\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5142",leadTitle:null,fullTitle:"Applications and Theory of Analytic Hierarchy Process - Decision Making for Strategic Decisions",title:"Applications and Theory of Analytic Hierarchy Process",subtitle:"Decision Making for Strategic Decisions",reviewType:"peer-reviewed",abstract:"The purpose of this book is to provide an introduction to the theory and applications in the field of decision making, especially focused on Analytic Hierarchy Process, a structured technique for organizing and analyzing complex decisions, based on mathematics and psychology. It was developed by Prof. Thomas L. Saaty in the 1970s and has been extensively studied and refined since then. The idea of the book is to expand the reader’s consciousness to deal with problems regarding the decision making. This book presents some application examples of Analytic Hierarchy. It contains original research and application chapters from different perspectives, and covers different areas such as supply chain, environmental engineering, safety, and social issues. This book is intended to be a useful resource for anyone who deals with decision making problems.",isbn:"978-953-51-2561-7",printIsbn:"978-953-51-2560-0",pdfIsbn:"978-953-51-5147-0",doi:"10.5772/61387",price:139,priceEur:155,priceUsd:179,slug:"applications-and-theory-of-analytic-hierarchy-process-decision-making-for-strategic-decisions",numberOfPages:322,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"7696be005ef87456c3b444052af3a857",bookSignature:"Fabio De Felice, Thomas L. Saaty and Antonella Petrillo",publishedDate:"August 31st 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5142.jpg",numberOfDownloads:24035,numberOfWosCitations:27,numberOfCrossrefCitations:17,numberOfCrossrefCitationsByBook:3,numberOfDimensionsCitations:31,numberOfDimensionsCitationsByBook:3,hasAltmetrics:0,numberOfTotalCitations:75,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 22nd 2015",dateEndSecondStepPublish:"November 15th 2015",dateEndThirdStepPublish:"February 21st 2016",dateEndFourthStepPublish:"April 16th 2016",dateEndFifthStepPublish:"May 16th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"161682",title:"Prof.",name:"Fabio",middleName:null,surname:"De Felice",slug:"fabio-de-felice",fullName:"Fabio De Felice",profilePictureURL:"https://mts.intechopen.com/storage/users/161682/images/system/161682.png",biography:"Fabio De Felice, Ph.D., is a professor in the Department of Engineering, University of Naples “Parthenope,” Italy. He received his Ph.D. in Mechanical Engineering from the University of Cassino and Southern Lazio, Italy. His current research focuses on multi-criteria decision-making analysis (with emphasis on AHP and ANP) and industrial, project, and supply chain management. Currently, he serves as a member of the Scientific Advisory Committee of the International Symposium on the Analytic Hierarchy Process (ISAHP). He is the founder of AHP Academy, which promotes the diffusion of the culture and methodologies of decision making, with reference to those based on the analytic hierarchy process. He is a member of the editorial boards of several international organizations and journals and has authored/co-authored numerous articles in the areas of decision science and business management.",institutionString:"Parthenope University of Naples",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Cassino and Southern Lazio",institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. She has over 160 Scientific Publications in International Journals and Conferences and she is the author of 5 books on Innovation and Decision Making in Industrial Applications and Engineering.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},coeditorTwo:{id:"200437",title:"Dr.",name:"Thomas",middleName:null,surname:"Saaty",slug:"thomas-saaty",fullName:"Thomas Saaty",profilePictureURL:"https://mts.intechopen.com/storage/users/200437/images/4925_n.jpg",biography:"Thomas L. Saaty is the Distinguished University Professor at the University of Pittsburgh. Previously, he worked for the U.S. Government agencies and government-sponsored companies and he was also a professor at the University of Pennsylvania. Prof. Saaty developed the Analytic Hierarchy Process (AHP) for decision-making and its generalization to feedback, the Analytic Network Process (ANP). He published 43 books and more than 300 papers. His latest books are: Group Decision Making: Drawing out and Reconciling Differences: Problem Solving & Decision Making; The Brain: Unraveling the Mystery of How It Works; Creative Thinking and Problem Solving; The Neural Network Process (NNP).",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"433",title:"Decision Making",slug:"decision-making"}],chapters:[{id:"50912",title:"Analytic Hierarchy Process Applied to Supply Chain Management",doi:"10.5772/64022",slug:"analytic-hierarchy-process-applied-to-supply-chain-management",totalDownloads:2491,totalCrossrefCites:3,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Resource allocation (RA) and supplier selection (SS) are two major decision problems regarding supply chain management (SCM). A supply chain manager may solve these problems by considering a single criterion, for instance, costs, customer satisfaction, or delivery time. Applying analytic hierarchy process (AHP), the supply chain manager may combine such criteria to enhance a compromised solution. This chapter presents AHP applications to solve two real SCM problems faced by Brazilian companies: one problem regarding the RA in the automotive industry and another one to SS in a chemical corporation.",signatures:"Valerio Antonio Pamplona Salomon, Claudemir Leif Tramarico and\nFernando Augusto Silva Marins",downloadPdfUrl:"/chapter/pdf-download/50912",previewPdfUrl:"/chapter/pdf-preview/50912",authors:[{id:"137460",title:"Dr.",name:"Fernando",surname:"Marins",slug:"fernando-marins",fullName:"Fernando Marins"},{id:"179921",title:"Dr.",name:"Valerio",surname:"Salomon",slug:"valerio-salomon",fullName:"Valerio Salomon"},{id:"179926",title:"Prof.",name:"Claudemir",surname:"Tramarico",slug:"claudemir-tramarico",fullName:"Claudemir Tramarico"}],corrections:null},{id:"51424",title:"An Analytical Hierarchy Process to Decision Making in Human Blood, Cells, and Tissue Banks",doi:"10.5772/64175",slug:"an-analytical-hierarchy-process-to-decision-making-in-human-blood-cells-and-tissue-banks",totalDownloads:2002,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The decisions are critical in transfusion and transplantation principally because they could affect directly and indirectly the post‐transfusion and post‐transplantation safety. However, the blood, cells, and tissues banks should not be uniquely centered in the satisfaction of receptor (patient) requirements. All the decisions affecting the sustainability of the organization should also be considered. Despite not to be systematically used in these banks, the analytical hierarchy process could be useful for the improvement in the reliability of the decisions. This chapter reviews the basics of the analytical hierarchy process applied to the production of blood, cells, and tissues, and presents a case study that could be interpreted as applicable to other situations in these organizations.",signatures:"Paulo Pereira and Sandra Xavier",downloadPdfUrl:"/chapter/pdf-download/51424",previewPdfUrl:"/chapter/pdf-preview/51424",authors:[{id:"178637",title:"Dr.",name:"Paulo",surname:"Pereira",slug:"paulo-pereira",fullName:"Paulo Pereira"},{id:"185958",title:"Dr.",name:"Sandra",surname:"Xavier",slug:"sandra-xavier",fullName:"Sandra Xavier"}],corrections:null},{id:"51421",title:"A Case Study on the Application of the Analytic Hierarchy Process (AHP) to Assess Agri-Environmental Measures of the Rural Development Programme (RDP 2007–2013) in Slovenia",doi:"10.5772/63924",slug:"a-case-study-on-the-application-of-the-analytic-hierarchy-process-ahp-to-assess-agri-environmental-m",totalDownloads:2254,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The reform of the Common Agricultural Policy (CAP) in 2003 focused mainly on the economic and environmental challenges. The Rural Development Programme 2007–2013, hereafter RDP, being implemented in Slovenia is therefore aiming at promoting proposed activities that help to improve the rural areas. Agri-environmental measures (AEMs) encourage farmers to make an environmental commitment for a period of at least 5 years aiming at preserving the environment and maintaining the countryside. Because of practising environmental friendly production methods, the farmers might be encountered with more costs and reduction of yield. Therefore, payments are made as compensation. Concentrating only on one of the four pillars of the RDP, “Improvement of environment and the countryside”, this paper attempts to assess the Slovenian agri-environmental measures with the help of the multicriteria decision analysis, that is, analytic hierarchy process (AHP) and its supporting software Expert Choice™. In the presented case study, three main criteria and their attributes were determined. With the help of experts (questionnaires), data were collected, which made the assessment possible. The results show that organic fruit, vine and horticultural production are seen as the most important AEM. This is specific for the Republic of Slovenia because of its large amount of area designated as least favoured areas (LFA) that are not suitable for arable farming.",signatures:"Monica Huehner, Črtomir Rozman and Karmen Pažek",downloadPdfUrl:"/chapter/pdf-download/51421",previewPdfUrl:"/chapter/pdf-preview/51421",authors:[{id:"179642",title:"Prof.",name:"Karmen",surname:"Pažek",slug:"karmen-pazek",fullName:"Karmen Pažek"}],corrections:null},{id:"51359",title:"Application of the AHP Method in Environmental Engineering: Three Case