Non-Rehabilitation Studies using Telestroke in Stroke Survivors
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"7221",leadTitle:null,fullTitle:"Atomic-force Microscopy and Its Applications",title:"Atomic-force Microscopy and Its Applications",subtitle:null,reviewType:"peer-reviewed",abstract:"Atomic force microscopy is a surface analytical technique used in air, liquids or a vacuum to generate very high-resolution topographic images of a surface, down to atomic resolution. This book is not only for students but also for professional engineers who are working in the industry as well as specialists. This book aims to provide the reader with a comprehensive overview of the new trends, research results and development of atomic force microscopy. The chapters for this book have been written by respected and well-known researchers and specialists from different countries. We hope that after studying this book, you will have objective knowledge about the possible uses of atomic force microscopy in many scientific aspects of our civilisation.",isbn:"978-1-78985-170-0",printIsbn:"978-1-78985-169-4",pdfIsbn:"978-1-83881-776-3",doi:"10.5772/intechopen.74139",price:119,priceEur:129,priceUsd:155,slug:"atomic-force-microscopy-and-its-applications",numberOfPages:114,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"2320402a229f880b0be7c73b247ebcf4",bookSignature:"Tomasz Tański, Marcin Staszuk and Bogusław Ziębowicz",publishedDate:"January 30th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7221.jpg",numberOfDownloads:6471,numberOfWosCitations:5,numberOfCrossrefCitations:7,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:12,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:24,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 22nd 2018",dateEndSecondStepPublish:"February 12th 2018",dateEndThirdStepPublish:"April 13th 2018",dateEndFourthStepPublish:"July 2nd 2018",dateEndFifthStepPublish:"August 31st 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"15700",title:"Prof.",name:"Tomasz Arkadiusz",middleName:null,surname:"Tański",slug:"tomasz-arkadiusz-tanski",fullName:"Tomasz Arkadiusz Tański",profilePictureURL:"https://mts.intechopen.com/storage/users/15700/images/system/15700.png",biography:"Prof. Tomasz Tański is the Head of the Department of Engineering Materials and Biomaterials, Silesian University of Technology, Gliwice, Poland, and a member of the Polish Academy of Sciences, Committee of Metallurgy. He is a specialist in non-ferrous alloys, composite materials, and nanostructured, manufacturing engineering. He has authored or co-authored more than 400 scientific publications worldwide, including 15 monographs and books and more than 116 publications on the Thomson Scientific Master Journal List. He has won twenty national and international awards. He is and has been a supervisor or contractor for more than fifteen research and didactic projects in Poland and abroad. He is a reviewer and promoter of numerous scientific papers, including eight doctoral theses in the field of nanotechnology and materials.",institutionString:"Silesian University of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"10",totalChapterViews:"0",totalEditedBooks:"7",institution:{name:"Silesian University of Technology",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"241789",title:"Dr.",name:"Marcin",middleName:null,surname:"Staszuk",slug:"marcin-staszuk",fullName:"Marcin Staszuk",profilePictureURL:"https://mts.intechopen.com/storage/users/241789/images/8209_n.jpg",biography:"Dr. Marcin Staszuk obtained a doctoral degree from the Silesian University of Technology in 2010, in Technical Sciences in the field of Materials Engineering. He works as an Assistant Professor at the Institute of Engineering Materials and Biomedical Engineering at the Silesian University of Technology. His scientific interests include surface engineering, tool materials, light metal alloys and modern materials investigation methods. He is the author and co-author of numerous international scientific works, including 22 publications from the Philadelphia list. He has completed numerous scientific and didactic internships in Portugal, Greece and the Czech Republic. At the International Inventions and Innovation Exhibitions, he won three gold medals. He is the supervisor of numerous MA theses and the auxiliary supervisor in the PhD thesis.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"241788",title:"Dr.",name:"Boguslaw",middleName:null,surname:"Ziebowicz",slug:"boguslaw-ziebowicz",fullName:"Boguslaw Ziebowicz",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:'Dr. Bogusław Ziębowicz obtained a doctoral degree in technical sciences in the field of Materials Science at the Silesian University of Technology. The subject of his doctoral thesis was \\"Structure and properties of composite materials composed of nanocrystalline powders Fe73,5Cu1Nb3Si13,5B9 and polyethylene”. With the aim of further scientific activity, he continued the work on dental materials - nanostructured layers on dental components. Currently, his scientific interests include primary uses of an atomic force microscope in the study of the surface of dental materials. He enjoys working with students and he is supervisor of the Student Scientific Circle Nanotechnology and functional materials. During his scientific activity, he was a participant at many scientific international conferences. He is an author and co-author of more than 60 scientific publications worldwide including 8 publications in the Philadelphia list. Privately, he loves skiing and music from vinyl records.',institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"481",title:"Instrumental Chemistry",slug:"instrumental-chemistry"}],chapters:[{id:"63177",title:"Introductory Chapter: Why Atomic Force Microscopy (AFM) is One of the Leading Methods of Surface Morphology Research of all Engineering Material Groups",doi:"10.5772/intechopen.80446",slug:"introductory-chapter-why-atomic-force-microscopy-afm-is-one-of-the-leading-methods-of-surface-morpho",totalDownloads:1150,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Tomasz Tański, Bogusław Ziębowicz, Paweł Jarka and Marcin\nStaszuk",downloadPdfUrl:"/chapter/pdf-download/63177",previewPdfUrl:"/chapter/pdf-preview/63177",authors:[{id:"15700",title:"Prof.",name:"Tomasz Arkadiusz",surname:"Tański",slug:"tomasz-arkadiusz-tanski",fullName:"Tomasz Arkadiusz Tański"},{id:"241789",title:"Dr.",name:"Marcin",surname:"Staszuk",slug:"marcin-staszuk",fullName:"Marcin Staszuk"},{id:"241788",title:"Dr.",name:"Boguslaw",surname:"Ziebowicz",slug:"boguslaw-ziebowicz",fullName:"Boguslaw Ziebowicz"},{id:"213174",title:"Dr.",name:"Pawel",surname:"Jarka",slug:"pawel-jarka",fullName:"Pawel Jarka"}],corrections:null},{id:"62451",title:"Characterization of Single Polymer Molecules",doi:"10.5772/intechopen.77999",slug:"characterization-of-single-polymer-molecules",totalDownloads:1015,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter offers an overview of the use of atomic force microscopy (AFM) in polymer studies. Soft AFM cantilevers with sharp tips are useful for their relatively high spatial resolution, a few nm, and force resolution, a few tens of pN. AFM imaging is used to characterize conformational properties of single polymer chains at solid-liquid interfaces. AFM force microscopy gives molecular elasticity as well as interaction forces of single polymer chains with solids. Recent technical developments have made possible the characterization of time-resolved mechanical properties of single polymer chains, including the relaxation time and internal friction. AFM force microscopy with biomolecules, supramolecules, and mechanophores reveals the forces required for, and the kinetics of, conformational transitions and chemical reactions in these molecules at the single-chain and single bond levels.",signatures:"Milad Radiom",downloadPdfUrl:"/chapter/pdf-download/62451",previewPdfUrl:"/chapter/pdf-preview/62451",authors:[null],corrections:null},{id:"61388",title:"Forensic Potential of Atomic Force Microscopy with Special Focus on Age Determination of Bloodstains",doi:"10.5772/intechopen.77204",slug:"forensic-potential-of-atomic-force-microscopy-with-special-focus-on-age-determination-of-bloodstains",totalDownloads:1046,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"An important aspect of any crime scene investigation is to detect, secure and analyze trace evidence. In forensic examinations where topographic characterization is important like in fingermark, textile and document forgery examinations, the atomic force microscopy (AFM) imaging technique can be of value. However, it is the force spectroscopy that could make AFM a versatile tool in crime investigations. Particularly, the ability to measure changes in mechanical properties of forensic trace material over time makes this technology in potential interesting for forensic examinations. The usefulness of force measurements to evaluate the elasticity of red blood cells (RBCs) in relation to the age of a bloodstain is an interesting example. With minimally invasive AFM technology, time-dependent alterations in the viscoelasticity of RBCs that occur during the aging of bloodstains can be featured. A discrimination between traces left by the perpetrator and other persons that have been present at the crime scene will thus be enabled. A recently obtained proof-of-concept demonstrating the usefulness of AFM for age estimation of bloodstains will be described. Additionally, the usefulness of AFM imaging and force spectroscopy for human hair, document forgery, textile fiber, fingermark and gunshot and explosive residue examinations will be discussed.",signatures:"Threes Smijs and Federica Galli",downloadPdfUrl:"/chapter/pdf-download/61388",previewPdfUrl:"/chapter/pdf-preview/61388",authors:[null],corrections:null},{id:"61681",title:"Scanning Probe Techniques for Characterization of Vertically Aligned Carbon Nanotubes",doi:"10.5772/intechopen.78061",slug:"scanning-probe-techniques-for-characterization-of-vertically-aligned-carbon-nanotubes",totalDownloads:939,totalCrossrefCites:6,totalDimensionsCites:9,hasAltmetrics:0,abstract:"This chapter presents the results of experimental studies of the electrical, mechanical and geometric parameters of vertically aligned carbon nanotubes (VA CNTs) using scanning probe microscopy (SPM). This chapter also presents the features and difficulties of characterization of VA CNTs in different scanning modes of the SPM. Advanced techniques for VA CNT characterization (the height, Young’s modulus, resistivity, adhesion and piezoelectric response) taking into account the features of the SPM modes are described. The proposed techniques allow to overcome the difficulties associated with the vertical orientation and high aspect ratio of nanotubes in determining the electrical and mechanical parameters of the VA CNTs by standard methods. The results can be used in the development of diagnostic methods as well as in nanoelectronics and nanosystem devices based on vertically aligned carbon nanotubes (memory elements, adhesive structures, nanoelectromechanical switches, emission structures, etc.).",signatures:"Marina V. Il’ina, Oleg I. Il’in, Vladimir A. Smirnov, Yuriy F. Blinov,\nBoris G. Konoplev and Oleg A. Ageev",downloadPdfUrl:"/chapter/pdf-download/61681",previewPdfUrl:"/chapter/pdf-preview/61681",authors:[null],corrections:null},{id:"62909",title:"Characterization of Multiblock (Segmented) Copolyurethane- Imides and Nanocomposites Based Thereof Using AFM, Nanotribology, and Nanoindentation Methods",doi:"10.5772/intechopen.78625",slug:"characterization-of-multiblock-segmented-copolyurethane-imides-and-nanocomposites-based-thereof-usin",totalDownloads:982,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"This chapter reviews our results on the morphology, tribological, and local mechanical property investigations of new copoly(urethane-imide)s (coPUIs) and nanocomposites based thereof using atomic force microscopy (AFM) and nanoindentation (NI) methods. AFM in the contact mode of lateral forces revealed the presence of different contrast phases on the surface of synthesized films which depends on the chemical structure of monomers used. Single-walled carbon nanotubes (SWCNTs), carbon nanofibers, graphene, tungsten disulfide and tungsten diselenide were introduced into coPUI matrices. Dependencies of microhardness and modulus of elasticity on the depth of indentation have been obtained. It was found that for each synthesized coPUI, there is only one type of carbon nanomaterials that exerts the greatest influence on their characteristics. The improvement of mechanical properties is found to mainly depend on the nature of the polymer matrix and filler. Our results showed that effective methods for improving of tribological characteristics can be either modification by SWCNTs (up to 1 wt.%) or heating at 30°C. Synthesized coPUI films and nanocomposites are very promising materials and can be used as thermoplastic elastomers for tribological applications, and their physical-mechanical properties can be controlled both by temperature and by mechanical action.",signatures:"Tatiana Evgenievna Sukhanova, Tatyana A. Kuznetsova, Vasilina A.\nLapitskaya, Tatiana I. Zubar, Sergei A. Chizhik, Milana E.\nVylegzhanina, Aleksandr A. Kutin, Andrey L. Didenko and Valentin\nM. Svetlichnyi",downloadPdfUrl:"/chapter/pdf-download/62909",previewPdfUrl:"/chapter/pdf-preview/62909",authors:[null],corrections:null},{id:"64959",title:"High-Magnification SEM Micrograph of Siloxanes",doi:"10.5772/intechopen.82076",slug:"high-magnification-sem-micrograph-of-siloxanes",totalDownloads:1339,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"SEM is a powerful and efficient microscopy for the analysis of nanomaterials. Although this imaging technique is common and several standard methods exist for chemical analysis, questions remain about the optimal magnification and voltage to be used. The chemical molecules are relatively sensitive to the electron beam. HMDS is as often as possible utilized for surface treatment at the covering of the photosensitive material on the wafer, and trimethylsilanol is created, together with alkali, by hydrolysis of HMDS. The best viewing condition to HMDS and reaction products of organosilicons. The greatest challenges of working with organosilicons molecules are imaging and characterizing features on such a small scale by SEM. The results support the conclusion that, contrary to what is usually recommended, it is best to determine the structure of organosilicon molecules without spectroscopy. It has been a convenient method for the emergence of the structure of HMDS and reaction products. Many micro/nanofabrication technologies have been invented and developed during the past decades. Indeed, some of them have already been widely applied in the cell biology study. In this section, we introduce and emphasize on several prominent technologies, such as soft lithography, electrospinning, nanostructured patterning technologies (including dip pen, e-beam writing, nanoimprint lithography, nanoshaving, and so on), and three-dimensional fabrications. Over the past decade, nanotechnology research has shown exciting evidence that key biological processes (e.g., osteoblast proliferation, osteoblast gene expression, and initial protein adsorption that control such events) can be easily manipulated by modifying the nanotopography of Ti implants. A table is also presented to highlight the pros and cons of different major technologies.",signatures:"Arzu Erol",downloadPdfUrl:"/chapter/pdf-download/64959",previewPdfUrl:"/chapter/pdf-preview/64959",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6172",title:"Creep",subtitle:null,isOpenForSubmission:!1,hash:"e4bebb76aea6fbaad3502b8de2a43e7c",slug:"creep",bookSignature:"Tomasz Tanski, Marek Sroka and Adam Zielinski",coverURL:"https://cdn.intechopen.com/books/images_new/6172.jpg",editedByType:"Edited by",editors:[{id:"15700",title:"Prof.",name:"Tomasz Arkadiusz",surname:"Tański",slug:"tomasz-arkadiusz-tanski",fullName:"Tomasz Arkadiusz Tański"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5474",title:"Study of Grain Boundary 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Chang and Jairo Castellar-Lopez",dateSubmitted:"June 15th 2021",dateReviewed:"July 12th 2021",datePrePublished:"September 13th 2021",datePublished:"March 16th 2022",book:{id:"10707",title:"Primary Health Care",subtitle:null,fullTitle:"Primary Health Care",slug:"primary-health-care",publishedDate:"March 16th 2022",bookSignature:"Ayşe Emel Önal",coverURL:"https://cdn.intechopen.com/books/images_new/10707.