Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
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We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\n
Throughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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In many areas of gastrointestinal surgery, new therapeutic and technical results have been accessible because of better connections with well-known pathological evolutions of diseases, more detailed diagnostic perspectives, and wide employment of mini-invasive and laparoscopic procedures.",isbn:"978-1-78923-605-7",printIsbn:"978-1-78923-604-0",pdfIsbn:"978-1-83881-424-3",doi:"10.5772/intechopen.69797",price:100,priceEur:109,priceUsd:129,slug:"gastrointestinal-surgery-new-technical-proposals",numberOfPages:100,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"f75fc66eb312d3a8a6be8256c5ffb279",bookSignature:"Vincenzo Neri",publishedDate:"September 5th 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6352.jpg",numberOfDownloads:5074,numberOfWosCitations:3,numberOfCrossrefCitations:1,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:5,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:9,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 12th 2017",dateEndSecondStepPublish:"July 3rd 2017",dateEndThirdStepPublish:"October 21st 2017",dateEndFourthStepPublish:"December 28th 2017",dateEndFifthStepPublish:"February 26th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"170938",title:"Prof.",name:"Vincenzo",middleName:null,surname:"Neri",slug:"vincenzo-neri",fullName:"Vincenzo Neri",profilePictureURL:"https://mts.intechopen.com/storage/users/170938/images/system/170938.jpeg",biography:"Vincenzo Neri is a former Professor of General Surgery (retired), Department of Medical and Surgical Sciences, University of Foggia, Italy. He also held positions such as Director of Division of General Surgery, Director of Residency School of General Surgery, Director of Department of Surgical Sciences, and President of Course of Degree of Medicine and Surgery at the same university. He also served as an assistant professor (1974–1982) and associate professor (1982–2001) at the School of Medicine and Surgery, University of Bari, Italy, where he obtained a degree in Medicine and Surgery and completed postgraduate training in General Surgery and Emergency Surgery. He obtained a diploma of 'Maitrise Universitaire en Pedagogie des Sciences de la Santè” from the University Paris-Nord Bobigny in 1995. Dr. Neri’s research interests include hepatobiliary pancreatic surgery, acute pancreatitis, and treatment of pancreatic and liver tumors. He has published research papers, reviews, congress proceedings, and book chapters. In the period 1991–2016, he attended the Hepatobiliarypancreatic Surgery Service of Beaujon Hospital, Universitè de Paris, Clichy. As part of the 2010–2011 ERASMUS Program, Dr. Neri developed a seminar on 'Cystic Tumours of the Pancreas” at Ghent University, Belgium. He is a member of several scientific associations including Società Italiana di Chirurgia (SIC), International Hepato-Pancreato Biliary Association (IHPBA), European Association for the Study of the Liver (EASL), New European Surgical Academy (NESA), and Society of Laparoscopic and Robotic Surgeons (SLS).",institutionString:"University of Foggia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"9",totalChapterViews:"0",totalEditedBooks:"5",institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1138",title:"Abdominal Surgery",slug:"abdominal-surgery"}],chapters:[{id:"59313",title:"Metabolic and Bariatric Surgery: Evolution, Techniques, and Management",doi:"10.5772/intechopen.73676",slug:"metabolic-and-bariatric-surgery-evolution-techniques-and-management",totalDownloads:1044,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Metabolic and bariatric surgery involves more than altering the stomach and small bowel anatomy to provoke structural changes in the gastrointestinal tract from a mechanical point of view to treat morbid obesity. Its profound impact on the body’s metabolism goes beyond anatomy and enters the realm of physiology. This is one of the most challenging and influential surgical subspecialties today due to its proven beneficial impact on the worldwide obesity epidemic and its millions of patients. A brief but comprehensive overview of the history of this fascinating yet challenging discipline and its advancement into the minimally invasive arena will be presented. Moreover, the body of this chapter will provide evidence-based data dealing with its indications, approaches, minimally invasive techniques including robotic surgery, the most common operations and the most recently introduced procedures, and management of complications. The impact of the laparoscopic revolution at the end of the twentieth century and the relevance of the robotic revolution from this century will be emphasized. 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Techniques used to re-establish the continuity of the digestive tract have been pectoral transposition flap, gastric pull-up, jejunum or colon transposition and free pedicled fascial-cutaneous flap reconstruction. Prosthetic reconstruction was thought of and used only as a temporary solution. In our clinic, we adapted the Montgomery oesophageal prosthesis as more than just a temporary solution and used it in 63 patients operated from 2004 to 2014 with advanced (stages III and IV) cancer involving most of the hypopharynx or extending towards the upper cervical oesophagus. Following total circular laryngo-pharyngectomy with bilateral modified radical neck dissection, prosthetic reconstruction was performed using the Montgomery oesophageal tube. Patients were followed up on, and their status was monitored. Favourable results encouraged the authors to further develop a new active prosthesis, with advanced design and materials that better mimic the anatomy and physiology of the replaced segment. Prosthetic reconstruction of the upper digestive tract following radical oncologic surgery is a viable option, with advantages compared to other laborious plastic techniques. The new active model is under development, hopefully offering soon a safe and more cost-effective alternative to the other techniques.",signatures:"Șerban V.G. Berteșteanu, Alexandru Nicolaescu, Bogdan Popescu\nand Raluca Grigore",downloadPdfUrl:"/chapter/pdf-download/59100",previewPdfUrl:"/chapter/pdf-preview/59100",authors:[{id:"216552",title:"Dr.",name:"Șerban V.G.",surname:"Berteșteanu",slug:"serban-v.g.-bertesteanu",fullName:"Șerban V.G. 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Cyst excision is the definitive treatment of choice for choledochal cyst because of the high morbidity and high risk of carcinoma after internal drainage, a commonly used treatment in the past. CDC is a congenital anomaly involving cystic dilatation of various ducts of biliary tree. The precise etiology of extrahepatic cysts continues to remain unclear. The most commonly accepted theory is an anomalous pancreatobiliary duct junction (APBDJ) and abnormal function of the sphincter of Oddi. Proper imaging plays an essential role in preoperative planning. Proper diagnosis evaluation and management is essential for optimal management. Type I cysts are the most frequently encountered. Choledochal cysts can have variable presentations. Hepatobiliary ultrasound and MRCP are the present day standards for imaging; early diagnosis should be the norm to avoid possible late complications of cholangitis, cirrhosis, hepaticolithiasis and spontaneous perforation. Excision of the cyst with hepaticojejunostomy is the best approach.",signatures:"Raashid Hamid, Nisar A. Bhat, Mansoor Ahmad and Balvinder Singh",downloadPdfUrl:"/chapter/pdf-download/60419",previewPdfUrl:"/chapter/pdf-preview/60419",authors:[{id:"213319",title:"Dr.",name:"Raashid",surname:"Hamid",slug:"raashid-hamid",fullName:"Raashid Hamid"},{id:"233782",title:"Dr.",name:"Nisar",surname:"Bhat",slug:"nisar-bhat",fullName:"Nisar Bhat"},{id:"233784",title:"Dr.",name:"Mansoor",surname:"Ahmad",slug:"mansoor-ahmad",fullName:"Mansoor Ahmad"},{id:"251293",title:"Dr.",name:"Balvinder",surname:"Singh",slug:"balvinder-singh",fullName:"Balvinder Singh"}],corrections:null},{id:"62058",title:"Diverticular Disease",doi:"10.5772/intechopen.78763",slug:"diverticular-disease",totalDownloads:970,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Diverticulosis is a common problem, especially in industrialized countries. The main risk factors for the development of diverticular disease are physical inactivity and consumption of a low-fiber diet. Among the population with diverticulosis, only 10–25% of the patients develop diverticulitis. Computed tomography (CT) scans are very helpful for diagnosis and deciding the treatment strategy. Patients with acute diverticulitis usually have a good response to conservative therapy. However, some of the patients present with complications such as perforation, fistula, abscess, stricture, and obstruction. Depending on disease severity, they commonly require surgical or radiologic intervention. Despite lots of contradictory results on treatment approaches, recent guidelines tend to be less invasive than the ones in the past. As a result, less invasive treatment protocols, including nonsurgical follow-up, percutaneous drainage, minimally invasive surgery and resection with primary anastomosis, are more commonly used than the more invasive Hartmann procedure. 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It rapidly increases during the preschool period and is important for early cognitive development, as it is a crucial component of executive functioning, self-regulation, and impulsivity. Inhibitory control training (ICT) is a novel intervention in which participants learn to associate appetitive cues with inhibition of behavior. It is being considered a promising approach in the treatment of psychopathology and appetitive behaviors. This book aims to bring together knowledge on the topic, considering research, clinic, and forensic field of intervention. 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\n
1. Introduction
\n
The secretions of the major and minor salivary glands, together with the gingival crevicular fluid, constitute whole saliva which provides the chemical milieu of the teeth and oral soft tissues [1]. Saliva formation can be evoked by sympathetic and parasympathetic stimulations [2]. The critical function of saliva is required for the preservation and maintenance of oral tissue [3]. Saliva is a complex secretion. About 93% by volume is secreted by the major salivary glands and the remaining 7% by the minor glands. About 99% of saliva is water and the other 1% is composed of organic and inorganic molecules [4]. Saliva consists of both full-length and partially degraded forms of mRNA, and its association with macromolecules may protect salivary RNA from degradation [5]. The proteome of the whole saliva will be relevant to oral health and be crucial for the identification of meaningful biomarkers for oral disease [6]. Sialometry and sialochemistry are used to diagnose systemic illnesses, monitoring general health, and as an indicator of risk for diseases creating a close relation between oral and systemic health [7]. Saliva acts as a mirror of the body’s health and could constitute the first line of defense against oxidative stress by controlling and/or modulating oxidative damages in the oral cavity [8].
