Characteristics of representative corticosteroids [5].
Chapter 1: "Permanent Maxillary and Mandibular Incisors"\n
Chapter 2: "The Permanent Maxillary and Mandibular Premolar Teeth"\n
Chapter 3: "Dental Anatomical Features and Caries: A Relationship to be Investigated"\n
Chapter 4: "Anatomy Applied to Block Anaesthesia"\n
Chapter 5: "Treatment Considerations for Missing Teeth"\n
Chapter 6: "Anatomical and Functional Restoration of the Compromised Occlusion: From Theory to Materials"\n
Chapter 7: "Evaluation of the Anatomy of the Lower First Premolar"\n
Chapter 8: "A Comparative Study of the Validity and Reproducibility of Mesiodistal Tooth Size and Dental Arch with the iTero Intraoral Scanner and the Traditional Method"\n
Chapter 9: "Identification of Lower Central Incisors"\n
The book is aimed toward dentists and can also be well used in education and research.',isbn:"978-1-78923-511-1",printIsbn:"978-1-78923-510-4",pdfIsbn:"978-1-83881-247-8",doi:"10.5772/65542",price:119,priceEur:129,priceUsd:155,slug:"dental-anatomy",numberOfPages:204,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"445cd419d97f339f2b6514c742e6b050",bookSignature:"Bağdagül Helvacioğlu Kivanç",publishedDate:"August 1st 2018",coverURL:"https://cdn.intechopen.com/books/images_new/5814.jpg",numberOfDownloads:13239,numberOfWosCitations:0,numberOfCrossrefCitations:4,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:8,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:12,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 4th 2016",dateEndSecondStepPublish:"October 25th 2016",dateEndThirdStepPublish:"July 16th 2017",dateEndFourthStepPublish:"August 16th 2017",dateEndFifthStepPublish:"October 16th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"178570",title:"Dr.",name:"Bağdagül",middleName:null,surname:"Helvacıoğlu Kıvanç",slug:"bagdagul-helvacioglu-kivanc",fullName:"Bağdagül Helvacıoğlu Kıvanç",profilePictureURL:"https://mts.intechopen.com/storage/users/178570/images/7646_n.jpg",biography:"Bağdagül Helvacıoğlu Kıvanç is a dentist, a teacher, a researcher and a scientist in the field of Endodontics. She was born in Zonguldak, Turkey, on February 14, 1974; she is married and has two children. She graduated in 1997 from the Ankara University, Faculty of Dentistry, Ankara, Turkey. She aquired her PhD in 2004 from the Gazi University, Faculty of Dentistry, Department of Endodontics, Ankara, Turkey, and she is still an associate professor at the same department. She has published numerous articles and a book chapter in the areas of Operative Dentistry, Esthetic Dentistry and Endodontics. She is a member of Turkish Endodontic Society and European Endodontic Society.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"174",title:"Dentistry",slug:"dentistry"}],chapters:[{id:"56461",title:"Permanent Maxillary and Mandibular Incisors",doi:"10.5772/intechopen.69542",slug:"permanent-maxillary-and-mandibular-incisors",totalDownloads:2541,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The permanent incisors are the front teeth that erupt between 6 and 8 years of age. They are eight in number, four upper and four lower, two centrals and two laterals. They have sharp biting surfaces designed for shearing and cutting of food materials into small chewable pieces. They are the teeth most visible to the others during eating, smiling and talking, and thus, they have high aesthetic value for the individuals. The unique characteristics, arch position, function, development and chronological age of each tooth will be highlighted. In addition, the different aspects with their geometric outlines, outlines and surface anatomy of these teeth will be described. A brief explanation about the pulp cavity, tooth socket and normal occlusion for each tooth will be included.",signatures:"Mohammed E. Grawish, Lamyaa M. Grawish and Hala M. Grawish",downloadPdfUrl:"/chapter/pdf-download/56461",previewPdfUrl:"/chapter/pdf-preview/56461",authors:[{id:"82989",title:"Prof.",name:"Mohammed",surname:"Grawish",slug:"mohammed-grawish",fullName:"Mohammed Grawish"}],corrections:null},{id:"62386",title:"The Permanent Maxillary and Mandibular Premolar Teeth",doi:"10.5772/intechopen.79464",slug:"the-permanent-maxillary-and-mandibular-premolar-teeth",totalDownloads:2717,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The permanent premolar teeth are placed between the anterior teeth and molars. Eight premolars are found in the permanent dentition, four per arch and two in each quadrant. The main function of premolars is to assist the canines in regard to tear and pierce the food and supplement the grinding of the molars during mastication. The other functions are to support the corners of the mouth reinforce esthetics during smiling and maintain the vertical dimension. Detailed morphology of the permanent premolar teeth is narrated in a pointwise and systematic manner in this chapter.",signatures:"Işıl Çekiç Nagaş, Ferhan Eğilmez and Bağdagül Helvacioğlu Kivanç",downloadPdfUrl:"/chapter/pdf-download/62386",previewPdfUrl:"/chapter/pdf-preview/62386",authors:[{id:"178570",title:"Dr.",name:"Bağdagül",surname:"Helvacıoğlu Kıvanç",slug:"bagdagul-helvacioglu-kivanc",fullName:"Bağdagül Helvacıoğlu Kıvanç"}],corrections:null},{id:"57546",title:"Dental Anatomical Features and Caries: A Relationship to be Investigated",doi:"10.5772/intechopen.71337",slug:"dental-anatomical-features-and-caries-a-relationship-to-be-investigated",totalDownloads:1666,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Dental caries is a multifactor disease affecting a significant number of people throughout the world. However, in recent decades the widespread availability of fluoride and other preventive measures have resulted in a decline in the prevalence of caries among children and young adults. Currently, it is accepted that most carious dental lesions are restricted to specific anatomical sites. The aim of this chapter is to review the influence of dental anatomy on dental caries development while taking into account recent findings in cariology. Occlusal fissures in the first permanent molar are generally the first sites in the permanent dentition to develop caries. An increased risk of caries is also found in proximal contacting surfaces between two adjacent teeth. Moreover, a partially erupted tooth, which does not participate in mastication, is also at risk for caries since it may provide a more favorable environment for bacterial accumulation than a fully erupted tooth. Bacterial biofilm on the tooth is frequently a high risk caries environment. Understanding anatomical dental features is of great importance for guiding oral health hygiene and preventive measures. Finally, the development of dental disorders plays an important role in dental caries risk.",signatures:"Marcel Alves Avelino de Paiva, Dayane Franco Barros Mangueira\nLeite, Isabela Albuquerque Passos Farias, Antônio de Pádua\nCavalcante Costa and Fábio Correia Sampaio",downloadPdfUrl:"/chapter/pdf-download/57546",previewPdfUrl:"/chapter/pdf-preview/57546",authors:[{id:"138852",title:"Prof.",name:"Fabio",surname:"Sampaio",slug:"fabio-sampaio",fullName:"Fabio Sampaio"},{id:"213662",title:"Prof.",name:"Isabela Albuquerque",surname:"Passos Farias",slug:"isabela-albuquerque-passos-farias",fullName:"Isabela Albuquerque Passos Farias"},{id:"213663",title:"Prof.",name:"Dayane Franco",surname:"Barros Mangueira Leite",slug:"dayane-franco-barros-mangueira-leite",fullName:"Dayane Franco Barros Mangueira Leite"},{id:"213664",title:"BSc.",name:"Marcel Alves",surname:"Avelino De Paiva",slug:"marcel-alves-avelino-de-paiva",fullName:"Marcel Alves Avelino De Paiva"},{id:"213666",title:"Prof.",name:"Antonio De Pádua",surname:"Cavalcante Da Costa",slug:"antonio-de-padua-cavalcante-da-costa",fullName:"Antonio De Pádua Cavalcante Da Costa"}],corrections:null},{id:"56119",title:"Anatomy