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"25840",title:"Prof.",name:"Ayse Emel",middleName:null,surname:"Onal",slug:"ayse-emel-onal",fullName:"Ayse Emel Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"342716",title:"Assistant Prof.",name:"Aileen",middleName:null,surname:"Y. Chang",fullName:"Aileen Y. Chang",slug:"aileen-y.-chang",email:"chang@email.gwu.edu",position:null,institution:null},{id:"342718",title:"Dr.",name:"Evelyn",middleName:null,surname:"Mendoza-Torres",fullName:"Evelyn Mendoza-Torres",slug:"evelyn-mendoza-torres",email:"evelyn.mendozat@unilibre.edu.co",position:null,institution:null},{id:"427633",title:"Dr.",name:"Franklin",middleName:null,surname:"Torres",fullName:"Franklin Torres",slug:"franklin-torres",email:"dummy+427633@intechopen.com",position:null,institution:null},{id:"427634",title:"Dr.",name:"Wendy",middleName:null,surname:"Rosales-Rada",fullName:"Wendy Rosales-Rada",slug:"wendy-rosales-rada",email:"dummy+427634@intechopen.com",position:null,institution:null},{id:"427635",title:"Dr.",name:"Liliana",middleName:null,surname:"Encinales",fullName:"Liliana Encinales",slug:"liliana-encinales",email:"dummy+427635@intechopen.com",position:null,institution:null},{id:"427636",title:"Dr.",name:"Lil",middleName:null,surname:"Avendaño",fullName:"Lil Avendaño",slug:"lil-avendano",email:"dummy+427636@intechopen.com",position:null,institution:null},{id:"427637",title:"Dr.",name:"María Fernanda",middleName:null,surname:"Pérez",fullName:"María Fernanda Pérez",slug:"maria-fernanda-perez",email:"dummy+427637@intechopen.com",position:null,institution:null},{id:"427638",title:"Dr.",name:"Ivana",middleName:null,surname:"Terán",fullName:"Ivana Terán",slug:"ivana-teran",email:"dummy+427638@intechopen.com",position:null,institution:null},{id:"427639",title:"Dr.",name:"David",middleName:null,surname:"Vergara",fullName:"David Vergara",slug:"david-vergara",email:"dummy+427639@intechopen.com",position:null,institution:null},{id:"427640",title:"Dr.",name:"Estefanie",middleName:null,surname:"Osorio-Llanes",fullName:"Estefanie Osorio-Llanes",slug:"estefanie-osorio-llanes",email:"dummy+427640@intechopen.com",position:null,institution:null},{id:"427641",title:"Dr.",name:"Paige",middleName:null,surname:"Fierbaugh",fullName:"Paige Fierbaugh",slug:"paige-fierbaugh",email:"dummy+427641@intechopen.com",position:null,institution:null},{id:"427642",title:"Dr.",name:"Wendy",middleName:null,surname:"Villamizar",fullName:"Wendy Villamizar",slug:"wendy-villamizar",email:"dummy+427642@intechopen.com",position:null,institution:null},{id:"457495",title:"Dr.",name:"Jairo",middleName:null,surname:"Castellar-Lopez",fullName:"Jairo Castellar-Lopez",slug:"jairo-castellar-lopez",email:"dummy+427643@intechopen.com",position:null,institution:null}]},book:{id:"10707",title:"Primary Health Care",subtitle:null,fullTitle:"Primary Health Care",slug:"primary-health-care",publishedDate:"March 16th 2022",bookSignature:"Ayşe Emel Önal",coverURL:"https://cdn.intechopen.com/books/images_new/10707.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"25840",title:"Prof.",name:"Ayse Emel",middleName:null,surname:"Onal",slug:"ayse-emel-onal",fullName:"Ayse Emel Onal"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11545",leadTitle:null,title:"Tunnel Engineering - Modelling, Construction and Monitoring Techniques",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tThe immense benefits of tunnels can be readily recognized and have led to great strides in areas such as transportation, stormwater drainage, waste disposal, and pipeline networking. Requirements for tunnels depend on the intended functions and factors such as size, depth, configuration, and underground conditions. Achieving the desired functionality is usually multifarious and complex due to the range and interrelationships of the myriad of issues that must be taken into account.
\r\n\r\n\tThis book provides further insights into the design and construction processes as well as the performance of tunnels. Areas covered include design considerations, modeling approaches, drilling and excavation techniques, measurement and instrumentation, tunneling in offshore environments, machinery and equipment, ground investigations, cost-benefit evaluations, environmental and social impacts, sustainability, and health and safety. The book aims to provide supplementary information that advances the frontier in tunnel engineering whilst serving as a first recourse for those new in the field of tunneling.
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Hitherto, he was an assistant professor at Prince Mohammad Bin Fahd University, a research fellow at the University of Leeds, a lecturer at the University of Uyo, and a senior consultant at Sustainable Energy Environmental and Educational Development (SEEED), USA. He holds a doctorate in Civil Engineering. His interests include numerical/analytical methods for engineering problems; experimental and numerical modeling of geotechnical systems; site investigation, and laboratory and field geotechnical experimentation; computational fluid dynamics; stochastic and optimization analysis; and structural analysis and design.",institutionString:"University of Wolverhampton",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Wolverhampton",institutionURL:null,country:{name:"United Kingdom"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"466997",firstName:"Patricia",lastName:"Kerep",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/466997/images/21565_n.jpg",email:"patricia@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"16895",title:"Telestroke for the Long-term Management of Risk Factors in Stroke Survivors",doi:"10.5772/24226",slug:"telestroke-for-the-long-term-management-of-risk-factors-in-stroke-survivors",body:'Stroke is a major public health issue worldwide and, being the largest cause of chronic disability in adults, places a significant burden on health care systems. According to the World Health Organisation (WHO), around 15 million people each year suffer a stroke, and 5 million are left with a permanent disability. Over the past two decades, stroke has become an increasingly treatable disease with the development of evidence-based treatments such as tissue plasminogen activator (rt-PA) for the treatment of acute ischemic stroke and admission of patients to stroke units. This has led to a decrease in stroke mortality in developed countries and an increase in the number of survivors with impairment or disability. Stroke is an example of a largely preventable disease that presents acutely, with a short time window within which damage to the brain can be reduced. There is a high risk for residual disability which impacts significantly on society, the patients and their families. Stroke recurrence can lead to a progressive decline into dependency, subsequently placing a significant financial burden on society. In 2008, the indirect and direct costs of stroke in the United States were calculated at $65.5 billion.
87% of strokes are caused by cerebral infarction and are therefore amenable to a number of pre-stroke preventive strategies as well as thrombolytic therapy or intravascular clot retrieval strategies in the acute phase. The second major subtype of stroke, i.e. intracerebral parenchymal haemorrhage, is largely preventable through pre-stroke blood pressure control.
In this chapter, we will primarily discuss the current data regarding prevention and limitation of acute brain damage resulting from cerebral infarction, but will also consider other expanding areas in stroke care where telemedicine has a potential role. We will therefore examine the use of telestroke in stroke survivors after discharge from hospital, with particular emphasis on developed models of care and their applicability.
In stroke survivors, the overall risk of recurrent stroke (fatal or nonfatal) is high (approximately 20%) at 5 years. A recent study carried out in Perth, Australia, which aimed to determine the absolute frequency of first recurrent stroke and disability, as well as the relative frequency of recurrent stroke, demonstrated that over a 10-year follow-up period, the risk of first recurrent stroke is 6 times higher than the risk of first-ever stroke in the general population of the same age and sex. In addition, almost one half of survivors remain disabled, and one seventh require institutional care. The burden of stroke will continue to be a significant healthcare problem unless the incidence of not only first-ever, but also recurrent stroke and its disabling sequelae are reduced.
In 1970, a landmark paper showed that hypertension was a major risk factor for all types of stroke. It has since been confirmed in more recent studies that high blood pressure is indeed a powerful determinant of risk for both ischaemic stroke and intracranial haemorrhage.
Other major risk factors for stroke such as obesity, smoking, embolic heart disease and diabetes mellitus are well recognised
The potential for recurrent stroke can be substantially reduced by effective management of these risk factors, and the development of systems that can enhance the prevention of stroke recurrence is an important priority and challenge in both the developed and developing worlds. The same few major risk factors account for many of the leading chronic health problems worldwide. Nevertheless they remain on the increase and are poorly managed in the majority of affected individuals. According to the WHO, the number of overweight people worldwide will increase to 2.3 billion by 2015, and more than 700 million will be obese. In parallel, more than 200 million people have diabetes and the WHO projects that the prevalence will double between 2005 and 2030.
The main challenge involves reducing the prevalence of recurrent stroke, particularly in remote and rural areas, through: i) effective strategies for the management of risk factors; and ii) educating the target population (essentially stroke victims and carers/family members) to increase awareness of risk factors and preventive strategies.
Prevention is the most effective way of reducing the burden of recurrent stroke on society. Although it has been shown that effective long-term risk factor management can reduce the risk of recurrent stroke by around 70-80% through the implementation of simple best practice recommendations, secondary prevention measures remain frequently sub-optimally implemented in stroke survivors. Indeed, in an editorial in the journal
All this would argue that secondary prevention and long-term management of risk factors is a neglected area that requires urgent attention and has clearly defied efforts, even in the developed world, for optimal implementation.
Globally, the majority of strokes occur in rural areas where there is often a lack of stroke services. In these areas, stroke care is often fragmented and does not adhere to recommended guidelines. This, together with the geographical barriers that are associated with a general attenuation of access to healthcare resources and the paucity of stroke experts frequently leads to an inequitable distribution of resources and limited access to preventive strategies and evidence–based care. On a global scale it would seem that not only are vascular risk factors on the increase, but they are also not systematically recognised or diagnosed. The results of a recent longitudinal cohort study in the United States, for example, revealed high rates of undiagnosed hypertension and diabetes among stroke survivors.
The problem is further compounded by the lack of public awareness and knowledge of stroke risk factors and preventive strategies. A recent study of stroke survivors found that only 60.5 percent were able to identify one stroke risk factor and only 55.3% were able to identify one stroke warning sign. Similarly, a study of 286 consecutive patients who were attending a stroke outpatient clinic in Switzerland for the first time 3 months after being discharged from hospital for a first stroke, reported that despite an improvement in hospital treatment, cerebrovascular risk factor control was not optimal. This may have been partly related to the patients’ awareness and knowledge. Older patients and patients with excellent recovery were at particular risk of recurrent stroke due to poor awareness of vascular risk factor control. Better strategies are clearly needed to help stroke survivors recognise and play a part in the control of vascular risk factors so as to improve the prevention rate of recurrent stroke.
Telemedicine has been defined, simply, as the delivery of healthcare services to the underserved, employing telecommunication. A more extensive definition is “the process by which electronic, visual and audio communications are used to provide diagnostic and consultation support to practitioners at distant sites, assist in or directly deliver medical care to patients at distant sites, and enhance the skills and knowledge of distant medical care providers. Telemedicine, as a distance communication tool, was first attempted in radiology 50 years ago and subsequently in psychiatry. Since 1999 there has been a gradual increase in the number of telemedicine programmes and more recently a growing interest in its use in stroke, mainly in facilitating thrombolysis, but also in establishing diagnoses and guiding treatment options.
“Telestroke” refers to the application of telemedicine to stroke care. This is a new application of existing technology in the care of stroke patients. Evidence suggests that telestroke is beneficial where immediate access to regular stroke expertise is not available. Thus it may help to provide stroke care to patients in remote regions and smaller urban hospitals without stroke expertise and to extend clinical research into a broader global community, thereby furthering the goal of establishing universal access to care at all levels, regardless of geographical location or hospital facilities.
Although telemedicine has until now mainly focused on the area of thrombolysis in the acute stage, it has the potential to address the remaining stages of the stroke victim’s journey following discharge from hospital or in the rehabilitation setting. Attention at all these levels can substantially lower the net cost of recurrent stroke to society through reduction of lost productivity, nursing home costs and rehabilitation.
Demonstration projects have proven the feasibility of telestroke and suggested its potential to facilitate access to specialist stroke expertise in hospitals without access to specialist clinicians. In particular, the use of this technology may promote implementation of best practice management of vascular risk factors in stroke survivors after discharge. One of the main drivers has been technological advancement, such as the digitisation and compression of data permitting the rapid transfer of images. This can now be linked to systems of care that integrate person-to-person contact (which have already been developed in the areas of psychiatry and social work), thus providing a structure which delivers care to underserved areas by combining state-of-the-art technology providing the face-to-face contact that patients still need.