Studies",doi:"10.5772/63990",slug:"application-of-the-ahp-method-in-environmental-engineering-three-case-studies",totalDownloads:2163,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The chapter presents the application of the Analytic Hierarchy Process (AHP) method in the field of environmental management. The work shows how to use the results of environmental engineering tools or models as an input for the AHP method. Three case studies are presented: selection of the best municipal solid waste disposal system, assessment of the tap and bottled water consumption on the environment, and selection of the heat pump for the individual home. In the first case study, the AHP analysis was required to assess the environmental impact of waste disposal system. This was done by the use of Integrated Waste Management model (IWM-1), which delivered results aggregated, at the next step, into Life Cycle Analysis (LCA) categories. The obtained results were used in the AHP analysis to choose the best scheme for the waste disposal system. In the second case study, the AHP method was used to evaluate different patterns of water drinking. Obtained results help decision makers in assessing regional and individual environmental impact if the drinking pattern changes. Selected evaluation criteria were solid waste stream, energy consumption, carbon dioxide emission, and Eco-indicator 99 H/A points. The third case study presents the method of heat pump selection. The environmental performance criteria were developed using the criteria of the ecolabeling program. All three case studies are based on real data.",signatures:"Tomasz Stypka, Agnieszka Flaga-Maryańczyk and Jacek Schnotale",downloadPdfUrl:"/chapter/pdf-download/51359",previewPdfUrl:"/chapter/pdf-preview/51359",authors:[{id:"179383",title:"Dr.",name:"Tomasz",surname:"Stypka",slug:"tomasz-stypka",fullName:"Tomasz Stypka"},{id:"179392",title:"Dr.",name:"Agnieszka",surname:"Flaga-Maryańczyk",slug:"agnieszka-flaga-maryanczyk",fullName:"Agnieszka Flaga-Maryańczyk"},{id:"179695",title:"Prof.",name:"Jacek",surname:"Schnotale",slug:"jacek-schnotale",fullName:"Jacek Schnotale"}],corrections:null},{id:"51754",title:"Analytic Hierarchy Process Application in Different Organisational Settings",doi:"10.5772/64511",slug:"analytic-hierarchy-process-application-in-different-organisational-settings",totalDownloads:2163,totalCrossrefCites:7,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Purpose – The purpose of this paper is to apply AHP in two case settings which include (i) evaluation/selection of maintenance policy (ii) sustainability factors of employee suggestion schemes.",signatures:"Damjan Maletič, Flevy Lasrado, Matjaž Maletič and Boštjan\nGomišček",downloadPdfUrl:"/chapter/pdf-download/51754",previewPdfUrl:"/chapter/pdf-preview/51754",authors:[{id:"178809",title:"Prof.",name:"Boštjan",surname:"Gomišček",slug:"bostjan-gomiscek",fullName:"Boštjan Gomišček"}],corrections:null},{id:"51007",title:"AHP‐Aided Evaluation of Logistic and Transport Solutions in a Seaport",doi:"10.5772/63686",slug:"ahp-aided-evaluation-of-logistic-and-transport-solutions-in-a-seaport",totalDownloads:1773,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"The chapter reports on the application of the analytic hierarchy process (AHP) to a strategic decision in the transport sector, concerning the reconfiguration of the railway infrastructure of the seaport of Trieste. The proposed solutions should not only solve some technical and operational problems of the terminal, but they could allow the port to be included in the Trans‐European Network‐Transport Programme (TEN‐T), promoted by the European Union and aimed to develop the Trans‐European Networks of Transport. Accordingly, the selection of the solution with the most promising potential to satisfy the goals of the TEN‐T policy is a fundamental stage of the project. The case study is an actual AHP application to an evaluation process concerning a pre‐feasibility study of strategic solutions in the logistics and transport fields. Some practical aspects regarding the application of the AHP and the building of the model, when several stakeholders are involved in the decision process, are highlighted and discussed.",signatures:"Cristian Giacomini, Giovanni Longo, Alice Lunardi and Elio Padoano",downloadPdfUrl:"/chapter/pdf-download/51007",previewPdfUrl:"/chapter/pdf-preview/51007",authors:[{id:"181593",title:"Prof.",name:"Elio",surname:"Padoano",slug:"elio-padoano",fullName:"Elio Padoano"},{id:"182135",title:"Prof.",name:"Giovanni",surname:"Longo",slug:"giovanni-longo",fullName:"Giovanni Longo"},{id:"185623",title:"Dr.",name:"Cristian",surname:"Giacomini",slug:"cristian-giacomini",fullName:"Cristian Giacomini"},{id:"185625",title:"BSc.",name:"Alice",surname:"Lunardi",slug:"alice-lunardi",fullName:"Alice Lunardi"}],corrections:null},{id:"51701",title:"Prioritizing Human Factors in Emergency Conditions Using AHP Model and FMEA",doi:"10.5772/64411",slug:"prioritizing-human-factors-in-emergency-conditions-using-ahp-model-and-fmea",totalDownloads:1925,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"One of the most critical issues related to safety in industrial plant is to manage accidents that occur in industries. In general, the causes of accidents are twofold: the presence of dangerous equipment and human errors. The aim of this study is to propose a novel approach to ensure safety in emergency conditions in industrial plant considering both of these factors. The proposed idea aims to integrate the human reliability analysis (HRA) and the failure modes and effects analysis (FMEA). The human errors and failure modes are categorized using a multicriteria approach based on analytic hierarchy process (AHP). The final aim is to present a novel methodological approach based on AHP to prioritize actions to carry out in emergency conditions taking into account both qualitative and quantitative factors. A real case study is analyzed. The analysis allowed to identify possible failure modes connected with human error process.",signatures:"Fabio De Felice, Antonella Petrillo and Domenico Falcone",downloadPdfUrl:"/chapter/pdf-download/51701",previewPdfUrl:"/chapter/pdf-preview/51701",authors:[{id:"161682",title:"Prof.",name:"Fabio",surname:"De Felice",slug:"fabio-de-felice",fullName:"Fabio De Felice"},{id:"181603",title:"Dr.",name:"Antonella",surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo"},{id:"171487",title:"Prof.",name:"Domenico",surname:"Falcone",slug:"domenico-falcone",fullName:"Domenico Falcone"}],corrections:null},{id:"51061",title:"Disaster Risk Assessment Developing a Perceived Comprehensive Disaster Risk Index: The Cases of Three Chilean Cities",doi:"10.5772/62994",slug:"disaster-risk-assessment-developing-a-perceived-comprehensive-disaster-risk-index-the-cases-of-three",totalDownloads:1523,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"A significant increase in the impacts caused by extreme events, of both natural and anthropogenic origin, has been observed in recent decades at a global scale. Chile is no exception to this dynamic. Hazards of various origins and their interactions with socioeconomic, urban, and demographic changes, combined with governance issues have led to a significant risk increase. An accurate assessment of this risk is a significantly complex problem and a holistic approach is required. To address this issue, a multi‐criteria decision model has been designed, using the analytic hierarchy process (AHP), which includes qualitative and quantitative variables. The model can be adapted to different contexts, generating a comparable metrics (commensurable) for different cities. The three cities analyzed in this study (Iquique, Puerto Montt, and Puerto Varas) show different levels of risks as a result of a synergic and dynamic combination of factors related not only with natural and physical conditions but also particularly with the variables related to social vulnerability and resilience capacity.",signatures:"Carmen Paz Castro, Juan Pablo Sarmiento and Claudio Garuti",downloadPdfUrl:"/chapter/pdf-download/51061",previewPdfUrl:"/chapter/pdf-preview/51061",authors:[{id:"179811",title:"Prof.",name:"Claudio",surname:"Garuti",slug:"claudio-garuti",fullName:"Claudio Garuti"}],corrections:null},{id:"51043",title:"Framework for Optimal Selection Using Meta‐Heuristic Approach and AHP Algorithm",doi:"10.5772/63991",slug:"framework-for-optimal-selection-using-meta-heuristic-approach-and-ahp-algorithm",totalDownloads:1316,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Many real‐life decisions are focused on selecting the most preferable combination of available options, by satisfying different kinds of preferences and internal or external constraints and requirements. Focusing on the well‐known analytical hierarchical process (AHP) method and its extension CS‐AHP for capturing different kinds of preferences over two‐layered structure (including conditionally defined preferences and preferences about dominant importance), we propose a two‐layered framework for identifying stakeholders’ decision criteria requirements and employ meta‐heuristic algorithms (i.e., genetic algorithms) to optimally make a selection over available options. The proposed formal two‐layered framework, called OptSelectionAHP, provides the means for optimal selection based on specified different kinds of preferences. The framework has simultaneously proven optimality applied in software engineering domain, for optimal configuration of business process families where stakeholders’ preferences are defined over quality characteristics of available services (i.e., QoS attributes). Furthermore, this domain of application is characterized with uncertainty and variability in selection space, which is proven and does not significantly violate the optimality of the proposed framework.",signatures:"Ramo Šendelj and Ivana Ognjanović",downloadPdfUrl:"/chapter/pdf-download/51043",previewPdfUrl:"/chapter/pdf-preview/51043",authors:[{id:"178317",title:"Dr.",name:"Ivana",surname:"Ognjanovic",slug:"ivana-ognjanovic",fullName:"Ivana