Differential diagnosis of neurodevelopmental disorders (Asperger’s syndrome).
\r\n\tNot all mixtures of particles and liquids can be considered slurries. A slurry has its character quite different from the carrying liquid (sometimes referred to as the vehicle). A Newtonian liquid has its shear stress directly proportional to its rate of deformation, but this is seldom the case for a slurry. In general, slurries are referred to as non-Newtonian liquids and ways of dealing with them are important threads in this text.
\r\n\r\n\tPipe blockages and pipe wear cause high costs to industry, in both maintenance and loss of production. This waste, and environmental damage which comes with it, can be shown to be reduced by careful application of slurry technology. This book will welcome recent research efforts to understand slurries related to the above-mentioned topics.
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Cabanelas",slug:"juan-c.-cabanelas"}]},{id:"36179",title:"Use of FTIR Analysis to Control the Self-Healing Functionality of Epoxy Resins",slug:"use-of-ft-ir-analysis-to-control-the-self-healing-functionality-of-epoxy-resins",signatures:"Liberata Guadagno and Marialuigia Raimondo",authors:[{id:"106836",title:"Prof.",name:"Liberata",middleName:null,surname:"Guadagno",fullName:"Liberata Guadagno",slug:"liberata-guadagno"}]},{id:"36180",title:"Infrared Analysis of Electrostatic Layer-By-Layer Polymer Membranes Having Characteristics of Heavy Metal Ion Desalination",slug:"infrared-analysis-of-electrostatic-layer-by-layer-polymer-membranes-having-characteristics-of-heavy",signatures:"Weimin Zhou, Huitan Fu and Takaomi Kobayashi",authors:[{id:"110384",title:"Dr.",name:"Takaomi",middleName:null,surname:"Kobayashi",fullName:"Takaomi Kobayashi",slug:"takaomi-kobayashi"}]},{id:"36181",title:"Infrared Spectroscopy as a Tool to Monitor Radiation Curing",slug:"infrared-spectroscopy-as-a-tool-to-monitor-radiation-curing",signatures:"Marco Sangermano, Patrick Meier and Spiros Tzavalas",authors:[{id:"112286",title:"Dr.",name:"Spiros",middleName:null,surname:"Tzavalas",fullName:"Spiros Tzavalas",slug:"spiros-tzavalas"},{id:"114382",title:"Prof.",name:"Marco",middleName:null,surname:"Sangermano",fullName:"Marco Sangermano",slug:"marco-sangermano"},{id:"114384",title:"Dr",name:"Patrick",middleName:null,surname:"Meier",fullName:"Patrick Meier",slug:"patrick-meier"}]},{id:"36182",title:"Characterization of Compositional Gradient Structure of Polymeric Materials by FTIR Technology",slug:"characterization-of-compositional-gradient-structure-of-polymeric-materials-by-ft-ir-technology",signatures:"Alata Hexig and Bayar Hexig",authors:[{id:"20867",title:"Dr.",name:"Bayar",middleName:null,surname:"Hexig",fullName:"Bayar Hexig",slug:"bayar-hexig"},{id:"111986",title:"Dr.",name:"Alata",middleName:null,surname:"Hexig",fullName:"Alata Hexig",slug:"alata-hexig"}]},{id:"36183",title:"Fourier Transform Infrared Spectroscopy - Useful Analytical Tool for Non-Destructive Analysis",slug:"fourier-trasform-infrared-spectroscopy-useful-analytical-tool-for-non-destructive-analysis",signatures:"Simona-Carmen Litescu, Eugenia D. 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García Casillas, Claudia A. Rodriguez Gonzalez and Carlos A. Martínez Pérez",authors:[{id:"104636",title:"Dr.",name:"Perla E.",middleName:null,surname:"García Casillas",fullName:"Perla E. García Casillas",slug:"perla-e.-garcia-casillas"},{id:"112440",title:"Dr.",name:"Carlos A.",middleName:null,surname:"Martínez Pérez",fullName:"Carlos A. Martínez Pérez",slug:"carlos-a.-martinez-perez"},{id:"112441",title:"Dr.",name:"Claudia A.",middleName:null,surname:"Rodriguez Gonzalez",fullName:"Claudia A. Rodriguez Gonzalez",slug:"claudia-a.