In 2009 we reviewed evidence of telestroke support in stroke survivors discharged from hospital. The Canadian Agency for Drugs and Technologies in Health (CADTH) reported on a systematic review of 5 bibliographic databases examining telestroke from 1966 to December 2006. 863 citations were identified, and from these, 35 potentially relevant reports yielding 22 studies originating from the US, Germany, Canada, China, the Netherlands, Italy and Finland. Using this as a base, we further searched the literature which involved searching the relevant primary and secondary databases for all papers (peer-reviewed where possible) that covered stroke and telemedicine in stroke survivors. We combined MeSH searching with (relevant) ‘words anywhere’ searching. The results were examined via abstracts; if no abstracts were available, full text-versions were sighted. Selected papers were obtained in full-text version and additional relevant papers were searched and reviewed as needed from references cited in papers. The searches were limited to the period from 1998 to 2009 and no restriction was placed on study designs. Primary databases searched were Medline EMBASE, CINAHL, AMED and PsycInfo. We also searched the Cochrane databases. The main subject terms used were telemedicine, telephone, electronic mail, videoconferencing and stroke. Additional subject terms searched were patient discharge and hospitals, and other relevant terms searched were telestroke, telehealth, primary-secondary and post-acute, patient surveillance, patient monitoring, and risk assessment. From the primary sources we found 82 papers in total of which 72 were retained for examination. From Cochrane, one systematic review was found. The final studies included can be seen in Table 1. In 8 studies the telemedicine focus was not on rehabilitation; of these six were RCTs. Telerehabilitation was the focus of 12 other studies, only one being an RCT. A total of 28 studies evaluated a variety of measures in stroke patients.
RCT | Mayo NE, et al, 2008 | Telephone calls by nursing care coordinator over 6 weeks after discharge. | 190 stroke patients n=96 intervention n=94 controls | Nurse Care Manager, Patient’s Local Physician |
RCT | Joubert 2008 | Integrated model of care (ICARUSS) Risk factor management | 91 stroke survivors and 95 controls | Care-Coordinator and Patient’s General Practitioner |
RCT | Joubert 2008 | Integrated model of care (ICARUSS) Screening for depression (PHQ9) | 91 stroke survivors and 95 controls | Care-Coordinator and Patient’s General Practitioner |
RCT | Grant JS et al, 2002 | Telephone contact strategy for problem- solving therapy over 18 months. | 74 Stroke Survivors and Caregivers in three groups: treatment, sham and control | Research Nurse |
RCT | Boter H, 2004 | Outreach care included 3 telephone calls and a home visit within 5 months of discharge. | Randomized 536 stroke patients; 263 (with 211 carers to standard care plus outreach care and 273 (with 230 carers) to standard care only. | 13 Stroke nurses |
Qualitative study | Pierce 2004 | Internet based education and support | 9 Caregivers of patients with stroke using Caring~Web | Nurse |
Descriptive Study | Buckley KM, Tran BQ, Prandoni CM, 2004 | Tele-health nurses use videophones to contact caregivers | 21 family caregivers of stroke patients | Nurse Investigator |
Non-Rehabilitation Studies using Telestroke in Stroke Survivors
Of the non-rehabilitation telestroke studies involving stroke survivors, one was an Internet educational model, there was one passive case management model, one was a videophone-supported educational model, one was a nursing outreach telephone support model, one was an interactive telephone support model and one was a telephone/ Internet-based EDC integrated care model. Three involved caregivers only, one involved patients and general practitioners, one involved patients and caregivers, and one involved stroke specialists, patients, caregivers and primary care physicians. There were 21 studies (one being an RCT) describing the application of telestroke in rehabilitation. Most of the studies have described the use of technology solutions, principally to support rehabilitation activities.
The HESTIA Study Group instituted a programme of outreach care consisting of 3 telephone calls and one home visit by nursing staff within the 5 months after discharge. The target population was patients and carers, and the intervention was general support, education and advice. General practitioners were indirectly involved, in that nurses advised contact with the general practitioner where appropriate. Quality of life according to the Short Form 36 (SF 36) and dissatisfaction with care were assessed at 6 months. Apart from improved scores on the SF-36 domain ‘Role Emotional’ no difference was found between patients receiving outreach nursing stroke care and controls.
In the study by Pierce at al. an Internet-based education and support intervention was directed at rural caregivers. Outcomes in this qualitative study were satisfaction with the intervention and an exploration of caregivers’ experience. Of the nine caregivers studied, all indicated satisfaction with the “Caring-Web” and eight agreed or strongly agreed that the tool was needed.
An RCT evaluating the effect of telephone intervention with family caregivers of stroke survivors, involving a social problem-solving therapy over a period of 18 months, yielded significantly positive results on a variety of measures such as problem-solving skills, social functioning, caregiver depression, measures of vitality, role limitations related to emotional issues and caregiver preparedness. The target population was caregivers, and intervention was weekly or bi-weekly telephone calls. The three groups were tested-intervention, sham and control.
In a descriptive study, targeting family caregivers of stroke patients, Buckley et al. used videophones to provide education and support and to assess patients and monitor progress. They studied the factors that influenced receptiveness for the use of this tool. The telehealth calls were made weekly and the duration of the intervention was 5 weeks.
Mayo et al. evaluated the effect of passive case management over a period of 6 weeks after discharge of stroke patients from hospital. The telestroke intervention was telephone contact and involved surveillance, information exchange, medication management, health system guidance, active listening, family support, teaching and risk identification. The target populations in this RCT was the stroke patients and their general practitioners. There was no difference between patients exposed to usual post-discharge management and this intervention regarding health-related quality of life, reduction of health services utilisation or stroke impact.
Moulin et al. have reported on the emergency neurology network in Franche-Comté (RUN-FC), which monitors stroke victims over a five-year period following discharge. A nurse from the network maintains regular contact with the patients and organizes a consultation with a neurologist if a problem is detected. The patient\'s GP is also kept informed at all times. Since 2003, 2,600 stroke victims have been followed up within the network and 20% have required action to be taken by the network at least once. The survival rate of discharged patients at 18 months has risen from 87% between 1987 and 1994, to 94% between 2003 and 2006. For patients in the network, the stroke recurrence rate at 18 months has also increased from 4.8% between 1998 and 2002, to 2.6% between 2003 and 2007. RUN-FC illustrates the usefulness of telemedicine for stroke survivors and the need to develop it further throughout France. Furthermore, in the long-term, the network has significantly reduced the stroke mortality rate and the number of recurrences, and has considerably improved the quality of life of patients in the network.
Joubert et al. examined the effect of a telemedicine intervention on both vascular risk factor management and depressive symptoms in the ICARUSS study. In this RCT, the intervention was telephone contact with patients and carers, and bi-directional information sharing between coordinator, patient and general practitioner using telephone and facsimile, coupled with data management, surveillance and response through a web-based EDC. Telephone contact between stroke specialist and primary care physician was maintained by telephone. The target populations were patients, carers and general practitioners. In this study, the pilot results were supportive of this simple telestroke model in that there was a significant improvement in a variety of outcome measures, such as optimal management of risk factors, BMI, physical activity, and disability as measured by modified Rankin score (mRS) in patients exposed to the telestroke intervention compared to usual care. Moreover, depressive symptoms were significantly reduced in the telestroke group. The protocols for the ICARUSS model are diagrammatically depicted in figures 1 and 2. The initial results from the pilot study have resulted in the multicentre Australian Study using the adapted ICARUSS model of care in urban stroke patients. As a result of the experience accrued from the ICARUSS study, important role players in an effective telestroke model have been identified. Moreover, the implementation of telestroke at various stages of the stroke survivor’s journey has been clarified.
About 80% of stroke survivors are reliant on family caregivers for emotional and physical support, ranging from assisting with activities of daily living to arranging and escorting to medical appointments. Caregivers are often elderly, and often frequently infirm themselves. Caregiver failure or collapse is more frequently a cause for stroke survivor institutionalisation than is commonly realised. If the carer can be ‘enrolled’ and supported as a member of the team, there is an increased likelihood that the stroke survivor will remain in the community.
The Internet-based support study by Pierce et al. highlights the need of caregivers for emotional and social support and the general acceptance of a telestroke support system. Pilot work had indicated that a major issue identified by caregivers was the low level of knowledge about stroke in general, which their Internet-based study attempted to rectify. Important issues of acceptance by caregivers was emphasised in the study of Buckley et al. who found that for some carers, a technological challenge constituted only an extra burden. Some caregivers only wanted simple telephone support. In this study, it was evident that the nurse’s support was paramount.
Assessment of caregivers’ needs and limitations is important. Their level of technical competence, fear of intrusion into their privacy and desire for inclusion into a telestroke system all need to be evaluated.
Diagrammatic representation of telestroke process (ICARUSS protocol)
Three-monthly Telestroke cycle of communication between coordinator, patient, caregiver and general primary care physician illustrating pre- and post general practice telecommunication (ICARUSS protocol)
Often overlooked issues include the functional ability of the caregiver, the amount of time able to be provided by the caregiver, the number of individuals sharing the burden, and involvement of the caregiver in management planning prior to discharge. The need for a flexible approach to telephone contact with caregivers has been emphasised in several studies. These studies stress that there is an unmet need in caregivers, and that although the solution is probably not simple, further research is required in this area.
The multicentre RCT in the Netherlands did not show evidence of either improving quality of life or lessening dissatisfaction with care. However, the study was of short duration with a low level of intervention, and a deliberately passive, but supportive and advisory role. Thirteen stroke nurses were employed for intervention in 263 stroke survivors. The Australian study, ICARUSS, differed in that one nurse coordinator supported over 90 patients for a period of one year. Similar to the Dutch study, a negative result was obtained in the study by Mayo et al. where the intervention was deliberately passive case management. In the study by Grant et al., the problem-solving partnership resulted in significant improvement over many domains, as in the ICARUSS study.
There is now evidence from the ICARUSS study that an integrated telestroke model can result in significantly improved risk factor management, as well as decreased levels of post-stroke depressive symptoms. Despite the published importance of implementing best practice management principles, this is the only telestroke study that has addressed risk factor management directly and shown results in an RCT.
There are different roles to consider for primary care physicians and specialists in stroke services. In the study by Boter et al., patients and carers were advised to seek help from primary care physicians when necessary. The contact and coordination with primary care physicians was more direct and active in the study by Mayo et al. Neither supported the general practitioner in risk factor management. In the Australian ICARUSS model, there is bi-directional information sharing regarding risk factor status of stroke survivors between the coordinator, specialist stroke services and primary care physician. Determined reaction to persistently abnormal values is an integral part of the model. The telephone support from the specialist physician to the primary care physician is part of the “shared care” component. In ICARUSS, screening for symptoms of depression is performed on a three-monthly basis and the results are faxed to the primary care physician. ICARUSS is an example of a telestroke model that maintains specialist involvement in the long-term. The immediate, real-time specialist support to the primary care physician provides the “contemporaneous sharing of responsibility” between primary care physicians and specialists, which is the element of shared care.
The coordinator plays a key role in all the telestroke models for stroke survivors described above. In some, the role is passive, while in others the interaction is more active. The coordinator plays a part in problem-solving, education, surveillance and reaction, as well as psychological and social support. In the ICARUSS model, the coordinator provides the link between patient, caregiver, primary care physician and specialist stroke services.
To date, the limited availability and acceptance of past Information and Communication Technology ( ICT) possibilities has limited the possible support options. At this stage, it is now possible to explore what Telestroke Support Management Services are available and appropriate as an adjunct to human contact, and in combination with some of the current telemedicine services outlined in Table 2. Any new technology should viewed as an advance on existing systems and compared rigorously in terms of cost-effectiveness as well as efficacy.
Across the different studies, a range of technology options have been used including telephone, facsimile, email, videoconferencing, and internet-based communication, which may be generic or personalized. Simple telephone contact has been shown to be useful in different situations, such as giving practical problem-solving advice to caregivers. Moreover, the contact has been useful in reducing stress. Telephone interviews have been shown to be reliable in the application of a variety of assessment and measuring tools, such as the Stroke Impact Scale (SIS) and proven reliable for the evaluation of disability and cognitive function in community outpatients. Telephone administration of the Patient Health Questionnaire (PHQ9) has also been validated in stroke patients. This instrument has demonstrated reliability as a screening tool for Post Stroke Depression. There is a need to determine the best modality to achieve the requisite goal in stroke survivors. These goals may be risk factor modification, patient and carer education, detection and management of post-stroke depression, carer support, strategy implementation, rehabilitation or simple surveillance of health service usage. Different modalities may be appropriate for different goals; simple telephone calls may suffice for patient and carer education or support, whereas a tele-rehabilitation programme may require videoconferencing, as would a psychiatric intervention for depression.
TELESTROKE SERVICES | |||||
Care Coordination and Secondary Stroke Prevention | Other Telemedicine Functions | Tele-Rehabilitation | |||
Carer Support and Problem-Solving | Risk Factor Management | Emergency Response | Health Information and Education | Medication Compliance | Remote assessment and therapy |
Overview of Telestroke potential
It is unlikely and undesirable that single solutions for different scenarios can be developed to meet the above telestroke service needs. Functional requirements need to be analysed and all available options considered. Although the literature reveals an interest in experimenting with new ICT from video conferencing and Internet web-cams, to virtual reality haptic workbenches, most ICT studies have relied on the telephone to study post-acute stroke survivor needs. Many of the ongoing assessment tools could potentially be integrated into handheld devices where audio and visual evidence could be directly captured.
Some studies have indicated that technology choices are limited to those acceptable to the survivors and/or their carers. Perhaps more important is the fact that the spectrum of ICT options is expanding rapidly, while costs are decreasing. However, deployment of these options is not uniformly available across all geographical and demographic users. For example, fibre optic cable is not yet as ubiquitous as copper networks and 3G intelligent mobile phone networks do not have the same coverage as GSM.
A missing systems requirement in the design of telestroke services is the functional requirement for implementation of the care coordinator role. Solutions adopted will depend on a number of factors such as the capture area of the services, remoteness of care and health provider locations, and the number of survivors involved - in other words, the caseload. It is expected that caseloads of over 80 stroke survivors would need a full time care coordinator, and their productivity would depend on the support systems available. The coordinator requirements are outlined in Table 3.
