The flow of water in rivers is of paramount importance to maintain supply of food and energy requirements to a great extent. The minimum flow in perennial rivers is subjected to groundwater availability, it is further replenished by the water added through precipitation. Climate change not only increases the melting of glaciers and sea level rise, but also influences the surface water flow and quality. As agriculture is directly affected by changing precipitation pattern, the reduction in water resources and untimely addition of water, both act havoc to the food production process. This interconnection makes agriculture even more vulnerable to the scenarios of global warming and climate change. Studies on food-energy-water nexus has opened new avenues of research in sustainable water management. The role of sustainable flow of water in rivers is highlighted which needs to be understood in era of climate change.