\n
The analysis of salivary transcriptome may be beneficial effects in the detection of oral cancer and salivary diagnostics [9]. Cationic peptides and other defense proteins like lysozyme, bactericidal−/permeability-increasing protein (BPI), BPI-like proteins, PLUNC (palate lung and nasal epithelial clone) proteins, salivary amylase, cystatins, proline-rich proteins, mucins, peroxidases, and statherin are primarily responsible for innate immunity [10]. The protein and ion components make a solution that is 99% water into a viscoelastic solution capable of many roles, such as acting as a lubricant and an antimicrobial, preventing the dissolution of teeth, aiding digestion, and facilitating taste [11]. With the rapid advancement in salivaomics, saliva, as a noninvasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases [12]. Saliva has important functions in maintaining mucosal integrity and indigestion through salivary enzymes, buffering, remineralization, and lubrication [13].
\n
Saliva is an aqueous fluid found in the oral cavity playing a fundamental role in the preservation and maintenance of oral health [14]. Saliva acts in relation to taste, mastication, bolus formation, enzymatic digestion, and swallowing. The protective functions of saliva including maintenance of dental and mucosal integrity indirectly influence the digestive process [15]. The review aimed to discuss the different functions that are performed by the saliva.
\n
\n
1.1 Composition of saliva
\n
Saliva is composed of a variety of electrolytes, including sodium, potassium, calcium, magnesium, bicarbonate, and phosphates. Also found in saliva are immunoglobulins, proteins, enzymes, mucins, and nitrogenous products, such as urea and ammonia. These components interact in related functions in the following general area: (1) bicarbonates, phosphates, and urea act to modulate pH and the buffering capacity of saliva; (2) macromolecule proteins and mucins serve to cleanse, aggregate, and/or attach oral microorganisms and contribute to dental plaque metabolism; (3) calcium, phosphate, and proteins work together as an antisolubility factor and modulate demineralization and remineralization; and (4) immunoglobulins, proteins, and enzymes provide antibacterial action. The components listed above generally occur in small amounts, varying with changes in flow; however they continually provide an array of important functions. It is important to stress that saliva, as a unique biologic fluid, must be considered as a whole that is greater than the sum of its parts [3, 16].
\n
Saliva is a very dilute fluid, composed of more than 99% water. Saliva is not considered an ultrafiltrate of plasma [16, 17]; initially, saliva is isotonic; it is formed in the acini, but it becomes hypotonic when it travels through the duct network. The hypotonicity of unstimulated saliva allows the taste buds to perceive different tastes without being masked by normal plasma sodium levels. Hypotonicity, especially during low-flow periods, also allows for expansion and hydration of mucin glycoproteins, which protectively blanket tissues of the mouth [18]; lower levels of glucose, bicarbonate, and urea in unstimulated saliva augment the hypotonic environment to enhance taste.
\n
\n
\n
1.2 Organic and inorganic constituents of saliva
\n
The organic and inorganic compositions of saliva can supply information about alterations in enzymatic activity in response to periodontal inflammation [19]. Alkaline phosphatase (ALP) is a calcium-phosphate binding protein and a phosphor-hydrolytic enzyme. ALP is considered to be an important indicator of bone formation and is a phenotypic marker for osteoblast cells [20]. ALP was detected in the parotid, submandibular, and minor salivary glands, as well as in desquamated epithelial cells, leucocytes, and bacteria from dental plaque. The presence of the ALP in the saliva and in the gingival crevicular fluid is usually indicative of inflammation and/or destruction of the periodontal tissues. Among the several salivary components, urea is an organic compound that represents the final product of the human catabolism of proteins.
\n
The hydrolysis of urea by bacterial urease enzymes generates ammonia and CO2 and is considered a major pathway for alkali production in the oral cavity. In addition, ammonia is potentially cytotoxic for the periodontal tissues [21]. Ammonia can increase the permeability of the sulcular epithelium to other antigenic and toxic substances, thereby playing a fundamental role in the initiation of gingivitis [22]. The volume of saliva in the oral cavity depends on several factors, such as stimulation, circadian rhythm, diet, age, drugs, and the hydrogen (H+) ion concentration. Meanwhile, these factors can also be altered due to pathological conditions, such as periodontal disease [23] (Table 1).
\n
\n
\n
\n\n
\n
Salivary component
\n
Function
\n
\n\n\n
\n
Amylase
\n
Digestive
\n
\n
\n
Bicarbonate
\n
Buffering
\n
\n
\n
Calcium
\n
Remineralization
\n
\n
\n
Salivary antibodies
\n
Antimicrobial
\n
\n
\n
Lactoferrin
\n
Antimicrobial
\n
\n
\n
Lysozyme
\n
Hydrolysis of cell membrane
\n
\n
\n
Mucins
\n
Digestion, lubrication, and pellicle formation
\n
\n
\n
Protease
\n
Digestion
\n
\n
\n
Water
\n
Mucosal integrity
\n
\n\n
Table 1.
Components and functions of saliva.
\n
\n
\n
\n
2. Saliva functions
\n
\n
2.1 Immune functions
\n
The components like lysozyme, lactoferrin, salivary peroxidase, myeloperoxidase, and thiocyanate concentrations act as a defense mechanism in the whole saliva [24]. The natural defense properties of salivary secretions through clinical modalities such as the development of (1) diagnostic reagents and tests for local and systemic disease, (2) artificial salivas for the treatment of salivary dysfunction, and (3) topical vaccines to combat against oral diseases [25]. Salivary mucins are well recognized as an important factor in the preservation of the health of the oral cavity and are of significance to the processes occurring within the epithelial perimeter of mucosal defense [26]. Human saliva contains a number of physical, physicochemical, and chemical agents that protect oral tissues against noxious compounds. It effectively removes exogenous and endogenous microorganisms and their products into the gut and continuous presence of both nonimmune and immune factors in the mouth [27]. Salivary mucosal pellicle forms the structural basis of the local innate immune defense mechanism of the oral mucosa [28].
\n
\n
\n
2.2 Saliva proteome analysis
\n
The salivary flow rate influences to a high degree the rate of oral and salivary clearance of bacterial substrates included in foods and snacks [29]. Salivary IgA and lysozyme were inversely correlated with self-perceived work-related stress. As these salivary biomarkers are reflective of the mucosal immunity, results support the inverse relation between stress and mucosal immunity [30]. There was an inverse relationship between the presence of hyaluronidase and the presence of hyaluronidase inhibitors particularly in relation to intraoral wound healing and periodontal disease [31]. Human salivary α-amylase (HSA) is a major secretory protein component of saliva and has important biological functions, including the initial digestion of starch [32]. The collagen-cleaving enzyme matrix metalloproteinase-8 (MMP-8) is present in saliva and acts as measurable indicator of periodontal disease [33].
\n
Amylase present in human saliva was one of the first enzymes to be recognized and molecular mechanisms involved in amylolysis of starch and even of the physiological role of the salivary amylase itself [34]. Lactoferrin in saliva represents an important defense factor against bacterial injuries including those related to Streptococcus mutans and periodontopathic bacteria through its ability to decrease bacterial growth, biofilm development, iron overload, reactive oxygen formation, and inflammatory processes [35]. Some defense proteins, like salivary immune globulins and salivary chaperokine HSP70/HSPAs, are involved in both innate and acquired immunities [10]. Lactoferrin is a major component of biologically important mucosal fluids and is essential for mucosal-mediated immunity [36].
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The antimicrobial in vitro effects of the salivary proteins lactoferrin and lysozyme on microorganisms is involved in the carious process, obtaining their minimum inhibitory concentration and minimum bactericidal concentration [37]. Salivary alpha-amylase has been proposed as a sensitive noninvasive biomarker for stress-induced changes in the body that reflect the activity of the sympathetic nervous system [38]. Salivary α-amylase levels may therefore serve as an effective indicator in the noninvasive assessment of physical stress [39]. Lactoferrin is a multifunctional mammalian immunity protein that limits microbial growth through sequestration of nutrient iron [40]. Lysozyme in saliva is found to have the antibacterial activity against the pathogen, and there is potential for it to serve an antimicrobial role in the specific application of medical industry [41].
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Lactoferrin may be a useful agent to prevent irradiation effects in salivary glands [42]. LTF is examined as a first-line mediator in immune defense and response to pathogenic and nonpathogenic injuries as well as a molecule critical for control of oxidative cell function [43]. Salivary and pancreatic amylases hydrolyze starch and involvement of amylase in adiposity and starch metabolism [44]. Lactoferrin is a secretory protein with various physiological functions, and oral lactoferrin may mitigate psychological stress in humans [45].