CC to CR/ICG Operational Issues | ||||
Telephone contact | Inexpensive | Reliance on Phone contacting limits case load for CC. Ubiquitous and Saves Travel Validated for several assessments. | Generally effective Gives personal contact. Non-threatening to elderly | Note-taking of interactions |
Facsimile | Inexpensive | Ubiquitous | Generally effective. Specified usage | Storage needed |
Video-conferencing for visual contact | As for ICG; saves travel. Initial Setup can be costly and is time-consuming if used frequently. | Not readily available at home. Skype and webcam is possible. | Can be useful for case referral conferences | Effort required to arrange; visit may be more effective |
Internet Contact | Medium to high costs to setup computer, modem and broadband services | Most efficient use of CC time for data collection, but not effective for human interaction. Elderly may have usage barrier | Can be useful for sharing electronic records and reports | Privacy and data security obligations |
Web Page | Costly to set up and resources needed to maintain content | Provides a 24/7 resource to ICG/CR on more frequent types of info needs. Elderly may have usage barrier | Enables links to service provider organisations of relevance to users | Needs updating regularly to be relevant; users may need a secure log-on |
Health Records 1 | Initial filling-in on paper is fast and low cost if well designed | An effective system is required that meets medical authority standards. | Need to be able to share with appropriate third parties | Security and privacy requirements; long-term storage |
Contact Database 2 | Software is available for this function; desirable to integrate with EDS | Essential for efficient interactions | Essential for efficient interactions | Needs to portable |
Electronic Documents System 3 | Can be expensive and needs tailoring for CC needs | Effective for data searching, studies and archiving. | Assists efficient support for hospitals, GPs and specialists | Secure archiving of data is essential |
Technology Options for Care Coordinator (CC). CC: Care Coordinator; CR: Care Receiver / Stroke Survivor; ICG: Informal Care Giver; GP: General Practitioner (of CR); ED: Emergency Department. 1 These may be proformas or other reports handled in paper form. 2 For tracking client interactions – planned and completed. 3 For managing all documents electronically – paper is scanned
Telestroke programmes should address the post-discharge management of stroke survivors and the needs of caregivers. They should facilitate risk factor and other areas of medical management by the primary care physician (traditional general practitioner or clinic-based physician). Telestroke should also counteract the effects of isolation and limited access to specialist services in rural areas.
Ideally, in a comprehensive telemedicine model a variety of items related to medical management, process, quality control and outcomes should be measured. These are shown in the Box. Of particular importance is the monitoring of vascular risk factors for the reduction of recurrent vascular events, primarily stroke – e.g. blood pressure, cholesterol, anticoagulation and blood sugar. Compliance with medication and surveillance of laboratory tests can be readily coordinated in a telestroke model.
The literature has suggested that there are a range of telestroke services that should now be considered to meet the wider needs of post-acute stroke survivors and the integrated care requirements:
Telestroke model should facilitate knowledge transfer, particularly in relation to education and best practice recommendations for risk factor management.
The system should provide, support and monitor clear management plans for secondary stroke prevention.
There should be regular survey methods applicable to telemedicine of patient, carer and health provider satisfaction.
The model should facilitate the provision, as needed, for expert consultation related particularly to stroke prevention, but also home rehabilitation and addressing patient and carer problems.
Telestroke should reduce the need for travel, particularly in remote areas.
Ideally, a telestroke model should provide ongoing, updated guidelines for risk factor management to primary physicians in an accessible, user-friendly way.
The system should be able to scientifically evaluate outcomes and cost, and to address the questions of effectiveness and economic implications.
The system should be capable of ‘flagging’ patients at increased risk. This should be part of the bi-directional information feedback loop.
Telestroke should allow for evaluation of health-related quality of life (HRQL).
There should be a standardised manner of reporting stroke outcome measures, risk outcome measures and resource utilisation across multiple telestroke systems to allow for comparison.
The telestroke system should facilitate what is essentially case-management of stroke survivors in a bi- or multidirectional way (health provider to client and client to health provider).
In stroke survivors, the most appropriate and acceptable support for patients and their carers and families should take into account to the fact that most stroke patients are elderly, as are their carers, and the majority are not technologically proficient. This means that the model of telecommunication should be adaptable and appropriate to the needs of patients to ensure compliance and usage both in the short- and the long-term. It should be remembered that three role players need to be supported after discharge - i.e. patient, carer and primary care physician. Patients and care givers need psychological support, practical advice in addressing what is often a combination of risk factor management and adaptation to physical disability and social change. The primary care physician needs support and guidance in implementing the best practice guidelines for risk factors management and the treatment of post-stroke depression. An integrated care model should enhance the quality of care for stroke survivors by linking together domains such as education, surveillance, and detection of abnormalities. Such a telestroke model should contain discrete elements of intervention, so that depending on the social and economic setting, the appropriate intervention elements of the model can be selected.
Risk factors Social support Mental health of patients Quality of Life Economic measures (utilization of services) Measurement of neurological impairment Measurement of disability and functioning Medication compliance Laboratory tests Recurrent stroke, vascular event or death Knowledge transfer |
A range of current telemedicine applications is potentially available for telestroke use. Many studies have shown the effectiveness of telemedicine for care management in a variety of chronic diseases such as for general health status monitoring (self-reported, or with home-based devices) with scheduled interventions such as nurse visit or GP consultation (video, telephone or physical attendance) ; medication compliance and modification, depending on symptoms and side-affects; and the early detection of deterioration of patients leading to ‘just-in-time’ interventions, preventing unnecessary admissions and healthcare costs. These are summarised in Table 3.
Telemedicine studies have shown various drawbacks which need to be considered. Many telehealth projects are neither successfully implemented, nor accepted despite being medically appropriate and technically viable. Cho et al. recently analysed the theoretical framework underpinning the implementation of a telestroke service (REACH) and a Swedish teleradiology service as models of care. Barriers to implementation were identified as insufficient planning of IT infrastructure, lack of long-term vision for sustainability, lack of contextual perspective, and poor communication with a lack of early involvement of important role players. Financial barriers contributing to difficulties with the diffusion of the project, if not foreseen and accounted for from early on, can lead to limited or aborted important implementation issues. Existing work practices have to be acknowledged, as IT innovations do not occur
Organisational structures and various public and insurance funding changes may be needed to accommodate a different care regime that includes outreach through telemedicine. The sharing of patient health records between public and private health providers, medical and care professionals, and hospital and community centre care coordinators, leads to security, privacy and liability issues that need solving. More efficient use of communication dialogue and methods are needed to efficiently manage each patient interaction – especially as coordinator and medical case loads increase with greater use of telemedicine links to patients and carers. For example, there may need to be a differentiation between problem-solving, education and motivational dialogue from structured rehabilitation management tasks. In addition, an improved human/technology interface functionality is needed to take into account individual patient disabilities, time limitations and the technical skills of the carer. A flexibility of technology solutions should be adopted that allows for rates of obsolescence, local availability of supply, and support of hardware and software, especially as such telemedicine options are extended to different regions, states and countries. The current pilot studies of home-telemedicine do not provide sufficient evidence for full deployment scaling using major public health funding, although some have produced projected business cases and others are studying world wide practices. Telehealth models vary in systems architecture from two-way to three or more ways, with various implied control modes – nursing care coordinator or clinician (agency, hospital or clinic) or community. This impacts on the cost-effectiveness of bandwidth and computing intensive solutions, even though the component costs appear to be falling. This complexity makes the difficulty of technology selection all the greater.
Although a specific search strategy for this aspect was not undertaken in this review, we noted that the resource implications of telestroke had been raised as an issue in several studies. To date, most studies have been designed to provide evidence for the technical feasibility of using current (telephone, videoconferencing) or new (Internet, Virtual Environment) technologies. Many of these studies are project-funded to address efficacy issues and full economic costs have not published. The economic impact of these telestroke systems is a critical area in need of more research. Costs involved in telestroke may include both set-up and operating costs, which have seldom been quantified. Moreover, many reported cost studies are based on such diverse technical, organisational and cost contexts that it would be difficult to draw conclusions in order to undertake a comprehensive cost-effectiveness study. It has been noted that a lack of reimbursement for clinicians may be a major impediment to the use of telestroke. Such economic issues require further investigation.
The CADTH review was inconclusive as to whether telestroke was cost-effective and safe compared to face-to-face care. The authors highlighted the lack of standardised reporting that precluded comparisons between studies and best practice determination. This would also have implications for undertaking economic evaluation studies. Thus, the evidence related to costs and cost-effectiveness of telestroke appears limited. More recently, Ehlers et al reported that at one year, the net cost per patient treated with thrombolysis using telestroke compared to standard practice was $50,000 and that at 2 years the intervention would save costs by reducing care and rehabilitation costs. However, the authors noted that although there may be potentially large savings associated with thrombolysis with alteplase delivered by telemedicine, the long-term calculations were uncertain. In another study designed to assess the cost-effectiveness of pharmacists giving advice via telephone to patients receiving a new medicine for a chronic condition (including stroke), the intervention was less costly and more effective than standard practice.
In 2010, Nelson et al. analysed the trade-off between short-term costs and long-term outcomes of telestroke in the Western States Stroke Consortium (WSSC). They studied a systematic method of comparing 2 or more interventions by measuring their costs and consequences (health outcomes) where the consequences of each are measured in common units related to the clinical objective of the interventions (e.g., life-years gained or quality-adjusted life-years). They show that telestroke was still cost-effective compared to usual care in the lifetime horizon model but not in the 90-day horizon model. However, there were certain limitations to the study. Their model did not consider stroke mimics, for example, which may also be the object of telestroke intervention. There are potential cost savings of not transferring such patients to tertiary care centres. Two new Canadian programmes have also been designed to address the economic and resource implications for telestroke, which may contribute further evidence to the debate on cost-effectiveness. Clearly, studies with long-term follow-up and consistent methodology are needed in this area.
Hersh et al. found that there were only a small number of well-designed telestroke studies in general, particularly in rural settings. There is a need for well-designed RCTs and longitudinal observational studies of clinical outcomes to demonstrate the effective use of telemedicine in stroke survivors discharged from hospital. Rigorously designed studies, such as those that have been recommended for telestroke in the acute phase, are needed.
Future trends and recommendations
There is clearly an urgent need, particularly in rural and underserved areas, to develop long-term management systems in stroke survivors that are both integrated and sustainable, serving all sections of the population, and with particular emphasis on the sustained implementation of best practice risk factor management. In these more remote areas of the world, the implementation of telemedicine may fill the gap in health care provision created by the high demand on healthcare provider time, the critical shortage of professional health services and geographical distance thereby progressing the ideals of the WHO contained in the Helsingborg Declaration.
Ultimately, the long-term management of risk factors in stroke survivors rests with the primary care physician or other health practitioner acting as the final ‘locus of control’ for the patient. Unfortunately, despite the enormous calculated benefits flowing from the effective implementation of best practice recommendations, therapeutic inertia is common at primary care level. To address this, a combination of ‘hub and spoke’ case-management model (care coordinator, with multiple stroke survivors) and linear model (specialist, coordinator, carer, patient and primary care physician) could be advantageous. Telestroke may also minimise the inappropriate variations in medical practice. ICARUSS provides one telestroke model that is adaptable to various scenarios and integrates the roles of coordinator, primary care physician, specialist services and other telestroke support services in the care of both stroke survivor and caregiver. The model supports the implementation of secondary stroke prevention strategies and the detection of post-stroke depression. The focus is on providing care, support and specialist guidance to rural, remote or underserved areas in all fields related to the care of stroke survivors, in a model that continues to provide patients and carers with the face-to-face experience, but that also fully exploits the available modern technology options.
The RUN-FC network has been supported and funded by the French Health Ministry.
The ICARUSS study is supporte Ad by funding from the HCF HEALTH AND MEDICAL RESEARCH FOUNDATION. We would like to thank Melanie Cole for her editing assistance.
Regenerative agriculture is a farming and land management concept based on several principles and techniques that strengthen and restore ecosystem functions and health. Long-term usage of regenerative agriculture has shown many benefits in terms of quality and profitability for farmers, as well as improving the environment and contributing to the maintenance of a healthy agricultural landscape. Given that it is not always very clear how each action contributes to better agricultural management and drought mitigation, this chapter aims to recall the key elements that farmers must consider in regenerative agriculture in order to have the best results. It should be noted that there is more than one approach that may differ depending on local circumstances, however, the elements described in this chapter serve as a starting point for practitioners and academics who wish to learn more or deepen one of the related domains.
The existence of life is largely dependent on the richness and health of soils, which is why soil structure, together with water availability are the most valuable resources for humanity. The annual degradation of the agricultural lands puts even more pressure on farmers, forcing them to use more chemical inputs and these practices may eventually lead to extreme phenomena such as drought, floods, and eventually soil abandonment [1]. However, both farmers and policymakers continue to be neglecting the need for soil health preservation and they do not take firm restoration measures even when the situation becomes concerning.
Water, minerals, and organic matter combine to make the soil in a natural process. Soil minerals are produced in the process of natural erosion, while the organic matter is formed by the decomposition of plants and other organisms that have died. Many scientists consider soiling a finite resource that cannot be renewed during a human lifespan. We propose, in the present chapter, several techniques used and validated for faster restoration of soil properties, which may help recovery in very shorter time periods, depending on the degree of soil impairment.
Degraded soil is described as a change in the physical, chemical, and biological characteristics that results in a reduced capacity to support plant growth. The most common phenomena that usually occur are related to the fact that soil loses the capacity to deliver nutrients and water, while toxic compounds restrict plant growth, topsoil lacks of organic matter content, subsoil resources are insufficient to support plant roots, the compaction rate is substantially increased, drainage occurs with difficulty, and many of the needed microorganisms are absent.
In most common cases, the quality of the soil decreases as a result of the anthropogenic intervention, while some natural causes are aggravating the circumstances, often leading to erosion. Human activity is the most frequent cause of agricultural soil degradation and for accelerating natural soil erosion. Agriculture has deteriorated the Earth\'s soils during the last 100 years, with disastrous consequences, David R. Montgomery [2] estimates that humanity is losing 0.3% of our global food production each year due to soil erosion and degradation. Soil degradation and loss has been a problem since the beginning of agriculture and played a major role in the demise of past civilization including Mesopotamia, Antic Greece, and the Rome Empire. The element that contributes probably the most to the negative damage to the soil, more important even than deforestation is the plowing activity. Stanford University in a study from 2015 estimated the degradation rate of topsoil worldwide at a rate of 70%, with margins between 54% in Africa and 74% in North America [3]. At this time, there is no allotted restoration period, since we are eroding soil 20 times faster than we are regenerating it.
