\r\n\tBook, “Mites, Ticks and Humans", is written by keeping in vision non-availability of any standard text dealing in different aspects of acarology at one place. Separate chapters in this book are devoted to medical importance of mites and ticks; ectoparasites, endoparasites and disease transmitting mites; classification, biology and epidemiology of dust mites; manifestations, diagnostics and preventions of dust mites allergy; ticks transmission of disease causing pathogens; and measures to mitigate mites and ticks. Book will stimulate interest in the readers for more information about different mites and ticks affecting publics. The knowledge contained in the book may prove as best material for graduate and post-graduate level courses, teachers and researchers in entomology, pestss control advisors, professional entomologists, pesticide industry managers, policy planners, and other experts having interest in mites and ticks.
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1. Introduction
Zinc oxide (ZnO) material has been known as a semiconductor for over 70 years, with some of the first literature being reported as early as in 1944 [1]. It was never put to use like other semiconductors (GaN, Si) because it is difficult to dope. The past 19 years have seen a revival on the research and use of material because of new and emerging ways of doping it. The material is naturally n-type [1, 2, 3, 4], and by controlling the conditions of growth, the donor concentration can be controlled. The growth conditions include temperature, diethyl zinc (DEZ) reactant, O2 or H2O reactant, and pressure. P-type material [1, 2, 3, 4] is difficult to grow and tends to slowly revert back to n-type. Researchers [5, 6, 7, 8, 9, 10, 11, 12, 13, 14] who managed to deposit the p-type material have shown that it converts back to n-type within a few days. Maximum time period shown on p-type ZnO was a few months [5, 6, 7, 8, 9, 10, 11, 12, 13, 14].
ZnO is a wide bandgap semiconductor [e.g., (0 K) = (3.441 ± 0.003) eV; (300 K) = (3.365 ± 0.005) eV]. It belongs to the group of IIb-VI compound semiconductors which crystalize exclusively in the hexagonal wurtzite-type structure. The lattice parameters of the wurtzite crystal structure are: a = 3.24 Å and c = 5.21 Å. Related to similar IIb-VI (e.g., CbS, CbSe, ZnSe, and ZnS) or III-V (e.g., AlSb, Bas, GaN, and InSb) semiconductors, it has comparatively strong polar binding and large exciton binding energy of (59.5 ± 0.5) meV. Its density is 5.6 g cm−3, a value which corresponds to 4.2 × 1022 ZnO molecules per cm−3 [1, 2].
ZnO has practical advantages that make it an attractive semiconductor from an industrial point of view. It has low cost; is abundant, nontoxic, and transparent; has large excitonic binding energy of 60 meV; is soluble, compatible with intercellular material; and has wide and direct bandgap of 3.37 eV, making it highly sensitive. It is well known that semiconductors have a small bandgap which allows switching between conduction and off-states. The larger the bandgap, the better the semiconductor is able to switch states and insulate leakage currents. Bandgap affects sensitivity because a device that possesses a wider bandgap allows for higher currents to travel but also prevents leakage currents, which results in more sensitive and accurate readings. With low-temperature fabrication processes, high-quality devices can be fabricated using the conventional processing technology, thereby making it suitable for low-cost mass-production. It has potential applications in optoelectronics, transparent electronics, and spintronics. ZnO and its alloys have versatile electrical and optical properties for applications in thin film or nanowire transistors, light emitters, biosensors, and solar cells. The nanowire biosensor has a high surface-to-volume ratio, enabling real-time and label-free detection [1, 2, 3, 4, 15, 16, 17].
Currently, the main commercial application for ZnO (and/or IGZO) material is in displays, with companies like Sharp and Samsung putting IGZO into mobile phone displays [18, 19, 20]. IGZO displays outperform other semiconductor displays such as amorphous silicon and organic semiconductors by providing improved resolution and reduced power consumption. This is possible because IGZO has a 20× to 50× times higher mobility than amorphous silicon and polymers, which allows for device scaling without affecting performance [18, 19, 20]. Higher mobility values can also be achieved with amorphous silicon technology, but it needs to be laser annealed which is expensive.
2. Growth techniques of ZnO
ZnO films can be grown using three methods: gas transport (vapor phase deposition), hydrothermal synthesis, and/or melt process. Melt growth techniques are a problem due to high vapor pressure of ZnO. Growth using gas transport is difficult to control for large film layers and is normally used for bottom-up ZnO nanostructures. Hydrothermal synthesis is therefore preferred as a method of growth. Thin films can be produced through chemical vapor deposition, metalorganic vapor phase epitaxy, electrodeposition, pulsed laser deposition, sputtering, sol–gel synthesis, atomic layer deposition, spray pyrolysis, etc. All the mentioned techniques fall under hydrothermal synthesis, and one of the preferred methods is atomic layer deposition (ALD). The ALD process is capable of producing highly conformal and quality films [21]. The process is cyclic and is based on the number of reactants. Figure 1 shows that the ALD process for ZnO films is cyclic and depends on two reactants: metallization and oxidation.
Figure 1.
Schematic diagram illustrating a single cycle of ZnO deposition using the ALD tool (A) metallisation and oxidation step, (B) Purge and pump step (C) Cleaning with O2 plasma step, (D) Removing non-used products with Ar step [22].
Metallization uses diethyl zinc (DEZ) as the zinc (Zn) metal precursor. Purge and pump steps are used to separate the execution of the reactants and to remove by-products. Before deposition, the wafer (substrate) is preheated at a temperature that will be used for deposition and it is also cleaned with O2 plasma so as to remove any polymer layer. During the metallization step, the DEZ (Zn (C2H5)2) is absorbed onto the surface of the wafer and the residual Zn (C2H5)2 is removed from chamber. “R” in Figure 1 represents C2H5.Then on another step, water or O2 is delivered to react with the absorbed DEZ [23, 24, 25]. These steps are executed separately, and to ensure this, purge steps are introduced in between the steps.
When water is used instead of O2 for oxidation, the process is called thermal ALD. This process tends to produce films similar to chemical vapor deposition (CVD) techniques [25, 26, 27]. When O2 is used instead of water, then the process needs plasma energy. Remote plasma atomic layer deposition (RPALD) is a fairly new process which is why it is still not in used. It is better than the other deposition techniques as it tends to produce films close to epitaxial layers. The layers are crystalline but tend to be nonuniform to the underlining layer which is why they are not called epitaxial layers. It is a process with great potential for depositing highly conformal and quality films. The process is better than thermal ALD in terms of conformity and quality, but both processes do not generally produce epitaxial layers due to nonuniformity to the underlining substrate. The plasma-assisted ALD method has the following advantages: reduction of OH impurity, allows more freedom in processing conditions, and provides wider range of material properties. The OH impurity is not desired as it affects the conductivity of the semiconductor and induces defects in the dielectrics.