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2.3 Role of lubrication
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The complex mix of salivary constituents provides an effective set of systems for lubricating and protecting the soft and hard tissues [46]. The lubricating and antimicrobial functions of saliva are maintained mainly by resting; saliva results in a flushing effect and the clearance of oral debris and noxious agents [47]. Saliva is a complex fluid, which influences oral health through specific and nonspecific physical and chemical properties [48]. Saliva contains numerous antimicrobial proteins that help protect the oral ecosystem from infectious agent [49]. Proteins can move from blood circulation into salivary glands through active transportation, passive diffusion, or ultrafiltration; some of which are then released into saliva and hence can potentially serve as biomarkers for diseases [50]. Saliva covers the oral hard and soft tissues with a conditioning film which governs the initial attachment of microorganisms, a crucial step in the setup of the oral microflora [51].
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2.4 Role of digestion
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A high quality of saliva is an essential factor to protect the dental elements against attrition and promote the digestion process [52]. Saliva is the principal fluid component of the external environment of the taste receptor cells which is involved in the transport of taste substances and protection of the taste receptor [53]. The role of human saliva and its compositional elements in relation to the GI functions of taste, mastication, bolus formation, enzymatic digestion, and swallowing [54]. Salivary nonesterified fatty acids (NEFA) are proposed to play a role in oral health and oral fat detection, and they may hold diagnostic and prognostic potential [55].
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Lingual lipase generates nonesterified fatty acids (NEFA) from dietary fats during oral processing by lipolysis. Lingual lipase in rodents has strong lipolytic activity and plays a critical role in oral detection of fats [56]. Physiological role of salivary lipolytic activity in the regulation of the basal FFA concentration could be involved in fat taste sensitivity [57]. During chewing, saliva helps in preparing the food bolus by agglomerating the formed particles, and it initiates enzymatic food breakdown [58]. Saliva plays a key role in the eating process and on the perception of flavor. Flavor corresponds to the combined effect of taste sensations, aromatics, and chemical feeling factors evoked by food in the oral cavity [59].
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2.5 Role of diagnostic properties
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Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use [61]. Fluid addition facilitated chewing of dry foods and feeding disorders caused by hyposalivation [62]. Saliva has been demonstrated to be a promising bodily fluid for early detection of diseases, and salivary diagnostics have exhibited tremendous potential in clinical applications [63]. Saliva has the potential to become a first-line diagnostic sample of choice owing to the advancements in detection technologies coupled with combinations of biomolecules with clinical relevance [64]. Saliva is a useful diagnostic fluid for oral-related diseases. Monitoring salivary biomarkers for oral and systemic diseases could become an important complement to clinical examinations in epidemiological surveys [65] (Figure 1).
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Figure 1.
Different functions of the saliva [60].
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The high rate of changes in the composition of saliva can be used for the monitoring of various biorhythms in order to study the physiological characteristics of the human body [66]. The significant influences of the oral environment observed in this study increase the current understanding of the salivary microbiome in caries. These results will be useful for expanding research directions and for improving disease diagnosis, prognosis, and therapy [67].
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2.6 Role of maintenance of health teeth
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The role of saliva, the prevalence of oral dryness and the consequent importance of salivary flow as well as the relationship between xerostomia and salivary gland hypofunction amongst the causes of oral dryness [68]. Saliva is the medium that bathes the taste receptors in the oral cavity and in which aroma and taste compounds are released when food is eaten. Moreover saliva contains enzymes and molecules that can interact with food [69]. Saliva is an important fluid in the oral cavity as it bathes the teeth and the soft tissues. The salivary pH, buffer capacity and mineral content of calcium (Ca), phosphate (P), sodium (Na), and potassium (K) are important in the tooth de−/remineralization process and calculus formation [70]. Significant change in the pH depends on the severity of the periodontal condition. The salivary pH shows significant changes and thus relevance to the severity of periodontal disease. Salivary pH may thus be used as a quick chairside diagnostic biomarker [71]. Taste perception elicited by food constituents and facilitated by sensory cells in the oral cavity is important for the survival of organisms. In addition to the five basic taste modalities, sweet, umami, bitter, sour, and salty, orosensory perception of stimuli such as fat constituents is intensely investigated [72].
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Teeth are exposed to food, drinks, and the microbiota of the mouth and have a high resistance to localized demineralization that is unmatched by bone [73]. The pH of saliva and plaque will result in white spot lesions on the tooth surface which are considered initialization of caries because of demineralization [74]. Saliva is an important biological fluid that aids in mechanically removing food debris and bacteria from the oral cavity and teeth; reduced salivary flow causes ill effects to the oral tissues [13].
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2.7 Antimicrobial, antiviral, and antifungal functions
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A group of salivary proteins like lysozyme, lactoferrin, and lactoperoxidase working in conjunction with other components of saliva can have an immediate effect on oral bacteria, interfering with their ability to multiply or killing them directly. Lysozyme can cause lysis of bacterial cells, especially Streptococcus mutans, by interacting with anions of low charge density chaotropic ions (thiocyanate, perchlorate, iodide, bromide, nitrate, chloride, and fluoride) and with bicarbonate. It has recently been shown that another cationic peptide in saliva the histidine-rich peptide of parotid saliva has growth-inhibitory and bactericidal effects on oral bacteria. The histidine-rich peptides appear to be an effective antifungal agent as well, able to inhibit growth and kill Candida albicans at a very low concentration [75].
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Lactoferrin, the exocrine gland equivalent of transferrin, is effective against bacteria that require iron for their metabolic processes. It can compete with the bacterial iron-chelating molecules and deprive the bacteria of this essential element. Lactoferrin is also capable of a bactericidal effect that is distinct from simple iron deprivation. Salivary peroxidase is part of an antibacterial system which involves the oxidation of salivary thiocyanate by hydrogen peroxide (generated by oral bacteria) to hypothiocyanite and hypothiocyanous acids. These products, in turn, affect bacterial metabolism (especially acid production) by oxidizing the sulfhydryl groups of the enzymes involved in glycolysis and sugar transport. The antimicrobial effect of salivary peroxidase against S. mutans is significantly enhanced by interaction with secretory IgA.
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The protective potential of all the antibacterial proteins can be extended by interaction with mucin which can serve to concentrate this defense force at the interface of the mucosa and the inhospitable external environment. When teeth are present, especially if some gingivitis exists, the oral fluids will be augmented by a contribution from the gingival crevice area, the gingival crevicular fluid. This fluid can contribute to the oral defense system by providing (a) serum antibodies against oral bacteria, especially IgG antibodies, (b) phagocytic cells (PMNs), and (c) antibacterial products liberated from the phagocytic cells, e.g., lysozyme, lactoferrin, and myeloperoxidase [27].
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The large number of antibacterial and antiviral proteins is present in human saliva. Of interest, most of these antibacterial proteins display antiviral activity, typically against specific viral pathogens. The review focuses on one protein that interacts with both bacteria and viruses, gp340, originally referred to as salivary agglutinin. In the oral cavity, soluble gp340 binds to and aggregates a variety of bacteria, and this is thought to increase bacterial clearance from the mouth. However, when bound to the tooth surface, gp340 promotes bacterial adherence. In the oral cavity, most gp340 proteins are found soluble in saliva and can function as a specific inhibitor of infectivity of HIV-1 and influenza A. In contrast, in the female reproductive track, most gp340 proteins are bound to the cell surface, where it can promote HIV-1 infection [76].
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The saliva anti-fungal activity against Candida albicans and Cryptococcus neoformans. Therefore, the importance of the search for new, broad-spectrum anti-fungals with little or no toxicity cannot be overemphasized. The following properties make histatins promising antifungal therapeutic agents: (1) they have little or no toxicity, (2) they possess high cidal activities against azole-resistant fungal species and most of the fungal species tested, and (3) their candidacidal activity is similar to that of azole-based antifungals. Current research efforts focus on the development of improved histatins with enhanced cidal activity and stability and of suitable and effective histatin delivery systems. These and other approaches may help to outpace the growing list of drug-resistant and opportunistic fungi causing life-threatening, disseminating diseases. The histatins with improved protective properties may also be used as components of artificial saliva for patients with salivary dysfunction [77].
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3. Conclusions
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Saliva is secreted by salivary glands and has multiple proteins and enzymes. The saliva flow rate and pH are very important for maintenance of oral tissues. The protective role and benefits including buffering, remineralization in the healthy oral mucosa, immune defense, digestion, lubrication, diagnostic purpose, and proteome analysis are fulfilled by saliva. Saliva aids in maintaining mucosal integrity and in digestion through salivary enzymes. Saliva is essential information of the pellicle, which protects the tooth after eruption. Normal salivary composition, flow, and function are extremely important on a daily basis. It occurs in quantities, large or small, and recognition should be given to the many contributions it makes to the preservation and maintenance of health.
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Conflict of interest
The authors report no declarations of interest.
