\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"740",leadTitle:null,fullTitle:"Neck Dissection - Clinical Application and Recent Advances",title:"Neck Dissection",subtitle:"Clinical Application and Recent Advances",reviewType:"peer-reviewed",abstract:"Neck Dissection - Clinical Application and Recent Advances is a leading book in neck surgery and represents the recent work and experiences of a number of top international scientists. 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He has had many publications and contribution to science by advocating many surgical procedures and research in cancer surgery and flap reconstruction, TMJ surgery and maxillofacial injuries, orbit tumors and missile war injuries of the face with advancing surgery of war injuries of the face worldwide. He has contributed to research in cancer and has developed post graduate studies in maxillofacial surgery in Iraq. He is the Editor of Neck Dissection - Clinical Application and Recent Advances (February, 2012, IntechOpen), Surgical Reconstruction of the Temporomandibular Joint (2013), Germany, Editor of the book Disease of the TMJ, Surgical Reconstruction, Clinical & Experimental Studies (April, 2014, Science PG), Missile War Injuries of the Face, Maxillofacial Injuries in Road Traffic (book published by Science PG, 2014), and Jaw Lymphoma and Orofacial Tumors (2015, book published by Science PG), editor of the book "Bone Grafting - Recent Advances with Special References to Cranio-Maxillofacial Surgery" (December, 2018, IntechOpen), editor of the book Craniofacial Deformity and Normal Variations of Jaws Relationship (OMICS International, in press). He is Co-editor of the book Maxillofacial Surgery and Craniofacial Deformity (2020, IntechOpen). He is a member of the editorial board of 29 international distinguished journals, President of Society of Iraqi Maxillofacial Surgery, a founding member of the International Society of Head Neck Trauma, 2015, London, and Chairman of the Department of Maxillofacial Surgery, College of Dentistry, University of Baghdad 1982-2000. He is a member of the Council of College of Dentistry (1975-2000), Founder and Chairman council of Maxillofacial Surgery, Iraqi Board for Medical Specializations (1993-2010). He has about 129 papers published and is an eminent figure in craniofacial surgery in the Middle East. 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Generally, people spend about 90% of their time indoors where they are exposed to chemicals, particulate matters, biological contaminants and possibly carcinogens. In particular, the air quality at hospitals carries with it risks for serious health consequences for medical staff as well as patients and visitors. This book is a study of atmospheric air pollution and presents ways we can reduce its impacts on human health. It discusses tools for measuring IAQ as well as analyzes IAQ in closed buildings. It is an important documentation of air quality and its impact on human health.",isbn:"978-1-78985-280-6",printIsbn:"978-1-78985-279-0",pdfIsbn:"978-1-78984-172-5",doi:"10.5772/intechopen.77883",price:100,priceEur:109,priceUsd:129,slug:"atmospheric-air-pollution-and-monitoring",numberOfPages:98,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"2538dc9777b41324f25fe3c6e26df425",bookSignature:"Abderrahim Lakhouit",publishedDate:"April 15th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8052.jpg",keywords:null,numberOfDownloads:4590,numberOfWosCitations:0,numberOfCrossrefCitations:3,numberOfDimensionsCitations:5,numberOfTotalCitations:8,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"January 17th 2019",dateEndSecondStepPublish:"March 6th 2019",dateEndThirdStepPublish:"May 5th 2019",dateEndFourthStepPublish:"July 24th 2019",dateEndFifthStepPublish:"September 22nd 2019",remainingDaysToSecondStep:"3 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"250788",title:"Dr.",name:"Abderrahim",middleName:"A.L",surname:"Lakhouit",slug:"abderrahim-lakhouit",fullName:"Abderrahim Lakhouit",profilePictureURL:"https://mts.intechopen.com/storage/users/250788/images/system/250788.jpg",biography:"Dr. Abderrahim Lakhouit has a PhD in Civil and Environmental\nEngineering from the University of Sherbrooke, Quebec, Canada. He has two master’s degrees in Environmental Engineering\nand Renewable Energy and Energy Efficiency. He is an assistant\nprofessor at the University of Tabuk, Kingdom of Saudi Arabia.\nPreviously he worked as a teaching assistant at Canadian universities. Dr. Lakhouit is also a researcher and has published articles\nin international journals such as Chemosphere. He is an associate and guest editor\nas well as reviewer for many international journals, including Waste Management,\nEnvironments, and others. He is an active member in the Association of Environmental Engineering and Science Professors (AEESP).",institutionString:"University of Tabuk",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Tabuk",institutionURL:null,country:{name:"Saudi Arabia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"776",title:"Air Pollution",slug:"engineering-environmental-engineering-air-pollution"}],chapters:[{id:"69410",title:"Introductory Chapter: Indoor Air Quality in the Closed Building",slug:"introductory-chapter-indoor-air-quality-in-the-closed-building",totalDownloads:502,totalCrossrefCites:0,authors:[{id:"250788",title:"Dr.",name:"Abderrahim",surname:"Lakhouit",slug:"abderrahim-lakhouit",fullName:"Abderrahim Lakhouit"}]},{id:"71554",title:"Numerical Analysis of Indoor Air Quality in Hospital Case Study: Bronchoscopy Unit",slug:"numerical-analysis-of-indoor-air-quality-in-hospital-case-study-bronchoscopy-unit",totalDownloads:615,totalCrossrefCites:0,authors:[{id:"250788",title:"Dr.",name:"Abderrahim",surname:"Lakhouit",slug:"abderrahim-lakhouit",fullName:"Abderrahim Lakhouit"},{id:"318121",title:"Dr.",name:"Hanaâ",surname:"Hachimi",slug:"hanaa-hachimi",fullName:"Hanaâ Hachimi"},{id:"318122",title:"Dr.",name:"Douha",surname:"Belaidi",slug:"douha-belaidi",fullName:"Douha Belaidi"},{id:"318123",title:"Dr.",name:"Aouatif",surname:"Amine",slug:"aouatif-amine",fullName:"Aouatif Amine"}]},{id:"66951",title:"Prediction of Agricultural Contaminant Concentrations in Ambient Air",slug:"prediction-of-agricultural-contaminant-concentrations-in-ambient-air",totalDownloads:891,totalCrossrefCites:0,authors:[{id:"16116",title:"Dr.",name:"Steven",surname:"Cryer",slug:"steven-cryer",fullName:"Steven Cryer"},{id:"292345",title:"Dr.",name:"Ian",surname:"Van Wesenbeeck",slug:"ian-van-wesenbeeck",fullName:"Ian Van Wesenbeeck"}]},{id:"67266",title:"Atmospheric Air Pollution in Nigeria: A Correlation between Vehicular Traffic and Criteria Pollutant Levels",slug:"atmospheric-air-pollution-in-nigeria-a-correlation-between-vehicular-traffic-and-criteria-pollutant-",totalDownloads:744,totalCrossrefCites:3,authors:[{id:"271021",title:"Dr.",name:"Yahaya",surname:"Aliyu",slug:"yahaya-aliyu",fullName:"Yahaya Aliyu"},{id:"302502",title:"Dr.",name:"Joel",surname:"Botai",slug:"joel-botai",fullName:"Joel Botai"},{id:"302503",title:"Mr.",name:"Aliyu",surname:"Abubakar",slug:"aliyu-abubakar",fullName:"Aliyu Abubakar"},{id:"302505",title:"Mr.",name:"Jimoh",surname:"Suleiman",slug:"jimoh-suleiman",fullName:"Jimoh Suleiman"},{id:"302506",title:"Mr.",name:"Mohammed",surname:"Shebe",slug:"mohammed-shebe",fullName:"Mohammed Shebe"},{id:"302507",title:"Mr.",name:"Muhammed",surname:"Bichi",slug:"muhammed-bichi",fullName:"Muhammed Bichi"},{id:"303106",title:"Dr.",name:"Terwase",surname:"Youngu",slug:"terwase-youngu",fullName:"Terwase Youngu"}]},{id:"67898",title:"Long-Distance LIDAR Mapping Schematic for Fast Monitoring of Bioaerosol Pollution over Large City Areas",slug:"long-distance-lidar-mapping-schematic-for-fast-monitoring-of-bioaerosol-pollution-over-large-city-ar",totalDownloads:946,totalCrossrefCites:0,authors:[{id:"297966",title:"Prof.",name:"Ivan",surname:"Nedkov",slug:"ivan-nedkov",fullName:"Ivan Nedkov"}]},{id:"68415",title:"Smart Environment Monitoring System Using Wired and Wireless Network: A Comparative Study",slug:"smart-environment-monitoring-system-using-wired-and-wireless-network-a-comparative-study",totalDownloads:894,totalCrossrefCites:0,authors:[{id:"292284",title:"Dr.",name:"Tabbsum",surname:"Mujawar",slug:"tabbsum-mujawar",fullName:"Tabbsum Mujawar"},{id:"300961",title:"Prof.",name:"Lalasaheb",surname:"Deshmukh",slug:"lalasaheb-deshmukh",fullName:"Lalasaheb Deshmukh"}]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"287827",firstName:"Gordan",lastName:"Tot",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/287827/images/8493_n.png",email:"gordan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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Because of its exceptionally fast energy conversion rate, long life, and environmental friendliness, dielectric energy storage technology has been used in applications for the electronics and power industries such as wearable electronic devices, hybrid vehicles, and weapon systems [1]. As the trend toward high-performance miniaturized electronic devices continues, the demand for dielectric materials with high energy storage density (
where
Commonly known high-energy storage dielectric materials are mainly biaxially oriented polypropylene (BOPP), polyester, polycarbonate (PC), polyphenylene disulfide, polyurea, polyurethane, and polyvinylidene fluoride [3]. Among many polymers, polyimide (PI) is a type of polymer containing an imide ring on the main chain [4]. PI is widely used in packaging materials, insulation layers, circuit boards, and interlayer dielectrics due to its high tensile strength, excellent mechanical properties, high glass transition temperature (
The chemical groups of a dielectric medium contribute to its molar polarization; as the molar polarization increases, the
Ma et al. [7] used high-throughput density functional theory (DFT) to rationally design high
Kapton PI is an aromatic PI film that has been commercially available since the mid-1960s. Due to its continuous operating temperature of 300–350°C, it is widely used as a high-temperature wire and cable insulation material. At 25°C and 1 kHz, Kapton’s
Heat-resistant PI polymers used as capacitor dielectrics [
The relationship between the dielectric properties of PI and molecular structure can be studied by changing the structure of the aromatic tetracarboxylic dianhydride and diamine monomers used to prepare PI. However, the preparation of the aromatic tetracarboxylic dianhydride is often complex and the yield is low while the synthetic method for phenyl-substituted aromatic diamine is relatively simple, diverse, and high yield. Consequently, modifying the structure of the aromatic diamine monomers has become the primary choice to improve the properties of PIs [10].