Applied to Block Anesthesia for Maxillofacial Surgery",doi:"10.5772/intechopen.69545",slug:"anatomy-applied-to-block-anesthesia-for-maxillofacial-surgery",totalDownloads:1506,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Anatomy is a basic knowledge that every clinician must have; however, its full management is not always achieved and gaps remain in daily practice. The aim of this chapter is to emphasize the most relevant aspects of head and neck anatomy, specifically related to osteology and neurology for the application of regional anesthesia techniques. This chapter presents a clear and concise text, useful for both undergraduate and graduate students and for the dentist and maxillofacial surgeon. The most relevant aspects of the bone and sensory anatomy relevant for the realization of regional anesthetic techniques in the oral and maxillofacial area are reviewed, including complementary figures and tables. The anatomy related to the techniques directed to the three major branches of the trigeminal nerve (ophthalmic nerve, maxillary nerve, and to the branches of the mandibular nerve) will be approached separately.",signatures:"Alex Vargas, Paula Astorga and Tomas Rioseco",downloadPdfUrl:"/chapter/pdf-download/56119",previewPdfUrl:"/chapter/pdf-preview/56119",authors:[{id:"199400",title:"Dr.",name:"Alex",surname:"Vargas",slug:"alex-vargas",fullName:"Alex Vargas"},{id:"202023",title:"Dr.",name:"Paula",surname:"Astorga",slug:"paula-astorga",fullName:"Paula Astorga"},{id:"205059",title:"Dr.",name:"Tomas",surname:"Rioseco",slug:"tomas-rioseco",fullName:"Tomas Rioseco"}],corrections:null},{id:"55902",title:"Treatment Considerations for Missing Teeth",doi:"10.5772/intechopen.69543",slug:"treatment-considerations-for-missing-teeth",totalDownloads:961,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Specific terms are used to describe the nature of tooth agenesis. Hypodontia is most frequently used when describing the phenomenon of congenitally missing teeth. Many other terms to describe a reduction in the number of teeth appear in the literature: oligodontia, anodontia, aplasia of teeth, congenitally missing teeth, absence of teeth, agenesis of teeth and lack of teeth. The term hypodontia is used when one to six teeth, excluding third molars, are missing, and oligodontia when more than six teeth are absent (excluding the third molars). The long‐term management of hypodontia in the aesthetic zone is a particularly challenging situation. Although there are essentially two distinct approaches to manage this problem, that is space closure or opening for prosthetic replacements, implant or autotransplantation. These patients often manifest with many underlying skeletal and dental problems and a multidisciplinary approach for management of this condition is recommended. Two treatment approaches including space closure and space reopening are described in details in this chapter.",signatures:"Abdolreza Jamilian, Alireza Darnahal, Ludovica Nucci, Fabrizia\nD’Apuzzo and Letizia Perillo",downloadPdfUrl:"/chapter/pdf-download/55902",previewPdfUrl:"/chapter/pdf-preview/55902",authors:[{id:"171777",title:"Prof.",name:"Abdolreza",surname:"Jamilian",slug:"abdolreza-jamilian",fullName:"Abdolreza Jamilian"},{id:"171873",title:"Dr.",name:"Alireza",surname:"Darnahal",slug:"alireza-darnahal",fullName:"Alireza Darnahal"},{id:"173044",title:"Prof.",name:"Letizia",surname:"Perillo",slug:"letizia-perillo",fullName:"Letizia Perillo"},{id:"198961",title:"MSc.",name:"Fabrizia",surname:"D'Apuzzo",slug:"fabrizia-d'apuzzo",fullName:"Fabrizia D'Apuzzo"},{id:"206137",title:"Mrs.",name:"Ludovica",surname:"Nucci",slug:"ludovica-nucci",fullName:"Ludovica Nucci"}],corrections:null},{id:"55973",title:"Anatomical and Functional Restoration of the Compromised Occlusion: From Theory to Materials",doi:"10.5772/intechopen.69544",slug:"anatomical-and-functional-restoration-of-the-compromised-occlusion-from-theory-to-materials",totalDownloads:1249,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Many conditions can alter the occlusal interface, from tooth wear to tooth loss. The masticatory system is constituted by many components that can influence each other like muscles, joints, teeth and nervous system. This implies that (a) every change at occlusal level makes the other components to adapt and (b) an occlusal alteration may be the effect of an alteration occurred on muscles or joints. Keeping this in mind, traditional principles of occlusal rehabilitation are analysed, and the choice of the restorative materials is discussed.",signatures:"Nicola Mobilio and Santo Catapano",downloadPdfUrl:"/chapter/pdf-download/55973",previewPdfUrl:"/chapter/pdf-preview/55973",authors:[{id:"179565",title:"Dr.",name:"Nicola",surname:"Mobilio",slug:"nicola-mobilio",fullName:"Nicola Mobilio"},{id:"199397",title:"Prof.",name:"Santo",surname:"Catapano",slug:"santo-catapano",fullName:"Santo Catapano"}],corrections:null},{id:"57245",title:"Evaluation of the Anatomy of the Lower First Premolar",doi:"10.5772/intechopen.71038",slug:"evaluation-of-the-anatomy-of-the-lower-first-premolar",totalDownloads:877,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter provides information about the lower first premolars. This tooth is considered to be one of the most complex teeth and the dentistry graduation students usually have difficulties in identifying it. The aim of this chapter is to present a detailed morphological study of extracted lower first premolars. One hundred lower first premolars, belonging to the collection of the Laboratory of Anatomy of the Department of Morphology of the São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil, were evaluated. Nine measurements were performed through direct observation without any instruments. Other 20 measurements were made by photographs and they were analyzed by the Image Tool 3.0 program. According to the results, it was concluded that most of the teeth presented the following features such as one lingual cusp; the distal occlusal pits were wider than the mesial occlusal pits; an enamel bridge linking the buccal and lingual cusps; the grooves in the lingual surface that emerged from the mesial and distal occlusal pits were absent, and where the grooves were present, they emerged from the mesial occlusal pit; one rectilinear root with no root grooves and where the root groove was present, it was observed in the mesial surface.",signatures:"Ticiana Sidorenko de Oliveira Capote, Suellen Tayenne Pedroso\nPinto, Marcelo Brito Conte, Juliana Álvares Duarte Bonini Campos\nand Marcela de Almeida Gonçalves",downloadPdfUrl:"/chapter/pdf-download/57245",previewPdfUrl:"/chapter/pdf-preview/57245",authors:[{id:"87871",title:"Prof.",name:"Ticiana",surname:"Capote",slug:"ticiana-capote",fullName:"Ticiana Capote"},{id:"199157",title:"Prof.",name:"Marcela",surname:"De Almeida Gonçalves",slug:"marcela-de-almeida-goncalves",fullName:"Marcela De Almeida Gonçalves"},{id:"199243",title:"BSc.",name:"Marcelo",surname:"Brito Conte",slug:"marcelo-brito-conte",fullName:"Marcelo Brito Conte"},{id:"199244",title:"Prof.",name:"Juliana",surname:"Álvares Duarte Bonini Campos",slug:"juliana-alvares-duarte-bonini-campos",fullName:"Juliana Álvares Duarte Bonini Campos"},{id:"217420",title:"Mrs.",name:"Suellen",surname:"Tayenne Pedroso Pinto",slug:"suellen-tayenne-pedroso-pinto",fullName:"Suellen Tayenne Pedroso Pinto"}],corrections:null},{id:"57752",title:"A Comparative Study of the Validity and Reproducibility of Mesiodistal Tooth Size and Dental Arch with iTeroTM Intraoral Scanner and the Traditional Method",doi:"10.5772/intechopen.70963",slug:"a-comparative-study-of-the-validity-and-reproducibility-of-mesiodistal-tooth-size-and-dental-arch-wi",totalDownloads:894,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Introduction: The introduction of intraoral scanning offers an