-rodriguez-gonzalez"}]},{id:"36187",title:"Determination of Adsorption Characteristics of Volatile Organic Compounds Using Gas Phase FTIR Spectroscopy Flow Analysis",slug:"determination-of-adsorption-characteristics-of-volatile-organic-compounds-using-gas-phase-ftir-spect",signatures:"Tarik Chafik",authors:[{id:"107310",title:"Prof.",name:"Tarik",middleName:null,surname:"Chafik",fullName:"Tarik Chafik",slug:"tarik-chafik"}]},{id:"36188",title:"Identification of Rocket Motor Characteristics from Infrared Emission Spectra",slug:"identification-of-rocket-motor-characteristics-from-infrared-emission-spectra",signatures:"N. Hamp, J.H. Knoetze, C. Aldrich and C. Marais",authors:[{id:"112229",title:"Prof.",name:"Chris",middleName:null,surname:"Aldrich",fullName:"Chris Aldrich",slug:"chris-aldrich"},{id:"112232",title:"Prof.",name:"Hansie",middleName:null,surname:"Knoetze",fullName:"Hansie Knoetze",slug:"hansie-knoetze"},{id:"135327",title:"Ms.",name:"Corne",middleName:null,surname:"Marais",fullName:"Corne Marais",slug:"corne-marais"}]},{id:"36189",title:"Optical Technologies for Determination of Pesticide Residue",slug:"optical-technology-for-determination-of-pesticide-residue",signatures:"Yankun Peng, Yongyu Li and Jingjing Chen",authors:[{id:"113343",title:"Prof.",name:"Yankun",middleName:null,surname:"Peng",fullName:"Yankun Peng",slug:"yankun-peng"},{id:"116636",title:"Dr.",name:"Yongyu",middleName:null,surname:"Li",fullName:"Yongyu Li",slug:"yongyu-li"},{id:"116637",title:"Dr.",name:"Jingjing",middleName:null,surname:"Chen",fullName:"Jingjing Chen",slug:"jingjing-chen"}]},{id:"36190",title:"High Resolution Far Infrared Spectra of the Semiconductor Alloys Obtained Using the Synchrotron Radiation as Source",slug:"high-resolution-spectra-of-semiconductor-s-alloys-obtained-using-the-far-infrared-synchrotron-radi",signatures:"E.M. Sheregii",authors:[{id:"102655",title:"Prof.",name:"Eugen",middleName:null,surname:"Sheregii",fullName:"Eugen Sheregii",slug:"eugen-sheregii"}]},{id:"36191",title:"Effective Reaction Monitoring of Intermediates by ATR-IR Spectroscopy Utilizing Fibre Optic Probes",slug:"effective-reaction-monitoring-of-intermediates-by-atr-ir-spectroscopy-utilizing-fibre-optic-probes",signatures:"Daniel Lumpi and Christian Braunshier",authors:[{id:"109019",title:"Dr.",name:"Christian",middleName:null,surname:"Braunshier",fullName:"Christian Braunshier",slug:"christian-braunshier"},{id:"111798",title:"MSc.",name:"Daniel",middleName:null,surname:"Lumpi",fullName:"Daniel Lumpi",slug:"daniel-lumpi"}]}]}],publishedBooks:[{type:"book",id:"1677",title:"Current Topics in Phylogenetics and Phylogeography of Terrestrial and Aquatic Systems",subtitle:null,isOpenForSubmission:!1,hash:"3957889711812e3a7e359246daf57be1",slug:"current-topics-in-phylogenetics-and-phylogeography-of-terrestrial-and-aquatic-systems",bookSignature:"Kesara Anamthawat-Jónsson",coverURL:"https://cdn.intechopen.com/books/images_new/1677.jpg",editedByType:"Edited by",editors:[{id:"101215",title:"Prof.",name:"Kesara",surname:"Anamthawat-Jónsson",slug:"kesara-anamthawat-jonsson",fullName:"Kesara Anamthawat-Jónsson"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9682",title:"Prunus",subtitle:null,isOpenForSubmission:!1,hash:"48dbcfc917e1632fcde9eb4b9f4f1fd7",slug:"prunus",bookSignature:"Ayzin Küden and Ali",coverURL:"https://cdn.intechopen.com/books/images_new/9682.jpg",editedByType:"Edited by",editors:[{id:"200365",title:"Prof.",name:"Ayzin B.",surname:"Küden",slug:"ayzin-b.-kuden",fullName:"Ayzin B. 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One of the tragedies of the twentieth century, more particularly in child and adolescent psychiatry, is the tradition of blaming families and particularly mothers for psychiatric problems. Tragically, we had “schizophrenogenic mothers” as “causes” of schizophrenia and “refrigerated mothers” as “causes” of autism. Even more recently, tragically, John Bowlby [1], in discussing “causal factors” in relation to autism, mentioned “inappropriate mothering”. This is another mother-blaming idea. The current understanding of these disorders, intellectual disability, ADHD, autism, Asperger’s syndrome, tics, etc., is a neurodevelopmental disorder with schizophrenia and bipolar disorder also being neurodevelopmental, and all have significant neurobiological inputs. Some personality disorders should also be considered as being on the neurodevelopmental spectrum. The neurodevelopmental trajectory will include the addition of more neurodevelopmental disorders, e.g., bipolar, schizophrenia and depression as the person gets older.