Peng et al. [3] used 5,5′-bis[(4-amino)phenoxy]-2,2′-bipyridine (BPBPA) diamine monomer (as shown in Figure 2) and different dianhydrides [BPDA, PMDA, 3,3′,4,4′-Benzophenonetetracarboxylic dianhydride (BTDA), 4,4′-Oxydiphthalic anhydride (OPDA)] to give a series of bispyridyl-containing PIs using a two-step synthesis. The bipyridyl unit enhanced the electronic polarization and coupling: The polarized PI had a εr of ≤7.2, the dielectric loss was ≥0.04, and the energy density was ≤2.77 J cm−3. At the same time, it demonstrated good thermal and mechanical properties.
Dipyridyl-containing diamine monomer [
Tong et al. [4] studied the relationship between molecular structure and properties using a range of modified PIs. In this study, the εr was increased by introducing sulfonyl groups, the loss factor was reduced by introducing flexible bonds, and the Tg was increased by retaining the aromatic structure. The resulting sulfonyl-containing PI with different flexible connections gave high εr (4.50–5.98), low loss coefficients (0.00298–0.00426), high breakdown strength (mostly at 500 MV m−1 or more) and high heat resistance (Tg: 244–304°C) (Figure 3).
Synthesis of sulfo-containing PI [
For the anhydride 3,3′,4,4′-diphenylsulfonetetracarboxylic dianhydride (DSDA-mDS, each repeat unit contains two -SO2-, which has the highest dipole density), the εr was not as high as expected but it can be seen that the two -SO2- units improved the stiffness of the overall chain, hindering the rotation of the dipole. Therefore, in addition to the dipole moment and dipole density, the “effective” dipole is another important factor affecting the value of the εr. Compared to ortho-symmetric OPDA-mDS, para-symmetric PI (OPDA-pDS) was more effective for PI with sulfonyl group (OPDA-pDS) in the diamine moiety (para-para bond). The symmetric structure and low free rotation energy barrier facilitate the alignment of the excimer: The εr increased to 5.98; the dielectric properties were stable at 150°C; the discharge energy density and charge and discharge efficiency increased to 7.04 J cm−3 and 91.3% at 500 MV m−1 respectively [4].
Due to the high polarity of nitrile groups, special classes of PIs containing nitrile units for piezoelectric and other dielectric applications have previously been studied [11]. Kakimoto et al. [12] reported that attaching a polar -CN side group to a PI could increase its εr. Treufeld et al. [11] found that adding a CN dipole to the PI main chain had two main effects: Firstly, because the -CN group is directly connected to the main chain in a 90° configuration, the motion is hindered and generates significant friction with randomly stacked adjacent chains, so dipole motion (such as wobble) is introduced into the PI sample; secondly, by adding the -CN group, the PI becomes more polar, easily contaminated by impurity ions, thereby improving ion mobility. Furthermore, it has been shown that the presence of three nitrile groups on the diamine unit is more effective in improving the εr than one nitrile group. Wang et al. [13] studied and synthesized a series of PIs from a diamine synthesized with three nitrile groups (as shown in Figure 4) and four commercial dianhydride starting materials. All PIs showed a high Tg, thermal stability and excellent mechanical properties; the PI had a εr of 4.7 resulting from the introduction of three highly polar nitrile groups.
Diamine monomer containing three nitrile groups [
Unlike ordinary composite materials, graft polymers, with good properties, were synthesized by Chen et al. [7]. The copper phthalocyanine oligomer (o-CuPc, shown in Figure 5) is a semiconductor material with unique electrical properties (εr > 103) and good thermal stability, used widely in organic optoelectronics, the dye industry, catalysis, electrochromism, and electroluminescence display and other fields. The design and synthesis resulted in a high-εr all-organic polymer material, that is, a CuPc-PI homogeneous block copolymer was prepared (see Figure 6). The CuPc-PI also showed low dielectric loss, high breakdown strength, high Ue, high thermal stability, and good mechanical properties; its overall performance was higher than the direct use of o-CuPc/PI composites obtained using CuPc as the conductive filler [7].
Synthetic copper phthalocyanine oligomer [
Schematic diagram of graft reaction [
Modification of the molecular structure of the polymer can improve its dielectric properties although the effect can be small. Using a simple compounding method with a high εr filler (e.g., ceramic filler, conductive filler), a polymer with a high breakdown field strength can be obtained. This procedure has gained acceptance due to its simple preparation method.
The conductive filler polymer-based composite material can attain a high εr for relatively small additions of filler, and the large increase in εr can be explained by the percolation theory. Adding filler at the percolation threshold will greatly increase the electrical conductivity and εr of the composite material, thereby improving the transition layer between the filler and the matrix. Carbon materials such as carbon nanofibers (CNFs), carbon black, carbon nanotubes (CNTs), graphene, and graphite flakes are most commonly used in recent research. Among these conductive fillers, CNTs are a good choice due to their high electrical and thermal conductivity and high aspect ratios. Wu et al. [14] functionalized multi-walled carbon nanotubes (MWCNTs) with carboxyl groups prior to dispersing into PI nanofibers using electrospinning technology. Hot pressing was then performed to produce high-performance PI/MWCNT composites with a high εr, good mechanical flexibility, and excellent thermal stability. When the concentration of MWCNT was close to the percolation threshold of 12–14 vol%, the material showed a high εr, low breakdown strength, and maximum
Schematic illustration of the film preparation procedure for GO and PI/GO composites [
Adding conductive particles as a filler to the polymer matrix can improve the εr of the polymer composite. When the added amount is close to the percolation threshold, the εr can be significantly increased. However, as the amount of addition increases, a conductive network is formed, and their dielectric loss will increase sharply. In general, nanostructured BT fillers and BT-based nanocrystals are the more promising materials due to their excellent dielectric and ferroelectric properties [16].
Fan et al. [17] studied the relationship between the εr and the temperature for thermosetting PI matrix nanocomposite films containing BT nanoparticles at 103 Hz. Two temperature changes were reported, namely heating from 50 to 150°C and cooling from 150 to 50°C to investigate the effects of the transition of the BT crystal phase and the free volume change in PI on the εr for BT/PI nanocomposite membranes. Theoretical models were also used to predict the εr of composite materials to study the role of the diameter and shape of the nanoparticles. Rajib et al. [18] prepared BT/PI nanocomposites and increased their energy density at high temperatures using different volume fractions to analyze their effect on the dielectric properties. All samples were tested at high temperatures to evaluate their energy storage capacity. The highest Ue was found when the volume fraction of BT was 20% reaching 9.63 J cm−3 at 20°C and 6.79 J cm−3 at 120°C. As a dielectric material, it is expected to maintain a high energy density value at a temperature of 120°C. A pure PI film prepared by Sun et al. [19] showed high breakdown strength (451 kV mm−1) and high energy density (5.2 J cm−3). The introduction of BT nanoparticles increased the εr of the nanocomposite to 6.8, while the dielectric loss was still relatively low (0.012 at 104 Hz). However, a small amount of (3 vol%) BT nanoparticles also caused a significant decrease in the breakdown field strength (275 kV mm−1), which greatly reduced the energy density (1.7 J cm−3) of the BT/PI nanocomposite.
