\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"3691",leadTitle:null,fullTitle:"Advances in Robotics, Automation and Control",title:"Advances in Robotics, Automation and Control",subtitle:null,reviewType:"peer-reviewed",abstract:"The book presents an excellent overview of the recent developments in the different areas of Robotics, Automation and Control. 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She received a Ph.D. in Computing Sciences from the University of Technology, Sydney, and her research focuses on e-commerce, e-service, digital service platforms, and human–technology innovation in diverse cultures. As a leading researcher, she completed projects for the Australian Information Industry Association (AIIS) and the Department of Foreign Affairs and Trade (DFAT), Australia. She is currently conducting a project for the Asian Productivity Organization (APO). Her research contributions are well-known internationally. As a visiting scholar at the Georgia Institute of Technology, US (2012), Dr. Kang engaged in an ICT international development project. 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In the course of this process, many different chemical, physical, microbiological, and sensory reactions are involved. Microorganisms play an essential role, since alcoholic fermentation and frequently also malolactic fermentation are fundamental steps in winemaking. During these fermentation steps, the evolution of certain chemical compounds depends directly on their interaction with microorganisms, thereby resulting in many of the characteristic and desirable flavors in wine [1]. Conversely, microorganisms can also contaminate and spoil the wine in several steps of the winemaking procedure, causing re-fermentation, off-flavors, volatile acidity, and bottle explosion. Moreover, microorganisms can produce compounds that are hazardous for human health, such as biogenic amines [2]. The ultimate quality of wines and their commercial value are therefore directly associated with those microflora which are beneficial; nevertheless, microbial spoilage of wine can lead to a number of drawbacks and economic losses for the wine industry. It is thus essential to monitor the entire winemaking process in the endeavor to avoid contamination caused by microorganisms. This can be achieved using chemical preservatives and/or certain physical treatments designed to inactivate microorganisms, inhibit their growth, or directly separate them physically from wine.
The main yeasts regarded as true spoilage strains in wine are
Lactic Acid Bacteria (LAB) are responsible for malolactic fermentation (MLF), but can also negatively affect the quality of wines as spoilage microorganisms when they proliferate at the incorrect time during winemaking [6]. Wine-associated microbial LAB genera are
At present, the main strategy applied to control spoilage microorganisms along the winemaking process is the addition of sulfur dioxide (SO2), a compound which is able to ensure antioxidant protection and microbiological stability. Although SO2 is a highly effective and inexpensive preservative widely used in the wine industry, concerns have been raised regarding its potentially adverse effects on human health. The general trend in the wine industry is thus currently to reduce SO2 content, or even to eliminate it altogether [7].
Dimethyl dicarbonate (DMDC), lysozyme, and sorbic acid are chemical compounds proposed as alternatives to SO2, and they are already allowed as antimicrobials in winemaking by the OIV. Although they have proven effective against certain wine spoilage microorganisms, at their maximum permitted doses none of them is sufficiently effective against the entire range of microorganisms of concern [7].
Microfiltration, on the other hand, is a common physical procedure applied in winemaking for purposes of microbial stabilization. However, this technique is only applied before bottling and has some drawbacks due to its potentially deleterious effects on flavor and color properties of wines, depending on filter media and intrinsic wine characteristics. Sterile filtration presents further practical problems associated with frequent fouling, the high cost of filters, their management, and the possible recontamination of wines during bottling [8]. Heat treatments, despite their well-known high efficacy in terms of microbial inactivation, are not commonly used in wineries due to the negative effects of high temperature on the valuable sensory properties of wine [9]. Generally, thermal pasteurization is only applied to low-medium quality wines prior to bottling.
Similarly, emerging preservation techniques have been proposed for the microbial stabilization of wines. High hydrostatic pressure (HHP) is one of the most widely studied methods, and it has proven effective against most of the target microorganisms in wine [10]. However, due to the necessity of treating bottled wine and the possible acceleration of unwanted chemical reactions, along with the high cost and small flexibility of HPP devices, is ultimately not the most feasible technique for wineries [11]. Ultrasound, ultraviolet light, ionizing radiation, ultra-high pressure homogenization (UHPH), and microwaves have been also investigated for wine, for must, and even for barrel sterilization [12, 13, 14, 15, 16, 17]. The main recent studies have focused on these techniques’ lethal efficacy, but it is still necessary to obtain further knowledge about their effects on sensory quality and their actual feasibility at an industrial scale. Moreover, none of these innovative physical technologies is yet approved for wine stabilization by the OIV, except for HHP and UHPH.