\n',keywords:"functions of saliva, role of lubrication, antimicrobial functions of saliva",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/66233.pdf",chapterXML:"https://mts.intechopen.com/source/xml/66233.xml",downloadPdfUrl:"/chapter/pdf-download/66233",previewPdfUrl:"/chapter/pdf-preview/66233",totalDownloads:2006,totalViews:0,totalCrossrefCites:2,totalDimensionsCites:3,totalAltmetricsMentions:0,impactScore:2,impactScorePercentile:79,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"October 11th 2018",dateReviewed:"January 24th 2019",datePrePublished:null,datePublished:"October 23rd 2019",dateFinished:"March 20th 2019",readingETA:"0",abstract:"Saliva is produced and secreted by salivary glands. The basic secretary units of salivary glands are clusters of acini cells. It is fluid that contains water, electrolytes, mucus, and enzymes, all of which flow out of the acinus into collecting ducts, certainly one of the most important components and an integral component to oral health. The protective role and benefits including buffering, remineralization in the healthy oral mucosa, immune defense, digestion, lubrication, diagnostic purpose, and proteome analysis are fulfilled by saliva. It aids in maintaining mucosal integrity and indigestion through salivary enzymes. The functions of saliva in maintaining oral health and the main factors that cause alterations in salivary secretion and the importance of saliva in caries development and bacterial plaque formation are discussed, and also its role and functions and organic and inorganic constituents in saliva are discussed. This is of great importance in ruminants, which have non-secretory forestomachs. Diseases of the salivary glands and ducts are not uncommon in animals and man, and excessive salivation is a symptom of almost any lesions in the oral cavity.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/66233",risUrl:"/chapter/ris/66233",book:{id:"7905",slug:"saliva-and-salivary-diagnostics"},signatures:"Narendra Maddu",authors:[{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",fullName:"Narendra Maddu",slug:"narendra-maddu",email:"dr.narendramaddu@gmail.com",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Composition of saliva",level:"2"},{id:"sec_2_2",title:"1.2 Organic and inorganic constituents of saliva",level:"2"},{id:"sec_4",title:"2. Saliva functions",level:"1"},{id:"sec_4_2",title:"2.1 Immune functions",level:"2"},{id:"sec_5_2",title:"2.2 Saliva proteome analysis",level:"2"},{id:"sec_6_2",title:"2.3 Role of lubrication",level:"2"},{id:"sec_7_2",title:"2.4 Role of digestion",level:"2"},{id:"sec_8_2",title:"2.5 Role of diagnostic properties",level:"2"},{id:"sec_9_2",title:"2.6 Role of maintenance of health teeth",level:"2"},{id:"sec_10_2",title:"2.7 Antimicrobial, antiviral, and antifungal functions",level:"2"},{id:"sec_12",title:"3. Conclusions",level:"1"},{id:"sec_16",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Edgar WM. Saliva: Its secretion, composition and functions. British Dental Journal. 1992;172(8):305-312\n'},{id:"B2",body:'Melvin JE. Chloride channels and salivary gland function. Critical Reviews in Oral Biology and Medicine. 1999;10(2):199-209\n'},{id:"B3",body:'Humphrey SP, Williamson RT. A review of saliva: Normal composition, flow, and function. 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Mutans streptococci, Lactobacilli in saliva and acidity for microorganisms in dental plaque: Changes after restorative treatment. The Journal of Indian Society of Periodontology. 2004;28:327-332\n'},{id:"B76",body:'Malamud D, Abrams WR, Barber CA, Weissman D, Rehtanz M, Golub E. Antiviral activities in human saliva. Advances in Dental Research. 2011;23:34-37\n'},{id:"B77",body:'Tsai H, Bobek LA. Human salivary histatins: Promising anti-fungal therapeutic agents. Critical Reviews in Oral Biology and Medicine. 1998;9:480-497\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Narendra Maddu",address:"dr.narendramaddu@gmail.com",affiliation:'
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1. Introduction
Elastography was introduced to clinical practice almost two decades back, to further enhance ultrasound imaging [1] and illustrate the difference in mechanical properties between diseased and healthy tissue [2], i.e., difference in tissue stiffness, in a qualitative and quantitative way. The basic idea of elastography is to take advantage of the changed tissue elasticity/stiffness during tissue disease as compared to adjacent similar normal tissues.
The advantages of ultrasound (U/S)—in general—is being a rapid bed-side test, low cost, availability, and great patient compliance all of which elastography makes use of.
Elastography imaging for liver fibrosis assessment is a well-known technique; yet recent territories for tissue elasticity assessment are emerging. One of these large territories is muscle tendons elasticity assessment in different pathologic conditions. One of these areas is changes in tendons stiffness.
In the nineteenth century, Fritz De Quervain reported patients with pain and swelling at the wrist. It is an entrapment condition (tendon inflammation) of the tendons within the first extensor (dorsal) compartment of the wrist back of the wrist; patients suffered pain during motion of the thumb. The tenosynovitis affects the abductor pollicis longus (APL) and the extensor pollicis brevis (EPB) tendons-muscle tendons at the back of the wrist [3].
Anatomically, the first extensor compartment of wrist joint is lying between the radial styloid process and the base of the thumb, containing two muscle tendons: the abductor pollicis longus (APL).
De Quervain disease is considered the second most common tendon entrapment condition after trigger finger. Because of repeated trauma, the first dorsal extensor compartment tendons thicken, hindering their gliding through the tight fibro-osseous tunnel.
In B-mode ultrasound scan of the first dorsal compartment, we can find one or more of the following criteria: fluid collection, thickening of tissues, or tissue edema. Colored Doppler application to the tissue under investigation shows increased blood flow to the area.
2. Elastography techniques
Tissue elasticity is assessed with ultrasound tissue elastography. Elasticity of a tissue is its tendency to resist deformation when applying force the tissue in question, or regaining its original shape after cessation of the force. The idea of elastography is based on assuming that the tissue under examination is entirely elastic and has no viscosity [4].
Two main techniques are developed to measure tissue elasticity quantitatively using ultrasound machines:
Strain technique: apply normal stress to the tissue and the normal strain of the tissue is calculated; where tissue strain is its ability to expand after removal of the stress [4].
Shear-wave technique: a dynamic stress applied to the tissue under examination using different techniques to apply such a dynamic stress, and the tissue strain is calculated [4].
3. Strain technique
Strain technique is first to evolve between the two techniques mentioned above, and it uses two methods for strain calculation: either strain elastography or acoustic radiation force impulse (ARFI). What we are concerned here is about the first method, i.e., strain elastography.
Strain elastography can be achieved by two methods of excitation:
Manual compression by the operator using the ultrasound transducer; provided that the examined tissue is superficial.
No manual compression; where tissue displacement occur physiologically with internal organs as cardiovascular or respiratory systems, hence deeper structures could be studied.
What we are concerned with here is manual compression that is explained in details later on.
4. Tsukuba score for tissue elasticity
Tsukuba elasticity score is a 1–5 score scale; built upon a map of stiffness of tissues in and around the pathologically affected segment, and the score calculated based upon the stiffness of the lesion in relation to the surrounding tissues.
Lesions scored (1): lesion has less or equal stiffness to surrounding tissues;
Lesions scored (2): lesion has mixed areas of stiffness;
Lesions scored (3): lesion is stiffer than surrounding tissue, and on elastogram has lesser size than B-mode ultrasound;
Lesions scored (4): lesion is stiffer than the surrounding tissue, and on elastogram has same size as B-mode ultrasound; and
Lesions scored (5): lesion is stiffer than the surrounding tissue, and larger on elastogram than B-mode ultrasound.
5. Study goal
My hypothesis was that with the pathological changes in the first extensor compartment tendons of the wrist by virtue of the disease, we could use the Tsukuba score for tissue elasticity [5] to quantitatively assess the elasticity or hardness of the affected tendons.
6. Ultrasound and strain-based elastography examination technique
Ultrasound examinations performed using Philips IU22 xMatrix machine (Philips Ultrasound, Bothell, WA, USA) with linear transducer (12–15 MHz). Advanced small parts option and elastography QLAB were used.
The patient positioned in sitting at the edge of the examination couch with legs dependent, i.e., both knees flexed at right angle with forearm under examination positioned over the ipsilateral thigh in pronation with a clean plastic sheet in between the thigh and forearm of the patient.
B-mode ultrasound examination of the compartment retinaculum and tendons performed at the start to scrutinize the full spectrum of the lesion in transverse and longitudinal views.
Strain-based elastography was then performed by applying controlled pressure over the compartment guided by colored column on screen of ultrasound machine to achieve the proper pressure amount for strain-based elastography calculation by the machine.
Strain-based elastography mean and standard deviation calculations readings are then displayed.
Three strain-based elastography readings are taken for the patient and averaged to calculate the final reading, which will be used to diagnose the condition.
7. The problem
The condition is an entrapment syndrome.
8. Anatomy
The first extensor compartment of wrist joint is lying between the radial styloid process and the base of the thumb, containing two muscle tendons: the abductor pollicis longus (APL), which is inserted into the base of the first metacarpal bone, or into trapezium bone and extensor pollicis brevis (EPB), which is inserted into the proximal phalanx of the thumb [6].
The APL and EPB muscle tendons with their synovial sheets travel under the extensor retinaculum, which are attached to radial styloid forming tight fibro-osseous tunnel.