Degraded soils have a poor health state, reducing the ecosystem\'s ability to provide water and nutrients to plants, and affecting the soil nutrient web. Degraded soils have a weak structure attributable to a lack of soil biodiversity, which causes flooding, erosion, and low production. Water cannot penetrate inferior soil structures, so the rains follow the flow of gravity, transporting major amounts of minerals and salts to the groundwater, rivers, or lakes. During a drought period, there will be no moisture, and groundwater will not be replenished easily. Plants will be stressed, and yields will decrease very fast. In the tropics especially on fertile land, soil deterioration is prevalent. Natural erosion caused by wind, sun, severe rainfall, and poor human management are the most common causes.
It is critical to understand that poor agricultural management before and during a drought has a synergetic effect on soil properties. Land degradation in arid, semiarid, and sub-humid areas may be generated by various external factors including climate change, and draught may lead to desertification. Desertification may be irreversible if not intervened in time, especially when the environment becomes too dry and the soil becomes further degraded through erosion and compaction.
One of the most important hazardous environmental events in recent history was the American Dust Bowl during the years 1930–1936, when large dust storms swept topsoil from significant land areas, making 75% of the original topsoil quality to be lost [4]. Commenting on the American Dust Bowl, US President Franklin D. Roosevelt said “The nation that destroys its soil, destroys itself”, a remark that is still relevant to modern crop management practices.
Storms, torrential rains, floods, and droughts are becoming more frequent and intense as a result of climate change. Every year, soil deterioration worsens, plants get stressed, and yields decrease. Soil management is, therefore, an essential element of sustainable agriculture.
Proper regenerative soil management will slow down or stop soil degradation and start to rebuild soil fertility. Management should be focused on obtaining healthy and superior plants that do not need intense chemical treatments since it is proven that a high immunity system protects crops from diseases and insect attacks. Increasing plant immunity will be pointed out in high yields, quality products, plants will get increased resistance to diseases and pest attacks. At the same time soil will become healthier, full of nutrients with an active and rich soil food web. Healthy soils with a balanced nutrients ratio, promote biological high activity and replenish groundwater, and will help the plants to withstand better the drought. To stop soil degradation, special attention must be paid to the phenomena that produce natural erosion, and rejuvenate the soil, while human activities have to change rapidly. Soil regeneration practices sequester an important part of the required amount of carbon in the soil, allowing mankind to maintain control over climate change. Soil carbon allows the land structure to function as a sponge, each gram of carbon-absorbing 8 grams of water. In addition to the positive effect on the mineralization process, carbon helps to build the soil structure, which aids in the supply of air, water, and nutrients to plants. Plants, in response, emit liquid carbon from their roots, increasing, even more, the synergies and water absorption. This phenomenon occurs more frequently when aggressive tilling works are avoided, and the synthetic fertilizer and synthetic biocides application are not used. The techniques, if they are applied indiscriminately have the opposite result, eliminating the carbon. Figure 1 depicts the most common approach to regenerative agriculture at three levels of management: acknowledge the objectives and benefits, comprehend the fundamental concepts, and put the best practices into action.
A simplified approach to regenerative agriculture implementation.
Regenerative agriculture requires a complete redesign of the farming system, as well as a shift in the procedures and metrics used in traditional agriculture, and a longer-term commitment of farmers.
FAO [5] defines soil degradation as a change in the soil health status, resulting in a diminished capacity of the ecosystem to provide goods and services for its beneficiaries. Degraded soils have a state of health that prevents them from generating the standard products and services in a given ecosystem. Soil degradation is caused by unfavorable interaction between physical, biological, and chemical soil characteristics, accelerating erosion, and leading to poor drainage, salinization, nutrient imbalance, decrease in soil organic matter, and suppressing biology. Physical soil deterioration includes changes in soil structure (crusting, compaction, etc.), imbalance in water content and air ratio, leading to extreme surface temperatures. Chemical soil deterioration includes nutrient leaching, fertility depletion, or even toxicity. Biological deterioration includes a decrease in the microorganism population and a drop in their activity, as well as, a severe reduction of organic matter content. Degraded soil is being studied at specialist institutions in nearly every country, and warnings are coming from all across the scientific world [6, 7, 8].
Major causes of soil degradation are divided into natural, as climate variations (soil degradation caused by wind, sun, drought, or heavy rains favoring the fertile soil to be washed away) and anthropogenic activities (overgrazing, deforestation, excessive use of chemicals fertilizers, pesticides, herbicides, bare soils, excess of tillage, overdraft of groundwater, etc.) [9].
Conventional agriculture is considered to be one of the biggest contributors to soil degradation [10]. After Second World War, the Chemical Industry provide agriculture with new and advanced chemical formulas used as fertilizers, herbicides, and pesticides. The first results showed great success for everyone; however, the long-term effects were not anticipated since they have affected over time the soil structure and soil food web. Over few decades, the soil became degraded, plants are now mostly unhealthy, animals and humans experience unexplained medical conditions, and yields are going down every year. Chemicals use and tillage technology are producing the most detrimental influence on soil deterioration; as a result, their usage must be closely monitored and, if possible, avoided.
Farmers, working in conventional agriculture, that usually apply intensive chemical technologies, come across many harmful practices like those described below. The practices described in this section aim to draw attention to the most common activities that farmers do voluntarily or unknowingly, which may lead to soil degradation and floods.
In Romania only a few farmers perform soil analysis annually, the majority of them use a standardized technology learned from books or advice from chemical companies. Soil parameters analyzed in a laboratory report do not contain enough information, the evaluation gives most often information regarding land chemistry, but ignores several important physical and biological properties. Sustainable agriculture changes the view of soil performance and soil quality [11]. Farmers need to invest more in complete soil assessment and perform some measurements by themselves, like soil acidity (pH) or soil conductivity (EC). The Haney report is another good analysis report that offers information about soil health, microbial respiration, water-extractable organic carbon, water-extractable nitrogen, etc. Haney soil test report offers farmers additional values to improve plant-available nutrients and estimate the soil health as related to carbon (C), nitrogen (N), and phosphorus (P) cycling [12].
Topsoil is being washed and lose its properties, microorganisms die, while its structure degrades. Uncovered soil favors natural soil erosion generated by rains, sun, or wind [13]. Soil loss of moisture and high soil temperature suppress bacteria and fungi living in the soil. In this environment, weeds germinate easily, and farmers cannot control them without using highly aggressive herbicides [14].
Tillage works as plowing and disking suppress the fungi network, appear losses the soil moisture, and may destroy soil structure [15]. Plowing is creating the hardpan at 15–30 cm deep. Hardpan is a compact layer of soil below the soil surface that inhibits roots movements through the soil [16]. Water is moving gravitationally on the hardpan, forming ponds, and soil gets salted [17].
Synthetic fertilizers suppress biology [18], contributing to soil compacting, loss of fertility, and humus total rate decrease. Plants are using only 15–30% of total inorganic fertilizers, while the rest is leaching in lakes, rivers, groundwater, etc. Accumulation of nitrogen in groundwater has different sources, being caught in irrigation lakes [19, 20]. As groundwater is the main source of drinking water, contamination poses several human health problems. At present in the United States of America, there are used 20 times more chemicals than in the American Dust Bowl period, and soil degradation continues dramatically.
Using in excess a specific nutrient especially N in a cation form, inhibits absorbing others nutrients cations as calcium (Ca), potassium (K), sodium (Na). The nutrient balance is one of the most important factors in plant nutrition [21, 22, 23], when plants receive too much N, during a 24 h photosynthesis process, N under forms of nitrate (NO3) or ammonium (NH4), is not transformed into proteins and became attractive for insects [24]. Excesses of N develop elongation, delay maturity, change biochemistry, cause plant stress and make plants vulnerable to drought [25].
Monoculture is not resilient to climate change, soil is losing carbon, while carbon dioxide (CO2) is increasing in the atmosphere. Monoculture is a source of scarcity because the diversity principle is strongly affected [26]. Monoculture combined with bare soil practices decreases the fertility of agricultural lands dramatically [27].
Groundwater overdraft is related to a dry aquifer, loss of water in streams and lakes, soil compacting, and polluted groundwater [27, 28].
If the biology of the soil is ignored in drought years, is a major problem, since the soil loses nutrients and water, putting plants under a high level of stress. The plant\'s nature enables to fill in the gap of water and nutrients. In recent decades, scientists from many laboratories have studied the interactions between microorganisms and plants, and they have concluded that the soil food web plays the most important role in plant nutrition [29].
In the last decades\' scientific reports demonstrated that micronutrients are as important as major elements, the only difference is the needed quantity. Micronutrient deficiency is widespread in the world due to low organic matter, bicarbonate content in irrigation water, long time of drought, and imbalanced application of fertilizers. Micronutrients application contribute to plant health, soil health, and increase yield by up to 15–50% [30, 31, 32].
There is no special interest nowadays in the quality of the products obtained in conventional agriculture [33]. Healthy plants that are resistant to illnesses, insect attacks, and drought are used to produce high-quality products, while also improving yields. Highly nutritional plants have a substantial positive impact on soil health [34], animal, and human health.
Regenerative Agriculture is organic agriculture, using only natural available resources. In organic agriculture, farmers are certified if they produce non-GMO plants without using synthetic chemicals, approaching soil conservation and preservation for biodiversity. Farmers are allowed to use only inputs from certified organic agriculture. In 2018, at Rodale Institute was introduced for the first time a new higher standard for the farmers working in a regenerative system called Regenerative Organic Certified (ROC) [35]. Regenerative Agriculture is the way to sustainable farming practice, regenerate soil fertility, grow healthy plants that create healthy soils, less sensible to draught. Using methods from Regenerative Agriculture technology, carbon is sequestered in the soil, soil structure and soil fertility improve, water retention, and crop yield increase, while drought and flood ameliorate [36]. Regenerative agriculture can be defined by a holistic system approach that starts with the soil characteristics and also includes the health of the plants, animals, farmers, and community. The main aims envisage to regenerate topsoil, restoring degraded soil biodiversity, enhancing ecosystem services, improving water cycling and improving the resilience of soil to extreme weather. Regenerative Agriculture focuses on improving soil health by following four main mandatory principles and one optional. All specialists in Regenerative Agriculture accept the four principles that include soil cover, living roots, biodiversity, and minimalizing soil disturbance. The last principle which is the integration of animals is partially accepted and can be even more important in a few specific situations.
Everything plants need is cycled by soil microorganisms before becoming available to plants\' roots. Earth life is based on photosynthesis, a process that transforms photonic energy into chemical energy. It varies, depending on the availability of light, water, carbon dioxide, chlorophyll concentration, and plant nutrition. Photosynthesis is the most efficient cycle and sustainable process in nature [37, 38], and it is the engine we can rely in Regenerative Agriculture. Farmers know that water, nitrogen, and high-temperature influence the photosynthesis process. During drought, plants switch from photosynthesis to photo-respiration process, when are consuming their reserve of proteins [39]. To avoid this happening, proper management has to be used that optimize nutrition. When monitoring fields frequently, one should notice nature needs [40].
Only a limited mechanical, chemical, and physical disturbance of soil is permitted. Tillage destroys soil structure, resulting in bare or compacted soil that is destructive to soil microorganisms and creates a hostile environment for them. Soil stability is a quantitative indicator of soil health that is based on a mix of biotic and abiotic soil parameters. The impact of physic and chemical qualities on soil resistance and resilience is mediated by the microbial community [41]. Living organisms in soil improve the structure, create pore spaces that allow water and air to infiltrate the soil. Intensive tillage destroys macro and microorganism habitat, disrupt the fungi hyphae and soil aggregate.
Synthetic fertilizers, herbicides, pesticides, and fungicides suppress life in the soil, having a negative impact on soil fertility. Inputs application disrupts the symbiotic relationships between fungi, bacteria, and plants roots. Overgrazing is a form of biological disturbance that reduces roots mass, increases soil temperature and runoff. All forms of soil disturbances affect microorganisms and diminish the soil food web.
The principle is oriented toward keeping soil covered at all times, especially by setting up cover crops or intercropping. This is a critical step toward rebuilding soil health because bare soil is not a normal state, nature always works to cover the soil surface. When providing a natural vegetal shield, the soil is protected from wind and water erosion, while providing foods and a habitat for macro- and microorganisms [42]. It will also prevent moisture evaporation, reduces temperature, intercepts raindrops, and reduces germination of weed seeds. Soil cover offers a habitat for soil food web members that spend some of their time above ground. Keeping the soil cover on allows microorganisms to break down leftovers while recycling nutrients back into the soil.
Nature aims for the diversity of both plant and animal species. Farmers should do the same, since monocultures are present only where humans have established them. The preservation, conservation, and restoring biodiversity should be a priority nowadays. Biodiversity is a major determinant in ecosystem stability, productivity, and nutrients dynamics. High diversity can be twice as productive as monoculture [43]. Different plant species use carbohydrates to feed certain microorganisms in return for water and nutrients via their roots. Biodiversity of plants is required to support the biodiversity of microbes. Each microorganism plays a specific role in maintaining soil health, and diversity enhances ecosystem functioning [44]. The key to improving soil health consists in a soil food web that is populated with several types of plants and animals. A fully functioning soil food web provides nutrients, water, energy, and allows the soil to express its full potential. The diversity has to be increased using crop rotation and cover crops.
Living roots have to be maintained in soil as long as possible because they are feeding soil biology by providing basic food source carbohydrates [45]. This biology feeds plants with water and nutrients, having the capacity to store nutrients and water that will be provided during drought. Farmers within conventional agriculture used to think there are 120 days to rest soil until the growing season. It is now considered wrong since living plants continue growing into early winter and break biological dormancy earlier in the spring. Their roots are feeding soil organisms and keep the biological population at a high rate. Healthy soil is dependent upon how well the food web is fed. Providing food to soil microbes helps them cycle nutrients that plants needed to grow.