In order to meet consumer demands, the wine industry is thus attempting to find new strategies to reduce or eliminate the use of SO2. However, the chosen alternative technique should ensure that the levels of inactivation required for stabilization are achieved in each step of the winemaking process, without any detectable effect on sensorial and physicochemical properties of wine.
During processing with pulsed electric fields (PEF), products are subjected to very short pulses (μs) of high voltage (kV). The applied external voltage generates an electric field which, if intense enough, causes an electrical breakdown of the cell’s cytoplasmic membrane. This phenomenon, referred to as electroporation, may cause the inactivation of vegetative cells of microorganisms, among other effects. The capability of PEF to inactivate microorganisms at temperatures that do not affect the flavor, color, or nutrient value of foods is highly attractive for the food industry.
PEF processing involves the intermittent application of direct-current voltage pulses (kV) for very short periods through a material placed between two electrodes. A typical PEF setup for food processing therefore includes a charging unit, an energy storage unit, and a switching unit that triggers pulse formation and releases the electrical pulses in the treatment chamber (Figure 1) [18]. According to the triggering system used for discharging the stored energy, the shape of the pulses delivered in the treatment chamber is either exponential or square. A PEF treatment chamber is composed of two electrodes held in position by insulating material, which forms an enclosure to contain the product to be treated. Parallel electrode and collinear configuration are the two proposed designs for the microbial decontamination of liquid foods by PEF [19]. Parallel electrode configuration hinders the formation of a uniform electric field in the treatment zone, whereas in a collinear treatment chamber the distribution of the electric field in the treatment zone is inhomogeneous. Nevertheless, the collinear chamber’s higher load resistance, the configuration’s overall lower energy requirements, and the circular section similar to the pipes used in food processing plants are nevertheless the reasons why collinear chambers are the ones currently used in industrial applications.
Simplified diagram of an electrical circuit of a PEF generator. The different pulse shapes (exponential or square) and chamber geometries (parallel and collinear electrodes) used for the application of PEF treatments in continuous conditions are plotted. The main processing parameters of PEF technology are shown below.
The effectiveness of PEF processing depends on several parameters, among which the ones most often used to describe the intensity of an applied PEF treatment are: electric field strength, processing time, total specific energy input, and temperature (Figure 1). Electric field strength depends on the external voltage applied, as well as on the distance between the electrodes. Treatment time represents the product’s exposure time to the electric field, and depends on the number of applied pulses as well as on the pulse width. The treatment’s specific energy (energy applied per mass unit) is dependent on the applied voltage, the pulse width, the number of pulses and the treatment chamber’s resistance. Treatment chamber resistance varies according to its geometry and the product’s conductivity. Finally, temperature is the other parameter to be considered in the evaluation of the efficiency of PEF processing in microbial inactivation. Inactivation usually increases at a higher temperature of the treatment medium – even within temperature ranges that are not otherwise lethal for microorganisms [20].
After the application of a PEF treatment, the presence of nucleic acid, proteins, and other components of the microbial cytoplasm such as adenosine triphosphate (ATP) has been observed in the medium surrounding the microorganisms. These observations suggest that PEF causes the formation of local defects or pores (electroporation), thereby leading to an increment of cell membrane permeability. Depending on the intensity of the treatment applied (electric field strength, processing time, specific energy) and cell characteristics (size, shape, orientation within the electric field), the electroporation of the cytoplasmic membrane can be either reversible or irreversible. It is reversible if the bilayer returns spontaneously to its initial state by recovering membrane integrity. If structural changes in the lipid bilayer due to PEF treatment are permanent, electroporation is irreversible. Permanent electroporation causes uncontrolled molecular transport across the membrane, hinders the cells’ homeostatic capacity, and eventually leads to microbial death.
The electroporation of the cytoplasmic membrane caused by PEF indicates that this technology could be an effective procedure the inactivation of vegetative bacteria cells. But bacterial spores, which are a resting stage of some bacteria such as
PEF treatments have been shown to cause microbial inactivation of vegetative cells of bacteria, yeast, and molds. Bacterial spores are resistant to PEF; nevertheless, since spores are not able to proliferate under acidic conditions, PEF represents a worthwhile alternative for the stabilization of acidic food such as must and wine. To implement PEF technology as a preservation method in wineries, it would be essential to determine the target microorganisms in every step of its application, and to conduct studies to prove that it ensures the level of microbial decontamination required to avoid spoilage. Finally, optimized PEF conditions should be applicable at an industrial scale without any negative effect on the appreciated quality properties of wine.