Therefore, for BT/PI nanocomposites, future research may concern improvements in the thermal conductivity of nanocomposites and the formation of interpenetrating networks throughout the polymer matrix. Improvements in this area will make nanocomposites less susceptible to breakdown [19]. Wang et al. [20] successfully prepared BT nanowire/PI (BT-NW/PI) and BT nanoparticle/PI (BT-NP/PI) composites with low volume fractions. Due to strong interfacial polarization, the εr of BT-NW filled composites was greater than that of BT-NP/PI. The εr of the composite containing 5 vol% BT-NW was 6.6 at 100 Hz, which was 94% higher than pure PI (εr = 3.4 at 100 Hz) and 22% higher than that of composite containing 10 vol% BT-NP (εr = 5.4 at 100 Hz). In addition, BT-NW also significantly improved the
Furthermore, the calcination temperature of BT has a significant influence on the εr of the PI/BT-nanocomposite film as shown in Figure 8. The εr of the PI composite film calcined at 1000°C was higher than the PI composite films calcined at 600 and 800°C; when the BT-NF content was 30 vol%, the εr of the BT-NF/PI composite film increased to 26.6 [16]. Beier et al. [21] added Ba0.7Sr0.3TiO3 (BST) nanocrystals to the PMDA-1,3-bis(4-aminophenoxy)benzene (BAPB) PI system to generate nanocomposites. Compared with the εr (2.8) of pure PMDA-BAPB PI, the εr of composites containing 18 vol% BST increased to 6.2; below 1 MHz, the dielectric loss of composite materials with different contents of BST was less than 0.04. At an addition level of 10 vol% BST, the breakdown strength of PMDA-BAPB/BST nanocomposites increased, to reach a maximum value 296 V μm−1, while the energy density of the composite was twice that of pure PMDA-BAPB PI. The observed relative increases in εr and breakdown strength together with the reduction in dielectric loss for the nanocomposite with 10 vol% BST are desirable characteristics for practical applications [21]. Wang et al. [22] prepared PI-based composites with good dielectric properties using CaCu3Ti4O12 (CCTO) and Zr-modified CaCu3Ti3.95Zr0.05O12 (CCTZO) particles as fillers. The results showed that at a filling content of 40 vol%, the εr of the CCTZO/PI composite film could reach a value of 70 at 10 Hz, and this was higher than that of the CCTO/PI composite film under the same conditions; at 150°C, the εr of the CCTZO/PI composite material reached ≈260 [22].
Frequency dependence of dielectric property of 30 vol% BT nanoparticles (a) dielectric permittivity and (b) dielectric loss measured at room temperature [
By changing the design of the inorganic filler, interface problems between the filler and the polymer can be improved, such as poor flake/fiber morphology. The nanosheets can increase the breakdown strength of composites because they provide a uniform insulating center and a curved path for the electrons. Boron nitride nanosheets (BNNSs) have a layered structure like graphene and are wide band gap (6 eV) insulators. Unlike traditional dielectric materials (high-εr ceramics and conductive fillers), polymer/BNNS nanocomposites may provide higher breakdown field strengths. Wan et al. [23] prepared three-phase composites of BNN, BT-fibers, and PI (BNNS@BT-fiber/PI) using in situ polymerization. The combination of BNNS and BT fibers can facilitate the dispersion of BNNS nanosheets in BT fibers, thereby improving energy storage performance. When the content of BNNS@BT-fiber was 20% by weight, the εr of the composite material was 47.57 at room temperature and 43.03 at 200°C at 100 kHz, demonstrating a reasonable thermal stability. At a BNNS@BT-fiber content of 1 wt%, the maximum Ue of the composite at 3438 kV cm−1 was 7.1 J cm−3, that is, about three times that of pure PI [23].
In order to achieve better dispersion and alignment of the filler in the PI matrix, Gu et al. [24] prepared micron boron nitride (mBN)/PI composites by in situ polymerization and electrostatic spinning technology. At 30 wt% mBN, the mBN/PI composite material exhibited a high εr (3.77) and low dielectric loss (0.007); the material also showed good thermal stability (λ = 0.696 W m−1 K−1), a high temperature index (279°C), and Tg was 240°C [24]. Cheng et al. [25] considered that molybdenum disulfide (MoS2) had an appreciable band gap and excellent heat resistance, and prepared MoS2/PI nanocomposite films. Compared with the pure PI film, the εr of the composite film was significantly increased, while the dielectric loss remained relatively low. At a filler content of 1 vol%, the breakdown field strength reached 395 MV m−1, while
Because of its simple method, the compounding of fillers and polymers to produce composite materials has become accepted. However, preparation methods, external conditions, and other complications can give rise to many structural defects and electric field concentrations between the two phases of the filler and the polymer matrix. Therefore, surface treatment of the filler using a coupling agent, or decorative insulating, or conductive particles has become a key area of research [27, 28].
Halloysite (Al2Si2O5(OH)4·2H2O) is an aluminosilicate clay, which has a unique tubular structure. It has a high εr (6–8), but extremely low dielectric loss (10−3). Because there are moderate hydroxyl groups on the surface that can be chemically modified, and suitable surface modification can be performed, halloysite nanotubes (HNTs) may be an ideal filler for the preparation of dielectric polymer-based composites with high εr and low dielectric loss characteristics. Zhu et al. [29] used KH550 (3-aminopropyltriethoxysilane) and polyaniline (PANI) to modify the surface of HNT, and prepared HNT/PI, KH550 modified HNT/PI and PANI-HNT/PI nanocomposite membranes. Among these, at 100 Hz, the PANI-HNT/PI films attained a maximum εr of 17.3, while the dielectric loss was only 0.2. Notably, the prepared composite has high breakdown strength (>110.4 kV mm−1), and a maximum discharge energy density of 0.93 J cm−3; these properties could still be maintained at temperatures ≤300°C [29]. Wang et al. [30] prepared a nanocomposite with high thermal conductivity by introducing amide-functionalized MWCNT [MWCNT@p-phenylenediamine (PPD)] into a PEI matrix, as shown in Figure 9. Compared with unmodified MWCNT, MWCNT@PPD could participate in the in situ polymerization of PEI to form covalent bonds in the matrix, thereby improving the dispersibility of the filler. This method solved the disadvantages of the traditional CNT acid treatment that can destroy their conjugate structure and greatly affect the aspect ratio. The results showed that the thermal conductivity of nanocomposites containing 4.0 wt% MWCNT@ PPD ≤0.43 W m−1 K−1 [30].
Schematic for the preparation of multi-walled carbon nanotubes@azide polyacrylic acid (MWCNT@PPD) [
Yang et al. [27] investigated the dielectric properties of PI incorporating CCTO/Ag nanoparticles (CCTO@Ag). The use of Ag coating to modify the surface of CCTO nanoparticles increased the conductivity of the intermediate layer, thereby enhancing the space charge polarization and Maxwell-Wagner-Sillars effect, improving the electric field distortion. The results showed that when the content of CCTO@Ag was 3 vol%, the εr of PI/CCTO@Ag composites was significantly increased to 103, which was about 30 times the εr of pure PI. At the same time, the dielectric loss was very low at 0.018 [27]. Wang et al. [31] used 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTCA) and TH-615 acrylic-acrylate-amide copolymers to modify BT nanoparticles, and then prepared a BT/PI composite film by in situ polymerization. The results showed that this surface modification method could improve the dispersion uniformity of filler particles in the matrix and improve the interfacial compatibility between the two phases. At 103 Hz, a BT/PI film modified with 8% PBTCA had a εr of 23.5, a dielectric loss of 0.00942, a breakdown strength of 80 MV m−1, and a
However, the covalent functionalization method adopted by Fang et al. [32] reduced the conductivity of graphene by destroying the π-π conjugate structure of graphene. In order to overcome this shortcoming, Feng et al. decorated the surface of rGO with a solid π-π stack by insulating reduced polyaniline (R-PANI) to introduce a space effect and effectively prevent the irreversible agglomeration of rGO. At 1 kHz, the highest εr (25.84) was observed in nanocomposite films containing 20 wt% rGO@R-PANI, and the dielectric loss was 0.11. The εr and dielectric loss of rGO/PI nanocomposite films were 8.23 and 56.4, respectively. Furthermore, the 5 wt% weight loss temperature for 20 wt% rGO@ R-PANI/PI nanocomposite film was 480°C, indicating that the nanocomposite film has great potential in the field of high-temperature dielectric materials [5]. Yue et al. [5] introduced reduced barium titanate (rBT), sintered in a reducing atmosphere (95N2/5H2), to PI without using any modifier or surfactant ingredients in the matrix. Surface defects of rBT and interface interactions between two phases caused by the reducing atmosphere lead to an increase in εr and Ue. Compared with pure PI, the rBT/PI composite with 30 wt% rBT exhibited the following characteristics: The εr at 1000 kHz was ≤31.6 (pure PI = 4.1), the material maintained a low dielectric loss (0.031), the Ue of 9.7 J cm−3 at 2628 kV cm−1 represented an increase of >400% (for pure PI Ue = 1.9 J cm−3 at 3251 kV cm−1) [5].
Recently, much work has focused on introducing an intermediate layer or an insulating shell on the surface of the filler to prevent them from directly connecting to each other. Fillers in composite materials can increase electrical conductivity and cause excessive polarization interfaces. Researchers are also attempting to introduce intermediate layers or oxide shells between fillers to reduce dielectric loss. Studies have also shown that the core-shell structure can achieve a high εr, low dielectric loss, and high energy density [28, 33].