Ognjanovic"},{id:"182140",title:"Prof.",name:"Ramo",surname:"Šendelj",slug:"ramo-sendelj",fullName:"Ramo Šendelj"}],corrections:null},{id:"51164",title:"Evaluation of Growth Simulators for Forest Management in Terms of Functionality and Software Structure Using AHP",doi:"10.5772/63925",slug:"evaluation-of-growth-simulators-for-forest-management-in-terms-of-functionality-and-software-structu",totalDownloads:1735,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"A range of computer models exist for simulating forest growth, with different model functions, spatial resolutions and regional calibration specifications. Choosing a suitable simulator is difficult due to its abundance and complexity. The aim of the project is to evaluate a simulator that could be adapted to conditions in Switzerland and used to support decision‐making processes in both forest enterprises and scientific contexts. Fourteen potentially suitable forest growth simulators were identified through a literature review, which was then narrowed down to four: BWINPro, SILVA, MOSES and PrognAus. In the second phase, these were systematically evaluated in terms of functionality and software structure using AHP, in order to identify a suitable simulator. The AHP evaluation entailed: (1) determining the decision criteria and hierarchy, (2) performing pairwise comparisons and calculating the utility values and (3) conducting a sensitivity analysis. AHP was found to provide a transparent, verifiable evaluation process for simulator selection. This enabled a critical argumentation and assessment of the simulators. In the third phase, not covered by this article, the selected simulator will be parametrised for Swiss conditions and incorporated into an overarching decision‐support system for forest planning and management.",signatures:"Clemens Blattert, Renato Lemm, and Oliver Thees",downloadPdfUrl:"/chapter/pdf-download/51164",previewPdfUrl:"/chapter/pdf-preview/51164",authors:[{id:"178803",title:"M.Sc.",name:"Clemens",surname:"Blattert",slug:"clemens-blattert",fullName:"Clemens Blattert"}],corrections:null},{id:"51373",title:"Measuring in Weighted Environments: Moving from Metric to Order Topology (Knowing When Close Really Means Close)",doi:"10.5772/63670",slug:"measuring-in-weighted-environments-moving-from-metric-to-order-topology-knowing-when-close-really-me",totalDownloads:1207,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter addresses the problem of measuring closeness in weighted environments (decision-making environments). This chapter show the importance of having a trustworthy cardinal measure of proximity in weighted environments. A weighted environment is a nonisotropic structure where different directions (axes) may have different importance (weight), thus there exist privilege directions. In this kind of structure, it would be very important to have a cardinal reliable index that can say the closeness or compatibility of a set of measures of one individual with respect to the group or to anyone other. Common examples of this structure are the interaction between factors in a decision-making process (system-values interaction), matching profiles, pattern recognition, and any situation where a process of measurement with qualitative variables is involved.",signatures:"Claudio Garuti",downloadPdfUrl:"/chapter/pdf-download/51373",previewPdfUrl:"/chapter/pdf-preview/51373",authors:[{id:"179811",title:"Prof.",name:"Claudio",surname:"Garuti",slug:"claudio-garuti",fullName:"Claudio Garuti"}],corrections:null},{id:"51121",title:"Combining AHP Method with BOCR Merits to Analyze the Outcomes of Business Electricity Sustainability",doi:"10.5772/64042",slug:"combining-ahp-method-with-bocr-merits-to-analyze-the-outcomes-of-business-electricity-sustainability",totalDownloads:1493,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Over the last three decades, many researchers and decision makers have investigated separately the issues of economic growth, profitability, and quality of life when thinking about business electricity sustainability. The correlations between these paradigms still remain at the stage of discussions, debates, and forecasts as a reaction to the occurred conflicts and disasters. There is a lack of real encryption that demonstrates their interactions. It is useful to materialize the expectations of stakeholders by mathematical modeling and providing answers to specific wants of each society according to its financial resources, its concrete societal objectives, especially to which kind of energy legacy it wants to contribute to future generations. It is imperative that experts assist decision makers, through transparent methods that seek consensus. To this end, the analytic hierarchy process (AHP) method was proposed as it has proven its efficiency in many areas of human activities. The outcomes were analyzed using this method, and the findings were compared and recommendations were made using other multi‐criteria decision‐making (MCDM) methods. As for energy sustainability, it is imperative to move toward renewable energy resources while trying to hold together the benefits, opportunities, costs, and risks (BOCR). We have retained that status quo is not sustainable.",signatures:"Rabah Medjoudj, Fairouz Iberraken and Djamil Aissani",downloadPdfUrl:"/chapter/pdf-download/51121",previewPdfUrl:"/chapter/pdf-preview/51121",authors:[{id:"182165",title:"Dr.",name:"Rabah",surname:"Medjoudj",slug:"rabah-medjoudj",fullName:"Rabah Medjoudj"},{id:"182166",title:"Ms.",name:"Fairouz",surname:"Iberraken",slug:"fairouz-iberraken",fullName:"Fairouz Iberraken"},{id:"182167",title:"Prof.",name:"Djamil",surname:"Aissani",slug:"djamil-aissani",fullName:"Djamil Aissani"}],corrections:null},{id:"51811",title:"A Prototype AHP System for Contractor Selection Decision",doi:"10.5772/64425",slug:"a-prototype-ahp-system-for-contractor-selection-decision",totalDownloads:1994,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Contractor selection process is generally believed to be marred with lots of bias in most developing nations, which sometimes leads to incompetent contractor being selected because it is based mainly on human experience and feelings. In particular, in a culturally biased country like Nigeria where most contractors’ selection process is not based on performance but rather on whom you know, not paying attention to important factor/criteria but rather on selfish personal gains, which directly or indirectly affect the public in different forms could have some negative effects on projects. The failure of managers to be objective in decision-making in regard to contractor selection has great consequences for the government as well as corporate organizations in terms of cost incurred, delivery time, and impact on the general welfare of the people. Hence, there is a need for managers to be interested in the selection of contractors, suppliers of materials, equipment, and services as failure or inefficiency on the part of the contractor that could affect the well-being of the people negatively and damage the performance rating of the government. Developing an appropriate model to address the problem of poor contractor evaluation would, no doubt, be a great relief in the selection of contractors. This chapter presents a prototype system for contractor evaluation decision.",signatures:"Emmanuel O. Oyatoye and Adedotun A. 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Efficient Desalination",subtitle:null,reviewType:"peer-reviewed",abstract:"Due to industrialization and increasing population, water demand continues to grow at compound annual growth rates of 7–8%. The current demand is also intensified by increased water utilization for hand washing due to the COVID-19 pandemic. Today, around 20,000 desalination plants operating around the world produce 100 million cubic meters of water per day to supply 300 million people. These desalination plants are a major source of environmental and marine pollution due to their inefficient operation. Scientists and researchers are encouraged to develop out-of-box solutions to achieve future sustainability. This book addresses key challenges related to the desalination industry.",isbn:"978-1-83968-877-5",printIsbn:"978-1-83968-876-8",pdfIsbn:"978-1-83968-878-2",doi:null,price:119,priceEur:129,priceUsd:155,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"ca25e9eca70d54deb503d2663f75218c",bookSignature:"Dr. Muhammad Wakil Shahzad, Dr. Mike Dixon, Dr. Giancarlo Barassi, Prof. Ben Bin Xu and Dr. Yinzhu Jiang",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10682.jpg",keywords:"Conventional Desalination, Processes Limitations, Desalination CAPEX and OPEX, Innovative Processes, Hybrid Systems, Solar Desalination, Wind-RO, Standard Primary Energy, Performance Ratio, Sustainable Desalination, Environment Friendly, Low Cost",numberOfDownloads:324,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 8th 2021",dateEndSecondStepPublish:"April 5th 2021",dateEndThirdStepPublish:"June 4th 2021",dateEndFourthStepPublish:"August 23rd 2021",dateEndFifthStepPublish:"October 22nd 2021",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a year",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Dr. Shahzad is a pioneering researcher in hybrid desalination processes, he received many international awards including the global innovation award in water 2020, served as IDA-YLP regional coordinator, and is a holder of 9 registered patents. He is also a member of two spin-off companies.",coeditorOneBiosketch:"Dr. Dixon has a Ph.D. in Chemical Engineering from the University of Adelaide and business training from Stanford University. He has more than 60 publications in international journals and has been an Editor of the International Desalination Association Journal.",coeditorTwoBiosketch:"Dr. Barassi returned to Chile, after finishing his Ph.D. in Chemistry in New Zealand, and started his own company H2OPR. He is currently working at FEDCO USA as a leader in hydraulic solutions for the desalination industry.",coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"174208",title:"Dr.",name:"Muhammad Wakil",middleName:null,surname:"Shahzad",slug:"muhammad-wakil-shahzad",fullName:"Muhammad Wakil Shahzad",profilePictureURL:"https://mts.intechopen.com/storage/users/174208/images/system/174208.jpg",biography:"Dr. Muhammad Wakil Shahzad is a senior lecturer in the Mechanical and Construction Engineering Department, Northumbria University (NU), Newcastle Upon Tyne, United Kingdom.