Several studies have demonstrated the potential of PEF for the inactivation of bacteria and yeast in must and wine. Figure 2 shows the different winemaking steps in which the effectiveness of PEF for microbial decontamination and/or control of the microbial population in must or wine has been investigated. The main results obtained in those studies are described below.
Steps of winemaking in which pulsed electric fields have potential application for microbial control and decontamination.
PEF has proven highly effective in the inactivation of diverse microorganisms present in several kinds of fruit juice, including grape juice [21, 22, 23]. Reduction rates ranging from 2.0 to 4.0 log cycles were obtained by PEF (35 kV/cm, 1 ms) in must contaminated by a mixture of spoilage yeast and bacteria, such as
Studies in near-actual winemaking conditions have been conducted to evaluate the potential of PEF for replacing SO2 prior to alcoholic fermentation, with the objective of stabilizing the must and thus facilitating the growth of the culture starters. PEF treatments in must at 35 kV/cm for 1 ms was shown to be effective for controlling the microbial population before the inoculation of the yeast strains selected for alcoholic fermentation. The wines obtained after the alcoholic fermentation of PEF-treated must do not show any change in terms of their volatile profile, nor any modification of their characteristics after subsequent aging in bottles in comparison to wines added with SO2 [29, 30]. Alternatively, the use of non-
Therefore, must stabilization by PEF is proving to be a good alternative for the reduction or elimination of the SO2 dose, thereby facilitating the implementation of selected
Although
González-Arenzana et al. tested the efficacy of PEF treatments in Tempranillo red wine at 17, 21 and 23 kV/cm (from 60 to 95 kJ/kg) in the inactivation of 25 different species of wine-associated microbiota [33]. Inactivation levels ranged from 1.70 to 3.04 log units for yeasts, from 1.01 to 4.16 for LAB, and from 0.64 to 4.94 for AAB. Similarly, Abca & Evrendilek investigated the effectivity of PEF treatments against a series of microbial strains suspended in red wine [34]. A PEF treatment at 31 kV/cm caused a reduction of more than 5.0 log cycles in the yeast population of
The application of PEF as an alternative to the addition of SO2 in sweet wines to prevent re-fermentation was investigated by Delsart et al. [35]. A PEF treatment (20 kV/cm, 320 kJ/kg) inactivated 3.0 and 4.0 log cycles for
Attending to new consumer trends toward overall reduction of alcohol intake, wineries are producing low-alcohol wines [36]. Lower alcohol concentration might nevertheless lead to a higher risk of proliferation of spoiling or undesirable microorganisms in wine. PEF treatments (40 kV/cm, 250 μ) achieved inactivation levels up to 1.5 and 2.0 log cycles of LAB and yeasts in wines which had only 8.5% alcohol content [37].
Furthermore, a PEF treatment of 158 kJ/kg (33 kV/cm) has been validated as an improvement of the implementation of MLF starters in the production of four Tempranillo Rioja wines. The PEF-treated wines that were subjected to MLF preserved all their sensorial properties, as determined by sensory analysis through an expert panel [38].
PEF inactivation of LAB strains involved in the MLF of wine has been studied by different authors. Among the microorganisms investigated, Puértolas et al. found that
Few studies have been conducted on the inactivation of microorganisms after malolactic fermentation. González-Arenzana et al. observed that after the MLF of three wines, the application of a PEF treatment (95 kJ/kg, 23 kV/cm) in combination with a low SO2 concentration (15 mg/L) had similar or even greater effectivity than an increased dose of SO2 (30 mg/L) in the microbial stabilization of wine [41]. PEF treatments alone, or combined with SO2, allowed for a significant reduction in the overall population of the main microbial strains of yeasts, LAB, and ABB. Moreover, stabilization by PEF treatments was effective in inhibiting microbial growth after six months of storage, with no changes in physicochemical and sensory properties in comparison to wines stabilized by SO2.
