Po-Shiuan Hsieh

National Defense Medical Center

Dr. Po-Shiuan Hsieh is currently a Professor and Director at the Institute of Preventive Medicine, National Defense Medical Center in Taiwan. His research interests focus on obesity and weight control as well as the pathological links between obesity, metabolic syndrome, and type 2 diabetes, especially the causal links between the major characteristics of metabolic syndrome, the role of inflammation in the development of insulin resistance and impairment of pancreatic insulin secretion in type 2 diabetes; the involvement of hepatic inflammation in the pathogenesis of type 2 diabetes; and the potential therapeutic application in prevention and treatment of metabolic syndromes and diabetes. He has served as the President of the Chinese Physiology Society from 2012 to 2016. He is also the editor-in-chief of two international journals: Chinese Journal of Physiology (SCI) and Journal of Medical Science.

3chapters authored

Chapters authored

Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance

By Po-Shiuan Hsieh

Part of the book: Role of the Adipocyte in Development of Type 2 Diabetes

The Role of Adipocyte Hypertrophy and Hypoxia in the Development of Obesity-Associated Adipose Tissue Inflammation and Insulin Resistance

By Pei-Chi Chan and Po-Shiuan Hsieh

Adipose tissue inflammation has been suggested to play a central role in the pathogenesis of many obesity-associated complications including insulin resistance and type 2 diabetes. Adipocyte hypertrophy and hypoxia especially in morbid obesity are the important sources for the development of adipose tissue inflammation. This inflammation is mediated by producing a large number of cytokines and chemokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1), and regulated upon activation, normal T-cell expressed and secreted (RANTES). Of note, these cytokines and chemokines produced by adipocytes during hypertrophy and hypoxia are crucially involved in the initiation and development of obesity-associated inflammatory response in adipose tissue. The capacity of constitutive and regulated release of immune mediators from adipocytes demonstrates a causal link between the biology of adipocytes and immune cells, such as macrophages and T cells. Moreover, the synergistic effect of hypertrophic, hypoxia adipocytes, and adipose tissue immune cells has also been implicated in the development of obesity-induced insulin resistance. This chapter provides the overall review and update evidence to highlight the important role and possible underlying mechanism of adipocyte hypertrophy and hypoxia in the development of obesity-associated adipose tissue (AT) inflammation and insulin resistance.

Part of the book: Adiposity

Prologue: Energy Metabolism and Weight Control

By Po-Shiuan Hsieh

Part of the book: Cellular Metabolism and Related Disorders

Po-Shiuan Hsieh

Chapters authored

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