alternative for measuring mesiodistal tooth sizes.",signatures:"Ignacio Faus-Matoses, Ana Mora, Carlos Bellot-Arcís, Jose Luis\nGandia-Franco and Vanessa Paredes-Gallardo",downloadPdfUrl:"/chapter/pdf-download/57752",previewPdfUrl:"/chapter/pdf-preview/57752",authors:[{id:"150456",title:"Prof.",name:"Vanessa",surname:"Paredes",slug:"vanessa-paredes",fullName:"Vanessa Paredes"},{id:"150458",title:"Prof.",name:"José-Luis",surname:"Gandia-Franco",slug:"jose-luis-gandia-franco",fullName:"José-Luis Gandia-Franco"},{id:"212242",title:"Prof.",name:"Ignacio",surname:"Faus",slug:"ignacio-faus",fullName:"Ignacio Faus"},{id:"212243",title:"Prof.",name:"Carlos",surname:"Bellot-Arcís",slug:"carlos-bellot-arcis",fullName:"Carlos Bellot-Arcís"},{id:"218390",title:"Prof.",name:"Ana",surname:"Mora",slug:"ana-mora",fullName:"Ana Mora"}],corrections:null},{id:"57378",title:"Identification of Lower Central Incisors",doi:"10.5772/intechopen.71341",slug:"identification-of-lower-central-incisors",totalDownloads:837,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Unlike the other teeth, the permanent lower central incisors have great symmetry between the proximal surfaces, being difficult to distinguish them. It was intended to facilitate the study of the anatomy of the lower central incisor for dentistry students, that this study searched for a better way to differentiate the third quadrant element (31) from the fourth quadrant element (41). The purpose of this chapter was to evaluate 100 permanent lower central incisors of the didactic collection of the Discipline of Anatomy of the Department of Morphology of the School of Dentistry of Araraquara - UNESP and to verify the presence of correlation between the some anatomical features. Besides, it was evaluated if there was difference between 31 and 41. It was verified that the systematic methodology used for the evaluation of the incisors in this study facilitated the identification of the teeth. There was no statistically significant difference between the measurements of 31 and 41. Distinguishing the right from the left central incisor is difficult, even for experienced practitioners. We could observe that the measurements do not facilitate the identification of teeth of different quadrants. Therefore, the anatomical features are relevant for the study of the dental anatomy in the identification of the lower central incisors.",signatures:"Marcela de Almeida Gonçalves, Bruno Luís Graciliano Silva, Marcelo\nBrito Conte, Juliana Álvares Duarte Bonini Campos and Ticiana\nSidorenko de Oliveira Capote",downloadPdfUrl:"/chapter/pdf-download/57378",previewPdfUrl:"/chapter/pdf-preview/57378",authors:[{id:"199157",title:"Prof.",name:"Marcela",surname:"De Almeida Gonçalves",slug:"marcela-de-almeida-goncalves",fullName:"Marcela De Almeida Gonçalves"},{id:"199243",title:"BSc.",name:"Marcelo",surname:"Brito Conte",slug:"marcelo-brito-conte",fullName:"Marcelo Brito Conte"},{id:"199244",title:"Prof.",name:"Juliana",surname:"Álvares Duarte Bonini Campos",slug:"juliana-alvares-duarte-bonini-campos",fullName:"Juliana Álvares Duarte Bonini Campos"},{id:"221435",title:"Mr.",name:"Bruno Luis Graciliano",surname:"Silva",slug:"bruno-luis-graciliano-silva",fullName:"Bruno Luis Graciliano Silva"},{id:"221438",title:"Prof.",name:"Ticiana Sidorenko De Oliveira",surname:"Capote",slug:"ticiana-sidorenko-de-oliveira-capote",fullName:"Ticiana Sidorenko De Oliveira Capote"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7572",title:"Trauma in Dentistry",subtitle:null,isOpenForSubmission:!1,hash:"7cb94732cfb315f8d1e70ebf500eb8a9",slug:"trauma-in-dentistry",bookSignature:"Serdar Gözler",coverURL:"https://cdn.intechopen.com/books/images_new/7572.jpg",editedByType:"Edited by",editors:[{id:"204606",title:"Dr.",name:"Serdar",surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8837",title:"Human Teeth",subtitle:"Key Skills and Clinical Illustrations",isOpenForSubmission:!1,hash:"ac055c5801032970123e0a196c2e1d32",slug:"human-teeth-key-skills-and-clinical-illustrations",bookSignature:"Zühre Akarslan and Farid Bourzgui",coverURL:"https://cdn.intechopen.com/books/images_new/8837.jpg",editedByType:"Edited by",editors:[{id:"171887",title:"Prof.",name:"Zühre",surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan"}],equalEditorOne:{id:"52177",title:"Prof.",name:"Farid",middleName:null,surname:"Bourzgui",slug:"farid-bourzgui",fullName:"Farid Bourzgui",profilePictureURL:"https://mts.intechopen.com/storage/users/52177/images/system/52177.png",biography:"Prof. Farid Bourzgui obtained his DMD and his DNSO option in Orthodontics at the School of Dental Medicine, Casablanca Hassan II University, Morocco, in 1995 and 2000, respectively. Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). He is the author of several scientific articles, book chapters, and books.",institutionString:"University of Hassan II Casablanca",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Hassan II Casablanca",institutionURL:null,country:{name:"Morocco"}}},equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9588",title:"Clinical Concepts and Practical Management Techniques in Dentistry",subtitle:null,isOpenForSubmission:!1,hash:"42deab8d3bcf3edf64d1d9028d42efd1",slug:"clinical-concepts-and-practical-management-techniques-in-dentistry",bookSignature:"Aneesa Moolla",coverURL:"https://cdn.intechopen.com/books/images_new/9588.jpg",editedByType:"Edited by",editors:[{id:"318170",title:"Dr.",name:"Aneesa",surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10126",title:"Dental Caries",subtitle:null,isOpenForSubmission:!1,hash:"0878a332413e67a1aa0a16fabeed9046",slug:"dental-caries",bookSignature:"Efka Zabokova Bilbilova",coverURL:"https://cdn.intechopen.com/books/images_new/10126.jpg",editedByType:"Edited by",editors:[{id:"275097",title:"Associate Prof.",name:"Efka",surname:"Zabokova Bilbilova",slug:"efka-zabokova-bilbilova",fullName:"Efka Zabokova Bilbilova"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9387",title:"Oral Diseases",subtitle:null,isOpenForSubmission:!1,hash:"76591a3bd6bedaa1c8d1f72870268e23",slug:"oral-diseases",bookSignature:"Gokul Sridharan, Anil Sukumaran and Alaa Eddin Omar Al Ostwani",coverURL:"https://cdn.intechopen.com/books/images_new/9387.jpg",editedByType:"Edited by",editors:[{id:"82453",title:"Dr.",name:"Gokul",surname:"Sridharan",slug:"gokul-sridharan",fullName:"Gokul Sridharan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7497",title:"Computer Vision in Dentistry",subtitle:null,isOpenForSubmission:!1,hash:"1e9812cebd46ef9e28257f3e96547f6a",slug:"computer-vision-in-dentistry",bookSignature:"Monika Elzbieta Machoy",coverURL:"https://cdn.intechopen.com/books/images_new/7497.jpg",editedByType:"Edited by",editors:[{id:"248279",title:"Dr.",name:"Monika",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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\r\n\tThe annual number of new cases of lung cancer is anticipated to be more than one million worldwide, with ten million expected by 2025. Lung cancer is the leading cause of death in the developed world, accounting for 20% of all cancer deaths. It's usually linked to smoking, although despite changes in smoking behaviours, it remains a leading cause of cancer death. Despite the fact that there are numerous approved medications for cancer treatment, drug resistance and delivery are two of the treatment's major obstacles. Furthermore, the pathogenic properties of tumors decrease the effectiveness of traditional cancer treatments. Therefore, looking for advances in drug delivery is essential. Recent developments in nanotechnology-based drug delivery systems including targeted approaches have resulted in a number of products flourishing in the oncology market. This book will aim to bring together scholarly articles from experts around the world working in the field of oncology and drug delivery.
