IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n
"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n
"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\n
In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\n
Feel free to share this news on social media and help us mark this memorable moment!
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n
"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n
"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\n
In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\n
Feel free to share this news on social media and help us mark this memorable moment!
\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"16",leadTitle:null,fullTitle:"Biomedical Engineering, Trends in Electronics, Communications and Software",title:"Biomedical Engineering, Trends in Electronics",subtitle:"Communications and Software",reviewType:"peer-reviewed",abstract:"Rapid technological developments in the last century have brought the field of biomedical engineering into a totally new realm. Breakthroughs in material science, imaging, electronics and more recently the information age have improved our understanding of the human body. As a result, the field of biomedical engineering is thriving with new innovations that aim to improve the quality and cost of medical care. This book is the first in a series of three that will present recent trends in biomedical engineering, with a particular focus on electronic and communication applications. More specifically: wireless monitoring, sensors, medical imaging and the management of medical information.",isbn:null,printIsbn:"978-953-307-475-7",pdfIsbn:"978-953-51-4534-9",doi:"10.5772/549",price:159,priceEur:175,priceUsd:205,slug:"biomedical-engineering-trends-in-electronics-communications-and-software",numberOfPages:750,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"d76a5792507e65ca56715b9661e8a66e",bookSignature:"Anthony N. Laskovski",publishedDate:"January 8th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/16.jpg",numberOfDownloads:122172,numberOfWosCitations:130,numberOfCrossrefCitations:81,numberOfCrossrefCitationsByBook:6,numberOfDimensionsCitations:164,numberOfDimensionsCitationsByBook:6,hasAltmetrics:0,numberOfTotalCitations:375,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 7th 2010",dateEndSecondStepPublish:"May 5th 2010",dateEndThirdStepPublish:"September 9th 2010",dateEndFourthStepPublish:"October 9th 2010",dateEndFifthStepPublish:"December 8th 2010",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"2205",title:"Dr.",name:"Anthony",middleName:"Nikola",surname:"Laskovski",slug:"anthony-laskovski",fullName:"Anthony Laskovski",profilePictureURL:"https://mts.intechopen.com/storage/users/2205/images/1554_n.jpg",biography:"Anthony N. Laskovski completed his Bachelor of Engineering (Electrical) Degree at the University of Newcastle, Australia in 2006 on a UNISS industrial scholarship with the power distributer Energy Australia.\nHis research interests include RF electronics and implantable electronic devices for biomedical applications, with a particular focus on wireless power transmitters, inductive coils and implantable telemetry architecture. His publications include various conference and journal papers and book chapters.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"692",title:"Biotechnology",slug:"engineering-biomedical-engineering-biotechnology"}],chapters:[{id:"12898",title:"Biosignal Monitoring Using Wireless Sensor Networks",doi:"10.5772/12946",slug:"biosignal-monitoring-using-wireless-sensor-networks",totalDownloads:4327,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Carlos Andres Lozano, Camilo Eduardo Tellez and Oscar Javier Rodriguez",downloadPdfUrl:"/chapter/pdf-download/12898",previewPdfUrl:"/chapter/pdf-preview/12898",authors:[{id:"13529",title:"Prof.",name:"Carlos",surname:"Lozano Garzon",slug:"carlos-lozano-garzon",fullName:"Carlos Lozano Garzon"},{id:"13530",title:"Prof.",name:"Oscar Javier",surname:"Rodriguez Riveros",slug:"oscar-javier-rodriguez-riveros",fullName:"Oscar Javier Rodriguez Riveros"},{id:"13531",title:"Prof.",name:"Camilo Eduardo",surname:"Tellez Villamizar",slug:"camilo-eduardo-tellez-villamizar",fullName:"Camilo Eduardo Tellez Villamizar"}],corrections:null},{id:"12899",title:"Wireless Telemetry for Implantable Biomedical Microsystems",doi:"10.5772/12997",slug:"wireless-telemetry-for-implantable-biomedical-microsystems",totalDownloads:5634,totalCrossrefCites:12,totalDimensionsCites:21,hasAltmetrics:0,abstract:null,signatures:"Farzad Asgarian and Amir M. Sodagar",downloadPdfUrl:"/chapter/pdf-download/12899",previewPdfUrl:"/chapter/pdf-preview/12899",authors:[{id:"13648",title:"Mr.",name:"Farzad",surname:"Asgarian",slug:"farzad-asgarian",fullName:"Farzad Asgarian"},{id:"15327",title:"Dr.",name:"Amir M.",surname:"Sodagar",slug:"amir-m.-sodagar",fullName:"Amir M. Sodagar"}],corrections:null},{id:"12900",title:"Microsystem Technologies for Biomedical Applications",doi:"10.5772/13340",slug:"microsystem-technologies-for-biomedical-applications",totalDownloads:3469,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Francisco Perdigones, Jose Miguel Moreno, Antonio Luque, Carmen Aracil and Jose Quero",downloadPdfUrl:"/chapter/pdf-download/12900",previewPdfUrl:"/chapter/pdf-preview/12900",authors:[{id:"14367",title:"BSc.",name:"Jose Miguel",surname:"Moreno Lopez",slug:"jose-miguel-moreno-lopez",fullName:"Jose Miguel Moreno Lopez"},{id:"14467",title:"Prof.",name:"Jose",surname:"Quero",slug:"jose-quero",fullName:"Jose Quero"},{id:"14942",title:"Prof.",name:"Francisco",surname:"Perdigones",slug:"francisco-perdigones",fullName:"Francisco Perdigones"},{id:"14943",title:"Dr.",name:"Antonio",surname:"Luque",slug:"antonio-luque",fullName:"Antonio Luque"},{id:"14944",title:"Prof.",name:"Carmen",surname:"Aracil",slug:"carmen-aracil",fullName:"Carmen Aracil"}],corrections:null},{id:"12901",title:"A Low Cost Instrumentation Based Sensor Array for Ankle Rehabilitation",doi:"10.5772/13852",slug:"a-low-cost-instrumentation-based-sensor-array-for-ankle-rehabilitation",totalDownloads:2715,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Samir Boukhenous and Mokhtar Attari",downloadPdfUrl:"/chapter/pdf-download/12901",previewPdfUrl:"/chapter/pdf-preview/12901",authors:[{id:"15442",title:"Dr.",name:"Samir",surname:"Boukhenous",slug:"samir-boukhenous",fullName:"Samir Boukhenous"}],corrections:null},{id:"12902",title:"New Neurostimulation Strategy and Corresponding Implantable Device to Enhance Bladder Functions",doi:"10.5772/13624",slug:"new-neurostimulation-strategy-and-corresponding-implantable-device-to-enhance-bladder-functions",totalDownloads:3134,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Faycal Mounaim and Mohamad Sawan",downloadPdfUrl:"/chapter/pdf-download/12902",previewPdfUrl:"/chapter/pdf-preview/12902",authors:[{id:"15436",title:"Dr.",name:"Faycal",surname:"Mounaim",slug:"faycal-mounaim",fullName:"Faycal Mounaim"},{id:"24137",title:"Prof.",name:"Mohamad",surname:"Sawan",slug:"mohamad-sawan",fullName:"Mohamad Sawan"}],corrections:null},{id:"12903",title:"Implementation of Microsensor Interface for Biomonitoring of Human Cognitive Processes",doi:"10.5772/12986",slug:"implementation-of-microsensor-interface-for-biomonitoring-of-human-cognitive-processes",totalDownloads:3025,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"E. Vavrinsky, P. Solarikova, V. Stopjakova, V. Tvarozek and I. Brezina",downloadPdfUrl:"/chapter/pdf-download/12903",previewPdfUrl:"/chapter/pdf-preview/12903",authors:[{id:"4932",title:"Dr.",name:"Erik",surname:"Vavrinsky",slug:"erik-vavrinsky",fullName:"Erik Vavrinsky"}],corrections:null},{id:"12904",title:"Wireless Communications and Power Supply for In Vivo Biomedical Devices Using Acoustic Transmissions",doi:"10.5772/13658",slug:"wireless-communications-and-power-supply-for-in-vivo-biomedical-devices-using-acoustic-transmissions",totalDownloads:2460,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Graham Wild and Steven Hinckley",downloadPdfUrl:"/chapter/pdf-download/12904",previewPdfUrl:"/chapter/pdf-preview/12904",authors:[{id:"2593",title:"Dr.",name:"Graham",surname:"Wild",slug:"graham-wild",fullName:"Graham Wild"},{id:"15691",title:"Prof.",name:"Steven",surname:"Hinckley",slug:"steven-hinckley",fullName:"Steven Hinckley"}],corrections:null},{id:"12905",title:"Power Amplifiers for Electronic Bio-Implants",doi:"10.5772/13557",slug:"power-amplifiers-for-electronic-bio-implants",totalDownloads:3296,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Anthony N. Laskovski and Mehmet R. Yuce",downloadPdfUrl:"/chapter/pdf-download/12905",previewPdfUrl:"/chapter/pdf-preview/12905",authors:[{id:"2205",title:"Dr.",name:"Anthony",surname:"Laskovski",slug:"anthony-laskovski",fullName:"Anthony Laskovski"},{id:"2184",title:"Dr.",name:"Mehmet",surname:"Rasit Yuce",slug:"mehmet-rasit-yuce",fullName:"Mehmet Rasit Yuce"}],corrections:null},{id:"12906",title:"Subthreshold Frequency Synthesis for Medical Implantable Transceivers",doi:"10.5772/14234",slug:"subthreshold-frequency-synthesis-for-medical-implantable-transceivers",totalDownloads:3363,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Tarek Khan and Kaamran Raahemifar",downloadPdfUrl:"/chapter/pdf-download/12906",previewPdfUrl:"/chapter/pdf-preview/12906",authors:[{id:"15481",title:"Prof.",name:"Tarek",surname:"Khan",slug:"tarek-khan",fullName:"Tarek Khan"},{id:"17241",title:"Dr.",name:"Kaamran",surname:"Raahemifar",slug:"kaamran-raahemifar",fullName:"Kaamran Raahemifar"}],corrections:null},{id:"12907",title:"Power Efficient ADCs for Biomedical Signal Acquisition",doi:"10.5772/13070",slug:"power-efficient-adcs-for-biomedical-signal-acquisition",totalDownloads:3429,totalCrossrefCites:4,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Alberto Rodríguez-Pérez, Manuel Delgado-Restituto and Fernando Medeiro",downloadPdfUrl:"/chapter/pdf-download/12907",previewPdfUrl:"/chapter/pdf-preview/12907",authors:[{id:"13771",title:"Dr.",name:"Alberto",surname:"Rodríguez-Pérez",slug:"alberto-rodriguez-perez",fullName:"Alberto Rodríguez-Pérez"},{id:"14909",title:"Dr.",name:"Manuel",surname:"Delgado-Restituto",slug:"manuel-delgado-restituto",fullName:"Manuel Delgado-Restituto"},{id:"14910",title:"Prof.",name:"Fernando",surname:"Medeiro",slug:"fernando-medeiro",fullName:"Fernando Medeiro"}],corrections:null},{id:"12908",title:"Cuff Pressure Pulse Waveforms: Their Current and Prospective Applications in Biomedical Instrumentation",doi:"10.5772/13475",slug:"cuff-pressure-pulse-waveforms-their-current-and-prospective-applications-in-biomedical-instrumentati",totalDownloads:3865,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:null,signatures:"Milan Stork and Jiri Jilek",downloadPdfUrl:"/chapter/pdf-download/12908",previewPdfUrl:"/chapter/pdf-preview/12908",authors:[{id:"14710",title:"Dr.",name:"Milan",surname:"Stork",slug:"milan-stork",fullName:"Milan Stork"},{id:"60736",title:"Dr.",name:"Jiri",surname:"Jilek",slug:"jiri-jilek",fullName:"Jiri Jilek"}],corrections:null},{id:"12909",title:"Integrated Microfluidic MEMS and Their Biomedical Applications",doi:"10.5772/13063",slug:"integrated-microfluidic-mems-and-their-biomedical-applications",totalDownloads:2844,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Abdulilah A. Dawoud Bani-Yaseen",downloadPdfUrl:"/chapter/pdf-download/12909",previewPdfUrl:"/chapter/pdf-preview/12909",authors:[{id:"13761",title:"Dr.",name:"Abdulilah",surname:"Bani-Yaseen",slug:"abdulilah-bani-yaseen",fullName:"Abdulilah Bani-Yaseen"}],corrections:null},{id:"12910",title:"MEMS Biomedical Sensor for Gait Analysis",doi:"10.5772/12905",slug:"mems-biomedical-sensor-for-gait-analysis",totalDownloads:4379,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Yufridin Wahab and Norantanum Abu Bakar",downloadPdfUrl:"/chapter/pdf-download/12910",previewPdfUrl:"/chapter/pdf-preview/12910",authors:[{id:"13450",title:"Dr.",name:"Yufridin",surname:"Wahab",slug:"yufridin-wahab",fullName:"Yufridin Wahab"}],corrections:null},{id:"12911",title:"Low-Wavelengths SOI CMOS Photosensors for Biomedical Applications",doi:"10.5772/12992",slug:"low-wavelengths-soi-cmos-photosensors-for-biomedical-applications",totalDownloads:2985,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Olivier Bulteel, Nancy Van Overstraeten-Schlögel, Aryan Afzalian, Pascal Dupuis, Sabine Jeumont, Leonid Irenge, Jérôme Ambroise, Benoit Macq, Jean-luc Gala and Denis Flandre",downloadPdfUrl:"/chapter/pdf-download/12911",previewPdfUrl:"/chapter/pdf-preview/12911",authors:[{id:"13635",title:"Prof.",name:"Olivier",surname:"Bulteel",slug:"olivier-bulteel",fullName:"Olivier Bulteel"},{id:"14838",title:"Dr.",name:"Aryan",surname:"Afzalian",slug:"aryan-afzalian",fullName:"Aryan Afzalian"},{id:"14839",title:"Dr.",name:"Pascal",surname:"Dupuis",slug:"pascal-dupuis",fullName:"Pascal Dupuis"},{id:"14840",title:"Dr.",name:"Nancy",surname:"Van Overstraeten-Schlögel",slug:"nancy-van-overstraeten-schlogel",fullName:"Nancy Van Overstraeten-Schlögel"},{id:"14841",title:"Prof.",name:"Sabine",surname:"Jeumont",slug:"sabine-jeumont",fullName:"Sabine Jeumont"},{id:"14842",title:"Dr.",name:"Leonid",surname:"Irenge",slug:"leonid-irenge",fullName:"Leonid Irenge"},{id:"14843",title:"Prof.",name:"Jérôme",surname:"Ambroise",slug:"jerome-ambroise",fullName:"Jérôme Ambroise"},{id:"14844",title:"Prof.",name:"Benoit",surname:"Macq",slug:"benoit-macq",fullName:"Benoit Macq"},{id:"14845",title:"Prof.",name:"Jean-Luc",surname:"Gala",slug:"jean-luc-gala",fullName:"Jean-Luc Gala"},{id:"14846",title:"Prof.",name:"Denis",surname:"Flandre",slug:"denis-flandre",fullName:"Denis Flandre"}],corrections:null},{id:"12912",title:"LEPTS – a Radiation-Matter Interaction Model at the Molecular Level and its Use in Biomedical Applications",doi:"10.5772/13061",slug:"lepts-a-radiation-matter-interaction-model-at-the-molecular-level-and-its-use-in-biomedical-applicat",totalDownloads:2576,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Martina Fuss, Ana G. Sanz, Antonio Muñoz, Francisco Blanco, Marina Téllez, Carlos Huerga and Gustavo Garcia",downloadPdfUrl:"/chapter/pdf-download/12912",previewPdfUrl:"/chapter/pdf-preview/12912",authors:[{id:"13757",title:"Dr.",name:"Gustavo",surname:"Garcia",slug:"gustavo-garcia",fullName:"Gustavo Garcia"},{id:"15284",title:"Prof.",name:"Martina",surname:"Fuss",slug:"martina-fuss",fullName:"Martina Fuss"},{id:"15285",title:"Prof.",name:"Ana G.",surname:"Sanz",slug:"ana-g.-sanz",fullName:"Ana G. Sanz"},{id:"15286",title:"Prof.",name:"Antonio",surname:"Muñoz",slug:"antonio-munoz",fullName:"Antonio Muñoz"},{id:"15287",title:"Dr.",name:"Francisco",surname:"Blanco",slug:"francisco-blanco",fullName:"Francisco Blanco"},{id:"15407",title:"Dr.",name:"Marina",surname:"Téllez",slug:"marina-tellez",fullName:"Marina Téllez"},{id:"15408",title:"Dr.",name:"Carlos",surname:"Huerga",slug:"carlos-huerga",fullName:"Carlos Huerga"}],corrections:null},{id:"12913",title:"Integrated High-Resolution Multi-Channel Time-to-Digital Converters (TDCs) for PET Imaging",doi:"10.5772/13080",slug:"integrated-high-resolution-multi-channel-time-to-digital-converters-tdcs-for-pet-imaging",totalDownloads:3937,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:0,abstract:null,signatures:"Wu Gao, Deyuan Gao, Christine Hu-Guo and Yann Hu",downloadPdfUrl:"/chapter/pdf-download/12913",previewPdfUrl:"/chapter/pdf-preview/12913",authors:[{id:"13783",title:"Dr.",name:"Wu",surname:"Gao",slug:"wu-gao",fullName:"Wu Gao"},{id:"13784",title:"Prof.",name:"Deyuan",surname:"Gao",slug:"deyuan-gao",fullName:"Deyuan Gao"},{id:"13785",title:"Prof.",name:"Yann",surname:"Hu",slug:"yann-hu",fullName:"Yann Hu"},{id:"14814",title:"Dr.",name:"Christine",surname:"Hu-Guo",slug:"christine-hu-guo",fullName:"Christine Hu-Guo"}],corrections:null},{id:"12914",title:"Parkinson's Disease Diagnosis and Prognosis Using Diffusion Tensor Medical Imaging Features Fusion",doi:"10.5772/13492",slug:"parkinson-s-disease-diagnosis-and-prognosis-using-diffusion-tensor-medical-imaging-features-fusion",totalDownloads:2656,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Roxana Oana Teodorescu, Vladimir-Ioan Cretu and Daniel Racoceanu",downloadPdfUrl:"/chapter/pdf-download/12914",previewPdfUrl:"/chapter/pdf-preview/12914",authors:[{id:"14892",title:"Dr.",name:"Roxana Oana",surname:"Teodorescu",slug:"roxana-oana-teodorescu",fullName:"Roxana Oana Teodorescu"},{id:"14894",title:"Prof.",name:"Vladimir Ioan",surname:"Cretu",slug:"vladimir-ioan-cretu",fullName:"Vladimir Ioan Cretu"},{id:"14895",title:"Prof.",name:"Daniel",surname:"Racoceanu",slug:"daniel-racoceanu",fullName:"Daniel Racoceanu"}],corrections:null},{id:"12915",title:"Non Invasive Foetal Monitoring with a Combined ECG - PCG System",doi:"10.5772/13554",slug:"non-invasive-foetal-monitoring-with-a-combined-ecg-pcg-system",totalDownloads:3979,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Mariano Ruffo, Mario Cesarelli, Craig Jin, Gaetano Gargiulo, Alistair McEwan, Colin Sullivan, Paolo Bifulco, Maria Romano, Richard W. Shephard, and André van Schaik",downloadPdfUrl:"/chapter/pdf-download/12915",previewPdfUrl:"/chapter/pdf-preview/12915",authors:[{id:"6212",title:"Dr.",name:"Gaetano",surname:"Gargiulo",slug:"gaetano-gargiulo",fullName:"Gaetano Gargiulo"},{id:"24068",title:"Prof.",name:"Paolo",surname:"Bifulco",slug:"paolo-bifulco",fullName:"Paolo Bifulco"},{id:"24069",title:"Prof.",name:"Mario",surname:"Cesarelli",slug:"mario-cesarelli",fullName:"Mario Cesarelli"},{id:"24070",title:"Prof.",name:"Colin",surname:"Sullivan",slug:"colin-sullivan",fullName:"Colin Sullivan"},{id:"24071",title:"Dr.",name:"André",surname:"van Shaik",slug:"andre-van-shaik",fullName:"André van Shaik"},{id:"24072",title:"Prof.",name:"Craig",surname:"Jin",slug:"craig-jin",fullName:"Craig Jin"},{id:"24073",title:"Prof.",name:"Mariano",surname:"Ruffo",slug:"mariano-ruffo",fullName:"Mariano Ruffo"},{id:"24080",title:"Dr.",name:"Maria",surname:"Romano",slug:"maria-romano",fullName:"Maria Romano"},{id:"24081",title:"Dr.",name:"Richard",surname:"Shephard",slug:"richard-shephard",fullName:"Richard Shephard"},{id:"24083",title:"Dr.",name:"Alistair",surname:"McEwan",slug:"alistair-mcewan",fullName:"Alistair McEwan"}],corrections:null},{id:"12916",title:"Parametric Modelling of EEG Data for the Identification of Mental Tasks",doi:"10.5772/13383",slug:"parametric-modelling-of-eeg-data-for-the-identification-of-mental-tasks",totalDownloads:4434,totalCrossrefCites:1,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Simon G. Fabri, Kenneth P. Camilleri and Tracey Cassar",downloadPdfUrl:"/chapter/pdf-download/12916",previewPdfUrl:"/chapter/pdf-preview/12916",authors:[{id:"14574",title:"Dr.",name:"Simon",surname:"Fabri",slug:"simon-fabri",fullName:"Simon Fabri"},{id:"14575",title:"Prof.",name:"Kenneth",surname:"Camilleri",slug:"kenneth-camilleri",fullName:"Kenneth Camilleri"},{id:"14588",title:"Prof.",name:"Tracey",surname:"Cassar",slug:"tracey-cassar",fullName:"Tracey Cassar"}],corrections:null},{id:"12917",title:"Automatic Detection of Paroxysms in EEG Signals Using Morphological Descriptors and Artificial Neural Networks",doi:"10.5772/13444",slug:"automatic-detection-of-paroxysms-in-eeg-signals-using-morphological-descriptors-and-artificial-neura",totalDownloads:2715,totalCrossrefCites:0,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Christine F. Boos, Fernando M. de Azevedo Geovani R. Scolaro and Maria do Carmo V. Pereira",downloadPdfUrl:"/chapter/pdf-download/12917",previewPdfUrl:"/chapter/pdf-preview/12917",authors:[{id:"14116",title:"Dr.",name:"Geovani Rodrigo",surname:"Scolaro",slug:"geovani-rodrigo-scolaro",fullName:"Geovani Rodrigo Scolaro"},{id:"14728",title:"M.Sc.",name:"Christine",surname:"Boos",slug:"christine-boos",fullName:"Christine Boos"},{id:"15302",title:"PhD.",name:"Maria Do Carmo",surname:"Pereira",slug:"maria-do-carmo-pereira",fullName:"Maria Do Carmo Pereira"},{id:"15303",title:"Dr.",name:"Fernando Mendes",surname:"De Azevedo",slug:"fernando-mendes-de-azevedo",fullName:"Fernando Mendes De Azevedo"}],corrections:null},{id:"12918",title:"Multivariate Frequency Domain Analysis of Causal Interactions in Physiological Time Series",doi:"10.5772/13065",slug:"multivariate-frequency-domain-analysis-of-causal-interactions-in-physiological-time-series",totalDownloads:3261,totalCrossrefCites:24,totalDimensionsCites:39,hasAltmetrics:0,abstract:null,signatures:"Luca Faes and Giandomenico Nollo",downloadPdfUrl:"/chapter/pdf-download/12918",previewPdfUrl:"/chapter/pdf-preview/12918",authors:[{id:"13764",title:"Dr.",name:"Luca",surname:"Faes",slug:"luca-faes",fullName:"Luca Faes"},{id:"14999",title:"Dr.",name:"Giandomenico",surname:"Nollo",slug:"giandomenico-nollo",fullName:"Giandomenico Nollo"}],corrections:null},{id:"12919",title:"Biomedical Image Segmentation Based on Multiple Image Features",doi:"10.5772/13490",slug:"biomedical-image-segmentation-based-on-multiple-image-features",totalDownloads:3191,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Jinhua Yu, Jinglu Tan and Yuanyuan Wang",downloadPdfUrl:"/chapter/pdf-download/12919",previewPdfUrl:"/chapter/pdf-preview/12919",authors:[{id:"14886",title:"Dr.",name:"Jinhua",surname:"Yu",slug:"jinhua-yu",fullName:"Jinhua Yu"},{id:"15335",title:"Dr.",name:"Jinglu",surname:"Tan",slug:"jinglu-tan",fullName:"Jinglu Tan"},{id:"24203",title:"Dr.",name:"Yuanyuan",surname:"Wang",slug:"yuanyuan-wang",fullName:"Yuanyuan Wang"}],corrections:null},{id:"12920",title:"A General Framework for Computation of Biomedical Image Moments",doi:"10.5772/13101",slug:"a-general-framework-for-computation-of-biomedical-image-moments",totalDownloads:2564,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"G.A. Papakostas, D.E. Koulouriotis, E.G. Karakasis and V.D. Tourassis",downloadPdfUrl:"/chapter/pdf-download/12920",previewPdfUrl:"/chapter/pdf-preview/12920",authors:[{id:"294154",title:"Prof.",name:"George",surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas"}],corrections:null},{id:"12921",title:"Modern Trends in Biomedical Image Analysis System Design",doi:"10.5772/13575",slug:"modern-trends-in-biomedical-image-analysis-system-design",totalDownloads:2793,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Oleh Berezsky, Grygoriy Melnyk and Yuriy Batko",downloadPdfUrl:"/chapter/pdf-download/12921",previewPdfUrl:"/chapter/pdf-preview/12921",authors:[{id:"15210",title:"Dr.",name:"Oleh",surname:"Berezsky",slug:"oleh-berezsky",fullName:"Oleh Berezsky"},{id:"15229",title:"MSc.",name:"Grygoriy",surname:"Melnyk",slug:"grygoriy-melnyk",fullName:"Grygoriy Melnyk"},{id:"15230",title:"MSc.",name:"Yuriy",surname:"Batko",slug:"yuriy-batko",fullName:"Yuriy Batko"}],corrections:null},{id:"12922",title:"A New Tool for Nonstationary and Nonlinear Signals: The Hilbert-Huang Transform in Biomedical Applications",doi:"10.5772/12871",slug:"a-new-tool-for-nonstationary-and-nonlinear-signals-the-hilbert-huang-transform-in-biomedical-applica",totalDownloads:5710,totalCrossrefCites:4,totalDimensionsCites:11,hasAltmetrics:0,abstract:null,signatures:"Rui Fonseca-Pinto",downloadPdfUrl:"/chapter/pdf-download/12922",previewPdfUrl:"/chapter/pdf-preview/12922",authors:[{id:"13354",title:"Prof.",name:"Rui",surname:"Fonseca-Pinto",slug:"rui-fonseca-pinto",fullName:"Rui Fonseca-Pinto"}],corrections:null},{id:"12923",title:"Periodic-MAC: Improving MAC Protocols for Wireless Biomedical Sensor Networks through Implicit Synchronization",doi:"10.5772/13223",slug:"periodic-mac-improving-mac-protocols-for-wireless-biomedical-sensor-networks-through-implicit-synchr",totalDownloads:2011,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Stig Støa and Ilangko Balasingham",downloadPdfUrl:"/chapter/pdf-download/12923",previewPdfUrl:"/chapter/pdf-preview/12923",authors:[{id:"14139",title:"Dr.",name:"Stig",surname:"Støa",slug:"stig-stoa",fullName:"Stig Støa"},{id:"14163",title:"Dr.",name:"Ilangko",surname:"Balasingham",slug:"ilangko-balasingham",fullName:"Ilangko Balasingham"}],corrections:null},{id:"12924",title:"Biomedical Electronic Systems to Improve the Healthcare Quality and Efficiency",doi:"10.5772/13112",slug:"biomedical-electronic-systems-to-improve-the-healthcare-quality-and-efficiency",totalDownloads:2893,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Roberto Marani and Anna Gina Perri",downloadPdfUrl:"/chapter/pdf-download/12924",previewPdfUrl:"/chapter/pdf-preview/12924",authors:[{id:"13841",title:"Prof.",name:"Anna Gina",surname:"Perri",slug:"anna-gina-perri",fullName:"Anna Gina Perri"},{id:"13842",title:"Dr.",name:"Roberto",surname:"Marani",slug:"roberto-marani",fullName:"Roberto Marani"}],corrections:null},{id:"12925",title:"Practical Causal Analysis for Biomedical Sensing Based on Human-Machine Collaboration",doi:"10.5772/13169",slug:"practical-causal-analysis-for-biomedical-sensing-based-on-human-machine-collaboration",totalDownloads:2263,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Naoki Tsuchiya and Hiroshi Nakajima",downloadPdfUrl:"/chapter/pdf-download/12925",previewPdfUrl:"/chapter/pdf-preview/12925",authors:[{id:"14011",title:"Prof.",name:"Naoki",surname:"Tsuchiya",slug:"naoki-tsuchiya",fullName:"Naoki Tsuchiya"},{id:"15358",title:"Dr.",name:"Hiroshi",surname:"Nakajima",slug:"hiroshi-nakajima",fullName:"Hiroshi Nakajima"}],corrections:null},{id:"12926",title:"Design Requirements for a Patient Administered Personal Electronic Health Record",doi:"10.5772/12948",slug:"design-requirements-for-a-patient-administered-personal-electronic-health-record",totalDownloads:2524,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Rune Fensli, Vladimir Oleshchuk, John O’Donoghue and Philip O’Reilly",downloadPdfUrl:"/chapter/pdf-download/12926",previewPdfUrl:"/chapter/pdf-preview/12926",authors:[{id:"13539",title:"Dr.",name:"Rune",surname:"Fensli",slug:"rune-fensli",fullName:"Rune Fensli"},{id:"15297",title:"Prof.",name:"Vladimir",surname:"Oleshchuk",slug:"vladimir-oleshchuk",fullName:"Vladimir Oleshchuk"},{id:"15298",title:"Prof.",name:"Philip",surname:"O'Reilly",slug:"philip-o'reilly",fullName:"Philip O'Reilly"},{id:"15299",title:"Dr.",name:"John",surname:"ODonoghue",slug:"john-odonoghue",fullName:"John ODonoghue"}],corrections:null},{id:"12927",title:"Nonparametric Variable Selection Using Machine Learning Algorithms in High Dimensional (Large P, Small N) Biomedical Applications",doi:"10.5772/13541",slug:"nonparametric-variable-selection-using-machine-learning-algorithms-in-high-dimensional-large-p-small",totalDownloads:2994,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Christina M.R. Kitchen",downloadPdfUrl:"/chapter/pdf-download/12927",previewPdfUrl:"/chapter/pdf-preview/12927",authors:[{id:"14763",title:"Prof.",name:"Christina",surname:"Ramirez Kitchen",slug:"christina-ramirez-kitchen",fullName:"Christina Ramirez Kitchen"}],corrections:null},{id:"12928",title:"Biomedical Knowledge Engineering Using a Computational Grid",doi:"10.5772/13809",slug:"biomedical-knowledge-engineering-using-a-computational-grid",totalDownloads:2034,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Marcello Castellano and Raffaele Stifini",downloadPdfUrl:"/chapter/pdf-download/12928",previewPdfUrl:"/chapter/pdf-preview/12928",authors:[{id:"13891",title:"Prof.",name:"Marcello",surname:"Castellano",slug:"marcello-castellano",fullName:"Marcello Castellano"},{id:"15986",title:"Prof.",name:"Raffaele",surname:"Stifini",slug:"raffaele-stifini",fullName:"Raffaele Stifini"}],corrections:null},{id:"12929",title:"Efficient Algorithms for Finding Maximum and Maximal Cliques: Effective Tools for Bioinformatics",doi:"10.5772/13245",slug:"efficient-algorithms-for-finding-maximum-and-maximal-cliques-effective-tools-for-bioinformatics",totalDownloads:10319,totalCrossrefCites:16,totalDimensionsCites:27,hasAltmetrics:0,abstract:null,signatures:"Etsuji Tomita, Tatsuya Akutsu and Tsutomu Matsunaga",downloadPdfUrl:"/chapter/pdf-download/12929",previewPdfUrl:"/chapter/pdf-preview/12929",authors:[{id:"14192",title:"Prof.",name:"Etsuji",surname:"Tomita",slug:"etsuji-tomita",fullName:"Etsuji Tomita"},{id:"14194",title:"Prof.",name:"Tatsuya",surname:"Akutsu",slug:"tatsuya-akutsu",fullName:"Tatsuya Akutsu"},{id:"14195",title:"Dr.",name:"Tsutomu",surname:"Matsunaga",slug:"tsutomu-matsunaga",fullName:"Tsutomu Matsunaga"}],corrections:null},{id:"12930",title:"A Software Development Framework for Agent-Based Infectious Disease Modelling",doi:"10.5772/13669",slug:"a-software-development-framework-for-agent-based-infectious-disease-modelling",totalDownloads:2843,totalCrossrefCites:0,totalDimensionsCites:7,hasAltmetrics:0,abstract:null,signatures:"Luiz C. Mostaço-Guidolin, Nick J. Pizzi, Aleksander B. Demko and Seyed M. Moghadas",downloadPdfUrl:"/chapter/pdf-download/12930",previewPdfUrl:"/chapter/pdf-preview/12930",authors:[{id:"15558",title:"Dr.",name:"Nick",surname:"Pizzi",slug:"nick-pizzi",fullName:"Nick Pizzi"},{id:"24044",title:"Prof.",name:"Luiz",surname:"Mostaço-Guidolin",slug:"luiz-mostaco-guidolin",fullName:"Luiz Mostaço-Guidolin"},{id:"24045",title:"Dr.",name:"Aleksander",surname:"Demko",slug:"aleksander-demko",fullName:"Aleksander Demko"},{id:"24046",title:"Dr.",name:"Seyed M.",surname:"Moghadas",slug:"seyed-m.