Liu et al. [34] synthesized a sandwich-shaped core-shell SiO2@GO hybrid to prepare a novel SiO2@GO/PI flexible composite film using in situ polymerization. The dense SiO2 layer grafted onto the GO surface can effectively suppress leakage current. The results showed that at 40 Hz, the εr of the composite material containing 20 wt% SiO2@GO was as high as 73, which was 21 times that of pure PI (3.0), and the dielectric loss was only 0.39. In order to improve interfacial compatibility, two coupling agents, 3-aminopropyl triethoxysilane and 3-glycidoxypropyltrimethoxysilane (GPTS), were used to modify the surface of SiO2@GO: At 40 Hz, the εr of the GPTS-SiO2@GO/PI composite increased to 79 and the loss decreased to 0.25. This significant improvement in the dielectric properties was due to the improved dispersibility of the filler following GPTS modification. Wang et al. [28] prepared a core-shell structure of BT@SiO2 nanofibers by electrospinning, and successfully prepared a nanocomposite membrane composed of core-shell BT@SiO2 nanofibers and PI. Because SiO2 has very low dielectric loss (0.00002) and moderate εr, using a thin layer of SiO2 to isolate PI from BT nanofibers can alleviate the local field concentration. The latter is caused by the large difference in εr between the concentrations of the two phases, thereby enhancing the breakdown strength of the PI nanocomposite film. Compared with pure PI, the composite film filled with 3 vol% BT@SiO2 nanofibers had a maximum Ue of 2.31 J cm−3 at 346 kV mm−1 (pure PI
(a) TEM image of core-shell structured AgNW. (b) TEM image of an individual AgNW. (c) SEM image of core-shell structured AgNW. (d) SEM image of AgNW/PI hybrid film [
Weng et al. [33] synthesized a novel core-shell of Ag@Al2O3 nanoparticles as conductive fillers and doped them into PI to prepare Ag@Al2O3/PI composite films. The composite film containing 10% by weight of Ag@Al2O3 had a εr of 21, which was seven times higher than that of pure PI (3.1). This increase in εr may be due to the high electrical conductivity of the Ag@Al2O3 filler, which caused interfacial polarization inside the composite in the applied electric field. Hence, when the mass fraction of Ag@Al2O3 was increased to 30%, the maximum value of εr was 124 [33].
Most polymer nanocomposites are expected to achieve high energy density by combining the high breakdown strength of the polymer matrix with the high εr of the filler. In fact, when the filler is introduced into the polymer matrix, the breakdown strength often decreases, especially when the volume fraction of the composite filler is high, which does not improve the energy density of the nanocomposite. Therefore, there is a need to expand nanocomposites into multilayer structures to compensate for the reduced breakdown strength [36].
Chen et al. [36] designed a three-layer PI composite membrane by combining KTa0.5Nb0.5O3 (KTN) nanoparticles with PI. Pure PI (with high breakdown field strength) was used as the middle layer with KTN/PI nanocomposite as the two outer layers to improve the energy storage performance of the entire composite film. The results showed that the maximum discharge energy density of the triple-layer composite film (t-KPI) was 3.0 J cm−3 at 300 kV mm−1, which was much larger than the maximum discharge energy density of the equivalent single-layer composite film (1.5 J cm−3, at 210 kV mm−1); at a high electric field of 300 kV mm−1, the t-KPI composite film could still maintain 88% charge and discharge efficiency [36]. Amin Azizi et al. [37] prepared large-scale high-quality hexagonal boron nitride (h-BN) films using vapor deposition technology (CVD) and transferred them to PEI films to synthesize h-BN/PEI/h-BN composite film. As shown in Figure 11, this composite film exhibits excellent charge-discharge efficiency and dielectric stability at high temperatures. At 100°C, the discharge energy density of h-BN-coated PEI reached 2.93 J cm−3, and its charge-discharge efficiency was >90%. As the operating temperature increased, its advantages become more obvious. At 200°C, the energy density of h-BN-coated PEI film was 1.19 J cm−3. Rapid cyclic discharge experiments were performed at 150°C and 200 MV m−1 to test the stability of h-BN/PEI/h-BN composite films under electric fields and high temperature. The results demonstrated that the h-BN/PEI/h-BN film coated with 19 layers of h-BN did not show any reduction in discharge energy density and charge-discharge efficiency over 55,000 charge-discharge cycles [37].
Charge-discharge efficiency of the dielectrics as a function of temperatures measured at an applied field of (a) 200, (b) 300, and (c) 400 MVm−1. (d) Discharged energy density achieved at above 90% charge-discharge efficiency at varied temperatures [
Chen et al. [38] prepared an amino-modified CNT/PI (NH2-MWCNT/PI) flexible composite film with a three-layer structure in which a high-dielectric NH2-MWCNT was inserted between pure PI layers (serving as the bottom and top layers) of the complex. Since the conductive paths of the insulating layer could be effectively isolated, the three-layer composite film showed high εr and low dielectric loss. It is worth noting that at 1 kHz, when the NH2-MWCNT content of the intermediate layer was 10 wt%, the multilayer composite film (P-10-P) gave the highest εr of 31.3, while the dielectric loss was 0.0016. In addition, the maximum energy density of the composite membrane containing 5 wt% NH2-MWCNT in the intermediate layer (P-5-P) was as high as 1.95 J cm−3, which is more than 50% higher than that of pure PI (1.41 J cm−3). The maximum energy density of the composite film P-10-P also remained at 1.31 J cm−3 [38]. Among the various films, h-BN/PI composite film filled with 5 vol% h-BN as the outer layer could improve the heat dissipation ability of the three-layer composite material, thereby maintaining the dielectric strength and suppressing leakage current at high temperatures. Hence, this sandwich structure composite material had excellent energy storage properties and high temperature stability. At 25 and 150°C, the maximum field strengths of the composite film with a Zr and Ca modified BT (BZT-BCT) content of 1 vol% in the intermediate layer were 360 and 350 kV mm−1 respectively, while the storage densities were 2.3 and 1.83 J cm−3, respectively [39]. Zhou et al. [40] proposed a method for preparing high-performance polymer dielectrics at high temperatures (designed roll-to-roll plasma enhanced CVD), which was easily adapted to large-scale production of various surface-functionalized polymer films. In this experiment, they uniformly deposited wide-band gap SiO2 on the dielectric polymer film at ambient temperature and atmospheric pressure, and their productivity was comparable to that of melt extrusion. The results showed that the introduced SiO2 layer increased the potential barrier at the electrode/dielectric interface, resulting in a significant decrease in conductivity. Therefore, compared with the pure polymer (see Figure 12), the SiO2-coated film exhibited good high-temperature capacitance performance and had a higher energy storage efficiency (η) value. For example, at 150°C, when η > 90%, the maximum Ue values of PEI-SiO2, PEN-SiO2, PI-SiO2, PC-SiO2, and FPE-SiO2 composite films were 2.12, 1.75, 1.24, 1.79, and 2.06 J cm−3, which were respectively 236, 672, 510, 1279, and 644% greater than the corresponding pure films. At 100°C, when η > 90%, Ue for PEI-SiO2 was 3.0 J cm−3 [40].
(a) Charge-discharge efficiency and discharged energy density of BOPP and BOPP-SiO2 films with 180 nm coating layer on each side of the polymer measured at 120°C. (b) Charge-discharge efficiency of the various dielectric films before and after coating measured at 150°C. (c) Maximum discharged energy density of the various dielectric films before and after coating achieved at above 90% charge-discharge efficiency measured at 150°C. (d) Discharged energy density obtained from cyclic fast discharge tests of pristine BOPP and BOPP-SiO2 films [
In conclusion, the high-temperature polyimide dielectric materials used in energy storage application have been summarized, including pure PI, structure modification of PI, PI-based nanocomposites, etc. Many methods for micro molecule dimension and macrostructure design have been analyzed. The reviewed research studies encompassed commercial products progress, material design, and specification, the fundamental theory such as dielectric properties, energy density, and thermal properties. However, the current research for available high-temperature dielectric materials still falls short of industrial application, especially operating under extreme environment conditions, due to the relatively low dielectric permittivity and higher dielectric loss, which severely limit the energy storage density. Moreover, the thermal conductivity is also a limiting factor for high-temperature polymer dielectric materials. Therefore, more fundamental research on developing high-performance intrinsic polymer and high-temperature dielectric phenomena should be focused for future application.
This work was financially supported by National Nature Science Foundation of China (No. 51977114).
The authors declare no conflict of interest.
Similarly to many areas of private life and business, increasing numbers of processes, results, and discussions in science are shifting to the digital sphere. For example, the scientific output is shared and discussed in established social media such as Twitter and Facebook. In addition, platforms created specifically for scientists, such as Academia.edu, ResearchGate, or Mendeley [1, 2], are also growing in numbers. The “Science 2.0” [3] era is progressing and this simultaneously increases the demand for indicators capable of measuring web-based impact. A pure consideration of the citation numbers from classical bibliometrics appears outdated since they reflect only a limited picture of the impact of scientific publications [4].
To date, web-based impact in social media has been measured mainly by the number of downloads or clicks, or by using indicators created by the operators themselves, such as ResearchGate’s (RG) score [5]. These web-based metrics get the umbrella term “alternative metrics,” or “altmetrics” [6]. Collecting and analyzing altmetrics is gaining relevance, and not only in science. Political decision makers, too, are attaching corresponding importance to the issue. Thus, the German Federal Ministry of Education and Research (BMBF), for example, has launched the first study evaluating the possibilities and limitations of using altmetrics for impact measurements [7]. Furthermore, BMBF has initiated a funding line for quantitative science research, in which the further investigation of altmetrics plays a central role.
The present chapter gives an overview of the current stance of scientometric research on alt-metrics. We show example metrics and discuss what conclusions can be drawn from them. It will become apparent that altmetrics do not meet the expectation of measuring scientific impact because the data are too heterogeneous, their interpretation has not yet been sufficiently clarified, and an indicator system with meaningful and reliable benchmarks does not yet exist. Furthermore, we will investigate what strategies scientific institutions can pursue in using altmetrics and provide information on prospects for success.