",isbn:"978-1-80356-672-6",printIsbn:"978-1-80356-671-9",pdfIsbn:"978-1-80356-673-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"6f497f93fe6b46b394f80e9d00a4bbab",bookSignature:"Dr. Usama Ahmad and Dr. Mohd Aftab Aftab Siddiqui",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11653.jpg",keywords:"Lung Cancer Incidence, Tobacco Use, Epidemiology, Etiology, Radiotherapy, Chemotherapy, Combination Therapy, Immunotherapy, Nanochemotherapy, Nanomedicine, Liposomes, Targeted Therapy",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 22nd 2022",dateEndSecondStepPublish:"May 26th 2022",dateEndThirdStepPublish:"July 25th 2022",dateEndFourthStepPublish:"October 13th 2022",dateEndFifthStepPublish:"December 12th 2022",remainingDaysToSecondStep:"8 days",secondStepPassed:!1,currentStepOfPublishingProcess:1,editedByType:null,kuFlag:!1,biosketch:"Assistant Professor, author, and researcher with an interest in smart and novel drug delivery systems. 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He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Integral University",institutionURL:null,country:{name:"India"}}}],coeditorOne:{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:null,chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453622",firstName:"Tea",lastName:"Jurcic",middleName:null,title:"Ms.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"tea@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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During the last 15 years, cochlear implantation became available also as a treatment for different types of hearing impairment. Regardless of surgical technique for cochlear implantation (cochleostomy or an approach through the round window), specialized centers have now introduced the comprehensive analysis of the nonsurgical factors that could contribute to improve rates of hearing preservation in preoperative, during surgery, or in postoperative period in patients who suffer from partial deafness. One of the approaches of many leading research centers is using pharmacotherapy (glucocorticoids) as a factor which may improve hearing functions following cochlear implantation [1, 2]. Glucocorticoids play an important role in pharmacotherapy of many different otorhinolaryngological diseases, such as Meniere’s disease, sudden sensorineural hearing loss (SSNHL), and tinnitus, and as a part of otorhinolaryngological procedures in surgeries (e.g., cochlear implantation) [3, 4]. The effects of treatment listed diseases are different and mainly depend on treatment results, adverse effects of used medications, and additional pharmacological treatment that was used during treatment. Unfortunately, the side effects of glucocorticoids are serious, and as the result, sometimes pharmacotherapy has to be stopped, and discontinuation of therapy is the only solution.
\nOn the one hand, insertion of specific electrode of cochlear implant requires perfection in surgical techniques, but on the other it is difficult to do perfectly. Clinically approved algorithm of corticosteroid therapy (local or systematic) is discussed as one factor in reducing oxidative stress, an inflammatory reaction, and as a result apoptosis of hearing cells. A major challenge in effective administration and delivery medicines is the
The adrenal cortex synthesizes two classes of steroids: corticosteroids (mineralocorticoids and glucocorticoids) and androgens. One of the differences is the number of carbon atoms. Corticosteroids have 21 carbon atoms, and androgens have 19 carbon atoms. In the human body, the main glucocorticoid is cortisol, and the main mineralocorticoid is aldosterone [5].
\nGlucocorticoid receptor (GR) is located in the cytoplasm in inactive form until it binds with the molecule of glucocorticoid. This action results in activation of receptor and translocation complex:
\n | Anti-inflammatory activity | \nBiological half-life t1/2 (h) | \n
---|---|---|
Cortisol | \n1 | \nShort: t1/2 = 8–12 | \n
Cortisone | \n0.8 | \nShort: t1/2 = 8–12 | \n
Fludrocortisone | \n10 | \nIntermediate: t1/2 = 12–36 | \n
Prednisone | \n4 | \nIntermediate: t1/2 = 12–36 | \n
Prednisolone | \n4 | \nIntermediate: t1/2 = 12–36 | \n
6α-methylprednisone | \n5 | \nIntermediate: t1/2 = 12–36 | \n
Triamcinolone | \n5 | \nIntermediate: t1/2 = 12–36 | \n
Betamethasone | \n25 | \nLong: t1/2 = 36–72 | \n
Dexamethasone | \n25 | \nLong: t1/2 = 36–72 | \n
Characteristics of representative corticosteroids [5].
The two key roles glucocorticoids play as biological and pharmaceutical compounds are anti-inflammatory and immunosuppressive roles. Glucocorticoids also affect:
Carbohydrate and protein metabolism. Glucocorticoids stimulate the liver to form glucose in biochemical reaction (gluconeogenesis) from amino acids and glycerol or/and stimulate the liver to release glucose from glycogen. At the same time, the diminishing of glucose is reduced, reaction of lipolysis and protein breakdown increases, and as a result the blood glucose level rises. Patients suffering from diabetes or other forms of hyperglycemia during glucocorticoid therapy should be under special control. Glucocorticoids induce increased protein metabolism and deliver compounds such as amino acids for further reactions.
Lipid metabolism. One effect of therapy with corticosteroids is redistribution of fat tissue known as Cushing’s syndrome.
Water and electrolyte balance. Glucocorticoids exert negatively on metabolism of Ca2+ due to reduction of absorption from the digestive system and increased excretion via kidneys. Prophylaxis of osteoporosis requires supplementation of Ca2+ ions and physical activity adequate to possibilities of patient. Additionally, glucocorticoids reduce activity of osteoclasts and stimulate the activity of osteoblasts. Glucocorticoid therapy sometimes may cause increased retention of Na+ ions and decrease in concentration of K+ ions because of interaction with receptor for mineralocorticoids. The deterioration in ion level may affect the cardiovascular system.
Impaired wound healing. Due to reduction of synthesis of collagen, glycosaminoglycans and disturbance in fibroblast function problem with healing wound may occur.
Anti-inflammatory and immunosuppressive activity. Glucocorticoids can suppress or prevent inflammatory reactions in different ways: reduction in diapedesis of granulocytes and proliferation of lymphocytes Th, inhibition/reduction of activation of macrophages, neutrophils, mast cells and cytokines (interleukins 1, 2, 3, 4, 5, 6, 8), and tumor necrosis factor alpha (TNF-α); reduction in the expression of cyclooxygenase 2 (COX-2) resulting in dropping of production of a few prostanoids; intensification of activity of catechol amines; and reduction in production of histamine by basophils [7, 8].
Sometimes glucocorticoid treatment in the otorhinolaryngological diseases requires high doses or long time of therapy. It may cause adverse effects. Some of them are listed below:
Repression in responding on infections and injuries
Propensity to opportunistic infections
Propensity to hyperglycemia
Muscular dystrophy
Cushing’s syndrome
Glaucoma (mostly in patients genetically predisposed)
Osteoporosis
Acute discontinuation of treatment may cause adrenocortical insufficiency, especially when therapy was long-term. It is important to reduce the dose of glucocorticoids slowly, not suddenly [5].
\nMany factors have an impact on pharmacokinetics of drugs. Pharmacokinetics is described by acronym
In a study published in 2017, authors in animal model (guinea pig) compared dexamethasone with saline. Both substances were administrated intravenously 60 min before implantation. As a final conclusion, authors stressed that dexamethasone could reduce scarring process as the electrode negotiated the hook region or near the electrode tip, but they did not observe the relation between dexamethasone and reduction of fibrosis relating to cochleostomy [13]. In vitro studies showed the correlation between reduction (loss) of auditory cells after exposure to
Research carried out on animal model proved that prolonged steroid therapy could significantly improve hearing preservation rate (including pharmacokinetic and morphological analysis) when the electrode of cochlear implants was covered with dexamethasone (special formulation with controlled drug release) [14]. However, Honeder et al. did not confirm that steroids could have a positive impact on residual hearing in a guinea pig model. One reason why both authors gain different results may lie in different types of steroid therapy. In the first study, dexamethasone was used on the contrary to the second study where triamcinolone was administrated [15]. Douchement et al. investigated the effects of steroids using a gerbil animal model. Animals were implanted with an electrode with controlled dexamethasone delivery (1 and 10% concentration of dexamethasone) on one side and a conventional electrode on the contralateral side. Hearing levels were established based on the tone bursts on auditory brain stem responses at 4–6-week postimplantation and at 1-year postimplantation period for older gerbils. A 1-year observation period showed significantly improved results obtained for the high auditory frequencies, but the results for the low frequencies were ambiguous [16].
\nCho et al. analyzed the efficacy of preoperative and intraoperative schemes of administration of steroids for hearing preservation. Dexamethasone was administrated systematically at the dose of 5 mg/ml in the preoperative period and then topically (off-label) during cochlear implantation surgery. Pure tone audiometry (PTA) was measured in four frequencies: 250, 500, 1000, and 2000 Hz. Statistically significant differences were observed between the steroid group and the control group, supporting the observation and beneficial impact of administration steroid treatment [17].
