Mohammad Ahmad

By Nazneen Sultana, Juber Akhtar, Badruddeen, Mohammad Irfan Khan, Usama Ahmad, Muhammad Arif, Mohammad Ahmad and Tanmay Upadhyay

Nanoemulgel delivery system is a fusion of two different delivery systems, wherein the physical state of drug containing nanoemulsion is changed by adding it to the gel matrix, thus enabling more lipophilic drugs to be used in treatment therapies. It solves the major issues such as limiting use of lipophilic drugs, poor oral bioavailability, and unpredictable pharmacokinetic and absorption variations. Simultaneously, its nongreasy nature and easily spreading ability support the patient compliance. Nanoemulgel can be widely used in the treatment of acne, pimple, psoriasis, fungal infection, and inflammation cause by osteoarthritis and rheumatoid arthritis. The delivery of drug via ocular, vaginal, dental, and nose to brain routes for the treatment of diverse local and systemic ailments for instance alopecia, periodontitis, and Parkinson’s are possible. In the cosmetic industries, UV absorber nanoemulgel protected skin from sunburn.

Part of the book: Drug Development Life Cycle

By Rizwana Bee, Mohammad Ahmad and Kamal Kishore Maheshwari

According to the WHO report approximately 450 million people suffer from mental and behavioural disorder. Depression is one of the most common neurodegenerative disorders which arise due to the imbalance of neurotransmitters release at the synaptic cleft. A large number of synthetic drugs are being used as standard treatment for depression, they have many adverse effects that a limit the therapeutic treatment. Traditionally herbs are used for the treatment of depression which may offer advantage in terms of safety and tolerability, possibly by improvement in patient compliance. Herbal drugs are more commonly used because these have small amount of chemicals, these produced less side effects than standard drugs. Overall, this chapter presented an overview of the research that has been done on the many herbs, Mechanism of action involving monoamine reuptake, neuroreceptor binding and channel transporter function, and neural communication or HPA modulation. Several pharmaceutical companies are working on “triple” reuptake inhibitors that stop all three monoamines from being reabsorbed. Studies into the interplay of monoamine systems with other neurotransmitters (e.g., CRF, neurokinins, glutamate, and GABA etc.) will aid in the development of realistic, integrated neurochemical models of depression.

Part of the book: Medicinal Plants