\nAll diagnoses of autism have to take a developmental history from childhood, which will include persistent deficits in social communication and social interaction from the early developmental period, as well as restricted, repetitive patterns of behaviour causing clinically significant impairment in functioning (American Psychiatric Association [2]). The problem with adult autism diagnosis will include getting a relatively early history from an informant which may be a parent or other, the problem of camouflaging because of treatment or just life experience which makes it more difficult to diagnose the adult with autism. They may have learned about eye contact, etc. School reports or home videos sometimes help. They will often present with comorbidities, for example, depression, (70%), anxiety (40%), attention deficit disorder or psychosis. Mazefsky and White [3] “caution against excessive reliance on ADOS (Autism Diagnostic Observation Scale), Lord et al. [4] for diagnosis”.
\nSchizophrenia and bipolar disorder are now seen as neurodevelopmental disorders with a widening of the neurodevelopmental spectrum.
\nEvans [5] states that the diagnosis of “schizophrenia, psychosis and autism in children, were largely interchangeable during the 1940s and 1950s” [6]. They were described as separate by Kolvin et al. [7]. This view was not supported [8].
\nAccording to Scull [9], Steven Hyman, the former director of NIMH stated that DSM 5 “was totally wrong in the way it’s authors could not have imagined. So in fact, what they produced was an absolute scientific nightmare. Many people who got one diagnosis got five diagnoses, but they did not have five diseases—they have one underlying condition”. Thomas Insel [9], who was also the director of the NIMH stated that DSM 5 showed “a lack of validity … as long as the research community takes DSM 5 to be a bible, we will never make progress. People think that everything has to match DSM 5 criteria, but what you know … biology never the book, and he went on to point out that in future the NIMH would be, “re-orientating into research away from DSM 5 categories … patients with mental illness deserve better”. Indeed, the NIMHS, under their director, Insel, gave up on this and aimed at a transdiagnostic study of psychiatric problems, and further studies should be based on biomarkers, neuroimaging and laboratory tests. This is a good aspiration and research efforts are being made in that direction. Clearly, Hyman and Insel were absolutely correct. He [9] proposed Research Domain Criteria to collect “genomic, cellular, imaging, social and behavioural information”, and he also recommended focusing on the brain and “connectopathies”. Thomas Insel noted that psychiatrists “actually believe, (that their diagnoses) are real, but there’s no reality. They are just constructs”. The first step is to analyse the huge spectrum of empathy and diagnosis.
\nRutter [10] states that “the concept of autism as a variety of schizophrenia is very probably wrong”. The real answer is that they overlap and are not watertight categories. Rutter [11] stated that “infantile autism is not anything to do with schizophrenia, is not primarily a disorder of social relationship”. This is incorrect because they do overlap and autism is primarily a disorder of social relationships. Sullivan et al. [8] point out that “ASD, schizophrenia and bipolar disorder share common aetiological factors”. This would be supported by Abel [12] who points out that “it has been suggested that, (as for common genetic variants), many of the candidate genes identified may not be coding for schizophrenia per se, but for a broader construct such as psychosis, or neurocognitive deficits which occur in schizophrenia and other conditions”. Rapaport et al. [13] states that many individually rare genetic abnormalities affect common pathways containing hundreds of genes that affect neuronal development and regulation. Carroll et al. [14] point out that some of the specific genetic loci implicated encode proteins, such as neurexins and neuroligins, which function in synaptic development and plasticity and therefore represent a common biological pathway for disorders. Fatemi [15] points out the pathological involvement of Reelin gene or its protein product in autism and schizophrenia. Reelin is a glycoprotein that helps guide brain development in an orderly fashion [15]. Fatemi [15] notes that Reelin deficits may cause abnormal corticogenesis and alter synaptic plasticity. In addition, Burbach et al. [16] note that contact in associated protein affects receptor/signalling units and are thought to mediate neuron-glial cell interactions, neuron migration and dendritic orientation. Contactin is a member of the neurexin family, and there are deletions and disruptions in neurexin 1 in autism and schizophrenia.