Table 1 compares various growth techniques and how they affect NWFET output characteristics. Chemical vapor deposition (CVD) is the most popular technique for bottom-up nanowire processes. There are two growth techniques classified under CVD which are vapor–liquid–solid (VLS) and vapor–solid (VS) deposition techniques. CVD normally give the highest mobility as they produce crystalline wires with the only flaw being from the catalysts that guide the growth. VS produces better quality nanowires than VLS as it uses no catalysts but instead uses very high temperatures (>900°C). The problem with VS is that it is usually harder to control the size and morphology of the nanowires.
Summary of various methods used for the production of 1-D ZnO nanostructures, adopted from [28].
Table 1 also shows that atomic layer deposition (ALD) is an attractive technique because it deposits high quality films at low temperatures between 120 and 210°C [22, 45]. The problem with ALD is that it has only this window for good quality conducting films. At temperatures below 120°C, the deposition can be incomplete or experience condensation depending on growth rate. At temperatures above 210°C, the deposition tends to experience desorption or it decomposes toward CVD deposition. Nonetheless, it is one of the best techniques toward growing films close to epitaxial growth (crystallinity is achievable whereas uniformity is still difficult to achieve) [22, 45]. The tool has shown potential by achieving high values of field effect mobility >30 cm2/Vs with excellent crystallinity.
2.1 Native point defects
There are three types of defects in a crystal lattice: point defects, area defects, and volume defects. Point defects which are caused by native elements and impurities are the major problem for ZnO semiconductor. Native point defects for ZnO include the following: zinc interstitial (Zni), zinc antisite (Zno), zinc vacancy (VZn), oxygen interstitial (Oi), oxygen antisite (OZn), and oxygen vacancy (Vo). Over the years, a lot of research advocated them as the major cause for the n-type behavior. Oxygen defects are seen as the main contributors toward the n-type behavior [3, 15]. There are some researchers [1, 2, 3, 4] who hypothesize that impurities (not the native point defects) are the main cause of the n-type behavior because they tend to be shallow donors whereas Zn and O2 defects tend to be deep donors [1, 2, 3, 4]. The two theories have not been proven so currently the main cause of the natural n-type behavior of ZnO [1, 2, 3, 4] is not certain.
2.2 Deep donors versus shallow donors: ZnO
ZnO impurities (foreign atoms) are normally incorporated in the crystal structure of the semiconductor. There are two reasons of impurity incorporation: they can either be unintentionally introduced due to lack of control during growth processes or they are intentionally added to increase the number of free carriers in the semiconductor. Impurities in the ZnO should have the ability to be ionized; which is desirable as it increases conductivity. This means that the impurity atoms should be able to give off electrons to the conduction band. If the impurities were acceptors—they should be able to give off holes to the valence band [3, 16].
Donor Impurities for the n-type ZnO can either be shallow or deep. Figure 2 shows shallow donors compared to deep donors. Shallow impurities require little energy to ionize (this is energy typically around the thermal energy or less). These donor impurities possess energy close to the band edge—the extra valence electron of these impurities are loosely bound and occupy effective-mass states near the conduction band maximum- CBM- at low temperatures. Deep impurities on-the-other-hand require energy greater that the thermal energy to ionize. These donor impurities possess energy far from the band edge (CBM) making them very hard to ionize. Their presence within the semiconductor tends to contribute only a small fraction of free carriers. Deep donors are also called traps because they act as effective recombination centers in which electrons and holes fall and annihilate each other. Grain boundaries (GB) are main source of deep state impurities and they adversely affect transistor performance. ZnO is a wide bandgap material and research suggests [3, 4, 16] that there exist possible deep-level traps in GBs. The examples of deep donors are Zn and O ions. Zn acts as a deep donor when there is a vacancy and O acts as a deep donor in any defect state. An example of a shallow donor is the H ion.
Figure 2.
Shallow versus deep donors [1, 2, 3, 4].
2.3 Top-down fabrication of ZnO nanowire FETs
There are four main methods capable of producing nanometer features using top-down approaches: UV stepper lithography, e-beam lithography [46], focused ion-beam lithography [47], and spacer method [45, 48]. UV lithography is the standard industrial method for fabricating nanodevices. E-beam and focused ion-beam lithography are often used and can pattern devices down to 5 nm, but the equipment is very expensive and the pattern writing is very slow. These two instruments resemble scanning electron microscope (SEM) in terms of operation. Whereas SEM is used to focus a beam of electrons to image samples within a chamber, these instruments are used to create patterns on the samples. The difference between e-beam and focused ion-beam is that the latter uses an ion beam to pattern wafers and hence does not require photoresist. Their advantage over optical UV lithography is the small features they reach. For low-cost applications such as biosensors, the problem with these two methods is that they are expensive.
The spacer technique is a low-cost fabrication method for fabricating nanowires. It was first reported in 2005 by Ge et al. [49], and other researchers [44, 50, 51] have since carried it forward. The technique has great potential in shaping nanometer features using conventional, low-cost photolithography. Figure 3 shows the concept of the spacer technique. It uses first anisotropic etch to create a vertical pillar on an insulating layer (SiO2), then after deposition of a semiconductor layer (ZnO) and a second anisotropic etch, to create nanowires made up of the semiconductor layer. This method allows nanowire features with controllable dimensions to be developed. The ICP tool is usually used for anisotropic etching and produces surface roughness <1.5 nm. Other tools such as RIE and ion beam etch produce roughness >5 nm. The fabrication process for the complete ZnO NWFET structure is as outlined in [52].
Figure 3.
Novel spacer technique used to pattern nanowire features. Cross-sectional schematic of nanowire formation (a) before dry etch and (b) after dry etch [22].
3. Background on FETs
The ZnO field-effect transistor (FET) has been around for decades. The success of the device in meeting the technological demands has largely been dominated by the shrinking size of its physical geometry. It has an advantage as a junctionless (no p-n junctions) FET compared to conventional FETs [17, 21, 23, 24, 25, 26, 27, 53, 54]. There has been an introduction of new materials and heterojunction structures developed so as to move away from conventional silicon devices. High-K dielectrics have been introduced to replace the conventional SiO2 which should help maintain acceptable dielectric thicknesses while keeping gate leakage currents low [17, 21, 23, 24, 25, 26, 27, 53, 54].
Even with so many improvements being made to the device, the limits of FET scaling are approaching. The thickness of the oxide (tox) cannot be less than 1 nm due to high tunneling current and significant operational variation. The substrate doping is also very high which creates leakage and tunneling currents that are unacceptable to device operation.