Nature does not function well without animal organisms. Integrated livestock into an operation provides many benefits. The major benefit is that grazing stimulates the plants to pump more carbon into the soil. This drives nutrient cycling by feeding biology, also has a major positive impact on climate change by cycling more carbon out of the atmosphere and putting it into the ground. Pasture cropping is another way of practicing regenerative agriculture for growing food and restoring degraded soil. Farmers should provide a home and habitat not only for farm animals but also for pollinators, predator insects, earthworms, and all the microbiology that drive ecosystem function.
Monitoring the field every day is also a key factor in keeping plants healthy. Checking the soil compaction, earthworm activity, soil structure, erosion risks, poor crop growth, etc., and keeping a recording of everyday activity helps the agricultural management system. Minimum information recorded are data, weather, fertility and irrigation program, yield, insects attack, diseases, etc.
There are different technologies according to these principles that are already used by some farmers. The most commonly used are the NO-TILL or STRIP-TILL, but they are rather used for profit maximized than for reducing drought effect and regenerating soil health. NO-TILL is studied in many countries, over a long period of years, concluded that is a big step forward [46]. However, these technologies are included in regenerative agriculture methods of growing plants during drought. A special part that is additional to these methods in regenerative agriculture, concerns breaking the hardpan and biological inoculation.
Drought stress is reduced when plants are healthy and thrive in healthy soil. For plants to overcome the draught on degraded soils, a new management strategy is required. Water, balanced nutrients, and biology are the three most important requirements for plants. Plants that are well-managed produce soil that is rich in humus. Growing healthy plants to overcome the drought and the elements that impact the process are provided in the appropriate sequence.
The field control has to begin in the autumn before the new agricultural year begins. Weeds like quack grass and foxtail can be found in dry clay soil, indicating calcium deficits and compact soil. Mow the grasses and compost the cuttings into the soil to help with calcium deficits. Broadleaf weeds, like ragweed, indicate copper deficiencies problem, and a phosphate/potassium imbalance. The rate between phosphate and potassium should be 2/1 for row crops and 4/1 for grass crops. Succulent weeds increase soil water capacity, replenish carbonate ions while covering the ground to protect against soil erosion. Weeds role is to deposit nutrients and metabolites in the soil or rearrange the nutrients existing in the soil. There is plenty of information in the literature about weeds role and weeds usage as a soil indicator [47, 48, 49]. This information is important to design a fertilization plan, in order to balance the nutrients. Herbicides must be avoided as much as possible since weeds get resistant to synthetic inputs, plants get unhealthy while the microbial population will decrease. Brix index in plants leaf must be measured before foliar application and 2 h after. After a few foliar applications, the crop will thrive and weeds will be attacked by insects and diseases, and not the established culture. As the nutrients are balanced, pH changes and weeds are under control.
Hardpan management is the compact layer of soil just below the ground surface. Excess plowing leads to soil moisture loss by evaporation [50]. Avoiding working with moldboard plows, farmers must use instead a strip subsoil breaker in the first year to break the hardpan and apply a NO-TILL technology in the next years. Hardpan reduces the soil depth for plants roots and enhances soil waterlog. Plant roots grow in the surface layer reducing access to water and nutrients.
Well, aggregate soils are rarely found, usually, soils are crusted, compacted in layers or plow pans [51]. The agricultural year start in autumn and farmers first issue should be checking the hardpan with a penetrometer. After that, has to be measured the distance from soil surface to hardpan and hardpan thickness. If hardpan thickness is more than 5cm, then must be used a subsoil strip breaker. Soil improvement usually includes subsoil adding biological fertilization to break the hardpan and inoculate with microorganisms (bacteria, fungi) at the same time. Breaking the hardpan will allow water and nutrients to infiltrate deep in the ground, while microorganisms will keep the moisture and nutrients for a long period. Underground water and nutrients are stored naturally and through capillarity, the plants have access to water and nutrients during the drought period. In order to maintain the microbiology alive, they should be multiplied by feeding them and keeping constant moisture and temperature in the soil. In time, they will improve the soil structure, porosity, and the humus percentage will increase. In the photosynthesis process plants secret carbohydrates (sugar) and protein through the roots, which are food for bacteria and fungi. Bacteria and fungi are eaten by bigger microorganisms like nematodes and protozoa. Plants are thriving in such an environment even in drought conditions. With a restored soil food web, plants can control the water and nutrients cycling in the rhizosphere neighborhood. A restored food web reduces irrigation and tillage requirements, provides protection against pests and diseases and inhibits weeds. Pesticides and herbicides are not required, since applying these methods yields and farms profitability will be increasing.
Living life provides soil structure that resists wind and rain erosion. The first step will be in accordance with principles to use no plowing or disking, by implementing a no-till system. Figure 2 compares three types of agricultural soil processing: in the first plan the work was performed with soil loosening equipment, in the second plan it is proposed the minimal processing technology by breaking the hardpan, and in the third plan a plowed land is highlighted.
Comparison between three types of agricultural soil processing: soil loosening equipment (first plan); minimal processing technology-hardpan breaking (second plan); plowing (third plan).
The proposed technology within INMA institute is performed with an equipment that can be carried by an agricultural tractor, that cut the soil linearly without overturning the furrow, break the hardpan, and inoculate the ground with beneficial microorganisms. An active microorganism life restores the soil food web, which keep the pore open. This could be the first phase in rebuilding a healthy soil and ecosystem.
Amendment and treatments have a significant effect on soil\'s physical and chemical properties and increase microbial activity. Amendments improve soil water retention and soil structure as permeability, drainage, air holding capacity, etc. Soil acidity is potentially serious land degradation, acid soil is crusted and compacted, requires calcium, phosphorus, and minerals. The recommendation is to apply on soil a minimum 200 kg of lime and 200 kg of soft rock phosphates per hectare every autumn and spring during the first 2–3 years. These small quantities are recommended only in soils with degraded food web, or if microorganisms are being incorporated into the soil. Microorganisms are highly important because they break down the amendments and make them available to plants. High quantities of minerals suppress microorganisms. The amendments are spread best in autumn, before planting the cover crops and in spring before planting the main crop. Any other nutrient must be added as a result of the soil analysis. Organic amendments like compost or vermicompost have a benefic effect, increasing macro and micronutrient, organic matter, physical, and chemical soil properties like pH and EC. Humic acid found inside vermicompost, improves phytoremediation of soils contaminated with heavy metals [52]. Vermicompost soil amendments combined with foliar fertilizer, based on vermicompost, reduces the period to regenerate the soil fertility. Vermicompost can be produced in every farm, is cheap and have a tremendous effect on plants that grow during draught.
Plants need minimum 17 mineral nutrients divided into macro- and micronutrients to grow and complete plants\' life cycle. Each of the nutrients perform specific functions within the plant and the amount of each needed by the plant depends on what role the plant has each element [53, 54]. Microelements are needed in a small amount, but they are as important as macro-elements. Micronutrient deficiencies induce stress in plants, cause yield losses, resulting in poor health for animals and humans [29]. Supplying plants with micronutrients, through soil application or foliar spray, increases yields, produces higher quality, but also increases macronutrient use efficiencies. Micronutrients application is cheaper and needs less labor and transport because there are small quantities to manipulate. There are nine macronutrients nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg), sulfur (S), carbon (C), oxygen (O), and hydrogen (H) from which conventional agriculture is using six, but focus only on three N, P, K. Farmers in conventional agriculture, concentrating on NPK, can deliver excellent yields in irrigated conditions or rainy years, but less quality is usually obtained. Finite products, full of nutrients, for healthy animals and humans, are obtained when plants absorb balanced nutrients. To design a fertilizer plan, one need proper knowledge of the interaction between nutrients [55]. The key to controlling the mineral nutrients is restoring the soil food web. First-year must fertilize with biofertilizers and 70% of the recommended macronutrients N and P to obtain better yields and better-quality crops, low nitrate and nitrite levels in crops [56]. In two-three years, with a soil food web restored, microorganisms will takecare of plant nutrition, bacteria will fix the nitrogen in the soil, while other specific bacteria will solubilize the needed minerals. Biofertilizer is keeping beneficial microorganisms in the soil healthy and allow plants to overcome the drought [57].
Organic fertilizer is added to the soil to improve soil structure, feed both the plants and microorganisms. Microorganisms break down the organic materials and release nutrients slowly to the plants. Organic fertilizers increase soil\'s ability to hold water and nutrients. Solid organic fertilizer made from bat guano, fish meal, or manure can be spread on the soil before planting the main crop. Liquid fertilizer can be sprayed on soil or leaves. Chelated liquid fertilizer should be used for a slow-release technique. A cheap method is to spread the fertilizers in furrows, in this way, it will produce the same effect, but the quantity needed is much less (approximately 20–30% of the total quantity needed).
Seed inoculation is a cheap and beneficial tool to grow healthy plants, considering that each plant has a group of bacteria or fungi that work in association with the plant roots. The colonization of plants roots by associated bacteria and fungi result in better performance than plants colonized by the wild population of microorganisms [58]. Inoculations have to be performed for both the main crop and cover crop. Inside the cover crop, there have to be various legume seeds that can be inoculated with nitrogen-fixing bacteria. No need to fertilize the soil with nitrogen if seeds are inoculated with these types of bacteria [59, 60]. Biological control agents protect seedlings from disease as fusarium, pythium, etc. [61]. Arbuscular mycorrhizal fungi play an important role in plant growth. Corn inoculated with arbuscular mycorrhizal have a higher phosphorus absorption, increases vegetative biomass and grain yield, especially in low or medium available phosphorus [62].
Soil food web is a new model of soil fertility based on biology. This new model works better, presenting a lower cost, preventing diseases, do not pollute and use minimal chemical inputs [63]. Microorganisms are the link between water, nutrients and plants. Plants are in control of a viable soil food web, and exudates, in the form of carbohydrates and proteins, attracting specific bacteria and fungi. Bacteria and fungi consuming root exudates are at the bottom of the soil food web. Bigger microbes, nematodes, and protozoa are consuming bacteria and fungi, and are excreted as nutrients right in the rhizosphere. Protozoa and nematodes are eaten by arthropods. Arthropods may eat other arthropods or they might be eaten by snakes, birds, moles, etc. Worms, insect larvae, and moles are moving through the soil, in search of food, creating pathways and letting water and air enter. Members of the soil food web bind soil particles together, create tunnels for air and water to help create soil structure. Soil food web has a natural design and presents seven major benefits such as diseases suppression, nutrients retention, increase mineral nutrient availability to plants, improve soil structure, decomposition of toxic chemicals, production plant growth, and improve crop quality. Microorganisms and other soil food web members release root growing hormones. These growth hormones help the plant to cross the draught or a flood and increase yield.
The presence of plant cover crops in the agricultural system aids in the production of large amounts of biomass. This boosts the soil\'s organic content, improving fertilization. The physical, chemical and biological qualities of the soil are improved by maintaining permanent cover crops, and in time, contributing to the restoration of its health. It is recommended to use biodiversity, which include at least one species of leguminous plants. Inoculation has to be achieved with nitrogen-fixing bacteria, especially for leguminous plants. Then the amendments can be spread and may plant various cover crop seeds. Incorporation of amendments can be done with a disk harrow, while the cover crops may consist of oats, rye, buckwheat, radish, mustard, vetch, clover, etc. Plants\' biodiversity will attract various bacteria and fungi, each plant species attracting its own specific microorganisms. In this way, the soil food web will be restored sooner and better. Cover crops have to be chopped or mowed in spring before full bloom, and a minimum of two weeks before planting the main crop. The cover crop will maintain the soil moisture, while soil temperature will not vary too much during drought or between day and night. After mowing, cover crops are used as mulch. Raindrop energy will be dissipated by living crops and mulch, and in this way, erosion will be under control. Cover crops are being decomposed by fungi and bacteria. Another advantage is that in winter cover crops are one of the best options to defend against topsoil loss due to erosion. If it is managed correctly, the decomposition of cover crops by bacteria and fungi provides nutrients to the main crop (cash crop), while biodiversity of cover crop suppresses weeds, prevents NO3 leaching and produces above-ground biomass N [64, 65]. Plant diversity helps to reduce pathogens, pests, and weed invasion, reducing the need for insecticides and pesticides.
A diversified crop rotation enhances soil structure by varying the length of planting zones, allowing for better water penetration. Different crops with varying nutrient requirements, as well as waste products, will help to create a more balanced and resilient soil ecosystem. The duration of these rotations is usually between 4 and 6 years.
When sowing, it is recommended to inoculate the main crop seeds with different solutions based on microorganisms and nutrients. The seeding should start in spring, two weeks after mowing the cover crops and apply foliar fertilizer during the critical point of influence. Each crop has different important phases that may be influenced by inoculation with microorganisms: when planting (to enhance germination), strengthening plant structure, growing the fruit and finishing fructification. Foliar fertilizer must contain at least calcium, manganese, boron, zinc, amino acids. Balance calcium with potassium starting filing fruit point of influence and replace calcium with potassium at the finishing fruit. Get the maximum feedback from the plant when adding biology in the fertilizer solution. A healthy plant will cross the drought. Harvest the corn seeds, but let the corn stalk on the soil to be decomposed by fungi and bacteria.
Foliar application is the most efficient and cheap way to grow healthy plants. Growing healthy plants increase the immune plants\' system, get resistance to diseases and insects attack, plants can cross the drought. In order to grow healthy plants, increase the photosynthesis process from 2- to 3 times by using the right foliar fertilizer solution. Aerated compost tea is a foliar biofertilizer with a benefic impact on plant growth [66]. Inside the aerated compost tea add other nutrients needed by plants.
A complete foliar fertilizer contains clean water, mineral nutrients, microorganisms, plant bio-stimulants, bacteria bio-stimulants, fungi bio-stimulants, and inoculants. It has a synergetic effect on plant growth. Plant reaction is tremendous, especially in degraded soils.
