Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\n
This achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\n
We are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\n
Thank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"66",leadTitle:null,fullTitle:"Advances in Sound Localization",title:"Advances in Sound Localization",subtitle:null,reviewType:"peer-reviewed",abstract:"Sound source localization is an important research field that has attracted researchers’ efforts from many technical and biomedical sciences. Sound source localization (SSL) is defined as the determination of the direction from a receiver, but also includes the distance from it. \r\nBecause of the wave nature of sound propagation, phenomena such as refraction, diffraction, diffusion, reflection, reverberation and interference occur. The wide spectrum of sound frequencies that range from infrasounds through acoustic sounds to ultrasounds, also introduces difficulties, as different spectrum components have different penetration properties through the medium. Consequently, SSL is a complex computation problem and development of robust sound localization techniques calls for different approaches, including multisensor schemes, null-steering beamforming and time-difference arrival techniques. The book offers a rich source of valuable material on advances on SSL techniques and their applications that should appeal to researches representing diverse engineering and scientific disciplines.",isbn:null,printIsbn:"978-953-307-224-1",pdfIsbn:"978-953-51-4503-5",doi:"10.5772/597",price:159,priceEur:175,priceUsd:205,slug:"advances-in-sound-localization",numberOfPages:606,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"3d2ef1f3f506c287ecd134041c20952c",bookSignature:"Pawel Strumillo",publishedDate:"April 11th 2011",coverURL:"https://cdn.intechopen.com/books/images_new/66.jpg",numberOfDownloads:73576,numberOfWosCitations:81,numberOfCrossrefCitations:37,numberOfCrossrefCitationsByBook:8,numberOfDimensionsCitations:79,numberOfDimensionsCitationsByBook:8,hasAltmetrics:1,numberOfTotalCitations:197,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 12th 2010",dateEndSecondStepPublish:"June 9th 2010",dateEndThirdStepPublish:"September 14th 2010",dateEndFourthStepPublish:"November 13th 2010",dateEndFifthStepPublish:"January 27th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"20143",title:"Prof.",name:"Pawel",middleName:null,surname:"Strumillo",slug:"pawel-strumillo",fullName:"Pawel Strumillo",profilePictureURL:"https://mts.intechopen.com/storage/users/20143/images/1570_n.jpg",biography:"Pawel Strumillo received the Ph.D. degree in technical sciences from the University of Strathclyde, Glasgow, U.K. in 1993, and D.Sc. degree (habilitation) in electronics from the Technical University of Lodz (TUL), Poland in 2002. Currently, he holds the position of professor at TUL and is the head of the Medical Electronics Division. His research interests include: processing of biomedical and acoustic signal, computational intelligence and human-computer interaction systems. He has authored more than 100 publications in these fields. He has been principal and co-principal investigator of research grants on electronic systems aiding the blind in independent travel. Results of these projects were awarded at international innovation exhibitions. He has also received a number of industry grants from the Orange Telecommunications Group. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and member of board of the Polish Neural Network Society.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Lodz University of Technology",institutionURL:null,country:{name:"Poland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"810",title:"Acoustical Engineering",slug:"mechanical-engineering-acoustical-engineering"}],chapters:[{id:"15106",title:"The Linear Method for Acoustical Source Localization (Constant Speed Localization Method) - A Discussion of Receptor Geometries and Time Delay Accuracy for Robust Localization",doi:"10.5772/14663",slug:"the-linear-method-for-acoustical-source-localization-constant-speed-localization-method-a-discussion",totalDownloads:2368,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Sergio R. Buenafuente and Carmelo M. Militello",downloadPdfUrl:"/chapter/pdf-download/15106",previewPdfUrl:"/chapter/pdf-preview/15106",authors:[{id:"18469",title:"Dr.",name:"Sergio R.",surname:"Buenafuente",slug:"sergio-r.-buenafuente",fullName:"Sergio R. Buenafuente"},{id:"20420",title:"Dr.",name:"Carmelo M.",surname:"Militello",slug:"carmelo-m.-militello",fullName:"Carmelo M. Militello"}],corrections:null},{id:"15107",title:"Direction-Selective Filters for Sound Localization",doi:"10.5772/15920",slug:"direction-selective-filters-for-sound-localization",totalDownloads:2071,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:null,signatures:"Dean Schmidlin",downloadPdfUrl:"/chapter/pdf-download/15107",previewPdfUrl:"/chapter/pdf-preview/15107",authors:[{id:"22472",title:"Dr.",name:"Dean",surname:"Schmidlin",slug:"dean-schmidlin",fullName:"Dean Schmidlin"}],corrections:null},{id:"15108",title:"Single-Channel Sound Source Localization Based on Discrimination of Acoustic Transfer Functions",doi:"10.5772/14187",slug:"single-channel-sound-source-localization-based-on-discrimination-of-acoustic-transfer-functions",totalDownloads:2110,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Ryoichi Takashima, Tetsuya Takiguchi and Yasuo Ariki",downloadPdfUrl:"/chapter/pdf-download/15108",previewPdfUrl:"/chapter/pdf-preview/15108",authors:[{id:"2093",title:"Dr.",name:"Tetsuya",surname:"Takiguchi",slug:"tetsuya-takiguchi",fullName:"Tetsuya Takiguchi"},{id:"5503",title:"Dr.",name:"Yasuo",surname:"Ariki",slug:"yasuo-ariki",fullName:"Yasuo Ariki"},{id:"17095",title:"Mr.",name:"Ryoichi",surname:"Takashima",slug:"ryoichi-takashima",fullName:"Ryoichi Takashima"}],corrections:null},{id:"15109",title:"Localization Error: Accuracy and Precision of Auditory Localization",doi:"10.5772/15652",slug:"localization-error-accuracy-and-precision-of-auditory-localization",totalDownloads:3648,totalCrossrefCites:6,totalDimensionsCites:16,hasAltmetrics:0,abstract:null,signatures:"Tomasz Letowski and Szymon Letowski",downloadPdfUrl:"/chapter/pdf-download/15109",previewPdfUrl:"/chapter/pdf-preview/15109",authors:[{id:"21507",title:"Dr.",name:"Tomasz",surname:"Letowski",slug:"tomasz-letowski",fullName:"Tomasz Letowski"},{id:"26222",title:"Mr.",name:"Szymon",surname:"Letowski",slug:"szymon-letowski",fullName:"Szymon Letowski"}],corrections:null},{id:"15110",title:"HRTF Sound Localization",doi:"10.5772/14773",slug:"hrtf-sound-localization",totalDownloads:3169,totalCrossrefCites:7,totalDimensionsCites:6,hasAltmetrics:0,abstract:null,signatures:"Martin Rothbucher, David Kronmüller, Marko Durkovic, Tim Habigt and Klaus Diepold",downloadPdfUrl:"/chapter/pdf-download/15110",previewPdfUrl:"/chapter/pdf-preview/15110",authors:[{id:"17444",title:"Prof.",name:"Klaus",surname:"Diepold",slug:"klaus-diepold",fullName:"Klaus