\nDuring treatment of otologic diseases, two routes of administration of glucocorticoids are possible: local and systemic. Local administration (e.g., transtympanic injection) allows to achieve high concentration of glucocorticoid in the middle ear, but due to presence of Eustachian tube, the medication may be partly evacuated. Local drug administration to the middle and inner ear avoids “the first pass effect.” The main advantages of local drug delivery are as follows:
Reduction dose of medicine
Achieving high concentration
Better effects of treatment
Reducing possibility of adverse effects
Bypassing of the blood-labyrinth barrier (BLB)
Local drug administration may involve intracochlear administration (e.g., stem cell, gene therapy) or extracochlear administration (e.g., intratympanic injection). A combination of both routes of drug delivery to the ear is also possible [13]. According to publications, systemic administration in treatment of otorhinolaryngological diseases is known as noninvasive route of drug delivery, due to lack of damaging of tympanic membrane. Adverse effects of systemic delivery may be one of the purposes of discontinuation of the therapy. The presence of
This study was the first study which was carried out in the Institute of Physiology and Pathology of Hearing World Hearing Center and will be continued with different groups of patients and different implants and algorithms of glucocorticoid administration. The aim of the study was to evaluate different regimes of administration of glucocorticoids: dexamethasone and dexamethasone/prednisone to
Preoperatively
During activation of audio processor
One month after activation of audio processor
Six months after activation of audio processor
Nine months after activation of audio processor
One year (12 months) after activation of audio processor
Forty-six patients were enrolled to the trial and then divided randomly into three subgroups. Patients from the first subgroup underwent intravenous steroid therapy (Figure 1). According to the scheme, 30 min before implantation, dexamethasone at the dose of 0.1 mg/kg body mass was administrated intravenously to patients from the first subgroup. For the next 3 consecutive days in every 12 h, dexamethasone was administrated intravenously at the same dose to each patient.
\nScheme of steroid administration in the first subgroup of patients.
Patients from the second subgroup underwent prolonged (combined) steroid therapy: oral and intravenous. Three days prior to the surgery, prednisone was administrated orally at a dose of 1 mg/kg body mass/day. Then, 30 min before the cochlear implantation surgery, dexamethasone was administrated intravenously at a dose of 0.1 mg/kg body mass. For the next 3 consecutive days in every 12 h, dexamethasone was administrated intravenously (the same as in the first subgroup). For the next 3 days, prednisone was administrated orally at the dose of 1 mg/kg body mass/day. After this period, the dose of prednisone was reduced (10 mg per every day) till complete reduction of dose, due to reducing the risk of adverse effects. The algorithm of administration of glucocorticoids to patients form the second subgroup is presented below (Figure 2).
\nScheme of steroid administration in the second subgroup of patients.
The third subgroup was a control group and underwent standard cochlear implantation procedure [18].
\nAccording to the protocol of this study, two different algorithms of administration with two different glucocorticoids were proposed in the study. Although both substances belong to the same pharmacological group, both of them have different pharmacokinetics and pharmacodynamic properties. Dexamethasone is a synthetic glucocorticoid (
Prednisone is a synthetic glucocorticoid (derivative of cortisone) and classified according to the
The primary outcome variables were mean values of hearing thresholds averaged across all 11 frequencies (125–8000 Hz). The secondary outcome variable was hearing preservation (HP). Hearing preservation (HP) was calculated by comparing hearing thresholds in the 1-year postoperative period with the preoperative hearing thresholds, according to the hearing preservation (HP) formula (below) and converted to three levels: minimal, partial, and complete hearing preservation.
\nIn this equation,
The protocol of this prospective clinical trial was approved by the Bioethics Commission. Patients enrolled to the study suffered from severe-to-profound hearing loss and were classified according to Prof. H. Skarżyński
Partial deafness treatment groups for cochlear implantation. ENS, electro-natural stimulation; EC, electrical complement; EAS, electrical-acoustic stimulation; ES, electrical stimulation.
Inclusion and exclusion criteria were in accordance with the consensus of the international
Hearing sound levels in the range of 10–120 decibels (dB) and sound frequencies of 125–250 hertz (Hz)
Hearing sound levels of 35–120 dB and frequencies of 500–1000 Hz
Hearing sound levels of 75–120 dB and frequencies of 2000–8000 Hz [18]
Exclusion criteria included suffering from severe diseases when the steroid treatment could worsen the patient’s condition or when there would be a possibility of interaction between medication intake by patients and steroids. Nonparametric tests were used in the study due to discrepancies in the number of participants between all subgroups, small number of participants in the study, and violation of normal distribution of pure tone audiometry results [18].
\nPreoperative hearing threshold levels of patients from the first, the second, and the control subgroup were similar. The difference between patients from the three subgroups was not statistically significant, which means that hearing thresholds in preoperative period of all participants, who were enrolled to the study, were similar.
\nThe deterioration of average hearing thresholds (measured by pure tone audiometry) was observed from the first point of observation—the activation period. A significant difference was observed between two groups: patients from the second subgroup (combined steroid therapy, prednisone + dexamethasone) and the control subgroup. Patients from the second subgroup had better pure tone audiometry (PTA) results considering low frequencies in comparison with the results of patients from the control group. Similar observation was done in 1, 6, 9, and 12 months after activation follow-up periods. The results of the study may be even more a promise and beneficial for patients. The hearing of participants of the study, to whom combined (prolonged) glucocorticoid therapy was administrated, remained stable during all observed follow-up periods (
Mean hearing thresholds of patients with standard steroid therapy (subgroup No 1), patients with prolonged steroid therapy (subgroup No 2), and control patients (subgroup No 3) in the preoperative period, upon activation, and at 1-month, 6-month, 9-month, and 12-month follow-up after CI implantation.
The hearing preservation (HP) rate is calculated using hearing preservation formula by comparing hearing threshold in the 12-month postoperative period with the preoperative hearing thresholds. Then the results were divided, according to the hearing preservation (HP) formula, into minimal HP, partial HP, and complete HP according to Table 2. The smallest variability of results was observed in the second subgroup (patients to whom prednisone and dexamethasone were administrated) as well as the highest overall HP rate. Patients from the second subgroup (prolonged steroid therapy) and nearly 69% of the patients from the first subgroup had partial or complete hearing preservation. The majority of patients from the control group had minimal hearing preservation (Table 2 and Figure 5).
\n\n | Minimal (0–25%) | \nPartial (26–75%) | \nComplete (≤75%) | \n
---|---|---|---|
Subgroup No 1 | \n5 (31.2) | \n7 (43.8) | \n4 (25.0) | \n
Subgroup No 2 | \n0 (0.0) | \n8 (61.5) | \n5 (38.5) | \n
Control group | \n12 (70.6) | \n3 (17.6) | \n2 (11.8) | \n
Hearing preservation 12 months after CI implantation, according to the type of treatment (data are given as the number of patients (percentage in brackets).
Hearing preservation (HP) rate in three subgroups.
This study is the first study to report the results of two different regimes of steroid administration in human subjects who underwent cochlear implantation in comparison with the control group. As it was said in the previous paragraph, the findings of this study have shown that glucocorticoid therapy not only stabilizes hearing thresholds but also preserves hearing ability in adult patients. The combination of
Epoxy resin adhesive (ERA) is the general term for polymers with two or more epoxy groups in the molecule. It is widely used in industries and is an important thermosetting resin adhesive [1, 2]. ERA is a thermosetting adhesive with strong adhesion, high cohesion, low shrinkage, low cost and low creep rate. It can be used for several materials, such as metal, cement and wood; thus, it is referred to as a ‘universal and strong’ glue [3]. It has a history of more than 70 years. The molecular end of epoxy resin is connected with epoxy groups. During curing, hydroxyl and ether bonds are formed, and the structure contains benzene or heterocyclic rings. Due to the presence of epoxy groups, hydroxyl groups, ether bonds, ester groups and other polar groups, it has a strong bonding effect on many substances other than non-polar polymers [4]. After the epoxy-based adhesive is cured, it forms a complex three-dimensional (3D) network structure with strong cohesion. The epoxy-based adhesive hardly generates low-molecular products during curing, has a small linear expansion coefficient, stable dimensions, small internal stress and better bonding strength. Epoxy-based adhesives meet the requirements of structural adhesives, but they also have some shortcomings. Because the curing process of epoxy-based adhesives needs a higher temperature, and it contains many rigid groups, such as a benzene or heterocyclic ring, the flexibility of the molecular chain is minimal [5]. Besides, after cross-linking to form a network structure, the deformability is further weakened, showing strong brittleness, which results in low bonding strength, poor impact strength, delamination and easy cracking resulting of epoxy-based adhesives [3]. Meanwhile, its flame retardancy is poor. As a structural adhesive, it is expected to cure quickly, have higher heat resistance and flame retardancy. Therefore, epoxy-based adhesives must be modified to expand its scope of application. This study mainly introduces the curing, heat resistance, toughening and flame-retardant modification of epoxy-based adhesives and their application in different fields.
