ratio
Detection
The ion production, also known as ionization, occurs in different manners. The classic one is by means of the interaction of an electric current (electronic ionization) with a substance in vapor phase. The energy is considered as high and has been standardized at 70 eV, which is greater than the energy of the bonds of any molecule.
Another method is chemical ionization (Cl) where the rupture is produced due to the incidence of a gaseous substance with an extra proton, for example CH5+, on substances in vapor phase. Chemical ionization is less energetic than electronic ionization and produces less fragmentation.
Other types of ionization of recent development are:
(Fast Atom Bombardment, FAB): impact of atoms at high velocity on a sample dissolved in a liquid matrix.
(Secondary Ion Mass Spectrometry, SIMS): impact of ions at high velocity on a thin film of sample deposited on a metal substrate, or dissolved in a liquid matrix (Liquid SIMS).
(Plasma Desorption, PD): impact of fragments of nuclear fission, for example, of the 252Cf on a solid sample deposited on a metal foil.
(Matrix Assisted Laser Desorption Ionization, MALDI): impact of high energy photons on a sample enclosed in an organic solid matrix.
(Field Desorption, FD): imposition of a strong electric field on a sample deposited on a special metal probe.
(Electrospray Ionization, ESI): formation of charged liquid particles which are emitted by desorption or desolvation.
The purpose of the mass analyzers is to separate the ions according to their mass-to-charge ratio. The mass analyzers have different features, namely:
Magnetic sector mass spectrometry. They deviate the trajectory of the ions in circular trajectories that depend on the momentum/charge ratio.
Quadrupole. Consists of 4 poles or bars arranged parallelly, the separation of the ions is the result of the application of a combination of continuous (DC) and alternating at a radiofrequency (RF) electric fields.
Ion trap. The ion trap operates similarly to the quadrupole, with the difference that it may hold and store the ions inside the trap.
Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR). The ions are trapped electrostatically in a cubic cell inside a constant magnetic field.
Time off flight (TOF). They separate ions according to the time employed to travel a particular distance; an ion of smaller mass will have a larger velocity, based on equation Ec = mv2/2 that relates kinetic energy with mass and velocity.
Figure 2 shows the ionization sources, as well as the diverse analyzers which will finally determine the types of instruments that are found in the market.
Ionization sources and analyzers in mass spectrometry.
In most mass spectrometry analyzers, with the exception of the FT-ICR, ions are detected after the separation, transforming the collision energy of the ions on the detector, in order to produce in it further emission of electron and photon ions that are opportunely measured in charge or light detectors.
A mass spectrometer of recent development is the orbitrap, which is a modification of the ionic trap; in this the ions are injected tangentially in an electric field, and they remain turning around a central electrode, highlighting a high mass resolution of them [10].
A mass spectrum consists of a diagram of ionic abundance as a function of its mass-to-charge ratio. The mass spectra are reported as simple histograms, such as the one seen in Figure 3.
Mass spectrum of the methanol.
In this example all the ions are positively charged; it is observed the molecular ion at a value m/z of 32, a majority ion at m/z 31 due to the loss of the H from the OH group, and an ion at m/z 15 which is due to the loss of the hydroxyl (OH).
Depending on the ionization source and the energy employed, spectra will be available with more or less positive fragments aside from the information about the molecular weight of the molecule.
High purity solid samples may be directly placed in a probe inside the instrument, in which it occurs the evaporation of the sample that has been introduced in the vacuum system. Gaseous or liquid samples require special systems for feeding the regulated flow.
When the sample to be analyzed is a complex mixture of compounds, chromatography equipment may be coupled to the mass spectrometer, such as gas chromatography (GC) or high-performance liquid chromatography (HPLC). The GC/MS systems were developed in the 60s, because the samples that enter to chromatographic column are already in gaseous phase and this facilitates its introduction in the mass spectrometer; an instrument of this type is observed in Figure 4. The coupling with liquid chromatography did not occur until the 80s, due to difficulty of producing an operational vacuum system.
Gas chromatography equipment coupled to mass spectrometer. Life Sciences Laboratory, Salesian Polytechnic University.
At present, the development of GC/MS and LC/MS systems provide a great variety of instruments that facilitate the separation and analysis work, both for quantifying as well as for discovering new structures, with the field of natural products being one of the most benefited from these latest advances.
The coupling of two MS–MS mass analysis states is useful for analyzing compounds in complex mixtures and for determining the structure of unknown molecules. The MS–MS evaluation offers the possibility of analyzing the ions formed in a further fragmentation of those ions formed in the first test.