Diepold"},{id:"17910",title:"Mr.",name:"Martin",surname:"Rothbucher",slug:"martin-rothbucher",fullName:"Martin Rothbucher"},{id:"20902",title:"Mr.",name:"David",surname:"Kronmüller",slug:"david-kronmuller",fullName:"David Kronmüller"},{id:"20903",title:"Mr.",name:"Marko",surname:"Durkovic",slug:"marko-durkovic",fullName:"Marko Durkovic"},{id:"25279",title:"Mr.",name:"Tim",surname:"Habigt",slug:"tim-habigt",fullName:"Tim Habigt"}],corrections:null},{id:"15111",title:"Effect of Space on Auditory Temporal Processing with a Single-Stimulus Method",doi:"10.5772/14436",slug:"effect-of-space-on-auditory-temporal-processing-with-a-single-stimulus-method",totalDownloads:2207,totalCrossrefCites:4,totalDimensionsCites:6,hasAltmetrics:0,abstract:null,signatures:"Martin Roy, Tsuyoshi Kuroda and Simon Grondin",downloadPdfUrl:"/chapter/pdf-download/15111",previewPdfUrl:"/chapter/pdf-preview/15111",authors:[{id:"17780",title:"Dr.",name:"Simon",surname:"Grondin",slug:"simon-grondin",fullName:"Simon Grondin"}],corrections:null},{id:"15112",title:"Sound Source Localization Method Using Region Selection",doi:"10.5772/15645",slug:"sound-source-localization-method-using-region-selection",totalDownloads:2229,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Yong-Eun Kim, Dong-Hyun Su, Chang-Ha Jeon, Jae-Kyung Lee, Kyung-Ju Cho and Jin-Gyun Chung",downloadPdfUrl:"/chapter/pdf-download/15112",previewPdfUrl:"/chapter/pdf-preview/15112",authors:[{id:"21252",title:"Dr.",name:"Yong En",surname:"Kim",slug:"yong-en-kim",fullName:"Yong En Kim"},{id:"26965",title:"Dr.",name:"Yong-Eun",surname:"Kim",slug:"yong-eun-kim",fullName:"Yong-Eun Kim"},{id:"26966",title:"Mr.",name:"Dong-Hyun",surname:"Su",slug:"dong-hyun-su",fullName:"Dong-Hyun Su"},{id:"26967",title:"Prof.",name:"Jin-Gyun",surname:"Chung",slug:"jin-gyun-chung",fullName:"Jin-Gyun Chung"},{id:"26989",title:"Dr.",name:"Chul-Dong",surname:"LEE",slug:"chul-dong-lee",fullName:"Chul-Dong LEE"}],corrections:null},{id:"15113",title:"Robust Audio Localization for Mobile Robots in Industrial Environments",doi:"10.5772/14517",slug:"robust-audio-localization-for-mobile-robots-in-industrial-environments",totalDownloads:2121,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Manuel Manzanares, Yolanda Bolea and Antoni Grau",downloadPdfUrl:"/chapter/pdf-download/15113",previewPdfUrl:"/chapter/pdf-preview/15113",authors:[{id:"17971",title:"Prof.",name:"Antoni",surname:"Grau",slug:"antoni-grau",fullName:"Antoni Grau"},{id:"18024",title:"Dr.",name:"Yolanda",surname:"Bolea",slug:"yolanda-bolea",fullName:"Yolanda Bolea"},{id:"18025",title:"Mr.",name:"Manuel",surname:"Manzanares",slug:"manuel-manzanares",fullName:"Manuel Manzanares"}],corrections:null},{id:"15114",title:"Source Localization for Dual Speech Enhancement Technology",doi:"10.5772/14524",slug:"source-localization-for-dual-speech-enhancement-technology",totalDownloads:2809,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Seungil Kim, Hyejeong Jeon, and Lag-Young Kim",downloadPdfUrl:"/chapter/pdf-download/15114",previewPdfUrl:"/chapter/pdf-preview/15114",authors:[{id:"17122",title:"Dr.",name:"Lag-Young",surname:"Kim",slug:"lag-young-kim",fullName:"Lag-Young Kim"},{id:"18051",title:"Prof.",name:"Seungil",surname:"Kim",slug:"seungil-kim",fullName:"Seungil Kim"},{id:"20642",title:"Dr.",name:"Hyejeong",surname:"Jeon",slug:"hyejeong-jeon",fullName:"Hyejeong Jeon"}],corrections:null},{id:"15115",title:"Underwater Acoustic Source Localization and Sounds Classification in Distributed Measurement Networks",doi:"10.5772/15487",slug:"underwater-acoustic-source-localization-and-sounds-classification-in-distributed-measurement-network",totalDownloads:5200,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Octavian Adrian Postolache, José Miguel Pereira and Pedro Silva Girão",downloadPdfUrl:"/chapter/pdf-download/15115",previewPdfUrl:"/chapter/pdf-preview/15115",authors:[{id:"8384",title:"Prof.",name:"Jose Miguel",surname:"Pereira",slug:"jose-miguel-pereira",fullName:"Jose Miguel Pereira"}],corrections:null},{id:"15116",title:"Using Virtual Acoustic Space to Investigate Sound Localisation",doi:"10.5772/14193",slug:"using-virtual-acoustic-space-to-investigate-sound-localisation",totalDownloads:2324,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Laura Hausmann and Hermann Wagner",downloadPdfUrl:"/chapter/pdf-download/15116",previewPdfUrl:"/chapter/pdf-preview/15116",authors:[{id:"17115",title:"Dr.",name:"Laura",surname:"Hausmann",slug:"laura-hausmann",fullName:"Laura Hausmann"},{id:"20231",title:"Dr.",name:"Hermann",surname:"Wagner",slug:"hermann-wagner",fullName:"Hermann Wagner"}],corrections:null},{id:"15117",title:"Sound Waves Generated Due to the Absorption of a Pulsed Electron Beam",doi:"10.5772/15273",slug:"sound-waves-generated-due-to-the-absorption-of-a-pulsed-electron-beam",totalDownloads:1774,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:null,signatures:"A. Pushkarev, J. Isakova, G. Kholodnaya and R. Sazonov",downloadPdfUrl:"/chapter/pdf-download/15117",previewPdfUrl:"/chapter/pdf-preview/15117",authors:[{id:"16432",title:"Dr.",name:"Alexander",surname:"Pushkarev",slug:"alexander-pushkarev",fullName:"Alexander Pushkarev"},{id:"137128",title:"Ms.",name:"Yulia",surname:"Isakova",slug:"yulia-isakova",fullName:"Yulia Isakova"},{id:"137129",title:"Prof.",name:"Galina",surname:"Kholodnaya",slug:"galina-kholodnaya",fullName:"Galina Kholodnaya"},{id:"137130",title:"Prof.",name:"Roman",surname:"Sazonov",slug:"roman-sazonov",fullName:"Roman Sazonov"}],corrections:null},{id:"15118",title:"Spatial Audio Applied to Research with the Blind",doi:"10.5772/15206",slug:"spatial-audio-applied-to-research-with-the-blind",totalDownloads:3442,totalCrossrefCites:2,totalDimensionsCites:16,hasAltmetrics:0,abstract:null,signatures:"Brian FG Katz and Lorenzo Picinali",downloadPdfUrl:"/chapter/pdf-download/15118",previewPdfUrl:"/chapter/pdf-preview/15118",authors:[{id:"19955",title:"Dr.",name:"Lorenzo",surname:"Picinali",slug:"lorenzo-picinali",fullName:"Lorenzo Picinali"},{id:"278731",title:"Dr.",name:"Brian FG",surname:"Katz",slug:"brian-fg-katz",fullName:"Brian FG Katz"}],corrections:null},{id:"15119",title:"Sonification of 3D Scenes in an Electronic Travel Aid for the Blind",doi:"10.5772/15311",slug:"sonification-of-3d-scenes-in-an-electronic-travel-aid-for-the-blind",totalDownloads:2253,totalCrossrefCites:4,totalDimensionsCites:5,hasAltmetrics:0,abstract:null,signatures:"Michal Bujacz, Michal Pec, Piotr Skulimowski, Pawel Strumillo and Andrzej Materka",downloadPdfUrl:"/chapter/pdf-download/15119",previewPdfUrl:"/chapter/pdf-preview/15119",authors:[{id:"20143",title:"Prof.",name:"Pawel",surname:"Strumillo",slug:"pawel-strumillo",fullName:"Pawel Strumillo"},{id:"20672",title:"Prof.",name:"Andrzej",surname:"Materka",slug:"andrzej-materka",fullName:"Andrzej Materka"},{id:"20673",title:"Dr.",name:"Piotr",surname:"Skulimowski",slug:"piotr-skulimowski",fullName:"Piotr