\nRutter [17] points out that “adult schizophrenia is rare in both parents and brothers and sisters of autistic children”. This is incorrect. Stone et al. [18] pointed out that there’s evidence that parental diagnosis of schizophrenia was associated with elevated rates of autism offspring. Rapaport et al. [13] points out that familial schizophrenia like psychosis is a risk factor for “narrowly defined autism”.
\nBoth autism and schizophrenia can show formal thought disorder with poverty of content, illogical and loose associations. Solomon et al. [19] pointed out that when patients with first episode psychosis were compared to patients with ASD, they showed problems with semantics, syntax and coherence, although these deficits are more severe in ASD. They also noted that social interactional deficits are part of both conditions. Both have theory of mind deficits and problems with eye to eye gaze. In addition, they both have problems reading emotions from faces. Chris Frith [20] points out that “social withdrawal, stereotyped behaviour, and lack of communication are all typical features of childhood autism and chronic ‘negative’ schizophrenia”. He emphasised mentalisation deficits in schizophrenia, which also occur in autism. In fact, they both show a disturbed sense of self. In comparison with schizophrenia, persons with autism show greater problems in reading faces, greater poverty of speech, as well as content and more perseveration of language, including echolalia and pronominal reversal, and more problems with set shifting and preservation of sameness. In comparison with autism, persons with schizophrenia show greater illogicality of thought, show more positive symptoms of psychosis, have mostly later onset (different from autism), run a more elapsing remitting course, show less stereotyped and repetitive behaviour, show less resistance to change, show less challenging behaviour as on an in-patient ward and show more jumping to conclusions.
\nCraddock and Owen [21] discuss a gradient of neurodevelopmental psychopathology from mental retardation to autism to schizophrenia to schizoaffective disorder to bipolar disorder. Nevertheless, the developmental process underlying these similar end points in autism and schizophrenia may be very different. Sporn et al. [22] suggest that “autistic behaviour may be a non-specific response to a variety of early developmental insults, and thus pre-morbid PDD (Pervasive Developmental Disorder) features in early onset schizophrenia may be an exaggeration of neurodevelopmental abnormalities seen in adult schizophrenia” and that “autism may reflect a separate additive risk factor for schizophrenia with very early onset”. Certainly, psychotic risk factors are very similar to autistic symptoms, as is the case with schizotaxia, schizotypal personality disorder and schizoid personality disorder.
\nRutter [23] states that delusions and hallucinations “are quite rare in autistic children, even when they reach adolescence and early adult life”. This has not been my clinical experience, having diagnosed about 5000 children and adults and currently being involved with over 100 persons with autism in in-patient and out-patient settings.
\nSimple schizophrenia Kolb [24] is simply autism spectrum disorder. In my view, the so-called simple schizophrenia involves a disturbance of emotion, disturbance of interest, disturbance of activity, impoverishment of personality, shallowness of emotions and eccentricities. This would be classical high-functioning autism or what was called Asperger’s syndrome in former classifications ICD 10 [25]. This is currently being updated.
\nKanner [26] was correct when he pointed out that “the extreme isolation from people … infantile autism bears so close a resemblance to schizophrenic withdrawal that the relationship between the two conditions deserves serious consideration”. Of course other times, he described them as very separate. Asperger [27] pointed out that “the schizophrenic patient seems to show progressive loss of contact, the children we diagnose (now called Asperger’s syndrome), lack contact from the start”. The problem here is that some of the patients with autism do follow this pattern, but others have regressive autism, where they develop normally and then regress with loss of language, etc. I’ve seen this occurring up to 3 or 4 years of age.
\nRutter [11] states that “the social class of parents of autistic children is most unlike that of the parents of schizophrenics. A high proportion of the parents of autistic children are of above average intelligence and superior socio-economic states”. This is incorrect, as shown by Gillberg and Schumann [28]. In my clinical practice, I constantly see patients from every social class with autism and observe schizophrenia, bipolar disorder, etc. in their family histories.
\nUsing narrow criteria of autism ADI-R, etc., Baird et al. [29] found a prevalence of 25 per 10,000, but when the broader autism spectrum criterium was used, a prevalence of 116 per 10,000 was found. This unfortunately means that over three quarters of the persons with autism in the community have what I would call “real” autism or clinical autism (autism spectrum disorder) and were missed by these narrow-based instruments. Currently, the prevalence of autism is 1/59 CDC and 1/37 males [30].
\n\nSee Table 1 attached.