3.1 ZnO thin film transistors (TFTs)
TFTs have also been fabricated using ZnO, mainly as thin film transistors for application in displays. Figure 4 compares 20 ZnO TFTs fabricated by different authors [27, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71] using a variety of fabrication methods over the last 5 years. The graph is a plot of field effect mobility versus subthreshold slope which are two of the main parameters that describe the performance and efficiency of a device. The best device was fabricated by Bayraktaroglu et al. [70] with a SiO2 insulator and pulsed laser-deposited ZnO active channel layer. The device had a field effect mobility 110 cm2/Vs and an excellent subthreshold gate voltage swing of 109 mV/decade. This value of mobility is much higher than the value of around 1 cm2/Vs that is typically achieved with amorphous silicon TFTs in production displays. It is clear therefore that ZnO TFTs have considerable potential for application in high performance displays.
Figure 4.
General literature review on TFTs looking at field effect mobility versus subthreshold slope of as-deposited and doped ZnO films.
3.2 Nanowire field-effect transistors (FETs)
Emerging nonplanar devices [17, 21] are being researched to prolong the future progress for FETs. Devices based on quasi-one-dimensional (1-D) nanostructures are still at an embryonic stage from an industrial point of view. These nanostructures include the following: nanowires, nanobelts, nanoribbons, and nanoneedles [72, 73]. This review is interested in nanowire FETs which are also being researched for application in biosensors because the high surface-to-volume ratio provides high sensitivity.
3.3 Comparing ZnO NWFETs
Figure 5 compares 15 different ZnO NWFETs fabricated by different authors using a variety of methods [22, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86]. The graph is plotted with field effect mobility against the subthreshold slope, which are two important device parameters that determine ZnO NWFET performance. The nanowires were fabricated using top-down and bottom-up (self-assembled) processes. Self-assembled processes tend to display very high field effect mobility which is normally above 200 cm2/Vs; whereas the top-down have lower mobility values. Most of the top-down fabricated devices have mobility <1.0 cm2/Vs with around three papers giving a mobility >10.0 cm2/Vs. The difference in the mobility may be due to the fact that self-assembled nanowires are single-crystal, whereas top-down nanowires are polycrystalline. Nonetheless, top-down techniques are desirable as they currently pave way for mass production and will be pursued in this research investigation.
Figure 5.
Literature review on nanowire FETs looking at field effect mobility versus subthreshold slope of as-deposited and doped ZnO nanowires.
4. Biosensors
A biosensor is defined by the International Union of Pure and Applied Chemistry (IUPAC) as “a self-contained integrated device that is capable of providing specific quantitative or semiquantitative analytical information using a biological recognition element (biochemical receptor), which is retained in contact direct with a transduction element” [87]. A biosensor is a “more-than-Moore device” because it incorporates functionalities that do not necessarily scale according to Moore’s law. Under the roadmap, the device falls under the category of sensors and actuators. Other categories include analogue/RF, passives, HV power, and biochips [88, 89].
Figure 6 shows a typical structure of a biosensor [90, 91, 92]. The biomolecules are contained within an analytic solution and attach themselves to immobilized enzymes or immune-agents on the linkers. Linkers in turn are attached to the transducer. The transducer then converts the charge on the analyte into an electrical signal which is then transmitted for data processing. Biosensors can be considered as part of the research field known as “chemical sensors” in that a biological mechanism is used for analyte detection within an analyte solution [93, 94, 95]. Quasi-one-dimensional nanostructures have a greater surface-to-volume ratio compared to planar structures and are therefore expected to be more sensitive than planar sensors [93, 94, 95].
Figure 6.
Typical structure of a biosensor. The biomolecules are contained within an analytic solution and attach themselves to immobilized enzymes or immune-agents on the receptors. The transducer then converts the energy signal produced into an electrical signal which is then transmitted for data processing. [22].
Nanowires are the same as nanorods. The words can be used interchangeably [80]. These have received enormous attention due to their suitable properties for designing novel nanoscale biosensors. For example, the dimensions of ∼1–100 nm are similar to those of many biological entities, such as nucleic acids, proteins, viruses, and cells [79]. In addition, the high surface-to-volume ratios for nanomaterials allow a large proportion of atoms in the bio-analyte to be located at or close to the surface. Moreover, some nanowire materials have surfaces that can easily be chemically modified which makes them significant candidates for biosensors [79, 80]. There are a number of nanostructure-based electrical biosensors which include single-wall carbon nanotubes (SWCNT), nanowires, nanogaps, nanochannels, and nano-electromechanical (NEM) devices. The project will focus on nanowire-based devices as they have considerable potential for electrical biosensing that offer the possibility of portable assays in a variety of point-of-care environments [48, 90, 96].
4.1 Silicon biosensors
Over the past decade, silicon nanowires have been the most researched for application as biochemical sensors [97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108]. Silicon nanowires are of interest for a number of reasons, for example, the material is well known and is compatible with CMOS integrated circuits for the development of sensor systems [97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108]. The nanowire is expected to have high surface-to-volume ratios which give high sensitivity and the electrical sensing will give real-time label-free detection without the use of expensive optical components. Mass manufacturing is also a main advantage for silicon and is critically important for nanowire biosensor applications because of the widespread uptake of biosensors in “point-of-care” settings, the biosensor needs to be disposable [97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108].
A number of fabrication methods are well established for silicon nanowires which utilize both bottom-up and top-down methods (these methods are called hybrids). It still remains that bottom-up techniques have the advantage of simplicity [97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108]. Bottom-up methods are still limited due to the alignment problem. The hybrid methods require further nanowire technologies to achieve alignment, such as electric field or fluid-flow-assisted nanowire positioning to locate the nanowires between lithographically defined source and drain electrodes. The technique is interpreted as a hybrid between bottom-up and top-down. Top-down methods overcome these problems, and several researchers have used advanced lithography techniques to fabricate single-crystal silicon nanowires on silicon-on-insulator (SOI) substrates. SOI wafers are expensive and to overcome the problem some researchers [109] have devised alternatives to SOI. The electrical output characteristics of silicon nanowires are good and they are well suited for biosensing applications. The sensitivity range for most silicon-nanowire based biosensors is between 50 and 400 mV [97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134].