9. Epidemiology
De Quervain tenosynovitis is considered the second most common tendon entrapment condition after stenosing tenosynovitis-trigger finger [7].
The condition occurs in middle-aged persons with 3:1 female to male ratio [7].
The condition occurs by the virtue of repetitive wrist movement associated with thumb radial abduction with wrist extension and radial wrist deviation [8].
The classic populations are mothers and childcare workers; however, secretaries and nurses much presented [7, 8]. Other populations affected are golf players or frequent hammer users [9, 10].
Modern life style escalated the incidence of De Quervain tenosynovitis because of computer and cellular phones excessive use [11].
10. Clinical presentation
Main patient complaint is pain and swelling over the styloid process of the radius [12].
On examination, swelling and tenderness over radial styloid found. Crepitus and triggering may be also found [12].
Finkelstein’s test, the clinical test examination, involves flexion of the metacarpophalangeal joint of the thumb in a closed hand followed by ulnar deviation passively of the wrist joint can replicate the pain at radial styloid [9, 12].
11. Pathology
Because of repeated trauma, the APL and EPB tendons thicken, hindering their gliding through the tight fibro-osseous tunnel [13, 14].
Pathologically, the tendons are thickened by virtue of degenerative changes such as myxoid degeneration, deposition of mucopolysaccharides, and fibrocartilagenous metaplasia [13, 14].
Hence, it is a misnomer to call the condition tenosynovitis, as the pathological changes do not involve tendons inflammation [15].
12. B-mode ultrasound findings
Several findings could be detected in B-mode ultrasound scan of the first dorsal compartment prior to strain-based elastography application; these findings include [16]:
Fluid collection in the tendon sheaths (Figure 1).
Thick edematous tendons of APL and EPB (Figure 3) at level of styloid process of the radius (compared with contralateral side).
Halo sign; due to edema in the tissues surrounding the tendons.
Doppler application reveals hyperemia surrounding the tendons.
Figure 1.
Fluid collection in the synovial sheaths of APL and EPB muscle tendons in transverse ultrasound image of a patient with De Quervain tenosynovitis.
Figure 2.
Thickened synovial sheaths of APL and EPB muscle tendons with fluid collection in tendon sheath in transverse ultrasound image of a patient with De Quervain tenosynovitis.
Figure 3.
Thick edematous tendon of APL muscle in longitudinal ultrasound image of a patient with De Quervain tenosynovitis.
13. Current study
Fifty-two subjects were studied; 30 diseased comprised group 1 and 22 healthy comprised group 2.
The main complaint of the diseased group was pain at the radial side of the wrist with positive Finkelstein test, while healthy subjects were symptom-free with negative Finkelstein test.
There was no significant difference (p > 0.01) between groups in regards to age and sex.
Strain-based elastography indices are illustrated in Table 1.
Index
Percentage (%)
PPV
95
NPV
90
Sensitivity
92
Specificity
93
Table 1.
Strain-based elastography indices.
The mean elastography value for the diseased was 2.3; while for healthy subjects, it was 6.1 with statistically significant difference between the two groups (p < 0.001). For strain ratio details, refer to Table 2.
Number of subjects
Strain-based elastography ratio
28 patients
1–3.5
2 patients
4.2–6
20 volunteers
6.1–9.2
2 volunteers
2–3.9
Table 2.
Strain-based elastography ratios in De Quervain tenosynovitis patients and volunteers.
The threshold for diagnosing De Quervain disease was 4.
B-mode ultrasound findings displayed in Table 2 [3].
14. Discussion
In De Quervain tendinopathy tendon increased cross section, increased water content of the tendons, abnormal degenerative materials deposited, and changes in collagen fibers properties all lead to changes of the elastic characteristics of the tendons with consequent softening of the affected tendons [17].
In my work, I found lower sensitivity (92%) than specificity (93%) for the quantitative assessment of the disease, in accordance with the remarks of Sébastien Aubry studying the Achilles tendinopathy with shear-wave elastography [18].
De Zordo et al. [19] stated that normal Achilles tendons show hard consistency as compared to diseased tendons, going with my work results of 6.1 elastography mean value for healthy subjects and 2.3 for diseased. Moreover, Dirrichs et al. [20] studied epicondylar, Achilles, and prepatellar pathologic tendons and found that the diseased tendons returned decreased elastography values as compared to healthy volunteers regardless of anatomical location.
In my study, I found statistically significant difference (p < 0.001) between healthy and diseased subjects in regards to elastography readings in accordance with Chen and coworkers concluding that elastography is an important tool for mechanical information assessment of Achilles function [21].
In two healthy subjects, we found low strain ratio, which could be explained by the fact that they were having subclinical tenosynovitis as postulated by De Zordo et al. [22].
Moreover, not possibly to explain the three diseased tendons showing high elastography values except for one patient with cyst formation under the retinaculum raising the tension inside the compartment.
More study is needed for the true benefit of strain-based elastography of the condition comparing the results with histopathological specimens—if possible—of the affected tendons, for a definitive proof of the presence or absence of the disease and the state of progression of the disease.
15. Conclusion
We can conclude that the disease can be diagnosed with strain-based elastography in a quantitative way with confidence and reliability.
Conflict of interest
The author declares no conflict of interest financially or personally with any institution, organization, or persons.
\n',keywords:"ultrasound, elastography, strain-based elastography, strain elastography, wrist joint, De Quervain tenosynovitis",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/70118.pdf",chapterXML:"https://mts.intechopen.com/source/xml/70118.xml",downloadPdfUrl:"/chapter/pdf-download/70118",previewPdfUrl:"/chapter/pdf-preview/70118",totalDownloads:792,totalViews:0,totalCrossrefCites:0,dateSubmitted:"February 14th 2019",dateReviewed:"July 5th 2019",datePrePublished:"November 20th 2019",datePublished:"March 4th 2020",dateFinished:"November 20th 2019",readingETA:"0",abstract:"Elastography was introduced to clinical practice almost two decades back, to further enhance ultrasound imaging for illustrating the difference in mechanical properties between diseased and healthy tissues, i.e., difference in tissue stiffness, in a qualitative and quantitative way. In the nineteenth century, Fritz De Quervain reported patients with pain and swelling at the wrist. It is an entrapment condition of the tendons within the first extensor compartment. The advantages of ultrasound (U/S), in general, is being a rapid bed-side test, low cost, availability, and great patient compliance all of which elastography makes use of. Elastography imaging for liver fibrosis assessment is a well-known technique; yet recent territories for tissue elasticity assessment are emerging. One of these large territories is muscle tendons elasticity assessment in different pathologic conditions. One of these areas is changes in tendons stiffness. Fifty-two subjects were studied, 30 diseased and 22 healthy. The main complaint of the diseased group was pain at the radial side of the wrist, while healthy subjects were symptom free. Sensitivity was 92%, while specificity was 93%. From my work, I reached the conclusion of that the disease can be diagnosed with strain-based elastography in a quantitative way with confidence and reliability.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/70118",risUrl:"/chapter/ris/70118",signatures:"Ahmad Mohammad Ghandour",book:{id:"8691",type:"book",title:"Ultrasound Elastography",subtitle:null,fullTitle:"Ultrasound Elastography",slug:"ultrasound-elastography",publishedDate:"March 4th 2020",bookSignature:"Monica Lupsor-Platon",coverURL:"https://cdn.intechopen.com/books/images_new/8691.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78985-710-8",printIsbn:"978-1-78985-709-2",pdfIsbn:"978-1-83880-015-4",isAvailableForWebshopOrdering:!0,editors:[{id:"208594",title:"Associate Prof.",name:"Monica",middleName:null,surname:"Lupsor-Platon",slug:"monica-lupsor-platon",fullName:"Monica Lupsor-Platon"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Elastography techniques",level:"1"},{id:"sec_3",title:"3. Strain technique",level:"1"},{id:"sec_4",title:"4. Tsukuba score for tissue elasticity",level:"1"},{id:"sec_5",title:"5. Study goal",level:"1"},{id:"sec_6",title:"6. Ultrasound and strain-based elastography examination technique",level:"1"},{id:"sec_7",title:"7. The problem",level:"1"},{id:"sec_8",title:"8. Anatomy",level:"1"},{id:"sec_9",title:"9. Epidemiology",level:"1"},{id:"sec_10",title:"10. Clinical presentation",level:"1"},{id:"sec_11",title:"11. Pathology",level:"1"},{id:"sec_12",title:"12. B-mode ultrasound findings",level:"1"},{id:"sec_13",title:"13. Current study",level:"1"},{id:"sec_14",title:"14. Discussion",level:"1"},{id:"sec_15",title:"15. Conclusion",level:"1"},{id:"sec_19",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Prker KJ, Huang SR, Musulin RA, Lerner RM. Tissue-response to mechanical vibrations for sonoelasticity imaging. Ultrasound in Medicine & Biology. 