-moghadas",fullName:"Seyed M. Moghadas"}],corrections:null},{id:"12931",title:"Personalized Biomedical Data Integration",doi:"10.5772/13017",slug:"personalized-biomedical-data-integration",totalDownloads:2446,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Xiaoming Wang, Olufunmilayo Olopade and Ian Foster",downloadPdfUrl:"/chapter/pdf-download/12931",previewPdfUrl:"/chapter/pdf-preview/12931",authors:[{id:"13647",title:"Prof.",name:"Xiaoming",surname:"Wang",slug:"xiaoming-wang",fullName:"Xiaoming Wang"},{id:"15026",title:"Prof.",name:"Ian",surname:"Forster",slug:"ian-forster",fullName:"Ian Forster"},{id:"15027",title:"Prof.",name:"Olufunmilayo",surname:"Olopade",slug:"olufunmilayo-olopade",fullName:"Olufunmilayo Olopade"}],corrections:null},{id:"12932",title:"Smart Data Collection and Management in Heterogeneous Ubiquitous Healthcare",doi:"10.5772/13458",slug:"smart-data-collection-and-management-in-heterogeneous-ubiquitous-healthcare",totalDownloads:2244,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Luca Catarinucci, Alessandra Esposito, Luciano Tarricone, Marco Zappatore and Riccardo Colella",downloadPdfUrl:"/chapter/pdf-download/12932",previewPdfUrl:"/chapter/pdf-preview/12932",authors:[{id:"14440",title:"Dr.",name:"Luciano",surname:"Tarricone",slug:"luciano-tarricone",fullName:"Luciano Tarricone"},{id:"14828",title:"Prof.",name:"Luca",surname:"Catarinucci",slug:"luca-catarinucci",fullName:"Luca Catarinucci"},{id:"14829",title:"Prof.",name:"Riccardo",surname:"Colella",slug:"riccardo-colella",fullName:"Riccardo Colella"},{id:"14830",title:"Prof.",name:"Alessandra",surname:"Esposito",slug:"alessandra-esposito",fullName:"Alessandra Esposito"},{id:"14831",title:"Prof.",name:"Marco",surname:"Zappatore",slug:"marco-zappatore",fullName:"Marco Zappatore"}],corrections:null},{id:"12933",title:"Quality of Service, Adaptation, and Security Provisioning in Wireless Patient Monitoring Systems",doi:"10.5772/13235",slug:"quality-of-service-adaptation-and-security-provisioning-in-wireless-patient-monitoring-systems",totalDownloads:2864,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"Wolfgang Leister, Trenton Schulz, Arne Lie, Knut Grythe and Ilangko Balasingham",downloadPdfUrl:"/chapter/pdf-download/12933",previewPdfUrl:"/chapter/pdf-preview/12933",authors:[{id:"14163",title:"Dr.",name:"Ilangko",surname:"Balasingham",slug:"ilangko-balasingham",fullName:"Ilangko Balasingham"},{id:"14161",title:"Dr.",name:"Wolfgang",surname:"Leister",slug:"wolfgang-leister",fullName:"Wolfgang Leister"},{id:"14164",title:"Dr.",name:"Arne",surname:"Lie",slug:"arne-lie",fullName:"Arne Lie"},{id:"14165",title:"Prof.",name:"Knut",surname:"Grythe",slug:"knut-grythe",fullName:"Knut Grythe"},{id:"14749",title:"MSc.",name:"Trenton",surname:"Schulz",slug:"trenton-schulz",fullName:"Trenton Schulz"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"481",title:"Biomedical Engineering",subtitle:"Trends in Materials Science",isOpenForSubmission:!1,hash:null,slug:"biomedical-engineering-trends-in-materials-science",bookSignature:"Anthony N. Laskovski",coverURL:"https://cdn.intechopen.com/books/images_new/481.jpg",editedByType:"Edited by",editors:[{id:"2205",title:"Dr.",name:"Anthony",surname:"Laskovski",slug:"anthony-laskovski",fullName:"Anthony Laskovski"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"509",title:"Biomedical Science, Engineering and Technology",subtitle:null,isOpenForSubmission:!1,hash:"eec1ae8717629372ed7f0c0499dee14c",slug:"biomedical-science-engineering-and-technology",bookSignature:"Dhanjoo N. Ghista",coverURL:"https://cdn.intechopen.com/books/images_new/509.jpg",editedByType:"Edited by",editors:[{id:"35845",title:"Prof.",name:"Dhanjoo N.",surname:"Ghista",slug:"dhanjoo-n.-ghista",fullName:"Dhanjoo N. Ghista"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3652",title:"Advances in Haptics",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"advances-in-haptics",bookSignature:"Mehrdad Hosseini Zadeh",coverURL:"https://cdn.intechopen.com/books/images_new/3652.jpg",editedByType:"Edited by",editors:[{id:"6239",title:"Dr.",name:"Mehrdad Hosseini",surname:"Zadeh",slug:"mehrdad-hosseini-zadeh",fullName:"Mehrdad Hosseini Zadeh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2241",title:"Biomedical Engineering",subtitle:"From Theory to Applications",isOpenForSubmission:!1,hash:"933a7a2f008c47fd232180ef1b3f0a8c",slug:"biomedical-engineering-from-theory-to-applications",bookSignature:"Reza Fazel-Rezai",coverURL:"https://cdn.intechopen.com/books/images_new/2241.jpg",editedByType:"Edited by",editors:[{id:"1995",title:"Dr.",name:"Reza",surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"508",title:"Biomedical Engineering",subtitle:"Frontiers and Challenges",isOpenForSubmission:!1,hash:"7f5bfc734fd607df80a0dc2fe965b313",slug:"biomedical-engineering-frontiers-and-challenges",bookSignature:"Reza Fazel-Rezai",coverURL:"https://cdn.intechopen.com/books/images_new/508.jpg",editedByType:"Edited by",editors:[{id:"1995",title:"Dr.",name:"Reza",surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"482",title:"Biomedical Engineering",subtitle:"Trends, Research and Technologies",isOpenForSubmission:!1,hash:"8ec55bcda429a187bb7ddb2920d2ddc0",slug:"biomedical-engineering-trends-research-and-technologies",bookSignature:"Malgorzata Anna Komorowska and Sylwia Olsztynska-Janus",coverURL:"https://cdn.intechopen.com/books/images_new/482.jpg",editedByType:"Edited by",editors:[{id:"58190",title:"Dr.",name:"Sylwia",surname:"Olsztynska",slug:"sylwia-olsztynska",fullName:"Sylwia Olsztynska"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3187",title:"Intelligent and Biosensors",subtitle:null,isOpenForSubmission:!1,hash:"f771fc891e588298df1acd59ba2a2185",slug:"intelligent-and-biosensors",bookSignature:"Vernon S. Somerset",coverURL:"https://cdn.intechopen.com/books/images_new/3187.jpg",editedByType:"Edited by",editors:[{id:"6648",title:"Associate Prof.",name:"Vernon",surname:"Somerset",slug:"vernon-somerset",fullName:"Vernon Somerset"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"238",title:"Applied Biomedical Engineering",subtitle:null,isOpenForSubmission:!1,hash:"b85b6fd9a3e8bedfbc1592745a0dfba3",slug:"applied-biomedical-engineering",bookSignature:"Gaetano D. Gargiulo and Alistair McEwan",coverURL:"https://cdn.intechopen.com/books/images_new/238.jpg",editedByType:"Edited by",editors:[{id:"24082",title:"Dr.",name:"Gaetano",surname:"Gargiulo",slug:"gaetano-gargiulo",fullName:"Gaetano Gargiulo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3185",title:"Biosensors",subtitle:null,isOpenForSubmission:!1,hash:"024d5c9c5c209691737a0729b92365ed",slug:"biosensors",bookSignature:"Pier Andrea Serra",coverURL:"https://cdn.intechopen.com/books/images_new/3185.jpg",editedByType:"Edited by",editors:[{id:"6091",title:"Prof.",name:"Pier Andrea",surname:"Serra",slug:"pier-andrea-serra",fullName:"Pier Andrea Serra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2215",title:"Biomedical Engineering",subtitle:"Technical Applications in Medicine",isOpenForSubmission:!1,hash:"db499ba76d3f33ce5d543946aa4dc072",slug:"biomedical-engineering-technical-applications-in-medicine",bookSignature:"Radovan Hudak, Marek Penhaker and Jaroslav Majernik",coverURL:"https://cdn.intechopen.com/books/images_new/2215.jpg",editedByType:"Edited by",editors:[{id:"145701",title:"Dr.",name:"Radovan",surname:"Hudak",slug:"radovan-hudak",fullName:"Radovan Hudak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"74511",slug:"corrigendum-to-has-the-yield-curve-accurately-predicted-the-malaysian-economy-in-the-previous-two-de",title:"Corrigendum to: Has the Yield Curve Accurately Predicted the Malaysian Economy in the Previous Two Decades?",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/74511.pdf",downloadPdfUrl:"/chapter/pdf-download/74511",previewPdfUrl:"/chapter/pdf-preview/74511",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/74511",risUrl:"/chapter/ris/74511",chapter:{id:"72452",slug:"has-the-yield-curve-accurately-predicted-the-malaysian-economy-in-the-previous-two-decades-",signatures:"Maya Puspa Rahman",dateSubmitted:"December 9th 2019",dateReviewed:"March 21st 2020",datePrePublished:"June 11th 2020",datePublished:"December 23rd 2020",book:{id:"9534",title:"Banking and Finance",subtitle:null,fullTitle:"Banking and Finance",slug:"banking-and-finance",publishedDate:"December 23rd 2020",bookSignature:"Razali Haron, Maizaitulaidawati Md Husin and Michael Murg",coverURL:"https://cdn.intechopen.com/books/images_new/9534.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"206517",title:"Associate Prof.",name:"Razali",middleName:null,surname:"Haron",slug:"razali-haron",fullName:"Razali Haron"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"316535",title:"Associate Prof.",name:"Maya Puspa",middleName:null,surname:"Rahman",fullName:"Maya Puspa Rahman",slug:"maya-puspa-rahman",email:"mayapuspa@iium.edu.my",position:null,institution:null}]}},chapter:{id:"72452",slug:"has-the-yield-curve-accurately-predicted-the-malaysian-economy-in-the-previous-two-decades-",signatures:"Maya Puspa Rahman",dateSubmitted:"December 9th 2019",dateReviewed:"March 21st 2020",datePrePublished:"June 11th 2020",datePublished:"December 23rd 2020",book:{id:"9534",title:"Banking and Finance",subtitle:null,fullTitle:"Banking and Finance",slug:"banking-and-finance",publishedDate:"December 23rd 2020",bookSignature:"Razali Haron, Maizaitulaidawati Md Husin and Michael Murg",coverURL:"https://cdn.intechopen.com/books/images_new/9534.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"206517",title:"Associate Prof.",name:"Razali",middleName:null,surname:"Haron",slug:"razali-haron",fullName:"Razali Haron"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"316535",title:"Associate Prof.",name:"Maya Puspa",middleName:null,surname:"Rahman",fullName:"Maya Puspa Rahman",slug:"maya-puspa-rahman",email:"mayapuspa@iium.edu.my",position:null,institution:null}]},book:{id:"9534",title:"Banking and Finance",subtitle:null,fullTitle:"Banking and Finance",slug:"banking-and-finance",publishedDate:"December 23rd 2020",bookSignature:"Razali Haron, Maizaitulaidawati Md Husin and Michael Murg",coverURL:"https://cdn.intechopen.com/books/images_new/9534.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"206517",title:"Associate Prof.",name:"Razali",middleName:null,surname:"Haron",slug:"razali-haron",fullName:"Razali Haron"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11627",leadTitle:null,title:"Oilseed Crops - Biology, Production and Processing",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tOil crops are an important class of agronomic crops and very important for the human diet. Oil crops not only provide edible oils but some of them have diverse uses like feeds, fuel, medicine, etc. These also contain many other mineral components in significant amounts and that is why the popularity of oil crops has increased in the last few decades. In the last few years, researchers have developed many new varieties and plant types of oil crops which has contributed to total edible oil production in the world. However, agronomic management, other production practices, and processing greatly vary depending on the plant types and the environment. Therefore, understanding the appropriate production and processing of oil crops is important. So, far researchers have gained considerable achievements in this area.
\r\n
\r\n\tThis book intends to provide the reader with a comprehensive overview of the various aspects of oil crops – their biology, production technologies, and processing.
",isbn:"978-1-80356-171-4",printIsbn:"978-1-80356-170-7",pdfIsbn:"978-1-80356-172-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"010cdbbb6a716d433e632b350d4dcafe",bookSignature:"Prof. Mirza Hasanuzzaman and MSc. Kamrun Nahar",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11627.jpg",keywords:"Plant Physiology, Abiotic Stress, Soil Management, Climate Change, Crop Management, Canola, Soybean, Sesame, Sunflower, Water Relations, Photosynthesis, Oil Content",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 3rd 2022",dateEndSecondStepPublish:"April 6th 2022",dateEndThirdStepPublish:"June 5th 2022",dateEndFourthStepPublish:"August 24th 2022",dateEndFifthStepPublish:"October 23rd 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Professor of Agronomy at Sher-e-Bangla Agricultural University in Dhaka whose publications have received about 9,500 citations (h-index 50 on Scopus). Recipient of the World Academy of Sciences Young Scientist Award and Publons Peer Review Award on 2017, 2018, and 2019.",coeditorOneBiosketch:"Professor at Sher-e-Bangla Agricultural University, Dhaka, and expert in Agricultural Botany and Plant Physiology. Dr. Nahar published 100 articles and chapters related to plant physiology and environmental stresses.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Sher-e-Bangla Agricultural University",institutionURL:null,country:{name:"Bangladesh"}}}],coeditorOne:{id:"166818",title:"MSc.",name:"Kamrun",middleName:null,surname:"Nahar",slug:"kamrun-nahar",fullName:"Kamrun Nahar",profilePictureURL:"https://mts.intechopen.com/storage/users/166818/images/system/166818.png",biography:"Dr. Kamrun Nahar is a Professor of Agricultural Botany at Sher-e-Bangla Agricultural University, Bangladesh. She received her Ph.D. in Environmental Stress Physiology of Plants from the United Graduate School of Agricultural Sciences, Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Dr. Nahar has been involved in research with field crops emphasizing stress physiology since 2006. She has completed several research works and is currently working on a research project funded by Sher-eBangla Agricultural University Research System and the Ministry of Science and Technology, Bangladesh. She is also supervising MS students. Dr. Nahar has published more than 100 articles and book chapters related to plant physiology and environmental stresses. Her publications have received about 9,500 citations with an h-index of 51. She is involved in editorial activities and is a reviewer of international journals. She is an active member of about twenty professional societies. Dr. Nahar has attended numerous international conferences and presented twenty papers and posters at these conferences.",institutionString:"Sher-e-Bangla Agricultural University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"247865",firstName:"Jasna",lastName:"Bozic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/247865/images/7225_n.jpg",email:"jasna.b@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"9345",title:"Sustainable Crop Production",subtitle:null,isOpenForSubmission:!1,hash:"5135c48a58f18229b288f2c690257bcb",slug:"sustainable-crop-production",bookSignature:"Mirza Hasanuzzaman, Marcelo Carvalho Minhoto Teixeira Filho, Masayuki Fujita and Thiago Assis Rodrigues Nogueira",coverURL:"https://cdn.intechopen.com/books/images_new/9345.jpg",editedByType:"Edited by",editors:[{id:"76477",title:"Prof.",name:"Mirza",surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10165",title:"Legume Crops",subtitle:"Prospects, Production and Uses",isOpenForSubmission:!1,hash:"5ce648cbd64755df57dd7c67c9b17f18",slug:"legume-crops-prospects-production-and-uses",bookSignature:"Mirza Hasanuzzaman",coverURL:"https://cdn.intechopen.com/books/images_new/10165.jpg",editedByType:"Edited by",editors:[{id:"76477",title:"Prof.",name:"Mirza",surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6418",title:"Hyperspectral Imaging in Agriculture, Food and Environment",subtitle:null,isOpenForSubmission:!1,hash:"9005c36534a5dc065577a011aea13d4d",slug:"hyperspectral-imaging-in-agriculture-food-and-environment",bookSignature:"Alejandro Isabel Luna Maldonado, Humberto Rodríguez Fuentes and Juan Antonio Vidales Contreras",coverURL:"https://cdn.intechopen.com/books/images_new/6418.jpg",editedByType:"Edited by",editors:[{id:"105774",title:"Prof.",name:"Alejandro Isabel",surname:"Luna Maldonado",slug:"alejandro-isabel-luna-maldonado",fullName:"Alejandro Isabel Luna Maldonado"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10359",title:"Landraces",subtitle:"Traditional Variety and Natural Breed",isOpenForSubmission:!1,hash:"0600836fb2c422f7b624363d1e854f68",slug:"landraces-traditional-variety-and-natural-breed",bookSignature:"Amr Elkelish",coverURL:"https://cdn.intechopen.com/books/images_new/10359.jpg",editedByType:"Edited by",editors:[{id:"231337",title:"Dr.",name:"Amr",surname:"Elkelish",slug:"amr-elkelish",fullName:"Amr Elkelish"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"31316",title:"Depressive Disorders and Thyroid Function",doi:"10.5772/35325",slug:"depressive-disorders-and-thyroid-function",body:'\n\t\t
\n\t\t\t
1. Introduction
\n\t\t\t
The complex relationship of thyroid hormones (TH) with brain function is known since a century. The TH mediate important effects on central nervous system (CNS) during development and throughout life (Bauer et al., 2002a; Smith et al., 2002). Is well known that hyper and hypothyroidism are frequently associated with subtle behavioral and psychiatric symptoms. By the other side, patients with mood disorders show alterations in thyroid-stimulating hormone (TSH) release under thyrotropin-releasing hormone (TRH) stimulation although, circulating TH: triiodothyronine (T3) and thyroxine (T4) are usually in the normal range (Linkowski et al., 1981; Loosen, 1985; Larsen et al., 2004; Risco et al., 2003). Animal studies have provided considerable data on the reciprocal interactions between TH and neurotransmitter systems related with the pathogenesis of mood disorders (Bauer et al., 2002a). These studies provide the basis for several hypotheses, which propose that the modulatory effects of TH on mood are mediated by their actions on different neurotransmitter as norepinephrine and serotonin (Belmaker&Agam, 1998). There is also experimental evidence that some antidepressant drugs have some effects on brain TH concentration and T3 generation through a modulatory effect on deiodinases. Many trials have demonstrated that under certain conditions the use of TH can enhance or accelerate the therapeutic effects of antidepressants (Kirkegaard & Faber, 1998).
\n\t\t\t
Considering that major depression is currently viewed as a serious public health problem with significant social and economic consequences, we found interesting to review how thyroid function and brain could interact in depressive disorders and how some new aspects as evaluation of some polymorphism of deiodinases and neuroimaging, can help in identifying depressive subjects susceptible to be treat with TH.
\n\t\t
\n\t\t
\n\t\t\t
2. Thyroid hormones and brain
\n\t\t\t
Thyroid hormones participate in the normal neurological development increasing the rate of neuronal proliferation in the cerebellum, acting as the “time clock” to end neuronal proliferation, differentiation and also stimulating the development of neuronal processes, axons and dendrites. As well TH mediate effects on CNS occur throughout life (Bauer et al., 2002a; Smith et al., 2002). Different studies have demonstrated the presence of thyroid receptors in rat CNS with a particular distribution during development and adulthood (Bradley et al., 1992; Bradley et al., 1989). Thus, TH regulate the expression of genes implicated in myelination, neuronal and glial cell differentiation (Bernal, 2005; Bernal & Nunez, 1995) and neuronal viability and function (Smith et al., 2002). These hormones are able to modify cell morphology by acting on cytoskeleton machinery required for neuronal migration and outgrowth (Aniello et al., 1991; Morte et al., 2010). Additionally, TH are present in noradrenergic nuclei of CNS (Rozanov & Dratman, 1996) probably acting as neuromodulator or co-neurotransmitter (Dratman & Gordon, 1996). In line with this, TH increase β-adrenergic receptors levels (Ghosh & Das, 2007; Whybrow & Prange, 1981) and improve both cholinergic (Smith et al., 2002) and serotonin neurotransmission in animals (Bauer et al., 2002a). The effect of TH on serotonin (5 HT) has been explained by a desensitization of 5HT1A autoreceptor in the raphe nuclei which probably results in enhancement of firing and release of serotonin from raphe neurons (Heal & Smith, 1988). Furthermore, these hormones can stimulate the expression of neuronal growth factor (NGF) suggesting certain trophic actions on CNS (Walker et al., 1979; Walker et al., 1981).
\n\t\t\t
In mice models, maternal hypo and hyperthyroidism cause some malformation and developmental defects in the cerebellar and cerebral cortex of their newborns. Concomitantly, there is some degeneration, deformation and severe growth retardation in neurons of these regions in both groups (El-Bakry et al., 2010). Therefore, TH play an important role in brain development, neuronal migration and axonal projection to target cells. In vitro and in vivo studies have shown that TH exert a non genomic action over the actin citoskeleton development in astrocytes and neurons. The lack of TH impaire cell growth, granule cells migration and explain those defects in the hypothyroid brain (Farwell et al., 2006; Leonard&Farwell, 1997; Farwell&Dubord, 1996).
\n\t\t\t
Moreover, both acute and chronic Thyroxine treatment in rats increases the cognitive function, probably through an enhancement in cholinergic neurotransmission (Smith et al., 2002).
\n\t\t\t
In humans, TH deficiency during the fetal and postnatal periods may cause irreversible mental retardation, neurological and behavioral deficits, and long lasting, irreversible motor dysfunctions. In adulthood, hypothyroidism may also determine profound behavioral consequences such as depressive symptoms, impaired memory, impairment in learning, verbal fluency, and spatial tasks (Miller et al., 2007; Samuels et al., 2007). Probably these alterations are due to neurotransmission impairment in brain areas related to learning and memory, such as hippocampus. Thus, the reduction of TH levels in CNS, can promote an altered neurotransmission activity contributing to some mood disorders like major depression.
\n\t\t\t
The biologically active thyroid hormone T3 exerts its effects by interacting with their specific nuclear thyroid receptors (TRs) that are positively regulated by its own ligand, acting as transcription factors. TRs are encoded for two different genes: TRβ located on chromosome 3, encodes three isoforms: β1, β2 and β3, and TRα located on chromosome 17, encodes the isoforms α1, α2 and α3. TRα1 is expressed early in the embryonic development and TRβ is expressed at later stages of development. By the other hand, the expression of these isoforms is tissue dependent; in the brain, the main isoforms of TRs are: TRα1, TRα2, TRβ1 and TRβ2. TRα1 and α2 accounting for most of TRs in the organ, whereas TRβ1 and β2 are detected in only a few areas as retina, cochlea, anterior pituitary and hypothalamus. In mice in which TRα or TRβ were inactivated, different phenotypes are observed indicating that TRs isoforms mediate specific functions but also, they can substitute each other to mediate some actions of T3 (Jones et al., 2007; Forrest et al., 1996a; Forrest et al., 1996b; Wikström et al., 1998; Fraichard et al., 1997; Göthe et al., 1999).
\n\t\t\t
Some studies have reported, in propylthiouracyl-induced hypothyroidal adult rats, a decreased expression of TRα1 and TRβ in the hippocampus, associated with an increase in β-amyloid peptides in the same area. Hypoactivity of the thyroid signaling in the hippocampus could induce modifications in the amiloydogenic pathway and this could be related with a greater vulnerability of developing Alzheimer disease in hypothyroidal subjects (Ghenimi et al., 2010).
\n\t\t\t
\n\t\t\t\t
2.1. T3 generation in the central nervous system: The importance of deiodinases
\n\t\t\t\t
Although both forms of TH (T4, T3) are present in the circulating blood, some studies have demonstrated that T4 is transported into the brain much more efficiently than T3 (Hagen & Solberg, 1974). In contrast to peripheral tissue, in the brain T4 and T3 are in equimolar range indicating mechanisms for an efficient transformation into biological active hormone.
\n\t\t\t\t
TH production is regulated by the HPT axis, while its biological activity is mainly regulated by three selenodeiodinasas coded by different genes (D1, D2, D3). Deiodinases act at prereceptor level influencing both, extracellular and intracellular TH levels and its action. Whether it activates or inactivates it, will depend on the level where deiodination occurs (5 or 5` position on the iodothyronine molecule). In the periphery, in the kidney and liver, D1 isoform is responsible for the production of most of the circulating T3 (Bianco et al., 2002).
\n\t\t\t\t
In the CNS, the most important isoforms are D2 and D3. In the brain, T3 is produced locally by the action of D2 which is also expressed in pituitary, thyroid, brown adipose tissue, skeletal muscle, and aortic smooth muscle cell, in humans. D2 activity varies extensively in different brain regions, with the highest levels found in cortical areas and lesser activity in the midbrain, pons, hypothalamus and brainstem (Bianco et al., 2002; Gouveia et al., 2005; Zavacki et al., 2005). It has been described in adult rats, that approximately 80% of T3 bound to nuclear receptors is produced locally by D2 activity (Crantz et al., 1982). Moreover, inactivation of TH is mainly carried out by D3 as well as glucoronosyltransferase and sulfotransferases. D3 is highly expressed within the CNS, with low peripheral expression. D3 degrades T4 to rT3 and T3 to 3,3′-diiodothyronine (T2) therefore preventing or finishing actions of T3. Thus, combined actions of D2 and D3 can locally increase or decrease thyroid hormone signaling in a tissue -and a temporal- fashion, and more importantly in a way independent of thyroid hormone plasma levels. In addition, increasing evidences pointed out that deiodinase expression can be modulated by a wide variety of endogenous signaling molecules, suggesting a local modulation of T3 production in the brain (Gereben et al., 2008a, Gereben et al., 2008b). D2 enzymatic activity is increased also in hypothyroidism and decreased in hyperthyroidism (Kirkegaard & Faber, 1998).
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
2.2. Association between deionidase polymorphisms and thyroid hormone metabolism
\n\t\t\t\t
Genetic variations in deionidade genes may impact significantly thyroid function and TH levels in euthyroid subjects (Hansen et al., 2007; Peeters et al., 2007; Peeters et al., 2006; Peeters et al., 2003). The effect of two polymorphisms in D1 gene, D1-rs11206244 (D1-C785T) and D1-rs12095080 (D1-A1814G) on thyroid hormone metabolism has been evaluated in randomly selected subjects (Peeters et al., 2003). The allele T of D1-rs11206244 was associated with high levels of rT3 and high rT3/T4 ratio and a low T3/rT3 in plasma; whereas the G allele of D1-A1814G was associated with a high T3/rT3 (de Jong et al., 2007; Peeters et al., 2003). These results suggest a lower activity in T carriers of rs11206244 than G carriers (Peeters et al., 2003).
\n\t\t\t\t
Of special interest is the common polymorphism in humans: D2 rs225014 (D2-Thr92Ala), characterized by a threonine (Thr) change to alanine (Ala) at codon 92 (D2 Thr92Ala). It is associated with insulin resistance in different populations, suggesting that D2-generated T3 in skeletal muscle plays a role in insulin sensitivity (Mentuccia et al., 2002, Canani et al., 2005). The minor allele (G) is associated with a low D2 activity in thyroid samples obtained from patients (Canani et al., 2005). In accordance, G allele seems to predict the need for higher T4 intake in thyroidectomized patients (Torlontano et al., 2008). Nonetheless, it has been observed that GG subjects show a delayed serum T3 rise in response to TRH-mediated TSH secretion consistent with decreased D2 activity (Butler et al., 2010). Some studies have described a naturally occurring polymorphism located in 5\'-untranslated region of the D2 gene (Coppotelli et al., 2006). In healthy blood donors, the minor allele of this polymorphism (D2-ORFa-Asp variant, rs12885300) is associated with an increase in circulating T3/T4 ratio but not with plasma T3 and TSH levels, suggesting an increased D2 gene expression (Peeters et al., 2005). In agreement, in vitro studies suggested that D2-rs1288530 polymorphism leads to higher activity of D2 at the pituitary level (Coppotelli et al., 2006). In a long case-control Chinese study, the haplotypes ORFa-3Asp-92Ala and ORFa-3Gly-92Ala indicated higher susceptibility for bipolar disorders, while ORFa-3Asp-92Thr probably played a protective role (He et al., 2009). According to this evidence, it is feasible that variants of D2 gene can produce “brain hypothyroidism” limiting T3 action on CNS affecting brain neurotransmission.