The introduction of alternative indicators for the quantification of scientific output and the associated resonance on the Internet can be traced back to a discussion by Priem et al. in 2010 [6]. They questioned whether focusing on the classical bibliometric indicators adequately reflects the scientific and social significance of research in the era of the Internet. During the course of this discussion, the expression “altmetrics” was coined as a collective term for alternative metrics, which include web-based information on scientific publications. Therefore, altmetrics can be regarded as a complement to classical bibliometric indicators providing new information that was previously unavailable, predominantly from the social media sector. This new information makes it possible to examine the reception of scientific publications, for example, on news sites, in science blogs, policy papers, and other web-based sources.
The altmetrics community can now look back on almost 7 years of research. On the one hand, the “visibility and presence of altmetrics are quite impressive” [8] because they are used as marketing tools by many scientific publishers, more than 300 publications on the subject have appeared, and there are even conferences dedicated solely to altmetrics. On the other hand, there is no uniform definition, and therefore no consensus on what exactly is measured by altmetrics and what conclusions can be drawn from the results [8, 9, 10]. The only consensus regarding the term definition is that the indicators discussed are intended to measure the attention paid to scientific output where bibliometrics reaches its limits—that is, on the Internet [6]. There is, however, a lack of any further and more detailed differentiation of such metrics.
Due to the fact that the base communities are the same, there is a certain tension between altmetrics and bibliometrics. Both (sub-)disciplines are intended to fulfill the same purpose, to generate a picture of scientific impact, but based on different influencing factors. Almost like a reflex, the two fields are often set in relation to each other, compared, or set up as an either/or selection.
In contrast, within the community itself, there is a general consensus that both disciplines complement each other instead of one excluding the other [11]. Altmetrics are not intended to replace the peer review process or bibliometrics; rather, they should be viewed as a second opinion [10] and a “new perspective on communication by and about science in social media” [7]. A report by the expert group on altmetrics on behalf of the European commission also argues for classical bibliometrics that they “offer complementary approaches to evaluation” together with alternative metrics [12]. The expert group furthermore sees potentials for including a wider audience beyond the closed science system and for collecting information considerably faster than with conventional metrics. Furthermore, the idea of this approach is not limited to conventional scientific publication formats but offers the perspective of making data sources such as software and data sets accessible (e.g., as part of research data management).
The big difference between bibliometrics and altmetrics is the aspect that scientific publications are the traditional and indispensable main output of science. Thus, bibliometrics measures something that is at the center of the scientific reward system. The communication of science to society—that is, what is measured by altmetrics—is not part of the scientific reward system as yet. Creating incentives and expanding this reward system at this point would likely lead to increased use of social media by science and thus also strengthen altmetrics.
With regard to the practical application of altmetrics in research policy, science evaluations, and management, the scientific community is mostly skeptical. Bornmann and Haunschild [13] stress the problematic nature of the matter, namely that altmetrics should first confirm with the Leiden Manifesto for research metrics [14] before being applied on a greater scale. The central difficulties associated with altmetrics are presented, namely that there are currently no standardized indicators, that altmetric data are for the most part not accessible in a transparent and open manner, and that numbers can be manipulated through “gaming.” Gaming is a term for the targeted manipulation of data for the purposes of achieving better altmetric values. Such gaming activities are negative side effects of an orientation along user statistics in evaluation practice [9]. However, in spite of the difficulty in consistently unambiguously distinguishing gaming from marketing, altmetrics service providers are trying to minimize such effects. For example, altmetric.com manually removes obvious manipulations of altmetric scores or limits them by means of spammer lists [15].
Gaming is also a problem beyond the sources assessed by altmetric service providers. In a study by Meier and Tunger, it became apparent that it is possible to considerably influence the metrics specially developed by the ResearchGate platform, the RG score [16]. The RG score is intended to measure the “scientific reputation” of ResearchGate users. It is influenced by the impact of a user’s own scientific publications but also by their social activities on the platform (see https://www.researchgate.net/RGScore/FAQ). Meier and Tunger found that it is possible within a relatively short time to achieve an RG score that is higher that the RG scores of half of all RG users solely by gaming without any scientific publications.
In another study for the European commission, Kim Holmberg found that altmetrics are not yet practically applied in the EU for the purposes of scientific evaluation. In his view, such practice on a wide scale would be premature as long as what altmetrics actually measure remains unclear [17].
A semantic analysis of contributions in social media is lacking for the most part, which is a major issue making the evaluation of altmetrics counts so difficult. References are mostly counted based on identifiers such as the DOI; however, which references should be evaluated as positive and which as negative cannot be handled, which means that a “performance paradox” develops [18]. This paradox also exists in a similar form in classical bibliometrics and must be considered as an inherent problem of quantitative metrics in use [19].
Furthermore, the coverage of scientific publications is relatively low and the distribution varies heavily both across disciplines and across platforms. Haustein et al. found that 21.5% of all scientific publications in Web of Science in 2012 were mentioned in at least one Tweet, while the proportion of these publications in other social media was mentioned less than 5% [20]. In percentage comparison, 67% of the publications were cited in Web of Science at least once. A feasibility study conducted by BMBF shows strong variation concerning coverage on altmetric.com between the scientific disciplines: publications from the field of medicine are represented considerably more often than, for example, publications from the engineering sciences [7]. Differences in coverage appear to benefit the humanities sciences in particular. While these are scarcely considered in established databases such as Web of Science, their coverage is considerably better in the field of altmetrics, according to a study conducted by Hammarfelt: over 61% of the investigated publications in this field have at least one reader on Mendeley and more than 20% have already been discussed on Twitter [21].
In general, the data basis underlying altmetrics is often problematic: the reproduction of data is almost impossible because data providers change, modify their data stock, or disappear completely [4]. For example, platforms such as Weibo or LinkedIn, which are included in the sources covered by altmetric.com, are now no longer analyzed since these data providers no longer grant access. Quality control, such as a validity check of accounts or the clean-up of duplicates, rarely occurs for social media platforms and complicates the aggregating and filtering of data for altmetrics service providers [22].
Furthermore, Fraumann et al. ascertained that duplicates can be found in several types of sources on altmetric.com, which makes the credibility of the attention score uncertain [23]. This attention score is currently used by many scientific publishers and institutions as a marketing tool in the form of the “Altmetric Donut” (see Figure 1). The Altmetric Donut is implemented on the websites of the journals
Example of the representation of the Altmetric Donut and its composition.
To date, the European Commission ascribes high significance to altmetrics, particularly against the backdrop of open science. This is also reflected in the establishment of the associated expert group. The efforts have so far led to a compilation of twelve recommendations within the open science context. In the political context of the European Union’s supranational level, the importance of guidelines for the conscientious application of metrics is emphasized. These guidelines are interlaced in the following with the demands from the Leiden Manifesto for research metrics.
The Leiden manifesto emphasizes the aspect of complementarity as a central principle and basis of any evaluation practice. According to it, for the existing qualitative practices, the aim should be to complement each other in an advantageous manner. Peer review and expert assessment—this is the ambition—could be reinforced by the appropriate use of quantitative metrics, and further aspects beyond the traditional science system could be illuminated: “quantitative evaluation should support qualitative, expert assessment” [14].
Another aspect is the openness and transparency of all steps in the analysis process: “keep data collection and analytical processes open, transparent and simple” [14], that is, analyses should be verifiable and the indicators should not be unnecessarily complicated. At the same time, this does not mean that simple indicators (e.g., pure absolute numbers) with no significance should be used instead.
This recommendation is particularly important against the backdrop of the altmetric attention score since this composite indicator always combines data from many different sources. Their individual significance is unknown so that the score value can only contribute rudimentary information on the visibility of a publication in social media and therefore not be used for evaluation. At this point, attention should also be drawn to the inappropriate use of the journal impact factor, which occurs in a cumulative form particularly in medical science: its incorrect use as a citation indicator instead of as a simple journal indicator shows that it is immensely difficult to eliminate a metric once it has been established. Metrics in the scientific context must be reliable, reproducible, and significant.
To what extent altmetrics will establish themselves in research policy depends fundamentally on empirical values from practical application in the sense of a learning experimental system. Therefore, potential fields of application are briefly outlined in the following paragraphs.
Due to the explorative development stage of altmetrics (as described above), they must be used carefully with regard to their application in the performance assessment of institutions and single scientists, for example within the scope of scientific evaluation. In particular, there is a lack of studies investigating how valid and reliable the evaluation of science based on altmetrics is. In the scientific discourse, a deeper understanding of the heterogeneity and the significance of the data must be achieved. In addition, useful indicators must be developed and benchmarking studies have to be conducted. According to current opinion, altmetrics will in the near future be more of a complementary component rather than an independent indicator for the assessment of scientific performance.
In addition, some research topics are more in the focus of society than others without necessarily displaying a larger social impact. In this context, attention should be drawn to the news values theory: it describes factors why some topics are reasonably sure to be reported and some are unlikely to become objects of journalistic reports in mass media [25]. Against this backdrop, altmetrics can be viewed as an incomplete indicator for social visibility. To what extent this circumstance will change over time cannot currently be predicted and depends more on the social discourse on science and the opening of the science system than on further methodological developments.
A part of communication on science and its visibility in the public sphere is represented by altmetrics. In any case, it should be noted that there is a rising trend in social media activity measured by the frequency of contributions and the number of people involved. Thus, it is becoming increasingly important to use social media platforms in order to proactively draw attention to research, that is, advertise it.