Skulimowski"},{id:"20674",title:"Mr.",name:"Michal",surname:"Pec",slug:"michal-pec",fullName:"Michal Pec"},{id:"20675",title:"Mr.",name:"Michal",surname:"Bujacz",slug:"michal-bujacz",fullName:"Michal Bujacz"}],corrections:null},{id:"15120",title:"Virtual Moving Sound Source Localization through Headphones",doi:"10.5772/14643",slug:"virtual-moving-sound-source-localization-through-headphones",totalDownloads:2756,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Larisa Dunai, Guillermo Peris-Fajarnés, Teresa Magal-Royo, Beatriz Defez and Victor Santiago Praderas",downloadPdfUrl:"/chapter/pdf-download/15120",previewPdfUrl:"/chapter/pdf-preview/15120",authors:[{id:"18427",title:"Dr.",name:"Larisa",surname:"Dunai",slug:"larisa-dunai",fullName:"Larisa Dunai"},{id:"20169",title:"Dr.",name:"Teresa",surname:"Magal Royo",slug:"teresa-magal-royo",fullName:"Teresa Magal Royo"},{id:"20170",title:"Dr.",name:"Beatriz",surname:"Defez Garcia",slug:"beatriz-defez-garcia",fullName:"Beatriz Defez Garcia"},{id:"20171",title:"Dr.",name:"Guillermo",surname:"Peris Fajarnes",slug:"guillermo-peris-fajarnes",fullName:"Guillermo Peris Fajarnes"},{id:"86118",title:"Dr.",name:"Victor Santiago",surname:"Praderas",slug:"victor-santiago-praderas",fullName:"Victor Santiago Praderas"}],corrections:null},{id:"15121",title:"Unilateral Versus Bilateral Hearing Aid Fittings",doi:"10.5772/15690",slug:"unilateral-versus-bilateral-hearing-aid-fittings",totalDownloads:4059,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Monique Boymans and Wouter A. Dreschler",downloadPdfUrl:"/chapter/pdf-download/15121",previewPdfUrl:"/chapter/pdf-preview/15121",authors:[{id:"21626",title:"Dr.",name:"Monique",surname:"Boymans",slug:"monique-boymans",fullName:"Monique Boymans"},{id:"21628",title:"Dr.",name:"Wouter A.",surname:"Dreschler",slug:"wouter-a.-dreschler",fullName:"Wouter A. Dreschler"}],corrections:null},{id:"15122",title:"Auditory Guided Arm and Whole Body Movements in Young Infants",doi:"10.5772/14590",slug:"auditory-guided-arm-and-whole-body-movements-in-young-infants",totalDownloads:2192,totalCrossrefCites:4,totalDimensionsCites:8,hasAltmetrics:0,abstract:null,signatures:"Audrey L.H. van der Meer and F.R. (Ruud) van der Weel",downloadPdfUrl:"/chapter/pdf-download/15122",previewPdfUrl:"/chapter/pdf-preview/15122",authors:[{id:"18261",title:"Prof.",name:"Audrey L.H.",surname:"Van Der Meer",slug:"audrey-l.h.-van-der-meer",fullName:"Audrey L.H. Van Der Meer"},{id:"53962",title:"Prof.",name:"Ruud",surname:"Van Der Weel",slug:"ruud-van-der-weel",fullName:"Ruud Van Der Weel"}],corrections:null},{id:"15123",title:"Camera Pointing with Coordinate-Free Localization and Tracking",doi:"10.5772/15310",slug:"camera-pointing-with-coordinate-free-localization-and-tracking",totalDownloads:1848,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Evan Ettinger and Yoav Freund",downloadPdfUrl:"/chapter/pdf-download/15123",previewPdfUrl:"/chapter/pdf-preview/15123",authors:[{id:"20304",title:"Dr.",name:"Evan",surname:"Ettinger",slug:"evan-ettinger",fullName:"Evan Ettinger"},{id:"20305",title:"Prof.",name:"Yoav",surname:"Freund",slug:"yoav-freund",fullName:"Yoav Freund"}],corrections:null},{id:"15124",title:"Sound Image Localization on Flat Display Panels",doi:"10.5772/14823",slug:"sound-image-localization-on-flat-display-panels",totalDownloads:2353,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Gabriel Pablo Nava, Yoshinari Shirai, Kaji Katsuhiko, Masafumi Matsuda, Keiji Hirata and Shigemi Aoyagi",downloadPdfUrl:"/chapter/pdf-download/15124",previewPdfUrl:"/chapter/pdf-preview/15124",authors:[{id:"18843",title:"Dr.",name:"Gabriel Pablo",surname:"Nava",slug:"gabriel-pablo-nava",fullName:"Gabriel Pablo Nava"},{id:"19785",title:"Dr.",name:"Yoshinari",surname:"Shirai",slug:"yoshinari-shirai",fullName:"Yoshinari Shirai"},{id:"19786",title:"Dr.",name:"Keiji",surname:"Hirata",slug:"keiji-hirata",fullName:"Keiji Hirata"}],corrections:null},{id:"15125",title:"Backward Compatible Spatialized Teleconferencing based on Squeezed Recordings",doi:"10.5772/14413",slug:"backward-compatible-spatialized-teleconferencing-based-on-squeezed-recordings",totalDownloads:2010,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Christian H. Ritz, Muawiyath Shujau, Xiguang Zheng, Bin Cheng, Eva Cheng and Ian S Burnett",downloadPdfUrl:"/chapter/pdf-download/15125",previewPdfUrl:"/chapter/pdf-preview/15125",authors:[{id:"17733",title:"Dr.",name:"Christian H.",surname:"Ritz",slug:"christian-h.-ritz",fullName:"Christian H. Ritz"},{id:"20758",title:"Mr.",name:"Bin",surname:"Cheng",slug:"bin-cheng",fullName:"Bin Cheng"},{id:"20759",title:"Ms.",name:"Eva",surname:"Cheng",slug:"eva-cheng",fullName:"Eva Cheng"},{id:"20760",title:"Mr.",name:"Muawiyath",surname:"Shujau",slug:"muawiyath-shujau",fullName:"Muawiyath Shujau"},{id:"20761",title:"Mr.",name:"Xiguang",surname:"Zheng",slug:"xiguang-zheng",fullName:"Xiguang Zheng"},{id:"20762",title:"Prof.",name:"Ian S.",surname:"Burnett",slug:"ian-s.-burnett",fullName:"Ian S. Burnett"}],corrections:null},{id:"15126",title:"Neurophysiological Correlate of Binaural Auditory Filter Bandwidth and Localization Performance Studied by Auditory Evoked Fields",doi:"10.5772/15137",slug:"neurophysiological-correlate-of-binaural-auditory-filter-bandwidth-and-localization-performance-stud",totalDownloads:1749,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Yoshiharu Soeta and Seiji Nakagawa",downloadPdfUrl:"/chapter/pdf-download/15126",previewPdfUrl:"/chapter/pdf-preview/15126",authors:[{id:"17277",title:"Dr.",name:"Yoshiharu",surname:"Soeta",slug:"yoshiharu-soeta",fullName:"Yoshiharu Soeta"},{id:"20342",title:"Dr.",name:"Seiji",surname:"Nakagawa",slug:"seiji-nakagawa",fullName:"Seiji Nakagawa"}],corrections:null},{id:"15127",title:"Processing of Binaural Information in Human Auditory Cortex",doi:"10.5772/14268",slug:"processing-of-binaural-information-in-human-auditory-cortex",totalDownloads:2878,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Blake W. Johnson",downloadPdfUrl:"/chapter/pdf-download/15127",previewPdfUrl:"/chapter/pdf-preview/15127",authors:[{id:"17325",title:"Dr.",name:"Blake W.",surname:"Johnson",slug:"blake-w.