Aging in oak barrels is one of the key steps in the production of high-quality wine, due to its gradual development in terms of aroma, color, and stability [42]. Oak wood is a porous material that is necessary for air exchange and for the maintenance of low oxidation conditions in wine during the aging process, but oak wood barrels are extremely difficult to clean and sanitize. They therefore present an ideal niche for microbial proliferation, and can be a source of contamination for subsequent batches of wine [43]. This is a great concern in wineries – especially in the case of
Aged preservative-free wine in oak barrels was successfully treated by PEF, with a high-level reduction in the population of the main naturally present strains [44]. However, the recovery of some of the main microorganisms involved in aging was observed in control and PEF-treated wines after 5–9 months of storage. Therefore, different PEF parameters should be tested in order to optimize PEF conditions in this scantly investigated step of winemaking. Further studies regarding the effect of PEF treatments on valuable aging characteristics prior to bottling should be carried out, as well as on the evolution of the microbial population during these long storage periods.
One of the main concerns regarding the use of preservation techniques in the wine industry lies in their potentially negative effects on the quality characteristics of wines. As a non-thermal technology, Pulsed Electric Fields presents the advantage of having great effectivity in terms of microbial decontamination with minimum alteration of the physicochemical and nutritional properties of foods [45]. A series of studies have reported that PEF has no significant effects on the main physicochemical and sensorial quality parameters of must and wine, immediately after treatment or after a period of storage [24]. What is more, some of these studies have reported better sensory attributes for PEF-decontaminated wines in comparison with untreated wines or wines treated with SO2.
After six months of storage, the physicochemical composition of three PEF-treated wines showed no differences in pH, total acidity, anthocyanin content, or total polyphenol index, but they displayed better quality in terms of volatile acidity and color intensity [41]. Moreover, sensorial analysis indicated that the organoleptic properties of the wines treated with PEF combined with SO2 (15 mg/L) had the highest scoring values in comparison with wines treated only with PEF or treated only with SO2 (30 mg/L). In white wines, intense PEF treatments of 20 kV/cm and 6 ms had an effect similar to the addition of sulfur dioxide (250 mg/L), but with a notable decrease of the browning effect [35].
Moreover, the application of PEF treatments combined with mild temperatures has been proven to significantly increase microbial inactivation levels [22, 23]. In this context, Abca & Evrendilek studied changes in the attributes of wine treated by PEF combined with different temperatures for purposes of microbial inactivation [34]. For all the strains studied (
Until now, no study has shown any significant negative effects on the sensory properties of wine treated by PEF. Further research should nevertheless be carried out with optimized PEF-parameters for microbial stabilization in the different steps of winemaking, and featuring different grape/wine varieties.
Among potentially negative effects of PEF, another important concern is the possible migration of ion metals from the electrodes to the food matrix. Although certain authors have reported the release of ion metals, this phenomenon seems to be thoroughly dependent on electrode material and geometry, as well as on processing parameters (conductivity, electric field strength, total specific energy, pulse width) [46, 47]. In wine, the increase of certain metal ions (e.g. arsenic, calcium, mercury, iron, copper, magnesium, and selenium, among others) can cause turbidity and a metallic taste; it can even represent a health risk for consumers. In red wine, Abca & Evrendilek did not observe significant differences in the concentration of 13 different metal ions between PEF and control wines, even at highest-intensity PEF conditions (31 kV/cm, 30°C) [34]. Similarly, no differences in iron and chromium concentration were detected in Cabernet Sauvignon red wine subjected to 34 and 53 kV/cm (50us) treatments [39]. Although those treatments slightly increased the concentration of nickel in the PEF-treated wines the levels reached were below the maximum limits permitted in food products.
Microorganisms in winemaking are as necessary as they are undesirable, depending on the strain and/or the time it proliferates. The growth of spoilage microorganisms in must and wine not only exerts a considerable influence on consumer acceptance, but can also lead to uncountable economic losses. Currently, the spoilage of wine by microorganisms is mainly controlled by applying SO2. However, due to the current global concern about the negative effects of SO2 on human health, the wine industry is facing the challenge of attempting to reduce or eliminate its use. Proposed chemical or physical alternatives are insufficient or/and non-feasible for implementation as microbial stabilization procedures in the wine industry.
Pulsed Electric Fields emerge as a thoroughly suitable alternative technique for the stabilization of must and wine, or as a technique combined with low doses of SO2 to ensure antioxidant protection. PEF efficacy has been studied against the main wine-related spoilage microorganisms along the different winemaking stages, but mostly under lab-scale or pilot plant conditions. Best results have been obtained when PEF was combined with mild treatment temperatures and/or with low concentrations of SO2, or with other preservatives. Furthermore, several studies have reported to have found no negative effects or changes in the sensory quality of wines treated with PEF.