4.2 Comparing ZnO nanowire biosensors
ZnO is investigated as it is expected to be more sensitive than Si due to its wider bandgap [109]. This is observed by comparing Table 2 with Table 3. ZnO devices show results comparable to silicon devices; especially looking at response time and limit of detection. It is required that biosensors should have the liquid reference electrode. There are many different types of ZnO nanostructures being used for sensing application and Table 2 compares the ZnO nanostructures such as nanotetrapods, nanocombs, and nanorods used for biosensing [110, 121]. Nanotetrapods [123] are like nanorods but with four single crystalline legs. Most of the ZnO devices were synthesized by vapor phase method and then transferred on Au electrode to form a multiterminal network for the sensor receptors. Like all other bottom-up ZnO nanostructures discussed here, they are transferred to a surface of a working electrode to form a thin layer to modify the transducer. The devices have low sensitivity but the nanotetrapods exhibit good detection limit down to ~1.0 nM. The researchers [123] did not explain why the nanostructures possess low sensitivity but its three-dimensional features have the potential for multiterminal communication applications [123].
Summary of characteristics for various 1-D Si biosensors, adopted from [121].
In nanocombs [116] design, each comb has between 3 and 10 rods connected to one another by a single rod. ZnO nanocombs were used as the channel for sensing glucose [116] and as label-free uric acid biosensor based on uricase [124]. The functionalized ZnO nanorods showed thermal stability, anti-interference capability, and direct electron transfer (DET) between enzyme electroactive sites and external electrodes. The activity of the enzyme and the sensitivity can be increased by introducing a lipid film between the channel and the enzyme. Another uric acid biosensor [125] example is based on uricase-functionalized ZnO nanoflakes, which was hydrothermally prepared at low temperatures on Au-coated glass. The sensor produced a sensitivity based on subthreshold slope of ~66 mV/decade. Bottom-up ZnO nanorods [126] were also used as lactate oxidase (LOD) biosensor using glutaraldehyde cross-linkers. The device had a subthreshold sensitivity of ~41 mV/decade, with maximum detection of 0.1 μM. To test for cholesterol, porous ZnO mirco-tubes [127] were constructed using 3-D assembled porous flakes. ZnO nanorods [128] were grown on Ag electrode to make a cholesterol sensor.
5. Conclusion
Most researchers use bottom-up approaches to fabricate the ZnO biosensors because of the straightforward synthesis process. However, these bottom-up devices have variable electrical performance due to the lack of geometrical dimension control and addressing the nanostructures for sensing application. So far, there is limited research reported on top-down ZnO biosensors, and previous work demonstrated the viability of top-down ZnO NWFET for biosensor applications. In the work, however, there was no passivation layer on the ZnO nanowires, which led to the dissolution of the material. This made the device unstable and the sensing results were not reproducible. There exists a need to develop a passivating layer technology and optimize the fabrication process for biosensor applications. That way, a reliable measurement of sensitivity for the nonspecific and specific sensing of lysozyme and bovine serum albumin (BSA) can be achieved.
Acknowledgments
N.M.J. Ditshego would like to acknowledge the Botswana International University of Science and Technology (BIUST) for supporting his doctoral studies and the Southampton Nanofabrication Centre for the experimental work. The author would like to acknowledge the EPSRC EP/K502327/1 grant support.
\n',keywords:"zinc oxide (ZnO), semiconductor device, nanosensor, nanowire field-effect transistor (NWFET), biosensors, growth techniques",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/73514.pdf",chapterXML:"https://mts.intechopen.com/source/xml/73514.xml",downloadPdfUrl:"/chapter/pdf-download/73514",previewPdfUrl:"/chapter/pdf-preview/73514",totalDownloads:469,totalViews:0,totalCrossrefCites:0,dateSubmitted:"June 16th 2020",dateReviewed:"August 24th 2020",datePrePublished:"December 9th 2020",datePublished:"July 14th 2021",dateFinished:"October 8th 2020",readingETA:"0",abstract:"The last 19 years have seen intense research made on zinc oxide (ZnO) material, mainly due to the ability of converting the natural n-type material into p-type. For a long time, the p-type state was impossible to attain and maintain. This chapter focuses on ways of improving the doped ZnO material which acts as a channel for nanowire field-effect transistor (NWFET) and biosensor. The biosensor has specific binding which is called functionalization that is achieved by attaching a variety of compounds on the designated sensing area. Reference electrodes and buffers are used as controllers. Top-down fabrication processes are preferred over bottom-up because they pave way for mass production. Different growth techniques are reviewed and discussed. Strengths and weaknesses of the FET and sensor are also reviewed.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/73514",risUrl:"/chapter/ris/73514",signatures:"Nonofo Mathiba Jack Ditshego",book:{id:"10071",type:"book",title:"Nanowires",subtitle:"Recent Progress",fullTitle:"Nanowires - Recent Progress",slug:"nanowires-recent-progress",publishedDate:"July 14th 2021",bookSignature:"Xihong Peng",coverURL:"https://cdn.intechopen.com/books/images_new/10071.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83962-392-9",printIsbn:"978-1-83962-391-2",pdfIsbn:"978-1-83962-393-6",isAvailableForWebshopOrdering:!0,editors:[{id:"24647",title:"Prof.",name:"Xihong",middleName:null,surname:"Peng",slug:"xihong-peng",fullName:"Xihong Peng"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"324451",title:"Dr.",name:"Nonofo Mathiba Jack",middleName:null,surname:"Ditshego",fullName:"Nonofo Mathiba Jack Ditshego",slug:"nonofo-mathiba-jack-ditshego",email:"ditshegon@biust.ac.bw",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Growth techniques of ZnO",level:"1"},{id:"sec_2_2",title:"2.1 Native point defects",level:"2"},{id:"sec_3_2",title:"2.2 Deep donors versus shallow donors: ZnO",level:"2"},{id:"sec_4_2",title:"2.3 Top-down fabrication of ZnO nanowire FETs",level:"2"},{id:"sec_6",title:"3. Background on FETs",level:"1"},{id:"sec_6_2",title:"3.1 ZnO thin film transistors (TFTs)",level:"2"},{id:"sec_7_2",title:"3.2 Nanowire field-effect transistors (FETs)",level:"2"},{id:"sec_8_2",title:"3.3 Comparing ZnO NWFETs",level:"2"},{id:"sec_10",title:"4. Biosensors",level:"1"},{id:"sec_10_2",title:"4.1 Silicon biosensors",level:"2"},{id:"sec_11_2",title:"4.2 Comparing ZnO nanowire biosensors",level:"2"},{id:"sec_13",title:"5. Conclusion",level:"1"},{id:"sec_14",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'Klingshirn C, Fallert J, Zhou H, Sartor J, Thiele C, Maier-Flaig F, et al. 65 years of ZnO research—old and very recent results. 