-johnson",fullName:"Blake W. Johnson"}],corrections:null},{id:"15128",title:"The Impact of Stochastic and Deterministic Sounds on Visual, Tactile and Proprioceptive Modalities",doi:"10.5772/14296",slug:"the-impact-of-stochastic-and-deterministic-sounds-on-visual-tactile-and-proprioceptive-modalities",totalDownloads:1954,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"J.E. Lugo, R. Doti and J. Faubert",downloadPdfUrl:"/chapter/pdf-download/15128",previewPdfUrl:"/chapter/pdf-preview/15128",authors:[{id:"17408",title:"Dr.",name:"Jocelyn",surname:"Faubert",slug:"jocelyn-faubert",fullName:"Jocelyn Faubert"},{id:"17409",title:"Dr.",name:"Jesús Eduardo",surname:"Lugo",slug:"jesus-eduardo-lugo",fullName:"Jesús Eduardo Lugo"},{id:"17410",title:"Mr.",name:"Rafael",surname:"Doti",slug:"rafael-doti",fullName:"Rafael Doti"}],corrections:null},{id:"15129",title:"Discrete Damage Modelling for Computer Aided Acoustic Emissions in Health Monitoring",doi:"10.5772/14575",slug:"discrete-damage-modelling-for-computer-aided-acoustic-emissions-in-health-monitoring",totalDownloads:1942,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Antonio Rinaldi, Gualtiero Gusmano and Silvia Licoccia",downloadPdfUrl:"/chapter/pdf-download/15129",previewPdfUrl:"/chapter/pdf-preview/15129",authors:[{id:"18198",title:"Prof.",name:"Antonio",surname:"Rinaldi",slug:"antonio-rinaldi",fullName:"Antonio Rinaldi"},{id:"24422",title:"Prof.",name:"Gualtiero",surname:"Gusmano",slug:"gualtiero-gusmano",fullName:"Gualtiero Gusmano"},{id:"24423",title:"Prof.",name:"Silvia",surname:"Licoccia",slug:"silvia-licoccia",fullName:"Silvia Licoccia"}],corrections:null},{id:"15130",title:"Comparative Analysis of Spatial Hearing of Terrestrial, Semiaquatic and Aquatic Mammals",doi:"10.5772/14566",slug:"comparative-analysis-of-spatial-hearing-of-terrestrial-semiaquatic-and-aquatic-mammals",totalDownloads:2184,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Elena Babushina and Mikhail Polyakov",downloadPdfUrl:"/chapter/pdf-download/15130",previewPdfUrl:"/chapter/pdf-preview/15130",authors:[{id:"18185",title:"Dr.",name:"Mikhail",surname:"Polyakov",slug:"mikhail-polyakov",fullName:"Mikhail Polyakov"},{id:"20030",title:"Dr.",name:"Mikhail",surname:"Polyakov",slug:"mikhail-polyakov",fullName:"Mikhail Polyakov"}],corrections:null},{id:"15131",title:"Directional Hearing in Fishes",doi:"10.5772/13892",slug:"directional-hearing-in-fishes",totalDownloads:1972,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Richard R. Fay",downloadPdfUrl:"/chapter/pdf-download/15131",previewPdfUrl:"/chapter/pdf-preview/15131",authors:[{id:"16190",title:"Prof.",name:"Richard R.",surname:"Fay",slug:"richard-r.-fay",fullName:"Richard R. Fay"}],corrections:null},{id:"15132",title:"Frequency Dependent Specialization for Processing Binaural Auditory Cues in Avian Sound Localization Circuits",doi:"10.5772/14826",slug:"frequency-dependent-specialization-for-processing-binaural-auditory-cues-in-avian-sound-localization",totalDownloads:1779,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Rei Yamada and Harunori Ohmori",downloadPdfUrl:"/chapter/pdf-download/15132",previewPdfUrl:"/chapter/pdf-preview/15132",authors:[{id:"18199",title:"Dr.",name:"Rei",surname:"Yamada",slug:"rei-yamada",fullName:"Rei Yamada"},{id:"18846",title:"Prof.",name:"Harunori",surname:"Ohmori",slug:"harunori-ohmori",fullName:"Harunori Ohmori"}],corrections:null},{id:"15133",title:"Highly Defined Whale Group Tracking by Passive Acoustic Stochastic Matched Filter",doi:"10.5772/16173",slug:"highly-defined-whale-group-tracking-by-passive-acoustic-stochastic-matched-filter",totalDownloads:1671,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Frédéric Bénard, Hervé Glotin and Pascale Giraudet",downloadPdfUrl:"/chapter/pdf-download/15133",previewPdfUrl:"/chapter/pdf-preview/15133",authors:[{id:"23522",title:"Dr.",name:"Hervé",surname:"Glotin",slug:"herve-glotin",fullName:"Hervé Glotin"},{id:"23523",title:"Prof.",name:"Pascale",surname:"Giraudet",slug:"pascale-giraudet",fullName:"Pascale Giraudet"},{id:"23524",title:"Dr.",name:"Frédéric",surname:"Bénard",slug:"frederic-benard",fullName:"Frédéric Bénard"}],corrections:null},{id:"15134",title:"Localising Cetacean Sounds for the Real-Time Mitigation and Long-Term Acoustic Monitoring of Noise",doi:"10.5772/14371",slug:"localising-cetacean-sounds-for-the-real-time-mitigation-and-long-term-acoustic-monitoring-of-noise",totalDownloads:2308,totalCrossrefCites:0,totalDimensionsCites:5,hasAltmetrics:0,abstract:null,signatures:"Michel André, Ludwig Houégnigan, Mike van der Schaar, Eric Delory, Serge Zaugg, Antonio M. Sánchez and Alex Mas",downloadPdfUrl:"/chapter/pdf-download/15134",previewPdfUrl:"/chapter/pdf-preview/15134",authors:[{id:"16283",title:"Dr.",name:"Michel",surname:"André",slug:"michel-andre",fullName:"Michel André"},{id:"17595",title:"Mr.",name:"Ludwig",surname:"Houégnigan",slug:"ludwig-houegnigan",fullName:"Ludwig Houégnigan"},{id:"17596",title:"Dr.",name:"Mike",surname:"van der Schaar",slug:"mike-van-der-schaar",fullName:"Mike van der Schaar"},{id:"17597",title:"Mr.",name:"Serge",surname:"Zaugg",slug:"serge-zaugg",fullName:"Serge Zaugg"},{id:"17598",title:"Mr.",name:"Antonio",surname:"Sánchez",slug:"antonio-sanchez",fullName:"Antonio Sánchez"},{id:"17599",title:"Mr.",name:"Alex",surname:"Mas",slug:"alex-mas",fullName:"Alex Mas"},{id:"135943",title:"Prof.",name:"Eric",surname:"Delory",slug:"eric-delory",fullName:"Eric Delory"}],corrections:null},{id:"15135",title:"Sound Localisation in Practice: An Application in Localisation of Sick Animals in Commercial Piggeries",doi:"10.5772/15298",slug:"sound-localisation-in-practice-an-application-in-localisation-of-sick-animals-in-commercial-piggerie",totalDownloads:2196,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:1,abstract:null,signatures:"Vasileios Exadaktylos, Mitchell Silva, Sara Ferrari, Marcella Guarino and Daniel Berckmans",downloadPdfUrl:"/chapter/pdf-download/15135",previewPdfUrl:"/chapter/pdf-preview/15135",authors:[{id:"20140",title:"Dr.",name:"Daniel",surname:"Berckmans",slug:"daniel-berckmans",fullName:"Daniel Berckmans"},{id:"20246",title:"Dr.",name:"Vasileios",surname:"Exadaktylos",slug:"vasileios-exadaktylos",fullName:"Vasileios Exadaktylos"},{id:"20391",title:"Mr.",name:"Mitchell",surname:"Silva",slug:"mitchell-silva",fullName:"Mitchell Silva"},{id:"20392",title:"Dr.",name:"Sara",surname:"Ferrari",slug:"sara-ferrari",fullName:"Sara Ferrari"},{id:"20393",title:"Dr.",name:"Marcella",surname:"Guarino",slug:"marcella-guarino",fullName:"Marcella Guarino"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"3661",title:"Acoustic Waves",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"acoustic-waves",bookSignature:"Don Dissanayake",coverURL:"https://cdn.intechopen.com/books/images_new/3661.jpg",editedByType:"Edited by",editors:[{id:"125705",title:"Dr.",name:"Don",surname:"Dissanayake",slug:"don-dissanayake",fullName:"Don Dissanayake"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"903",title:"Ultrasonic Waves",subtitle:null,isOpenForSubmission:!1,hash:"647c5e74bfd1e31a69e95758a9995206",slug:"ultrasonic-waves",bookSignature:"Auteliano Antunes dos Santos Júnior",coverURL:"https://cdn.intechopen.com/books/images_new/903.jpg",editedByType:"Edited by",editors:[{id:"106405",title:"Dr.",name:"Auteliano",surname:"Santos Jr.",slug:"auteliano-santos-jr.",fullName:"Auteliano Santos Jr."}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2188",title:"Modeling and Measurement Methods for Acoustic Waves and for Acoustic Microdevices",subtitle:null,isOpenForSubmission:!1,hash:"ae0f011b5180f0cc414a30ec559cb421",slug:"modeling-and-measurement-methods-for-acoustic-waves-and-for-acoustic-microdevices",bookSignature:"Marco G. Beghi",coverURL:"https://cdn.intechopen.com/books/images_new/2188.jpg",editedByType:"Edited by",editors:[{id:"41947",title:"Prof.",name:"Marco G.",surname:"Beghi",slug:"marco-g.