Current concepts of therapeutic landscape combine landscape with principles of holistic health and the interaction of social, affective and material factors. As social tensions widen the gap between the places of emotional retreat and healing from those of everyday sociability, concepts of therapeutic landscape are evolving to reflect society’s current values. This chapter examines how cultural place-based values affect and maintain physical, emotional, mental and spiritual health and well-being in the context of a therapeutic landscape. Five case studies from Australasia, Africa, Middle East and Latin America are analysed to understand better the interrelationships between land, culture and health that make an environment therapeutic. The case studies were selected based on their engagement with the cultural traditions of landscape architecture and how the boundaries of these cultural traditions are negotiated within a modern context. The chapter contributes to the knowledge base of landscape architects and academics interested in the role of culture in producing and maintaining therapeutic landscapes by presenting a cross-cultural analysis to illustrate a range of strategies for incorporating cultural traditions and customs into modern landscape architectural contexts to promote health and well-being.