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Proton radiation hardness of single-nanowire transistors using robust organic gate nanodielectrics. Applied Physics Letters. 2006;89(13):073510'},{id:"B80",body:'Heo Y, Tien L, Kwon Y. Depletion-mode ZnO nanowire field-effect transistor. Applied Physics. 2004;85(12):2274-2276'},{id:"B81",body:'Ng HT, Han J, Yamada T, Nguyen P, Chen YP, Meyyappan M. Single crystal nanowire vertical surround-gate field-effect transistor. Nano Letters. 2004;4(7):1247-1252'},{id:"B82",body:'Park JY, Yun YS, Hong YS, Oh H, Kim JJ, Kim SS. Synthesis, electrical and photoresponse properties of vertically well-aligned and epitaxial ZnO nanorods on GaN-buffered sapphire substrates. Applied Physics Letters. 2005;87(12):1-3'},{id:"B83",body:'Wang W, Xiong HD, Edelstein MD, Gundlach D, Suehle JS, Richter CA, et al. Low frequency noise characterizations of ZnO nanowire field effect transistors. Journal of Applied Physics. 2007;101(4)'},{id:"B84",body:'Kim H, Park J-H, Suh M, Real Ahn J, Ju S. Horizontally aligned ZnO nanowire transistors using patterned graphene thin films. Applied Physics Letters. 2012;100(6):063112'},{id:"B85",body:'Das S, Kim JH, Choi HS, Park YK, Hahn YB. Interfacial and electrical properties of solution processed p-TiO2 in heterojunction devices. Electrochemistry Communications. 2011;13(4):350-354'},{id:"B86",body:'Noriega R, Rivnay J, Goris L, Kälblein D, Klauk H, Kern K, et al. Probing the electrical properties of highly-doped Al:ZnO nanowire ensembles. Journal of Applied Physics. 2010;107(7):074312'},{id:"B87",body:'Thévenot DR, Toth K, Durst RA, Wilson GS. Electrochemical biosensors: Recommended definitions and classification. Biosensors & Bioelectronics. 2001;16(1-2):121-131'},{id:"B88",body:'Roy S, Gao Z. Nanostructure-based electrical biosensors. Nano Today. 2009;4(4):318-334'},{id:"B89",body:'Jung J, Kim SJ, Lee KW, Yoon DH, Kim Y-G, Kwak HY, et al. Approaches to label-free flexible DNA biosensors using low-temperature solution-processed InZnO thin-film transistors. Biosensors & Bioelectronics. 2014;55:99-105'},{id:"B90",body:'Chen K, Li B, Chen Y. Silicon nanowire field-effect transistor-based biosensors for biomedical diagnosis and cellular recording investigation. Nano Today. 2011;6(2):131-154'},{id:"B91",body:'Yano M, Koike K, Ogata KI, Nogami T, Tanabe S, Sasa S. Zinc oxide-based biosensors. Physica Status Solidi (C) Current Topics in Solid State Physics. 2012;9(7):1570-1573'},{id:"B92",body:'Liu J, Goud J, Raj PM, Iyer M, Wang ZL, Tummala RR. Real-time protein detection using ZnO nanowire/thin film bio-sensor integrated with microfluidic system. In: Proceedings—Electronic Components and Technology Conference. 2008. pp. 1317-1322'},{id:"B93",body:'Liu X, Lin P, Yan X, Kang Z, Zhao Y, Lei Y, et al. Enzyme-coated single ZnO nanowire FET biosensor for detection of uric acid. Sensors and Actuators B: Chemical. 2013;176:22-27'},{id:"B94",body:'Mohd Azmi MA, Tehrani Z, Lewis RP, Walker KD, Jones DR, Daniels DR, et al. Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker. Biosensors & Bioelectronics. 2014;52:216-224'},{id:"B95",body:'Shen Y-C, Yang C-H, Chen S-W, Wu S-H, Yang T-L, Huang J-J. IGZO thin film transistor biosensors functionalized with ZnO nanorods and antibodies. Biosensors & Bioelectronics. 2014;54:306-310'},{id:"B96",body:'Choi A, Kim K, Jung H-I, Lee SY. ZnO nanowire biosensors for detection of biomolecular interactions in enhancement mode. Sensors and Actuators B: Chemical. 2010;148(2):577-582'},{id:"B97",body:'Cui Y, Wei Q , Park H, Lieber C. Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. Science (80-). 2001;293(5533):1289-1292'},{id:"B98",body:'Zheng G, Patolsky F, Cui Y, Wang WU, Lieber CM. Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nature Biotechnology. 2005;23(10):1294-1301'},{id:"B99",body:'Lu W, Xie P, Lieber CM. Nanowire transistor performance limits and applications. IEEE Transactions on Electron Devices. 2008;55(11):2859-2876'},{id:"B100",body:'Li Z, Chen Y, Li X, Kamins TI, Nauka K, Williams RS. Sequence-specific label-free DNA sensors based on silicon nanowires. Nano Letters. 2004;4(2):245-247'},{id:"B101",body:'Bunimovich YL, Shin YS, Yeo W-S, Amori M, Kwong G, Heath JR. Quantitative real-time measurements of DNA hybridization with alkylated nonoxidized silicon nanowires in electrolyte solution. Journal of the American Chemical Society. 2006;128(50):16323-16331'},{id:"B102",body:'Dorvel BR, Reddy B, Go J, Duarte Guevara C, Salm E, Alam MA, et al. Silicon nanowires with high-k hafnium oxide dielectrics for sensitive detection of small nucleic acid oligomers. ACS Nano. 2012;6(7):6150-6164'},{id:"B103",body:'Park I, Li Z, Li X, Pisano AP, Williams RS. Towards the silicon nanowire-based sensor for intracellular biochemical detection. Biosensors & Bioelectronics. 2007;22(9-10):2065-2070'},{id:"B104",body:'Tarasov A, Wipf M, Bedner K, Kurz J. True reference nanosensor realized with silicon nanowires, PubMed, Langmuir. May 2012;28(25):9899-9905. DOI: 10.1021/la301555r'},{id:"B105",body:'Zhang G-J, Zhang L, Huang MJ, Luo ZHH, Tay GKI, Lim E-JA, et al. Silicon nanowire biosensor for highly sensitive and rapid detection of dengue virus. Sensors and Actuators B: Chemical. 2010;146(1):138-144'},{id:"B106",body:'Stern E, Klemic J, Routenberg D. Label-free immunodetection with CMOS-compatible semiconducting nanowires. Nature. 2007;445(7127):519-522'},{id:"B107",body:'Lee M-H, Lee K-N, Jung S-W, Kim W-H, Shin K-S, Seong W-K. Quantitative measurements of C-reactive protein using silicon nanowire arrays. International Journal of Nanomedicine. 2008;3(1):117-124'},{id:"B108",body:'Chen S, Bomer JG, van der Wiel WG, Carlen ET, van den Berg A. Top-down fabrication of sub-30 nm monocrystalline silicon nanowires using conventional microfabrication. ACS Nano. 2009;3(11):3485-3492'},{id:"B109",body:'Sun K, Zeimpekis I, Lombardini M, Ditshego NMJ, Pearce SJ, Kiang KS, et al. Three-mask polysilicon thin-film transistor biosensor. IEEE Transactions on Electron Devices. 