Azza El-Sheikh

Dr. Azza Ali Kamel El-Sheikh was granted a 4-years scholarship by the Egyptian Ministry of Higher Education to get her PhD degree from the Netherlands. She had obtained her bachelor degree of Medicine and Surgery in December 1993, and her Master degree in Pharmacology and Toxicology in 1998 from El-Minia University (Egypt). She worked as an assistant lecturer in the same department till November 2004, where she started her PhD at the department of Pharmacology and Toxicology, Radboud University Nijmegen, The Netherlands. During her PhD period, she received several prizes. In April 2006, she was awarded the prize for best discussion during the annual Nijmegen Center for Molecular Life Sciences conference. In that year, she also received the certificate for the best oral presentation during the drug-related research competition from Radboud University Nijmegen. She was thus elected to participate in the national competition and received honorable mention during the Netherlands Federation for Innovative Drug research (FIGON) conference in September 2006. On the 15th of October, 2008, she defended her doctoral thesis entitled “Renal Transport and Drug Interactions of Immunosuppressants” and received the Doctor title in the same date. Since November 2008, she returned to Egypt, to work as a lecturer in the department of Pharmacology and Toxicology, El-Minia University. Her publications include: 1- Nijmegen Center for Molecular Life Sciences Annual Report 2007 Entitled “Understanding Renal Drug-Drug Interactions”. Page 40. 2- Azza A.K. El-Sheikh, Jeroen J.M.W. van den Heuvel, Jan B. Koenderink, and Frans G.M. Russel. Interaction of NSAIDs with MRP2/ABCC2-and MRP4/ABCC4-mediated methotrexate transport. Naunyn-Schmiedebergs Archives of Pharmacology 373: 92, 2006. 3- Azza A.K. El-Sheikh, Jeroen J.M.W. van den Heuvel, Jan B. Koenderink, and Frans G.M. Russel. Interaction of uricosurics and diuretics with the renal urate efflux transporter MRP4/ABCC4. Naunyn-Schmiedebergs Archives of Pharmacology 375: 148, 2007. 4- Azza A.K. El-Sheikh, Jeroen J.M.W. van den Heuvel, Jan B. Koenderink, and Frans G.M. Russel: Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J. Pharmacol. Exp. Ther., 320: 229-35, 2007. 5- Azza A.K. El-Sheikh, Rosalinde Masereeuw and Frans G.M. Russel: Mechanisms of renal anionic drug transport. Eur. J. Pharmacol., 585: 245-255, 2008. 6- Azza A.K. El-Sheikh, Jeroen J.M.W. van den Heuvel, Elmar Krieger, Frans G.M. Russel, and Jan B. Koenderink: Functional role of Arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4). Mol. Pharmacol., 74: 964-971, 2008. 7- Azza A.K. El-Sheikh, Jeroen J.M.W. van den Heuvel, Jan B. Koenderink, and Frans G.M. Russel: Effect of hypouricemic and hyperuricemic drugs on renal urate efflux transporter multidrug resistance protein (MRP) 4. Br. J. Pharmacol., 155: 1066-1075, 2008. 8- Azza A.K. El-Sheikh, Alfons C. Wouterse, Petra H.H. van den Broek, Rosalinde Masereeuw and Frans G.M. Russel: Cyclosporine A inhibits renal mycophenolic acid glucuronidation and multidrug resistance protein 2-mediated excretion. Kidney international, 2010. (submitted). 9- Azza A.K. El-Sheikh, Jeroen J.M.W. van den Heuvel, Jan B. Koenderink, and Frans G.M. Russel. Characterization of human URAT1 in HEK293 Cells and membrane vesicles. (submitted). 10- PhD thesis book entitled: “Renal Transport and Drug Interactions of Immunosuppressants”. The URL link for the thesis is: http://webdoc.ubn.ru.nl/mono/e/el_sheikh_a/renatrand.pdf (ISBN:978-90-9023458-8)