-beghi",fullName:"Marco G. Beghi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1606",title:"Acoustic Emission",subtitle:null,isOpenForSubmission:!1,hash:"cc8b94f6002f9f928cb9224f7da17a0a",slug:"acoustic-emission",bookSignature:"Wojciech Sikorski",coverURL:"https://cdn.intechopen.com/books/images_new/1606.jpg",editedByType:"Edited by",editors:[{id:"86930",title:"Dr.",name:"Wojciech",surname:"Sikorski",slug:"wojciech-sikorski",fullName:"Wojciech Sikorski"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3518",title:"Acoustic Emission",subtitle:"Research and Applications",isOpenForSubmission:!1,hash:"eb280b2594730e4f14ca390eb2a29f72",slug:"acoustic-emission-research-and-applications",bookSignature:"Wojciech Sikorski",coverURL:"https://cdn.intechopen.com/books/images_new/3518.jpg",editedByType:"Edited by",editors:[{id:"86930",title:"Dr.",name:"Wojciech",surname:"Sikorski",slug:"wojciech-sikorski",fullName:"Wojciech Sikorski"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3121",title:"Advances in Vibration Engineering and Structural Dynamics",subtitle:null,isOpenForSubmission:!1,hash:"d33871d33d96c0a96ee0a3d0f1de6361",slug:"advances-in-vibration-engineering-and-structural-dynamics",bookSignature:"Francisco Beltran-Carbajal",coverURL:"https://cdn.intechopen.com/books/images_new/3121.jpg",editedByType:"Edited by",editors:[{id:"10444",title:"Dr.",name:"Francisco",surname:"Beltran-Carbajal",slug:"francisco-beltran-carbajal",fullName:"Francisco Beltran-Carbajal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3093",title:"Wave Propagation",subtitle:"Theories and Applications",isOpenForSubmission:!1,hash:"6aaba717814f53ebd3aa01547267c59b",slug:"wave-propagation-theories-and-applications",bookSignature:"Yi Zheng",coverURL:"https://cdn.intechopen.com/books/images_new/3093.jpg",editedByType:"Edited by",editors:[{id:"146846",title:"Dr.",name:"Yi",surname:"Zheng",slug:"yi-zheng",fullName:"Yi Zheng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"866",title:"Noise Control, Reduction and Cancellation Solutions in Engineering",subtitle:null,isOpenForSubmission:!1,hash:"7219da94d49d88629388cfcd200075ae",slug:"noise-control-reduction-and-cancellation-solutions-in-engineering",bookSignature:"Daniela Siano",coverURL:"https://cdn.intechopen.com/books/images_new/866.jpg",editedByType:"Edited by",editors:[{id:"9960",title:"Dr.",name:"Daniela",surname:"Siano",slug:"daniela-siano",fullName:"Daniela Siano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5240",title:"Advances in Noise Analysis, Mitigation and Control",subtitle:null,isOpenForSubmission:!1,hash:"929b0158c16444b60c079e02adb434b4",slug:"advances-in-noise-analysis-mitigation-and-control",bookSignature:"Noor Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/5240.jpg",editedByType:"Edited by",editors:[{id:"6371",title:"Dr.",name:"Noor",surname:"Ahmed",slug:"noor-ahmed",fullName:"Noor Ahmed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5774",title:"Underwater Acoustics",subtitle:null,isOpenForSubmission:!1,hash:"f9be56d90357c40ec87f7a9fcaa3c5cf",slug:"advances-in-underwater-acoustics",bookSignature:"Andrzej Zak",coverURL:"https://cdn.intechopen.com/books/images_new/5774.jpg",editedByType:"Edited by",editors:[{id:"16539",title:"Dr.",name:"Andrzej",surname:"Zak",slug:"andrzej-zak",fullName:"Andrzej Zak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"79243",slug:"corrigendum-to-hypoxia-angiogenesis-and-atherogenesis",title:"Corrigendum to: Hypoxia, Angiogenesis and Atherogenesis",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/79243.pdf\r\n",downloadPdfUrl:"/chapter/pdf-download/79243",previewPdfUrl:"/chapter/pdf-preview/79243",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/79243",risUrl:"/chapter/ris/79243",chapter:{id:"53523",slug:"hypoxia-angiogenesis-and-atherogenesis",signatures:"Lamia Heikal and Gordon Ferns",dateSubmitted:"September 6th 2016",dateReviewed:"November 3rd 2016",datePrePublished:null,datePublished:"April 5th 2017",book:{id:"5682",title:"Physiologic and Pathologic Angiogenesis",subtitle:"Signaling Mechanisms and Targeted Therapy",fullTitle:"Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy",slug:"physiologic-and-pathologic-angiogenesis-signaling-mechanisms-and-targeted-therapy",publishedDate:"April 5th 2017",bookSignature:"Dan Simionescu and Agneta Simionescu",coverURL:"https://cdn.intechopen.com/books/images_new/5682.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"66196",title:"Dr.",name:"Dan",middleName:"T.",surname:"Simionescu",slug:"dan-simionescu",fullName:"Dan Simionescu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"195461",title:"Dr.",name:"Lamia",middleName:null,surname:"Heikal",fullName:"Lamia Heikal",slug:"lamia-heikal",email:"l.heikal@bsms.ac.uk",position:null,institution:null},{id:"199995",title:"Prof.",name:"Gordon",middleName:null,surname:"Ferns",fullName:"Gordon Ferns",slug:"gordon-ferns",email:"g.ferns@bsms.ac.uk",position:null,institution:null}]}},chapter:{id:"53523",slug:"hypoxia-angiogenesis-and-atherogenesis",signatures:"Lamia Heikal and Gordon Ferns",dateSubmitted:"September 6th 2016",dateReviewed:"November 3rd 2016",datePrePublished:null,datePublished:"April 5th 2017",book:{id:"5682",title:"Physiologic and Pathologic Angiogenesis",subtitle:"Signaling Mechanisms and Targeted Therapy",fullTitle:"Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy",slug:"physiologic-and-pathologic-angiogenesis-signaling-mechanisms-and-targeted-therapy",publishedDate:"April 5th 2017",bookSignature:"Dan Simionescu and Agneta Simionescu",coverURL:"https://cdn.intechopen.com/books/images_new/5682.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"66196",title:"Dr.",name:"Dan",middleName:"T.",surname:"Simionescu",slug:"dan-simionescu",fullName:"Dan Simionescu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"195461",title:"Dr.",name:"Lamia",middleName:null,surname:"Heikal",fullName:"Lamia Heikal",slug:"lamia-heikal",email:"l.heikal@bsms.ac.uk",position:null,institution:null},{id:"199995",title:"Prof.",name:"Gordon",middleName:null,surname:"Ferns",fullName:"Gordon Ferns",slug:"gordon-ferns",email:"g.ferns@bsms.ac.uk",position:null,institution:null}]},book:{id:"5682",title:"Physiologic and Pathologic Angiogenesis",subtitle:"Signaling Mechanisms and Targeted Therapy",fullTitle:"Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy",slug:"physiologic-and-pathologic-angiogenesis-signaling-mechanisms-and-targeted-therapy",publishedDate:"April 5th 2017",bookSignature:"Dan Simionescu and Agneta Simionescu",coverURL:"https://cdn.intechopen.com/books/images_new/5682.