2014;61(6):2170-2176'},{id:"B110",body:'Zhang Y, Kang Z, Yan X, Liao Q. ZnO nanostructures in enzyme biosensors. Science China Materials. 2015;58(1):60-76'},{id:"B111",body:'Wei A, Sun XW, Wang JX, Lei Y, Cai XP, Li CM, et al. Enzymatic glucose biosensor based on ZnO nanorod array grown by hydrothermal decomposition. Applied Physics Letters. 2006;89(12):123902'},{id:"B112",body:'Yang K, She G-W, Wang H, Ou X-M, Zhang X-H, Lee C-S, et al. ZnO nanotube arrays as biosensors for glucose. Journal of Physical Chemistry C. 2009;113(47):20169-20172'},{id:"B113",body:'Aydoğdu G, Zeybek DK, Pekyardımcı Ş, Kılıç E. A novel amperometric biosensor based on ZnO nanoparticles-modified carbon paste electrode for determination of glucose in human serum. Artificial Cells, Nanomedicine, and Biotechnology. 2013;41(5):332-338'},{id:"B114",body:'Fulati A, Ali SMU, Asif MH, Alvi NH, Willander M, Brännmark C, et al. An intracellular glucose biosensor based on nanoflake ZnO. Sensors and Actuators B: Chemical. 2010;150(2):673-680'},{id:"B115",body:'Yang Z, Zong X, Ye Z, Zhao B, Wang Q , Wang P. The application of complex multiple forklike ZnO nanostructures to rapid and ultrahigh sensitive hydrogen peroxide biosensors. Biomaterials. 2010;31(29):7534-7541'},{id:"B116",body:'Wang JX, Sun XW, Wei A, Lei Y, Cai XP, Li CM, et al. Zinc oxide nanocomb biosensor for glucose detection. Applied Physics Letters. 2006;88(23):233106'},{id:"B117",body:'Liu J, Guo C, Li CM, Li Y, Chi Q , Huang X, et al. Carbon-decorated ZnO nanowire array: A novel platform for direct electrochemistry of enzymes and biosensing applications. Electrochemistry Communications. 2009;11(1):202-205'},{id:"B118",body:'Yang C, Xu C, Wang X. ZnO/Cu nanocomposite: A platform for direct electrochemistry of enzymes and biosensing applications. Langmuir. 2012;28(9):4580-4585'},{id:"B119",body:'Wei Y, Li Y, Liu X, Xian Y, Shi G, Jin L. ZnO nanorods/Au hybrid nanocomposites for glucose biosensor. Biosensors & Bioelectronics. 2010;26(1):275-278'},{id:"B120",body:'Chu X, Zhu X, Dong Y, Chen T, Ye M, Sun W. An amperometric glucose biosensor based on the immobilization of glucose oxidase on the platinum electrode modified with NiO doped ZnO nanorods. Journal of Electroanalytical Chemistry. 2012;676:20-26'},{id:"B121",body:'Curreli M, Zhang R, Ishikawa FN, Chang HK, Cote RJ, Zhou C, et al. Real-time, label-free detection of biological entities using nanowire-based FETs. IEEE Transactions on Nanotechnology. 2008;7(6):651-667'},{id:"B122",body:'Wang WU, Chen C, Lin KH, Fang Y, Lieber CM. Labelfree detection of small-molecule–protein interactions by using nanowire nanosensors. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:3208-3212'},{id:"B123",body:'Lei Y, Yan X, Luo N, Song Y, Zhang Y. ZnO nanotetrapod network as the adsorption layer for the improvement of glucose detection via multiterminal electron-exchange. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2010;361(1-3, 173):169'},{id:"B124",body:'Zhang F, Wang X, Ai S, Sun Z, Wan Q , Zhu Z, et al. Immobilization of uricase on ZnO nanorods for a reagentless uric acid biosensor. Analytica Chimica Acta. 2004;519(2):155-160'},{id:"B125",body:'Ali SMU, Ibupoto ZH, Kashif M, Hashim U, Willander M. A potentiometric indirect uric acid sensor based on ZnO nanoflakes and immobilized uricase. Sensors (Basel). 2012;12(3):2787-2797'},{id:"B126",body:'Jindal K, Tomar M, Gupta V. Inducing electrocatalytic functionality in ZnO thin film by N doping to realize a third generation uric acid biosensor. Biosensors & Bioelectronics. 2014;55:57-65'},{id:"B127",body:'Giri AK, Sinhamahapatra A, Prakash S, Chaudhari J, Shahi VK, Panda AB. Porous ZnO microtubes with excellent cholesterol sensing and catalytic properties. Journal of Materials Chemistry A. 2013;1(3):814-822'},{id:"B128",body:'Ahmad R, Tripathy N, Hahn Y-B. Wide linear-range detecting high sensitivity cholesterol biosensors based on aspect-ratio controlled ZnO nanorods grown on silver electrodes. Sensors and Actuators B: Chemical. 2012;169:382-386'},{id:"B129",body:'Ahmad M, Pan C, Luo Z, Zhu J. A single ZnO nanofiber-based highly sensitive amperometric glucose biosensor. Journal of Physical Chemistry C. 2010;114(20):9308-9313'},{id:"B130",body:'Zhao ZW, Chen XJ, Tay BK, Chen JS, Han ZJ, Khor KA. A novel amperometric biosensor based on ZnO:Co nanoclusters for biosensing glucose. Biosensors & Bioelectronics. 2007;23(1):135-139'},{id:"B131",body:'Shukla SK, Deshpande SR, Shukla SK, Tiwari A. Fabrication of a tunable glucose biosensor based on zinc oxide/chitosan-graft-poly(vinyl alcohol) core-shell nanocomposite. Talanta. 2012;99:283-287'},{id:"B132",body:'Karuppiah C, Palanisamy S, Chen S-M, Veeramani V, Periakaruppan P. Direct electrochemistry of glucose oxidase and sensing glucose using a screen-printed carbon electrode modified with graphite nanosheets and zinc oxide nanoparticles. Microchimica Acta. 2014;181(15-16):1843-1850'},{id:"B133",body:'Wang Y-T, Yu L, Zhu Z-Q , Zhang J, Zhu J-Z, Fan C. Improved enzyme immobilization for enhanced bioelectrocatalytic activity of glucose sensor. Sensors and Actuators B: Chemical. 2009;136(2):332-337'},{id:"B134",body:'Palanisamy S, Cheemalapati S, Chen SM. Enzymatic glucose biosensor based on multiwalled carbon nanotubes-zinc oxide composite. International Journal of Electrochemical Science. 2012;7(9):8394-8407'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Nonofo Mathiba Jack Ditshego",address:"ditshegon@biust.ac.bw",affiliation:'
Electrical, Computer and Telecommunications Engineering Department, CET, Botswana International University of Science and Technology (BIUST), Palapye, Botswana