\n\t\t\t
\n\t\t
\n\t\t
\n\t\t\t
3. Thyroid and depression
\n\t\t\t
The similarity and overlapping between symptoms of depression and thyroid disorders has been the theoretical base for the hypothesis regarding a possible relationship between both entities. As we mention above, hypothyroidism could induce cognitive dysfunction and depressive symptoms besides psychological distress in a very similar way to primary depression (Constant et al., 2005; Bould et al., 2011; Mowla et al., 2011). Likewise, TH effect as augmentation therapy in refractory depression, and thyroid disorders as risk factors for rapid-cycling in bipolar disorder sustain a possible association between both types of diseases.
\n\t\t\t
The involvement of HPT axis in the pathogenesis of depression is supported by multiple data. There are few studies that show normal range TH levels during a depressive episode; however most of them demonstrate diverse changes in different hormones associated with this axis. Concerning TSH levels, data are contradictory, some authors have reported a decrease in basal TSH values as well as in those observed in response to exogenous TRH (Forman-Hoffman & Philibert, 2006; Stipcević et al., 2008) and other studies showed TSH elevation in bipolar depression (Brouwer et al., 2005; Saxena et al., 2000).
\n\t\t\t
In reference to T3 levels, results are more conclusive, showing a trend to decrease in the presence of depression, as well as an association with high risk of long term relapse. In addition there seems to be a more pronounced T3 decrease in direct relation with the severity of depression (Stipcević et al, 2008; Saxena et al., 2000). Reported T4 levels in depression are also contradictory, since there is evidence showing a rise as well as a decrease of T4 during depressive episodes. (Saxena et al., 2000; Kirkegaard&Faber, 1998). In a study, with more than 6,000 subjects, it was shown that a low TSH and a high T4 levels were associated with depression specially in young men but, in women only a higher T4 levels correlated with current depression syndrome (Forman-Hoffman&Philibert, 2006). It is possible that these findings could be explained by a diversity of factors, such as differences in phenotypes of depressive patients, severity and duration of the disease, difficulties in isolating drugs effects in TH levels (antidepressants and mood stabilizers) and probably, gender and other differences.
\n\t\t\t
Overt thyroid disease is infrequent among depressive patients. Nevertheless, many authors have seen that a subgroup of depressive patients manifest a subclinical hypothyroidism and this might be a negative prognostic factor (Fountoulakis et al., 2006). On the other side, some antidepressants as lithium inhibits TH secretion and could increase antithyroid antibodies, promoting hypothyroidism in susceptible subjects (Emerson et al., 1972; Myers et al., 1985).
\n\t\t\t
There is still no hypothesis that can satisfactory integrate these data. Interactions between TH and neurotransmitters, gene expression and neurohormonal receptors are not clear yet. For instance, 5 HT seems to inhibit TRH secretion and somatostatin TSH secretion (Kirkegaard&Faber, 1998); both of them are reduced in cerebro spinal fluid (CSF) in patients with psychiatric illness and affective disorders (Gerner&Yamada, 1982, Roy-Birne et al., 1983; Rubinow et al., 1983). Otherwise, T3 influx to intracellular level in the brain is determined by many factors, including T3 and T4 circulating levels, protein transporters, and deiodinase activity.
\n\t\t\t
About a 25% of major depressed patients show a reduction in TSH release under TRH stimulation (Loosen 1985, Risco et al, 2003). It has been proposed that in them exist a blunted response due to the raise of circulating cortisol, associated to hypothalamic-pituitary-adrenal axis hyperactivity. This response has also been observed in bipolar disorders (Linkowsky et al., 1981). On the other hand, in rapid cycling depressives, TSH hypersecretion is observed in response to TRH (20% of basal TSH levels above the normal range) (Szabadi, 1991, Larsen et al., 2004).
\n\t\t\t
Nevertheless, as we mentioned before, the mechanism by which TH affect the adult brain is not completely clear, because the complex interactions between neurotransmitters and thyroid. One hypothesis is that TH modulate the number of post-synaptic β-adrenergic receptors in the cerebral cortex and cerebellum This could be relevant considering the influence of catecholamines deficit, mainly norepinephrine as a cause of depression (Atterwill et al., 1984). Another possible mechanism is the modulation of 5 HT and its receptors. It has been suggested that TH inhibit the impulse rate of neurons present at the raphe and reducing the release of 5HT. T3 administration to mice attenuates the function of 5HT1A and 5HT1B receptors, increasing the cortical and hippocampus synthesis and turnover of 5-HT. Administration of T3 plus electroconvulsive shock markedly potentiated its actions on 5-HT2-mediated responses. (Heal&Smith, 1988). These findings provide evidences for possible antidepressant effects of T3 and/or potentiating therapy by TH. This issue is relevant in patients suffering depressive disorders, related with reduction in mono amine neurotransmission such as serotonin (reviewed in Belmaker&Agam 2008).
\n\t\t\t
A positive correlation between serotonin levels and circulating T3 has been described in humans. Indirect evidences showed that brain serotonin is increased in hyperthyroidism and decreased in hypothyroidism (Singhal et al., 1975). In the last situation, this is reversed with TH replacement (Bauer et al., 2002b, Strawn et al., 2004). In depressed subjects, the decrease in serotoninergic tone could be related to lower brain T3 levels, perhaps due to a reduction of deiodinases activity. Furthermore, an imbalance in T3 conversion could account for depressive disorder and/or clinical outcome to antidepressants therapy. It has been suggested that in depression, T3 may favor the release of cortical 5-HT and thus synergize the response to antidepressants. Administration of desipramine a selective serotonergic reuptake inhibitor (SSRI) in rats, induces an increase of D2 activity and T3 concentration in cortical tissue. Interestingly, T4 concentrations were significantly lowered after administration of the antidepressant but, serum T3 levels were significantly reduced only after toxic dosis of desipramine. Other commonly used SSRI, fluoxetine also decreases D3 activity (Eravci et al., 2000). Based on these data, one might suggest that depression occurs by the inhibition of D2, determining decreased T3 levels and secondarily, reduced levels of brain 5HT.
\n\t\t\t
The efficacy of T3 as a supplement of sertraline therapy, another SSRI, was studied recently in relation D1 polymorphism (Cooper-Kazaz et al., 2009). Patients carrying the T allele of D1-rs11206244 showed a significant response to 8 week of antidepressant treatment in comparison with non-carriers of the allele. Additionally, there was no effect of T allele on sertraline response, suggesting that the polymorphism is not associated to antidepressant effect (Cooper-Kazaz et al., 2009). As we mentioned, the T allele of D1-rs11206244 showed lower T3 and higher rT3 than non-T carriers (de Jong et al., 2007; Peeters et al., 2003). Thus, it seems that patients genetically characterized by poor conversion of T4 to T3, are better responders to T3-antidepressant co-treatment (Cooper-Kazaz et al., 2007; 2008). Another study evaluated whether baseline thyroid function and D2 rs225014 (D2-Thr92Ala) predict response to paroxetine. It showed that high TSH levels predict the response, and heterozygous patients showed lower TSH levels than the wild-type allele (A) (Brouwer et al., 2006). However, up to date there is no study evaluating the influence of T3 and D2 polymorphisms on antidepressant response.
\n\t\t\t
Based on these observations, we evaluated the presence of D2 polymorphism related with a lower activity of the enzyme: D2-Thr92Ala (T/C). The polymorphism was analyzed in 61 euthyroid patients with depression and 48 subjects of a population sample using the PCR-RFLP method. Clinical response to fluoxetine was evaluated before and after 8 weeks of treatment, using Hamilton Scale for Depression (HAM-D). We found that the CC genotype of Thr92Ala polymorphism was more frequent in depressed subjects and in non-responders patients (unpublished data). We concluded that Thr92Ala polymorphism of D2 gene could be considered a predictive marker of clinical response to fluoxetine, and hence of pharmacological therapy, but more studies are needed to confirm this preliminary results.
\n\t\t\t
The presence of these polymorphisms could influence basal activity of type 2 deiodinase, and therefore of T3 bioavailability in the brain.
\n\t\t
\n\t\t
\n\t\t\t
4. Use of thyroid hormone in depression
\n\t\t\t
Several studies using thyroid hormones in the management of patients with mood disorders have been reported since the early seventies. TH have been used in euthyroid depressed patients to enhance the effects of antidepressants. In patients receiving electroconvulsive therapy, those treated with T3 required less sessions and presented less memory loss compared with placebo treated group (Stern et al., 1991). T3 has been employed in initial combination therapy, and T3 or T4 in refractary depression or non responder patients.
\n\t\t\t
T3 in doses of 20 to 50 μg is able to enhance the effect of tricyclic antidepressants and shorten the depression period but, many studies have not demonstrated differences in the number of patients recovered (Prange et al., 1969; Wilson et al., 1970; Coppen et al., 1972; Wheatley, 1972). A meta-analysis showed that when T3 was used in refractary depression in addition to tricyclic antidepressant therapy, patients treated with it were twice as likely to respond as controls, decreasing depression severity scores (Aronson et al., 1996). However, samples size were small and deserve more evidence. Other studies, using T3 augmentation to SSRI-resistant depression, observed an improvement in mood scores (Agid&Lerer, 2003, Iosifescu et al., 2005, Abraham et al., 2006). Some authors found that patients who responded to T3 had higher serum TSH levels than non-responders and T3 appears to be less effective in men than in women (Agid&Lerer, 2003). Other authors reported that patients with atypical depression experienced significantly greater clinical improvement in final HAM-D with higher rates of treatment response and remission compared to subjects with non-atypical major depressive disorder (Iosifescu et al., 2005). All those cases were treated mainly with fluoxetine in a daily dose of 20 to 40 mg/ and 25-50 μg of T3, with few side effects.
\n\t\t\t
L-thyroxine (T4) added to antidepressants has been used less frequently than T3. Some authors have suggested that T4 augmentation is less effective than T3 (Joffe&Singer, 1990) and that supra physiological doses (250-600 ug/day) are needed, as has been demonstrated in patients with resistant major depression or refractary uni and bipolar disorders (Baumgartner et al., 1994, Bauer et al., 1998, 2002). These results support the theory of a reduced deiodination of T4 compatible with an inhibition of the D2 or a stimulation of the D3 in brain tissues resulting in reduced local T3 concentration.
\n\t\t\t
Nevertheless, the addition of T4 (100 ug /day during 4 weeks) to serotoninergic antidepressants obtained remission in 11 of 12 female patients with a resistant depressive episode but, these results did not show association with T3, T4 or TSH levels (Łojko & Rybakowski, 2007).
\n\t\t\t
To date, the use of TH in mood disorders is controversial and the rationale for this therapy is still not completely clear. Main limitations of the studies are: small number of cases, lack of a placebo group, heterogeneity in diagnosis criteria, differences in observational period and in antidepressant therapy. For example, lithium has a known inhibitory effect on TH secretion; fluoxetine has a stimulatory effect over D2 as well as desipramine and both of them could induce deficit of T4.
\n\t\t\t
In this line, we evaluated a group of euthyroidal adult female patients with major depression according to DSM IV-R criteria. All of them were free of antidepressants for at least for 6 month. We studied the effect of adding T3 in a dose of 50 ug per day (n=11) or placebo (n=10), to the standard antidepressant therapy with fluoxetine during 8 weeks. At the end of the observational period final HAM-D scores were similar in both groups. (See Table 1). Patients in T3 group showed significant T4, T3 and TSH changes; but they remain clinically euthyroid during the whole treatment period. Their body mass index, heart rate and other clinical parameters did not change. The placebo group showed a non significant increase of THS at the end of the observation time (See Figure 1, unpublished results).
\n\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
T3 Group
\n\t\t\t\t\t\t
Placebo
\n\t\t\t\t\t\t
p
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
Age (y.o.)
\n\t\t\t\t\t\t
40±12
\n\t\t\t\t\t\t
36±10
\n\t\t\t\t\t\t
ns
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
Initial
\n\t\t\t\t\t\t
2m
\n\t\t\t\t\t\t
Initial
\n\t\t\t\t\t\t
2m
\n\t\t\t\t\t\t
Initial vs 2m
\n\t\t\t\t\t\t
Groups
\n\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t
HAM-D
\n\t\t\t\t\t\t
24±4
\n\t\t\t\t\t\t
8±4
\n\t\t\t\t\t\t
26±6
\n\t\t\t\t\t\t
7±4
\n\t\t\t\t\t\t
<0.0001
\n\t\t\t\t\t\t
ns
\n\t\t\t\t\t
\n\t\t\t\t
Table 1.
Age and Hamilton score (HAM-D) with 21 items, in the groups with T3 addition or placebo. Both initial and 2 months means±SD were similar (using non paired t student test). The difference between initial and 2 month was highly significant in both groups (using paired t tests).
\n\t\t\t
Figure 1.
TSH changes after addition of T3 or placebo in both groups. Measurements of TSH are shown at baseline, 1 month and 2 months using similar SSRI therapy. T3 hormone induced significant decreased TSH levels. No significant change was observed in placebo group.
\n\t\t\t
Summarizing, our results suggest that TH addition to SSRI therapy in euthyroid depressed patients is safe and has not deleterious clinical effects in spite of TSH changes during treatment. Although, we could not demonstrated in this particular group, a significant antidepressant effect.
\n\t\t
\n\t\t
\n\t\t\t
5. Hypothyroidism, depression and brain imaging
\n\t\t\t
Single-photon tomography (SPECT), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) are able to capture physiological events linked to underlying neuronal activity. They have been employed to image and quantify brain perfusion, flow and metabolism in several conditions as well as the radionuclide techniques have been used to map neurotransmissors, receptors, drug actions and many metabolic pathways. Functional imaging in mood disorders may show abnormalities at different brain levels that could normalize with therapy. Several serotonin and adrenergic markers have also been employed to study negative emotional stimuli response in mood disorders. For instance: thalamic activity was increased by reboxetine, whereas citalopram primarily affected ventrolateral prefrontal regions. It would be interesting to have a method able to predict therapy responses to either noradrenergic or serotoninergic antidepressants (Carey et al., 2004; Navarro et al., 2004; Zobel et al., 2005; Kohn et al., 2007; MacQueen, 2009; Brühl et al., 2011).
\n\t\t\t
It is also known that even mild hypothyroidism may produce changes in brain regions modulating attention, motor speed, memory and visual-spatial processing. In severe hypothyroidism induced by thyroidectomy in cancer patients, it have been reported a clear parietal and partial occipital lobe hypoperfusion, measured with SPECT; the abnormalities improved after reaching normal thyroid function, in some subjects. However, fluorodeoxyglucose (FDG) and oxygen-15-labeled water studies, in similar patients, showed lower global brain glucose metabolism and flow. Hypothyroidal patients were also significantly more depressed, anxious and psychomotor slowered than euthyroidal subjects (Nagamachi et al., 2004; Constant et al., 2001).
\n\t\t\t
Brain metabolism and flow are usually decreased in major depression and bipolar disease being metabolism inversely associated with the severity of depression. Changes are variable and as we mentioned earlier, could reverse with adequate therapy. Subgenual prefrontal cortex presents abnormal blood flow and metabolism in the depressed state. Prefrontal cortex and limbic structures are involved in emotion regulation and amygdale is involved in emotional memory formation (Buchsbaum et al., 1997; Kennedy et al., 2007; Chen et al., 2011). In major depression patients, glucose metabolism in orbitofrontal and inferior frontal cortex correlates with therapy response; responders have a significant decrease in the orbitofrontal and ventrolateral regions compared with non-responders, implicating ventral prefrontal subcortical circuits in response to specific therapy with SSRI. In major depression and bipolar patients, FDG has shown an inverse correlation between brain metabolism and circulating TSH (Brody et al., 1999; Marangell et al., 1997; Milak et al., 2005).
\n\t\t\t
Cerebral fMRI has been reported to be helpful in major depression intending to predict therapy response using brain activation. Morphometric studies have evaluated hippocampus volume association with response to treatment. Patients who remit have larger pretreatment hippocampus volumes bilaterally compared with those who do not remit. There are similar preliminary findings for the anterior cingulate cortex. A recent work demonstrated a significantly thinner posterior cingulate cortex in non-remitters than in remitters, and also significant decrease in perfusion in frontal lobes and anterior cingulate cortex in non-remitters compared with healthy controls, at baseline (MacQueen, 2009; Järnum et al., 2011).
\n\t\t\t
There are reports with increased perfusion in anterior cingulate and prefrontal medial cortex when using SSRI or amesergide. Responders and non-responders to cognitive behavior therapy versus antidepressive pharmacotherapy and deep brain stimulation could also be differentiated using brain perfusion SPECT or glucose metabolism with PET (Vlassenko et al., 2004; Kennedy et al., 2007; Richieri et al., 2011).
\n\t\t\t
Another work with fMRI demonstrated also that successful paroxetine treatment decreases amygdala activation, presumably by improved frontolimbic control, in line with SSRI, induced increased functional connectivity between pregenual anterior cingulated cortex, prefrontal cortex, and amygdala. Changes in amygdala activation when processing negative faces expressions might serve as an indicator for improved frontolimbic control required for clinical response (Ruhé, 2011).
\n\t\t\t
We recently studied a group of major depression middle age patients using brain perfusion SPECT, all in their first episode of major depression and /or without any specific therapy for at least six months. Their initial HAM-D scores corresponded to 24±4.8; all of them received standard SSRI therapy. Ninety-three percent were responders at 2 months (HAM-D decrease >50%) and 59% were remitters (HAM-D score ≤5). There was association of decreased perfusion in diverse brain areas with HAM-D changes in the whole group using Statistical Parametric Analysis (SPM) as covariate (See Figure 2). We did not observe significant neocortical perfusion change after 2 months of standard dose of fluoxetine therapy. However, there was a bilateral decrease in parahippocampal gyrus, thalamus and striatum as well as in anterior cingulate gyrus (Brodmann 32 area) after SSRI therapy. No significant difference was observed between remitters and non-remitters.
\n\t\t\t
Figure 2.
In the whole group, SPM8 analysis demonstrated association between decreased perfusion and HAM-D scores considered as a covariate, at baseline and after 2 months of therapy (non corrected p <0.001): -at left: in amygdala, anterior cingulate, globus pallidum, putamen and Brodmann area 9 (mid frontal gyrus) -bilaterally: both hyppocampal gyrus, mid and superior temporal and insulas and cerebellar hemispheres -at right: in central and supramarginal gyrus
\n\t\t\t
As we mentioned before, a half of the women in our group received T3 in addition of SSRI and the other half a placebo instead of T3. Our results showed no evidence that adding T3 to SSRI therapy in unipolar major depression females produces significant change in regional cerebral blood flow at neocortical level (See Figure 3). Only a small difference was found at deep structure level that could imply diverse brain mechanism involved [data not published].
\n\t\t\t
These findings are in agreement with other reports showing relative normalization of perfusion and metabolism that were abnormally increased at baseline in patients with mood disorders. Some of these regional metabolism changes are correlated with emotional behavior. The amygdala and limbic structures have been associated with face recognition and emotional processing. It is well known that there is increased perfusion and metabolism in specific brain areas, reflecting molecular abnormalities in neurotransmitter systems. The development of new molecular imaging methods could help in the individualization of antidepressant therapies (Chen et al., 2011).
\n\t\t
\n\t\t
Figure 3.
Absence of regional cerebral blood flow change after SSRI therapy in T3 group, using Statistical Parametric Analysis (SPM8) with significant level <0.001; uncorrected p value.
\n\t\t
\n\t\t\t
6. Conclusions
\n\t\t\t
Depressive and thyroid disorders are important public health problems. There is strong experimental evidence showing thyroid involvement on early stages of CNS development and on metabolic function of the mature brain. It is also accepted that overt hyper or hypothyroidism are not found frequently among mood disorders patients except in those with bipolar disorders, indicating that in most cases the underlying abnormality is at cellular or molecular levels. Although there is a prolific literature on the relationship between thyroid function and depressive disorders, clear results in humans on the role of TH in antidepressant therapy are still lacking. There are no randomized controlled trials, and the number of patients included in existing studies is too small. On the other hand, more research is needed in order to define the importance of genetic variants in deiodinases and the role of neuroimaging into the complex interactions between HPT function and mood disorders and in clinical response to treatments.
\n\t\t\t
Therefore, considering the available evidence and our own experience, we can recommend this strategy only as an alternative treatment in major depression patients who have failed to respond to other measures.
\n\t\t
\n\t\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/31316.pdf",chapterXML:"https://mts.intechopen.com/source/xml/31316.xml",downloadPdfUrl:"/chapter/pdf-download/31316",previewPdfUrl:"/chapter/pdf-preview/31316",totalDownloads:3029,totalViews:222,totalCrossrefCites:0,totalDimensionsCites:1,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:56,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"May 10th 2011",dateReviewed:"October 18th 2011",datePrePublished:null,datePublished:"March 7th 2012",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/31316",risUrl:"/chapter/ris/31316",book:{id:"1258",slug:"thyroid-and-parathyroid-diseases-new-insights-into-some-old-and-some-new-issues"},signatures:"A. Verónica Araya, Teresa Massardo, Jenny Fiedler, Luis Risco, Juan C. Quintana and Claudio Liberman",authors:[{id:"40769",title:"Dr.",name:"Teresa",middleName:null,surname:"Massardo",fullName:"Teresa Massardo",slug:"teresa-massardo",email:"tmassardo@redclinicauchile.cl",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"56394",title:"Dr.",name:"Verónica",middleName:null,surname:"Araya",fullName:"Verónica Araya",slug:"veronica-araya",email:"varaya@redclinicauchile.cl",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"112810",title:"Dr.",name:"Jenny",middleName:null,surname:"Fieddler",fullName:"Jenny Fieddler",slug:"jenny-fieddler",email:"jfiedler@ciq.uchile.cl",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"112811",title:"Dr.",name:"Luis",middleName:null,surname:"Risco",fullName:"Luis Risco",slug:"luis-risco",email:"luis.risco@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"112812",title:"Dr.",name:"Claudio",middleName:null,surname:"Liberman",fullName:"Claudio Liberman",slug:"claudio-liberman",email:"cliberma@redclinicauchile.cl",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"137069",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Quintana",fullName:"Juan Carlos Quintana",slug:"juan-carlos-quintana",email:"jcquinta@med.puc.cl",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction ",level:"1"},{id:"sec_2",title:"2. Thyroid hormones and brain",level:"1"},{id:"sec_2_2",title:"2.1. T3 generation in the central nervous system: The importance of deiodinases ",level:"2"},{id:"sec_3_2",title:"2.2. Association between deionidase polymorphisms and thyroid hormone metabolism",level:"2"},{id:"sec_5",title:"3. Thyroid and depression ",level:"1"},{id:"sec_6",title:"4. Use of thyroid hormone in depression ",level:"1"},{id:"sec_7",title:"5. Hypothyroidism, depression and brain imaging ",level:"1"},{id:"sec_8",title:"6. Conclusions",level:"1"}],chapterReferences:[{id:"B1",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAbraham\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMilev\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStuart\n\t\t\t\t\t\t\tLawson. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2006\n\t\t\t\t\tT3 augmentation of SSRI resistant depression. Journal of Affective Disorders, 91\n\t\t\t\t\t2-3 (April 2006), 211\n\t\t\t\t\t215 .\n\t\t\t'},{id:"B2",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAgid\n\t\t\t\t\t\t\tO.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLerer\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2003\n\t\t\t\t\tAlgorithm-based treatment of major depression in an outpatient clinic: clinical correlates of response to a specific serotonin reuptake inhibitor and to triiodothyronine augmentation. International Journal of Neuropsychopharmacology, 6\n\t\t\t\t\t1 March 2003), 41\n\t\t\t\t\t49 .\n\t\t\t'},{id:"B3",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAltshuler\n\t\t\t\t\t\t\tL. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBauer\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFrye\n\t\t\t\t\t\t\tM. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGitlin\n\t\t\t\t\t\t\tM. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMintz\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSzuba\n\t\t\t\t\t\t\tM. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLeight\n\t\t\t\t\t\t\tK. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWhybrow\n\t\t\t\t\t\t\tP. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2001\n\t\t\t\t\tDoes thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature.\n\t\t\t\t\tAmerican Journal of Psychiatry, 158\n\t\t\t\t\t10 October 2001), 1617\n\t\t\t\t\t1622 .\n\t\t\t'},{id:"B4",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAniello\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCouchie\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBridoux\n\t\t\t\t\t\t\tA. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGripois\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNunez\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1991\n\t\t\t\t\tSplicing of juvenile and adult tau mRNA variants is regulated by thyroid hormone. Proceedings of National Academic of Sciences, 88\n\t\t\t\t\t9 May 1991), 4035\n\t\t\t\t\t4039 .\n\t\t\t'},{id:"B5",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAronson\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOffman\n\t\t\t\t\t\t\tH. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJoffe\n\t\t\t\t\t\t\tR. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNaylor\n\t\t\t\t\t\t\tC. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1996\n\t\t\t\t\tTriiodothyronine augmentation in the treatment of refractory depression. A meta-analysis.\n\t\t\t\t\tArchives General of Psychiatry, 53\n\t\t\t\t\t9 September 1996), 842\n\t\t\t\t\t848 .\n\t\t\t'},{id:"B6",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAtterwill\n\t\t\t\t\t\t\tC. K.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBunn\n\t\t\t\t\t\t\tS. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAtkinson\n\t\t\t\t\t\t\tD. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSmith\n\t\t\t\t\t\t\tS. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHeal\n\t\t\t\t\t\t\tD. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t(1984), Effects of thyroid status on presynaptic alpha 2-adrenoceptor function and beta-adrenoceptor binding in the rat brain.\n\t\t\t\t\tJournal of Neural Transmission, 59 591 N 1, 43\n\t\t\t\t\t55 .\n\t\t\t'},{id:"B7",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBauer\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHeinz\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWhybrow\n\t\t\t\t\t\t\tP. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002a\n\t\t\t\t\tThyroid hormones, serotonin and mood: of synergy and significance in the adult brain.\n\t\t\t\t\tMolecular Psychiatry, 7 N 2, (2002a) 140\n\t\t\t\t\t156 .\n\t\t\t'},{id:"B8",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBauer\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBerghöfer\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBschor\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaumgartner\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKiesslinger\n\t\t\t\t\t\t\tU.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHellweg\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAdli\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaethge\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMüller-Oerlinghausen\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002b\n\t\t\t\t\tSupraphysiological doses of L-Thyroxine in the maintenance treatment of prophylaxis-resistant affective disorders. Neuropsychopharmacology, 27\n\t\t\t\t\t4 October 2002), 620\n\t\t\t\t\t628 .\n\t\t\t'},{id:"B9",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBauer\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHellweg\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGräf\n\t\t\t\t\t\t\tK. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaumgartner\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1998\n\t\t\t\t\tTreatment of refractory depression with high-dose thyroxine. Neuropsychopharmacology, 18\n\t\t\t\t\t6 June 1998), 444\n\t\t\t\t\t455 .\n\t\t\t'},{id:"B10",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaumgartner\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBauer\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHellweg\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1994\n\t\t\t\t\tTreatment of intractable non-rapid cycling bipolar affective disorder with high-dose thyroxine: An open trial. Neuropsychopharmacology, 10\n\t\t\t\t\t3 May 1994), 183\n\t\t\t\t\t189 .\n\t\t\t'},{id:"B11",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBelmaker\n\t\t\t\t\t\t\tR. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAgam\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2008\n\t\t\t\t\tMechanisms of Disease: Major Depressive Disorder. New England Journal of Medicine, 358\n\t\t\t\t\t1 January 2008), 55\n\t\t\t\t\t68 .\n\t\t\t'},{id:"B12",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBernal\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNunez\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1995\n\t\t\t\t\tThyroid hormones and brain development. European Journal of Endocrinology, 133\n\t\t\t\t\t4 October 1995), 390\n\t\t\t\t\t398 .\n\t\t\t'},{id:"B13",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBernal\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005\n\t\t\t\t\tThyroid hormones and brain development.\n\t\t\t\t\tVitamines and Hormones, 71\n\t\t\t\t\t95\n\t\t\t\t\t122 .\n\t\t\t'},{id:"B14",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBianco\n\t\t\t\t\t\t\tA. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSalvatore\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGereben\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBerry\n\t\t\t\t\t\t\tM. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLarsen\n\t\t\t\t\t\t\tP. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002\n\t\t\t\t\tBiochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocrine Reviews, 23\n\t\t\t\t\t1 February 2002), 38\n\t\t\t\t\t89 .\n\t\t\t'},{id:"B15",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBould\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPanicker\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKessler\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDurant\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLewis\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDayan\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEvans\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2011 Investigation of thyroid dysfunction in general practice is more likely in patients with high psychological morbidity. Family Practice (September 2011) [Epub ahead of print]\n\t\t\t'},{id:"B16",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBradley\n\t\t\t\t\t\t\tD. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTowle\n\t\t\t\t\t\t\tH. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYoung\n\t\t\t\t\t\t\tW. S.\n\t\t\t\t\t\t\n\t\t\t\t\t 3 (1992). Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous system.\n\t\t\t\t\tJournal of Neurosciences, 12\n\t\t\t\t\t6 June 1992), 2288\n\t\t\t\t\t2302 .\n\t\t\t'},{id:"B17",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBradley\n\t\t\t\t\t\t\tD. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYoung\n\t\t\t\t\t\t\tW. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWeinberger\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t 3 &, (1989). Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary.\n\t\t\t\t\tProceedings of National Academy of Sciences U S A, 86\n\t\t\t\t\t18 September 1989), 7250\n\t\t\t\t\t7254 .\n\t\t\t'},{id:"B18",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBreteler\n\t\t\t\t\t\t\tM. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tThe association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe.\n\t\t\t\t\tJournal of Clinical Endocrinology and Metabolism, 92 N 2, (February 2007), 636\n\t\t\t\t\t640 .\n\t\t\t'},{id:"B19",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrody\n\t\t\t\t\t\t\tA. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSaxena\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSilverman\n\t\t\t\t\t\t\tD. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAlborzian\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFairbanks\n\t\t\t\t\t\t\tL. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPhelps\n\t\t\t\t\t\t\tM. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHuang\n\t\t\t\t\t\t\tS. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWu\n\t\t\t\t\t\t\tH. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaidment\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaxter\n\t\t\t\t\t\t\tL. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJr \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1999\n\t\t\t\t\tBrain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine.\n\t\t\t\t\tPsychiatry Research, (October 1999), 91 N .3 91, 127\n\t\t\t\t\t139 .\n\t\t\t'},{id:"B20",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrouwer\n\t\t\t\t\t\t\tJ. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAppelhof\n\t\t\t\t\t\t\tB. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHoogendijk\n\t\t\t\t\t\t\tW. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHuyser\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEndert\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZuketto\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchene\n\t\t\t\t\t\t\tA. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTijssen\n\t\t\t\t\t\t\tJ. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVan Dyck\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWiersinga\n\t\t\t\t\t\t\tW. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFliers\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005\n\t\t\t\t\tThyroid and adrenal axis in major depression: a controlled study in outpatients. European Journal of Endocrinology, 152\n\t\t\t\t\t152 N 2, (February 2005) 185\n\t\t\t\t\t191 .\n\t\t\t'},{id:"B21",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrouwer\n\t\t\t\t\t\t\tJ. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAppelhof\n\t\t\t\t\t\t\tB. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeeters\n\t\t\t\t\t\t\tR. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHoogendijk\n\t\t\t\t\t\t\tW. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHuyser\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchene\n\t\t\t\t\t\t\tA. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTijssen\n\t\t\t\t\t\t\tJ. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVan Dyck\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVisser\n\t\t\t\t\t\t\tT. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWiersinga\n\t\t\t\t\t\t\tW. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFliers\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2006\n\t\t\t\t\tThyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression.\n\t\t\t\t\tEuropean Journal of Endocrinology, 154\n\t\t\t\t\t6 June 2006), 819\n\t\t\t\t\t825 .\n\t\t\t'},{id:"B22",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrühl\n\t\t\t\t\t\t\tA. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJäncke\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHerwig\n\t\t\t\t\t\t\tU.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2011\n\t\t\t\t\tDifferential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants. Psychopharmacology (Berlin), (August 2011), 216 N 3, 389\n\t\t\t\t\t399 .\n\t\t\t'},{id:"B23",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBuchsbaum\n\t\t\t\t\t\t\tM. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWu\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSiegel\n\t\t\t\t\t\t\tB. V.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHackett\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTrenary\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAbel\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tReynolds\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1997\n\t\t\t\t\tEffect of sertraline on regional metabolic rate in patients with affective disorder.\n\t\t\t\t\tBiological Psychiatry, 41 N 1. (January 1997), 15\n\t\t\t\t\t22 .\n\t\t\t'},{id:"B24",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tButler\n\t\t\t\t\t\t\tP. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSmith\n\t\t\t\t\t\t\tS. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLinderman\n\t\t\t\t\t\t\tJ. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrychta\n\t\t\t\t\t\t\tR. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAlberobello\n\t\t\t\t\t\t\tA. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDubaz\n\t\t\t\t\t\t\tO. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLuzon\n\t\t\t\t\t\t\tJ. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSkarulis\n\t\t\t\t\t\t\tM. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCochran\n\t\t\t\t\t\t\tC. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWesley\n\t\t\t\t\t\t\tR. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPucino\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCeli\n\t\t\t\t\t\t\tF. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2010\n\t\t\t\t\tThe Thr92Ala 5’ type 2 deiodinase gene polymorphism is associated with a delayed triiodothyronine secretion in response to the thyrotropin-releasing hormone-stimulation test: a pharmacogenomic study. Thyroid, 20\n\t\t\t\t\t12 December 2010), 1407\n\t\t\t\t\t1412 .\n\t\t\t'},{id:"B25",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCampos-Barros\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMeinhold\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKohler\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMuller\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEravci\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaumgartner\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1995\n\t\t\t\t\tThe effects of desipramine on thyroid hormone concentrations in rat brain. Naunyn Schmiedebergs Archives of Pharmacology,\n\t\t\t\t\t351 N 5, (May 1995), 469\n\t\t\t\t\t474 .\n\t\t\t'},{id:"B26",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCanani\n\t\t\t\t\t\t\tL. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCapp\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDora\n\t\t\t\t\t\t\tJ. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMeyer\n\t\t\t\t\t\t\tE. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWagner\n\t\t\t\t\t\t\tM. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHarney\n\t\t\t\t\t\t\tJ. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLarsen\n\t\t\t\t\t\t\tP. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGross\n\t\t\t\t\t\t\tJ. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBianco\n\t\t\t\t\t\t\tA. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaia\n\t\t\t\t\t\t\tA. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005\n\t\t\t\t\tThe type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.\n\t\t\t\t\tJournal of Clinical Endocrinology and Metabolism, 90 N 6, (June 2005). 3472\n\t\t\t\t\t3478 .\n\t\t\t'},{id:"B27",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCarey\n\t\t\t\t\t\t\tP. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWarwick\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNiehaus\n\t\t\t\t\t\t\tD. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan der Linden\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Heerden\n\t\t\t\t\t\t\tB. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHarvey\n\t\t\t\t\t\t\tB. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeedat\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStein\n\t\t\t\t\t\t\tD. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2004\n\t\t\t\t\tSingle photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram.\n\t\t\t\t\tBMC Psychiatry, (October 2004) 14;4:30 EOF .\n\t\t\t'},{id:"B28",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tQ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhang\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTian\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2011\n\t\t\t\t\tMolecular imaging in patients with mood disorders: a review of PET findings. European Journal of Nuclear Medicine and Molecular Imaging, 38 N 7, (July 2011), 1367\n\t\t\t\t\t1380\n\t\t\t\t\n\t\t\t'},{id:"B29",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tConstant\n\t\t\t\t\t\t\tE. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAdam\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeron\n\t\t\t\t\t\t\tX.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBruyer\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeghers\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDaumerie\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005\n\t\t\t\t\tAnxiety and depression, attention, and executive functions in hypothyroidism, Journal of the International Neuropsychological Society, (2005), 11 N 5, (September 2005), 535\n\t\t\t\t\t544 .\n\t\t\t'},{id:"B30",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tConstant\n\t\t\t\t\t\t\tE. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Volder\n\t\t\t\t\t\t\tA. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIvanoiu\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBol\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLabar\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeghers\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCosnard\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMelin\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDaumerie\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2001\n\t\t\t\t\tCerebral blood flow and glucose metabolism in hypothyroidism: a positron emission tomography study.\n\t\t\t\t\tJournal of Clinical Endocrinology and Metabolism, 86 N 8, (August 2001), 3864\n\t\t\t\t\t3870 .\n\t\t\t'},{id:"B31",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCooper-Kazaz\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tApter\n\t\t\t\t\t\t\tJ. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCohen\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKaragichev\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMuhammed-Moussa\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGrupper\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDrori\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNewman\n\t\t\t\t\t\t\tM. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSackeim\n\t\t\t\t\t\t\tH. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGlaser\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLerer\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tCombined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial.\n\t\t\t\t\tArchives of General Psychiatry, 64 N 6, (June 2007), 679\n\t\t\t\t\t688 .\n\t\t\t'},{id:"B32",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCooper-Kazaz\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan der Deure\n\t\t\t\t\t\t\tW. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMedici\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVisser\n\t\t\t\t\t\t\tT. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAlkelai\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGlaser\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeeters\n\t\t\t\t\t\t\tR. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLerer\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2009\n\t\t\t\t\tPreliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine. Journal of Affective Disorders, (July 2009), 116 N 1-2, 113\n\t\t\t\t\t116 .\n\t\t\t'},{id:"B33",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCooper-Kazaz\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLerer\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2008\n\t\t\t\t\tEfficacy and safety of triiodothyronine supplementation in patients with major depressive disorder treated with specific serotonin reuptake inhibitors. International Journal of Neuropsychopharmacology, 11 N 5, (August 2008), 685\n\t\t\t\t\t699 .\n\t\t\t'},{id:"B34",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCoppen\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWhyborw\n\t\t\t\t\t\t\tP. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNoguera\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaggs\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrange Jr\n\t\t\t\t\t\t\tA. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1972\n\t\t\t\t\tThe comparative antidepressant value of L-tryptophan and imipramine with and without attempted potentiation by liothyronine.\n\t\t\t\t\tArchives of General Psychiatry, 26\n\t\t\t\t\t3 March 1972), 234\n\t\t\t\t\t241 .\n\t\t\t'},{id:"B35",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCoppotelli\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSummers\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChidakel\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRoss\n\t\t\t\t\t\t\tJ. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCeli\n\t\t\t\t\t\t\tF. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2006\n\t\t\t\t\tFunctional characterization of the 258 A/G (D2-ORFa-Gly3Asp) human type-2 deiodinase polymorphism: a naturally occurring variant increases the enzymatic activity by removing a putative repressor site in the 5’ UTR of the gene. Thyroid, (July 2006),16 N 7, 625\n\t\t\t\t\t632 .\n\t\t\t'},{id:"B36",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCrantz\n\t\t\t\t\t\t\tF. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSilva\n\t\t\t\t\t\t\tJ. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLarsen\n\t\t\t\t\t\t\tP. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1982\n\t\t\t\t\tAn analysis of the sources and quantity of 3,5,3’-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum.\n\t\t\t\t\tEndocrinology, 110 N 2, (February 1982) 367\n\t\t\t\t\t375 .\n\t\t\t'},{id:"B37",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Jong\n\t\t\t\t\t\t\tF. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeeters\n\t\t\t\t\t\t\tR. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tden\n\t\t\t\t\t\t\tHeijer. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan der Deure\n\t\t\t\t\t\t\tW. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHofman\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUitterlinden\n\t\t\t\t\t\t\tA. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVisser\n\t\t\t\t\t\t\tT. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\tT. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBreteler\n\t\t\t\t\t\t\tM. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007 The association of polimorphisms in the type 1 and 2 deidinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe. Journal of Clinical Endocrinology and Metabolism, 2 February 2007), 636\n\t\t\t\t\t640 .\n\t\t\t'},{id:"B38",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDratman\n\t\t\t\t\t\t\tM. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGordon\n\t\t\t\t\t\t\tJ. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1996\n\t\t\t\t\tThyroid hormones as neurotransmitters. DratmanM. B.GordonJ. T. (1996). Thyroid hormones as neurotransmitters. Thyroid, Vol.6; N 6 (December 1996) pp.639-647., 6 N 6 (December 1996) 639\n\t\t\t\t\t647 .\n\t\t\t'},{id:"B39",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDussault\n\t\t\t\t\t\t\tJ. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRuel\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1987\n\t\t\t\t\tThyroid hormones and brain development.\n\t\t\t\t\tAnnual Review of Physiology, 49\n\t\t\t\t\t3 March 1987), 321\n\t\t\t\t\t334 .\n\t\t\t'},{id:"B40",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEl -Bakry\n\t\t\t\t\t\t\tA. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEl -Gareib\n\t\t\t\t\t\t\tA. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAhmed\n\t\t\t\t\t\t\tR. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2010\n\t\t\t\t\tComparative study of the effects of experimentally induced hypothyroidism and hyperthyroidism in some brain regions in albino rats. Journal of Developmental Neuroscience, 28\n\t\t\t\t\t5 August 2010), 371\n\t\t\t\t\t389 .\n\t\t\t'},{id:"B41",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEmerson\n\t\t\t\t\t\t\tC. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDyson\n\t\t\t\t\t\t\tW. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUtiger\n\t\t\t\t\t\t\tR. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1973\n\t\t\t\t\tSerum thyrotropin and thyroxine concentrations in patients receiving lithium carbonate. Journal of Clinical Endocrinology and Metabolism, 36\n\t\t\t\t\t2 February 1972), 338\n\t\t\t\t\t346 .\n\t\t\t'},{id:"B42",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEravci\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPinna\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMeinhold\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaumgartner\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2000\n\t\t\t\t\tEffects of pharmacological and nonpharmacological treatments on thyroid hormone metabolism and concentrations in rat brain.\n\t\t\t\t\tEndocrinology, 141 N 3, (March 2000) 1027\n\t\t\t\t\t1040 .\n\t\t\t'},{id:"B43",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFarwell\n\t\t\t\t\t\t\tA. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDubord\n\t\t\t\t\t\t\tS. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1996 Thyroid hormone regulates neurite outgrowth and neuronal migration onto laminin. Thyroid,\n\t\t\t\t\t6 (Suppl 1) (1996) pp.S-6\n\t\t\t'},{id:"B44",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFarwell\n\t\t\t\t\t\t\tA. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDubord-Tomasetti\n\t\t\t\t\t\t\tS. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPietrzykowski\n\t\t\t\t\t\t\tA. Z.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLeonard\n\t\t\t\t\t\t\tJ. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2006\n\t\t\t\t\tDynamic nongenomic actions of thyroid hormone in the developing rat brain.\n\t\t\t\t\tEndocrinology, 147\n\t\t\t\t\t5 May 2006), 2567\n\t\t\t\t\t2574 .\n\t\t\t'},{id:"B45",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tForman-Hoffman\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPhilibert\n\t\t\t\t\t\t\tR. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2006\n\t\t\t\t\tLower TSH and higher T4 levels are associated with current depressive syndrome in young adults. Acta Psychiatrica Scandinava, 114 N 2, (August 2006) 132\n\t\t\t\t\t139\n\t\t\t\t\n\t\t\t'},{id:"B46",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tForrest\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tErway\n\t\t\t\t\t\t\tL. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNg\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAltschuler\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCurran\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1996a\n\t\t\t\t\tThyroid hormone receptor beta is essential for development of auditory function.\n\t\t\t\t\tNature Genetics, 13\n\t\t\t\t\t3 July 1996), 354\n\t\t\t\t\t357 .\n\t\t\t'},{id:"B47",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tForrest\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHanebuth\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSmeyne\n\t\t\t\t\t\t\tR. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEverds\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStewart\n\t\t\t\t\t\t\tC. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWehner\n\t\t\t\t\t\t\tJ. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCurran\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1996b\n\t\t\t\t\tRecessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.\n\t\t\t\t\tThe EMBO Journal, 15\n\t\t\t\t\t12 June 1996), 3006\n\t\t\t\t\t3015 .\n\t\t\t'},{id:"B48",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFountoulakis\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKantartzis\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSiamouli\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPanagiotidis\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKaprinis\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIacovides\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKaprinis\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2006\n\t\t\t\t\tPeripheral thyroid dysfunction in depression. The World Journal of Biological Psychiatry, 7 N 3, (2006), 131\n\t\t\t\t\t137 .\n\t\t\t'},{id:"B49",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFraichard\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChassande\n\t\t\t\t\t\t\tO.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPlateroti\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRoux\n\t\t\t\t\t\t\tJ. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTrouillas\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDehay\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLegrand\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGauthier\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKedinger\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMalaval\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRousset\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSamarut\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1997\n\t\t\t\t\tThe T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production.\n\t\t\t\t\tThe EMBO Journal, 16\n\t\t\t\t\t14 July 1997), 4412\n\t\t\t\t\t4420 .\n\t\t\t'},{id:"B50",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGereben\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZavacki\n\t\t\t\t\t\t\tA. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRibich\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKim\n\t\t\t\t\t\t\tB. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHuang\n\t\t\t\t\t\t\tS. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSimonides\n\t\t\t\t\t\t\tW. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZeold\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBianco\n\t\t\t\t\t\t\tA. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2008a\n\t\t\t\t\tCellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocrinology Review\n\t\t\t\t\t29 N 7, (December 2008) 898\n\t\t\t\t\t938 .\n\t\t\t'},{id:"B51",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGereben\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZeöld\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDentice\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSalvatore\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBianco\n\t\t\t\t\t\t\tA. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2008b\n\t\t\t\t\tActivation and inactivation of thyroid hormone by deiodinases: local action with general consequences. Cellular and Molecular Life Sciences, 65 N 4, (February 2008), 570\n\t\t\t\t\t590 .\n\t\t\t'},{id:"B52",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGerner\n\t\t\t\t\t\t\tR. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYamada\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1982\n\t\t\t\t\tAltered neuropeptide concentrations in cerebrospinal fluid of psychiatric patients.\n\t\t\t\t\tBrain Research, 238\n\t\t\t\t\t1 April 1982), 298\n\t\t\t\t\t302 .\n\t\t\t'},{id:"B53",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGhenimi\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAlfos\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRedonnet\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHigueret\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPallet\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEnderlin\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2010\n\t\t\t\t\tAdult-onset hypothyroidism induces the amyloidogenic pathway of amyloid precursor protein processing in the rat hippocampus. Journal of Neuroendocrinology, 22\n\t\t\t\t\t8 August 2010), 951\n\t\t\t\t\t959 .\n\t\t\t'},{id:"B54",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGhosh\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDas\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007 Increased beta(2)-adrenergic receptor activity by thyroid hormone possibly leads to differentiation and maturation of astrocytes in culture. Cellular and Molecular Neurobiology, 27 N 8, (December 2007), 1007\n\t\t\t\t\t1021 .\n\t\t\t'},{id:"B55",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGöthe\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWang\n\t\t\t\t\t\t\tZ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNg\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKindblom\n\t\t\t\t\t\t\tJ. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBarros\n\t\t\t\t\t\t\tA. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOhlsson\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVennström\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tForrest\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1999\n\t\t\t\t\tMice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.\n\t\t\t\t\tGenes & Development, 13\n\t\t\t\t\t10 May 1999), 1329\n\t\t\t\t\t1341 .\n\t\t\t'},{id:"B56",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGouveia\n\t\t\t\t\t\t\tC. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChristoffolete\n\t\t\t\t\t\t\tM. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZaitune\n\t\t\t\t\t\t\tC. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDora\n\t\t\t\t\t\t\tJ. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHarney\n\t\t\t\t\t\t\tJ. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaia\n\t\t\t\t\t\t\tA. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBianco\n\t\t\t\t\t\t\tA. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005\n\t\t\t\t\tType 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation.\n\t\t\t\t\tEndocrinology, 146 N .1, (January 2005), 195\n\t\t\t\t\t200 .\n\t\t\t'},{id:"B57",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHagen\n\t\t\t\t\t\t\tG. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSolberg\n\t\t\t\t\t\t\tL. A. Jr\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1974\n\t\t\t\t\tBrain and cerebrospinal fluid permeability to intravenous thyroid hormones.\n\t\t\t\t\tEndocrinology, 95 N .5, (November 1974), 1398\n\t\t\t\t\t1410 .\n\t\t\t'},{id:"B58",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHansen\n\t\t\t\t\t\t\tP. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan der Deure\n\t\t\t\t\t\t\tW. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeeters\n\t\t\t\t\t\t\tR. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIachine\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFenger\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSorensen\n\t\t\t\t\t\t\tT. I.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKyvik\n\t\t\t\t\t\t\tK. O.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVisser\n\t\t\t\t\t\t\tT. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHegedus\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tThe impact of a TSH receptor gene polymorphism on thyroid-related phenotypes in a healthy Danish twin population. Clinical Endocrinology (Oxf), 66 N 6, (June 2007), 827\n\t\t\t\t\t832 .\n\t\t\t'},{id:"B59",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHe\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWang\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJu\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLu\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShi\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHe\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhong\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2009\n\t\t\t\t\tAssociation of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population. Progress in Neuropsychopharmacology & Biological Psychiatry, 33\n\t\t\t\t\t6 August 2009), 986\n\t\t\t\t\t990 .\n\t\t\t'},{id:"B60",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHeal\n\t\t\t\t\t\t\tD. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSmith\n\t\t\t\t\t\t\tS. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1988\n\t\t\t\t\tThe effects of acute and repeated administration of T3 to mice on 5-HT1 and 5-HT2 function in the brain and its influence on the actions of repeated electroconvulsive shock.\n\t\t\t\t\tNeuropharmacology, 27 N .12, (December 1988), 1239\n\t\t\t\t\t1248 .\n\t\t\t'},{id:"B61",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIosifescu\n\t\t\t\t\t\t\tD. V.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAA\n\t\t\t\t\t\t\tNierenberg\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMischoulon\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPerlis\n\t\t\t\t\t\t\tR. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPapakostas\n\t\t\t\t\t\t\tG. I.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRyan\n\t\t\t\t\t\t\tJ. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAlpert\n\t\t\t\t\t\t\tJ. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFava\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005\n\t\t\t\t\tAn open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder.\n\t\t\t\t\tJournal of Clinical Psychiatry, 66\n\t\t\t\t\t8 August 2005), 1038\n\t\t\t\t\t1042 .\n\t\t\t'},{id:"B62",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJärnum\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEskildsen\n\t\t\t\t\t\t\tS. F.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSteffensen\n\t\t\t\t\t\t\tE. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLundbye-Christensen\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSimonsen\n\t\t\t\t\t\t\tC. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tThomsen\n\t\t\t\t\t\t\tI. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFründ\n\t\t\t\t\t\t\tE. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tThéberge\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLarsson\n\t\t\t\t\t\t\tE. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2011\n\t\t\t\t\tLongitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder.\n\t\t\t\t\tActa Psychiatrica Scandinavica, (September 2011)16. doi: 10.1111/j.1600\n\t\t\t\t\t0447 .2011.01766.x. [Epub ahead of print]\n\t\t\t'},{id:"B63",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJoffe\n\t\t\t\t\t\t\tR. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSinger\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1990 A comparison of triiodotironine and thyroxine in the potentiation of tricyclic antidepressants. Psychiatry Research, 32\n\t\t\t\t\t3 June 1990), 241\n\t\t\t\t\t251 .\n\t\t\t'},{id:"B64",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJones\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNg\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tForrest\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tAn intron control region differentially regulates expression of thyroid hormone receptor beta2 in the cochlea, pituitary, and cone photoreceptors.\n\t\t\t\t\tMolecular Endocrinology, 21\n\t\t\t\t\t5 May 2007), 1108\n\t\t\t\t\t1119 .\n\t\t\t'},{id:"B65",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKennedy\n\t\t\t\t\t\t\tS. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKonarski\n\t\t\t\t\t\t\tJ. Z.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSegal\n\t\t\t\t\t\t\tZ. V.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLau\n\t\t\t\t\t\t\tM. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBieling\n\t\t\t\t\t\t\tP. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMc Intyre\n\t\t\t\t\t\t\tR. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMayberg\n\t\t\t\t\t\t\tH. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tDifferences in brain glucose metabolism between responders to CBT and Venlafaxine in a 16-week randomized controlled trial. American Journal of Psychiatry, 164 N 5. (May 2007), 778\n\t\t\t\t\t788\n\t\t\t\t\n\t\t\t'},{id:"B66",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKirkegaard\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFaber\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1998\n\t\t\t\t\tThe role of thyroid hormones in depression. European Journal of Endocrinology, (January1998), 138 N 1, 1\n\t\t\t\t\t9 .\n\t\t\t'},{id:"B67",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKohn\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFreedman\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLester\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKrausz\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChisin\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLerer\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBonne\n\t\t\t\t\t\t\tO.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\t99mTc-HMPAO SPECT study of cerebral perfusion after treatment with medication and electroconvulsive therapy in major depression. Journal of Nuclear Medicine, 48 N 8, (August 2007) 1273\n\t\t\t\t\t1278\n\t\t\t\t\n\t\t\t'},{id:"B68",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLarsen\n\t\t\t\t\t\t\tJ. K.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFaber\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChristensen\n\t\t\t\t\t\t\tE. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBendsen\n\t\t\t\t\t\t\tB. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSolstad\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGjerris\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSiersbaek-Nielsen\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2004\n\t\t\t\t\tRelationship between mood and TSH response to TRH stimulation in bipolar affective disorder.\n\t\t\t\t\tPsychoneuroendocrinology, 29\n\t\t\t\t\t7 August 2004), 917\n\t\t\t\t\t924 .\n\t\t\t'},{id:"B69",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLeonard\n\t\t\t\t\t\t\tJ. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFarwell\n\t\t\t\t\t\t\tA. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1997\n\t\t\t\t\tThyroid hormone-regulated actin polymerization in brain. LeonardJ. L.FarwellA. P. (1997). Thyroid hormone-regulated actin polymerization in brain. Thyroid, Vol.7, No.1 (February 1997), pp. 147-151. , 7\n\t\t\t\t\t1 February 1997), 147\n\t\t\t\t\t151 .\n\t\t\t'},{id:"B70",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLifschytz\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSegman\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShalom\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLerer\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGur\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGolzer\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNewman\n\t\t\t\t\t\t\tM. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2006\n\t\t\t\t\tBasic mechanisms of augmentation of antidepressant effects with thyroid hormone.\n\t\t\t\t\tCurrent Drug Targets, 7 N 2, (February 2006), 203\n\t\t\t\t\t210 .\n\t\t\t'},{id:"B71",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLinkowski\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrauman\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMendlewicz\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1981\n\t\t\t\t\tThyrotrophin response to thyrotrophin-releasing hormone in unipolar and bipolar affective illness.\n\t\t\t\t\tJournal of Affective Disorders, 3\n\t\t\t\t\t1 March 1981), 9\n\t\t\t\t\t16 .\n\t\t\t'},{id:"B72",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tŁojko\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRybakowski\n\t\t\t\t\t\t\tJ. K.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tL-thyroxine augmentation of serotonergic antidepressants in female patients with refractory depression. Journal of Affective Disorders, 103\n\t\t\t\t\t1-3 (November 2007), 253\n\t\t\t\t\t256 .\n\t\t\t'},{id:"B73",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLoosen\n\t\t\t\t\t\t\tP. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1985\n\t\t\t\t\tThe TRH-induced TSH response in psychiatric patients: a possible neuroendocrine marker.\n\t\t\t\t\tPsychoneuroendocrinology, 10\n\t\t\t\t\t3\n\t\t\t\t\t237\n\t\t\t\t\t260 .\n\t\t\t'},{id:"B74",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMac\n\t\t\t\t\t\t\tQueen. G. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2009\n\t\t\t\t\tMagnetic resonance imaging and prediction of outcome in patients with major depressive disorder. Journal of Psychiatry & Neurosciences, 34 N 5, (September 2009) 343\n\t\t\t\t\t349 .\n\t\t\t'},{id:"B75",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarangell\n\t\t\t\t\t\t\tL. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKetter\n\t\t\t\t\t\t\tT. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGeorge\n\t\t\t\t\t\t\tM. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPazzaglia\n\t\t\t\t\t\t\tP. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCallahan\n\t\t\t\t\t\t\tA. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tParekh\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAndreason\n\t\t\t\t\t\t\tP. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHorwitz\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHerscovitch\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPost\n\t\t\t\t\t\t\tR. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1997\n\t\t\t\t\tInverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders. American Journal of Psychiatry, 154 N 2, (February 1997), 224\n\t\t\t\t\t230 ,\n\t\t\t'},{id:"B76",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMentuccia\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tProietti-Pannunzi\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTanner\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBacci\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPollin\n\t\t\t\t\t\t\tT. I.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPoehlman\n\t\t\t\t\t\t\tE. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShuldiner\n\t\t\t\t\t\t\tA. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCeli\n\t\t\t\t\t\t\tF. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002\n\t\t\t\t\tAssociation between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor.\n\t\t\t\t\tDiabetes, 51 N 3, (March 2002), 880\n\t\t\t\t\t883 .\n\t\t\t'},{id:"B77",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMilak\n\t\t\t\t\t\t\tM. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tParsey\n\t\t\t\t\t\t\tR. V.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKeilp\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOquendo\n\t\t\t\t\t\t\tM. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMalone\n\t\t\t\t\t\t\tK. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMann\n\t\t\t\t\t\t\tJ. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005\n\t\t\t\t\tNeuroanatomic correlates of psychopathologic components of major depressive disorder.\n\t\t\t\t\tArchives of General Psychiatry, 62 N 4, (April 2005), 397\n\t\t\t\t\t408 ,\n\t\t\t'},{id:"B78",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMiller\n\t\t\t\t\t\t\tK. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tParsons\n\t\t\t\t\t\t\tT. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWhybrow\n\t\t\t\t\t\t\tP. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVan Herle\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRasgon\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVan Herle\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMartinez\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSilverman\n\t\t\t\t\t\t\tD. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBauer\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tVerbal memory retrieval deficits associated with untreated hypothyroidism. Journal of Neuropsychiatry and Clinical Neurosciences, 19 N 2, (2007), 132\n\t\t\t\t\t136 .\n\t\t\t'},{id:"B79",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMorte\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDiez\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAuso\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBelinchon\n\t\t\t\t\t\t\tM. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGil-Ibanez\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGrijota-Martinez\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNavarro\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Escobar\n\t\t\t\t\t\t\tG. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBerbel\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBernal\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2010\n\t\t\t\t\tThyroid hormone regulation of gene expression in the developing rat fetal cerebral cortex: prominent role of the Ca2+/calmodulin-dependent protein kinase IV pathway.\n\t\t\t\t\tEndocrinology, 151 N 2, (February 2010), 810\n\t\t\t\t\t820 .\n\t\t\t'},{id:"B80",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMowla\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKalantarhormozi\n\t\t\t\t\t\t\tM. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKhazraee\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2011\n\t\t\t\t\tClinical characteristics of patients with major depressive disorder with and without hypothyroidism: A comparative study. Journal of Psychiatric Practice, (January 2011), 17 N 1, 67\n\t\t\t\t\t71 .\n\t\t\t'},{id:"B81",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMyers\n\t\t\t\t\t\t\tD. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCarter\n\t\t\t\t\t\t\tR. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBurns\n\t\t\t\t\t\t\tB. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tArmond\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHussain\n\t\t\t\t\t\t\tS. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChengapa\n\t\t\t\t\t\t\tV. K.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1985\n\t\t\t\t\tA prospective study of the effects of lithium on thyroid function and on the prevalence of antithyroid antibodies.\n\t\t\t\t\tPsychological Medicine, 15\n\t\t\t\t\t1 February 1985), 55\n\t\t\t\t\t61 .\n\t\t\t'},{id:"B82",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNagamachi\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJinnouchi\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNishii\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIshida\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFujita\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFutami\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKodama\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTamura\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKawai\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2004\n\t\t\t\t\tCerebral blood flow abnormalities induced by transient hypothyroidism after thyroidectomy-analysis by tc-99m-HMPAO and SPM96.\n\t\t\t\t\tAnnals of Nuclear Medicine, 18 N 6, (September 2004), 469\n\t\t\t\t\t477 .\n\t\t\t'},{id:"B83",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNavarro\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGasto\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLomena\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMateos\n\t\t\t\t\t\t\tJ. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPortella\n\t\t\t\t\t\t\tM. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMassana\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBernardo\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarcos\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2004 Frontal cerebral perfusion after antidepressant drug treatment versus ECT in elderly patients with major depression: a 12-month follow-up control study Journal of Clinical Psychiatry,\n\t\t\t\t\t65 N 5, (May 2004), 656\n\t\t\t\t\t661 .\n\t\t\t'},{id:"B84",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeeters\n\t\t\t\t\t\t\tR. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan den\n\t\t\t\t\t\t\tBeld. A. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAttalki\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tToor\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Rijke\n\t\t\t\t\t\t\tY. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKuiper\n\t\t\t\t\t\t\tG. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLamberts\n\t\t\t\t\t\t\tS. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJanssen\n\t\t\t\t\t\t\tJ. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUitterlinden\n\t\t\t\t\t\t\tA. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVisser\n\t\t\t\t\t\t\tT. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005\n\t\t\t\t\tA new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters.\n\t\t\t\t\tAmerican Journal of Physiology, Endocrinology and Metabolism, 289 N 1, (July 2005), E75\n\t\t\t\t\tE81 .\n\t\t\t'},{id:"B85",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeeters\n\t\t\t\t\t\t\tR. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan der Deure\n\t\t\t\t\t\t\tW. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan den\n\t\t\t\t\t\t\tBeld. A. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Toor\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLamberts\n\t\t\t\t\t\t\tS. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJanssen\n\t\t\t\t\t\t\tJ. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUitterlinden\n\t\t\t\t\t\t\tA. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVisser\n\t\t\t\t\t\t\tT. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tThe Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Clinical Endocrinology (Oxf), 66 N 6, (June 2007), 808\n\t\t\t\t\t815 .\n\t\t\t'},{id:"B86",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeeters\n\t\t\t\t\t\t\tR. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan der Deure\n\t\t\t\t\t\t\tW. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVisser\n\t\t\t\t\t\t\tT. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2006\n\t\t\t\t\tGenetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinases. European Journal of Endocrinology\n\t\t\t\t\t155 N 5, (November 2006), 655\n\t\t\t\t\t662 .\n\t\t\t'},{id:"B87",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeeters\n\t\t\t\t\t\t\tR. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Toor\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKlootwijk\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Rijke\n\t\t\t\t\t\t\tY. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKuiper\n\t\t\t\t\t\t\tG. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUitterlinden\n\t\t\t\t\t\t\tA. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVisser\n\t\t\t\t\t\t\tT. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2003\n\t\t\t\t\tPolymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects.\n\t\t\t\t\tJournal of Clinical Endocrinology and Metabolism, 88 N 6, (June 2003), 2880\n\t\t\t\t\t2888 .\n\t\t\t'},{id:"B88",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrange Jr\n\t\t\t\t\t\t\tA. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWilson\n\t\t\t\t\t\t\tI. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRabon\n\t\t\t\t\t\t\tA. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLipton\n\t\t\t\t\t\t\tM.A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1969 Enhancement of imipramine antidepressant activity by thyroid hormone. American Journal of Psychiatry, 126\n\t\t\t\t\t4 October 1969), 457\n\t\t\t\t\t469 .\n\t\t\t'},{id:"B89",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRichieri\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBoyer\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFarisse\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tColavolpe\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMundler\n\t\t\t\t\t\t\tO.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLancon\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGuedj\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2011\n\t\t\t\t\tPredictive value of brain perfusion SPECT for rTMS response in pharmacoresistant depression. European Journal of Nuclear Medicine and Molecular Imaging, 38 N 9, (September 2011), 1715\n\t\t\t\t\t1722 .\n\t\t\t'},{id:"B90",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRisco\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGonzález\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGaray\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tArancibia\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNuñez\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHasler\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGalleguillos\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2003 Evaluación funcional del eje hipotálamo-hipófisis-tiroides en episodio depresivo mayor único: ¿desregulación a nivel central?. Revista de Neuro-Psiquiatría, 66 N .4, (2003), 320\n\t\t\t\t\t328 .\n\t\t\t'},{id:"B91",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRoy-Byrne\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPost\n\t\t\t\t\t\t\tR. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRubinow\n\t\t\t\t\t\t\tD. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLinnoila\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSavard\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavis\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1983\n\t\t\t\t\tCSF 5HIAA and personal and family history of suicide in affectively ill patients: a negative study.\n\t\t\t\t\tPsychiatry Research, 10\n\t\t\t\t\t4 December 1983), 263\n\t\t\t\t\t274 .\n\t\t\t'},{id:"B92",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRozanov\n\t\t\t\t\t\t\tC. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDratman\n\t\t\t\t\t\t\tM. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1996\n\t\t\t\t\tImmunohistochemical mapping of brain triiodothyronine reveals prominent localization in central noradrenergic systems. Neuroscience, 74 N 3 (October, 1996), 897\n\t\t\t\t\t915 .\n\t\t\t'},{id:"B93",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRubinow\n\t\t\t\t\t\t\tD. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGold\n\t\t\t\t\t\t\tP. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPost\n\t\t\t\t\t\t\tR. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBallenger\n\t\t\t\t\t\t\tJ. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCowdry\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBollinger\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tReichlin\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1983\n\t\t\t\t\tCSF somatostatin in affective illness.\n\t\t\t\t\tArchives of General Psychiatry, 40\n\t\t\t\t\t4 April 1983), 377\n\t\t\t\t\t386 .\n\t\t\t'},{id:"B94",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRuhé\n\t\t\t\t\t\t\tH. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBooij\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVeltman\n\t\t\t\t\t\t\tD. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMichel\n\t\t\t\t\t\t\tM. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchene\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2011 Successful pharmacologic treatment of major depressive disorder attenuates amygdala activation to negative facial expressions: a functional magnetic resonance imaging study. Journal of Clinical Psychiatry, (August 2011), [Epub ahead of print]\n\t\t\t'},{id:"B95",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSamuels\n\t\t\t\t\t\t\tM. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchuff\n\t\t\t\t\t\t\tK. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCarlson\n\t\t\t\t\t\t\tN. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCarello\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJanowsky\n\t\t\t\t\t\t\tJ. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007\n\t\t\t\t\tHealth status, mood, and cognition in experimentally induced subclinical hypothyroidism.\n\t\t\t\t\tJournal of Clinical Endocrinology and Metabolism,\n\t\t\t\t\t92 N 7, (2007), 2545\n\t\t\t\t\t2551 .\n\t\t\t'},{id:"B96",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSaxena\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSingh\n\t\t\t\t\t\t\tP. N.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSrivastava\n\t\t\t\t\t\t\tU.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSiddiqui\n\t\t\t\t\t\t\tA. Q.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2000 A study of thyroid hormones (T3, T4 & TSH) in patients of depression. Indian Journal of Psychiatry,\n\t\t\t\t\t42 N 3, (July 2000) 243\n\t\t\t\t\t246 .\n\t\t\t'},{id:"B97",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSinghal\n\t\t\t\t\t\t\tR. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRastogi\n\t\t\t\t\t\t\tR. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHrdina\n\t\t\t\t\t\t\tP. D.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1975\n\t\t\t\t\tBrain biogenic amines and altered thyroid function.\n\t\t\t\t\tLife Sciences,17 N 11, (December 1975),1617\n\t\t\t\t\t1626 .\n\t\t\t'},{id:"B98",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSmith\n\t\t\t\t\t\t\tJ. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEvans\n\t\t\t\t\t\t\tA. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCostall\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSmythe\n\t\t\t\t\t\t\tJ. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002 Thyroid hormones, brain function and cognition: a brief review. Neurosciences and Biobehavioral Reviews,\n\t\t\t\t\t26 N 1, (January 2002), 45\n\t\t\t\t\t60 .\n\t\t\t'},{id:"B99",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStern\n\t\t\t\t\t\t\tR. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNevels\n\t\t\t\t\t\t\tC. T.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShelhorse\n\t\t\t\t\t\t\tM.E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tProhaska\n\t\t\t\t\t\t\tM. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMason\n\t\t\t\t\t\t\tG. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrange \n\t\t\t\t\t\t\tA. J. Jr\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1991\n\t\t\t\t\tAntidepressant and memory effects of combined thyroid hormone treatment and electroconvulsive therapy: Preliminary findings.\n\t\t\t\t\tBiological Psychiatry, 30\n\t\t\t\t\t6 September 1991), 623\n\t\t\t\t\t627 .\n\t\t\t'},{id:"B100",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStipcević\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPivac\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKozarić-Kovacić\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMück-Seler\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2008\n\t\t\t\t\tThyroid activity in patients with major depression.\n\t\t\t\t\tCollegium Antropologicum, 3 September 2008),973\n\t\t\t\t\t976 .\n\t\t\t'},{id:"B101",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStrawn\n\t\t\t\t\t\t\tJ. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEkhator\n\t\t\t\t\t\t\tN. N.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tD’Souza\n\t\t\t\t\t\t\tB. B.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGeracioti \n\t\t\t\t\t\t\tT. D. Jr\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2004\n\t\t\t\t\tPituitary-thyroid state correlates with central dopaminergic and serotonergic activity in healthy humans. Neuropsychobiology, 49\n\t\t\t\t\t2\n\t\t\t\t\t84\n\t\t\t\t\t87 .\n\t\t\t'},{id:"B102",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSzabadi\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1991\n\t\t\t\t\tThyroid dysfunction and affective illness.\n\t\t\t\t\tBritish Medical Journal, 302\n\t\t\t\t\t6782 April 1991), 923\n\t\t\t\t\t924 .\n\t\t\t'},{id:"B103",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTorlontano\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDurante\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTorrente\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCrocetti\n\t\t\t\t\t\t\tU.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAugello\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRonga\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMontesano\n\t\t\t\t\t\t\tT.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTravascio\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVerrienti\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBruno\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSantini\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tD’Arcangelo\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDallapiccola\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFiletti\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTrischitta\n\t\t\t\t\t\t\tV.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2008\n\t\t\t\t\tType 2 deiodinase polymorphism (threonine 92 alanine) predicts L-thyroxine dose to achieve target thyrotropin levels in thyroidectomized patients. Journal of Clinical Endocrinology and Metabolism, 93 N 3, (March 2008) 910\n\t\t\t\t\t913 .\n\t\t\t'},{id:"B104",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVlassenko\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSheline\n\t\t\t\t\t\t\tY. I.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFischer\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMintun\n\t\t\t\t\t\t\tM. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2004\n\t\t\t\t\tCerebral perfusion response to successful treatment of depression with different serotoninergic agents. Journal of Neuropsychiatry and Clinical Neurosciences, 16 N 3, (Summer 2004), 360\n\t\t\t\t\t363 .\n\t\t\t'},{id:"B105",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWalker\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWeichsel\n\t\t\t\t\t\t\tM. E. Jr\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFisher\n\t\t\t\t\t\t\tD. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGuo\n\t\t\t\t\t\t\tS. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1979\n\t\t\t\t\tThyroxine increases nerve growth factor concentration in adult mouse brain. Science, 204 N 4391, (April 1979), 427\n\t\t\t\t\t429 .\n\t\t\t'},{id:"B106",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWalker\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWeil\n\t\t\t\t\t\t\tM. L.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWeichsel\n\t\t\t\t\t\t\tM. E. Jr\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFisher\n\t\t\t\t\t\t\tD. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1981\n\t\t\t\t\tEffect of thyroxine on nerve growth factor concentration in neonatal mouse brain.\n\t\t\t\t\tLife Sciences,28 N 15-16 (April 1981), 1777\n\t\t\t\t\t1787 .\n\t\t\t'},{id:"B107",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWheatley\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1972\n\t\t\t\t\tPotentiation of amitriptyline by thyroid hormone.\n\t\t\t\t\tArchives of General Psychiatry, 26\n\t\t\t\t\t3 March 1972), 229\n\t\t\t\t\t233 .\n\t\t\t'},{id:"B108",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWhybrow\n\t\t\t\t\t\t\tP. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrange\n\t\t\t\t\t\t\tA. J. Jr\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1981\n\t\t\t\t\tA hypothesis of thyroid-catecholamine-receptor interaction. Its relevance to affective illness.\n\t\t\t\t\tArchives of General Psychiatry, 38 N 1, (1981), 106\n\t\t\t\t\t113 .\n\t\t\t'},{id:"B109",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWikström\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJohansson\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSaltó\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBarlow\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCampos\n\t\t\t\t\t\t\tBarros. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaas\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tForrest\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tThorén\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVennström\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1998\n\t\t\t\t\tAbnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1.\n\t\t\t\t\tThe EMBO Journal, 17\n\t\t\t\t\t2 January 1998), 455\n\t\t\t\t\t461 .\n\t\t\t'},{id:"B110",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWilson\n\t\t\t\t\t\t\tI. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrange Jr\n\t\t\t\t\t\t\tA. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMc Clane\n\t\t\t\t\t\t\tT. K.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRabon\n\t\t\t\t\t\t\tA. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLipton\n\t\t\t\t\t\t\tM.A.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1970 Thyroid hormone enhancement of imipramine in nonretarded depressions. New England Journal of Medicine, 282\n\t\t\t\t\t19 May 1970), 1063\n\t\t\t\t\t1067 .\n\t\t\t'},{id:"B111",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZavacki\n\t\t\t\t\t\t\tA. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYing\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChristoffolete\n\t\t\t\t\t\t\tM. A.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAerts\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSo\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHarney\n\t\t\t\t\t\t\tJ. W.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCheng\n\t\t\t\t\t\t\tS. Y.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLarsen\n\t\t\t\t\t\t\tP. R.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBianco\n\t\t\t\t\t\t\tA. C.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005\n\t\t\t\t\tType 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.\n\t\t\t\t\tEndocrinology, 146 N 3, (March 2005)1568\n\t\t\t\t\t1575 .\n\t\t\t'},{id:"B112",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZobel\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJoe\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFreymann\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tClusmann\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchramm\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tReinhardt\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBiersack\n\t\t\t\t\t\t\tH. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaier\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBroich\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005 Changes in regional cerebral blood flow by therapeutic vagus nerve stimulation in depression: An exploratory approach Psychiatry Research, 139 N 3, (August 2005), 165\n\t\t\t\t\t179 .\n\t\t\t'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"A. Verónica Araya",address:"",affiliation:'
Endocrinology Section, Clinical Hospital of the University of Chile, Chile
Endocrinology Section, Clinical Hospital of the University of Chile, Chile
'}],corrections:null},book:{id:"1258",type:"book",title:"Thyroid and Parathyroid Diseases",subtitle:"New Insights into Some Old and Some New Issues",fullTitle:"Thyroid and Parathyroid Diseases - New Insights into Some Old and Some New Issues",slug:"thyroid-and-parathyroid-diseases-new-insights-into-some-old-and-some-new-issues",publishedDate:"March 7th 2012",bookSignature:"Laura Sterian Ward",coverURL:"https://cdn.intechopen.com/books/images_new/1258.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:null,printIsbn:"978-953-51-0221-2",pdfIsbn:"978-953-51-6869-0",reviewType:"peer-reviewed",numberOfWosCitations:17,isAvailableForWebshopOrdering:!0,editors:[{id:"40956",title:"Dr.",name:"Laura",middleName:"Sterian",surname:"Ward",slug:"laura-ward",fullName:"Laura Ward"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1012"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"31300",type:"chapter",title:"\ufeffIntroduction to Thyroid: Anatomy and Functions",slug:"introduction-to-thyroid-gland-anatomy-and-functions",totalDownloads:5975,totalCrossrefCites:2,signatures:"Evren Bursuk",reviewType:"peer-reviewed",authors:[{id:"114874",title:"Dr.",name:"Evren",middleName:null,surname:"Bursuk",fullName:"Evren Bursuk",slug:"evren-bursuk"}]},{id:"31301",type:"chapter",title:"The Thyroglobulin: A Technically Challenging Assay for a Marker of Choice During the Follow-Up of Differentiated Thyroid Cancer",slug:"the-thyroglobulin-a-technically-challenging-assay-for-a-marker-of-choice-during-the-follow-up-of-dif",totalDownloads:2092,totalCrossrefCites:0,signatures:"Anne Charrié",reviewType:"peer-reviewed",authors:[{id:"64000",title:"Dr.",name:"Anne",middleName:null,surname:"Charrie",fullName:"Anne Charrie",slug:"anne-charrie"}]},{id:"31302",type:"chapter",title:"Papillary Thyroid Microcarcinoma - Do Classical Staging Systems Need to Be Changed?",slug:"papillary-thyroid-microcarcinoma-do-classical-staging-systems-need-to-be-changed-",totalDownloads:2209,totalCrossrefCites:0,signatures:"Carles Zafon",reviewType:"peer-reviewed",authors:[{id:"63070",title:"Dr.",name:"Carles",middleName:null,surname:"Zafon",fullName:"Carles Zafon",slug:"carles-zafon"}]},{id:"31303",type:"chapter",title:"Thyroid Neoplasm",slug:"thyroid-neoplasm",totalDownloads:2540,totalCrossrefCites:0,signatures:"Augusto Taccaliti, Gioia Palmonella, Francesca Silvetti and Marco Boscaro",reviewType:"peer-reviewed",authors:[{id:"114191",title:"Prof.",name:"Marco",middleName:null,surname:"Boscaro",fullName:"Marco Boscaro",slug:"marco-boscaro"},{id:"116633",title:"Dr.",name:"Augusto",middleName:null,surname:"Taccaliti",fullName:"Augusto Taccaliti",slug:"augusto-taccaliti"},{id:"136317",title:"Dr.",name:"Gioia",middleName:null,surname:"Palmonella",fullName:"Gioia Palmonella",slug:"gioia-palmonella"},{id:"137383",title:"Dr.",name:"Francesca",middleName:null,surname:"Silvetti",fullName:"Francesca Silvetti",slug:"francesca-silvetti"}]},{id:"31304",type:"chapter",title:"Thyroid Growth Factors",slug:"thyroid-growth-factors-",totalDownloads:2153,totalCrossrefCites:2,signatures:"Aleksander Konturek",reviewType:"peer-reviewed",authors:[{id:"112395",title:"Dr.",name:"Aleksander",middleName:null,surname:"Konturek",fullName:"Aleksander Konturek",slug:"aleksander-konturek"},{id:"139138",title:"Dr.",name:"Marcin",middleName:null,surname:"Barczynski",fullName:"Marcin Barczynski",slug:"marcin-barczynski"}]},{id:"31305",type:"chapter",title:"Vascular Endothelial Growth Factor (VEGF) and Epidermal Growth Factor (EGF) in Papillary Thyroid Cancer",slug:"angiogenesis-in-well-diferentiated-thyroid-cancer-",totalDownloads:1992,totalCrossrefCites:0,signatures:"Aleksander Konturek and Marcin Barczynski",reviewType:"peer-reviewed",authors:[{id:"112395",title:"Dr.",name:"Aleksander",middleName:null,surname:"Konturek",fullName:"Aleksander Konturek",slug:"aleksander-konturek"},{id:"139138",title:"Dr.",name:"Marcin",middleName:null,surname:"Barczynski",fullName:"Marcin Barczynski",slug:"marcin-barczynski"}]},{id:"31306",type:"chapter",title:"Immune Profile and Signal Transduction of T-Cell Receptor in Autoimmune Thyroid Diseases",slug:"cellular-immune-profile-and-tyrosine-phosphorylation-of-the-t-cell-receptor-and-allelic-variants-of-",totalDownloads:2277,totalCrossrefCites:0,signatures:"Adriano Namo Cury",reviewType:"peer-reviewed",authors:[{id:"104570",title:"Prof.",name:"Adriano",middleName:"Namo",surname:"Cury",fullName:"Adriano Cury",slug:"adriano-cury"}]},{id:"31307",type:"chapter",title:"Estrogen Signaling and Thyrocyte Proliferation",slug:"estrogen-signaling-and-thyrocyte-proliferation",totalDownloads:2182,totalCrossrefCites:1,signatures:"Valeria Gabriela Antico Arciuch and Antonio Di Cristofano",reviewType:"peer-reviewed",authors:[{id:"106329",title:"Dr",name:"Antonio",middleName:null,surname:"Di Cristofano",fullName:"Antonio Di Cristofano",slug:"antonio-di-cristofano"},{id:"112371",title:"Dr.",name:"Valeria Gabriela",middleName:null,surname:"Antico Arciuch",fullName:"Valeria Gabriela Antico Arciuch",slug:"valeria-gabriela-antico-arciuch"}]},{id:"31308",type:"chapter",title:"Suspicious Thyroid Fine Needle Aspiration Aspiration Biopsy: TSH as a Malignancy Marker?",slug:"suspicious-thyroid-fine-needle-aspiration-biopsy-tsh-as-a-maligancy-marker-",totalDownloads:2573,totalCrossrefCites:0,signatures:"Renata Boldrin de Araujo, Célia Regina Nogueira, Jose Vicente Tagliarini, Emanuel Celice Castilho, Mariângela de Alencar Marques, Yoshio Kiy, Lidia R. Carvalho and Gláucia M. F. S. Mazeto",reviewType:"peer-reviewed",authors:[{id:"108353",title:"Prof.",name:"Gláucia",middleName:null,surname:"Mazeto",fullName:"Gláucia Mazeto",slug:"glaucia-mazeto"},{id:"113354",title:"Ms.",name:"Renata",middleName:null,surname:"Araujo",fullName:"Renata Araujo",slug:"renata-araujo"},{id:"113355",title:"Prof.",name:"Célia",middleName:null,surname:"Nogueira",fullName:"Célia Nogueira",slug:"celia-nogueira"},{id:"113356",title:"Prof.",name:"Jose Vicente",middleName:null,surname:"Tagliarini",fullName:"Jose Vicente Tagliarini",slug:"jose-vicente-tagliarini"},{id:"113357",title:"Dr.",name:"Emanuel",middleName:null,surname:"Castilho",fullName:"Emanuel Castilho",slug:"emanuel-castilho"},{id:"113358",title:"Prof.",name:"Mariângela",middleName:null,surname:"Marques",fullName:"Mariângela Marques",slug:"mariangela-marques"},{id:"113361",title:"Prof.",name:"Yoshio",middleName:null,surname:"Kiy",fullName:"Yoshio Kiy",slug:"yoshio-kiy"},{id:"113362",title:"Prof.",name:"Lidia",middleName:null,surname:"Carvalho",fullName:"Lidia Carvalho",slug:"lidia-carvalho"}]},{id:"31309",type:"chapter",title:"Minimally-Invasive Parathyroid Surgery",slug:"minimally-invasive-parathyroid-surgery",totalDownloads:2137,totalCrossrefCites:0,signatures:"David Rosen, Joseph Sciarrino and Edmund A. Pribitkin",reviewType:"peer-reviewed",authors:[{id:"77863",title:"Dr.",name:"David",middleName:null,surname:"Rosen",fullName:"David Rosen",slug:"david-rosen"},{id:"145771",title:"Dr.",name:"Edmund",middleName:null,surname:"Pribitkin",fullName:"Edmund Pribitkin",slug:"edmund-pribitkin"},{id:"145772",title:"Dr.",name:"Joseph",middleName:null,surname:"Sciarino",fullName:"Joseph Sciarino",slug:"joseph-sciarino"}]},{id:"31310",type:"chapter",title:"Management of Primary Hyperparathyroidism: 'Past, Present and Future'",slug:"-management-of-primary-hyperparathyroidism-past-present-and-future-",totalDownloads:2745,totalCrossrefCites:1,signatures:"Sanoop K. Zachariah",reviewType:"peer-reviewed",authors:[{id:"78460",title:"Prof.",name:"Sanoop",middleName:"Koshy",surname:"Zachariah",fullName:"Sanoop Zachariah",slug:"sanoop-zachariah"}]},{id:"31311",type:"chapter",title:"Treatment Modalities in Thyroid Dysfunction",slug:"treatment-modalities-in-thyroid-dysfunction",totalDownloads:3530,totalCrossrefCites:0,signatures:"R. King and R.A. Ajjan",reviewType:"peer-reviewed",authors:[{id:"117824",title:"Dr.",name:"Ramzi",middleName:null,surname:"Ajjan",fullName:"Ramzi Ajjan",slug:"ramzi-ajjan"},{id:"117829",title:"Dr.",name:"Rhodri",middleName:null,surname:"King",fullName:"Rhodri King",slug:"rhodri-king"}]},{id:"31312",type:"chapter",title:"New Technologies in Thyroid Surgery",slug:"new-tecnologies-n-thyroid-sugery",totalDownloads:3553,totalCrossrefCites:1,signatures:"Bahri Çakabay and Ali Çaparlar",reviewType:"peer-reviewed",authors:[{id:"112958",title:"Dr.",name:"Bahri",middleName:null,surname:"Çakabay",fullName:"Bahri Çakabay",slug:"bahri-cakabay"},{id:"127809",title:"Dr.",name:"Ali",middleName:null,surname:"Çaparlar",fullName:"Ali Çaparlar",slug:"ali-caparlar"}]},{id:"31313",type:"chapter",title:"Management of Primary Hyperparathyroidism",slug:"surgical-management-of-primary-hyperparathyroidism",totalDownloads:4163,totalCrossrefCites:0,signatures:"Jessica Rose and Marlon A. Guerrero",reviewType:"peer-reviewed",authors:[{id:"84469",title:"Prof.",name:"Marlon",middleName:null,surname:"Guerrero Md",fullName:"Marlon Guerrero Md",slug:"marlon-guerrero-md"}]},{id:"31314",type:"chapter",title:"Synthetic and Plant Derived Thyroid Hormone Analogs",slug:"synthetic-and-plant-derived-thyroid-hormone-analogs",totalDownloads:13754,totalCrossrefCites:4,signatures:"Suzana T. Cunha Lima, Travis L. Merrigan and Edson D. Rodrigues",reviewType:"peer-reviewed",authors:[{id:"103114",title:"Dr.",name:"Suzana",middleName:"Telles",surname:"Cunha Lima",fullName:"Suzana Cunha Lima",slug:"suzana-cunha-lima"},{id:"109953",title:"BSc.",name:"Travis L.",middleName:null,surname:"Merrigan",fullName:"Travis L. Merrigan",slug:"travis-l.-merrigan"},{id:"136565",title:"Dr.",name:"Edson D.",middleName:null,surname:"Rodrigues",fullName:"Edson D. Rodrigues",slug:"edson-d.