As an example in this context, institutional efforts such as those undertaken by universities or the European Commission, can be observed, which strategically position their own publications and activities. Against the backdrop of the explorative state of these efforts, altmetrics could serve as feedback, for example, to test various approaches aimed at new target groups in society. With regard to research policy, particularly activities with a strong social relevance and their visibility could represent an interesting field of application complementing current evaluation approaches for analyzing media feedback. Initial network analyses are already delivering promising results and their application to research policy issues could be examined. Using specific issues associated with communication propagation, attention could be focused, for example, on the identification of relevant multipliers—for example, science journalists and representatives from politics, industry, and interest groups—in the dissemination of information. Identifying such mechanisms and transmission channels in pilot studies would be promising research priorities in this respect in addition to medial feedback already addressed through established investigation designs.
Publishers already use the altmetric score mentioned in Section 3 as feedback on articles, albeit in a strongly aggregated and simplified form. Similar efforts are also apparent at universities and research institutions, which are testing the implementation of the Altmetric Donut both with and without the score, although the added value of these efforts has yet to be clarified. As part of a pilot measure, the OECD is currently investigating to what extent the altmetric explorer and the implementation of the altmetric score are suited to determine the social range of policy documents.
Science institutions can also use altmetrics within the scope of science marketing: it is conceivable that altmetrics could be used to focus attention on those publications by an institution that is widely discussed, shared, tweeted, or used in news pieces. This would permit the interface between science and society to be better addressed.
Whether there is any benefit from altmetrics in economics or politics beyond science has not yet been verified. From our viewpoint, there would be benefits if more sources of economic or policy-relevant sources were covered by the altmetrics databases. In this case, it would be possible to regard or measure the contribution of science in economy or policy. With bibliometric instruments, such as publication or citation analyses, it is not possible to measure this contribution since the economic or political world does not publish articles in scientific outlets. With altmetrics one would be able to have a look at, for example, mentions of scientific publications in documents, which influence politics or discussions on the application of scientific research in economics or companies. Generally, it would be worthwhile to identify the impact of scientific contributions on individual groups more easily, if one could associate contributions on social media platforms to particular fields of application.
For scientists, the visibility of their publications is essential. The reputation resulting from the use by others of their scientific output in the form of ideas, statements, calculations, and findings is an essential part of the science system. Only the use of the generated output creates sustainable value for an individual scientist, be it in other scientific publications or in web-based communication, social media, or news pieces. Bibliometrics and altmetrics help scientists document the visibility of their work. Thus, the majority of the almost 700 scientists who participated in a survey on the RG platform stated that it is important to them to have a high RG score.
Altmetrics permit scientists to record, regulate, and document their own visibility to a greater extent than was previously possible. Particularly for early-career scientists, there is thus a great opportunity to increase attention and reputation independently from the traditional publication system. In the longer term, altmetrics could assume the function of documenting the mediation of science to society and of making it more transparent.
Academic libraries are usually where contacts can be found within a scientific institution for issues related to publication data and bibliometric processes/indicators. Librarians’ clean data, compile publication profiles, and collect data within the scope of evaluations. They are thus specialists for handling data, particularly data related to publications, user statistics, and stock management.
This is where altmetrics represent a connecting element as they illuminate the use of publications in social media. Thus it is plausible for libraries to be directly involved whenever the issue of altmetrics is addressed at an institution. This makes sense because librarians are in contact with many areas of a scientific institution and offer advice on using information products. Roemer and Borchardt [26] identified this central role of libraries and summarize: “[…] librarians serve as natural leaders when it comes to altmetrics […]” [26]. They argue that this is due to the resources and data knowledge of libraries as well as their central position as contact partners for various target groups [27, 28].
In conclusion, altmetrics are currently still at an explorative stage and have far to go before they can make a regular contribution to quantitative science indicators of bibliometrics [29]. We show that there are still problems with the indicators and associated benchmarks. This is why the use of altmetrics in the context of science evaluations is not yet conceivable. Simultaneously, however, this insight could function as an incentive to enhance application maturity and to create the political boundary conditions for advancing further developments. Thanks to initial applications of altmetrics in the academic context, important experience is being gained. The scientific debate over the past few years has thus led to altmetrics achieving the validity and application maturity required for initial applications. However, they must be further developed for applications that are more thorough; particular indicators have to go beyond the level of individual publications and should also aggregate data on various levels. Additionally, the problems of altmetric indicators have to be addressed especially regarding coverage, representativeness, gaming, and validity.
Interviews of the bibliometrics team at Forschungszentrum Jülich with experts in the field of bibliometrics and altmetrics confirm the above-mentioned findings [7]. These experts gave statements about the meaningfulness and application maturity of altmetrics. They stated that the significance of altmetrics indicators is located at a low to medium range only. The initial euphoria in the field, with the focus on the far-reaching potentials up to the measurement of the social impact and the performance evaluation of science, seems to have subsided.
There was a consensus between the experts that altmetrics is not an alternative to bibliometrics, but a new perspective on communication from and about science in social media: Perception and “popularity” are in the foreground. However, scientific quality or excellence is marginally represented by altmetrics, since it correlates only partially positively with perception. In principle, this contradicts bibliometrics, which is based on an inherent and peer review-based approach for the evaluation of science.
In contrast to the meaningfulness, the experts’ assessments differ more strongly with regard to the maturity for application of altmetrics. This is sometimes due to the fact that expectations diverge: should these metrics be a purely quantitative indicator or do they provide the starting point for qualitative analyses? Furthermore, the areas of application are very broad and also include marketing activities that have so far been of secondary importance for research policy. Against this background, there is still unanimity that altmetrics can currently not be interpreted as a standalone and quantitative indicator. In particular, it was unanimously emphasized that altmetrics does not conform to a scientific database that is a prerequisite for the assessment of scientific work.
The appreciation of what role policymakers should play and how altmetrics can be used for research policy are divergent. However, in most of the interviews, the experts think that politicians should play an active role in shaping the implementation of altmetrics. Politicians could create a superordinate and binding framework for the application of altmetrics, for instance, by anchoring demands and formulating research questions.
In the long term, the increasing involvement of science in social media platforms will have a positive effect on the application of altmetrics. In addition, data providers are designing sources systematically and increasingly semantically. Current developments appear promising and point toward an expansion of source selection for English-language policy documents and news articles [15]. This would mean that in addition to the relevant news target groups, two complementary transmission channels of science into politics and industry can be covered.
IntechOpen implements a robust policy to minimize and deal with instances of fraud or misconduct. As part of our general commitment to transparency and openness, and in order to maintain high scientific standards, we have a well-defined editorial policy regarding Retractions and Corrections.
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\\n\\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
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\\n\\n3.1. ERRATUM
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\\n\\n3.2. CORRIGENDUM
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\\n\\n4. FINAL REMARKS
\\n\\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\\n\\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\\n\\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
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\\n\\nPolicy last updated: 2017-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
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\n\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
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\n\n1.2. REMOVALS AND CANCELLATIONS
\n\n2. STATEMENTS OF CONCERN
\n\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\n\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\n\n3. CORRECTIONS
\n\nA Correction will be issued by the Academic Editor when:
\n\n3.1. ERRATUM
\n\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\n\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n3.2. CORRIGENDUM
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\n\n4. FINAL REMARKS
\n\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\n\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\n\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\n\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\n\nPolicy last updated: 2017-09-11