'}],corrections:null},book:{id:"10071",type:"book",title:"Nanowires",subtitle:"Recent Progress",fullTitle:"Nanowires - Recent Progress",slug:"nanowires-recent-progress",publishedDate:"July 14th 2021",bookSignature:"Xihong Peng",coverURL:"https://cdn.intechopen.com/books/images_new/10071.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83962-392-9",printIsbn:"978-1-83962-391-2",pdfIsbn:"978-1-83962-393-6",isAvailableForWebshopOrdering:!0,editors:[{id:"24647",title:"Prof.",name:"Xihong",middleName:null,surname:"Peng",slug:"xihong-peng",fullName:"Xihong Peng"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"348462",title:"Prof.",name:"Abdelghani",middleName:null,surname:"Chehbouni",email:"epulepuli2001@yahoo.com",fullName:"Abdelghani Chehbouni",slug:"abdelghani-chehbouni",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"2",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"77551",title:"Recent Climate Shocks in the Sahel: A Systematic Review",slug:"recent-climate-shocks-in-the-sahel-a-systematic-review",abstract:"In Africa, the Sahel is increasingly susceptible to climate shocks such as droughts, sandstorms (winds), and floods. Through a systematic review this work tracks the frequency with which these shocks are reported in the literature during the period 1975–2020. This work examines trends to identify which shocks are most reported, documenting their spatial distribution and evaluating the impacts of climatic and non-climatic drivers. In general, 388 shocks were reported in 164 relevant peer review papers. Southern Niger recorded 15.97% of all the shocks while Ethiopia and Senegal recorded 11.85% and 10.85% respectively. Also, West African Sahel saw about 49.97% of all shocks followed by East African Sahel with 29.89% and Central African Sahel with 12.11%. Generally, droughts (n = 219), appear to be the most frequently reported shocks followed by floods (n = 123) and winds (n = 46). The 1975–1985 decade recorded the most shocks (n = 207), followed by the 1997–2007 decade which saw (n = 80) shocks while between 1986 and 1996 a total of 52 shocks were recorded. 52% of the shocks are driven by climatic factors while 47% are driven by non-climatic drivers.",signatures:"Terence Epule Epule, Driss Dhiba and Abdelghani Chehbouni",authors:[{id:"348146",title:"Assistant Prof.",name:"Terence Epule",surname:"Epule",fullName:"Terence Epule Epule",slug:"terence-epule-epule",email:"terence.epule@mail.mcgill.ca"},{id:"348462",title:"Prof.",name:"Abdelghani",surname:"Chehbouni",fullName:"Abdelghani Chehbouni",slug:"abdelghani-chehbouni",email:"epulepuli2001@yahoo.com"},{id:"348463",title:"Prof.",name:"Driss",surname:"Dhiba",fullName:"Driss Dhiba",slug:"driss-dhiba",email:"epulesat@yahoo.com"}],book:{id:"10754",title:"The Nature, Causes, Effects and Mitigation of Climate Change on the Environment",slug:"the-nature-causes-effects-and-mitigation-of-climate-change-on-the-environment",productType:{id:"1",title:"Edited Volume"}}},{id:"79120",title:"Recent Climate Change Adaptation Strategies in the Sahel: A Critical Review",slug:"recent-climate-change-adaptation-strategies-in-the-sahel-a-critical-review",abstract:"Climate change adaptation continues to be central on the agenda of most African countries. Current understanding of the state of adaptation is limited in Africa. The Sahel is selected because of persistent declines in precipitation and rising temperatures. Here, we examine the status of adaptation actions across the Sahel by reviewing the primary peer review literature. A total of 70 peer review papers that document 414 discrete adaptations provide a snapshot of adaptations developed between 1975 and 2020. From a country-to-country perspective, Kenya has the highest number of reported adaptation actions (75 or 18.1%). From a regional standpoint, West Africa recorded about 261 or 18.1% of all adaptation actions reported. Income diversification of livelihoods, and water harnessing were reported as the most used adaptation actions in the Sahel. Based on categories, technically based adaptation actions are the most used options. The period 2008–2016 registered 65.2% of all adaptations. 98% of adaptation actions are reported to be driven by climate while non-climatic drivers account for 95% of adaptation actions. The findings presented here are proxies of climate change adaptation; some relevant information might be found in gray literature which not used because gray literature is less standardized because it is not subject to peer review.",signatures:"Terence Epule Epule, Abdelghani Chehbouni and Driss Dhiba",authors:[{id:"348146",title:"Assistant Prof.",name:"Terence Epule",surname:"Epule",fullName:"Terence Epule Epule",slug:"terence-epule-epule",email:"terence.epule@mail.mcgill.ca"},{id:"348462",title:"Prof.",name:"Abdelghani",surname:"Chehbouni",fullName:"Abdelghani Chehbouni",slug:"abdelghani-chehbouni",email:"epulepuli2001@yahoo.com"},{id:"348463",title:"Prof.",name:"Driss",surname:"Dhiba",fullName:"Driss Dhiba",slug:"driss-dhiba",email:"epulesat@yahoo.com"}],book:{id:"10754",title:"The Nature, Causes, Effects and Mitigation of Climate Change on the Environment",slug:"the-nature-causes-effects-and-mitigation-of-climate-change-on-the-environment",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"347544",title:"Ph.D. Student",name:"Tufa",surname:"Feyissa Negewo",slug:"tufa-feyissa-negewo",fullName:"Tufa Feyissa Negewo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/347544/images/16730_n.png",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Guwahati",institutionURL:null,country:{name:"India"}}},{id:"347546",title:"M.Sc.",name:"Moses",surname:"Sithole",slug:"moses-sithole",fullName:"Moses Sithole",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"348146",title:"Assistant Prof.",name:"Terence Epule",surname:"Epule",slug:"terence-epule-epule",fullName:"Terence Epule Epule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/348146/images/system/348146.jpg",biography:"•\tAssistant Professor of Climate Change Adaptation and Sustainability Strategies in Africa: Mohammed 6 University Polytechnic (UM6P), Ben Guerir, Morocco\nJanuary 2021-ongpoing.\n•\tAssociate Professor of International Food Systems: UnilaSalle, Rouen, France. August 2019-December 2020.\n•\tPost-Doctoral Research Fellow/Lecturer: Department of Geography, McGill University. May 2016-July 30, 2019.\n•\tPost-Doctoral Research Fellow: Département de Géographie, Université de Montréal. May 2014-April 2016. \n•\tResearch and Project Assistant: Ecological modelling and carbon science laboratory (ECO MCS) : Institute des Sciences de l’environnement, Université du Québec à Montréal (UQAM), Montréal. Septembre 2010-April 2014.",institutionString:"Université Mohammed VI Polytechnique",institution:{name:"Université Mohammed VI Polytechnique",institutionURL:null,country:{name:"Morocco"}}},{id:"348198",title:"Prof.",name:"Arup",surname:"Kumar Sarma",slug:"arup-kumar-sarma",fullName:"Arup Kumar Sarma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Guwahati",institutionURL:null,country:{name:"India"}}},{id:"348916",title:"Dr.",name:"Isaac",surname:"Agholor",slug:"isaac-agholor",fullName:"Isaac Agholor",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Mpumalanga",institutionURL:null,country:{name:"South Africa"}}},{id:"349566",title:"M.Sc.",name:"Pawan",surname:"Thapa",slug:"pawan-thapa",fullName:"Pawan Thapa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"351571",title:"B.Sc.",name:"Yonten",surname:"Chophel",slug:"yonten-chophel",fullName:"Yonten Chophel",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"416107",title:"Ph.D. Student",name:"Somala",surname:"Karthik",slug:"somala-karthik",fullName:"Somala Karthik",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"416115",title:"Prof.",name:"M.S.",surname:"Sai Reddy",slug:"m.s.-sai-reddy",fullName:"M.S. Sai Reddy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rajendra Agricultural University",institutionURL:null,country:{name:"India"}}},{id:"416969",title:"Ms.",name:"Gummudala",surname:"Yashaswini",slug:"gummudala-yashaswini",fullName:"Gummudala Yashaswini",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"open-access-statement",title:"Open Access Statement",intro:"