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"66196",title:"Dr.",name:"Dan",middleName:"T.",surname:"Simionescu",slug:"dan-simionescu",fullName:"Dan Simionescu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11020",leadTitle:null,title:"Dietary Supplements - Challenges and Future Research",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tConcerns about food intake choices have prompted individuals to question if they are indeed meeting nutritional guidelines for good health. In the belief that they may not be meeting the required levels of nutrients, either justified or not, they take supplements as insurance towards nutrient adequacy and good health. This concept of taking supplements has gained popularity in recent years. Recognizing the potential for a business opportunity, business sectors around the globe are now offering a wide range of dietary and nutritional supplements. This increase in the intake and sales of supplements has raised serious concerns among health professionals and government regulatory agencies. Questions are now being raised as to the scientific evidence in support of supplements and possible adverse effects. Recognizing the importance of the issue of dietary supplements, this book is being published to provide current knowledge on the research that is being conducted and provide science-based opinions of the use of supplements. It is the hope of the editors and the publisher that the information provided in the chapters of this book will lead to better and safer use of supplements leading to good health.
",isbn:"978-1-80356-207-0",printIsbn:"978-1-80356-206-3",pdfIsbn:"978-1-80356-208-7",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"2283ae2d0816c17ad46cbedbe4ce5e78",bookSignature:"Dr. Venketeshwer Rao and Dr. Leticia Rao",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11020.jpg",keywords:"Dietary And Nutritional Supplements, Health, Long Term Usage, Mechanisms Of Action, Research Study Designs, Safety, Health Benefits, Concerns, Evidence-Based Recommendations, Regulatory Guideline, Current Research, Future Research",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 4th 2022",dateEndSecondStepPublish:"April 5th 2022",dateEndThirdStepPublish:"June 4th 2022",dateEndFourthStepPublish:"August 23rd 2022",dateEndFifthStepPublish:"October 22nd 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Rao is a Professor Emeritus who has pioneered research in the area of the role of phytochemicals, prebiotics, and probiotics in human health focusing on cardiovascular disease, cancer, and osteoporosis. He served as the Director of the Department of Toxicology and The Division of Food Safety and Regulatory Affairs, the University of Toronto during his academic career.",coeditorOneBiosketch:"Dr. Leticia Rao is a Professor Emeritus at the University of Toronto and a pioneering researcher with expertise in the area of bone cell biology with a goal of finding the prevention of osteoporosis. She was the Director of the Calcium Research Laboratory at the Department of Medicine, University of Toronto.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",middleName:null,surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao",profilePictureURL:"https://mts.intechopen.com/storage/users/82663/images/system/82663.jpg",biography:"Dr. Rao, Professor Emeritus, Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, has established a major focus in the area of diet and health. His research focuses on the role of oxidative stress and antioxidant phytochemicals in the causation and prevention of chronic diseases, with particular emphasis on the role of carotenoids and polyphenols. His research interests also include the role of prebiotics and probiotics in human health. He has more than 100 publications in scientific journals and several books and book chapters to his credit. He has a distinguished academic career spanning more than forty-five years. Dr. Rao is popularly sought by the international media to express his opinions about nutrition and health.",institutionString:"University of Toronto",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"7",institution:{name:"University of Toronto",institutionURL:null,country:{name:"Canada"}}}],coeditorOne:{id:"163766",title:"Dr.",name:"Leticia",middleName:null,surname:"Rao",slug:"leticia-rao",fullName:"Leticia Rao",profilePictureURL:"https://mts.intechopen.com/storage/users/163766/images/system/163766.jpg",biography:"Dr. Leticia Rao is Professor Emeritus at the University of Toronto, Ontario, former director of the Calcium Research Laboratory,\nDepartment of Medicine, University of Toronto, and former\nstaff scientist at St. Michael’s Hospital, Toronto, Ontario. She has\na BSc in Chemistry from the University of the Philippines, an\nMSc in Food Science from Oregon State University, and a Ph.D.\nin Biochemistry from the University of Toronto. Her expertise is\nin bone cell biology with a focus on preventing osteoporosis by studying bone cells\nin the laboratory and carrying out basic and clinical studies of drugs, nutritional\nsupplements, and phytonutrients including carotenoids and polyphenols in postmenopausal women. Her research has been presented at national and international\nconferences and symposia and published extensively in peer-reviewed scientific\njournals. She co-authored The Bone-Building Solution and co-edited several books\non phytochemicals and probiotics in human nutrition and health.",institutionString:"University of Toronto",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Toronto",institutionURL:null,country:{name:"Canada"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444316",firstName:"Blanka",lastName:"Gugic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/444316/images/20016_n.jpg",email:"blanka@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"878",title:"Phytochemicals",subtitle:"A Global Perspective of Their Role in Nutrition and Health",isOpenForSubmission:!1,hash:"ec77671f63975ef2d16192897deb6835",slug:"phytochemicals-a-global-perspective-of-their-role-in-nutrition-and-health",bookSignature:"Venketeshwer Rao",coverURL:"https://cdn.intechopen.com/books/images_new/878.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1958",title:"Phytochemicals as Nutraceuticals",subtitle:"Global Approaches to Their Role in Nutrition and Health",isOpenForSubmission:!1,hash:"7a4d422838dabdc758119a7dfc6e7a54",slug:"phytochemicals-as-nutraceuticals-global-approaches-to-their-role-in-nutrition-and-health",bookSignature:"Venketeshwer Rao",coverURL:"https://cdn.intechopen.com/books/images_new/1958.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4528",title:"Phytochemicals",subtitle:"Isolation, Characterisation and Role in Human Health",isOpenForSubmission:!1,hash:"2d32f26b4936bc0cdca01c74bce1a6ec",slug:"phytochemicals-isolation-characterisation-and-role-in-human-health",bookSignature:"A. Venket Rao and Leticia G. Rao",coverURL:"https://cdn.intechopen.com/books/images_new/4528.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5193",title:"Probiotics and Prebiotics in Human Nutrition and Health",subtitle:null,isOpenForSubmission:!1,hash:"facfb45c80773cd5151d8f53b902be39",slug:"probiotics-and-prebiotics-in-human-nutrition-and-health",bookSignature:"Venketeshwer Rao and Leticia G. Rao",coverURL:"https://cdn.intechopen.com/books/images_new/5193.