\nHe is an expert in hybrid desalination processes and renewable energy applications for water treatment. He has won many international awards for his innovative desalination cycle, including the National Energy Globe Award Saudi Arabia 2021, Sustainability Medal 2020, Global Innovation Award 2020, National Energy Globe Award Saudi Arabia 2020 and 2019, Excellence and Leadership Award 2019, and IDA Environmental & Sustainability Award 2019. His research has been highlighted at Yahoo Business, Nature Middle East, Arab News, and many other national and international platforms.\nDr. Shahzad has a Ph.D. in Mechanical Engineering from the National University of Singapore and research training from KAUST Saudi Arabia. He has extensive experience in intellectual property development and the commercialization of innovative technologies. He holds eleven international patents. To date, he has published two books, seventeen book chapters, more than seventy peer-reviewed journal papers, and more than 110 conference papers. He also received three best paper awards in international conferences. He is an editor of International Communications in Heat and Mass Transfer, an editorial board member of SN Applied Sciences, and a guest editor for topical collections. He is a Chartered Engineer and a mentor for International Desalination Association’s Young Leader Program (IDA-YLP). He is also a member of many professional organizations, including the Institute of Mechanical Engineers, International Desalination Association (IDA), International Water Association (IWA), and American Society of Mechanical Engineers (ASME).",institutionString:"Northumbria University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"11",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Northumbria University",institutionURL:null,country:{name:"United Kingdom"}}}],coeditorOne:{id:"351853",title:"Dr.",name:"Mike",middleName:null,surname:"Dixon",slug:"mike-dixon",fullName:"Mike Dixon",profilePictureURL:"https://mts.intechopen.com/storage/users/351853/images/system/351853.png",biography:"Dr. Mike Dixon is a desalination and water treatment technology professional with 15 years’ experience working with membrane and thermal technologies in Australia, North America, the Middle East, the Caribbean, and Asia. He has worked across the entire value chain with technology manufacturers, water utilities, oil and gas companies, pharmaceutical companies, and research hubs.\nAs the current Chief Technology Officer of WaterNEXT (a water business accelerator based in Calgary, Canada), Dr. Dixon’s responsibilities include technology assessment and intake assessment. He is also a senior technical advisor, and on the founding team, of MIT start-up Sandymount Technologies.\nPrior to WaterSMART, Dr. Dixon was Applications Development Manager for NanoH2O, a global provider of reverse osmosis membranes that leveraged UCLA developed nanotechnology developed at the University of California, Los Angeles, to lower the cost of desalination with more than 300 installations in 40+ countries in the three years from market launch. LG Chem acquired NanoH2O in 2014. He was also R&D Engineer for the 300,000 m3/day Adelaide Desalination Plant.\nDr. Dixon has a Ph.D. in Chemical Engineering from the University of Adelaide, Australia, and business training from Stanford University, California. He is experienced with the development of intellectual property and the commercialization of new technologies. He has more than sixty publications in international journals and is an author of several books and book chapters. He has been an editor of the International Desalination Association Journal and a reviewer for the Journal of Membrane Science, Desalination and Water Research. He was National President of the Young Water Professionals for the Australian Water Association and in 2012 won the prestigious International Desalination Association Fellowship Award.",institutionString:"Synauta Inc.",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"351875",title:"Dr.",name:"Giancarlo",middleName:null,surname:"Barassi",slug:"giancarlo-barassi",fullName:"Giancarlo Barassi",profilePictureURL:"https://mts.intechopen.com/storage/users/351875/images/system/351875.png",biography:"After obtaining his Ph.D. in Chemistry in New Zealand, Dr. Giancarlo Barassi returned to his home country of Chile and started his own company, H2OPRO. His business sells projects and equipment for Culligan, Voltea, and FEDCO in Chile and Peru. He has hands-on experience in designing, commissioning, and troubleshooting reverse osmosis plants for industrial, agriculture, and haemodialysis applications. Dr. Barassi joined the pump and ERD manufacturer, FEDCO, in September 2017 where he collaborated in sales and business development in the Western Hemisphere until 2021. He was appointed the co-chair of the Young Leader Program at the International Desalination Association for the 2019–2022 term where he promotes benefits to young professionals in the industry. In 2022, he joined Aquatech International LLC, as the Desalination and Reuse Market Manager, where he oversees all desalination and reuse projects.\nHe is currently based in Tampa, FL, USA.",institutionString:"FEDCO USA",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:{id:"417448",title:"Prof.",name:"Ben Bin",middleName:null,surname:"Xu",slug:"ben-bin-xu",fullName:"Ben Bin Xu",profilePictureURL:"https://mts.intechopen.com/storage/users/417448/images/system/417448.png",biography:"Dr. Ben Bin Xu is a Full Professor of Materials and Mechanics, Department of Mechanical and Construction Engineering (MCE), Northumbria University (NU), Newcastle Upon Tyne, United Kingdom. and leads the research group of the Smart Materials and Surfaces Lab. He obtained his Ph.D. in Mechanical Engineering at Heriot-Watt University, Scotland, in 2011 and subsequently worked as a postdoc researcher at the University of Massachusetts Amherst (2011–2013). His research interests include advanced materials, smart surfaces, energy materials/systems, thin films, flexible electronics, and microengineering. He has published more than 120 journal articles and 3 book chapters. He has four patents to his credit. He has given more than sixty invited talks and won multiple awards, such as the Outstanding Paper Award at the 2018 IEEE International Flexible Electronics Technology Conference, the 2016 Young Investigator Award from the International Polymer Networks Group, and the 3rd prize in the 2016 EPSRC photo competition, among others. \r\n\r\nDr. Xu is a fellow of the Royal Society of Chemistry (RSC), Institute of Materials, Minerals, and Mining (IoM3), and Royal Society for the Encouragement of Arts, Manufactures and Commerce (RSA). He is also a Chartered Scientist and Chartered Engineer. 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When we think about the archaeology of the Pleistocene in the Americas, we can only point to a few sites that are not dated from the very end of that period. This is because the American continent only started to be densely occupied after 13,000 BP, when the Pleistocene was ending. In South America, there are only four places known to this day that present strong evidence that some people settled the continent before 13,000 BP: the Serra da Capivara region, in Northwestern Brazil, which has sites containing simple tools of quartzite pebbles made by direct percussion (choppers), the oldest one being Boqueirão da Pedra Furada, dating around 50,000 BP [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11]; Monte Verde site, in central Chile, where choppers and flakes are presenting dates older than 33,000 BP [12]; Santa Elina site, in Midwestern Brazil, where retouched limestone flakes and polished pendants made of
It was only around 13,000 cal BP, during the Pleistocene/Holocene transition, that the continent started to be densely occupied—and this is what we may call the “second phase” of America’s “human settlement.” The first studies of Paleoindians in the Eastern part of South America, which is the focus of this article, emerged in the 1960s with the second generation of academic archaeologists in Brazil. Before them, the only systematic archaeological research in the country was carried out by the
During the 1970s, Brazilian archaeologist Pedro Ignácio Schmitz [17, 18, 19] discovered several Paleoindian sites in the Serranópolis region, Midwestern Brazil, dating around 10,700 BP and presenting hundreds of unifacial plan-convex tools. Schmitz gave a name to these tools:
In Brazil, the term
The Umbu tradition was supposed to be the opposite of the Itaparica tradition, since there were no
In the same area that the Umbu tradition was found, there was a second, contemporary tradition defined based on the presence of large, thick bifaces, some of them boomerang-shaped. This culture was first referred as the Altoparanaense Tradition [33, 34] and later renamed as the Humaitá tradition [35, 36]. However, this tradition was discarded from Brazilian archaeological literature at the end of the 2010s [37], since new findings revealed that typical Umbu and Humaitá tools were now being found in the same contexts. This meant there was only one tradition to associate new Paleoindian findings with stemmed points in southern Brazil and nearby regions.
