Health commodity supply chains are vital to a well-functioning health system and advancing national and regional health security goals. This study describes impacts of the COVID-19 pandemic on these chains, learnings from it and the challenges faced by countries. It also provides futuristic strategic recommendations for the building of the supply chain to manage the impacts and guide pandemic responsiveness. We used the PRISMA guideline for systematic review to collate relevant information from both published and unpublished literature. Out of 622 screened records, 38 were included in the review. Major impacts were innovation, collaboration, increased technology, research and development, increased prices and shortage of health products, depletion of supply chain personnel. Challenges were lack of visibility, coordination, resilience and strategy for pandemics, potential substandard medicines epidemic, travel restrictions and inadequate scientific knowledge. The studies recommended increased local production and resilience of supply chains. The pandemic disrupted national and international supply chain systems of medical devices, essential medicines and pharmaceutical products due to border closures, transportation and international trade restrictions. It however exposed hidden potentials in Sub-Saharan Africa. There is need to develop supply chain strategy for emergencies, increase local production and talent pool for supply chain management particularly in Africa.