1990;16:241-246'},{id:"B2",body:'Doyley MM, Parker KJ. Elastography: General principles and clinical applications. Ultrasound Clinics. 2014;9(1):1-11. DOI: 10.1016/j.cult.2013.09.006'},{id:"B3",body:'Ghandour AM, Ghandour TM. Strain-based elastography assessment of patients with De Quervain tenosynovitis: A preliminary study. The Egyptian Journal of Radiology and Nuclear Medicine. 2018;49:415-418'},{id:"B4",body:'Sigrist RMS, Liau J, El Kaffas A, Chammas MC, Willmann JK. Ultrasound elastography: Review of techniques and clinical applications. Theranostics. 2017;7(5):1303-1329. DOI: 10.7150/thno.18650'},{id:"B5",body:'Itoh A, Ueno E, Tohno E, Kamma H, Takahashi H, Shiina T, et al. Breast disease: Clinical application of US elastography for diagnosis. Radiology. 2006;239:341-350'},{id:"B6",body:'Hazani R, Engineer NJ, Cooney D, Wilhelmi BJ. Anatomic landmarks for the first dorsal compartment. Eplasty. 2009;8:6-11'},{id:"B7",body:'Zanzoni A. Mint: A molecular interaction database. Journal of Microbiology. 2002;513:135-140. DOI: 10.1016/s0014-5793(01)03293-8'},{id:"B8",body:'Satteson E, Shruti C. Tannan: De Quervain tenosynovitis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2019'},{id:"B9",body:'Ritu G, Abzug Joshua M. De Quervain’s tenosynovitis: A review of the rehabilitative options. Hand (N Y). 2015;10(1):1-5'},{id:"B10",body:'Jaworski CA, Krause M, Brown J. Rehabilitation of the wrist and hand following sports injury. Clinics in Sports Medicine. 2010;29(1):61-80. DOI: 10.1016/j.csm. 2009.09.007'},{id:"B11",body:'Ali M, Asim M, Danish SH, et al. Frequency of De Quervain’s tenosynovitis and its association with SMS texting. Muscles Ligaments Tendons Journal. 2014;4(1):74'},{id:"B12",body:'Stoller DW, Tirman PF, Bredella MA. Diagnostic imaging, Orthopaedics. Amirsys Inc; 2004. ISBN: 0721629202'},{id:"B13",body:'Cyriac P-V, van der Windt DAWM, Winters Jan C, Betty M-d J, Cochrane Musculoskeletal Group. Corticosteroid injection for de Quervain’s tenosynovitis. Cochrane Database of Systematic Review; 2009. DOI: 10.1002/14651858. CD005616.pub2'},{id:"B14",body:'Min CJ, Jae-Kyung W, Kyoung-Bun L, In Ae P, Ann Y, Kyung MW. Comparison of shear-wave and strain ultrasound elastography in the differentiation of benign and malignant breast lesions. AJR. 2013;201:W347-W356'},{id:"B15",body:'Clarke MT, Lyall HA, Grant JW, Matthewson MH. The histopathology of de Quervain’s disease. Journal of Hand Surgery (British). 1998;23(6):732-734'},{id:"B16",body:'Diop AN, Ba-Diop S, Sane JC, et al. Role of US in the management of de Quervain’s tenosynovitis: Review of 22 cases. Journal de Radiologie. 2008;89(9 Pt 1):1081-1084'},{id:"B17",body:'Cortes Daniel H, Suydam Stephen M, Grävare SK, Buchanan Thomas S, Elliott Dawn M. Continuous shear wave elastography: A new method to measure in-vivo viscoelastic properties of tendons. Ultrasound in Medicine & Biology. 2015;41(6):1518-1529'},{id:"B18",body:'Sébastien A, Jean-Philippe N, Mickaël T, Fabio B, Chrystelle V, Fabrice M. Viscoelasticity in achilles tendinopathy: Quantitative assessment by using real-time shear-wave elastography. Radiology. 2015;274(3)'},{id:"B19",body:'Tobias DZ, Christian F, Feuchtner Gudrun M, Vinzenz S, Markus R, Sabine KA. Real-time sonoelastography findings in healthy achilles tendons. AJR. 2009;193:W134-W138'},{id:"B20",body:'Dirrichs T, Quack V, Gatz M, et al. Shear wave elastography (SWE) for the evaluation of patients with tendinopathies. Academic Radiology. 2016;23(10):1204-1213'},{id:"B21",body:'Chen XM, Cui LG, He P, et al. Shear wave elastographic characterization of normal and torn achilles tendons a pilot study. Journal of Ultrasound in Medicine. 2013;32(3):449-455'},{id:"B22",body:'De Zordo T, Chhem R, Smekal V, et al. Real-time sonoelastography: Findings in patients with symptomatic achilles tendons and comparison to healthy volunteers. Ultraschall in der Medizin. 2010;31(4):394-400'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Ahmad Mohammad Ghandour",address:"ahmed_ghandour@med.asu.edu.eg",affiliation:'
Department of Radiology, Faculty of Medicine, Ain Shams University Cairo, Egypt
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Some of these advanced pre-treatments include chemical washing to remove inks (deinking), extraction methods to remove undesired plastic additives and dissolution-based pre-treatments, such as delamination and dissolution-precipitation techniques.",signatures:"Rita Kol, Martijn Roosen, Sibel Ügdüler, Kevin M. Van Geem, Kim Ragaert, Dimitris S. Achilias and Steven De Meester",authors:[{id:"95620",title:"Dr.",name:"Dimitris S.",surname:"Achilias",fullName:"Dimitris S. 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I have also published, among others, several papers on vapor-liquid and liquid-liquid equilibria and prediction of critical properties of binary fluid mixtures with emphasis on hydrocarbon/gas mixtures.\nI have supervised 9 M.Sc. theses (7 in Jordan and 4 in UAE) in addition to other graduate and term projects and I was a member of the examining committee of many M.Sc. theses (CHE, ME, Chemistry, Environmental Science Master Program, and Water Resources Master Program) and an examiner in the qualifying exam for PhD students.\nI also supervised, among other works, a thesis on “Investigation on the Minimization of SO2 Emissions at Abu Dhabi Gas Liquefaction Company Limited (ADGAS) and Its Impact on Ambient Air Quality” and published two papers on that subject. \nIn addition, I have supervised many graduation projects during my career (and examiner of many others) that include process modeling, simulation, design and control as applied to oil and natural gas processing.\nI am the reviewer for many international scientific journals and associate editor of the Emirates Journal for Scientific Research (UAE University). I have over 300 citations for my published research in peer-reviewed journals.\nI have concentrated in my research on process modeling and simulation of chemical processes. I have organized and offered short courses on process modeling and simulation, process safety, risk assessment and analysis, and several others that are related to hydrocarbons processing and handling. I have been serving the community in many aspects at the various locations during my career. I have been a member of national committees (Standards and Codes, Non-CFC Standards, Jury Expert for Industrial Claims). I also supervised training at different industrial and professional entities. I have built a very good record with industry and received grants from different industries in Jordan (Jordan Phosphate Mines Co. and Arab Potash Co.) In the UAE I have received grants from (UAE University, General Holding Corporation for work on steel slag in cement manufacturing, Doosan Heavy Industries on desalination plants, Ministry of Presidential Affairs on Horizon for Petrochemicals in UAE, and recently from Emirates Foundation on photocatalytic conversion of CO2 back to hydrocarbons using TiO2 nanocatalyst and UV and/or visible light). I also received international grants from Japan Petroleum Institute and from Overseas Development Administration in Britain).\nI have been very competitive in getting research funding at the interdisciplinary and national levels and I am willing to engage myself in collaborative research, outstanding scholarly activities that will lead to national, regional and international recognition. In this regards, I have published 2 chapters in two books by Intech Open Access on “Ionic Liquids: Recycling for Reuse” in 2011 and \\Utilization of Ionic Liquids in Wood and Wood-Related Applications — A Review\\ in 2015",institutionString:null,institution:{name:"United Arab Emirates University",institutionURL:null,country:{name:"United Arab Emirates"}}},{id:"95620",title:"Dr.",name:"Dimitris S.",surname:"Achilias",slug:"dimitris-s.-achilias",fullName:"Dimitris S. Achilias",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/95620/images/system/95620.png",biography:"Dr. Dimitris S. Achilias is Professor of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki (AUTh), Greece. He completed his BSc and Ph.D. in the Chemical Engineering Department, AUTH, in 1985 and 1991, respectively. His research on polymer thermo-chemical recycling, synthesis of polymer nanocomposites, and polymerization/degradation kinetics has resulted in the publication of more than 170 research papers. Dr. Achilias has edited two books on recycling and is a member of the editorial board of the journal Polymers. 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If your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
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IMPORTANT: You must be a member or grantee of the listed funders in order to apply for their Open Access publication funds. Do not attempt to contact the funders if this is not the case.