\nMany critiques were made of the concept of the Umbu tradition just after a large quantity of assemblages had been aggregated into it [38, 39, 40, 41, 42, 43], especially about the fact that the presence of stemmed points was the only attribute used to define it. In fact, until the end of the 2010s, no study was ever made to confirm this supposed cultural homogeneity in assemblages associated to the Umbu tradition. Added to this question, no researcher outside Brazil ever associated stemmed points to the Umbu tradition—even though Uruguay, Paraguay, and Argentina were supposedly part of it. One of the critiques also highlighted that Uruguayan archaeologists were defining the same points that Brazilian archaeologists were calling Umbu tradition to the Tigre tradition [43]. Tigre points were not the only ones found in levels related to the Pleistocene–Holocene transition. In fact, a good chronology for at least three types of stemmed points defined three different lithic industries [44]: Fell industry, Tigre industry, and Pay Paso industry (Figure 1).
\nThe distribution of Paleoindian cultures in eastern South America between 13,000 and 8000 cal BP. Ls, Lagoassantense culture. Rc, Rioclarense lithic industry. Tu, tunas lithic industry. Ga, Garivaldinense lithic industry. T/C, Tigre tradition and Catalanense lithic industry coverage areas. PP, pay Paso lithic industry. Sites outside this chronological range were not considered.
Since the beginning of the current decade, Brazilian archaeologists also started to verify the validity of this supposed cultural homogeneity in Umbu tradition sites. Studies on geometric morphometry [45, 46, 47] and technology [48, 49] on Umbu-associated stemmed points revealed that these artefacts are indeed traditional, since they persist for millennia. However, these studies also revealed that they are heterogeneous in space, since regional cultural patterns revealed the existence of at least three lithic industries in the supposed Umbu tradition coverage area: Rioclarense industry, Tunas industry, and Garivaldinense industry (Figure 1). The Umbu tradition was declared to be no longer a valid concept [41, 48, 49], and none of these identified industries are related to the previously associated Humaitá tradition. In fact, no studies have ever been made in order to verify if there is any cultural pattern of point types associated to boomerang-shaped bifaces.
\nThe Fell industry is named after the first site to present what are now called Fell points (a.k.a. Fishtail points): the Fell Cave site, in southern Patagonia (Chile) [50, 51, 52, 53]. Since then, many sites found in the Southern Cone, which extends from the extreme south of Chile and Argentina to the Northern parts of Uruguay, presented Fell points dating back to 11,000 BP (13,000 cal BP) [54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90]. In Eastern South America, specifically Uruguay, the Fell industry disappeared around 10,000 BP (12,000 cal BP) [82], but it is not clear if this is the case for all regions. Blade technology is also observable in some of these sites, even though the cores are not found.
\nThe Fell point was initially defined only by its shape, but recent studies have been defining it based on more accurate technological aspects [81, 82, 83, 84, 85, 86]. The Fell points are defined by the bifacial thinning reduction method by percussion technique followed by the fluting technique—the removal of a long flake from the base—and finished by retouch in order to form convex edges in the body and the typical “fish tail” shape of the stem that is usually ca. 20 mm wide. Miniature versions of Fell points can also be found in Eastern Argentina (Pampas region) which are basically thin flakes with retouch that imitates the general shape of the traditional Fell point. These miniatures present no bifacial thinning or fluting. The smaller Fell points may also be the result of body reshaping. Whatever the reason is for the smaller versions, they tend not to have well-delineated wings.
\nFell points have also been found in other distant parts of South America, like meridional Brazil [87, 88], the equatorial Andes [55], and even the Caribbean sea of Venezuela [71], but they do not have a clear context since they usually constitute surface finds by local habitants. Brazilian Fell points usually differ from those found in other parts of South America because they lack the fluting technique (Figure 2: 12).
\nExamples of formal artefacts affiliated to Paleoindian industries in eastern South America during the Pleistocene–Holocene transition, previously associated to Itaparica or Umbu traditions. (1 and 2) Rioclarense points on flint (Alice Boer site). (3 and 4) Star points on flint (Tunas site). (5–7) Garivaldinense points on silicified sandstone (Garivaldino site). (8) Montenegro point on silicified sandstone (Garivaldino site). (9) Brochier point on agate (Garivaldino site). (10 and 11) Rioclarense lesmas on silicified sandstone (Caetetuba site). (12) un-fluted fell point on flint (unclear context from Mauá municipality, eastern São Paulo state, Brazil). Scale bar is the same for all artefacts in the figure. All drawings by the author.
The Tigre tradition, the Catalanense industry, and the Pay Paso industry are all found in Uruguay. It is not yet clear yet when these industries appeared and disappeared, since there are some definition problems in the Uruguayan literature.
\nThe Tigre tradition got its name due the Tigre River, where the first sites associated to it were found, including the Tigre site, where the oldest date for this tradition was obtained: 10,420 ± 90 BP (12,553–11,841 cal BP) [42, 43]. Tigre points have never been well-defined and are usually described in the literature as presenting bifacial reduction, a triangular body, and a convex stem [44, 82], regardless of the presence of bifurcated stems in points associated to this same tradition [43]. Some of these features are the same as those found in the Garivaldinense points of Southern Brazil, but the lack of published data on Uruguayan point technology makes it hard to compare and verify if both Garivaldinense and Tigre points are actually the same.
\nThe Catalanense industry is named after the Catalán Chico River, where the first sites associated to it were found, although it extends across other regions of Uruguay [91, 92, 93, 94, 95, 96, 97]. Its chronological range would fit between 9000 and 7000 BP (11,000 and 8500 cal BP), being defined by the presence of large retouched flakes in the initial period and an increase of discoidal cores and retouched blades in the latest period [43].
\nThe Pay Paso industry comes from the Pay Paso site, the first one to be associated to it, and the oldest date for this industry is 9585 ± 25 BP (11,081–10,711 cal BP) [82]. The main artefact related to this industry is the Pay Paso point type, defined as having a triangle body with convex edges, bifurcated stem, and bifacial technology. Bladelets are also found in this industry. Pay Paso industry studies are quite recent, and more research needs to be done in order to better understand its chronological and geographical range.
\nIn sum, more technological studies are still necessary in Uruguayan archaeology in order to better understand these first lithic industries and the possible relationships between them and the other ones found in Brazilian territory.
\nThe Rioclarense industry is named after the region of Rio Claro, in central São Paulo State, where it was first identified by Tom Miller Jr. in the 1960s [98, 99]. Since stemmed points were part of the Rio Claro tradition, it was also aggregated into the Umbu tradition in the early 1990s [35], regardless of the fact that not all its phases presented stemmed points and that
As mentioned before, recent studies revealed morphological and technological differences between the previously Umbu tradition-associated assemblages. The Rio Claro tradition has now been redefined as the Rioclarense lithic industry due the presence of both
The Rioclarense point type is defined by a triangle-shaped body with straight edges and wings, an ovalate stem, and two technological types of reduction: (a) bifacial reduction by selective and trespassed flakes removed by percussion (Figure 2: 2) and (b) bifacial reduction by parallel flaking by pressure and no retouch, followed by retouch of the active edges (Figure 2: 1). By selective we refer to the lack of a systematical diachrony of the flake negatives, and by trespassed we refer to negatives that trespass the middle of the piece in order to make it thinner (in proportion to the width).
\nThe presence of
The Tunas industry has never been identified by another name, except by the Umbu tradition [101]—since all stemmed points were directly associated to it since the late 1980s. The name of the industry is related to the Tunas Rock Shelter site, where it was defined [48, 49]. It is found in the Eastern part of Paraná state, Brazil, and presents blade cores, lesminas, and star-type points. The oldest site associated to the industry is in fact the Tunas Rock Shelter itself, dating back to 9630 ± 40 BP (11,134–10,744 cal BP). It is still not clear when this industry disappeared, but in the Tunas Rock Shelter site, this industry is only present until 7170 ± 60 BP (8152–7795 cal BP). After that, a totally different lithic technology replaces it [48].
\nThe star point type is defined by the triangle-shaped body with straight or concave active edges, a bifurcated stem, and bifacial reduction by convergent trespassed pressure flaking (Figure 2: 3, 4). Blade cores are rare in Brazilian archaeology, but they are present in the Tunas industry, and one of the main types of tools produced by those cores are the lesminas—unifacially retouched blades or blade fragments presenting less than 7 cm length with edges that are appropriate as scrapers. This same technology seems to be present in other sites from Eastern Paraná state.