If the first ionization technique offers the possibility of having various fragments in a highly purified sample, the second ionization offers the possibility of acquiring valuable structural information, and through it achieve a high possibility of determining the structure of a new molecule.
The high development achieved in the last hundred years by mass spectrometry with a great variability of techniques and instruments, makes possible that basically all molecules that are part of natural products may be analyzed, both qualitatively and quantitatively [11, 12], Figure 5 shows various spectra of natural substances obtained by electronic ionization. The extracts coming from biological matrices with natural products are generally a mixture of various compounds, and thus it is very common the use of GC or LC coupled systems [13, 14].
Spectra of natural molecules obtained by electronic ionization.
New techniques such as Electrospray Ionization, have increased the number of possible biomolecules to be analyzed, including those of high molecular weights [15]. Similarly, the use of powerful mass analyzers makes it possible to analyze molecular ions or fractionated ions with an extremely efficient resolution [16].
Essential oils are metabolites of volatile nature; therefore, studies of chemical composition are relatively simple, generally achieving percentages above 90% when investigating the molecules that compose these natural products [17, 18].
The combination of evaluations of mass spectra and retention indices provide information that may be verified in specific databases for this type of compounds [19]. Further studies of GC/MS in molecules separated in TLC, may reveal specific biological properties such as antibacterial or antioxidant [20].
Various plant species contain saturated and unsaturated fatty acids, studies are generally carried out by GC/MS, although the compounds of high molecular weight are non-volatile, this is solved employing chemical derivatization methodologies, forming methyl or ethyl esters [21, 22]. Numerous species of nutritional and pharmaceutical interest such as
The aromas and flavors in fruits and vegetables are fundamental for distinguishing their taste features, given their volatility the GC/MS equipment is the ideal for understanding the chemistry of this group of substances. Many of these molecules are very volatile and therefore are not removable in vapor stream, for introducing them in the chromatographic system they are previously extracted with non-polar solvents [26] or may be directly injected with head space introduction systems [27, 28].
Few phenolic compounds may be directly analyzed in an GC/MS system, generally those structures of low molecular weight [29].
Most of the phenolic and polyphenolic compounds are non-volatile and have two analytic paths for their structures to be determined, the first is through chemical derivatization, using the mechanism of sylitation, which make them volatile [30, 31].
The second is through instruments that couple HPLC to mass spectrometry, which has made that a large part of the tests are carried out directly, after their separation in one column. The advantage of the electrospray ionization technique is the possibility of ionizing molecules that lack of volatility [32, 33].
The use of mass analyzers of resolution greater than the quadrupole, such as the TOF or the orbitrap, has resulted in values of m/z that reach more precise levels, which has resulted in greater confidence in the identification of a substance [34, 35, 36].
The alkaloids are active ingredients whose structural feature is to have nitrogen in their structure, many of these molecules have a significant biological activity. Some alkaloids may be directly analyzed in GC/MS equipment, such as nicotine and other present in tobacco [37], caffeine and xanthine alkaloids [38, 39], and others whose volatility enables its separation in gas chromatography such as tropane alkaloids [40].
The most frequently used method in the test of these metabolites is the LC/MS in its diverse variants, such as the LC/MS [41], LC/MS–MS [42], some with a greater mass resolution such as the HPLC-TOF-MS [43]. The use of powerful mass analyzers such as Orbitrap, may lead to the discovery of new structures of this nature [44].
The cannabinols constitute a family of natural products of about 70 compounds, of which the most important are the THC and the CBD [45]. The discovery of the endocannabinoid 1 and endocannabinoid 2 systems, 4 decades ago, awakened the medicinal interest of these substances [46]. These compounds have a high solubility in non-polar solvents and are volatile at the injection temperatures in a gas chromatography equipment, consequently a qualification and quantification of them occur in a very good manner in GC/MS systems [47, 48]. The LC/MS is also useful in the analysis of these substances [49, 50].
Practically all the natural products may be analyzed by means of mass spectrometry, its high sensitivity and detailed structural information, make it an essential tool in research and product development labs.
Equipment with analyzers that have high resolutions can provide us with extremely exact values of molecular ions, and thus being able to differentiate the nature of the molecules.
At present there is a great variety of equipment coupled to LC or GC separation systems, which is ideal for the natural extracts that are generally a mixture of substances of diverse nature. Similarly, the combination of ionization and analyzer techniques, has been able to provide an instrumental variability that currently convert it in a technique highly appreciated for the discovery of new natural structures.