-rodrigues"}]},{id:"31315",type:"chapter",title:"Thyroid and Parathyroid Diseases and Psychiatric Disturbance",slug:"thyroid-disease-and-psychiatric-disturbance",totalDownloads:6131,totalCrossrefCites:1,signatures:"A. Lobo-Escolar, A. Campayo, C.H. Gómez-Biel and A. Lobo",reviewType:"peer-reviewed",authors:[{id:"116212",title:"Prof.",name:"Antonio",middleName:null,surname:"Lobo",fullName:"Antonio Lobo",slug:"antonio-lobo"}]},{id:"31316",type:"chapter",title:"Depressive Disorders and Thyroid Function",slug:"depressive-disorders-and-thyroid-function",totalDownloads:3029,totalCrossrefCites:0,signatures:"A. Verónica Araya, Teresa Massardo, Jenny Fiedler, Luis Risco, Juan C. Quintana and Claudio Liberman",reviewType:"peer-reviewed",authors:[{id:"40769",title:"Dr.",name:"Teresa",middleName:null,surname:"Massardo",fullName:"Teresa Massardo",slug:"teresa-massardo"},{id:"56394",title:"Dr.",name:"Verónica",middleName:null,surname:"Araya",fullName:"Verónica Araya",slug:"veronica-araya"},{id:"112810",title:"Dr.",name:"Jenny",middleName:null,surname:"Fieddler",fullName:"Jenny Fieddler",slug:"jenny-fieddler"},{id:"112811",title:"Dr.",name:"Luis",middleName:null,surname:"Risco",fullName:"Luis Risco",slug:"luis-risco"},{id:"112812",title:"Dr.",name:"Claudio",middleName:null,surname:"Liberman",fullName:"Claudio Liberman",slug:"claudio-liberman"},{id:"137069",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Quintana",fullName:"Juan Carlos Quintana",slug:"juan-carlos-quintana"}]},{id:"31317",type:"chapter",title:"Psychosocial Factors in Patients with Thyroid Disease",slug:"psychosocial-factors-in-patients-with-thyroid-disease",totalDownloads:3377,totalCrossrefCites:0,signatures:"Petra Mandincová",reviewType:"peer-reviewed",authors:[{id:"108499",title:"Dr.",name:"Petra",middleName:null,surname:"Mandincová",fullName:"Petra Mandincová",slug:"petra-mandincova"}]}]},relatedBooks:[{type:"book",id:"2552",title:"Lipid Metabolism",subtitle:null,isOpenForSubmission:!1,hash:"66b8e95379ce94691627be9279b5a616",slug:"lipid-metabolism",bookSignature:"Rodrigo Valenzuela Baez",coverURL:"https://cdn.intechopen.com/books/images_new/2552.jpg",editedByType:"Edited by",editors:[{id:"72355",title:"Prof.",name:"Rodrigo",surname:"Valenzuela Baez",slug:"rodrigo-valenzuela-baez",fullName:"Rodrigo Valenzuela Baez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"42113",title:"Overview About Lipid Structure",slug:"overview-about-lipid-structure",signatures:"Rodrigo Valenzuela B. and Alfonso Valenzuela B.",authors:[{id:"72355",title:"Prof.",name:"Rodrigo",middleName:null,surname:"Valenzuela Baez",fullName:"Rodrigo Valenzuela Baez",slug:"rodrigo-valenzuela-baez"},{id:"77415",title:"Dr.",name:"Alfonso",middleName:null,surname:"Valenzuela",fullName:"Alfonso Valenzuela",slug:"alfonso-valenzuela"}]},{id:"42114",title:"Oxidative Stress and Lipid Peroxidation – A Lipid Metabolism Dysfunction",slug:"oxidative-stress-and-lipid-peroxidation-a-lipid-metabolism-dysfunction",signatures:"Claudia Borza, Danina Muntean, Cristina Dehelean, Germaine Săvoiu, Corina Şerban, Georgeta Simu, Mihaiela Andoni, Marius Butur and Simona Drăgan",authors:[{id:"66403",title:"Mrs.",name:"Maria Corina",middleName:null,surname:"Serban",fullName:"Maria Corina Serban",slug:"maria-corina-serban"}]},{id:"42117",title:"The Role of Copper as a Modifier of Lipid Metabolism",slug:"the-role-of-copper-as-a-modifier-of-lipid-metabolism",signatures:"Jason L. Burkhead and Svetlana Lutsenko",authors:[{id:"139755",title:"Dr",name:null,middleName:null,surname:"Lutsenko",fullName:"Lutsenko",slug:"lutsenko"}]},{id:"42109",title:"The Role of Liver X Receptor in Hepatic de novo Lipogenesis and Cross-Talk with Insulin and Glucose Signaling",slug:"the-role-of-liver-x-receptor-in-hepatic-de-novo-lipogenesis-and-cross-talk-with-insulin-and-glucose-",signatures:"Line M. Grønning-Wang, Christian Bindesbøll and Hilde I. Nebb",authors:[{id:"139327",title:"Prof.",name:"Hilde",middleName:null,surname:"Nebb",fullName:"Hilde Nebb",slug:"hilde-nebb"},{id:"142337",title:"Dr.",name:"Line Mariann",middleName:null,surname:"Grønning-Wang",fullName:"Line Mariann Grønning-Wang",slug:"line-mariann-gronning-wang"}]},{id:"42110",title:"The 18 kDa Translocator Protein and Atherosclerosis in Mice Lacking Apolipoprotein E",slug:"the-18-kda-translocator-protein-and-atherosclerosis-in-mice-lacking-apolipoprotein-e",signatures:"Jasmina Dimitrova-Shumkovska, Leo Veenman, Inbar Roim and Moshe Gavish",authors:[{id:"64536",title:"Prof.",name:"Jasmina",middleName:"Dragan",surname:"Dimitrova-Shumkovska",fullName:"Jasmina Dimitrova-Shumkovska",slug:"jasmina-dimitrova-shumkovska"},{id:"114925",title:"Dr.",name:"Jehuda Arieh (Leo)",middleName:null,surname:"Veenman",fullName:"Jehuda Arieh (Leo) Veenman",slug:"jehuda-arieh-(leo)-veenman"},{id:"145484",title:"Prof.",name:"Moshe",middleName:null,surname:"Gavish",fullName:"Moshe Gavish",slug:"moshe-gavish"},{id:"145485",title:"MSc.",name:"Inbar",middleName:null,surname:"Roim",fullName:"Inbar Roim",slug:"inbar-roim"}]},{id:"42121",title:"Metabolism of Plasma Membrane Lipids in Mycobacteria and Corynebacteria",slug:"metabolism-of-plasma-membrane-lipids-in-mycobacteria-and-corynebacteria",signatures:"Paul K. Crellin, Chu-Yuan Luo and Yasu S. Morita",authors:[{id:"143195",title:"Dr.",name:"Yasu",middleName:"S.",surname:"Morita",fullName:"Yasu Morita",slug:"yasu-morita"},{id:"144799",title:"Dr.",name:"Paul",middleName:null,surname:"Crellin",fullName:"Paul Crellin",slug:"paul-crellin"},{id:"166027",title:"Mr.",name:"Chu-Yuan",middleName:null,surname:"Luo",fullName:"Chu-Yuan Luo",slug:"chu-yuan-luo"}]},{id:"42111",title:"Autophagy Regulates Lipid Droplet Formation and Adipogenesis",slug:"autophagy-regulates-lipid-droplet-formation-and-adipogenesis",signatures:"Yasuo Uchiyama and Eiki Kominami",authors:[{id:"139668",title:"Prof.",name:"Eiki",middleName:null,surname:"Kominami",fullName:"Eiki Kominami",slug:"eiki-kominami"}]},{id:"42107",title:"Metabolism of Short Chain Fatty Acids in the Colon and Faeces of Mice After a Supplementation of Diets with Agave Fructans",slug:"metabolism-of-short-chain-fatty-acids-in-the-colon-and-faeces-of-mice-after-a-supplementation-of-die",signatures:"Alicia Huazano-García and Mercedes G. López",authors:[{id:"139543",title:"Prof.",name:"Mercedes",middleName:"G.",surname:"López",fullName:"Mercedes López",slug:"mercedes-lopez"},{id:"142535",title:"MSc.",name:"Alicia",middleName:null,surname:"Huazano-Garcia",fullName:"Alicia Huazano-Garcia",slug:"alicia-huazano-garcia"}]},{id:"42118",title:"Lipid Metabolism, Metabolic Syndrome, and Cancer",slug:"lipid-metabolism-metabolic-syndrome-and-cancer",signatures:"Fang Hu, Yingtong Zhang and Yuanda Song",authors:[{id:"138861",title:"Dr.",name:"Yuanda",middleName:null,surname:"Song",fullName:"Yuanda Song",slug:"yuanda-song"}]},{id:"42106",title:"Impacts of Nutrition and Environmental Stressors on Lipid Metabolism",slug:"impacts-of-nutrition-and-environmental-stressors-on-lipid-metabolism",signatures:"Heather M. White, Brian T. Richert and Mickey A. Latour",authors:[{id:"139772",title:"Dr",name:null,middleName:null,surname:"Latour",fullName:"Latour",slug:"latour"},{id:"155014",title:"Dr.",name:"Heather",middleName:null,surname:"White",fullName:"Heather White",slug:"heather-white"},{id:"163087",title:"Dr.",name:"Brian",middleName:null,surname:"Richert",fullName:"Brian Richert",slug:"brian-richert"}]},{id:"42115",title:"Polydextrose in Lipid Metabolism",slug:"polydextrose-in-lipid-metabolism",signatures:"Heli Putaala",authors:[{id:"139084",title:"Dr.",name:"Heli",middleName:null,surname:"Putaala",fullName:"Heli Putaala",slug:"heli-putaala"}]},{id:"42112",title:"Spent Brewer’s Yeast and Beta-Glucans Isolated from Them as Diet Components Modifying Blood Lipid Metabolism Disturbed by an Atherogenic Diet",slug:"spent-brewer-s-yeast-and-beta-glucans-isolated-from-them-as-diet-components-modifying-blood-lipid-me",signatures:"Bozena Waszkiewicz-Robak",authors:[{id:"140925",title:"Prof.",name:"Bozena",middleName:null,surname:"Waszkiewicz-Robak",fullName:"Bozena Waszkiewicz-Robak",slug:"bozena-waszkiewicz-robak"}]},{id:"42120",title:"Lipid Involvement in Viral Infections: Present and Future Perspectives for the Design of Antiviral Strategies",slug:"lipid-involvement-in-viral-infections-present-and-future-perspectives-for-the-design-of-antiviral-st",signatures:"Miguel A. Martín-Acebes, Ángela Vázquez-Calvo, Flavia Caridi, Juan-Carlos Saiz and Francisco Sobrino",authors:[{id:"141163",title:"Dr.",name:"Francisco",middleName:null,surname:"Sobrino",fullName:"Francisco Sobrino",slug:"francisco-sobrino"}]},{id:"42116",title:"The Role of Altered Lipid Metabolism in Septic Myocardial Dysfunction",slug:"the-role-of-altered-lipid-metabolism-in-septic-myocardial-dysfunction",signatures:"Luca Siracusano and Viviana Girasole",authors:[{id:"139192",title:"Prof.",name:"Luca",middleName:null,surname:"Siracusano",fullName:"Luca Siracusano",slug:"luca-siracusano"},{id:"139193",title:"Dr.",name:"Viviana",middleName:null,surname:"Girasole",fullName:"Viviana Girasole",slug:"viviana-girasole"}]},{id:"42108",title:"Lipids as Markers of Induced Resistance in Wheat: A Biochemical and Molecular Approach",slug:"lipids-as-markers-of-induced-resistance-in-wheat-a-biochemical-and-molecular-approach",signatures:"Christine Tayeh, Béatrice Randoux, Frédéric Laruelle, Natacha Bourdon, Delphine Renard-Merlier and Philippe Reignault",authors:[{id:"140626",title:"Prof.",name:"Philippe",middleName:null,surname:"Reignault",fullName:"Philippe Reignault",slug:"philippe-reignault"}]},{id:"42122",title:"Jasmonate Biosynthesis, Perception and Function in Plant Development and Stress Responses",slug:"jasmonate-biosynthesis-perception-and-function-in-plant-development-and-stress-responses",signatures:"Yuanxin Yan, Eli Borrego and Michael V. Kolomiets",authors:[{id:"141200",title:"Prof.",name:"Michael",middleName:null,surname:"Kolomiets",fullName:"Michael Kolomiets",slug:"michael-kolomiets"},{id:"141211",title:"Dr.",name:"Yuanxin",middleName:null,surname:"Yan",fullName:"Yuanxin Yan",slug:"yuanxin-yan"}]},{id:"42119",title:"The Effect of Probiotics on Lipid Metabolism",slug:"the-effect-of-probiotics-on-lipid-metabolism",signatures:"Yong Zhang and Heping Zhang",authors:[{id:"141580",title:"Mr.",name:"Yong",middleName:null,surname:"Zhang",fullName:"Yong Zhang",slug:"yong-zhang"}]}]}],publishedBooks:[{type:"book",id:"705",title:"Hyperparathyroidism",subtitle:null,isOpenForSubmission:!1,hash:"52706600598f02abb3237828fb6cbfc4",slug:"hyperparathyroidism",bookSignature:"Gonzalo Diaz Soto and Manuel Puig-Domingo",coverURL:"https://cdn.intechopen.com/books/images_new/705.jpg",editedByType:"Edited by",editors:[{id:"92633",title:"Dr.",name:"Gonzalo",surname:"Díaz-Soto",slug:"gonzalo-diaz-soto",fullName:"Gonzalo Díaz-Soto"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1258",title:"Thyroid and Parathyroid Diseases",subtitle:"New Insights into Some Old and Some New Issues",isOpenForSubmission:!1,hash:"1d264ee64e50893c0a9e40405a70656e",slug:"thyroid-and-parathyroid-diseases-new-insights-into-some-old-and-some-new-issues",bookSignature:"Laura Sterian Ward",coverURL:"https://cdn.intechopen.com/books/images_new/1258.jpg",editedByType:"Edited by",editors:[{id:"40956",title:"Dr.",name:"Laura",surname:"Ward",slug:"laura-ward",fullName:"Laura Ward"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2538",title:"Glucocorticoids",subtitle:"New Recognition of Our Familiar Friend",isOpenForSubmission:!1,hash:"317d6ea020414596baedc9e33fc75c1d",slug:"glucocorticoids-new-recognition-of-our-familiar-friend",bookSignature:"Xiaoxiao Qian",coverURL:"https://cdn.intechopen.com/books/images_new/2538.jpg",editedByType:"Edited by",editors:[{id:"143871",title:"Dr.",name:"Xiaoxiao",surname:"Qian",slug:"xiaoxiao-qian",fullName:"Xiaoxiao Qian"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2552",title:"Lipid Metabolism",subtitle:null,isOpenForSubmission:!1,hash:"66b8e95379ce94691627be9279b5a616",slug:"lipid-metabolism",bookSignature:"Rodrigo Valenzuela Baez",coverURL:"https://cdn.intechopen.com/books/images_new/2552.jpg",editedByType:"Edited by",editors:[{id:"72355",title:"Prof.",name:"Rodrigo",surname:"Valenzuela Baez",slug:"rodrigo-valenzuela-baez",fullName:"Rodrigo Valenzuela Baez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2589",title:"Thyroid Hormone",subtitle:null,isOpenForSubmission:!1,hash:"10402e127b33c9f3f428b99add65a29c",slug:"thyroid-hormone",bookSignature:"Neeraj Kumar Agrawal",coverURL:"https://cdn.intechopen.com/books/images_new/2589.jpg",editedByType:"Edited by",editors:[{id:"136647",title:"Dr.",name:"N.K.",surname:"Agrawal",slug:"n.k.-agrawal",fullName:"N.K. Agrawal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"1258",title:"Thyroid and Parathyroid Diseases",subtitle:"New Insights into Some Old and Some New Issues",isOpenForSubmission:!1,hash:"1d264ee64e50893c0a9e40405a70656e",slug:"thyroid-and-parathyroid-diseases-new-insights-into-some-old-and-some-new-issues",bookSignature:"Laura Sterian Ward",coverURL:"https://cdn.intechopen.com/books/images_new/1258.jpg",editedByType:"Edited by",editors:[{id:"40956",title:"Dr.",name:"Laura",surname:"Ward",slug:"laura-ward",fullName:"Laura Ward"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"77027",title:"Microwave Assisted Synthesis of Organic Compounds and Nanomaterials",doi:"10.5772/intechopen.98224",slug:"microwave-assisted-synthesis-of-organic-compounds-and-nanomaterials",body:'
1. Introduction
Chemistry play major part in our daily life in the form of medicines, food colours, soaps, detergents, sunscreen lotions, toothpaste, pharmaceuticals, etc. what we use in our daily life literally everything. Scientist from various disciplines had used their knowledge and skill to produce these materials. To produce these chemicals in industries and laboratory several techniques are used like stirring, heating, refluxing, protection of specific functional group and deprotection of them. Several harmful materials were also generated during the above processes causing environment pollution. To combat these problems, Green Chemistry has emerged as a challenge for scientist from industries and academia to develop the synthetic process for sustainable development of society in last few decades. In this context, several green synthetic techniques were developed to generate a vast library of organic compounds.
In the Conventional laboratory or industry heating technique involve Bunsen burner, heating mental/hot plates/furnace/oil bath and electric heating ovens. These process comprise the heating of walls of vessels first by convection or conduction of energy then the reaction content, leading to much longer time to achieve the target temperature. These techniques not only give useful materials but also give so many by products in the form of solid, liquid and gases, resulting to lot of chemical pollution to mankind as well as for other living creatures on Earth. Furthermore, to produce these useful materials, several resources are also going to be consumed. To combat these problems the various arena of Scientist are trying to develop new Green techniques.
Conventional heating usually involves the use of a furnace or oil bath, which heats the walls of the reactor by convection or conduction method. The core of the sample takes much longer to achieve the target temperature, e.g. when heating a large sample of ceramic bricks (Figure 1). The microwave portion of electromagnetic radiation is emerged a significant area in the acceleration of chemical reactions in 1980s. A number of reviews were reported by various scientists [1, 2, 3, 4, 5, 6, 7, 8, 9, 10]. There are three main reasons for its special place of microwave (MW) assisted synthesis. The first point is high heating efficiency caused by MW energy, which reaches and absorbed directly by substance. The second is selectivity i.e. having dielectric polar molecule will absorb this energy. And thirdly enhancement of chemical syntheses by the MW effect or non-thermal effect. In other sense, the microwave irradiation energy acts as internal heat source, which is able to heat the target compounds without heating the entire furnace or oil bath, consequently, saves time and energy. It produces more uniform heating. This unconventional energy source (MW) has been used to heat food stuff since more than 5 decades and now the concept is also utilized to accelerate a wide range of chemical reactions. The organic synthesis has very special and significant role in the improvement of day to day life of human being from morning toothpaste to all useful medications/drugs, plastic/polymer materials etc. To produce these useful substance in reasonable time and environment friendly manner is the prime responsibility of the scientist of several discipline. In this regard Microwave heating technique has blossomed in a variety of applications in Organic Synthetic methods. Although the initial synthetic work was performed in domestic Microwave ovens but recently most organic reactions are carried out in dedicated high speed specialized Microwave equipment with appropriate pressure and temperature control.
Figure 1.
Process of heating.
Microwaves (MW) are the electromagnetic waves, having shortest wavelength of radio spectrum. The word microwave means “a very short wave”. Microwave irradiation is a low energy phenomena as compared to other radiations. The energy of MW is about 0.0016 eV at 2450 MHz, which is very low to break any chemical bond. However, a microwave energy can effect a number of chemical transformation. When a substance is exposed to microwave energy, then three process can occur. Firstly, if it is a conductor metal, then MW will be reflected and it cannot be heated. Secondly, if insulator material is exposed to MW it will be not heated since it is MW transparent. Thirdly if material is dielectric in nature then MW energy will be absorbed and gets heated. This case is very interesting for a Chemist.
A microwave works by directly coupling with polar molecule in a reacting species. Microwaves radiation are a form of non-ionizing electromagnetic radiation with 300 MHz to 300 GHz frequency with the corresponding wavelength 1 mm to 1 m, which places MW in between Infrared radiations and radio waves. The molecules get heated in microwave irradiation process by a dielectric heating phenomenon. The electric dipoles, i.e. a partial positive charge at one end and a partial negative charge at the other, rotate as they try to align themselves with the alternating electric field of the microwaves. Additionally, molecular rotation occurs in a material/food (containing polar molecules) causing electric dipole moment which can partially/completely aligned themselves with an applied electromagnetic field. Since electromagnetic field alternates, the rotating molecule resulting they change their directions by pushing/pulling/colliding. Rotating molecules hit other molecules and put them into motion, thus dispersion of energy happens. This energy, dispersed as molecular rotations, vibrations and/or translations in solids and liquids, raises the temperature of the food, in a process similar to heat transfer by contact with a hotter body. It is a common misconception that microwave ovens heat food by operating at a special resonance of water molecules in the food. As noted microwave ovens can operate at many frequencies.
Additionally, nanomaterials or nanoparticles (NPs) are the materials having a single unit small sized between 1 and 100 nm. During the past few decades nanoparticles research have become a subject of intensive interest because of its potential applications in various fields i.e. biosensing, drug delivery, bioimaging, catalysis, lubrication, electronics, textile manufacturing, water treatment systems. Nanoparticles (NPs) are synthesized from several types of materials i.e. inorganic, organic, hybrid and biological by adopting various methods. The main methods are ball milling, vapor deposition, electro-spraying, reduction of metal salts, sol–gel, coprecipitation and thermal decomposition for inorganic NPs. While organic NPs are synthesized by microemulsion, nanoprecipitation, dialysis and rapid expansion of supercritical solutions. Hybrid NPs are synthesized from both organic and inorganic materials. However, the present trend for the synthesis of nanomaterials endures a challenge to redesign the synthetic strategies offering the use of less hazardous chemicals and reduction in the reaction time and required energy. In this context, microwave (MW)-assisted methods can be considered as a promising green approach for synthesis of nanomaterials and nanocomposites. Besides, MW-assisted strategies offer a homogenous heating with reliable nucleation and growth environment leading to the formation of NPs with uniform size. Several reviews were reported on microwave assisted synthesis of NPs [11, 12].
2. Microwave equipment
Though the range of MW frequencies is 0.3 to 300 GHz, out of this most of the frequencies are used in Radar and Telecommunication equipment. However very limited frequency range can be used in microwave heating equipment i.e. 2.45 GHz corresponding to 12.2 cm wave length. So almost all domestic and commercial microwave heating equipment either for domestic or scientific purpose has a fixed frequency 2.45 GHz. In general MW accelerated reactions are carried out either domestic microwave oven or especially designed microwave equipment. These equipment works in between 500 to 1500 W power. In these ovens Microwaves are generated by magnetron, and the temperature is maintained by turning this on and off. The generated microwaves are travelled into vessel (cavity) and reflected back by the walls of cavity. If the generated microwaves are not absorbed, it may reflect back down and damage the magnetron. Thus it is essential to have microwave active dummy load should be used during the process, which will absorb excess microwave and prevent such damage.
3. Solvent used in MOAS
In Microwave solid and liquid phase reactions can be performed at various conditions. The boiling point of solvents will be raised by 250 C with their actual boiling points during the process of microwave heating [13]. Although all type of solvents can be used in MOAS, however DMF, ethanol and water are the best solvents for this process, since they absorb MW radiation and heat the content efficiently. All polar solvents comprising OH groups are suitable for MW reactions, since they can able to absorb MW energy. Water, alcohols (ethanol & isopropanol), amides, acetonitrile and acids (acetic and formic) are some of the commonly used solvents in this process. The polarity order of these solvents are like
Water>Acids>Amides>AlcoholsE1
The less polar or non-polar solvents are transparent to microwave irradiation i.e. could not absorb MW energy and consequently will not get heated in the pure form. However in general the reaction mixture content contains enough polar or ionic substance, which can absorb microwave irradiation and generate heat to complete the reactions. Moreover small amount of polar or ionic additives could be added to enhance the absorption capacity of reaction content having less dielectric properties of less polar solvents. The energy transfer between polar molecule and non polar solvents under microwave irradiation is so rapid and efficient leading to proceed a variety of chemical transformation and thus a very good alternative for conventional techniques in tune with green chemistry [14].
4. Types of microwave energy assisted synthesis
In general two types of Microwave assisted synthesis were reported in literature: -
Microwave assisted synthesis using solvents
Microwave assisted synthesis without solvents or solvent free conditions
The reports on Microwave assisted synthesis are well documented in the literature since last 5 decades, which includes mainly following reactions Figure 2.
Figure 2.
Various types of Microwave assisted synthesis.
There are several synthesis which can be performed in presence of solvent under microwave conditions:.
Hydrolysis:
The hydrolysis of benzyl chloride can be successfully done within 3 minutes in MW while normally it takes 35 min.
C6H5CH2Cl+H2O→MW,3minC6H5CH2OHE2
Similarly hydrolysis of benzamide in presence of sulphuric acid can be completed in 7 mins instead of one hr. under MW.
The acid-sensitive 3-hydroxyacetals and 3-methoxyacetals being hydrolyzed efficient method in minutes in good yields. In this paper reports on efficiently hydrolyzed acetals with silica gel-supported pyridinium tosylate moistened with water in solvent-free conditions under microwave irradiation were reported [15]. Since the hydrolysis of carboxylic acid esters is one of the most studied chemical reactions Safari et al. had reported Microwave-assisted expeditious hydrolysis of isobenzofuranone derivatives using silica supported acid under organic solvent-free conditions [16].
Oxidation:
The oxidation of Toluene with potassium paramagnet usually takes 10–12 hrs in normal condition, however under MW condition within 5 mins it is converted to benzoic acid [17].
E4
Since the oxidation of alcohols plays a significant role in organic synthesis and as carbonyl compounds are widely used as intermediates both in manufacturing and laboratory. The progress of new oxidative methods continues to be a focus of research area in spite of the availability of several protocols to achieve such objectives. Bogdał and Łukasiewicz reported [18] an interesting protocol of oxidation of primary and secondary alcohols into equivalent carboxylic acids and ketones within 10–20 min using 30% aqueous hydrogen peroxide and commercially available catalysts under microwave irradiation. The application of hydrogen peroxide as an oxidant is appreciated because water is the sole expected side product.
Further, alcohols are adsorbed on clayfen easily oxidized to carbonyl compounds under solvent-free conditions in microwaves. By this rapid, selective and environmentally benign method, the use of excess solvents and toxic oxidants usually employed can be avoided. Varma and Dahiya reported the oxidation of alcohols to the corresponding carbonyl compounds in presence of clay-supported iron(III) nitrate, under solvent-free dry microwaves conditions [19].
Esterification:
The esterification of benzoic acid can be achieved in 6 mins only [20] in the presence of catalytic amount of sulphuric acid under MW conditions.
Since esters are one of the important products for all industrial applications. In this context convenient and feasible technique for synthesis of esters was reported [21, 22] in dry media and using heteropoly acid as catalyst respectively under microwave irradiation in the absence of organic solvents.
Recently Reilly et al. [23] demonstrated the microwave assisted esterification reaction to undergraduate student, which is a good initiative to develpo the interest among students about green chemistry.
Decarboxylation:
The conventional decarboxylation of carboxylic acid usually carried out in presence of quinolone by refluxing the acid however in microwave it can be done in very less time [24].
E6
The reports on microwave assisted decarboxylation of malonic acid derivatives are available in the literature [25]. They carried out these reactions under solvent-free and catalyst free conditions. This new method produces the corresponding carboxylic acid in a pure manner and with a high yield within short time: 3–10 min.
Multicomponent reactions
The multi component reaction (MCR) approach has emerged as a promising alternative to incorporate the various diversity in a single step reaction to produce diverse library of important compounds. A rapid one-pot synthesis of imidazo [1,2-a] annulated pyridines, pyrazines and pyrimidines was described by Varma and Kumar, in the presence of recyclable montmorillonite K 10 clay under solvent-free conditions using microwave irradiation [26, 27]. They condensed three components viz.: aldehydes(aliphatic/ aromatic/vinylic); isocyanides (aliphatic/aromatic/cyclic) and amines (2-aminopyridines, 2-aminopyrazines and 2-aminopyrimidines in presence of catalytic amount of clay in solvent free microwave irradiation.
Mahmood et al. 2017 conveniently synthesized thiazolidinones from aldehydes, thiosemicarbazide and maleic anhydride in the presence of KSF@Ni as heterogeneous catalyst in one-pot three-component reaction under microwave irradiation in good yield in short reaction time [28].
The metal free the microwave assisted synthetic multicomponent approach for N-unsustituted-1,2,3-triazoles was recently reported by Garg et al. [29]. They used aromatic aldehydes, nitroalkane and sodium azide for synthesis, which demonstrates great scope to be utilized by future generation for production of novel biological active molecules.
Since acridines and acridinium ions are one of the important compounds, as they are used in pharmaceuticals, materials, dyes and photo-catalysis. Mandal et al., 2020, reported [30] an unconventional FeCl3-alcohol catalysed one-pot synthesis of these materials by aldehydes, 1,3-cyclohexanedione and amines under microwave conditions. They beautifully merged high atom-economy and multicomponent reaction with novel iron catalyzed dehydrogenation, using aerobic oxygen as the terminal oxidant, in alcoholic solvent to produce water as the by-product.
Condensation reaction
Several known transformation such as hydrolysis of ester or amide, Diels-Alder cycloaddition, Fisher Indole synthesis were investigated in a microwave reactor, in near critical water (NCW) under microwave assisted synthesis and reported [31].
Ashry and Kassem, 2006 has given a comprehensive account [32] of synthesis of Six, Seven membered, Spiro and Fused Heterocycles under microwave conditions.
Naqvi et al. 2009 were developed and synthesized some Schiff bases under microwave irradiation by taking 3-chloro-4-fluoro aniline and various substituted benzaldehydes [33]. They used other green chemistry approach also for their synthesis.
The thermal effect of microwaves were shown in 2006 by condensing ortho-diphenylamine in acetic acid and observed that by conventional means it took 9 weeks while in MW only tem minutes [34]. It was a great findings and opportunities for synthetic chemists.
E7
Conditions
Temperature/Pressure
Time
Conv
25°C
9 weeks
Conv
60°C
3 days
Conv
100°C
5 hrs
MW
130°C /2 bar
1 h
MW
160°C/ 4 bar
10 min
MW
200°C /9 bar
3 min
MW
270°C / 29 bar
1s
Sondhi et al., 2010; have developed microwave assisted synthesis of complex tri-an d tetracyclic heterocyclic molecules in a simple, high yielding, one step process [35]. They synthesized these important moieties by condensing of dicarboxylic acids with diamines under solvent-free condition.
The design and synthesis of novel structures having α, β-unsaturated ketone moieties, responsible for the bioactivities of the Mannich bases were carried out by Mete et al. [36]. The target compounds were synthesized by the conventional heating method and also by the microwave irradiation method. They optimized the conditions which can be explored by future researcher.
The reports on the condensation reaction between active methylene group and various aldehydes are well documentated in literature since several decades for their potential diverse biological activities especially for anticancer activities [37]. Furthermore, the various substituted aromatic aldehydes and Thiazolidine-2,4-dione were reacted under microwave irradiation using water as green solvent by simple Knoevenagel condensation. They tried various solvent conditions aqueous ethanol, H2O, DMF, DMSO, and solvent less under MW irradiation [38] and found the water as the best suitable solvent.
The 1,3,5-trisubstituted benzene was synthesized by self-condensation of enamines, enaminones and enaminoester in the presence of pyridinium chloride ([PyH]Cl) in short time in domestic MW oven and ionic liquids in year 2010 with appreaciable yield [39]. Brun et al. 2015 prepared boric acid catalyzed novel acetophenone derivatives with methylene compounds under solvent free microwave assisted condensation reactions [40]. They prepared a large number of compounds having sensitive acid and base function groups in substrates. Knoevenagel Condensation.
A comprehensive review on reactions of cyano malononitrile-derivatives under Microwave Radiation was also reported recently [41]. The Knoevenagel condensation between aromatic aldehydes or ketones and malonic acid in the presence of tetrabutyl ammonium bromide and K2CO3 was carried out and reported by Gupta and Wakhloo 2007 under microwave irradiation in water. The yields of products were excellent with high purity [42].
Cycloaddition reactions
Since Computational calculations emerged as a significant tool to study reaction kinetics and strategies in last couple of decades. de Cozar et al. [43] studied the thermal and non-thermal effects of microwave irradiation and determined the thermodynamic and kinetic parameters of the reaction. They performed the computational study of two previously reported cycloaddition reactions and analysed the presence of a thermal effect which is responsible for the microwave irradiation that produces changes in the regioselectivity or in the reaction mechanism.
The 1,2,3- triazoles are one of the most active moieties presents in several types of drug candidate. So, the convenient synthesis is a hot topic among various researchers. The catalyst and solvent free synthesis of substituted triazoles via cycloaddition of trimethylsilylazide and acetylenes were carried out recently by Roshandel et al. [44] under microwave conditions In the same year Expeditious microwave assisted synthesis and bio-evaluation of novel bis (trifluoromethyl) phenyl-triazole-pyridine hybrid analogues by click chemistry approach under microwave irradiation was reported from our group [45].
Coupling reactions
The efficient synthesis of 2,3 disubstituted-6-aminoquinoxaline derivatives were prepared efficiently by applying Microwave assisted Sonogashira Coupling by Lee et al. in 2013. They prepared a library of compounds by very region-selective MW conditions [46]. The mini-review on the Suzuki-Miyaura and on the Heck cross-couplings of nucleosides under microwave irradiations reported as an alternative technology in tune with green chemistry [47]. A simple microwave assisted synthesis of isoindolinones bearing a quaternary C-atom, introducing a Pd-mediated tandem-coupling reactions are reported recently [48]. As Cross-coupling reactions furnishing carbon–carbon (C–C) and carbon–heteroatom (C–X)bond is still one of the most challenging area in organic syntheses. Younis Baqi has reported [49] a comprehensive review on Recent Advances in Microwave-Assisted Copper-Catalyzed Cross-Coupling Reactions very recently. The microwave energy was also used in the synthesis of Ribonucleosides using natural phoshphate as catalyst in 2013 by Ouzebla et al. [50]. The hydrogenation of Levulinic acid to γ-Valerolactone in presence of Ru/TiO2 catalysts was reported very recently by Howe et al. 2019 [51]. The one-pot microwave-assisted polyol method was found to be highly efficient. The preparation temperature, microwave irradiation time and choice of Ru precursor have a significant effect on catalyst activity.
The extraction of bioactive components from fruits of Ficus racemosa was recently carried out by Sharma et al. 2020 under the microwave – assisted extraction (MAE). They developed the optimum condition for MAE at 3.5 pH,360.55 W microwave power in 30.01 s, which can be used as promising green technology to extract other useful materials from other natural sources [52]. The microwave synthesis of hybrid inorganic–organic porous materials was reported by Jhung et al. 2006. They observed phae selective rapid crystallization of hybrid material by MW method, which could be better alternative method to be explored further [53].
The comparative study of conventional and Microwave induced organic reaction enhancement (MORE) methodologies was carried out to synthesize some selected heterocyclic molecules and found more efficient over conventional classical methods in 2010 [54]. Kitchen et al. 2014 reported [55] a comprehensive review on the significant advances in the area of solid-state MW synthesis in context with future scope in the 21st century. They also presented the merits of MW heating along with understanding of MW heating and interaction mechanisms. The major focus of the review is on the use of MW heating to make novel improved materials with MW heating. They analytically discussed the developments in MW techniques and instrumentation and their potential to foster interest among the materials chemistry research and industrial communities and to explore the access to MW method.
However, Guadino et al. 2013, reported a comprehensive review on potential application of MW heating to accelerate heterogeneous reactions under gaseous reagent i.e. CO and CO2, which gave a new insight to various scientist to explore the MW heating method. Since the poisonous nature of CO and high cost of CO2 storage restricted various resercher to use as heterogeneous medium, so the concept of dielectric heating can be further explored viaMW heating protocol [56]. Recently Darekara et al. 2020, synthesized a series of derivatives of thiadiazoles and triazoles under microwave conditions. They also explored their antibacterial activities [57].
5. Synthesis of nano particles
As Nanoscience and nanotechnology are new frontiers of this century in all facet of human life and comfort. Nanoparticles are important components in a wide type of applications, including medicine, semiconductors, catalysis, and energy. Microwave energy has the potential to selectively heat either the solvent or the precursor molecules for nanomaterial preparation. In this process of heating rapid temperature rise allows nanomaterial synthesis to take place in a homogeneously mixed precursor solution To produce nano materials or particles by using microwave technology is a need of hour in context of green chemistry also. The silver nanoparticle has an importance place in biomedical and catalytical field. Its easy synthesis is a hot topic of research. The template MW Synthesis of silver nanoparticles were carried out [58] from silver nitrate and starch solution. They performed the synthesis under direct heating, controlled heating, and microwave irradiation. The Starch acted as a reductant as well as a capping material to protect the nanoparticles surfaces and prevents the particles from aggregation.
Additionally, the MW heating technique is also useful for the preparation of superior nanomaterials from direct heating of the various molecular precursors. The microwave-assisted process involve reduction of metal salts either in organic solvents or in aqueous medium in presence or absence of surface-directing agents in one-pot synthesis [59].