As a thermosetting adhesive, ERA must be cured at high temperatures. However, for industrial applications, it must be cured at room temperature [6, 7], so the importance of developing curing agents for epoxy-based adhesive cured at room temperature is self-evident. Especially, room-temperature fast-curing epoxy adhesives can be used in aerospace and marine engineering applications, as well as in traditional manufacturing and daily life [8, 9], because of their fast-curing speed, high strength and strong durability [10]. With the continuous development of curing agents, room-temperature fast-curing ERAs as chemical products have become indispensable in the manufacturing industry [11]. The room-temperature curing of ERAs is an energy-saving curing method. The curing process is simple, and it is suitable for various curing situations that do not require heating.
According to the curing temperature, epoxy-based adhesive curing agents can be divided into amines, acid anhydrides, synthetic resins and latent curing agents by different chemical components. Among them, amine-curing agents are often used in ambient curing at room temperature [12]. Amine-curing agents are the earliest room-temperature curing agent used. It adheres excellently to most adherents. However, amine-curing agents have high volatility and toxicity and have strong water and carbon dioxide absorption abilities. The cured surface is prone to whitening and blistering [13]. Among the amine-curing agents, there are mainly polyamides, aliphatic amines, alicyclic amines. In industrial applications, curing agents, such as aliphatic amines, polyamides and alicyclic amines, are often used [14].
As one commonly used curing agent, polyamide accounts for more than 30% of the total epoxy resin-curing agents. It is mainly made of dimers or unsaturated fatty acids and polyamine as raw materials and forms amide bonds through dehydration condensation [15]. Among them, the dimerised fatty acid polyamide can overcome the shortcomings of epoxy-based adhesives’ fragility and has low toxicity, good workability and high-paint film adhesion [16]. Modifying the polyamide-curing agent can effectively improve the properties of epoxy resins. For example, Bryan et al. [17] used polyamide and phthalic anhydride as the curing agent of epoxy resin to improve the curing rate at room temperature. Gholipour et al. [18] improved the thermal properties of epoxy resins by preparing polyamidoamine (PAMAM) dendrimer-curing agents grafted with graphene oxide.
The amount of aliphatic amine-curing agents in various curing agents is second only to polyamide because most are liquid and have good miscibility with epoxy resin. Epoxy resin can be cured at room temperature. Modifying the aliphatic amine-curing agent can effectively improve the mechanical properties of epoxy resin. For example, Patel et al. [19] brominated unsaturated castor oil, which was the main raw material, and reacted the resulting material with excess aliphatic diamines, such as ethylenediamine, 1,3-propanediamine and 1,6-hexanediamine, to obtain an amino-functionalised castor-oil-curing agent to improve the mechanical strength of epoxy resins. Wan et al. [20] synthesised a novel low-volatility star aliphatic polyamine with extremely high-NH2 functional groups as the curing agent of bisphenol A diglycidyl ether epoxy resin. The novel curing agent has a high reaction activity, and the reaction has autocatalytic properties. Additionally, compared with linear propylene diamine, it can significantly increase the crosslinking density and glass transition temperature (Tg) of the cured epoxy resin.
Alicyclic amines are amine compounds containing alicyclic rings. The alicyclic amine-curing agent has many spatial conformations and good flexibility. Most alicyclic amines are low-viscosity liquids with long pot life and excellent chroma and gloss. Alicyclic polyamine compounds are widely used as curing agents for epoxy-resin adhesives and other structure adhesives because the molecular structure contains alicyclic rings (five-membered or six-membered rings) with higher stiffness and better stability. Xu et al. [21] used alicyclic polyamines and acrylonitrile to synthesise the curing agent to improve the bonding strength of epoxy-resin-based adhesives.
ERAs can withstand high temperatures up to 175°C and are compatible with all common reinforcement materials. A higher-temperature-resistant ERA can be essentially applied in many fields. In addition to having high-temperature-resistant properties, it can also show strong properties in many aspects, such as high-temperature-resistant epoxy. It has excellent mechanical properties, relatively outstanding strength and has good corrosion resistance and insulation properties [22, 23]. Therefore, research on high-temperature-resistant ERA is extremely necessary. There are two main measures in implementing the modification of high-temperature ERA. The first measure entails introducing new structures into the epoxy resin itself to improve its high-temperature properties. The second measure is blending or co-polymerisation to modify the high-temperature epoxy resin.
The modification treatment of high-temperature-resistant ERA is mainly performed to promote the structure of ERA to be changed to a certain extent. It is more common to improve the high-temperature resistance effect by introducing new structures. This method for introducing a new structure through the epoxy resin also involves many types of processing in actual implementation. For example, the effective use of multifunctional structures can promote the formation of ring structures [24]. The functionality of the epoxy-resin structure increases, which can promote the stability and cross-linking density of the corresponding structure and finally effectively enhance the high-temperature resistance of the epoxy resin. Furthermore, introducing rigid groups that have a good high-temperature resistance effect can promote the epoxy resin to show excellent performance, such as benzene ring, fused ring and biphenyl are some of the more commonly used rigid groups [25]. Moreover, Bismaleimide and epoxy resin may form an interpenetrating network or two-phase system during the polymerisation process, which improves the toughness and heat resistance of the epoxy resin [26].
Luo et al. [27] modified bisphenol A epoxy resin with bismaleimide and 4,4′-diaminodiphenylsulfone to produce a two-component high-strength bismaleimide modified epoxy-based adhesive with high cross-linking. The viscosity of the adhesive gradually decreases as temperature increases and can maintain good mechanical properties and storage stability. Cheng et al. [28] used 2,7-dihydroxynaphthalene and epi-chlorohydrin as raw materials to synthesise an epoxy-resin-based adhesive containing a naphthalene ring structure. Also, Yang et al. [29] used 1-naphthol and dicyclopentadiene as the main raw materials to synthesise an ERA containing naphthalene ring and dicyclopentadiene structure. The results show that the ERA has a higher heat resistance than the bisphenol A epoxy resin.
The blending and co-polymerisation methods can effectively and mainly help select an ideal material and ERA for effective combination to ensure greater high-temperature-resistant properties. Combined with the specific application and implementation of these methods, the requirements for specific blended or co-polymerised materials are relatively strict [6]. For example, the appropriate use of heat-resistant polymers, nano-materials and silicones can achieve ideal modifications. The treatment effect improves the heat resistance of the epoxy resin; besides, it can also guarantee its toughness or strength to be ideally optimised. Zhang et al. [30] modified ordinary bisphenol A epoxy resin with organic silicon active intermediates, added nitrile-40 and nano-TiO2 active fillers to toughen and strengthen the resin. The results showed that the modified ERA that could be cured at room temperature, used for a long time at 250°C and can withstand 300°C for a short period has been developed. Hu et al. [31] used polymethyltriethoxysilane (PTS) to react with a synthetic phosphorus-containing silane coupling agent in a certain ratio to modify the bisphenol A epoxy resin. The modified ERA retained its tensile strength. However, the Tg, high-temperature thermal stability, impact strength and limiting oxygen index (LOI) were all improved. Ramirez et al. [32] combined epoxycyclohexyldimethylsilyl with the curing agent 4,4′-(1,3-phenylene diisopropylidene) diphenylamine after coordination. Due to the dispersion of the heat-resistant epoxycyclohexyldimethylsilyl in the ERA, the silicon oxide compound formed during the thermal decomposition process deposited on the surface of the unburned polymer, partially forming a protective layer, slowing down the heat transfer to a certain extent and inhibiting the flammability as the gas volatilises, thereby preventing the mixture of flammable gas and oxygen.