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More so, the mechanism by which heavy metals cause neurotoxicity, generate free radical which promotes oxidative stress damaging lipids, proteins and DNA molecules and how these free radicals propagate carcinogenesis are discussed. Alongside these mechanisms, the noxious health effects of these heavy metals are discussed.",book:{id:"7111",slug:"poisoning-in-the-modern-world-new-tricks-for-an-old-dog-",title:"Poisoning in the Modern World",fullTitle:"Poisoning in the Modern World - New Tricks for an Old Dog?"},signatures:"Godwill Azeh Engwa, Paschaline Udoka Ferdinand, Friday Nweke Nwalo and Marian N. 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In vitro, chemicals such as drugs and pesticides have different cytotoxicity mechanisms such as destruction of cell membranes, prevention of protein synthesis, irreversible binding to receptors etc. In order to determine the cell death caused by these damages, there is a need for cheap, reliable and reproducible short-term cytotoxicity and cell viability assays. Cytotoxicity and cell viability assays are based on various cell functions. A broad spectrum of cytotoxicity assays is currently used in the fields of toxicology and pharmacology. There are different classifications for these assays: (i) dye exclusion assays; (ii) colorimetric assays; (iii) fluorometric assays; and (iv) luminometric assays. Choosing the appropriate method among these assays is important for obtaining accurate and reliable results. When selecting the cytotoxicity and cell viability assays to be used in the study, different parameters have to be considered such as the availability in the laboratory where the study is to be performed, test compounds, detection mechanism, specificity, and sensitivity. In this chapter, information will be given about in vitro cytotoxicity and viability assays, these assays will be classified and their advantages and disadvantages will be emphasized. The aim of this chapter is to guide the researcher interested in this subject to select the appropriate assay for their study.",book:{id:"6310",slug:"genotoxicity-a-predictable-risk-to-our-actual-world",title:"Genotoxicity",fullTitle:"Genotoxicity - A Predictable Risk to Our Actual World"},signatures:"Özlem Sultan Aslantürk",authors:[{id:"211212",title:"Dr.",name:"Özlem Sultan",middleName:null,surname:"Aslantürk",slug:"ozlem-sultan-aslanturk",fullName:"Özlem Sultan Aslantürk"}]},{id:"66259",doi:"10.5772/intechopen.85270",title:"Antioxidant Compounds and Their Antioxidant Mechanism",slug:"antioxidant-compounds-and-their-antioxidant-mechanism",totalDownloads:7369,totalCrossrefCites:48,totalDimensionsCites:123,abstract:"An antioxidant is a substance that at low concentrations delays or prevents oxidation of a substrate. Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. The importance of antioxidant mechanisms is to understand the biological meaning of antioxidants, their possible uses, their production by organic synthesis or biotechnological methods, or for the standardization of the determination of antioxidant activity. In general, antioxidant molecules can react either by multiple mechanisms or by a predominant mechanism. The chemical structure of the antioxidant substance allows understanding of the antioxidant reaction mechanism. This chapter reviews the in vitro antioxidant reaction mechanisms of organic compounds polyphenols, carotenoids, and vitamins C against free radicals (FR) and prooxidant compounds under diverse conditions, as well as the most commonly used methods to evaluate the antioxidant activity of these compounds according to the mechanism involved in the reaction with free radicals and the methods of in vitro antioxidant evaluation that are used frequently depending on the reaction mechanism of the antioxidant.",book:{id:"8008",slug:"antioxidants",title:"Antioxidants",fullTitle:"Antioxidants"},signatures:"Norma Francenia Santos-Sánchez, Raúl Salas-Coronado, Claudia Villanueva-Cañongo and Beatriz Hernández-Carlos",authors:[{id:"143354",title:"Dr.",name:"Raúl",middleName:null,surname:"Salas-Coronado",slug:"raul-salas-coronado",fullName:"Raúl Salas-Coronado"},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez"},{id:"193718",title:"Dr.",name:"Beatriz",middleName:null,surname:"Hernández-Carlos",slug:"beatriz-hernandez-carlos",fullName:"Beatriz Hernández-Carlos"},{id:"278133",title:"Dr.",name:"Claudia",middleName:null,surname:"Villanueva-Cañongo",slug:"claudia-villanueva-canongo",fullName:"Claudia Villanueva-Cañongo"}]},{id:"40253",doi:"10.5772/50486",title:"Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development",slug:"lipid-nanoparticulate-drug-delivery-systems-a-revolution-in-dosage-form-design-and-development",totalDownloads:11196,totalCrossrefCites:20,totalDimensionsCites:100,abstract:null,book:{id:"2509",slug:"recent-advances-in-novel-drug-carrier-systems",title:"Recent Advances in Novel Drug Carrier Systems",fullTitle:"Recent Advances in Novel Drug Carrier Systems"},signatures:"Anthony A. Attama, Mumuni A. Momoh and Philip F. Builders",authors:[{id:"142947",title:"Prof.",name:"Anthony",middleName:null,surname:"Attama",slug:"anthony-attama",fullName:"Anthony Attama"}]},{id:"42016",doi:"10.5772/55187",title:"Why are Early Life Stages of Aquatic Organisms more Sensitive to Toxicants than Adults?",slug:"why-are-early-life-stages-of-aquatic-organisms-more-sensitive-to-toxicants-than-adults-",totalDownloads:3460,totalCrossrefCites:35,totalDimensionsCites:97,abstract:null,book:{id:"3408",slug:"new-insights-into-toxicity-and-drug-testing",title:"New Insights into Toxicity and Drug Testing",fullTitle:"New Insights into Toxicity and Drug Testing"},signatures:"Azad Mohammed",authors:[{id:"147061",title:"Dr.",name:"Azad",middleName:null,surname:"Mohammed",slug:"azad-mohammed",fullName:"Azad Mohammed"}]}],mostDownloadedChaptersLast30Days:[{id:"64762",title:"Mechanism and Health Effects of Heavy Metal Toxicity in Humans",slug:"mechanism-and-health-effects-of-heavy-metal-toxicity-in-humans",totalDownloads:10088,totalCrossrefCites:90,totalDimensionsCites:209,abstract:"Several heavy metals are found naturally in the earth crust and are exploited for various industrial and economic purposes. Among these heavy metals, a few have direct or indirect impact on the human body. Some of these heavy metals such as copper, cobalt, iron, nickel, magnesium, molybdenum, chromium, selenium, manganese and zinc have functional roles which are essential for various diverse physiological and biochemical activities in the body. However, some of these heavy metals in high doses can be harmful to the body while others such as cadmium, mercury, lead, chromium, silver, and arsenic in minute quantities have delirious effects in the body causing acute and chronic toxicities in humans. The focus of this chapter is to describe the various mechanism of intoxication of some selected heavy metals in humans along with their health effects. Therefore it aims to highlight on biochemical mechanisms of heavy metal intoxication which involves binding to proteins and enzymes, altering their activity and causing damage. More so, the mechanism by which heavy metals cause neurotoxicity, generate free radical which promotes oxidative stress damaging lipids, proteins and DNA molecules and how these free radicals propagate carcinogenesis are discussed. Alongside these mechanisms, the noxious health effects of these heavy metals are discussed.",book:{id:"7111",slug:"poisoning-in-the-modern-world-new-tricks-for-an-old-dog-",title:"Poisoning in the Modern World",fullTitle:"Poisoning in the Modern World - New Tricks for an Old Dog?"},signatures:"Godwill Azeh Engwa, Paschaline Udoka Ferdinand, Friday Nweke Nwalo and Marian N. Unachukwu",authors:[{id:"241837",title:"Mr.",name:"Godwill Azeh",middleName:null,surname:"Engwa",slug:"godwill-azeh-engwa",fullName:"Godwill Azeh Engwa"},{id:"274194",title:"BSc.",name:"Paschaline Ferdinand",middleName:null,surname:"Okeke",slug:"paschaline-ferdinand-okeke",fullName:"Paschaline Ferdinand Okeke"},{id:"286975",title:"Dr.",name:"Friday",middleName:null,surname:"Nweke Nwalo",slug:"friday-nweke-nwalo",fullName:"Friday Nweke Nwalo"},{id:"286976",title:"Dr.",name:"Marian",middleName:null,surname:"Unachukwu",slug:"marian-unachukwu",fullName:"Marian Unachukwu"}]},{id:"49459",title:"Pharmacokinetics of Drugs Following IV Bolus, IV Infusion, and Oral Administration",slug:"pharmacokinetics-of-drugs-following-iv-bolus-iv-infusion-and-oral-administration",totalDownloads:15301,totalCrossrefCites:15,totalDimensionsCites:22,abstract:null,book:{id:"4491",slug:"basic-pharmacokinetic-concepts-and-some-clinical-applications",title:"Basic Pharmacokinetic Concepts and Some Clinical Applications",fullTitle:"Basic Pharmacokinetic Concepts and Some Clinical Applications"},signatures:"Tarek A. Ahmed",authors:[{id:"175649",title:"Dr.",name:"Tarek A",middleName:null,surname:"Ahmed",slug:"tarek-a-ahmed",fullName:"Tarek A Ahmed"}]},{id:"29240",title:"Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability",slug:"oral-absorption-intestinal-metabolism-and-human-oral-bioavailability-",totalDownloads:26951,totalCrossrefCites:24,totalDimensionsCites:55,abstract:null,book:{id:"672",slug:"topics-on-drug-metabolism",title:"Topics on Drug Metabolism",fullTitle:"Topics on Drug Metabolism"},signatures:"Ayman El-Kattan and Manthena Varma",authors:[{id:"85539",title:"Dr.",name:"Ayman",middleName:null,surname:"El-Kattan",slug:"ayman-el-kattan",fullName:"Ayman El-Kattan"},{id:"88221",title:"Dr.",name:"Manthena",middleName:null,surname:"Varma",slug:"manthena-varma",fullName:"Manthena Varma"}]},{id:"66259",title:"Antioxidant Compounds and Their Antioxidant Mechanism",slug:"antioxidant-compounds-and-their-antioxidant-mechanism",totalDownloads:7378,totalCrossrefCites:49,totalDimensionsCites:123,abstract:"An antioxidant is a substance that at low concentrations delays or prevents oxidation of a substrate. Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. The importance of antioxidant mechanisms is to understand the biological meaning of antioxidants, their possible uses, their production by organic synthesis or biotechnological methods, or for the standardization of the determination of antioxidant activity. In general, antioxidant molecules can react either by multiple mechanisms or by a predominant mechanism. The chemical structure of the antioxidant substance allows understanding of the antioxidant reaction mechanism. This chapter reviews the in vitro antioxidant reaction mechanisms of organic compounds polyphenols, carotenoids, and vitamins C against free radicals (FR) and prooxidant compounds under diverse conditions, as well as the most commonly used methods to evaluate the antioxidant activity of these compounds according to the mechanism involved in the reaction with free radicals and the methods of in vitro antioxidant evaluation that are used frequently depending on the reaction mechanism of the antioxidant.",book:{id:"8008",slug:"antioxidants",title:"Antioxidants",fullTitle:"Antioxidants"},signatures:"Norma Francenia Santos-Sánchez, Raúl Salas-Coronado, Claudia Villanueva-Cañongo and Beatriz Hernández-Carlos",authors:[{id:"143354",title:"Dr.",name:"Raúl",middleName:null,surname:"Salas-Coronado",slug:"raul-salas-coronado",fullName:"Raúl Salas-Coronado"},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez"},{id:"193718",title:"Dr.",name:"Beatriz",middleName:null,surname:"Hernández-Carlos",slug:"beatriz-hernandez-carlos",fullName:"Beatriz Hernández-Carlos"},{id:"278133",title:"Dr.",name:"Claudia",middleName:null,surname:"Villanueva-Cañongo",slug:"claudia-villanueva-canongo",fullName:"Claudia Villanueva-Cañongo"}]},{id:"66742",title:"Introductory Chapter: Alkaloids - Their Importance in Nature and for Human Life",slug:"introductory-chapter-alkaloids-their-importance-in-nature-and-for-human-life",totalDownloads:3944,totalCrossrefCites:14,totalDimensionsCites:29,abstract:null,book:{id:"6828",slug:"alkaloids-their-importance-in-nature-and-human-life",title:"Alkaloids",fullTitle:"Alkaloids - Their Importance in Nature and Human Life"},signatures:"Joanna Kurek",authors:[{id:"214632",title:"Dr.",name:"Joanna",middleName:null,surname:"Kurek",slug:"joanna-kurek",fullName:"Joanna Kurek"}]}],onlineFirstChaptersFilter:{topicId:"19",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81739",title:"Machine Learning and Artificial Intelligence in Therapeutics and Drug Development Life Cycle",slug:"machine-learning-and-artificial-intelligence-in-therapeutics-and-drug-development-life-cycle",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.104753",abstract:"In recent years, the pharmaceutical business has seen a considerable increase in data digitization. With digitization, however, comes the challenge of obtaining, analyzing, and applying knowledge to solve complex clinical problems. Artificial intelligence (AI), which entails a variety of advanced tools and networks that can mimic human intellect, can overcome such challenges with traditional pharmaceutical development. Artificial intelligence and machine learning have a vast role in therapeutic development, including the prediction of drug target and properties of small molecules. By predicting the 3D protein structure, AI techniques, such as Alpha Fold, can help with structure-based drug development. Machine learning algorithms have been utilized to anticipate the properties of small molecules based on their chemical structure. Many researches have shown the importance of using in silico predictive ADMET (absorption, distribution, metabolism, excretion, and toxicity) models to speed up the discovery of small compounds with enhanced efficacy, safety, and dosage. This chapter discusses various roles of these methods in the development of effective therapeutics.",book:{id:"11091",title:"Drug Development Life Cycle",coverURL:"https://cdn.intechopen.com/books/images_new/11091.jpg"},signatures:"Subhomoi Borkotoky, Amit Joshi, Vikas Kaushik and Anupam Nath Jha"},{id:"81722",title:"Ketamine for Chronic Pain",slug:"ketamine-for-chronic-pain",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.104874",abstract:"The treatment of chronic pain is a chronic problem for many specialities. It is generally based on an approach with antidepressants, anti-epileptics and opioids as drugs of first choice. It has been worked by many different protocols. Ketamine, which is known as a good anaesthetic, has been used for chronic pain. When the pain has a neuropathic component, ketamine is a promising treatment for pain management. Ketamine: by inhibiting the N-methyl-D-aspartate receptor and having some other effects like enhancement of descending inhibition and anti-inflammatory effects at central sites, takes part in chronic pain management. Besides having analgesic effects, there are some concerns about the side effects of ketamine. Some psychedelic symptoms as hallucinations, memory defects, panic attacks, nausea and vomiting, somnolence, cardiovascular stimulation and sometimes hepatoxicity may be seen in patients. Ketamine is generally well-tolerated in clinical settings. Close monitoring of patients receiving ketamine should be mandatory in order to be aware of central nervous system, haemodynamic, renal and hepatic symptoms as well as abuse.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Cigdem Yildirim Guclu"},{id:"81715",title:"Clinical Relevance of Neutralizing Antibodies in Botulinum Neurotoxin Type A",slug:"clinical-relevance-of-neutralizing-antibodies-in-botulinum-neurotoxin-type-a",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.102896",abstract:"The precise definition of prevalence of neutralizing antibodies (NABs) affords cross-sectional testing of a cohort. But in most studies, only selected patients are tested. This leads to gross underestimation of NAB-prevalence, and the opinion that induction of NABs is a rare phenomenon in botulinum neurotoxin (BoNT)/A-therapy. However, recent cross-sectional studies report annual incidences between 1 and 2% in patients being treated with a complex protein (CP)-containing preparation. This implies that NAB-prevalence above 10% has to be expected in patients being treated for more than 10 years. High dose per session and long duration of treatment are relevant risk factors for induction of NABs. In patients exclusively treated with the CP-free incobotulinumtoxin A (incoBoNT/A) preparation Xeomin® no NAB-induction has been reported so far. In patients with NABs switching to incoBoNT/A may lead to a decline of NAB-titers. In patients with NABs under treatment with a CP-containing BoNT/A-preparation it may take years of treatment until a second treatment failure (STF) becomes clinical manifest. In a cohort of 59 patients with partial STF patients’ reports on the reduction of BoNT-activity predicted the presence of NABs better than treatment related data produced by the treating physicians.",book:{id:"11328",title:"Botulinum Toxin - Recent Topics and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg"},signatures:"Harald Hefter and Sara Samadzadeh"},{id:"81670",title:"Perspective Chapter: Repurposing Natural Products to Target COVID-19: Molecular Targets and New Avenues for Drug Discovery",slug:"perspective-chapter-repurposing-natural-products-to-target-covid-19-molecular-targets-and-new-avenue",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.103153",abstract:"World Health Organization (WHO) declared on March 11, 2020, coronavirus disease, which erupted in December 19th, 2019 in Wuhan, China (COVID-19) as worldwide pandemic disease. Researchers worldwide were successful to provide a prophylactic approach via developing several vaccines, which were swiftly approved by WHO under Emergency Use Listing (EUL) status. So far, lopinavir, chloroquine, azithromycin, hydroxychloroquine, favipiravir, umifenovir, ribavirin, remdesivir, and darunavir have been tested clinically. Hydroxychloroquine, favipiravir, and chloroquine exhibited a high ratio of distribution for the lung and were reported to minimize viral tonnage in respiratory system of many COVID-19 cases. However, none of the tested drugs showed a conclusive, safe, and efficient activity against COVID-19. This prompted many experts in drug discovery to fetch in the treasure of many available old drugs of natural origin to repurpose based upon their well-studied pharmacology, pharmacodynamics, virtual screening, and artificial intelligence studies. In this review chapter, we will address the repurposing of natural products and their derivatives to be used in treatment of COVID-19 via targeting host cells machinery and viral proteins either in early stages by blocking virus entry to cells or lately through inhibition of viral replication.",book:{id:"11088",title:"Antiviral Drugs",coverURL:"https://cdn.intechopen.com/books/images_new/11088.jpg"},signatures:"Farid A. Badria"},{id:"81561",title:"Ketamine and Low-Resource Countries",slug:"ketamine-and-low-resource-countries",totalDownloads:38,totalDimensionsCites:0,doi:"10.5772/intechopen.104651",abstract:"Safe anaesthesia and surgery are piloted to reduce the morbidity and mortality associated with anaesthesia and surgery, and improve surgical outcomes. This goal is far-fetched in developing countries as a result of limited manpower, poor operation theatre infrastructure, unavailability of equipment, life-saving drugs, and anaesthetic agents. Postoperative pain is also widely undertreated in this environment, mostly due to financial constraints patients and their relatives face and the unavailability of analgesics. Sometimes the physicians face problems associated with their resource-limited working environment, such as unreliable electricity, unavailability of compressed oxygen and other gases, sophisticated machines, and modern drugs. Thus, easy adaptability and proper utilisation of available resources have been described as a resounding quality required of anaesthetists working in developing countries, to thrive and provide anaesthetic services. Ketamine is readily available in resource-limited environments, and adaptability to the use of this drug has made it possible for the anaesthetist to provide anaesthesia, pain care services, sedation, and save lives.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Chimaobi Tim Nnaji"},{id:"81240",title:"Drug Delivery Applications of Metal-Organic Frameworks (MOFs)",slug:"drug-delivery-applications-of-metal-organic-frameworks-mofs",totalDownloads:25,totalDimensionsCites:0,doi:"10.5772/intechopen.103684",abstract:"There has been substantial progress in the field of metal–organic frameworks (MOFs) and their nanoscale counterparts (NMOFs), in recent years. Their exceptional physicochemical properties are being constantly and actively exploited for various applications such as energy harvesting, gas storage, gas separation, catalysis, etc. Due to their porous framework, large surface area, tunability and easy surface functionalization, MOFs and NMOFs have also emerged as useful tools for biomedical applications, specifically for drug delivery. As drug carriers, they offer high drug loading capacity and controlled release at the target site. This chapter aims to give a panorama of the use of these MOFs as drug delivery agents. A brief overview of the structure and composition of MOFs, along with various methods and techniques to synthesize NMOFs suitable for drug delivery applications are mentioned. In addition, the most commonly employed strategies to associate drugs with these NMOFs are highlighted and methods to characterize them are also briefly discussed. The last section summarizes the applications of MOFs and NMOFs as carriers of therapeutic drugs, biomolecules, and other active agents.",book:{id:"11319",title:"Drug Carriers",coverURL:"https://cdn.intechopen.com/books/images_new/11319.jpg"},signatures:"Ashi Mittal, Indrajit Roy and Sona Gandhi"}],onlineFirstChaptersTotal:77},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. 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Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Plant Physiology",value:13,count:1},{group:"subseries",caption:"Human Physiology",value:12,count:2},{group:"subseries",caption:"Cell Physiology",value:11,count:8}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1},{group:"publicationYear",caption:"2020",value:2020,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:302,paginationItems:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, Mexico. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/332882",hash:"",query:{},params:{id:"332882"},fullPath:"/profiles/332882",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()