As Ionic liquids, due to their high ionic conductivity and polarizability, were an excellent microwave-absorbing agent, have also been used for the synthesis of metal nanostructures. By changing the various parameters i.e. precursor, precursor concentration, solvent, microwave power, pressure and temperature different metallic nanostructures in numerous sizes and morphologies have been prepared. Many simple and complex metal oxides have been also synthesized by using the microwave-assisted route. The microwave hydrothermal method has been used to prepare a large variety of binary and ternary oxides such as.
Motshekga et al. reported [70] a comprehensive review on the synthesis and applications of carbon-nanotube-coated metal/oxides nanoparticles under the microwave-assisted method. They explained various studies in which the microwave-assisted synthesis method of the composites formation will be completed in a shorter reaction time with uniform and well-dispersed nanoparticle.
A simple and microwave irradiation method for the biosynthesis of silver nanoparticles (SNPs) using aqueous leaf extract of Origanum majorana and Citrus sinensis as a novel bio source of cost-effective, non-hazardous reducing, and stabilizing agents was reported [71]. The microwave heating made the synthesis of SNPs fast, uniform, and reproducible. They also exhibited good antibacterial activity against E. coli and B. subtilis pathogens.
Similarly five plant extracts of Syzygium aromaticum, Origanum vulgare, Origanum majorana, Theobroma cacao and Cichorium intybus were used [72] for microwave assisted synthesis of alumina nanoparticles from Aluminum nitrate. On analysis of XRD pattern of particles synthesized with S. aromaticum showed semi-crystalline structure however others showed nano dimension of particles or amorphous structure nanoparticles.
The microwave-assisted sol–gel synthesis of high-quality and uniform ZnFe2O4 nanocrystals were performed by Suchomski et al. [73]. They described these novel nano particles. Additionally, the synthesis of magnetite and maghemite nanoparticles with well-controlled size, high crystallinity and good magnetic properties, in less reaction time was developed under microwave irradiation method [74]. It was observed that microwave power and heating time are the main parameters controlling the size of the nanoparticles and the presence of maghemite, while ammonia concentration does not strongly affect it.
The magnetic metallic nickel nanoparticles were synthesized by reacting simple nickel chloride as precursor, ethylene glycol as solvent and ethanol used as reducing agent following microwave-assisted method using a monomode microwave reactor by Zuliani et al. [75]. They achieved metallic nickel in five minutes at 250°C under MW conditions, which showed high catalytic activity for the hydrogenolysis of benzyl phenyl ether.
Further, fabrication of small anatase titanium dioxide (TiO2) nanoparticles (NPs) attached to larger anisotropic gold (Au) morphologies by a very fast and simple two-step microwave-assisted synthesis was performed by May-Masnou et al. [76]. They also evaluated the photocatalytic activity of the two Au/TiO2 NPs, in the photoproduction of hydrogen from gaseous water/ethanol mixtures at ambient temperature and pressure.
The amazing utilization of microwave energy and nanotechnology to improve the printability and performance of cotton prints via screen printing technique was reported [77]. They pre-treated each cotton sample separately by microwave power in the range of 300 to 700 watts for a period of 1 to 9 min. Then the optimum sample was printed by printing paste comprising a reactive dye Remazol™ and silver nanoparticles (Ag-NPs) with diverse concentrations. Further, the printed samples were fixed using MW energy lateron subjected to steaming or thermo-fixation. On the analysis of results indicated that, the prints obtained using microwave and Ag-NPs were found to have better colour strength, fastness properties, antibacterial behaviour and surface morphology as compared to the conventional techniques.
Though the conventional wet chemical synthetic method is still the most widely used method for nanoparticle synthesis due to its simplicity, inexpensive processing, and scalable nature. But nanoparticles produced by this route tend to agglomerate after some time, in particular at high temperature and pressure, resulting to a gradual loss of activity. To tackle these challenges a facile and scalable thermal shock synthesis method based on microwave irradiation for the rapid synthesis of nanoparticles on a reduced graphene oxide (RGO) substrate was demonstrated by Xu et al. 2019 very recently [78]. By loading precursors onto RGO, with medium amount of defects can efficiently absorb microwaves leading to rapid temperature change resulting uniform nanoparticles synthesis. This technique is also known as defect engineering. The beauty of this technique is scalable i.e. has potential in large-scale production nanoparticles.
6. Conclusion
In last couple of decades, the application of Microwave enegy has emerged a promising tool for synthesis of novel molecule in the area of drug research, in synthesis of nano material, in catalyst field, in inorganic synthesis, in CO and CO2 capture reactions, paint industry, in extraction of products from natural sources etc. It blossemed as a reliable alternavite of conventional heating due to high speed or shortening of reaction time; simplicity i.e.reaction can be performed in sealed and open glass vials with wide range of options; with high productivity i.e. almost 200–400% more than conventional means. The MW assisted reactions will be a one of the best method to synthesise diverse type of molecules of interest.
Conflict of interest
None.
\n',keywords:"Green synthesis, Microwave synthesis, Organic reactions, Nanomaterials",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/77027.pdf",chapterXML:"https://mts.intechopen.com/source/xml/77027.xml",downloadPdfUrl:"/chapter/pdf-download/77027",previewPdfUrl:"/chapter/pdf-preview/77027",totalDownloads:399,totalViews:0,totalCrossrefCites:0,dateSubmitted:"July 17th 2020",dateReviewed:"May 3rd 2021",datePrePublished:"June 4th 2021",datePublished:"September 15th 2021",dateFinished:"June 3rd 2021",readingETA:"0",abstract:"In the Conventional laboratory or industry heating technique involve Bunsen burner, heating mental/hot plates and electric heating ovens. To produce a variety of useful compounds for betterment of mankind, the Microwave Chemistry was introduced in year 1955 and finds a place in one of the Green chemistry method. In Microwave chemistry is the science of applying microwave radiation to chemical reactions. Microwaves act as high frequency electric fields and will generally heat any material containing mobile electric charges, such as polar molecules in a solvent or conducting ions in a solid. Polar solvents are heated as their component molecules are forced to rotate with the field and lose energy in collisions i.e. the dipole moments of molecules are important in order to proceed with the chemical reactions in this method. It can be termed as microwave-assisted organic synthesis (MAOS), Microwave-Enhanced Chemistry (MEC) or Microwave-organic Reaction Enhancement synthesis (MORE). Microwave-Assisted Syntheses is a promising area of modern Green Chemistry could be adopted to save the earth.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/77027",risUrl:"/chapter/ris/77027",signatures:"Anjali Jha",book:{id:"10469",type:"book",title:"Nanofibers",subtitle:"Synthesis, Properties and Applications",fullTitle:"Nanofibers - Synthesis, Properties and Applications",slug:"nanofibers-synthesis-properties-and-applications",publishedDate:"September 15th 2021",bookSignature:"Brajesh Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/10469.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-426-5",printIsbn:"978-1-83968-425-8",pdfIsbn:"978-1-83968-427-2",isAvailableForWebshopOrdering:!0,editors:[{id:"176093",title:"Dr.",name:"Brajesh",middleName:null,surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"327522",title:"Prof.",name:"Anjali",middleName:null,surname:"Jha",fullName:"Anjali Jha",slug:"anjali-jha",email:"ajhamani@gitam.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Microwave equipment",level:"1"},{id:"sec_3",title:"3. Solvent used in MOAS",level:"1"},{id:"sec_4",title:"4. Types of microwave energy assisted synthesis",level:"1"},{id:"sec_5",title:"5. Synthesis of nano particles",level:"1"},{id:"sec_6",title:"6. Conclusion",level:"1"},{id:"sec_10",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Lidstrom P, Tierney J, Wathey B, Westman J. Microwave assisted organic synthesis-a review . Tetrahedron 2001, 57 9225-9283'},{id:"B2",body:'Kappe O C. Controlled Microwave heating in Modern Organic Synthesis. Angew. Chem.Int.Ed. 2004, 43, 6250-6284; DOI:10.1002/anie.200400655'},{id:"B3",body:'Wolkenberg SE, Shipe WD, Lindsley CW, Guare JP, Pawluczyk JM. Applications of microwave-assisted organic synthesis on the multigram scale. Current Opinion in Drug Discovery and Development, 2005, 8(6): 701-708'},{id:"B4",body:'Kappe O C, Dallinger D, The impact of microwave synthesis on drug discovery, Nature Reviews Drug Discovery, 2006, 5, 51-63'},{id:"B5",body:'Man A K, Shahidan R. Microwave-assisted Chemical Reactions. J Macromolecular Science Part A, 2007, 44(6) 651-657. doi:10.1080/10601320701285136'},{id:"B6",body:'Rajak H, Jain D P, Dewangan P K, Patel V, Agrawal N. application of Microwaves in Organic Synthesi: speeding up the Process of drug Discovery. RGUHS JmPharm Sci. 2013, 3(1) 16-23'},{id:"B7",body:'Lukasik N, Wysiecka EW. A Review of Amide Bond Formation in Microwave Organic Synthesis. Current Organic Synthesis. 2014, 11(4)'},{id:"B8",body:'Frecentese F, Saccone I, Caliendo G, Corvino A, Fiorino F, Magli E, Perissutti E, Severino B, Santagada V. Microwave Assisted Organic Synthesis of Heterocycles in Aqueous Media: Recent Advances in Medicinal Chemistry. Medicinal Chemistry, 2016, 12(7)'},{id:"B9",body:'Naina S, Singha R, Ravichandran S. Importance of Microwave Heating in Organic Synthesis. Advanced Journal of Chemistry-Section A, 2019, 2(2) 94-104'},{id:"B10",body:'Kumara A, Kuang Y, Liang Z, Sun X, Microwave chemistry, recent advancements, and eco-friendly microwave-assisted synthesis of nanoarchitectures and their applications: a review. Materials Today Nano, 2020, 11, 100076'},{id:"B11",body:'Anuj Kumarabd Yun Kuangab ZhengLiangc Xiaoming Sun; Materials Today Nano, Volume 11, August 2020, 100076'},{id:"B12",body:'M. Gnana Ruba Priya, Bincy Raj and Rashmi T. A REVIEW ON MICROWAVE ASSISTED SYNTHESIS OF SOME NANOPARTICLES, European Journal of Biomedical and Pharmaceutical Sciences,2020,7(7), 691-700'},{id:"B13",body:'Baghurst D R, Mingos DMP. Superheating effect associated with microwave dielectric heating. J Chem Soc, Chem, Commun. 1992, 674-677'},{id:"B14",body:'Colombo M, Peretto I Chemistry stratergies in early drug discovery: an overview of recent trends. Drug Discov. Today, 2008, 13, 677-684'},{id:"B15",body:'He Y, Johansson M, Sterner O. Mild Microwave-Assisted Hydrolysis of Acetals Under Solvent-Free Conditions. Synthetic Communication, 2004, 4: 22, 4153-4158, DOI:10.1081/SCC-200036616'},{id:"B16",body:'Safari J, Banitaba S H, Khalili S D. Microwave-assisted expeditious hydrolysis of isobenzofuranone derivatives using silica supported acid under organic solvent-free conditions Arabian Journal of Chemistry, 2011, 4(1),11-15'},{id:"B17",body:'Gedye R N, Smith F E, Westaway K C, The rapid synthesis of organic compounds in microwave ovens, Canadian Journal of Chemistry, 1988, 66(1),17'},{id:"B18",body:'Bogdał D, Łukasiewicz M, Microwave-assisted oxidation of alcohols using aqueous hydrogen peroxide. Synlett 2000, 1(1): 143-145'},{id:"B19",body:'Varma R S, Dahiya R, Microwave assisted oxidation of alcohols Under solvent free conditions using clayfen, Tetrahedron Letters; 1997, 38 (12) 2043-2044. doi:10.1016/S0040-4039(97)00262-1'},{id:"B20",body:'Gedye, R., Smith, F., Westaway, K., Ali, H., Baldisera, L., Laberge, L. and Rousell, J. ; The Use of Microwave Ovens for Rapid Organic Synthesis. Tetrahedron Letters, 1986, 27, 279-282. doi:10.1016/S0040-4039(00)83996-9'},{id:"B21",body:'Loupy A, Petit A, Ramdani Md, Yvanaeff C, Majdoub M, Labiad B, Villemin D. Can. J. Chem. 1993, 71, 90'},{id:"B22",body:'Ozturk G, Gumgum B, Akba O. Synthesis of esters under microwave irradiation using heteropolyacids as catalysts, Catalysis Letters, 2002, 82 (3-4), 233'},{id:"B23",body:'Reilly M K, King R P, Wagner A J, King S M, Microwave-Assisted Esterification: A Discovery-Based Microscale Laboratory Experiment, J. Chem. Educ. 2014, 91, 10, 1706-1709. doi:10.1021/ed400721p'},{id:"B24",body:'Jones G B, Chapman B J, Decarboxylation of indole-2-carboxylic acids: improved procedures, J. Org. Chem. 58, 20, 5558-5559, 1993; doi:10.1021/jo00072a052'},{id:"B25",body:'Cabrera-Rivera F A, Hernández-Vázquez L G, Flores-Sánchez P, Durán-Galván M, Escalante J. Solvent- and Catalyst-Free Microwave-Assisted Decarboxylation of Malonic Acid Derivatives. Green and Sustainable Chemistry, 2017, 7, 270-280, http://www.scirp.org/journal/gsc'},{id:"B26",body:'Varma, R S, Dahiya R.; Kumar S; Clay catalyzed synthesis of imines and enamines under solvent-free conditions using microwave irradiation, Tetrahed. Lett. 1997, 38, 2039-2042'},{id:"B27",body:'Varma R S, Kumar D; Microwave-accelerated three-component condensation reaction on clay: solvent-free synthesis of imidazo [1, 2-a] annulated pyridines, pyrazines and pyrimidines, Tetrahedron lett., 1999 40 (43),7665-7669'},{id:"B28",body:'Mahmood N O, Mohammadgholipour S, Pirbasti F G; Microwave –assisted one-pot three-component synthesis thiazolidinones using KSF@Ni as an efficient heterogeneous catalyst, J of Sulfur Chemistry, 38, 668-678, 2017'},{id:"B29",body:'Garg A, Sarma D, Ali A A; Microwave assisted metal free approach to access 1, 2, 3- triazoles through multicomponent synthesis, Current Research in Green chemistry, 2020, 3, 100013'},{id:"B30",body:'Mandal S, Chhetri K, Bhuyana S, Roy B G, Efficient iron catalyzed ligand-free access to acridines and acridinium ions; Green Chemistry, 2020, 22, 3178-3185; doi:10.1039/D0GC00617C'},{id:"B31",body:'Kremsner J M, Kappe C O; Microwave Assisted Organic synthesis in Near Critical water at 300°C-A proof –of –Concept study, Eup. J Org Chem 3672-3679, 2005'},{id:"B32",body:'Ashry El S H El, Kassem A A, Account of microwave irradiation for accelerating organic reactions, ARKIVOC 2006 (ix) 1-16'},{id:"B33",body:'Naqvi A, Shahnawaaz Md, Rao A V, Seth D S, Sharma N K; Synthesis of Schiff Bases via Environmentally Benign and Energy-Efficient Greener Methodologies E-Journal of Chemistry, 2009, 6(S1), S75-S78'},{id:"B34",body:'Damm M, Glasnov T N, Kappe C O, Org. Process Res. Dev. 14, 215, 2010'},{id:"B35",body:'Sondhi S M, Rani R, Microwave-mediated one step synthesis of tri- and tetracyclic heterocyclic molecules, Green Chemistry Letters and Reviews, 2010, 3(2), 115-120'},{id:"B36",body:'Mete E, Gul H I, Bilginer S, Algul O, Topaloglu M E, Gulluce M, Kazaz C, Synthesis and Antifungal Evaluation of 1-Aryl-2-dimethylaminomethyl-2-propen-1-one Hydrochlorides, Molecules, 2011, 16, 4660-4671; doi:10.3390/molecules16064660'},{id:"B37",body:'Zhu C, Zuo Y, Wang r, Liang B, Yue X, Shang N, Huang L, Chen Y, Du J et al; Discovery of potent cytotoxic ortho-ary chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence. J Med Chem. 2014, 57, 6364-6382'},{id:"B38",body:'Bhat A R, Najar Md H, Dongre R S, Akhter Md S, Microwave assisted synthesis of Knoevenagel Derivatives using water as green solvent, Current Research in Green and Sustainable Chemistry. 2020, 3, 100008'},{id:"B39",body:'Khadijah M. Al-Zaydia, Laila M. Nharia, Rita M. Borika and Mohamed H. Elnagdi, Green technologies in organic synthesis: self-condensation of enamines, enaminones and enaminoesters under microwave irradiation in ionic liquid; Green Chemistry Letters and Reviews, 2010, 3(2), 93-99'},{id:"B40",body:'Brun E, Safer A, Carveaus F, Bourahla K, Lhelgouach J M, Bazureau J P, Villalgordo J M; Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene compounds with aldehydes Catalyzed by Boric acid under Solvent Free Conditions. Molecules. 2015, 20, 11617-11631'},{id:"B41",body:'Zanin L L, Jimenez D E Q, Fonseca L P, Porto A L M, Knoevenagel Condensation Reactions of Cyano Malononitrile-Derivatives Under Microwave Radiation. Current Organic Chemistry, 2018, 22(6). DOI:10.2174/1385272822666180123145819'},{id:"B42",body:'Gupta M, Wakhloo B P, Tetra butyl ammonium bromide mediated Knoevenagel condensation in water: synthesis of cinnamic acids ARKIVOC, (i) 94-98, 2007; DOI: https://doi.org/10.3998/ark.5550190.0008.110'},{id:"B43",body:'de Cozar A, Millan M C, Cebrian C, Prieto P, D’ıaz-Ortiz A, de la Hoza A, Coss’ıob F P, Computational calculations in microwave-assisted organic synthesis (MAOS). Application to cycloaddition reactions. Org. Biomol. Chem., 2010, 8, 1000-1009'},{id:"B44",body:'Roshandel S,Suri S C, Mascischak J C, Rasul G, Prakash G K S, Catalyst and solvent free microwave –assisted synthesis of substituted 1,2,3-triazoles. Green Chem, July 2018, DOI: 101039/c8gc01516c '},{id:"B45",body:'Jha A, Ramarao T A, Expeditious microwave assisted synthesis and bio-evaluation of novel bis (trifluoromethyl) phenyl-triazole-pyridine hybrid analogues by click chemistry approach, Research on Chemical Intermediates. 2018, 44, 585-599, 2018, DOI: 10.1007/s11164-017-3121-2'},{id:"B46",body:'Lee D, Seo Y Ho, Bae J S, Lee S, Lee T I, Gong Y D, Lee T; Bull. Korean Chem. Soc. 2013, 34(8), 2523-2524'},{id:"B47",body:'Hervé G, Christophe Len C, Aqueous microwave-assisted cross-coupling reactions applied to unprotected nucleosides. Front. Chem., 2015, 17; doi:10.3389/fchem.2015.00010'},{id:"B48",body:'Eduardo Mendoza-Pérez E, Vázquez A, Microwave-assisted synthesis of isoindolinones via Pd-mediated tandem coupling reactions, Heterocycl. Commun. 2018; 24(3): 129-133'},{id:"B49",body:'Younis Baqi, Recent Advances in Microwave-Assisted Copper-Catalyzed Cross-Coupling Reactions, Catalysts 2021, 11, 46. doi:10.3390/catal11010046'},{id:"B50",body:'Ouzebla D, Lazrek H B, Smietana M, Vasseur J J, Applications of Microwave in Organic Synthesis; A one –step Synthsis of Ribonucleosides using natural phoshphate as solid catalyst, Chemistry and Material Research, 2013, ,3(4), 84'},{id:"B51",body:'Howe A G R, Maunder R, Morgan D J, Edwards J K, Rapid Microwave-Assisted Polyol Synthesis of TiO2-Supported Ruthenium Catalysts for Levulinic Acid Hydrogenation, Catalysts 2019, 9(9), 748; doi:10.3390/catal9090748'},{id:"B52",body:'Sharma B R, Kumar V, Kumar S, Panesar; Microwave assisted extraction of phytochemicals from Ficus racemosa, Current Research in Green Chemistry, 2020, 3, 100020'},{id:"B53",body:'Jhung S H, Lee J H, Forster P M, Ferey G, Cheetham A K, Chang J S, Microwave Synthesis of Hybrid Inorganic-Organic Porous Materials: Phae-Selective Rapid Crystallization; Chem. Eup. J; 2006, 12, 7899-7905. https: //doi.org/10.1002/chem.200600270]'},{id:"B54",body:'Rajasekhar K K, Ananth V S, Nithiyananthan T S, Hareesh G, Kumar P N, Reddy R S P, International Journal of Chem Tech Research, 2010, 2(1), 592-597'},{id:"B55",body:'Kitchen H J, Vallance S R, Kennedy J L, Tapia-Ruiz N, Carassiti L, Harrison A, Whittaker A G, Drysdale T D, Kingman S W, Gregory D H; Modern Microwave Methods in Solid-State Inorganic Materials Chemistry: From Fundamentals to Manufacturing, Chem. Rev. 2014, 114, 2, 1170-1206'},{id:"B56",body:'Guadino E C, Rinaldi L, Rotolo L, Carnaroglio D, Pirola C, Cravotto G, Heterogeneous Phase Microwave Assisted Reactions under CO2 or CO Pressure; Molecule, 2016, 21, 253'},{id:"B57",body:'Darekara N R, Karalea B K, Akolkara H N, Burungaleb A S, Microwave Assisted Synthesis and Antibacterial Activity of New 1, 3, 4-Thiadiazoles and 1,2,4-Triazoles Derived from 2-{2-[2-(4-Fluorophenyl)-4-methylthiazol-5-yl]-1H-benzo [d]imidazol-1- yl} acetohydrazide Russian Journal of General Chemistry, 2020, 9(9) 1721– 1726'},{id:"B58",body:'Sreeram K J, Nidhin M, Nair B U, Microwave assisted template synthesis of silver nanoparticles, Bull. Mater. Sci., 2008 31(7) 937-942'},{id:"B59",body:'Polshettiwar V, Nadagouda M N, Varma R S, MW-assisted chemistry: a rapid and sustainable route for synthesis of organics and nanomaterials Aust. J. Chem., 2009, 62, 16-26'},{id:"B60",body:'Zhao Y, Zhu J, Hong, Bian J N, Chen H, Microwave-Induced Polyol-Process Synthesis of Copper and Copper Oxide Nanocrystals with Controllable Morphology Eur. J. Inorg. Chem., 2004, 2004, 4072– 4080'},{id:"B61",body:'Huang J, Xia C, Cao L, Zeng X, Facile microwave hydrothermal synthesis of zinc oxide one-dimensional nanostructure with three-dimensional morphology Mater. Sci. Eng. B, 2008, 150, 187-193'},{id:"B62",body:'Wang K, Huang T, Liu H, Zhao Y, Liu H, Sun C, Colloids Surfaces A Physicochem. Eng. Asp., 2008, 325, 21-25'},{id:"B63",body:'Patra C R, Gedanken A, Rapid synthesis of nanoparticles of hexagonal type In2O3 and spherical type Tl2O3 by microwave irradiation, New J. Chem., 2004, 28, 1060-1065'},{id:"B64",body:'Jouhannaud J, Rossignol J, Stuerga D, Rapid synthesis of tin (IV) oxide nanoparticles by microwave induced thermohydrolysis, J. Solid State Chem., 2008, 181, 1439-1444'},{id:"B65",body:'Eliziário S A, Cavalcante L S, Sczancoski J C, Pizani P S, Varela J A, Espinosa J W M, Longo E, Morphology and Photoluminescence of HfO (2) Obtained by Microwave-Hydrothermal Nanoscale Res. Lett., 2009, 4, 1371-1379'},{id:"B66",body:'Zhang H M, Liu J. B, H. Wang, W. X. Zhang, and H. Yan, Rapid microwave-assisted synthesis of phase controlled BiVO4 nanocrystals and research on photocatalytic properties under visible light irradiation J. Nanoparticle Res., 2008, 10, 767-774'},{id:"B67",body:'Zawadzki M, Synthesis of nanosized and microporous zinc aluminate spinel by microwave assisted hydrothermal method (microwave–hydrothermal synthesis of ZnAl2O4) Solid state Sci., 2006, 8, 14-18'},{id:"B68",body:'Nyutu E K, Chen C-H, Dutta P K, Suib S L, Effect of Microwave Frequency on Hydrothermal Synthesis of Nanocrystalline Tetragonal Barium Titanate, J. Phys. Chem. C, 2008, 112, 9659– 9667'},{id:"B69",body:'Moreira M L, Paris E C, do Nascimento G S, Longo V M, Sambrano J R, Mastelaro V R, Bernardi M I B, Andrés J, Varela J A, Longo E, Structural and optical properties of CaTiO3 perovskite-based materials obtained by microwave-assisted hydrothermal synthesis: An experimental and theoretical insigh Acta Mater., 2009, 57, 5174-5185'},{id:"B70",body:'Motshekga S C, Pillai S K, Ray S S, Jalama K, Krause R W M, Recent Trends in the Microwave-Assisted Synthesis of Metal Oxide Nanoparticles Supported on Carbon Nanotubes and Their Applications, Journal of Nanomaterials Volume 2012, Article ID 691503, 15 pages, doi:10.1155/2012/691503'},{id:"B71",body:'Singh D, Rawat D and Isha, Microwave-assisted synthesis of silver nanoparticles from Origanum majorana and Citrus sinensis leaf and their antibacterial activity: a green chemistry approach. Bioresour. Bioprocess. (2016) 3: 14 DOI 10.1186/s40643-016-0090-z'},{id:"B72",body:'Hasanpoor M, Nabavi H F and Aliofkhazraei M, Microwave-assisted Synthesis of Alumina Nanoparticles Using Some Plants Extracts J Nanostruct, 2017, 7(1): 40-46'},{id:"B73",body:'Suchomski C, Breitung B, Witte R, Knapp M, Bauer S, Baumbach T, Reitz C and Brezesinski T. Microwave synthesis of high-quality and uniform 4 nm ZnFe2O4 nanocrystals for application in energy storage and nanomagnetics. Beilstein J. Nanotechnol. 2016, 7, 1350-1360.doi:10.3762/bjnano.7.126'},{id:"B74",body:'Aivazoglou E, Metaxa E, and Hristoforou E, Microwave-assisted synthesis of iron oxide nanoparticles in biocompatible organic environment AIP Advances 8, 048201 (2018); doi:10.1063/1.4994057'},{id:"B75",body:'Zuliani A, Balu A M, Luque R. Efficient and Environmentally Friendly Microwave-Assisted Synthesis of Catalytically Active Magnetic Metallic Ni Nanoparticles. ACS Sustainable Chem. Eng. 2017, 5(12), 11584-11587'},{id:"B76",body:'May-Masnou A, Soler L, Torras M, Salles P, Llorca J and Roig A, Fast and Simple Microwave Synthesis of TiO2/Au Nanoparticles for Gas-Phase Photocatalytic Hydrogen Generation, Front. Chem. 2018, 6: 110. doi:10.3389/fchem.2018.00110'},{id:"B77",body:'Elmaaty T A, El-Nagar Kh, Zaghloul D N, Sayed-Ahmed Kh, ElKadi Sh, Abdelaziz E, Microwave and Nanotechnology Advanced Solutions to Improve Eco-friendly Cotton’s Coloration and Performance Properties. Egypt. J. Chem. 2018, 61 (3) 493-502'},{id:"B78",body:'Xu S, Zhong G, Chen C, Zhou M, Kline D J, Jacob R J, Xie H, He S, Huang Z, Dai J, Brozena A H, Shahbazian-Yassar R, Zachariah M R, Anlage S M, and Hu L, Uniform, Scalable, High-Temperature Microwave Shock for Nanoparticle Synthesis through Defect Engineering, Xu et al., Matter, 2019, 1, 759-769. doi:10.1016/j.matt.2019.05.022'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Anjali Jha",address:"ajhamani@gitam.edu",affiliation:'
Department of Chemistry, GIS, GITAM (deemed to be University) Rushikonda, Visakhapatnam, India
'}],corrections:null},book:{id:"10469",type:"book",title:"Nanofibers",subtitle:"Synthesis, Properties and Applications",fullTitle:"Nanofibers - Synthesis, Properties and Applications",slug:"nanofibers-synthesis-properties-and-applications",publishedDate:"September 15th 2021",bookSignature:"Brajesh Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/10469.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-426-5",printIsbn:"978-1-83968-425-8",pdfIsbn:"978-1-83968-427-2",isAvailableForWebshopOrdering:!0,editors:[{id:"176093",title:"Dr.",name:"Brajesh",middleName:null,surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"419356",title:"Dr.",name:"Tatiana",middleName:null,surname:"Carvalho Reis Martins",email:"tatiana.reis@ufms.br",fullName:"Tatiana Carvalho Reis Martins",slug:"tatiana-carvalho-reis-martins",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"77218",title:"Ethical Deliberation in the Allocation of Respirators and Beds during the Covid-19 Pandemic in Brazil",slug:"ethical-deliberation-in-the-allocation-of-respirators-and-beds-during-the-covid-19-pandemic-in-brazi",abstract:"This chapter proposes a theoretical reflection on the ethical deliberation process in the allocation of beds and respirators, in the light of the Theory of Health Justice, the Accountability for Reasonableness approach and the principle of health equity of the Brazilian Unified Health System (SUS, as per its Portuguese acronym), before the COVID-19 pandemic in Brazil. The pandemic has become a serious threat to health systems, as installed capacity has been exceeded whether in terms of material resources, equipment, technology and human resources. Thus, according to the theory of Accountability for Reasonableness, a fair and deliberative process aims to ensure resource allocation through limits and constraints (reasonableness), but government responsibility derived from human rights must be considered, allowing for health programming (accountability). Faced with this scenario, where the situation will often require us to make choices, this chapter intends to discuss the assumptions for ethical deliberation, taking into account the context of the act and its foreseeable consequences.",signatures:"Maristela Rodrigues Marinho, Sandra Pinto, Juliana Dias Reis Pessalacia, Priscila Kelly da Silva Neto, Marcela Tavares de Souza and Tatiana Carvalho Reis Martins",authors:[{id:"224763",title:"Dr.",name:"Juliana",surname:"Dias Reis Pessalacia",fullName:"Juliana Dias Reis Pessalacia",slug:"juliana-dias-reis-pessalacia",email:"juliana@pessalacia.com.br"},{id:"352905",title:"Mrs.",name:"Priscila",surname:"Kelly da Silva Neto",fullName:"Priscila Kelly da Silva Neto",slug:"priscila-kelly-da-silva-neto",email:"priscila.baldonado@gmail.com"},{id:"353826",title:"Dr.",name:"Maristela",surname:"Rodrigues Marinho",fullName:"Maristela Rodrigues Marinho",slug:"maristela-rodrigues-marinho",email:"mmaristelammarinho@gmail.com"},{id:"353830",title:"Ms.",name:"Sandra",surname:"Pinto",fullName:"Sandra Pinto",slug:"sandra-pinto",email:"nfpinto@hotmail.com"},{id:"419355",title:"Dr.",name:"Marcela",surname:"Tavares De Souza",fullName:"Marcela Tavares De Souza",slug:"marcela-tavares-de-souza",email:"mtavares51@gmail.com"},{id:"419356",title:"Dr.",name:"Tatiana",surname:"Carvalho Reis Martins",fullName:"Tatiana Carvalho Reis Martins",slug:"tatiana-carvalho-reis-martins",email:"tatiana.reis@ufms.br"}],book:{id:"10705",title:"Healthcare Access",slug:"healthcare-access",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"113452",title:"Associate Prof.",name:"Hülya",surname:"Gül",slug:"hulya-gul",fullName:"Hülya Gül",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Istanbul University",institutionURL:null,country:{name:"Turkey"}}},{id:"226652",title:"Dr.",name:"Terry J.",surname:"Ellapen",slug:"terry-j.-ellapen",fullName:"Terry J. Ellapen",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"233596",title:"Prof.",name:"Yvonne",surname:"Paul",slug:"yvonne-paul",fullName:"Yvonne Paul",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"268981",title:"Ph.D.",name:"Neta",surname:"Kela-Madar",slug:"neta-kela-madar",fullName:"Neta Kela-Madar",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"318369",title:"Dr.",name:"Esra",surname:"Yıldız",slug:"esra-yildiz",fullName:"Esra Yıldız",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ege University",institutionURL:null,country:{name:"Turkey"}}},{id:"353727",title:"Associate Prof.",name:"Genesis",surname:"Chorwe-Sungani",slug:"genesis-chorwe-sungani",fullName:"Genesis Chorwe-Sungani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"414123",title:"Dr.",name:"Takalani C",surname:"Muluvhu",slug:"takalani-c-muluvhu",fullName:"Takalani C Muluvhu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Tshwane University of Technology",institutionURL:null,country:{name:"South Africa"}}},{id:"414124",title:"Mr.",name:"Makwena B.",surname:"Ntjana",slug:"makwena-b.-ntjana",fullName:"Makwena B. Ntjana",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Tshwane University of Technology",institutionURL:null,country:{name:"South Africa"}}},{id:"419861",title:"Prof.",name:"Yüksel",surname:"Atay",slug:"yuksel-atay",fullName:"Yüksel Atay",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"419862",title:"Prof.",name:"Oktay",surname:"Pamuk",slug:"oktay-pamuk",fullName:"Oktay Pamuk",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ege University",institutionURL:null,country:{name:"Turkey"}}}]},generic:{page:{slug:"about-open-access",title:"About Open Access and Open Science",intro:"
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\n
Carlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"
Open Access background
\\n\\n
The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\n
IntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\n
At IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n
“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\n
Open Access Standards followed by IntechOpen
\\n\\n
OAI-PMH
\\n\\n
As a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\n
License
\\n\\n
Book chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\\n\\n
Peer Review Policies
\\n\\n
All scientific works are Peer Reviewed prior to publishing. Read more
\\n\\n
OA Publishing Fees
\\n\\n
The Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\n
Digital Archiving Policy
\\n\\n
IntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\n
Open Science
\\n\\n
Open Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\n
Open Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\\n\\n
Open Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\\n\\n
\\n\\t
Promoting open and publicly accessible education tools
\\n\\t
Transparency in experimental methodology, observation, and collection of data
\\n\\t
Reproducible research data and re-analysis
\\n\\t
Public availability and re-usability of scientific data
\\n\\t
Public accessibility and transparency of scientific communication
\\n\\t
Transparent peer-review and publishing practices
\\n\\t
Using web-based tools to facilitate scientific collaboration
\\n\\t
Supporting exchange of knowledge and research materials between disciplines
\\n\\t
Supporting exchange of knowledge and research materials between scientific communities and industry.