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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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MRI is commonly used once treating brain, prostate cancers, ankle and foot. The Magnetic Resonance Imaging (MRI) images are usually liable to suffer from noises such as Gaussian noise, salt and pepper noise and speckle noise. So getting of brain image with accuracy is very extremely task. An accurate brain image is very necessary for further diagnosis process. During this chapter, a median filter algorithm will be modified. Gaussian noise and Salt and pepper noise will be added to MRI image. A proposed Median filter (MF), Adaptive Median filter (AMF) and Adaptive Wiener filter (AWF) will be implemented. The filters will be used to remove the additive noises present in the MRI images. The noise density will be added gradually to MRI image to compare performance of the filters evaluation. The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",book:{id:"6144",slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",title:"High-Resolution Neuroimaging",fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications"},signatures:"Hanafy M. Ali",authors:[{id:"213318",title:"Dr.",name:"Hanafy",middleName:"M.",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}]},{id:"41589",doi:"10.5772/50323",title:"The Role of the Amygdala in Anxiety Disorders",slug:"the-role-of-the-amygdala-in-anxiety-disorders",totalDownloads:9671,totalCrossrefCites:4,totalDimensionsCites:28,abstract:null,book:{id:"2599",slug:"the-amygdala-a-discrete-multitasking-manager",title:"The Amygdala",fullTitle:"The Amygdala - A Discrete Multitasking Manager"},signatures:"Gina L. Forster, Andrew M. Novick, Jamie L. Scholl and Michael J. Watt",authors:[{id:"145620",title:"Dr.",name:"Gina",middleName:null,surname:"Forster",slug:"gina-forster",fullName:"Gina Forster"},{id:"146553",title:"BSc.",name:"Andrew",middleName:null,surname:"Novick",slug:"andrew-novick",fullName:"Andrew Novick"},{id:"146554",title:"MSc.",name:"Jamie",middleName:null,surname:"Scholl",slug:"jamie-scholl",fullName:"Jamie Scholl"},{id:"146555",title:"Dr.",name:"Michael",middleName:null,surname:"Watt",slug:"michael-watt",fullName:"Michael Watt"}]},{id:"26258",doi:"10.5772/28300",title:"Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke",slug:"excitotoxicity-and-oxidative-stress-in-acute-ischemic-stroke",totalDownloads:7157,totalCrossrefCites:6,totalDimensionsCites:25,abstract:null,book:{id:"931",slug:"acute-ischemic-stroke",title:"Acute Ischemic Stroke",fullTitle:"Acute Ischemic Stroke"},signatures:"Ramón Rama Bretón and Julio César García Rodríguez",authors:[{id:"73430",title:"Prof.",name:"Ramon",middleName:null,surname:"Rama",slug:"ramon-rama",fullName:"Ramon Rama"},{id:"124643",title:"Prof.",name:"Julio Cesar",middleName:null,surname:"García",slug:"julio-cesar-garcia",fullName:"Julio Cesar García"}]},{id:"62072",doi:"10.5772/intechopen.78695",title:"Brain-Computer Interface and Motor Imagery Training: The Role of Visual Feedback and Embodiment",slug:"brain-computer-interface-and-motor-imagery-training-the-role-of-visual-feedback-and-embodiment",totalDownloads:1439,totalCrossrefCites:13,totalDimensionsCites:23,abstract:"Controlling a brain-computer interface (BCI) is a difficult task that requires extensive training. Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192666,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]},{id:"63258",title:"Anatomy and Function of the Hypothalamus",slug:"anatomy-and-function-of-the-hypothalamus",totalDownloads:4558,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"The hypothalamus is a small but important area of the brain formed by various nucleus and nervous fibers. Through its neuronal connections, it is involved in many complex functions of the organism such as vegetative system control, homeostasis of the organism, thermoregulation, and also in adjusting the emotional behavior. The hypothalamus is involved in different daily activities like eating or drinking, in the control of the body’s temperature and energy maintenance, and in the process of memorizing. It also modulates the endocrine system through its connections with the pituitary gland. Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3478,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3601,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1331,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81998",title:"Understanding the Neuropathophysiology of Psychiatry Disorder Using Transcranial Magnetic Stimulation",slug:"understanding-the-neuropathophysiology-of-psychiatry-disorder-using-transcranial-magnetic-stimulatio",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.103748",abstract:"Transcranial magnetic stimulation (TMS) is a safe and non-invasive tool that allows researchers to probe and modulate intracortical circuits. The most important aspect of TMS is its ability to directly stimulate the cortical neurons, generating action potentials, without much effect on intervening tissue. This property can be leveraged to provide insight into the pathophysiology of various neuropsychiatric disorders. Using multiple patterns of stimulations (single, paired, or repetitive), different neurophysiological parameters can be elicited. Various TMS protocol helps in understanding the neurobiological basis of disorder and specific behaviors by allowing direct probing of the cortical areas and their interconnected networks. While single-pulse TMS can provide insight into the excitability and integrity of the corticospinal tract, paired-pulse TMS (ppTMS) can provide further insight into cortico-cortical connections and repetitive TMS (rTMS) into cortical mapping and modulating plasticity.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Jitender Jakhar, Manish Sarkar and Nand Kumar"},{id:"81646",title:"Cortical Plasticity under Ketamine: From Synapse to Map",slug:"cortical-plasticity-under-ketamine-from-synapse-to-map",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.104787",abstract:"Sensory systems need to process signals in a highly dynamic way to efficiently respond to variations in the animal’s environment. For instance, several studies showed that the visual system is subject to neuroplasticity since the neurons’ firing changes according to stimulus properties. This dynamic information processing might be supported by a network reorganization. Since antidepressants influence neurotransmission, they can be used to explore synaptic plasticity sustaining cortical map reorganization. To this goal, we investigated in the primary visual cortex (V1 of mouse and cat), the impact of ketamine on neuroplasticity through changes in neuronal orientation selectivity and the functional connectivity between V1 cells, using cross correlation analyses. We found that ketamine affects cortical orientation selectivity and alters the functional connectivity within an assembly. These data clearly highlight the role of the antidepressant drugs in inducing or modeling short-term plasticity in V1 which suggests that cortical processing is optimized and adapted to the properties of the stimulus.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Ouelhazi Afef, Rudy Lussiez and Molotchnikoff Stephane"},{id:"81582",title:"The Role of Cognitive Reserve in Executive Functioning and Its Relationship to Cognitive Decline and Dementia",slug:"the-role-of-cognitive-reserve-in-executive-functioning-and-its-relationship-to-cognitive-decline-and",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.104646",abstract:"In this chapter, we explore how cognitive reserve is implicated in coping with the negative consequences of brain pathology and age-related cognitive decline. Individual differences in cognitive performance are based on different brain mechanisms (neural reserve and neural compensation), and reflect, among others, the effect of education, occupational attainment, leisure activities, and social involvement. These cognitive reserve proxies have been extensively associated with efficient executive functioning. We discuss and focus particularly on the compensation mechanisms related to the frontal lobe and its protective role, in maintaining cognitive performance in old age or even mitigating the clinical expression of dementia.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Gabriela Álvares-Pereira, Carolina Maruta and Maria Vânia Silva-Nunes"},{id:"81488",title:"Aggression and Sexual Behavior: Overlapping or Distinct Roles of 5-HT1A and 5-HT1B Receptors",slug:"aggression-and-sexual-behavior-overlapping-or-distinct-roles-of-5-ht1a-and-5-ht1b-receptors",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.104872",abstract:"Distinct brain mechanisms for male aggressive and sexual behavior are present in mammalian species, including man. However, recent evidence suggests a strong connection and even overlap in the central nervous system (CNS) circuitry involved in aggressive and sexual behavior. The serotonergic system in the CNS is strongly involved in male aggressive and sexual behavior. In particular, 5-HT1A and 5-HT1B receptors seem to play a critical role in the modulation of these behaviors. The present chapter focuses on the effects of 5-HT1A- and 5-HT1B-receptor ligands in male rodent aggression and sexual behavior. Results indicate that 5-HT1B-heteroreceptors play a critical role in the modulation of male offensive behavior, although a definite role of 5-HT1A-auto- or heteroreceptors cannot be ruled out. 5-HT1A receptors are clearly involved in male sexual behavior, although it has to be yet unraveled whether 5-HT1A-auto- or heteroreceptors are important. Although several key nodes in the complex circuitry of aggression and sexual behavior are known, in particular in the medial hypothalamus, a clear link or connection to these critical structures and the serotonergic key receptors is yet to be determined. This information is urgently needed to detect and develop new selective anti-aggressive (serenic) and pro-sexual drugs for human applications.",book:{id:"10195",title:"Serotonin and the CNS - New Developments in Pharmacology and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg"},signatures:"Berend Olivier and Jocelien D.A. Olivier"},{id:"81093",title:"Prehospital and Emergency Room Airway Management in Traumatic Brain Injury",slug:"prehospital-and-emergency-room-airway-management-in-traumatic-brain-injury",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.104173",abstract:"Airway management in trauma is critical and may impact patient outcomes. Particularly in traumatic brain injury (TBI), depressed level of consciousness may be associated with compromised protective airway reflexes or apnea, which can increase the risk of aspiration or result in hypoxemia and worsen the secondary brain damage. Therefore, patients with TBI and Glasgow Coma Scale (GCS) ≤ 8 have been traditionally managed by prehospital or emergency room (ER) endotracheal intubation. However, recent evidence challenged this practice and even suggested that routine intubation may be harmful. This chapter will address the indications and optimal method of securing the airway, prehospital and in the ER, in patients with traumatic brain injury.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Dominik A. Jakob, Jean-Cyrille Pitteloud and Demetrios Demetriades"},{id:"81011",title:"Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications",slug:"amino-acids-as-neurotransmitters-the-balance-between-excitation-and-inhibition-as-a-background-for-f",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.103760",abstract:"For more than 30 years, amino acids have been well-known (and essential) participants in neurotransmission. They act as both neuromediators and metabolites in nervous tissue. Glycine and glutamic acid (glutamate) are prominent examples. These amino acids are agonists of inhibitory and excitatory membrane receptors, respectively. Moreover, they play essential roles in metabolic pathways and energy transformation in neurons and astrocytes. Despite their obvious effects on the brain, their potential role in therapeutic methods remains uncertain in clinical practice. In the current chapter, a comparison of the crosstalk between these two systems, which are responsible for excitation and inhibition in neurons, is presented. The interactions are discussed at the metabolic, receptor, and transport levels. Reaction-diffusion and a convectional flow into the interstitial fluid create a balanced distribution of glycine and glutamate. Indeed, the neurons’ final physiological state is a result of a balance between the excitatory and inhibitory influences. However, changes to the glycine and/or glutamate pools under pathological conditions can alter the state of nervous tissue. Thus, new therapies for various diseases may be developed on the basis of amino acid medication.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Yaroslav R. Nartsissov"}],onlineFirstChaptersTotal:18},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:290,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:1,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