\nThe Garivaldinense industry was also one of those industries that were masked by the concept of the Umbu tradition. Its name comes from the site where it was first defined: the Garivaldino site, in mid-eastern Rio Grande do Sul State, Brazil. The oldest dates for the industry also come from this site: 9430 ± 360 BP (11,772–9625 cal BP) [48]. It is not clear when this industry disappeared, since the most recent layers of the Garivaldino site itself presents the same material and the same point types since its oldest layers [48, 102]. The most recent layers have not been dated yet, but they are in the same context as some Taquara Tradition pottery fragments [103], indicating that its occupation lasted at least until the Late Holocene. In technological terms, three point types were identified in this industry: Garivaldinense, Montenegro, and Brochier types. Sites presenting these same types of points can be found in mid-eastern Rio Grande do Sul State.
\nThe Garivaldinense point type is defined by its triangle-shaped body with irregular or straight active edges and straight wings, straight or bifurcated stems, and three distinct technological methods of production: (a) bifacial reduction by selective and trespassed percussion or pressure flaking, followed by bifacial retouch by pressure flaking (Figure 2: 5); (b) bifacial reduction by convergent non-trespassed percussion or pressure flaking, followed by bifacial retouch by pressure flaking (Figure 2: 6); and (c) thin flakes bifacially retouched by pressure (Figure 2: 7). Some of these points are clearly recycled and turned into scrapers, with unifacial retouch of the body forming a convex edge.
\nThe Montenegro point type is defined by its triangle blade-shaped bodies with serrated edges, small bifurcate stems, and systematic bifacial parallel reduction forming a vertical central rib in the artefact body. Pressure flaking always starts from the extremities and finishes in the middle of the point (Figure 2: 8). This seems to be a logical strategy to avoid leaving the middle of the point thinner than the rest and breaking the point during pressure flaking. The ones with a triangle-shaped, shorter body seem to be broken and reworked, due the diachrony of the body negatives.
\nThe Brochier point type is defined by having no stem and wings, being small, and presenting a tapered or lanceolate shape formed by bifacial or unifacial retouch by pressure flaking. They rarely present reduction, since thin agate flakes are used as blanks most of the time (Figure 2: 9).
\nThe Lagoassantense Paleoindian culture gets its name from the name of the region where it was first defined. The region of Lagoa Santa, in Southeastern Brazil, was a target of archaeological and paleontological studies ever since Danish researcher Peter W. Lund visited the region in the nineteenth century [104]. However, it was only in the 1970s that the region started to be systematically studied by a French-Brazilian program led by Annette Laming-Emperaire [105]. Unfortunately, these studies were suddenly interrupted by the unfortunate case of her death, but they were responsible for the discovery of Lagoa Santa and Luzia—the oldest human skeleton known in the Americas until then. It was only in the 2010s that new systematic research in the area was carried out, led by Walter Neves [106], including interdisciplinary analyses of the material culture, such as fauna [107, 108], human skeletons, and burials [109, 110, 111], lithic industry [112, 113, 114, 115, 116, 117], micro residues [20, 118, 119], and bone industry [120, 121]. Thanks to this research, specific cultural patterns were identified for the region that persisted from the Pleistocene–Holocene transition until some centuries before the Portuguese conquest. The Lapa do Santo site, for example, that presents the best chronology dates to between 10,490 ± 50 BP (12,552–12,057 cal BP) and 790 ± 40 BP (739–571 cal BP).
\nThe Lagoassantense lithic industry was clearly not taken into account by the previously proposed Itaparica-Umbu traditions model, since it does not present
The Lagoassantense lithic industry is defined by the debitage of small crystal quartz flakes (Figure 3: 3) using the diagonal slicing core (Figure 3: 1) and the opposite platform core methods (Figure 3: 2) and by the low production of ground axes [94]. These are the oldest records for ground axe blades in the Americas (Figure 3: 4). The lithic industry is also defined by the persistence of making those microliths in the exact same way for at least 8000 years [122], considering that crystal quartz is not a common raw material in the Lagoa Santa region, and other tools (bigger and more complex) could be produced using other types of raw material, like high-quality quartzite, that could be easily found in the area. In this sense, the cultural norm for using small crystals defined the technological limitations of the industry.
\nTypical artefacts of the Lagoassantense industry from the Pleistocene–Holocene transition. All examples are from Lapa do Santo site, except the bigger ground axe blade which is from the Lapa das Boleiras site. (1) Diagonal slicing core on crystal quartz. (2) Opposite-platforms core on crystal quartz. (3) Retouched microliths on crystal quartz. (4) Ground axe blades on igneous rocks. Scale is the same for all artefacts in the figure. All drawings by the author.
Even though some lithic industries are finally being defined in technological terms in Eastern South America, many Paleoindian sites are known which have never been the target of systematic technological studies.
\nWe can mention the Paleoindian sites in the Amazon region. The Pedra Pintada cave, for example, presents
In the Serra da Canastra region, located between the Rioclarense and Lagoassantense coverage areas, some sites are known that present
The same must be said about the Paleoindian sites located in the middle Uruguay River, close to the Tigre/Catalanense/Pay Paso coverage areas. Even though some technological studies have been carried out in the Laranjito site [32], the technological analysis of the stemmed points in that region has never been done.
\nThe Lagoassantense and the Catalanense industries are proof that not all Paleoindian industries present
Paleoindian cultures in Eastern South America are finally starting to be studied more in detail due to the systematic research that has been carried out since the beginning of the twenty-first century. It is not yet possible to define archaeological cultures for the earlier Paleoindian period (before 13,000 cal BP) since those sites are rare in the whole American continent. But due the high presence of sites in the late Paleoindian period (after 13,000 cal BP), it is now possible to describe these cultures through systematic research of their lithic technologies. However, it is important to notice that much more research still needs to be carried out in order to have a more complete understanding.
\nArchaeological evidence in South America does not corroborate the “Clovis First” hypothesis—which assumes that the oldest evidence in Americas are the Clovis Culture artefacts—since many of these cultures arise simultaneously, or even previous to, the Clovis lithic industry [136], considering that the oldest associate Clovis sites date around 11,000 BP (13,000 cal BP) [137]. Few of the Eastern South American Paleoindian assemblages present technological features that are similar to Clovis, except maybe the Fell industry, which presents both blade technology and points made by the bifacial thinning method with fluting. In simple terms, Fell points are Clovis points with a retouched stem, and they are probably related, but it does not necessarily mean that Fell points are derived from Clovis [138]. No other artefact type in Eastern South America presents any similarities to Fell or Clovis points that could indicate any trace of cultural ancestry. In fact, it seems that several cultures emerged independently in South America, with particular, well-defined, attributes. The empirical data in South America is not feasible under the “Clovis First” hypothesis. Not surprisingly, new models are now being discussed, considering multiple migrations, the earliest ones before the Last Glacial Maximum [136].
\nMore research still needs to be done to better delimitate these industries in chronological and geographical terms and to enable verification of cultural ancestry relationships. Regarding the Itaparica tradition, even though recent studies cannot contradict the hypothesis that all sites are culturally homogeneous, few studies have actually been carried out, and the available data are not sufficient to verify if sites with
Lithic studies are important for the understanding of ancient societies, since lithics are the best-preserved class of material culture and many methods can be applied in their analysis. Lithics are the class of vestiges that most achieved results on understanding cultural diversity of the first human settlers in the Americas to this day. Other types of vestiges have not presented such potential either due to their preservation issues (the case of organic materials), lack of studies and data (e.g., bone artefacts), or even lack of potential to achieve cultural aspects (e.g., ancient DNA)—even though DNA brings us important data on the understanding of people’s biological dispersal, it does not tell us about cultural history of societies, like cultural origins and diversity, since genes and culture do not necessarily flow together. Studies of other archaeological materials related to the Eastern South American Paleoindian cultures are still necessary in order to understand them in a more complete and accurate way. Many of these sites present rock art, faunal remains, and micro residues that have never been studied until now. The bone industry is perhaps the category of material culture that most warrants detailed analysis in Eastern South America, since they also enable a technological analysis and are preserved in many Paleoindian sites in Eastern South America [121]. The more archaeologists become concerned with these issues, the more we can understand cultural diversity and the dispersal of the first human societies to colonise the South American continent during the Late Pleistocene. To understand this cultural diversity throughout time and space is the best way to understand the real history of native people, the ancestors of many of us.
\nI would like to thank the editors of the book for the invitation and opportunity to present the “state of the art” of Paleoindian research in Eastern South America. It is also necessary to mention that many of the Paleoindian cultures presented in the text are due to the research funding provided from 2015 to 2019 by the Coordination of Superior Level Staff Improvement (CAPES)—the main Brazilian government agency for scientific research funding.