ERAs are cost-effective and have simple moulding and processing methods, low chemical shrinkage after curing, good chemical stability, excellent mechanical properties and good bonding properties [33]. However, due to several epoxy groups, the cured structure has a high chemical cross-link density, low-molecular chain flexibility and high internal stress, resulting in greater brittleness, poor impact resistance and fatigue resistance of the ERA. It limits its application and development in some high-tech fields that require high durability and reliability.
ERA has good compatibility with rubber and other elastomers. After the rubber is dissolved in the uncured epoxy-resin matrix, the ERA undergoes a curing reaction, separates from the rubber and is dispersed in the resin to form a ‘sea island’ structure, thereby improving the toughness of the epoxy resin [34]. The rubber molecules containing no reactive groups cannot react with epoxy resin and will precipitate out during curing, which has a toughening effect. However, if excessively added, it weakens the adhesion of the bonding interface. Therefore, rubber molecules with active groups are generally used to modify and toughen epoxy resins. Carboxyl-terminated liquid nitrile rubber (CTBN) and amino-terminated liquid nitrile rubber (ATBN) have been widely mixed with epoxy resins to improve their toughness. For example, Wang et al. [35] used CTBN and ERA to prepare a structural adhesive with high shear and excellent peel strength. Meanwhile, to adapt to the application in different fields and improve the toughness of the cured ERA, flexible segments are often introduced into the curing agent to control its physical and chemical properties. Lou et al. [36] used dendritic polyester polyol as the branching unit and toughening segment and imidazole-terminated diisocyanate as a functional group to synthesise a functional toughening-curing agent to improve the toughness of ERAs. In the initial curing stage, several secondary hydroxyl groups react with the isocyanate groups to form a dendritic epoxy structure, and the bisphenol A epoxy molecule acts as a long-chain polyol to react with the dendritic epoxy structure. Simultaneously, the epoxy group opens a ring to form a secondary hydroxyl group and continuously reacts with the isocyanate group in the cross-linking structure. Furthermore, NH- existing in the carbamate reacts with the epoxy group, thereby obtaining an epoxy resin-curing cross-linking system with a 3D dendritic cross-linking structure. Thus, the toughness of epoxy resin has been greatly improved. Meanwhile, Zheng et al. [37] studied the toughening effect of nano-SiO2 on cycloaliphatic epoxy systems. They used nano-silica to improve the toughness of cycloaliphatic ERA. The coupling agent γ-glycidoxypropyltrimethoxysilane (KH-560) was used to modify the surface properties of SiO2. The results show that adding nano-SiO2 effectively improves the toughness and thermal stability of the cycloaliphatic ERA.
ERAs have been widely used due to their excellent properties [38]. However, the conventional ERA is formed from reacting bisphenol A and epi-chlorohydrin [39]. It is flammable when cured, which could cause a high fire risk when ERAs are used in certain applications, such as printed manufacture, furniture, aircraft and train interiors [40]. Serious consequences could occur due to the high release rate of heat and smoke accompanied by the combustion of epoxy resins. Therefore, it is very important to enhance the flame retardancy of ERA for expanding their application in this field. Many studies have reported improving the flame retardancy of epoxy resins via structural modification or adding various flame retardants [41, 42]. Structural modification introduces the elements with flame-retardant functions into the molecular structure of ERAs. The representative of structural modification is brominated ERA, which is the reaction product of epi-chlorohydrin and brominated bisphenol A, such as tetrabromo diphenylolpropane. The brominated ERA has an outstanding flame ignition resistance, whereas the bromine content is ~18–20% in the finished adhesive. When the product is thermally decomposed at the temperature generated in the fire, it will release acid halide gas, which protects the product from fire. These halide gases act as extinguishers to significantly increase the ignition temperature of the cured ERA. The addition of flame retardants in ERA shows good properties, such as simple processing, low cost, wide source of raw materials and obvious flame-retardant effect. It is one of the most popular strategies for flame-retardant modification of ERA. Flame retardants could be an integral part of the ERA by reacting chemically with the polymers or simply mixed with the ERA without any reaction. All kinds of flame retardants work by acting chemically and/or physically either in the vapour phase and/or condensed phase to interfere with the combustion process during heating, pyrolysis, ignition or flame spread [43]. The types of flame retardants and their operating characteristics are described as follows [38]: (1) char formers: usually, phosphorus compounds, which remove the carbon fuel source and provide an insulation layer against the fire’s heat. (2) Heat absorbers: usually metal hydrates, such as aluminium trihydrate (ATH) or magnesium hydroxide, which remove heat by evaporating the water in their structure. (3) Flame quenchers: usually, bromine- or chlorine-based halogen systems that interfere with the reactions in a flame. (4) synergists: Usually, antimony compounds, which enhance the performance of the flame quencher. The flame-retarding action of ERA could be divided into physical and chemical actions. Physical action includes cooling, barrier action via the formed protective layer and fuel dilution. For the cooling action, flame retardants absorb the heat when they decompose, and the endothermic decomposition may consume the released heat from the combustion of ERA, then the burning adhesive is cooled. Generally, most inorganic-hydrated compounds, such as aluminium and magnesium hydroxides, may play a role via this mode. For the barrier action, the decomposition products of some flame retardants shield the surface of the adhesive and form a protective layer that may act as a barrier to resist oxygen and the produced heat. Consequently, the burning process is difficult to sustain. For fuel dilution, some flame retardants may release water vapour, carbon dioxide, or other inert gases, thereby decreasing the concentration of free radicals and combustible gases in the burning adhesive. Chemical action includes gas-phase and condensed-phase reactions. The gas-phase reaction mechanism is generally regarded as the interruption of the chain reaction of the ERA structural system during burning. The flame retardant that provides the flame-retarding action via the gas-phase reaction action may capture free radicals to decrease the concentration of free radicals than the combustion threshold and then prevent or delay burning, in which halogen-containing flame retardants are the most representative. During burning, the halogen-containing flame retardants release the hydrogen halide, which may react with the free radicals formed during burning to inhibit the combustion of substrates. For the condensed-phase reaction, the flame retardant that provides the flame-retarding action via the condensed-phase reaction may promote the formation of a carbonised or vitreous layer by cross-linking, aromatising, catalytic dehydration of polymers or reacting with the ERA. In this flame-retardant mode, intumescent flame retardants may form an intumescent char layer by some chemical reactions during burning, and generally, the formed char layer may promote the barrier action and improve the flame retardancy of the ERA. Furthermore, some flame retardants can accelerate the rupture of the chains of the ERA, and several droplets are produced under this condition. Then, a large amount of heat may be taken away when these droplets move away from the burning zone [44]. Flame retardants can be classified into several families, including halogen-based compounds, phosphorus-based compounds, silicon-based compounds, nano-composites and metal-based compounds. Among them, halogen-based and phosphorus-based flame retardants are widely used.
For halogen-containing flame retardants, the flammability of ERA can be greatly reduced by incorporating a halogen into the molecule. The best known are the halogen-containing ERAs based on chlorinated, brominated and fluorinated bisphenol A. They often comprise blends of two or more epoxy-resin systems, one of which is a halogenated resin, and the other of which perhaps contains a halogenated curing agent, such as chloric anhydride. These halogen-containing ERAs have been developed over decades and are still used widely due to the obvious advantages of low cost, processability, miscibility and low reduction in physical/mechanical features of the flame-retardant systems. Halogen-containing flame retardants function by liberating acid halide gases as the product thermally breaks down at the high temperatures incurred in a fire. These halide gases act as extinguishers to significantly increase the ignition temperature of the cured ERA. The mechanism of these flame retardants is the release of hydrogen halides (HCl and HBr) during the thermal decomposition of the ERA. The chemical reaction during burning is a free radical chain reaction, and the continuous growth of free radicals is important for maintaining the burning process for the ERA. Several chemical halide intermediates form during the burning of ERAs. These halide species are carried into the flame front of the burning polymer where they inhibit key free radical reactions of combustion. This inhibition results in flames becoming unsteady and extinguishing and lowers the release of heat overall [10, 11]. Generally, alicyclic or aliphatic halogen-containing flame retardants are more efficient than aromatic halogen compounds. Alicyclic or aliphatic halogen-containing flame retardants burn at low temperatures for most polyolefins because of lower carbon-halogen bond energies and easier halogen release [45]. Beach et al. [46] synthesised brominated polybutadiene-polystyrene (BrPBPS) flame retardant from styrene-butadiene-styrene triblock architecture by bromination. The BrPBPS flame retardant contains similar aliphatic bromine as in hexabromocyclododecane, but with a higher-molecular-weight structure. It provides similar flame-retardant activity as hexabromocyclododecane in polystyrene blends, where both release HBr to provide the gas-phase activity. Both also provide enhanced ERA degradation as another major pathway for condensed flame-retardant activity. Jiang et al. [47] added BrPBPS into epoxy asphalt adhesive to enhance its flame resistance. Meanwhile, the Tg of the epoxy asphalt adhesive was notably enhanced with the inclusion of BrPBPS. Wu et al. [48] synthesised liquid-oxygen-compatible bromine-containing ERA by the polycondensation of tetrabromobisphenol A and epoxy resins. The bromine element was introduced into the ERA to improve the liquid oxygen compatibility and enhance flame retardancy. The results showed that limiting oxygen index increased drastically when the bromine content was increased from 0% to 21.20%.