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\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"May 26th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. His research interests include optimization, computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, and intelligent systems. Prof. Sarfraz has been a keynote/invited speaker at various platforms around the globe. He has advised/supervised more than 110 students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He has authored and/or edited around seventy books. Prof. Sarfraz is a member of various professional societies. He is a chair and member of international advisory committees and organizing committees of numerous international conferences. He is also an editor and editor in chief for various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}},{id:"147824",title:"Mr.",name:"Pablo",middleName:null,surname:"Revuelta Sanz",slug:"pablo-revuelta-sanz",fullName:"Pablo Revuelta Sanz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. 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\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems. \r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
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",annualVolume:11966,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null,editorialBoard:[{id:"252368",title:"Dr.",name:"Meng-Chuan",middleName:null,surname:"Ong",fullName:"Meng-Chuan Ong",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRVotQAG/Profile_Picture_2022-05-20T12:04:28.jpg",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",institutionURL:null,country:{name:"Malaysia"}}},{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}},{id:"187907",title:"Dr.",name:"Olga",middleName:null,surname:"Anne",fullName:"Olga Anne",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBE5QAO/Profile_Picture_2022-04-07T09:42:13.png",institutionString:null,institution:{name:"Klaipeda State University of Applied Sciences",institutionURL:null,country:{name:"Lithuania"}}}]},{id:"39",title:"Environmental Resilience and Management",keywords:"Anthropic effects, Overexploitation, Biodiversity loss, Degradation, Inadequate Management, SDGs adequate practices",scope:"
\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
",annualVolume:11967,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null,editorialBoard:[{id:"177015",title:"Prof.",name:"Elke Jurandy",middleName:null,surname:"Bran Nogueira Cardoso",fullName:"Elke Jurandy Bran Nogueira Cardoso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGxzQAG/Profile_Picture_2022-03-25T08:32:33.jpg",institutionString:"Universidade de São Paulo, Brazil",institution:null},{id:"211260",title:"Dr.",name:"Sandra",middleName:null,surname:"Ricart",fullName:"Sandra Ricart",profilePictureURL:"https://mts.intechopen.com/storage/users/211260/images/system/211260.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}}]},{id:"40",title:"Ecosystems and Biodiversity",keywords:"Ecosystems, Biodiversity, Fauna, Taxonomy, Invasive species, Destruction of habitats, Overexploitation of natural resources, Pollution, Global warming, Conservation of natural spaces, Bioremediation",scope:"
\r\n\tIn general, the harsher the environmental conditions in an ecosystem, the lower the biodiversity. Changes in the environment caused by human activity accelerate the impoverishment of biodiversity.
\r\n
\r\n\tBiodiversity refers to “the variability of living organisms from any source, including terrestrial, marine and other aquatic ecosystems and the ecological complexes of which they are part; it includes diversity within each species, between species, and that of ecosystems”.
\r\n
\r\n\tBiodiversity provides food security and constitutes a gene pool for biotechnology, especially in the field of agriculture and medicine, and promotes the development of ecotourism.
\r\n
\r\n\tCurrently, biologists admit that we are witnessing the first phases of the seventh mass extinction caused by human intervention. It is estimated that the current rate of extinction is between a hundred and a thousand times faster than it was when man first appeared. The disappearance of species is caused not only by an accelerated rate of extinction, but also by a decrease in the rate of emergence of new species as human activities degrade the natural environment. The conservation of biological diversity is "a common concern of humanity" and an integral part of the development process. Its objectives are “the conservation of biological diversity, the sustainable use of its components, and the fair and equitable sharing of the benefits resulting from the use of genetic resources”.
\r\n
\r\n\tThe following are the main causes of biodiversity loss:
\r\n
\r\n\t• The destruction of natural habitats to expand urban and agricultural areas and to obtain timber, minerals and other natural resources.
\r\n
\r\n\t• The introduction of alien species into a habitat, whether intentionally or unintentionally which has an impact on the fauna and flora of the area, and as a result, they are reduced or become extinct.
\r\n
\r\n\t• Pollution from industrial and agricultural products, which devastate the fauna and flora, especially those in fresh water.
\r\n
\r\n\t• Global warming, which is seen as a threat to biological diversity, and will become increasingly important in the future.
",annualVolume:11968,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/40.jpg",editor:{id:"209149",title:"Prof.",name:"Salustiano",middleName:null,surname:"Mato",fullName:"Salustiano Mato",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLREQA4/Profile_Picture_2022-03-31T10:23:50.png",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorTwo:{id:"60498",title:"Prof.",name:"Josefina",middleName:null,surname:"Garrido",fullName:"Josefina Garrido",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRj1VQAS/Profile_Picture_2022-03-31T10:06:51.jpg",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorThree:{id:"464288",title:"Dr.",name:"Francisco",middleName:null,surname:"Ramil",fullName:"Francisco Ramil",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003RI7lHQAT/Profile_Picture_2022-03-31T10:15:35.png",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorialBoard:[{id:"220987",title:"Dr.",name:"António",middleName:"Onofre",surname:"Soares",fullName:"António Soares",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNtzQAG/Profile_Picture_1644499672340",institutionString:null,institution:{name:"University of the Azores",institutionURL:null,country:{name:"Portugal"}}}]},{id:"41",title:"Water Science",keywords:"Water, Water resources, Freshwater, Hydrological processes, Utilization, Protection",scope:"
\r\n\tWater is not only a crucial substance needed for biological life on Earth, but it is also a basic requirement for the existence and development of the human society. Owing to the importance of water to life on Earth, early researchers conducted numerous studies and analyses on the liquid form of water from the perspectives of chemistry, physics, earth science, and biology, and concluded that Earth is a "water polo". Water covers approximately 71% of Earth's surface. However, 97.2% of this water is seawater, 21.5% is icebergs and glaciers, and only 0.65% is freshwater that can be used directly by humans. As a result, the amount of water reserves available for human consumption is limited. The development, utilization, and protection of freshwater resources has become the focus of water science research for the continued improvement of human livelihoods and society.
\r\n
\r\n\tWater exists as solid, liquid, and gas within Earth’s atmosphere, lithosphere, and biosphere. Liquid water is used for a variety of purposes besides drinking, including power generation, ecology, landscaping, and shipping. Because water is involved in various environmental hydrological processes as well as numerous aspects of the economy and human society, the study of various phenomena in the hydrosphere, the laws governing their occurrence and development, the relationship between the hydrosphere and other spheres of Earth, and the relationship between water and social development, are all part of water science. Knowledge systems for water science are improving continuously. Water science has become a specialized field concerned with the identification of its physical, chemical, and biological properties. In addition, it reveals the laws of water distribution, movement, and circulation, and proposes methods and tools for water development, utilization, planning, management, and protection. Currently, the field of water science covers research related to topics such as hydrology, water resources and water environment. It also includes research on water related issues such as safety, engineering, economy, law, culture, information, and education.
",annualVolume:11969,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/41.jpg",editor:{id:"349630",title:"Dr.",name:"Yizi",middleName:null,surname:"Shang",fullName:"Yizi Shang",profilePictureURL:"https://mts.intechopen.com/storage/users/349630/images/system/349630.jpg",institutionString:"China Institute of Water Resources and Hydropower Research",institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"216491",title:"Dr.",name:"Charalampos",middleName:null,surname:"Skoulikaris",fullName:"Charalampos Skoulikaris",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRMsbQAG/Profile_Picture_2022-04-21T09:31:55.jpg",institutionString:null,institution:{name:"Aristotle University of Thessaloniki",institutionURL:null,country:{name:"Greece"}}},{id:"300124",title:"Prof.",name:"Thomas",middleName:null,surname:"Shahady",fullName:"Thomas Shahady",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002kuIgmQAE/Profile_Picture_2022-03-18T07:32:10.jpg",institutionString:null,institution:{name:"Lynchburg College",institutionURL:null,country:{name:"United States of America"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/421889",hash:"",query:{},params:{id:"421889"},fullPath:"/profiles/421889",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()