Water is the most important ingredient in foliar fertilizer solution. Using poor-quality water can determine a loss of 50% from the effect of the foliar solution. Do not use water from ponds, lakes, or others sources without water analysis tests. Good water for foliar application has less than 70 ppm, pH between 5.2 and 6.5, electrical conductivity EC between 1.6 and 2.8 ds/mm and temperature between 58 and 78 degrees Fahrenheit. For best results use rainwater or reverse osmosis water. Municipality water is usually unsuitable for foliar recipes because of the chlorine or chloramine, with high pH and potentially hardness.
Foliar solution when humidity is high has to be applied in larger particles (not fine spray), so the liquids remain on the leaf surface a long time without drying out. Sprayers with large droplets make a huge difference. The farmer should measure the effect of the foliar solution before application and 2 h after. If Brix reading is 2 points higher, the foliar solution is good and could apply on the entire field. A diagram of the Brix index reading should be done for every crop. Around 8 o’clock in the morning, after collecting healthy old mature leaf samples from 10 to 20 plants, they are squeezed on a refractometer.
In the Brix diagram example, the values are starting from 5, increasing to 9 at the first foliar application, but dropping after a few days to 6. After repeating the foliar application, the Brix index increases to 11, but drop in a few more days to 7. Every time when a good foliar application is applied, the Brix readings are higher and has been found that when Brix values are over 12, the plants present a health status that helps them overcome more easily the drought.
A refractometer gives general information about plant health, but for more information including nutrients balance, a sap analysis is necessary. Plant sap analysis provides 21 nutrients parameters values that enable farmers to optimize the crops\' fertilization plan. The information is valuable because the uptake of plant nutrients are revealed in a few hours, the increasing performance can be tracked graphically, similar to the example shown in Figure 3. To a better understanding, one can compare a sap plant analysis with human blood analysis. A plant sap analyze tells the current uptake of nutrients, excesses or deficiencies of nutrients long term before can be seen on a plant leaf, plant reserves of nutrients, nutrient imbalance in soil, what nutrient plant can use at that moment for its own growth, or even fruit quality [67]. Sap analysis laboratory in less than one week will provide the analysis sheet with a fertilizer plan recommended. A balanced mineral uptake increases plants\' health that gets resistant to diseases and insects attack and crosses the drought.
Example of the variation of the Brix index for tomato juice, for a period of 30 days.
Water is the most important nutrient for plants. A source of water is critical for drought years, but as long as the regenerative methods presented are met, plants can cross the draught without an irrigation water source. Knowledge of irrigation water quality is critical in understanding long-term soil management. The most influential water parameter is the salinity measured by electrical conductivity EC [68]. High sodium related to calcium and magnesium contends, in irrigation water, causes surface crusting, pore plugging, swelling, and dispersion of soil clay. The acidity or basicity of irrigation water is expressed as pH. Normal irrigation pH is between 6.5 and 8.5. Specific ions like boron, sulfate, chloride, and nitrate, may affect plants grown. An irrigation water analysis is required.
Keep a crop rotation, with cover crop intermediate, for minimum 3 years after starting your regeneration soil program. After concluding that the soil food web is active and the soil is healthy crop rotation is not as important anymore, since biology will take care of plant nutrition and will suppress diseases, insects attack will decrease.
Aerated compost tea, produced by a compost tea brewer, allow microorganisms to be extracted from compost and multiplied. The result consists in beneficial aerobic microorganism production that provides plants with nutrients and helps build the soil food web [69]. The tea is used for spraying both the leaf and soil. Vermicompost is also used to avoid pathogens. Red worm castings are free of pathogens. There are farmers, involved in regenerative agriculture, buying different products that contained few families of fungi and bacteria, but inside aerated compost tea there are thousands of families. A compost tea brewer can be purchased or can easily be built. All a farmer needs is a tank, an air pump, a hose, and an air splitter distributor. To brew the compost needs clean water, vermicompost, mineral nutrients and bio-stimulants for plants, bacteria and fungi. Brew all these ingredients for 24–36 h, then measure the pH and EC. If pH is higher than 6.5 must add 100–300 ml of vinegar and measure again. When measuring EC a few hours before stopping the air pump, If the values are too low must add more vermicompost. The tea has to be used within 4 h after the air pump stops, to improve the synergetic effect on plants and soil [70].
Good and efficient management of animal grazing can rebuild soil health. This is a way for a healthy ecosystem, farm profitability, human health, food system resilience. Studies that use a complementary approach to animal husbandry with organic farming use found that adopting some grazing strategies could regenerate the soil and make them more profitable. Holistic management of livestock management includes grazing, land, and financial planning and ecological monitoring.
Agroforestry can provide suitable tools for landscape restauration because it can enhance physical, chemical, and biological soil characteristics. Agroforestry is restoring and increasing land productivity because the presence of the trees can fix nitrogen, stabilize the soil, reduce soil erosion, increase fertility, and regulate water available in degraded lands.
Trees increase fertility by retrieving nutrients from deeper soils and adding them to the soil surface through the leaf litter. Because of their deep root system, trees prevent nutrients from leaching, combat soil salinization, and acidification. The use of trees with fixing-nitrogen bacteria is increasing crop productivity. Experiments in Zambia, for example, showed that maize yields increased by 88–190% when grown in an agroforestry system under a canopy of
Trees can reduce and prevent soil erosion planted in windbreaks trees protect soil from erosion and increase yield.
Agroforestry buffer strips increase water runoff, and soil evaporation and increase water infiltration and water retention capacity, helping plants to cross the drought.
Minimum instrumentation required to grow healthy plants and cross the draught more easily is the penetrometer, refractometer, pH-meter, EC-meter. A penetrometer is the first instrument to be used in an agricultural season to measure soil compaction. The penetrometer is a device used to measure the resistance of soil to a vertical force. The penetrometer can determine the depth of the hardpan and help producers to determine if a subsoil is in need.
Refractometer measure Brix index values for liquids. Brix values indicate the total soluble solids. The refractometer is widely used in measuring the quality of the grapefruits and the time to harvest. The refractometer can be used to evaluate the overall assessment of plant health. Healthy plants with a minimum 12 Brix readings are resistant to diseases and insect attacks.
Soil pH-meter is used to measure the acidity or alkalinity of soil. The values give information about the balance of the nutrients found in the soil. However, can be also used as a pH meter for liquids, and determine pH when adding 5 parts distilled water on 1 part of the soil.
EC (electrical conductivity) meter is used especially to estimate salinity levels. A high level of salinity reduces the plant\'s ability to take up water. For assessment is being used 5 parts distilled water and 1 part soil to determine the values of salinity in mSiemens/cm. In clay soils, values are between 0.2 and 1.0 mS/cm, but different plants tolerate different values.
During drought, when air temperature became too warm, plants switch from photosynthesis to photo-respiration and begin consuming their inside proteins. Healthy plants with a waxy sheen, on the leaf surface, have a cooler leaf temperature than plants with a lack nutritional integrity. Foliar applications with teas made from compost, with the addition of 3 L of molasses per hectare, during and after the drought, is a very good practice.
Regenerative agriculture is focused on farming techniques with the primary goal of regenerating the land, particularly increasing the organic composition in order to improve fertility. This strategy conserves and restores soil organic matter, thus, influencing the development and prosperity of micro- and macro-organisms with beneficial results against soil erosion and drought.
Farmers may be forced to adopt unsustainable practices due to economic pressures, as they rarely have enough ability to deal with the conditions imposed by larger corporations, that control prices and credit. As a result, agricultural policies must be implemented at the national level to assist farmers and ensure they are not compelled to deplete the resource that provides them with a means of subsistence.
Regenerative agriculture is based on a holistic approach that places the land at the core of the process to produce efficiently and sustainably a synergy between the soil, the animal world, and the plant world. This enables the development of food chains between all three ecosystems, while the restoration of soil health is ensured by the balance and diversity of species found within the environment.
Climate change is no longer a myth, but a fact and the consequences are becoming increasingly severe every day, influencing the drought phenomena. Every year, topsoil is leaching, soil gets compacted, crusted, loses the ability to supply nutrients and water to plants. Degraded soils, in drought conditions, are not able to support plants with the required water and nutrients, while yields decrease dramatically. In order to reduce the drought effect, farmers have to integrate their use of regenerative agriculture principles and methods, focusing on growing healthy plants and getting rewarded with good yields and increased farm profitability.
Water retention in agricultural lands is associated with soil organic carbon and is influenced by soil health. Soil organic carbon increases the percentage of water retention because carbon acts like a sponge that absorbs moisture. Regenerative management practices such as minimum tillage, cover crops, inoculation with microorganisms, mulching practices, nutrients cycling, maintenance of an optimal balance of organic fertilizers, foliar application, and other methods help to increase soil organic carbon. This strategy restores degraded soils, enhances biomass production, purifies groundwater, reduces the rate of CO2 emissions into the atmosphere and increases the percentage of water being retained in the soil.
An active soil food web is the link between water, nutrients, and plants. Healthy soils have an active soil food web that presents many benefits such as diseases suppression, nutrient retention, improve soil structure, making mineral nutrients available to plants, decomposition of toxic materials, improve crop quality. Soil food web works in synergy with plants and helps crops to overcome more easily drought or floods.
The primary goal of this technology is to grow healthy plants on a worldwide scale. Healthy plants achieve synergies with the soil and improve its health, recover carbon in the soil, increase water retention, and improve soil structure and nutritional status. Drought years will be more profitable for farmers using regenerative agriculture technology, since organically grown cereal prices will be higher, resulting in greater average yields. In a short period of time, farmers using regenerative agriculture technology will spend less money, yields will grow, profitability will increase, soils will regenerate, and drought years will become less risky.
General requirements for Open Access to Horizon 2020 research project outputs are found within Guidelines on Open Access to Scientific Publication and Research Data in Horizon 2020. The guidelines, in their simplest form, state that if you are a Horizon 2020 recipient, you must ensure open access to your scientific publications by enabling them to be downloaded, printed and read online. Additionally, said publications must be peer reviewed.