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8077",title:"Phytochemicals in Human Health",subtitle:null,isOpenForSubmission:!1,hash:"8db73d87975ed16ea4758f1aecb5bf27",slug:"phytochemicals-in-human-health",bookSignature:"Venketeshwer Rao, Dennis Mans and Leticia Rao",coverURL:"https://cdn.intechopen.com/books/images_new/8077.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10223",title:"Role of Obesity in Human Health and Disease",subtitle:null,isOpenForSubmission:!1,hash:"c202a2b74cd9a2c44b1c385f103ac65d",slug:"role-of-obesity-in-human-health-and-disease",bookSignature:"Venketeshwer Rao and Leticia Rao",coverURL:"https://cdn.intechopen.com/books/images_new/10223.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10440",title:"Nuts and Nut Products in Human Health and Nutrition",subtitle:null,isOpenForSubmission:!1,hash:"4a103c51832749a8c5e73020dcc46194",slug:"nuts-and-nut-products-in-human-health-and-nutrition",bookSignature:"Venketeshwer Rao, Leticia Rao, Md Ahiduzzaman and A. K. M. Aminul Islam",coverURL:"https://cdn.intechopen.com/books/images_new/10440.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6418",title:"Hyperspectral Imaging in Agriculture, Food and Environment",subtitle:null,isOpenForSubmission:!1,hash:"9005c36534a5dc065577a011aea13d4d",slug:"hyperspectral-imaging-in-agriculture-food-and-environment",bookSignature:"Alejandro Isabel Luna Maldonado, Humberto Rodríguez Fuentes and Juan Antonio Vidales Contreras",coverURL:"https://cdn.intechopen.com/books/images_new/6418.jpg",editedByType:"Edited by",editors:[{id:"105774",title:"Prof.",name:"Alejandro Isabel",surname:"Luna Maldonado",slug:"alejandro-isabel-luna-maldonado",fullName:"Alejandro Isabel Luna Maldonado"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10359",title:"Landraces",subtitle:"Traditional Variety and Natural Breed",isOpenForSubmission:!1,hash:"0600836fb2c422f7b624363d1e854f68",slug:"landraces-traditional-variety-and-natural-breed",bookSignature:"Amr Elkelish",coverURL:"https://cdn.intechopen.com/books/images_new/10359.jpg",editedByType:"Edited by",editors:[{id:"231337",title:"Dr.",name:"Amr",surname:"Elkelish",slug:"amr-elkelish",fullName:"Amr Elkelish"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"38104",title:"The Compost of Olive Mill Pomace: From a Waste to a Resource - Environmental Benefits of Its Application in Olive Oil Groves",doi:"10.5772/48244",slug:"the-compost-of-olive-mill-pomace-from-a-waste-to-a-resource-environmental-benefits-of-its-applicatio",body:'
1. Introduction
Olive oil farming is a significant feature of land use in Mediterranean regions, covering over five million hectares in the EU Member States. The main areas of olive oil production are in Spain (2.4 million ha), followed by Italy (1.4 million ha), Greece (1 million ha) and Portugal (0.5 million ha) [1]. Whilst olive plantations are found over most of the Mediterranean region, around 65% of the Spanish olive oil area is located in Andalusia (southern Spain), representing 30% of the total EU olive oil production and about 35% of the utilized agricultural area. Therefore, olive oil farming in Andalusia is of great social, economic and environmental significance and any change in the olive oil industry in terms of management practices and post-processing options could be of wide importance, at least at the regional scale.
The olive oil industry generates large quantities of by-products. Almost all of the olive mills in Spain use the two–phase centrifugation system for oil extraction to reduce wastewater generation and lower the contaminant load, compared with the three–phase centrifugation system [2] which is currently used by other Mediterranean countries. The main by–product of the two–phase extraction system is olive mill pomace (OMP, hereafter), which in Mediterranean areas is produced during a short period over the winter, from November to February [3], the amount generated varying between 7 and 30 million m3 per year [4-6]. Typically, OMP is a semi–solid to semi–liquid by-product resulting from the mix of “alpechin”, the main by–products resulting from the older three–phase extraction procedure, and “orujo”. This by-product is made mainly with water, seed and pulp and is a potentially harmful by–product for the environment, because of the phytotoxic and antimicrobial properties, low pH, relatively high salinity and organic load, and the phenolic and lipid constituents [7-11]. Direct application to rivers or soil is not allowed under most of the national regulations of the producer countries. The main physico–chemical characterization of OMP can be found in other reports [10,12,13]. According to these studies, OMP is acidic, with a very high content of organic matter and carbon, rich in potassium (K), poor in phosphorus (P), with intermediate levels of nitrogen (N) and may also contain phenolic and lipid compounds.
Some economic (due to costs associated with disposal) and environmental problems arise from the disposal of OMP. The various options for the fate of the large amounts of OMP which are produced annually in Andalusia can be very diverse: a general description of these can be found in [14]. Briefly, one alternative for the disposal of this large amount of OMP could be in evaporative ponds, but large areas would be required for this option which might also pose several potential environmental problems such as bad odour, leaching and insect proliferation. Another major preferred option would include the generation of renewable energy taking advantage of the relatively high calorific value of OMP. Other important uses include the transformation of OMP into an organic fertiliser and soil conditioner through composting. The process of composting OMP consists of mixing it with a blend of natural organic residues (e.g. olive leaves and twigs collected after cleaning the olive fruit in the mill, and/or straw, or manures), which is then allowed to decompose in aerated piles for 7 to 9 months. This means of re-utilization can help to improve soil fertility in olive oil farms which are characterized by low organic matter, reduce the cost of inorganic fertilisers or, for a commercial enterprise, can provide an additional source of revenue for the olive oil mill economy. The main reasons for composting are that OMP has a semi–solid consistency which makes it difficult to manage, and to eliminate any phytotoxical effects by composting for at least 18 weeks [15]. Composting OMP enables it to be sanitized; the mass and volume of the product are reduced and stabilized prior to land spreading. As already mentioned, before composting, OMP is mixed with bulking agents such as olive tree leaves, which are gathered along with the olive fruit, twigs and small branches, straw [16], cotton waste [17] and manure to increase the nutrient content, or any other materials of animal or plant origin which are available locally.