Phosphorus-containing flame retardants are identified as one of the most promising halogen-free flame retardants [49, 50] since they possess excellent properties, such as low-smoke emission, low toxicity, form a stable carbonised layer after burning effectively [44, 46, 51, 52] and are environmentally friendly [35]. For preparing organophosphorus epoxides-based adhesive, three general methods were employed. First, the condensation of 1-chloro-2,3-epoxypropane and organophosphorus compounds containing two or more hydroxyl groups. Second, the Michaelis-Arbuzov reaction of phosphites with 1-halogeno-2,3-epoxypropanes. Finally, the epoxidation of tertiary phosphine oxides by peroxy acids [53]. Phosphorus-containing flame retardants can be generally classified into three categories: (1) simple reactive phosphate monomers; (2) linear polyphosphazenes; (3) aromatic cyclic phosphazenes. They may be integrated into the ERA chains through co-polymerisation, homo-polymerisation, surface modification or blending; simple inorganic or organic additives are excluded [25, 53, 54, 55]. During the burning of ERAs, most of the current phosphorus-containing flame retardants may act simultaneously in the condensed and gaseous phases [56]. In the condensed phase, phosphorous-containing flame retardants can make the amount of carbonaceous residue or char, which acts as the thermal insulation, and a barrier of oxygen to transfer to the burning adhesive increase. Afterwards, a carbonised layer is formed. The carbonised layer prevents further pyrolysis of the corresponding ERA [57]. In the gaseous phase, some phosphorus-based additive flame retardants may produce several free radicals during the thermal decomposition process, and they may react with the free radicals which are generated from the ERA. Then, the free-radicals-supported combustion of polymers might be stopped due to the lack of fuel [58, 59, 60]. Wazarkar et al. [61] synthesised phosphorus–sulphur-containing di and tetra functional carboxyl curing agents and used them in preparing high-performance ERA and coating. The anticorrosive and flame-retardant properties of the adhesives and coatings were improved as the concentration of the flame-retardant-curing agents increased, and they exhibited excellent mechanical and chemical properties and thermal stability. Ma et al. [62] synthesised a phosphorus-containing bio-based ERA from itaconic acid and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide. As the matrix, its cured epoxy network with methyl hexahydrophthalic anhydride as the curing agent showed comparable Tg and mechanical properties to diglycidyl ether in a bisphenol A system, as well as good flame retardancy with UL94 V-0 grade during a vertical burning test.
ERA is often used mainly because it has the advantages of low-temperature curing, good bonding performance and improved engineering efficiency. ERAs are usually used for metal bonding, concrete bonding and wood adhesive.
Several studies have been conducted on the use of ERAs for metal bonding. In a previous study, polyurethane 1,2-polyethylene oxide was first cured onto the metal surface and then used 1,1-polyoxyethylene ether. The adhesive adheres the polyurethane resin material to the metal [63]. Subsequently, another study prepared a novel high-temperature curing epoxy adhesive using polysulfone as a raw material. Studies have shown that the tackifier resin accelerates the bonding of ERA and steel and promotes the bonding and vulcanisation of fluorine rubber [64]. Uehara et al. [65] prepared a monolithic ERA layer with a porous structure on the surface of a stainless steel (SUS) plate through a polymerisation-induced phase separation process, as a mediator for bonding SUS and various thermoplastic resin plates. The research results show that the bond strength of the apparent bond area between SUS and ERA is two to three times higher than those for direct metal-resin bonding.
Concrete is the most widely used worldwide building material. Traditional cement is used as a binding material for concrete. Cement concrete also has some shortcomings, such as low tensile and flexural strength, high porosity, low durability and abrasion resistance and longer solidification time. The mechanism of epoxy concrete is such that ERA forms a 3D structure through cross-linking in the combination of masonry mortar and concrete [66]. Afterwards, the ERA particles are dispersed into the system. Then, a part of the adhesive particles settle on the surface of the aggregate particles and participate in the cross-linking reaction. Finally, the ERA particles form a cured network structure, and the aggregates are bonded in the cured epoxy network structure. In ERA/mortar/concrete composites, the adhesive network forms a bridge between aggregates, so that the epoxy-based composites have higher mechanical properties and impermeability [67]. Also, it was found that the resin bond concrete has great advantages in the manufacture of machine tool beds. Kim et al. [68] studied ERA as the matrix material of resin concrete. The reinforced aggregate of resin concrete comprises pebbles and sand. The results showed that when the mass fraction of resin in the resin concrete is 7.5%, the thermal expansion coefficient of the resin concrete is the same as that of cast iron. In this case, the specific heat of resin concrete is 63% larger than that of cast iron. Beutel et al. [69] added epoxy resin-based adhesive concrete and coarse aggregate to the mixture and found that adding the aggregate did not affect the strength of the mixture. Additionally, the specimens exhibited much higher tensile and flexural strength than ordinary concrete, and the compressive strength was similar to ordinary high-strength concrete.
Lei et al. [70] modified soy protein isolate with a surfactant grafted with maleic anhydride and blended with epoxy resin to prepare wood adhesives with higher bonding strength and good water resistance. Zhang et al. [71, 72, 73] prepared wood adhesive with good water and heat resistance by the co-polycondensation of tannin or lignin or starch with furfuryl alcohol and blending with epoxy resin. After bonding with wood, the adhesive was cured at high temperature under pressing to prepare a wood-based panel. After testing, the material showed good shear strength.
Although research activities on modifying ERAs have greatly progressed, several problems still need urgent resolution. For example, most of the toughening methods of ERAs are at the expense of the rigidity and strength of the modified product, and it is difficult to increase the toughness and strength of the ERA simultaneously. The ERA modified with rubber or nano-particles, due to the large specific surface area of nano-particles or rubber, is very easy to agglomerate. Therefore, how to uniformly disperse it in the ERA system to obtain a reinforced and toughened high-performance ERA remains an important research topic. Therefore, the future development direction of ERAs should be towards low-temperature fast curing, high performance, green environmental protection and multifunctional development. ERAs have developed in a more stable, safe and scientific direction.
This work was supported by The Yunnan Provincial Natural Science Foundation (Grant No. 202101AT070038, 2018FG001095), and the Yunnan Provincial Youth top talent project (YNWR-QNBJ-2020-166) and Youth talent support project and Middle-age Reserve Talents of Academic and Technical Leaders (2019HB026) and the 111 project (D21027).
The authors declared that they have no conflicts of interest.
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He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. 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In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"26",type:"subseries",title:"Machine Learning and Data Mining",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11422,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",slug:"ciza-thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}},{id:"16614",title:"Prof.",name:"Juan Ignacio",middleName:null,surname:"Guerrero Alonso",slug:"juan-ignacio-guerrero-alonso",fullName:"Juan Ignacio Guerrero Alonso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6HB8QAM/Profile_Picture_1627901127555",institutionString:null,institution:{name:"University of Seville",institutionURL:null,country:{name:"Spain"}}},{id:"3095",title:"Prof.",name:"Kenji",middleName:null,surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/3095/images/1592_n.jpg",institutionString:null,institution:{name:"University of Chicago",institutionURL:null,country:{name:"United States of America"}}},{id:"214067",title:"Dr.",name:"W. 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. 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