Mihaela Vladu

By Anca Mihaela Hâncu, Florin Mihălțan, Mihaela Ionela Vladu and Maria Moța

Since chronic obstructive pulmonary disease COPD and obesity became global public health challenges, the nutritional status evaluation is more important. How malnutrition and obesity will impact COPD prognosis and treatment is relevant and we considered need a separate approach. The new adiposity based chronic disease concept explains the role played by adiposity, and important studies, like European Community Health Survey ECRHS are highlighting the correlation between adiposity and lung function decline. On the other side, malnutrition decreases effort capacity and impairs the strength of respiratory muscles. Foods, nutrients and dietary patterns are influencing COPD prognosis and Mediterranean Diet, integrated in a healthy lifestyle should be part of COPD management. The important benefic role played by fibers, whole grains, combined with anti-inflammatory and antioxidant effects of fruits and vegetables, together with poly-unsaturated fatty acids PUFA, fish, vitamins and minerals, is detailed below, in contrast with the detrimental role of Western Diet. A multidisciplinary approach in COPD should be considered, integrating lifestyle interventions as important tools in COPD management.

Part of the book: Chronic Obstructive Pulmonary Disease

By Adina Mitrea, Ionela Mihaela Vladu, Maria Magdalena Rosu, Diana Clenciu, Eugen Mota and Maria Mota

Insulin resistance is the most important characteristic of both metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D). It is estimated that MetS has a prevalence of up to 35% in the general population, rising up to 72% in individuals with T2D. Furthermore, insulin resistance promotes lipotoxicity through an increased free fatty acids flux, leading to both liver and heart disorders. Thus, recent studies have proven the association of metabolic dysfunction-associated fatty liver disease (MAFLD) with MetS and T2D. Interestingly, recent data incriminate the same mechanism for the development of metabolic cardiomyopathy, also known as cardiometabolic heart failure. The aim of this paper is to review the most important data regarding the association of T2D with the classic and the newer elements of the MetS, as well as to emphasize the molecular mechanisms that are accountable for this linkage and the possible therapeutic prospects that could influence these pathologies.

Part of the book: Type 2 Diabetes in 2024 - From Early Suspicion to Effective Management
[Working title]