\\n
\\n\\n
We aim at improving the quality and availability of scholarly communication by promoting and practicing:
The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\n
IntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\n
At IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n
“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\n
Open Access Standards followed by IntechOpen
\n\n
OAI-PMH
\n\n
As a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\n
License
\n\n
Book chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\n
Peer Review Policies
\n\n
All scientific works are Peer Reviewed prior to publishing. Read more
\n\n
OA Publishing Fees
\n\n
The Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\n
Digital Archiving Policy
\n\n
IntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\n
Open Science
\n\n
Open Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\n
Open Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\n
Open Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\n
\n\t
Promoting open and publicly accessible education tools
\n\t
Transparency in experimental methodology, observation, and collection of data
\n\t
Reproducible research data and re-analysis
\n\t
Public availability and re-usability of scientific data
\n\t
Public accessibility and transparency of scientific communication
\n\t
Transparent peer-review and publishing practices
\n\t
Using web-based tools to facilitate scientific collaboration
\n\t
Supporting exchange of knowledge and research materials between disciplines
\n\t
Supporting exchange of knowledge and research materials between scientific communities and industry.
\n
\n\n
We aim at improving the quality and availability of scholarly communication by promoting and practicing:
\n\n
\n\t
Open Access
\n\t
Open Data
\n\t
Open Metrics and Impact
\n\t
Open Source
\n
\n\n
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6602},{group:"region",caption:"Middle and South America",value:2,count:5908},{group:"region",caption:"Africa",value:3,count:2400},{group:"region",caption:"Asia",value:4,count:12542},{group:"region",caption:"Australia and Oceania",value:5,count:1008},{group:"region",caption:"Europe",value:6,count:17561}],offset:12,limit:12,total:132766},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish",topicId:"8,9,10,11,14,15,20,22,24"},books:[{type:"book",id:"11561",title:"Zeolite From Wastes - New Perspectives on Innovative Resources and Their Valorization Process",subtitle:null,isOpenForSubmission:!0,hash:"3ed0dfd842de9cd1143212415903e6ad",slug:null,bookSignature:"Dr. Claudia Belviso",coverURL:"https://cdn.intechopen.com/books/images_new/11561.jpg",editedByType:null,editors:[{id:"61457",title:"Dr.",name:"Claudia",surname:"Belviso",slug:"claudia-belviso",fullName:"Claudia Belviso"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11470",title:"Graphene - Recent Advances, Future Perspective and Applied Applications",subtitle:null,isOpenForSubmission:!0,hash:"409e022e3baf48795e816576a6ee66e3",slug:null,bookSignature:"Dr. Mujtaba Ikram, Dr. Asghari Maqsood and Dr. Aneeqa Bashir",coverURL:"https://cdn.intechopen.com/books/images_new/11470.jpg",editedByType:null,editors:[{id:"286820",title:"Dr.",name:"Mujtaba",surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11445",title:"Multi-Agent Technologies and Machine Learning",subtitle:null,isOpenForSubmission:!0,hash:"d980826615baa6e33456e2a79064c5e8",slug:null,bookSignature:"Prof. Igor Sheremet",coverURL:"https://cdn.intechopen.com/books/images_new/11445.jpg",editedByType:null,editors:[{id:"265237",title:"Prof.",name:"Igor",surname:"Sheremet",slug:"igor-sheremet",fullName:"Igor Sheremet"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11519",title:"Vibration Monitoring and Analysis - Recent Advances",subtitle:null,isOpenForSubmission:!0,hash:"f0d2d82a5c1a49020abf39dc8aabd89d",slug:null,bookSignature:"Dr.Ing. Louay Yousuf",coverURL:"https://cdn.intechopen.com/books/images_new/11519.jpg",editedByType:null,editors:[{id:"322417",title:"Dr.Ing.",name:"Louay",surname:"Yousuf",slug:"louay-yousuf",fullName:"Louay Yousuf"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11468",title:"High Entropy Alloys - Recent Advances, New Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"3b4ef3ce01f8f9b113dc28ac847b8c0d",slug:null,bookSignature:"Prof. Yong A Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/11468.jpg",editedByType:null,editors:[{id:"203937",title:"Prof.",name:"Yong",surname:"Zhang",slug:"yong-zhang",fullName:"Yong Zhang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11525",title:"Wood Industry - Past, Present and Future Outlook",subtitle:null,isOpenForSubmission:!0,hash:"ccb74142053c89e0e572ac1c5d717a11",slug:null,bookSignature:"Prof. Guanben Du and Dr. Xiaojian Zhou",coverURL:"https://cdn.intechopen.com/books/images_new/11525.jpg",editedByType:null,editors:[{id:"291315",title:"Prof.",name:"Guanben",surname:"Du",slug:"guanben-du",fullName:"Guanben Du"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11484",title:"Thin Film Deposition - Fundamentals, Processes, and Applications",subtitle:null,isOpenForSubmission:!0,hash:"9c10a55203c2f0f7d47c743e6cfa2492",slug:null,bookSignature:"Dr. Dongfang Yang",coverURL:"https://cdn.intechopen.com/books/images_new/11484.jpg",editedByType:null,editors:[{id:"177814",title:"Dr.",name:"Dongfang",surname:"Yang",slug:"dongfang-yang",fullName:"Dongfang Yang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11512",title:"Photodetectors - Recent Advances, New Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"01d4be8e37c9bf12fd8dcb67c135b29b",slug:null,bookSignature:"Prof. Kuan W. A. Chee",coverURL:"https://cdn.intechopen.com/books/images_new/11512.jpg",editedByType:null,editors:[{id:"206271",title:"Prof.",name:"Kuan",surname:"Chee",slug:"kuan-chee",fullName:"Kuan Chee"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11121",title:"Crystal Growth - Technologies and Applications",subtitle:null,isOpenForSubmission:!0,hash:"81f076fab2acb567946aeaa4b7281fc1",slug:null,bookSignature:"Dr. Riadh Marzouki",coverURL:"https://cdn.intechopen.com/books/images_new/11121.jpg",editedByType:null,editors:[{id:"300527",title:"Dr.",name:"Riadh",surname:"Marzouki",slug:"riadh-marzouki",fullName:"Riadh Marzouki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11544",title:"Failure Analysis",subtitle:null,isOpenForSubmission:!0,hash:"4ff5277ca99c7d717cc47be22b0d92de",slug:null,bookSignature:"Dr. Gobinath Ravindran",coverURL:"https://cdn.intechopen.com/books/images_new/11544.jpg",editedByType:null,editors:[{id:"145364",title:"Dr.",name:"Gobinath",surname:"Ravindran",slug:"gobinath-ravindran",fullName:"Gobinath Ravindran"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11490",title:"Advances in Plate Tectonics",subtitle:null,isOpenForSubmission:!0,hash:"412f2e209ff259650a5a1c7df151e3a7",slug:null,bookSignature:"Dr. Gaurav D. Chauhan, Dr. Subhash Bhandari and Dr. M. G. Thakkar",coverURL:"https://cdn.intechopen.com/books/images_new/11490.jpg",editedByType:null,editors:[{id:"239938",title:"Dr.",name:"Gaurav",surname:"Chauhan",slug:"gaurav-chauhan",fullName:"Gaurav Chauhan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11534",title:"Renewable Energy - Recent Advances",subtitle:null,isOpenForSubmission:!0,hash:"170d1a20a1925b6a29c6146f12ade4a5",slug:null,bookSignature:"Prof. Ahmed M. Nahhas",coverURL:"https://cdn.intechopen.com/books/images_new/11534.jpg",editedByType:null,editors:[{id:"140058",title:"Prof.",name:"Ahmed",surname:"Nahhas",slug:"ahmed-nahhas",fullName:"Ahmed Nahhas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:43},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:24},{group:"topic",caption:"Computer and Information Science",value:9,count:19},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:61},{group:"topic",caption:"Environmental Sciences",value:12,count:9},{group:"topic",caption:"Immunology and Microbiology",value:13,count:10},{group:"topic",caption:"Materials Science",value:14,count:29},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:124},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:12},{group:"topic",caption:"Psychology",value:21,count:9},{group:"topic",caption:"Robotics",value:22,count:3},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:3}],offset:12,limit:12,total:176},popularBooks:{featuredBooks:[],offset:0,limit:12,total:null},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[],latestBooks:[]},subject:{topic:{id:"228",title:"Optics and Lasers",slug:"optics-and-lasers",parent:{id:"20",title:"Physics",slug:"physics"},numberOfBooks:77,numberOfSeries:0,numberOfAuthorsAndEditors:2175,numberOfWosCitations:3299,numberOfCrossrefCitations:1375,numberOfDimensionsCitations:3105,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"228",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10672",title:"Nonlinear Optics",subtitle:"Nonlinear Nanophotonics and Novel Materials for Nonlinear Optics",isOpenForSubmission:!1,hash:"cfe87b713a8bee22c19361b86b03d506",slug:"nonlinear-optics-nonlinear-nanophotonics-and-novel-materials-for-nonlinear-optics",bookSignature:"Boris I. Lembrikov",coverURL:"https://cdn.intechopen.com/books/images_new/10672.jpg",editedByType:"Edited by",editors:[{id:"2359",title:"Dr.",name:"Boris I.",middleName:"I.",surname:"Lembrikov",slug:"boris-i.-lembrikov",fullName:"Boris I. Lembrikov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9655",title:"Bioluminescence",subtitle:"Technology and Biology",isOpenForSubmission:!1,hash:"26b9e7dade717a5ffdc2dbcfaa1ea43d",slug:"bioluminescence-technology-and-biology",bookSignature:"Hirobumi Suzuki and Katsunori Ogoh",coverURL:"https://cdn.intechopen.com/books/images_new/9655.jpg",editedByType:"Edited by",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10767",title:"Fiber Optics",subtitle:"Technology and Applications",isOpenForSubmission:!1,hash:"f6624b8ef72a4a369383a4b719bba2a4",slug:"fiber-optics-technology-and-applications",bookSignature:"Guillermo Huerta-Cuellar",coverURL:"https://cdn.intechopen.com/books/images_new/10767.jpg",editedByType:"Edited by",editors:[{id:"237167",title:"Dr.",name:"Guillermo",middleName:null,surname:"Huerta-Cuellar",slug:"guillermo-huerta-cuellar",fullName:"Guillermo Huerta-Cuellar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10017",title:"Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"e20f25706d03f0c52ac852f7fa2375e7",slug:"optoelectronics",bookSignature:"Mike Haidar Shahine",coverURL:"https://cdn.intechopen.com/books/images_new/10017.jpg",editedByType:"Edited by",editors:[{id:"102474",title:"Dr.",name:"Mike Haidar",middleName:null,surname:"Shahine",slug:"mike-haidar-shahine",fullName:"Mike Haidar Shahine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10075",title:"Nonlinear Optics",subtitle:"From Solitons to Similaritons",isOpenForSubmission:!1,hash:"b034b2a060292c8511359aec0db1002c",slug:"nonlinear-optics-from-solitons-to-similaritons",bookSignature:"İlkay Bakırtaş and Nalan Antar",coverURL:"https://cdn.intechopen.com/books/images_new/10075.jpg",editedByType:"Edited by",editors:[{id:"186388",title:"Prof.",name:"İlkay",middleName:null,surname:"Bakırtaş",slug:"ilkay-bakirtas",fullName:"İlkay Bakırtaş"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9211",title:"Single Photon Manipulation",subtitle:null,isOpenForSubmission:!1,hash:"567ddcc14b68fa14e54df3bce2f51acc",slug:"single-photon-manipulation",bookSignature:"Keyu Xia",coverURL:"https://cdn.intechopen.com/books/images_new/9211.jpg",editedByType:"Edited by",editors:[{id:"210723",title:"Prof.",name:"Keyu",middleName:null,surname:"Xia",slug:"keyu-xia",fullName:"Keyu Xia"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7965",title:"Liquid Crystals and Display Technology",subtitle:null,isOpenForSubmission:!1,hash:"eb83772cea6200bdd685b8a1b93ee35d",slug:"liquid-crystals-and-display-technology",bookSignature:"Morteza Sasani Ghamsari and Irina Carlescu",coverURL:"https://cdn.intechopen.com/books/images_new/7965.jpg",editedByType:"Edited by",editors:[{id:"64949",title:"Prof.",name:"Morteza",middleName:null,surname:"Sasani Ghamsari",slug:"morteza-sasani-ghamsari",fullName:"Morteza Sasani Ghamsari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8527",title:"Luminescence",subtitle:"OLED Technology and Applications",isOpenForSubmission:!1,hash:"dbdf51e72104f9e570cc0f1ea6c02a9e",slug:"luminescence-oled-technology-and-applications",bookSignature:"Sergei Pyshkin",coverURL:"https://cdn.intechopen.com/books/images_new/8527.jpg",editedByType:"Edited by",editors:[{id:"43016",title:"Prof.",name:"Sergei",middleName:"L.",surname:"Pyshkin",slug:"sergei-pyshkin",fullName:"Sergei Pyshkin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8873",title:"Optical Coherence Tomography and Its Non-medical Applications",subtitle:null,isOpenForSubmission:!1,hash:"04048c4d925e4a7256014a26cf19c40c",slug:"optical-coherence-tomography-and-its-non-medical-applications",bookSignature:"Michael R. Wang",coverURL:"https://cdn.intechopen.com/books/images_new/8873.jpg",editedByType:"Edited by",editors:[{id:"6356",title:"Dr.",name:"Michael",middleName:null,surname:"Wang",slug:"michael-wang",fullName:"Michael Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9272",title:"Optical Fiber Applications",subtitle:null,isOpenForSubmission:!1,hash:"dd156cc0568d8a4204d9f13609d8ff9e",slug:"optical-fiber-applications",bookSignature:"Guillermo Huerta-Cuellar and Roghayeh Imani",coverURL:"https://cdn.intechopen.com/books/images_new/9272.jpg",editedByType:"Edited by",editors:[{id:"237167",title:"Dr.",name:"Guillermo",middleName:null,surname:"Huerta-Cuellar",slug:"guillermo-huerta-cuellar",fullName:"Guillermo Huerta-Cuellar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7515",title:"Photonic Crystals",subtitle:"A Glimpse of the Current Research Trends",isOpenForSubmission:!1,hash:"1dcab6021cb88bdb66e9588e2fc24d19",slug:"photonic-crystals-a-glimpse-of-the-current-research-trends",bookSignature:"Pankaj Kumar Choudhury",coverURL:"https://cdn.intechopen.com/books/images_new/7515.jpg",editedByType:"Edited by",editors:[{id:"205744",title:"Dr.",name:"Pankaj",middleName:null,surname:"Kumar Choudhury",slug:"pankaj-kumar-choudhury",fullName:"Pankaj Kumar Choudhury"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7682",title:"Holographic Materials and Applications",subtitle:null,isOpenForSubmission:!1,hash:"ca1b913a04397b7c3477135969230103",slug:"holographic-materials-and-applications",bookSignature:"Manoj Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/7682.jpg",editedByType:"Edited by",editors:[{id:"191886",title:"Dr.",name:"Manoj",middleName:null,surname:"Kumar",slug:"manoj-kumar",fullName:"Manoj Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:77,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"49652",doi:"10.5772/61720",title:"Sample Preparations for Scanning Electron Microscopy – Life Sciences",slug:"sample-preparations-for-scanning-electron-microscopy-life-sciences",totalDownloads:8707,totalCrossrefCites:36,totalDimensionsCites:83,abstract:"Sample preparations are essential in scanning electron microscopy. Flawed sample preparations can undermine the quality of results and lead to false conclusions. Thus, the aim of this chapter is to equip researchers, post graduate students and technicians with essential knowledge required to prepare samples for scanning electron microscopy (SEM) investigations in the life sciences.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mogana Das Murtey and Patchamuthu Ramasamy",authors:[{id:"176330",title:"Dr.",name:"Mogana",middleName:"Das",surname:"Murtey",slug:"mogana-murtey",fullName:"Mogana Murtey"},{id:"181159",title:"Mr.",name:"Patchamuthu",middleName:null,surname:"Ramasamy",slug:"patchamuthu-ramasamy",fullName:"Patchamuthu Ramasamy"}]},{id:"30963",doi:"10.5772/34176",title:"Microstructural and Mineralogical Characterization of Clay Stabilized Using Calcium-Based Stabilizers",slug:"microstructural-and-mineralogical-characterization-of-clay-stabilized-using-calcium-based-stabilizer",totalDownloads:6777,totalCrossrefCites:29,totalDimensionsCites:48,abstract:null,book:{id:"1505",slug:"scanning-electron-microscopy",title:"Scanning Electron Microscopy",fullTitle:"Scanning Electron Microscopy"},signatures:"Pranshoo Solanki and Musharraf Zaman",authors:[{id:"20942",title:"Prof.",name:"Pranshoo",middleName:null,surname:"Solanki",slug:"pranshoo-solanki",fullName:"Pranshoo Solanki"},{id:"20945",title:"Prof.",name:"Musharraf",middleName:null,surname:"Zaman",slug:"musharraf-zaman",fullName:"Musharraf Zaman"}]},{id:"26791",doi:"10.5772/28067",title:"Optical Vortices in a Fiber: Mode Division Multiplexing and Multimode Self-Imaging",slug:"optical-vortices-in-a-fiber-mode-division-multiplexing-and-multimode-self-reproducing",totalDownloads:4515,totalCrossrefCites:29,totalDimensionsCites:47,abstract:null,book:{id:"2018",slug:"recent-progress-in-optical-fiber-research",title:"Recent Progress in Optical Fiber Research",fullTitle:"Recent Progress in Optical Fiber Research"},signatures:"S.N. Khonina, N.L. Kazanskiy and V.A. Soifer",authors:[{id:"72613",title:"Prof.",name:"Svetlana",middleName:null,surname:"Khonina",slug:"svetlana-khonina",fullName:"Svetlana Khonina"}]},{id:"42033",doi:"10.5772/53897",title:"Photonic Crystals for Optical Sensing: A Review",slug:"photonic-crystals-for-optical-sensing-a-review",totalDownloads:5982,totalCrossrefCites:23,totalDimensionsCites:42,abstract:null,book:{id:"3486",slug:"advances-in-photonic-crystals",title:"Advances in Photonic Crystals",fullTitle:"Advances in Photonic Crystals"},signatures:"Benedetto Troia, Antonia Paolicelli, Francesco De Leonardis and Vittorio M. N. Passaro",authors:[{id:"83905",title:"Prof.",name:"Vittorio",middleName:"M. N.",surname:"Passaro",slug:"vittorio-passaro",fullName:"Vittorio Passaro"}]},{id:"38815",doi:"10.5772/51665",title:"Advances in Infrared Detector Array Technology",slug:"advances-in-infrared-detector-array-technology",totalDownloads:10665,totalCrossrefCites:12,totalDimensionsCites:41,abstract:null,book:{id:"3166",slug:"optoelectronics-advanced-materials-and-devices",title:"Optoelectronics",fullTitle:"Optoelectronics - Advanced Materials and Devices"},signatures:"Nibir K. Dhar, Ravi Dat and Ashok K. Sood",authors:[{id:"23657",title:"Dr.",name:"Ashok K.",middleName:"K",surname:"Sood",slug:"ashok-k.-sood",fullName:"Ashok K. Sood"},{id:"60603",title:"Dr.",name:"Nibir",middleName:null,surname:"Dhar",slug:"nibir-dhar",fullName:"Nibir Dhar"}]}],mostDownloadedChaptersLast30Days:[{id:"52164",title:"An Overview on Quantum Cascade Lasers: Origins and Development",slug:"an-overview-on-quantum-cascade-lasers-origins-and-development",totalDownloads:3177,totalCrossrefCites:1,totalDimensionsCites:10,abstract:"This chapter presents an introductory review on quantum cascade lasers (QCLs). An overview is prefaced, including a brief description of their beginnings and operating basics. Materials used, as well as growth methods, are also described. The possibility of developing GaN-based QCLs is also shown. Summarizing, the applications of these structures cover a broad range, including spectroscopy, free-space communication, as well as applications to near-space radar and chemical/biological detection. Furthermore, a number of state-of-the-art applications are described in different fields, and finally a brief assessment of the possibilities of volume production and the overall state of the art in QCLs research are elaborated.",book:{id:"5389",slug:"quantum-cascade-lasers",title:"Quantum Cascade Lasers",fullTitle:"Quantum Cascade Lasers"},signatures:"Raúl Pecharromán-Gallego",authors:[{id:"188866",title:"Dr.",name:"Raúl",middleName:null,surname:"Pecharromán-Gallego",slug:"raul-pecharroman-gallego",fullName:"Raúl Pecharromán-Gallego"}]},{id:"49526",title:"Focused Ion Beams (FIB) — Novel Methodologies and Recent Applications for Multidisciplinary Sciences",slug:"focused-ion-beams-fib-novel-methodologies-and-recent-applications-for-multidisciplinary-sciences",totalDownloads:4272,totalCrossrefCites:4,totalDimensionsCites:9,abstract:"Considered as the newest field of electron microscopy, focused ion beam (FIB) technologies are used in many fields of science for site-specific analysis, imaging, milling, deposition, micromachining, and manipulation. Dual-beam platforms, combining a high-resolution scanning electron microscope (HR-SEM) and an FIB column, additionally equipped with precursor-based gas injection systems (GIS), micromanipulators, and chemical analysis tools (such as energy-dispersive spectra (EDS) or wavelength-dispersive spectra (WDS)), serve as multifunctional tools for direct lithography in terms of nano-machining and nano-prototyping, while advanced specimen preparation for transmission electron microscopy (TEM) can practically be carried out with ultrahigh precision. Especially, when hard materials and material systems with hard substrates are concerned, FIB is the only technique for site-specific micro- and nanostructuring. Moreover, FIB sectioning and sampling techniques are frequently used for revealing the structural and morphological distribution of material systems with three-dimensional (3D) network at micro-/nanoscale.This book chapter includes many examples on conventional and novel processes of FIB technologies, ranging from analysis of semiconductors to electron tomography-based imaging of hard materials such as nanoporous ceramics and composites. In addition, recent studies concerning the active use of dual-beam platforms are mentioned",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Meltem Sezen",authors:[{id:"176338",title:"Associate Prof.",name:"Meltem",middleName:null,surname:"Sezen",slug:"meltem-sezen",fullName:"Meltem Sezen"}]},{id:"50866",title:"Effects of Different Laser Pulse Regimes (Nanosecond, Picosecond and Femtosecond) on the Ablation of Materials for Production of Nanoparticles in Liquid Solution",slug:"effects-of-different-laser-pulse-regimes-nanosecond-picosecond-and-femtosecond-on-the-ablation-of-ma",totalDownloads:6031,totalCrossrefCites:10,totalDimensionsCites:32,abstract:"Ultra-short laser pulse interaction with materials has received much attention from researchers in micro- and nanomachining, especially for the generation of nanoparticles in liquid environments, because of the straightforward method and direct application for organic solvents. In addition, the colloidal nanoparticles produced by laser ablation have very high purity—they are free from surfactants and reaction products or by-products. In this chapter, nanosecond, picosecond and femtosecond laser pulse durations are compared in laser material processing. Due to the unique properties of the short and ultra-short laser pulse durations in material processing, they are more apparent in the production of precision material processing and generation of nanoparticles in liquid environments.",book:{id:"5236",slug:"high-energy-and-short-pulse-lasers",title:"High Energy and Short Pulse Lasers",fullTitle:"High Energy and Short Pulse Lasers"},signatures:"Abubaker Hassan Hamad",authors:[{id:"183494",title:"Dr.",name:"Abubaker",middleName:"Hassan",surname:"Hamad",slug:"abubaker-hamad",fullName:"Abubaker Hamad"}]},{id:"49537",title:"Electron Diffraction",slug:"electron-diffraction",totalDownloads:10069,totalCrossrefCites:9,totalDimensionsCites:30,abstract:"Electron microscopes are usually supplied with equipment for obtaining diffraction patterns and micrographs from the same area of a specimen and the best results are attained if the complete use is to be made of these combined facilities. Electron diffraction patterns are used to obtain quantitative data including phase identification, orientation relationship and crystal defects in materials, etc. At first, a general introduction including a geometrical and quantitative approach to electron diffraction from a crystalline specimen, the reciprocal lattice and electron diffraction in the electron microscope are presented. The scattering process by an individual atom as well as a crystal, the Bragg law, Laue conditions and structure factor are also discussed. Types of diffraction patterns such as ring pattern, spot pattern and Kikuchi pattern, and general and unique indexing diffraction patterns are explained. The procedure for indexing simple, complicated and imperfect patterns as well as Kikuchi lines and a combination of Kikuchi lines and spots is outlined. The known and unknown materials are identified by indexing patterns. Practical comparisons between various methods of analysing diffraction patterns are also described. The basic diffraction patterns and the fine structure in the patterns including specimen tilting experiments, orientation relationship determination, phase identification, twinning, second phases, crystallographic information, dislocation, preferred orientation and texture, extra spots and streaks are described in detail. Finally, electron diffraction patterns of new materials are investigated.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mohsen Asadi Asadabad and Mohammad Jafari Eskandari",authors:[{id:"176352",title:"Dr.",name:"Mohsen",middleName:null,surname:"Asadi Asadabad",slug:"mohsen-asadi-asadabad",fullName:"Mohsen Asadi Asadabad"},{id:"177600",title:"Dr.",name:"Mohammad",middleName:null,surname:"Jafari Eskandari",slug:"mohammad-jafari-eskandari",fullName:"Mohammad Jafari Eskandari"}]},{id:"38543",title:"Application of FTIR Spectroscopy in Environmental Studies",slug:"application-of-ftir-spectroscopy-in-environmental-studies",totalDownloads:27612,totalCrossrefCites:9,totalDimensionsCites:40,abstract:null,book:{id:"2397",slug:"advanced-aspects-of-spectroscopy",title:"Advanced Aspects of Spectroscopy",fullTitle:"Advanced Aspects of Spectroscopy"},signatures:"Claudia Maria Simonescu",authors:[{id:"142381",title:"Dr.",name:"Claudia Maria",middleName:null,surname:"Simonescu",slug:"claudia-maria-simonescu",fullName:"Claudia Maria Simonescu"}]}],onlineFirstChaptersFilter:{topicId:"228",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 24th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:50,paginationItems:[{id:"81927",title:"Purinergic System in Immune Response",doi:"10.5772/intechopen.104485",signatures:"Yerly Magnolia Useche Salvador",slug:"purinergic-system-in-immune-response",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science and Technology from the Department of Chemistry, National University of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013. She relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the National Institute of Fundamental Studies from April 2013 to October 2016. She was a senior lecturer on a temporary basis at the Department of Food Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is currently Deputy Principal of the Australian College of Business and Technology – Kandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI) Ambassador to Sri Lanka.",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. Dr. Suzuki currently serves as a visiting researcher at Kogakuin University, Japan, and also a vice president of the Japan Firefly Society.",institutionString:"Kogakuin University",institution:null}]}]},openForSubmissionBooks:{},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. Neiva",profilePictureURL:"https://mts.intechopen.com/storage/users/213786/images/system/213786.png",institutionString:null,institution:{name:"University of Beira Interior",institutionURL:null,country:{name:"Portugal"}}},{id:"39275",title:"Prof.",name:"Herbert Ryan",middleName:null,surname:"Marini",slug:"herbert-ryan-marini",fullName:"Herbert Ryan Marini",profilePictureURL:"https://mts.intechopen.com/storage/users/39275/images/9459_n.jpg",institutionString:null,institution:{name:"University of Messina",institutionURL:null,country:{name:"Italy"}}},{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",institutionString:null,institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}]},onlineFirstChapters:{},publishedBooks:{},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/419356",hash:"",query:{},params:{id:"419356"},fullPath:"/profiles/419356",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var t;(t=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(t)}()