PEF technology is currently being applied in a number of industrial food processing applications. Thus, the development and optimization of PEF devices and chambers is accelerating in order to adapt them to current demands while facilitating the industrial implementation of such new techniques to food. The devices’ flexibility has been highly improved, along with different types of treatment chambers, depending on the type of matrix and on treatment conditions.
The International Organization of Vine and Wine (OIV) recently approved the application of PEF to grapes in order to enhance and reduce maceration time in winemaking [48]. The technology is currently being evaluated as a microbial stabilization and decontamination process. The OIV resolutions thus suggest that PEF is a gentle technology without negative consequences for must or wine, but offering interesting improvements in terms of their quality. The applicability of PEF in several other winemaking steps such as maceration or aging-on-lees, along with the current feasibility of scale-up potential, makes this procedure thoroughly attractive for future implementation as a highly versatile technology in the wine industry. Furthermore, the energetic requirements for must/wine PEF-optimized pasteurization can ranged from 20 to 200 kJ/kg. Thus, the power consumptions imply very low costs in comparison with the traditional techniques and the innovative ones suggested.
Generally, however, the ranges of PEF parameters studied for purposes of microbial decontamination (at laboratory scale), are still very intense in comparison with the ones used in grape electroporation (high-intensity voltages or long treatment times). Such intense conditions have certain drawbacks for implementation in wineries due to the power limitation of current PEF devices. This implies that PEF should be applied at very low flow rates, which are not feasible in winemaking on an industrial scale. The current challenge lies therefore in studying low and mild PEF conditions not investigated so far in-depth: PEF alone, or in combination with other methods. One of the most promising combinations is the application of PEF treatments in association with mild temperatures or/and with reduced doses of SO2. A reduced amount of studies have already proven the synergetic effect that emerges between these methods when applied in combination. Thus, in order to successfully implement PEF technology in wineries for purposes of microbial decontamination, it will be necessary to define the lowest-intensity PEF parameters which, combined with mild temperatures and reduced-SO2, have the highest synergetic effect. This would allow for a considerable increase in the processing capacity of PEF units, thereby facilitating this technique’s industrial application in the wine industry without affecting sensory properties, while attending to widespread demands for the reduction of SO2.
Polynomial factorization over a field is very useful in algebraic number theory, for prime ideal factorization. It is also important in extensions of valuations, etc. For valued field extensions, the determination of irreducible polynomials was the focus of interest of many authors (cf. [1, 2, 3, 4, 5, 6, 7]). In 1850, Eisenstein gave one of the most popular criterion to decide on irreducibility of a polynomial over
Let
Let
where
Let
The following are the relevant theorems from Newton polygon. Namely, theorem of the product and theorem of the polygon. For more details, we refer to [15].
Let
If the triangular inequality is replaced by an ultra-inequality, namely
Conversely, assume that there exists
Show that if
More precisely, show that if
Let
Show that if
Let
Let
Let
Show that
Determine the characteristic elements of
Show that
For every polynomial
For every polynomial
Let
Any convergente sequence of
The converse is false, indeed, it suffices to consider the valued field
We say that
Let
Show that if
Assume that
Let
Furtheremore, the completion is unique up to a valued fields isomorphism.
Now we come to an important property of complete fields. This theorem is widely known as Hensel’s Lemma. For the proof, we refer to ([16], Lemma 4.1.3).
The following example shows that for any prime integer
Show that
We have the following apparently easier characterization of Henselian fields. For the proof, we refer to ([16], Lemma 4.1.1).
In particular, we conclude the following characterization of the henselization
Let
The notion of key polynomials was introduced in 1936, by MacLane [17], in the case of discrete rank one absolute values and developed in [18] by Vaquié to any arbitrary rank valuation. The motivation of introducing key polynomials was the problem of describing all extensions of
We say that
We say that a polynomial
It is easy to prove the following lemma:
Let
Let
Completing by zeros;
□
The following Lemma makes a one–one correspondence between the absolute value of
Moreover, the inequality
In particular, since
Let
For the second point, let
For
For
□
Show that
Based on absolute value, the following theorem gives an hyper bound of the number of monic irreducible factors of monic polynomials. In particular, Corollary 3.9 gives a criterion to test the irreducibility of monic polynomials.
Now, let
For the residue degree and ramification index, since
How that
Conclude a new proof for
Let
Combining Lemma 3.4 and Theorem 3.8, we conclude the following result:
Let
Let
Let
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He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"7",type:"subseries",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/337938",hash:"",query:{},params:{id:"337938"},fullPath:"/profiles/337938",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var m;(m=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(m)}()