\nAsperger syndrome (DSM-IV) diagnostic criteria | \nImpairment in use of eye-to-eye gaze, facial expression, body postures | \nFailure to develop peer relationships to developmental level | \nLack of spontaneous seeking to share enjoyment | \nLack of social and emotional reciprocity | \npre-occupation with one or more stereotyped pattern of interest | \nInflexible adherence to specific non-functional routines or rituals | \nStereotyped and repetitive motor mannerisms | \nPersistent pre-occupation with parts of objects | \nClinically significant impairment in social or occupational functioning | \nNo clinically significant delay in language development | \nNo clinically significant delay in cognitive development or self-help skills | \n
---|---|---|---|---|---|---|---|---|---|---|---|
Schizoid personality in childhood | \n\n | Yes | \nYes | \nYes | \nYes | \nYes | \n\n | \n | Yes | \nYes | \nYes | \n
Obsessive compulsive personality disorder | \n\n | \n | Yes, often | \nYes, often | \nYes | \nYes | \n\n | \n | Yes | \nYes | \nYes | \n
Schizotypal disorder | \n\n | Yes | \nYes | \nYes | \nYes, sometimes | \n\n | \n | \n | Yes | \nYes | \nYes | \n
Avoidant personality disorder | \nYes | \nYes | \nYes | \nYes | \n\n | Yes | \n\n | \n | Yes | \nYes | \nYes | \n
Differential diagnosis of neurodevelopmental disorders (Asperger’s syndrome).
Canitano et al. [31] showed that 22% of ASDs presented with tic disorder, but there was a “difficulty in discriminating complex tics and OCD symptoms, and ASD symptoms”. Nevertheless, the overlap between neurodevelopmental disorders is consistent. This equates with clinical experience and clinical reality. Maybe we need a subcategory called ASD plus tics and another category ASD without tics, another category with tics with ADHD and another category tics without ADHD, tics without OCD, etc. Stein [32] notes the overlap between autism, tics and stereotypic movement disorder. There is considerable neurobiological data in relation to OCD spectrum disorder. Stein [32] again emphasises the “possibly overlapping phenomenological and neurobiological features”. Stein [32] points out that “there is increasing evidence that a sub-set of OCD may be genetically related to Tourette’s Disorder, manifests with tics or OCD and involving both the serotonin or dopamine systems and the basal ganglia”. Meir et al. [33] showed that “individuals diagnosed with OCD displayed a nearly four-fold higher risk to be diagnosed with ASD in later life” and that “the high co-morbidity sequential risk and shared familial risks between OCD and ASD’s are suggestive of partially shared etiological mechanism”. It would appear then that some neurosis (OCD) could be neurodevelopmental in origin, at least partly. This again shows the lack of sharp delineation between psychiatric diagnoses.
\nThere is a very high comorbidity between autism and ADHD. Child psychiatric disorders have a comorbidity more than expected by chance [34]. Attention and hyperactivity are common in many disorders and, indeed, many more disorders in child psychiatry, and there is clearly poor separation of condition at a clinical level. Measurement issues are common. In relation to comorbidity, there are shared risks factors and one disorder creating an increased risk for another disorder. Neil et al. [35] pointed out that there are correlated liabilities where the risk factors of the two disorders correlate. There are social deficits in both ADHD and autism with overlap from an etiological point of view, but with ADHD the social deficits are more impulsive, and with autism, the social deficits can again be impulsive, but also, they can be due to lack of social know-how and theory of mind deficits. There is no sharp division here.
\nIn a study of ADHD combined type, with one or more siblings, the diagnosis of autism was excluded at the beginning, and siblings with ADHD were compared with siblings without ADHD by Mulligan et al. [36]. They wrote that phenotypic correlation of ADHD and autism symptoms was 0.71 and that 32% of this correlation was due to shared familial characteristics but with a higher percentage for male ADHD probands. There was a trend for children with high ADHD symptoms to have high autism symptoms, as measured by the Social Communication Questionnaire. ADHD probands with definite language disorder or motor disorder had significantly higher symptoms of autism than those without. This study showed that autism symptoms as part of the ADHD phenotype were partly true. These were familial. Probands with autistic traits tend to have siblings with autistic traits, and probands without autistic traits tend to have affected siblings without autistic traits. Finally, latent class analysis of SCQ symptoms in probands with ADHD combined type showed the following clusters of autism symptoms: 31% with few or no symptoms of autism, 22.5% with repetitive and stereotyped behaviour, 21% with communication domain symptoms, 18.5% communication and reciprocal interaction domains and 7% who had symptoms in all three domains.