\nAll dates were calibrated using the most appropriate curve for its location (IntCal 13 or SHCal13 calibration curves) [139], with 95.4% probability range.
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Cells encode “receptors” containing Ub-/Ubl-binding domains that interpret and translate each modification into appropriate cellular responses. Among the different Ubls, NEDD8, which is the ubiquitin’s closest relative, retains many of the structural determinants that enable ubiquitin the ability to target proteins to degradation. Nevertheless, the direct involvement of NEDD8 conjugation to proteasome recruitment has been proved only in a few cases. To date, well-defined major NEDD8 substrates are primarily members of the cullin family, and cullin neddylation does not appear to mark these proteins for degradation. Various studies have demonstrated that selectivity between ubiquitin and NEDD8 is guaranteed by small but substantial differences. Nevertheless, several issues still need to be addressed, mainly concerning which interaction surfaces mediate NEDD8 function and what domains recognize them. Recently, two novel domains identified in KHNYN and N4BP1 proteins have shed new light on this research area. Here, I discuss some recent reports that contributed to shed light on the mechanisms underlining the discrimination between ubiquitin and NEDD8. Understanding the details of these molecular mechanisms represents a prominent facet for the identification of new therapeutic targets.",book:{id:"8301",slug:"ubiquitin-proteasome-system-current-insights-into-mechanism-cellular-regulation-and-disease",title:"Ubiquitin Proteasome System",fullTitle:"Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease"},signatures:"Elena Santonico",authors:[{id:"271923",title:"Dr.",name:"Elena",middleName:null,surname:"Santonico",slug:"elena-santonico",fullName:"Elena Santonico"}]},{id:"28199",doi:"10.5772/31082",title:"F0F1 ATP Synthase: A Fascinating Challenge for Proteomics",slug:"f0f1-atp-synthase-a-fascinating-challenge-for-proteomics",totalDownloads:5529,totalCrossrefCites:2,totalDimensionsCites:8,abstract:null,book:{id:"780",slug:"proteomics-human-diseases-and-protein-functions",title:"Proteomics",fullTitle:"Proteomics - Human Diseases and Protein Functions"},signatures:"Federica Dabbeni-Sala, Amit Kumar Rai and Giovanna Lippe",authors:[{id:"85523",title:"Prof.",name:"Giovanna",middleName:null,surname:"Lippe",slug:"giovanna-lippe",fullName:"Giovanna Lippe"},{id:"149272",title:"Dr.",name:"Federica",middleName:null,surname:"Dabbeni-Sala",slug:"federica-dabbeni-sala",fullName:"Federica Dabbeni-Sala"},{id:"149273",title:"Dr.",name:"Amit",middleName:null,surname:"Kumar Rai",slug:"amit-kumar-rai",fullName:"Amit Kumar Rai"}]},{id:"65025",doi:"10.5772/intechopen.82883",title:"E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting",slug:"e3-ubiquitin-ligases-in-cancer-and-their-pharmacological-targeting",totalDownloads:1663,totalCrossrefCites:2,totalDimensionsCites:8,abstract:"Ubiquitination plays many critical roles in protein function and regulation. Consequently, mutation and aberrant expression of E3 ubiquitin ligases can drive cancer progression. Identifying key ligase-substrate relationships is crucial to understanding the molecular basis and pathways behind cancer and toward identifying novel targets for cancer therapeutics. Here, we review the importance of E3 ligases in the regulating the hallmarks of cancer, discuss some of the key and novel E3 ubiquitin ligases that drive tumor formation and angiogenesis, and review the clinical development of inhibitors that antagonize their function. We conclude with perspectives on the field and future directions toward understanding ubiquitination and cancer progression.",book:{id:"8301",slug:"ubiquitin-proteasome-system-current-insights-into-mechanism-cellular-regulation-and-disease",title:"Ubiquitin Proteasome System",fullTitle:"Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease"},signatures:"Joseph Y. Ong and Jorge Z. Torres",authors:[{id:"186645",title:"Dr.",name:"Jorge",middleName:null,surname:"Torres",slug:"jorge-torres",fullName:"Jorge Torres"},{id:"264944",title:"Mr.",name:"Joseph",middleName:null,surname:"Ong",slug:"joseph-ong",fullName:"Joseph Ong"}]},{id:"57410",doi:"10.5772/intechopen.71404",title:"The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview",slug:"the-cross-talk-among-autophagy-ubiquitination-and-dna-repair-an-overview",totalDownloads:1221,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"Cellular plasticity is modulated by protein posttranslational modifications, which act on most intracellular pathways. Ubiquitination is a versatile posttranslational modification (PTM) that influences protein fate, controlling their degradation or modulating their activity and subcellular localization. The ubiquitin proteasome system, UPS, and the autophagic pathway are the main degradative intracellular machineries, which rely on ubiquitination for their activation and/or the selective recycling of proteins and organelles. Recent findings indicate that the cross talk between UPS and autophagy plays a key role in controlling DNA repair pathways. Even being a cytoplasmic process, it is now clear that autophagy can directly impact on the correct activation of DNA repair. Of note, defects on autophagy are related to the impairment of homologous recombination repair and to an increase of the nonhomologous end joining repair activity. These evidences give new insights into the molecular processes underlying the DNA damage response and provide further explanation for the tumorigenesis associated with autophagy impairment. Moreover, these findings introduce new examples of synthetic lethality between autophagy and DNA repair genes and lead to the possible development of target therapies for tumors with defective autophagy.",book:{id:"5989",slug:"ubiquitination-governing-dna-repair-implications-in-health-and-disease",title:"Ubiquitination Governing DNA Repair",fullTitle:"Ubiquitination Governing DNA Repair - Implications in Health and Disease"},signatures:"Francesca Nazio, Emiliano Maiani and Francesco Cecconi",authors:[{id:"204392",title:"Prof.",name:"Francesco",middleName:null,surname:"Cecconi",slug:"francesco-cecconi",fullName:"Francesco Cecconi"},{id:"204393",title:"Dr.",name:"Emiliano",middleName:null,surname:"Maiani",slug:"emiliano-maiani",fullName:"Emiliano Maiani"},{id:"204394",title:"Dr.",name:"Francesca",middleName:null,surname:"Nazio",slug:"francesca-nazio",fullName:"Francesca Nazio"}]}],mostDownloadedChaptersLast30Days:[{id:"70577",title:"Proteoforms: General Concepts and Methodological Process for Identification",slug:"proteoforms-general-concepts-and-methodological-process-for-identification",totalDownloads:908,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The term proteoform is used to denote all the molecular forms in which the protein product of a single gene can be found. The most frequent processes that lead to transcript modification and the biological implications of these changes observed in the final protein product will be discussed. Proteoforms arising from genetic variations, alternatively spliced RNA transcripts and post-translational modifications will be commented. This chapter will present an evolution of the techniques used to identify the proteoforms and the importance of this identification for understanding of biological processes. This chapter highlights the fundamental concepts in the field of top-down mass spectrometry (TDMS), and provides numerous examples for the use of knowledge obtained from the identification of proteoforms. The identification of mutant proteins is one of the emerging areas of proteogenomics and has the potential to recognize novel disease biomarkers and may point to useful targets for identification of therapeutic approaches.",book:{id:"9352",slug:"proteoforms-concept-and-applications-in-medical-sciences",title:"Proteoforms",fullTitle:"Proteoforms - Concept and Applications in Medical Sciences"},signatures:"Jucélia da Silva Araújo and Olga Lima Tavares Machado",authors:[{id:"30130",title:"Dr.",name:"Olga Lima Tavares",middleName:null,surname:"Machado",slug:"olga-lima-tavares-machado",fullName:"Olga Lima Tavares Machado"},{id:"310148",title:"Dr.",name:"Jucelia",middleName:null,surname:"Da Silva Araujo",slug:"jucelia-da-silva-araujo",fullName:"Jucelia Da Silva Araujo"}]},{id:"65025",title:"E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting",slug:"e3-ubiquitin-ligases-in-cancer-and-their-pharmacological-targeting",totalDownloads:1665,totalCrossrefCites:2,totalDimensionsCites:8,abstract:"Ubiquitination plays many critical roles in protein function and regulation. Consequently, mutation and aberrant expression of E3 ubiquitin ligases can drive cancer progression. Identifying key ligase-substrate relationships is crucial to understanding the molecular basis and pathways behind cancer and toward identifying novel targets for cancer therapeutics. Here, we review the importance of E3 ligases in the regulating the hallmarks of cancer, discuss some of the key and novel E3 ubiquitin ligases that drive tumor formation and angiogenesis, and review the clinical development of inhibitors that antagonize their function. We conclude with perspectives on the field and future directions toward understanding ubiquitination and cancer progression.",book:{id:"8301",slug:"ubiquitin-proteasome-system-current-insights-into-mechanism-cellular-regulation-and-disease",title:"Ubiquitin Proteasome System",fullTitle:"Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease"},signatures:"Joseph Y. Ong and Jorge Z. Torres",authors:[{id:"186645",title:"Dr.",name:"Jorge",middleName:null,surname:"Torres",slug:"jorge-torres",fullName:"Jorge Torres"},{id:"264944",title:"Mr.",name:"Joseph",middleName:null,surname:"Ong",slug:"joseph-ong",fullName:"Joseph Ong"}]},{id:"65109",title:"Ubiquitin Signaling in Regulation of the Start of the Cell Cycle",slug:"ubiquitin-signaling-in-regulation-of-the-start-of-the-cell-cycle",totalDownloads:1560,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"The small protein ubiquitin plays a vital role in virtually all aspects of cellular life. Among the diverse signaling outcomes associated with ubiquitination, the most well-established is the targeted degradation of substrates via the proteasome. During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. In particular, ubiquitin-mediated degradation is critically important at transition points where it provides directionality and irreversibility to the cell cycle, which is essential for maintaining genome integrity. Specifically, the boundary between G1 and S-phase is tightly regulated by the ubiquitin proteasome system. Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation.",book:{id:"8301",slug:"ubiquitin-proteasome-system-current-insights-into-mechanism-cellular-regulation-and-disease",title:"Ubiquitin Proteasome System",fullTitle:"Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease"},signatures:"Michael James Emanuele and Taylor Paige Enrico",authors:[{id:"264977",title:"Dr.",name:"Michael",middleName:null,surname:"Emanuele",slug:"michael-emanuele",fullName:"Michael Emanuele"},{id:"282200",title:"Ms.",name:"Taylor",middleName:null,surname:"Enrico",slug:"taylor-enrico",fullName:"Taylor Enrico"}]},{id:"60432",title:"Protein-Based Detection Methods for Genetically Modified Crops",slug:"protein-based-detection-methods-for-genetically-modified-crops",totalDownloads:1403,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"The generation of genetically modified (GM) crops is rapidly expanding each and every year around the world. The well-being and quality assessment of these harvests are vital issues with respect to buyers’ interests. This drove the administrative specialists to execute an arrangement of extremely strict strategies for the endorsement to develop and use GMOs and to produce an interest in scientific techniques equipped for identifying GM crops. The GM crops have been added to the effective fuse of various attributes by presenting transgenes, for example, Bacillus thuringiensis (Bt) insecticidal qualities, in various crop species. GM crops give critical financial, natural, well-being and social advantages to both small and large agriculturists. The detection strategies incorporate either DNA-based or protein-based measures. Different immunoassays or catalyst connected immunosorbent tests are delicate and more affordable; however, they need experienced technicians. A very simple method, that is, immunochromatographic (ICS) test, is set up in the world, which is modest, compact and simple to utilize. The ICS is a semiquantitative method for indicative screening and semi-measurement of new remote proteins presented through hereditary change of plants. The strip is the easiest method for the assessment of several Bt crop plants for insecticidal quality.",book:{id:"6635",slug:"protein-protein-interaction-assays",title:"Protein-Protein Interaction Assays",fullTitle:"Protein-Protein Interaction Assays"},signatures:"Kausar Malik, Haleema Sadia and Muhammad Hamza Basit",authors:[{id:"238750",title:"Prof.",name:"Kausar",middleName:null,surname:"Malik",slug:"kausar-malik",fullName:"Kausar Malik"},{id:"243713",title:"Dr.",name:"Haleema",middleName:null,surname:"Sadia",slug:"haleema-sadia",fullName:"Haleema Sadia"},{id:"243714",title:"Mr.",name:"Muhammad Hamza",middleName:null,surname:"Basit",slug:"muhammad-hamza-basit",fullName:"Muhammad Hamza Basit"}]},{id:"60064",title:"Rapid Endosomal Recycling",slug:"rapid-endosomal-recycling",totalDownloads:1315,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Peripheral membrane proteins are endocytosed by constitutive processes of membrane invaginations, followed by internalization driven by diverse endocytic machinery available at the cell surface. It is believed that after endocytic uptake, cargo proteins proceed either through the endosomal recycling circuit of the cell or travel toward late endosomes for degradation. In this chapter, we analyzed trafficking of seven cargo molecules (transferrin receptor, fully conformed MHC-I, non-conformed MHC-I, cholera-toxin B subunit, CD44, ICAM1, and G-protein-coupled receptor Rae-1) known to use the distinct endocytic route. For that purpose, we developed the software for multicompartment analysis of intracellular trafficking. We demonstrate that all endocytosed molecules are rapidly recycled and propose that the rapid recycling is a constitutive process that should be considered in the analysis of intracellular trafficking of peripheral membrane proteins.",book:{id:"6649",slug:"peripheral-membrane-proteins",title:"Peripheral Membrane Proteins",fullTitle:"Peripheral Membrane Proteins"},signatures:"Hana Mahmutefendić, Gordana Blagojević Zagorac, Senka Maćešić\nand Pero Lučin",authors:[{id:"152008",title:"Prof.",name:"Pero",middleName:null,surname:"Lučin",slug:"pero-lucin",fullName:"Pero Lučin"},{id:"245873",title:"Prof.",name:"Hana",middleName:null,surname:"Mahmutefendić",slug:"hana-mahmutefendic",fullName:"Hana Mahmutefendić"},{id:"245875",title:"Prof.",name:"Gordana",middleName:null,surname:"Blagojević Zagorac",slug:"gordana-blagojevic-zagorac",fullName:"Gordana Blagojević Zagorac"},{id:"245876",title:"Prof.",name:"Senka",middleName:null,surname:"Maćešić",slug:"senka-macesic",fullName:"Senka Maćešić"}]}],onlineFirstChaptersFilter:{topicId:"913",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81188",title:"Structure- and Design-Based Difficulties in Recombinant Protein Purification in Bacterial Expression",slug:"structure-and-design-based-difficulties-in-recombinant-protein-purification-in-bacterial-expression",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.103958",abstract:"Protein purification is not a simple task. Yet, overexpression at bacterial systems with recombinant modifications brings further difficulties. Adding a tag, an affinity label, and expressing particular domains of the whole protein, especially hydrophobic sections, make purification a challenging process. Protein folding pattern may perturb N- or C-terminal tag and this terminal preference may lead to poor purification yield. Codon optimization, solvent content and type, ionic conditions, resin types, and self-cleavage of recombinant proteins bring further difficulties to protein expression and purification steps. The chapter overviews problems of protein purification through a small peptide overexpression in bacteria (Recombinant anti-SARS Coronavirus 2 (SARS-Cov-2) Spike protein Receptor Binding Domain (RBD) antibody (Clone Sb#14). The chapter also covers troubleshooting at distinct steps and highlights essential points to solve crucial issues of protein purification.",book:{id:"10839",title:"Protein Detection",coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg"},signatures:"Kubra Acikalin Coskun, Nazlıcan Yurekli, Elif Cansu Abay, Merve Tutar, Mervenur Al and Yusuf Tutar"},{id:"79353",title:"Protein Detection in Clinical Diagnosis and Management of Prevalent Neurodegenerative Diseases and Metabolic Disorders",slug:"protein-detection-in-clinical-diagnosis-and-management-of-prevalent-neurodegenerative-diseases-and-m",totalDownloads:88,totalDimensionsCites:0,doi:"10.5772/intechopen.101051",abstract:"An accurate diagnosis gives leeway to cost-effective treatments. However, many diseases continue to evolve; hence, their etiology is sometimes missed due to the procedures used during diagnosis. Protein-related diseases include proteopathies (proteinopathies) such as neurodegenerative diseases and metabolic disorders like protein-energy malnutrition and some hormonopathies. Hormonopathies are associated with the change in the production of hormones. Diabetes mellitus, a type of hormonopathy, is reviewed in this work alongside neurodegenerative diseases and protein-energy malnutrition. This chapter aims to elucidate more on the diagnosis of these diseases considering the structure and function of their proteins viz-a-viz their deficiencies and hyper-production in man. Their pathogenesis and the principles underlying their diagnosis are further discussed to optimize the management of these diseases among patients.",book:{id:"10839",title:"Protein Detection",coverURL:"https://cdn.intechopen.com/books/images_new/10839.jpg"},signatures:"Ohanube A.K. Goodluck, Obeta M. Uchejeso and Ikeagwulonu R. Chinaza"}],onlineFirstChaptersTotal:2},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 24th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:9,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. 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Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. 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He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. 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His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. 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She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"41",type:"subseries",title:"Water Science",keywords:"Water, Water resources, Freshwater, Hydrological processes, Utilization, Protection",scope:"