Rafael Moreno-Gómez-Toledano

University of Alcalá

Awarded his Machelor's degree in Biology, Master's degree in Cellular Signaling, and Ph.D. from the University of Alcalá (Madrid, Spain). Specialist in Endocrine Disruptors, most of his research career has focused on the effects of bisphenol A (BPA) on the renal and cardiovascular systems. His early work demonstrated that BPA at low concentrations could induce mouse podocyte hypertrophy and apoptosis as well as hypertension in mice treated orally. At the same time, he worked with the Cultural Studies Research Group (GIMEC, for its acronym in Spanish) of the European Center for the Diffusion of Social Sciences, developing lines of research on non-human culture. Later, he worked on an experimental animal model of diabetes in which it was observed that BPA, at doses lower than the renal NOAEL (no observed adverse effect level), had a potentiating effect on diabetic nephropathy (DN). In non-diabetic animals, the same dose caused lesions similar to early DN. In experiments with human podocytes in culture, he observed that low doses of BPA could affect the structural integrity and cellular adhesion capacity. Subsequent work at the cardiovascular level demonstrated that BPA is also involved in cellular necroptosis and the acceleration of cellular aging in the context of vascular endothelium. His latest work has determined new associations between emerging bisphenols that replace BPA (such as BPF or BPS) and diabetes and renal and cardiovascular pathologies. Currently, he works at the Ramón y Cajal Hospital investigating miRNAs in the context of cardiovascular diseases as possible new diagnostic and disease progression prediction tools.

Rafael Moreno-Gómez-Toledano

3chapters authored