",metaTitle:"Open Access Statement",metaDescription:"Book chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0)",metaKeywords:null,canonicalURL:"/page/open-access-statement/",contentRaw:'[{"type":"htmlEditorComponent","content":"
Based on your preferences and the stage of your scientific projects, you have multiple options for publishing your scientific research with IntechOpen:
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Based on your preferences and the stage of your scientific projects, you have multiple options for publishing your scientific research with IntechOpen:
The Open Access publishing model followed by IntechOpen eliminates subscription charges and pay-per-view fees, thus enabling readers to access research at no cost to themselves. In order to sustain these operations, and keep our publications freely accessible, we levy an Open Access Publishing Fee on all manuscripts accepted for publication to help cover the costs of editorial work and the production of books.
IntechOpen is dedicated to ensuring the long-term preservation and availability of the scholarly research it publishes.
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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
\r\n
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\r\n
\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n
\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
\r\n
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. His research interests include biochemistry, oxidative stress, reactive species, antioxidants, lipid peroxidation, inflammation, reproductive hormones, phenolic compounds, female infertility.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"41",type:"subseries",title:"Water Science",keywords:"Water, Water resources, Freshwater, Hydrological processes, Utilization, Protection",scope:"
\r\n\tWater is not only a crucial substance needed for biological life on Earth, but it is also a basic requirement for the existence and development of the human society. Owing to the importance of water to life on Earth, early researchers conducted numerous studies and analyses on the liquid form of water from the perspectives of chemistry, physics, earth science, and biology, and concluded that Earth is a "water polo". Water covers approximately 71% of Earth's surface. However, 97.2% of this water is seawater, 21.5% is icebergs and glaciers, and only 0.65% is freshwater that can be used directly by humans. As a result, the amount of water reserves available for human consumption is limited. The development, utilization, and protection of freshwater resources has become the focus of water science research for the continued improvement of human livelihoods and society.
\r\n
\r\n\tWater exists as solid, liquid, and gas within Earth’s atmosphere, lithosphere, and biosphere. Liquid water is used for a variety of purposes besides drinking, including power generation, ecology, landscaping, and shipping. Because water is involved in various environmental hydrological processes as well as numerous aspects of the economy and human society, the study of various phenomena in the hydrosphere, the laws governing their occurrence and development, the relationship between the hydrosphere and other spheres of Earth, and the relationship between water and social development, are all part of water science. Knowledge systems for water science are improving continuously. Water science has become a specialized field concerned with the identification of its physical, chemical, and biological properties. In addition, it reveals the laws of water distribution, movement, and circulation, and proposes methods and tools for water development, utilization, planning, management, and protection. Currently, the field of water science covers research related to topics such as hydrology, water resources and water environment. It also includes research on water related issues such as safety, engineering, economy, law, culture, information, and education.
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He has chaired or acted as a technical committee member for twenty-five international forums (conferences). Dr. Shang graduated from Tsinghua University, China, in 2010 with a Ph.D. in Engineering. Prior to that, he worked as a research fellow at Harvard University from 2008 to 2009. Dr. Shang serves as a senior research engineer at the China Institute of Water Resources and Hydropower Research (IWHR) and was awarded as a distinguished researcher at National Taiwan University in 2017.",institutionString:"China Institute of Water Resources and Hydropower Research",institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null,series:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713"},editorialBoard:[{id:"216491",title:"Dr.",name:"Charalampos",middleName:null,surname:"Skoulikaris",slug:"charalampos-skoulikaris",fullName:"Charalampos Skoulikaris",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRMsbQAG/Profile_Picture_2022-04-21T09:31:55.jpg",institutionString:null,institution:{name:"Aristotle University of Thessaloniki",institutionURL:null,country:{name:"Greece"}}},{id:"300124",title:"Prof.",name:"Thomas",middleName:null,surname:"Shahady",slug:"thomas-shahady",fullName:"Thomas Shahady",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002kuIgmQAE/Profile_Picture_2022-03-18T07:32:10.jpg",institutionString:null,institution:{name:"Lynchburg College",institutionURL:null,country:{name:"United States of America"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},publishedBooks:{paginationCount:3,paginationItems:[{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:{title:"Infectious Diseases",id:"6"},selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/348462",hash:"",query:{},params:{id:"348462"},fullPath:"/profiles/348462",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()