\nThe percentage of phenotypic correlation due to shared familial influences (autistic symptoms and ADHD) was 35% for the whole group and 62% for males and 12% for females. In a family with a male child with ADHD and comorbid autistic symptoms, a second child with ADHD is also likely to have comorbid autistic symptoms (not so female), which suggest a different aetiology according to sex. Gillberg’s [37] disorder of attention, motor control and perception would be showing similar findings. Fifty percent of children with DAMP had autistic features.
\nChildren with oppositional defiant disorder and conduct disorder have more autistic traits than children without these comorbid disorders and ADHD [38]. Children with ADHD have more subthreshold symptoms of autism. Children with combined ADHD and social communication deficits are at increased risk of motor and language disorders. Overall, this shows the massive heterogeneity that is evident in child psychiatry classifications, and clearly, ADHD is not a homogenous disorder. Forty two percent of children with ADHD had few symptoms of autism. That autism symptoms are part of the ADHD phenotype is partly true. Autistic traits in ADHD are familial. This again supports the lack of a sharp overlap between neurodevelopmental disorders, here, autism and ADHD.
\nIf I was to plan an assessment programme in child psychiatry again from the start, I would assess the following dimensions: social reciprocity, pragmatic language, oppositionality, working memory, delinquency, attention, impulsivity, activity, capacity to read non-verbal behaviour, preservation of sameness and fixations.
\nThis would be a transdiagnostic approach.
\nA not insignificant number of personality disorders are developmental disorders. This will require further research. One example is schizoid personality disorder. Another is paranoid personality disorder and, another, borderline personality disorder. Obsessive compulsive personality disorder could be also included in this group. There’s quite a good case for narcissistic personality disorder to be included. An older term, anankastic personality disorder [39], could also be included. Many individuals with psychopathy have a developmental disorder, and a group of these have been called criminal autistic psychopathy [40]. There is a clear overlap between psychopathy and autism spectrum disorders. This is despite some research showing that persons with psychopathy have good theory of mind skills, while persons with autism don’t. Nevertheless, more recent research has shown that particularly persons with high IQ can have good theory of mind skills while, at the same time, having autism.
\nBlair [41] stated that “cognitive empathy or theory of mind is intact in individuals with psychopathy”. These ideas have been very seriously undermined by Drayton et al. [42] in relation to automatic perspective taking. Previous research did not take the complexity of cognitive empathy into account, and this led to serious misunderstandings of cognitive empathy. Drayton et al. [42] point out that “automatic theory of mind processes are engaged when an individual unintentionally represents the perspective of another person,” also called “altercentric interference”. Drayton et al. [42] suggest that “psychopathic individuals have a diminished propensity to automatically think from another’s perspective, which may be the cognitive root of their deficits in social functioning and moral behaviour”. Drayton et al. [42] raise, for this author, the possible failure of previous research on theory of mind and psychopathy, failing “to tap into a critical component of normal theory of mind processing; or tendency to take other’s perspective automatically”. Drayton et al. [42] defined “automatic theory of mind processes” as an individual representing “the thoughts and feelings of another person without intending to do so”. They also point out that psychopathic individuals have a previously unobserved cognitive deficit that might explain their patterns of destructive and anti-social behaviour, that is, … failure “to automatically take the perspective of others, but can deliberately (controlled), take the perspective of others”. These findings suggest that psychopathic individuals have the ability to take the perspective of others but lack the propensity to do so. It seems they can pass theory of mind tasks in the research situation but fail to do so in the real world situation. This is one of the endless problems of laboratory research not translating into the “real world,” that is, the clinical world. This lack of generalisation can be a serious flaw in academic psychological research. Drayton et al. [42] note that “psychopathic individuals do show deficits in their ability to understand what others are feeling but this capacity to represent other feelings appears to be distinct from capacity to represent what others see and believe”. They also point out that “psychopathic individuals appear to represent other’s perspective in a relatively typical manner when doing so. It is goal-conducive and yet is able to ignore other’s perspective when it is not conducive”. This means that all previous theory of mind research on psychopathy missed the fundamental point of the deficit of automatic perspective of others. Drayton et al. [42] point out that “this combination of relatively intact deliberative Theory of Mind but impaired spontaneous theory of mind may allow psychopathic individuals to use information about others’ mental states to achieve their own ends, while at the same avoid the, ‘cost,’ of automatically representing other’s mental states, resulting in callous and chronic criminal behaviour”. They have no empathic interest in other minds, except getting their own egocentric desires met.