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',metaTitle:"Horizon 2020 Compliance",metaDescription:"General requirements for Open Access to Horizon 2020 research project outputs are found within Guidelines on Open Access to Scientific Publication and Research Data in Horizon 2020. The guidelines, in their simplest form, state that if you are a Horizon 2020 recipient, you must ensure open access to your scientific publications by enabling them to be downloaded, printed and read online. Additionally, said publications must be peer reviewed. ",metaKeywords:null,canonicalURL:null,contentRaw:'[{"type":"htmlEditorComponent","content":"Publishing with IntechOpen means that your scientific publications already meet these basic requirements. It also means that through our utilization of open licensing, our publications are also able to be copied, shared, searched, linked, crawled, and mined for text and data, optimizing our authors' compliance as suggested by the European Commission.
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\n\nMetadata for all publications is also automatically deposited in IntechOpen's OAI repository, making them available through the Open Access Infrastructure for Research in Europe's (OpenAIRE) search interface further establishing our compliance.
\n\nIn other words, publishing with IntechOpen guarantees compliance.
\n\nRead more about Open Access in Horizon 2020 here.
\n\nWhich scientific publication to choose?
\n\nWhen choosing a publication, Horizon 2020 grant recipients are encouraged to provide open access to various types of scientific publications including monographs, edited books and conference proceedings.
\n\nIntechOpen publishes all of the aforementioned formats in compliance with the requirements and criteria established by the European Commission for the Horizon 2020 Program.
\n\nAuthors requiring additional information are welcome to send their inquiries to funders@intechopen.com
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. 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The social, environmental, and economical problems can be omitted by use of renewable energy sources, because these resources are considered as environment-friendly, having no or little emission of exhaust and poisonous gases like carbon dioxide, carbon monooxide, sulfur dioxide, etc. Renewable energy is going to be an important source for power generation in near future, because we can use these resources again and again to produce useful energy. Wind power generation is considered as having lowest water consumption, lowest relative greenhouse gas emission, and most favorable social impacts. It is considered as one of the most sustainable renewable energy sources, followed by hydropower, photovoltaic, and then geothermal. As these resources are considered as clean energy resources, they can be helpful for the mitigation of greenhouse effect and global warming effect. Local employment, better health, job opportunities, job creation, consumer choice, improvement of life standard, social bonds creation, income development, demographic impacts, social bonds creation, and community development can be achieved by the proper usage of renewable energy system. Along with the outstanding advantages of these resources, some shortcomings also exist such as the variation of output due to seasonal change, which is the common thing for wind and hydroelectric power plant; hence, special design and consideration are required, which are fulfilled by the hardware and software due to the improvement in computer technology.",book:{id:"7636",slug:"wind-solar-hybrid-renewable-energy-system",title:"Wind Solar Hybrid Renewable Energy System",fullTitle:"Wind Solar Hybrid Renewable Energy System"},signatures:"Mahesh Kumar",authors:[{id:"309842",title:"Mr.",name:"Kamlesh",middleName:null,surname:"Kumar",slug:"kamlesh-kumar",fullName:"Kamlesh Kumar"}]}],mostDownloadedChaptersLast30Days:[{id:"70874",title:"Social, Economic, and Environmental Impacts of Renewable Energy Resources",slug:"social-economic-and-environmental-impacts-of-renewable-energy-resources",totalDownloads:4715,totalCrossrefCites:25,totalDimensionsCites:48,abstract:"Conventional energy source based on coal, gas, and oil are very much helpful for the improvement in the economy of a country, but on the other hand, some bad impacts of these resources in the environment have bound us to use these resources within some limit and turned our thinking toward the renewable energy resources. The social, environmental, and economical problems can be omitted by use of renewable energy sources, because these resources are considered as environment-friendly, having no or little emission of exhaust and poisonous gases like carbon dioxide, carbon monooxide, sulfur dioxide, etc. Renewable energy is going to be an important source for power generation in near future, because we can use these resources again and again to produce useful energy. Wind power generation is considered as having lowest water consumption, lowest relative greenhouse gas emission, and most favorable social impacts. It is considered as one of the most sustainable renewable energy sources, followed by hydropower, photovoltaic, and then geothermal. As these resources are considered as clean energy resources, they can be helpful for the mitigation of greenhouse effect and global warming effect. Local employment, better health, job