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Intermetallic compounds are usually formed when alloying elements, such as Fe, Cu, Mn, Mg and Sr. are added to Al-Si based alloys. These elements are depicted by X in the alloys formation expression. The chapter noted that the most common intermetallics are iron (Fe) based, and several of these Fe-phases, including the most harmful Fe-phase, β-Al5SiFe, are listed and discussed. Fe-phase intermetallics are deleterious to the mechanical properties of Al-alloys; however, addition of <0.7% Fe helps prevent soldering in die casting mould. The effects of Fe-phase and other intermetallics formed by Cu, Mg and Mn were examined. Further, some techniques of eliminating or mitigating the negative influences of intermetallics were discussed.",book:{id:"6134",slug:"intermetallic-compounds-formation-and-applications",title:"Intermetallic Compounds",fullTitle:"Intermetallic Compounds - Formation and Applications"},signatures:"Williams S. Ebhota and Tien-Chien Jen",authors:[{id:"206268",title:"Dr.",name:"Williams",middleName:"S.",surname:"Ebhota",slug:"williams-ebhota",fullName:"Williams Ebhota"},{id:"214786",title:"Prof.",name:"Tien-Chien",middleName:null,surname:"Jen",slug:"tien-chien-jen",fullName:"Tien-Chien Jen"}]},{id:"54395",doi:"10.5772/67514",title:"Fundamentals of Chemical Vapor Deposited Graphene and Emerging Applications",slug:"fundamentals-of-chemical-vapor-deposited-graphene-and-emerging-applications",totalDownloads:3548,totalCrossrefCites:5,totalDimensionsCites:14,abstract:"Graphene, the atomically thin sheet of sp2 hybridized carbon atoms arranged in honeycomb structure, is becoming the forefront of material research. The chemical vapor deposition (CVD) process has been explored significantly to synthesis large size single crystals and uniform films of monolayer and bilayer graphene. In this prospect, the nucleation and growth mechanism of graphene on a catalytic substrate play the fundamental role on the control growth of layers and large domain. The transition metals and their alloys have been recognized as the active catalyst for growth of monolayer and bilayer graphene, where the surface composition of such catalysts also plays critical role on graphene growth. CVD-synthesized graphene has been integrated with bulk semiconductors such as Si and GaN for the fabrication of solar cells, photodetectors, and light-emitting diodes. Furthermore, CVD graphene has been integrated with hexagonal boron nitride (hBN) and transition metal dichalcogenides (TMDCs) for the fabrication of van der Waals heterostructure for nanoelectronic, optoelectronic, energy devices, and other emerging technologies. The fundamental of the graphene growth process by a CVD technique and various emerging applications in heterostructure devices is discussed in detail.",book:{id:"6215",slug:"graphene-materials-advanced-applications",title:"Graphene Materials",fullTitle:"Graphene Materials - Advanced Applications"},signatures:"Golap Kalita and Masaki Tanemura",authors:[{id:"17333",title:"Dr.",name:"Masaki",middleName:null,surname:"Tanemura",slug:"masaki-tanemura",fullName:"Masaki Tanemura"},{id:"195869",title:"Dr.",name:"Golap",middleName:null,surname:"Kalita",slug:"golap-kalita",fullName:"Golap Kalita"}]},{id:"39648",doi:"10.5772/51514",title:"Fundamental Aspects of Silicon Carbide Oxidation",slug:"fundamental-aspects-of-silicon-carbide-oxidation",totalDownloads:4371,totalCrossrefCites:6,totalDimensionsCites:13,abstract:null,book:{id:"3129",slug:"physics-and-technology-of-silicon-carbide-devices",title:"Physics and Technology of Silicon Carbide Devices",fullTitle:"Physics and Technology of Silicon Carbide Devices"},signatures:"Heiji Watanabe and Takuji Hosoi",authors:[{id:"153696",title:"Prof.",name:"Heiji",middleName:null,surname:"Watanabe",slug:"heiji-watanabe",fullName:"Heiji Watanabe"}]},{id:"37701",doi:"10.5772/50748",title:"Thermal Oxidation Mechanism of Silicon Carbide",slug:"thermal-oxidation-mechanism-of-silicon-carbide",totalDownloads:3525,totalCrossrefCites:6,totalDimensionsCites:11,abstract:null,book:{id:"3129",slug:"physics-and-technology-of-silicon-carbide-devices",title:"Physics and Technology of Silicon Carbide Devices",fullTitle:"Physics and Technology of Silicon Carbide Devices"},signatures:"Yasuto Hijikata, Shuhei Yagi, Hiroyuki Yaguchi and Sadafumi Yoshida",authors:[{id:"18137",title:"Dr.",name:"Yasuto",middleName:null,surname:"Hijikata",slug:"yasuto-hijikata",fullName:"Yasuto Hijikata"},{id:"18271",title:"Prof.",name:"Hiroyuki",middleName:null,surname:"Yaguchi",slug:"hiroyuki-yaguchi",fullName:"Hiroyuki Yaguchi"},{id:"18272",title:"Dr.",name:"Sadafumi",middleName:null,surname:"Yoshida",slug:"sadafumi-yoshida",fullName:"Sadafumi Yoshida"},{id:"152822",title:"Dr.",name:"Shuhei",middleName:null,surname:"Yagi",slug:"shuhei-yagi",fullName:"Shuhei Yagi"}]},{id:"60330",doi:"10.5772/intechopen.74176",title:"Preclinical Aspects on Magnetic Iron Oxide Nanoparticles and Their Interventions as Anticancer Agents: Enucleation, Apoptosis and Other Mechanism",slug:"preclinical-aspects-on-magnetic-iron-oxide-nanoparticles-and-their-interventions-as-anticancer-agent",totalDownloads:1325,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"The broad area of magnetic iron oxide nanoparticle (M-IONP) applications and their exclusive physico-chemical characteristics (superparamagnetic properties per se, solubility and stability in aqueous solutions, and high bioavailability in vivo) make these nanoparticles suitable candidates for biomedical uses. The most employed magnetic iron oxides in the biomedical field are magnetite and maghemite. Cancer represents a complex pathology that implies multiple mechanisms and signaling pathways, this complexity being responsible for the increased resistance to therapy and the lack of an effective curative treatment. A potential useful alternative was considered to be the use of magnetic iron nanoparticles. The M-IONPs proved to be effective as contrast agents in magnetic resonance imaging, as drug delivery carriers for different therapeutic agents, in magnetic cell separation assays, and are suitable to be engineered in terms of size, targeted delivery and substance release. Moreover, their in vivo administration was considered safe, and recent studies indicated their efficiency as anticancer agents. This chapter aims to furnish an overview regarding the physico-chemical properties of M-IONPs (mainly magnetite, maghemite and hematite), the synthesis methods and their in vitro biological impact on healthy and cancer cell lines, by describing their potential mechanism of action—enucleation, apoptosis or other mechanisms.",book:{id:"6335",slug:"iron-ores-and-iron-oxide-materials",title:"Iron Ores and Iron Oxide Materials",fullTitle:"Iron Ores and Iron Oxide Materials"},signatures:"Elena-Alina Moacă, Elena Dorina Coricovac, Codruta Marinela\nSoica, Iulia Andreea Pinzaru, Cornelia Silvia Păcurariu and Cristina\nAdriana Dehelean",authors:[{id:"141027",title:"Dr.",name:"Cristina",middleName:null,surname:"Dehelean",slug:"cristina-dehelean",fullName:"Cristina Dehelean"},{id:"173283",title:"Dr.",name:"Dorina",middleName:null,surname:"Coricovac",slug:"dorina-coricovac",fullName:"Dorina Coricovac"},{id:"186678",title:"Dr.",name:"Codruta",middleName:null,surname:"Soica",slug:"codruta-soica",fullName:"Codruta Soica"},{id:"217849",title:"Associate Prof.",name:"Iulia Andreea",middleName:null,surname:"Pinzaru",slug:"iulia-andreea-pinzaru",fullName:"Iulia Andreea Pinzaru"},{id:"219727",title:"Mrs.",name:"Elena Alina",middleName:null,surname:"Moaca",slug:"elena-alina-moaca",fullName:"Elena Alina Moaca"},{id:"219728",title:"Prof.",name:"Cornelia Silvia",middleName:null,surname:"Pacurariu",slug:"cornelia-silvia-pacurariu",fullName:"Cornelia Silvia Pacurariu"}]}],mostDownloadedChaptersLast30Days:[{id:"58868",title:"Iron Ore Pelletizing Process: An Overview",slug:"iron-ore-pelletizing-process-an-overview",totalDownloads:4575,totalCrossrefCites:5,totalDimensionsCites:9,abstract:"The iron ore production has significantly expanded in recent years, owing to increasing steel demands in developing countries. However, the content of iron in ore deposits has deteriorated and low-grade iron ore has been processed. The fines resulting from the concentration process must be agglomerated for use in iron and steelmaking. This chapter shows the status of the pelletizing process with a special focus on binders. Bentonite is the most used binder due to favorable mechanical and metallurgical pellet properties, but it contains impurities especially silica and alumina. The importance of many researches concerning alternative binders is also discussed in this chapter. Better quality wet, dry, preheated, and fired pellets can be produced with combined binders, such as organic and inorganic salts, when compared with bentonite-bonded pellets. While organic binders provide sufficient wet and dry pellet strengths, inorganic salts provide the required preheated and fired pellet strengths.",book:{id:"6335",slug:"iron-ores-and-iron-oxide-materials",title:"Iron Ores and Iron Oxide Materials",fullTitle:"Iron Ores and Iron Oxide Materials"},signatures:"Sandra Lúcia de Moraes, José Renato Baptista de Lima and Tiago\nRamos Ribeiro",authors:[{id:"216788",title:"Dr.",name:"Sandra",middleName:"Lúcia",surname:"De Moraes",slug:"sandra-de-moraes",fullName:"Sandra De Moraes"},{id:"233466",title:"Prof.",name:"José Renato Baptista",middleName:null,surname:"De Lima",slug:"jose-renato-baptista-de-lima",fullName:"José Renato Baptista De Lima"},{id:"233467",title:"MSc.",name:"Tiago Ramos",middleName:null,surname:"Ribeiro",slug:"tiago-ramos-ribeiro",fullName:"Tiago Ramos Ribeiro"}]},{id:"58937",title:"Intermetallics Formation and Their Effect on Mechanical Properties of Al-Si-X Alloys",slug:"intermetallics-formation-and-their-effect-on-mechanical-properties-of-al-si-x-alloys",totalDownloads:1854,totalCrossrefCites:11,totalDimensionsCites:22,abstract:"This study focuses on primary impurities, called intermetallics, in the microstructure of Al-Si-X alloys, their formation, effects and treatments to eliminate or ameliorate their deleterious effects. Intermetallic compounds are usually formed when alloying elements, such as Fe, Cu, Mn, Mg and Sr. are added to Al-Si based alloys. These elements are depicted by X in the alloys formation expression. The chapter noted that the most common intermetallics are iron (Fe) based, and several of these Fe-phases, including the most harmful Fe-phase, β-Al5SiFe, are listed and discussed. Fe-phase intermetallics are deleterious to the mechanical properties of Al-alloys; however, addition of <0.7% Fe helps prevent soldering in die casting mould. The effects of Fe-phase and other intermetallics formed by Cu, Mg and Mn were examined. Further, some techniques of eliminating or mitigating the negative influences of intermetallics were discussed.",book:{id:"6134",slug:"intermetallic-compounds-formation-and-applications",title:"Intermetallic Compounds",fullTitle:"Intermetallic Compounds - Formation and Applications"},signatures:"Williams S. Ebhota and Tien-Chien Jen",authors:[{id:"206268",title:"Dr.",name:"Williams",middleName:"S.",surname:"Ebhota",slug:"williams-ebhota",fullName:"Williams Ebhota"},{id:"214786",title:"Prof.",name:"Tien-Chien",middleName:null,surname:"Jen",slug:"tien-chien-jen",fullName:"Tien-Chien Jen"}]},{id:"54372",title:"Photoinduced Pseudospin Dynamical Effects in Graphene-Like Systems",slug:"photoinduced-pseudospin-dynamical-effects-in-graphene-like-systems",totalDownloads:1644,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"In this chapter, we describe some of our recent results on the laser-induced manipulation of the energy band structure of graphene-like systems. We present numerical results on the quasi-energy spectrum as well as detailed calculations of semi-analytical approximations to other physical quantities of interest. The main message we would like to convey to the interested reader of the chapter is that by properly tuning the perturbation parameters of the radiation field one can control the size and shape of the photoinduced gaps. These in turn would allow the realization of new electronic phases on graphene and its related materials such as silicene.",book:{id:"5722",slug:"graphene-materials-structure-properties-and-modifications",title:"Graphene Materials",fullTitle:"Graphene Materials - Structure, Properties and Modifications"},signatures:"Alexander López and Benjamin Santos",authors:[{id:"195536",title:"Dr.",name:"Alexander",middleName:null,surname:"López",slug:"alexander-lopez",fullName:"Alexander López"},{id:"204551",title:"MSc.",name:"Benjamin",middleName:null,surname:"Santos",slug:"benjamin-santos",fullName:"Benjamin Santos"}]},{id:"58482",title:"Calcination and Pelletizing of Siderite Ore",slug:"calcination-and-pelletizing-of-siderite-ore",totalDownloads:1279,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In the present study, calcination properties of Hekimhan-Deveci siderite (FeCO3) ore and the effect of calcination process before the pelletization on strength of pellet were investigated and evaluated. Two different calcination processes were followed. One of them is the traditional calcination process and the other one is microwave assisted calcination process which is a new process for siderite ore. The characterization of the calcined and uncalcined siderite ore was done using X-ray diffraction, X-ray fluorescence spectrometry and thermogravimetric analysis. The physical and mechanical properties of pellets which were obtained using the raw siderite and the calcined siderite were compared with each other. As a result of experimental studies, it was found that the calcination process decreased the milling time, causing the significant energy saving and the most suitable calcination process for siderite ore was found as 15 min at 700°C temperature. It was the first time that the calcination process of the siderite ore was achieved by microwave by adding 30 wt% sucrose as a thermal auxiliary. The microwave conditions were determined as 900 W at 3 min. In 3 min, the temperature of the siderite ore increased up to 1100°C and 32.14% weight loss for the sample was achieved.",book:{id:"6335",slug:"iron-ores-and-iron-oxide-materials",title:"Iron Ores and Iron Oxide Materials",fullTitle:"Iron Ores and Iron Oxide Materials"},signatures:"Mehmet Celikdemir, Musa Sarikaya, Tolga Depci, Ramazan\nAydogmus and Aysegul Yucel",authors:[{id:"212301",title:"M.Sc.",name:"Mehmet",middleName:null,surname:"Çelikdemir",slug:"mehmet-celikdemir",fullName:"Mehmet Çelikdemir"},{id:"213405",title:"Prof.",name:"Musa",middleName:null,surname:"Sarikaya",slug:"musa-sarikaya",fullName:"Musa Sarikaya"},{id:"213412",title:"Prof.",name:"Tolga",middleName:null,surname:"Depci",slug:"tolga-depci",fullName:"Tolga Depci"},{id:"213413",title:"MSc.",name:"Ramazan",middleName:null,surname:"Aydoğmuş",slug:"ramazan-aydogmus",fullName:"Ramazan Aydoğmuş"},{id:"227119",title:"MSc.",name:"Ayşegül",middleName:null,surname:"Yücel",slug:"aysegul-yucel",fullName:"Ayşegül Yücel"}]},{id:"69224",title:"Introductory Chapter: Cobalt Compounds and Applications",slug:"introductory-chapter-cobalt-compounds-and-applications",totalDownloads:761,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"8886",slug:"cobalt-compounds-and-applications",title:"Cobalt Compounds and Applications",fullTitle:"Cobalt Compounds and Applications"},signatures:"Aynur Manzak and Yasemin Yildiz",authors:[{id:"208129",title:"Dr.",name:"Yasemin",middleName:null,surname:"Yıldız",slug:"yasemin-yildiz",fullName:"Yasemin Yıldız"}]}],onlineFirstChaptersFilter:{topicId:"950",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:48,paginationItems:[{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"81681",title:"Immunomodulatory Effects of a M2-Conditioned Medium (PRS® CK STORM): Theory on the Possible Complex Mechanism of Action through Anti-Inflammatory Modulation of the TLR System and the Purinergic System",doi:"10.5772/intechopen.104486",signatures:"Juan Pedro Lapuente",slug:"immunomodulatory-effects-of-a-m2-conditioned-medium-prs-ck-storm-theory-on-the-possible-complex-mech",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science and Technology from the Department of Chemistry, National University of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013. She relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the National Institute of Fundamental Studies from April 2013 to October 2016. She was a senior lecturer on a temporary basis at the Department of Food Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is currently Deputy Principal of the Australian College of Business and Technology – Kandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI) Ambassador to Sri Lanka.",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. 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He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. 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He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University, Kuwait. 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After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:"Beijing University of Technology",institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Lakhno Igor Victorovich was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPhD – 1999, Kharkiv National Medical Univesity.\nDSc – 2019, PL Shupik National Academy of Postgraduate Education \nLakhno Igor has been graduated from an international training courses on reproductive medicine and family planning held in Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor of the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s a professor of the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics and gynecology department of Kharkiv Medical Academy of Postgraduate Education . He’s an author of about 200 printed works and there are 17 of them in Scopus or Web of Science databases. Lakhno Igor is a rewiever of Journal of Obstetrics and Gynaecology (Taylor and Francis), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for DSc degree \\'Pre-eclampsia: prediction, prevention and treatment”. Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: obstetrics, women’s health, fetal medicine, cardiovascular medicine.",institutionString:"V.N. Karazin Kharkiv National University",institution:{name:"Kharkiv Medical Academy of Postgraduate Education",country:{name:"Ukraine"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRZkkQAG/Profile_Picture_2022-05-09T12:55:18.jpg",biography:null,institutionString:null,institution:null},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/415531",hash:"",query:{},params:{id:"415531"},fullPath:"/profiles/415531",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()