\nIn relation to psychiatry, there’s a sharp difference between findings in university laboratories and the findings in clinical practice. Research groups are very rarefied and very often do not represent what is found in the general population, clinically. An example is autism defined by the Autism Diagnostic Interview or Autism Diagnostic Observational Scale which give you a very narrow definition of autism, very unlike what you find in the general population which is the broader autism phenotype [43].
\nAsperger originally defined persons with autism as being autistic psychopaths, which Frith [44] described as autistic psychopathy or autistic personality disorder. In actual fact, there is a lot of truth in Asperger’s [27] definition of autistic psychopaths. This has been brought back now with the terms criminal autistic psychopathy [40, 45]. Indeed, the following could be seen as synonyms, autistic psychopathy, autistic personality disorder, high-functioning autism and Asperger’s syndrome.
\nThe kind of criminality seen in autism (criminal autistic psychopathy) would include arson, stalking, sex offences and strange repetitive crimes. According to the Centers for Disease Control [30], developmental disorders are characterised by problems with language, mobility, self-help and independent living. There is a myth that ASD and personality disorder and psychopathy are completely different. There is also a myth that autism and Asperger’s syndrome have little or no relationship with criminality and serious murder. Patricia Howlin [46] stated “little, if any significant association between autism and criminal offending”. This is clearly not supported by my reading of the literature [40]. Sipponma [47] pointed out that 27% of adult offenders in her study met criteria for autism spectrum disorder. These could be called criminal autistic psychopathy. Ashead and Sarkar [48] described correctly personality disorders as “developmental in nature”, and they noted that personality regulates social relationships, arousal impulsivity and emotions, as well as self-directedness and self-soothing as well as verbal and non-verbal communication problems. What is of interest is that all of these areas are abnormal in ASD and personality disorder.
\nAshead and Sarkar [48] note the following clusters of personality disorders: odd, eccentric behaviour; anti-social, borderline and narcissistic personality disorders; fearful and anxious behaviour; and avoidant, dependent and obsessive compulsive.
\nAll these clusters, clearly at a descriptive level, overlap with ASD. Ashead and Sarkar [48] describe the following features of personality disorder:
Emotional indifference
Anger, suspicion and fearfulness
Fears of others attacking and threatening them
Brief psychotic episodes
Odd beliefs
Magical thinking
Preoccupation and ruminations
Identity confusion
Empathy problems
Major problems in in-patient units
Failure to confirm to social norms
Social relationship problems
Social reciprocity problems
Impulsivity
Irrationality
Disregard for safety of self and others
Reduced reaction to upset in other people
Preoccupation with one or more stereotyped patterns of behaviour
Problems with emotional processing
Emotional detection problems
Reduced observing self
Reduced self-awareness and capacity to decentre the self
Egocentricity
Low affiliation and harm avoidance
All of these features also occur in autism spectrum disorders. Of course, in a way, this is not surprising since the boundaries between most psychiatric disorders are fluid and we do not have an accurate, categorical diagnosis at this point in time, assuming we ever will.
\nIt’s interesting that Wolfe [49], in her group of schizoid disorder overlapping with Asperger’s syndrome, found “fraudulent behaviour and pathological lying”; in that, 5 out of 13 had “falsely reported their parents of being cruel to them” and “had used aliases”.
\nThere is a myth that persons with high-functioning autism cannot lie. This is utterly false, as from a clinical perspective, many parents complain to me about their children with high-functioning autism being what they call “inveterate liars”. Of course, the great majority of persons with autism are the opposite and are incredibly honest, open, moral, etc. These features of autism spectrum disorder occur in the general population, as do features of personality disorder. It’s only when you get to a certain threshold that you would get a diagnosis of autism or personality disorder. In truth, we need a new classification system in psychiatry again. The problem is that most of our current disorders overlap and are therefore not independent. We need to go back from a classificatory point of view, to a pre-Kraepelin period and, in a way, that is, what the NIMH is stating with their transdiagnostic research.
\nThere are a number of phrases associated with personality disorder, which could also be associated with autism spectrum disorder:
Schizoid personality, “you can knock, but nobody’s home” [50].
Schizotypal personality, “I’m eccentric, different, strange” [50].
Paranoid personality, “you can’t trust anybody” [50].
Borderline personality, “I will be very angry, if you try to leave me” [50].
The sadistic personality, “I will savour your suffering” [50]. This particularly refers to criminal autistic psychopathy and serial killers.
Narcissistic personality, “my command is your wish” [50].