opportunities, job creation, consumer choice, improvement of life standard, social bonds creation, income development, demographic impacts, social bonds creation, and community development can be achieved by the proper usage of renewable energy system. Along with the outstanding advantages of these resources, some shortcomings also exist such as the variation of output due to seasonal change, which is the common thing for wind and hydroelectric power plant; hence, special design and consideration are required, which are fulfilled by the hardware and software due to the improvement in computer technology.",book:{id:"7636",slug:"wind-solar-hybrid-renewable-energy-system",title:"Wind Solar Hybrid Renewable Energy System",fullTitle:"Wind Solar Hybrid Renewable Energy System"},signatures:"Mahesh Kumar",authors:[{id:"309842",title:"Mr.",name:"Kamlesh",middleName:null,surname:"Kumar",slug:"kamlesh-kumar",fullName:"Kamlesh Kumar"}]},{id:"42273",title:"Techno-Economic Analysis of Different Energy Storage Technologies",slug:"techno-economic-analysis-of-different-energy-storage-technologies",totalDownloads:8583,totalCrossrefCites:18,totalDimensionsCites:33,abstract:null,book:{id:"2154",slug:"energy-storage-technologies-and-applications",title:"Energy Storage",fullTitle:"Energy Storage - Technologies and Applications"},signatures:"Hussein Ibrahim and Adrian Ilinca",authors:[{id:"145865",title:"Dr.",name:"Hussein",middleName:null,surname:"Ibrahim",slug:"hussein-ibrahim",fullName:"Hussein Ibrahim"}]},{id:"67556",title:"A Review of Hybrid Renewable Energy Systems Based on Wind and Solar Energy: Modeling, Design and Optimization",slug:"a-review-of-hybrid-renewable-energy-systems-based-on-wind-and-solar-energy-modeling-design-and-optim",totalDownloads:2187,totalCrossrefCites:3,totalDimensionsCites:7,abstract:"In this chapter, an attempt is made to thoroughly review previous research work conducted on wind energy systems that are hybridized with a PV system. 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The reported reviewed results in this chapter will be a valuable researchers and practicing engineers involved in the design and development of wind energy systems.",book:{id:"7636",slug:"wind-solar-hybrid-renewable-energy-system",title:"Wind Solar Hybrid Renewable Energy System",fullTitle:"Wind Solar Hybrid Renewable Energy System"},signatures:"Salisu Muhammad Lawan and Wan Azlan Wan Zainal Abidin",authors:[{id:"286205",title:"Dr.",name:"Salisu",middleName:null,surname:"Muhammad Lawan",slug:"salisu-muhammad-lawan",fullName:"Salisu Muhammad Lawan"},{id:"286210",title:"Prof.",name:"Wan Azlan",middleName:null,surname:"Wan Zainal Abidin",slug:"wan-azlan-wan-zainal-abidin",fullName:"Wan Azlan Wan Zainal Abidin"}]},{id:"59381",title:"A Review of Recycling Processes for Photovoltaic Modules",slug:"a-review-of-recycling-processes-for-photovoltaic-modules",totalDownloads:3447,totalCrossrefCites:21,totalDimensionsCites:40,abstract:"The installations of photovoltaic (PV) solar modules are growing extremely fast. 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There is potential to develop new pathways for PV waste management industry development and offer employment and prospects for both public and private sector investors.",book:{id:"6691",slug:"solar-panels-and-photovoltaic-materials",title:"Solar Panels and Photovoltaic Materials",fullTitle:"Solar Panels and Photovoltaic Materials"},signatures:"Marina Monteiro Lunardi, Juan Pablo Alvarez-Gaitan, José I. Bilbao\nand Richard Corkish",authors:[{id:"233229",title:"Dr.",name:"Richard",middleName:null,surname:"Corkish",slug:"richard-corkish",fullName:"Richard Corkish"},{id:"233231",title:"Ms.",name:"Marina",middleName:null,surname:"Monteiro Lunardi",slug:"marina-monteiro-lunardi",fullName:"Marina Monteiro Lunardi"},{id:"242337",title:"Dr.",name:"Juan Pablo",middleName:null,surname:"Alvarez-Gaitan",slug:"juan-pablo-alvarez-gaitan",fullName:"Juan Pablo Alvarez-Gaitan"},{id:"242338",title:"Dr.",name:"Jose I.",middleName:null,surname:"Bilbao",slug:"jose-i.-bilbao",fullName:"Jose I. 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Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"87",type:"subseries",title:"Economics",keywords:"Globalization, Economic integration, Growth and development, International trade, Environmental development, Developed countries, Developing countries, Technical innovation, Knowledge management, Political economy analysis, Banking and financial markets",scope:"\r\n\tThe topic on Economics is designed to disseminate knowledge around broad global economic issues. Original submissions will be accepted in English for applied and theoretical articles, case studies and reviews about the specific challenges and opportunities faced by the economies and markets around the world. The authors are encouraged to apply rigorous economic analysis with significant policy implications for developed and developing countries. Examples of subjects of interest will include, but are not limited to globalization, economic integration, growth and development, international trade, environmental development, country specific comparative analysis, technical innovation and knowledge management, political economy analysis, and banking and financial markets.
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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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