The future of psychiatry will be neurodevelopmental. Psychiatrists will focus on these conditions. Mild psychiatric conditions will be dealt with by psychiatric counsellors and psychologists, using psychotherapeutic interventions. This will allow psychiatrists to become neuropsychiatrists which they are all already moving towards. The “blaming” culture of attributing these disorders to mothers’ inadequacies will then be at an end. The neurodevelopmental spectrum is far wider and far more important than suggested by DSM 5 [2, 3].
\nIntechOpen - where academia and industry create content with global impact
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\n\nBut, one thing we have in common is -- we are all scientists at heart!
\n\nSara Uhac, COO
\n\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
\n\nAdrian Assad De Marco
\n\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\n\nDr Alex Lazinica
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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:null,institution:null},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"417317",title:"Mrs.",name:"Chiedza",middleName:null,surname:"Elvina Mashiri",slug:"chiedza-elvina-mashiri",fullName:"Chiedza Elvina Mashiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"352140",title:"Dr.",name:"Edina",middleName:null,surname:"Chandiwana",slug:"edina-chandiwana",fullName:"Edina Chandiwana",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"342259",title:"B.Sc.",name:"Leonard",middleName:null,surname:"Mushunje",slug:"leonard-mushunje",fullName:"Leonard Mushunje",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"347042",title:"Mr.",name:"Maxwell",middleName:null,surname:"Mashasha",slug:"maxwell-mashasha",fullName:"Maxwell Mashasha",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Midlands State University",country:{name:"Zimbabwe"}}},{id:"2941",title:"Dr.",name:"Alberto J.",middleName:"Jorge",surname:"Rosales-Silva",slug:"alberto-j.-rosales-silva",fullName:"Alberto J. Rosales-Silva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"437913",title:"Dr.",name:"Guillermo",middleName:null,surname:"Urriolagoitia-Sosa",slug:"guillermo-urriolagoitia-sosa",fullName:"Guillermo Urriolagoitia-Sosa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"435126",title:"Prof.",name:"Joaquim",middleName:null,surname:"José de Castro Ferreira",slug:"joaquim-jose-de-castro-ferreira",fullName:"Joaquim José de Castro Ferreira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Aveiro",country:{name:"Portugal"}}},{id:"437899",title:"MSc.",name:"Miguel Angel",middleName:null,surname:"Ángel Castillo-Martínez",slug:"miguel-angel-angel-castillo-martinez",fullName:"Miguel Angel Ángel Castillo-Martínez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"289955",title:"Dr.",name:"Raja",middleName:null,surname:"Kishor Duggirala",slug:"raja-kishor-duggirala",fullName:"Raja Kishor Duggirala",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jawaharlal Nehru Technological University, Hyderabad",country:{name:"India"}}}]}},subseries:{item:{id:"27",type:"subseries",title:"Multi-Agent Systems",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11423,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"275140",title:"Dr.",name:"Dinh Hoa",middleName:null,surname:"Nguyen",slug:"dinh-hoa-nguyen",fullName:"Dinh Hoa Nguyen",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRbnKQAS/Profile_Picture_1622204093453",institutionString:null,institution:{name:"Kyushu University",institutionURL:null,country:{name:"Japan"}}},{id:"20259",title:"Dr.",name:"Hongbin",middleName:null,surname:"Ma",slug:"hongbin-ma",fullName:"Hongbin Ma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRhDJQA0/Profile_Picture_2022-05-02T08:25:21.jpg",institutionString:null,institution:{name:"Beijing Institute of Technology",institutionURL:null,country:{name:"China"}}},{id:"28640",title:"Prof.",name:"Yasushi",middleName:null,surname:"Kambayashi",slug:"yasushi-kambayashi",fullName:"Yasushi Kambayashi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOQxQAO/Profile_Picture_1625660525470",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}}]},onlineFirstChapters:{paginationCount:8,paginationItems:[{id:"83117",title:"Endothelial Secretome",doi:"10.5772/intechopen.106550",signatures:"Luiza Rusu",slug:"endothelial-secretome",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Luiza",surname:"Rusu"}],book:{title:"Periodontology - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11566.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"83087",title:"Role of Cellular Responses in Periodontal Tissue Destruction",doi:"10.5772/intechopen.106645",signatures:"Nam Cong-Nhat Huynh",slug:"role-of-cellular-responses-in-periodontal-tissue-destruction",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Periodontology - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11566.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82654",title:"Atraumatic Restorative Treatment: More than a Minimally Invasive Approach?",doi:"10.5772/intechopen.105623",signatures:"Manal A. 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