In Andalusia, composted olive mill pomace (COMP, hereafter) production has increased exponentially during the last seven years from 1000 tonnes in 2003 to 70000 in 2011 [18] and there are about 14 olive mills which are producing COMP in this region. Despite this rapid increase, there are no published studies on the main agrochemical properties and the effects of OMP application to soil. Indeed, there are few studies on the main physico-chemical changes in OMP during composting [19-21], or on the chemical characterisation of the final OMP composted product [22]. Moreover, these studies have been undertaken using only a limited number of OMP composts, which were produced in only low experimental quantities and at a small experimental scale. The main aims of this chapter are to review the information from other studies and our own on the agrochemical characterization of COMP currently produced in Andalusia and on the short- and long-term effects of its application on the soil physico-chemical and biological properties.
2. Agrochemical characterization of composted olive mill pomace
The relatively high diversity of the bulking agents used (such as olive mill pomace, olive leafy material (OLM), manure or straw) as well as the variable proportion in which they are mixed is responsible for the highly heterogeneous nature and variability of the quality of the COMP.
2.1. Composition of commercially produced composted olive mill pomace
As far as we know, there are no studies on the characterization of currently commercially produced COMP. In one of our own study, seven ready to apply OMP composts were collected from different olive mills located in several provinces of Andalusia. COMP samples differed in composition and in the proportions of primary materials such as OMP, OLM, manure and straw, as shown in Table 1 and Picture 1.
Composted olive mill pomace
OMP
OLM
Manure
Straw
COMP1
80%
7%
Sheep M 13%
COMP2
75%
12%
Poultry M 13%
COMP3
60%
Sheep M 40%
COMP4
70%
8%
Sheep M 12%
10%
COMP5
85%
5%
10%
COMP6
80%
20%
COMP7
80%
13%
Poultry M 7%
Table 1.
Composition of different composted olive mill pomaces described in this chapter. OMP and OLM refer to olive mill pomace and olive leafy materials, respectively.
Picture 1
Visual appearance of the composted olive mill pomace used in this study.
COMP pH ranged 7.45 to 8.34 and were adequate for most agricultural purposes. Those COMPs made of manure tended to have a higher pH. Mean COMP pH was 8.03, a value similar to those reported by [20,23] for other experimentally–produced composts made of OMP, and is within the pH range considered as optimal for the activity of microorganisms and plant growth [24,25]. In all cases, electric conductivity was lower than the 10 dS m–1, threshold established as indicator of possible phytotoxic/phyto–inhibitory effects on plants or in soil [26]. COMP has a high content of organic matter (60.5%, on average) and carbon (30.7%, on average) (Table 2). These values are higher than those reported for cow, sheep and poultry manures and similar to those found for horse, pig and rabbit [27]. The highest values were found in those composts which included OLM and straw with little or no manure (COMP4 through to COMP7) and may be due to incomplete organic matter degradation of the larger particle sizes and the higher lignin content of OLM. A low organic matter degradation rate during composting has been reported [20], mainly because the high lignin content of the OMP and the high moisture of the initial mixture which limits sufficient aeration. For these COMPs, application to soil could be a good strategy to increase the organic matter content of soils of olive oil farms which in the Mediterranean basin are usually depleted in organic matter and are exposed to progressive degradation processes. Furthermore, the content of labile carbon in the COMPs are relatively low, indicating that respired carbon derived from compost after application to soil would be expected to be low. Therefore, COMP application to soil could increase C storage due to the high total carbon content and expected low rate of C mineralisation (see below).
Total nitrogen (TN) averaged 1.5%, and was higher for those COMP which included relatively high amounts of manure during composting (Table 2). This values is within the range of that found for compost made from plant residues [28,29] and similar to that reported for compost produced experimentally with OMP plus rabbit or sheep manure, and rice straw or almond shells [22].
The C:N ratio ranged from 27.2 to 35.8 for COMP4, COMP5 and COMP6, which did not include, or contained only limited amounts of manure, while the ratio was much lower (at 10.5 – 18.7) for COMP1, COMP2, COMP3 and COMP7, which included sheep or poultry manures (Table 2).
The total K (TK) in the composts averaged 1.7% and was highest for COMP2, which included a high proportion of poultry manure and lowest for COMP4 and COMP5, both of which included straw (Table 2). These values were within the range of values reported by other authors [20,23] for experimentally–produced compost and also similar to those of OMP [13]. This indicates that K was not lost through leaching during the composting process. The total P of the composts averaged 0.41% and was highest for those amended with manure (COMP1, COMP2 and COMP3) and lowest for those which included only OLM or straw (Table 2). TP values were lower than those of municipal solid wastes and sewage sludge, although similar to other vegetable wastes and manures [30].
Those COMPs with a high percentage of manure had lower lignin contents, but lignin content tended to increase in those COMPs with a higher proportion of OLM and straw. Polyphenol contents of the COMPs were less than 2%, even though OMP is usually characterized by high levels of polyphenols (Table 2). Polyphenols from olive oil mill waste water have been found to be toxic for some soil microorganisms [31], and this is one of the main reasons why direct application to soil cannot be recommended. The low polyphenol contents in the composts agree with values found by other researchers [32], who showed that the polyphenol content decreases during composting. In all cases, the polyphenol contents were lower than 4%: the limit which has been established where there is a shift between net N mineralization and immobilization during decomposition [33]. Those composts which are currently produced in Andalusia and which included manure showed typical lignin and polyphenol contents lower that 20% and 2%, respectively and therefore are suitable as organic fertilisers. Lignin and polyphenol contents of residues have been shown to be robust indices for the prediction of N mineralisation from residue–N after incorporation in soil [34,35], with typical thresholds for immediate net N mineralisation being < 15% lignin and < 3 – 4% total extractable polyphenol contents [36-38].
COMPs phytotoxicities (Zuconni test) were typically higher than 50%, except for COMP3 and COMP5, suggesting that a relatively high percentage of the currently produced COMPs are mature enough to be applied in the field.
COMP commercially produced (min –mean- max)
Others authors1
Organic matter (LOI) (g kg-1)
272 - 605 – 879
465 - 621
Total C (g kg-1)
184 - 307 - 390
301 - 491
Total N (g kg-1)
10.7 - 15.0 - 20.0
14.0 - 27.8
C:N
10.5 - 21.9 - 35.8
14.0 - 22.7
Total P (%)
0.19 – 0.41 -1.19
0.5 - 1.5
Total K (%)
1.06 – 1.73 -2.39
20.6 - 39.5
Lignin (g kg-1)
76.0 - 218 - 313
410 - 426
Polyphenols (%)
0.94 – 1.33 - 2.1
-
Labile organic C (g kg-1)
4.6 - 16.5 - 25.0
7.3 - 10.2
Table 2.
Main physico-chemical properties of seven commercially produced composted olive mill pomaces (Table 1) and results from bibliographic review of different authors for composted olive mill pomace. Values are mean of four replicates.1Other authors [19,20,21,22,23] for experimentally produced COMPs.
2.2.. Nutrient distribution in different particle size fractions of composted olive mill pomace
The separation and application of different COMP particle sizes could provide for better optimization of COMP management, because a fairly clear relationship between particle–size distribution of an exogenous source of organic matter and the C and N dynamics in soils for sludge compost [39] (among others) has been demonstrated. Similarly, C mineralisation and turnover was seen to differ according to the particle–size fraction in a cattle slurry compost [40,41], also from a sludge–straw mixture [42] and in an aerobically digested sewage sludge composted along with screened green waste compost, stored yard trimmings and crushed wood pallets [39]. Moreover, the nitrogen availability in compost has also been shown to be related to particle size, increasing as particle size decreased in sludge compost [43]. Generally, N mineralisation is greater in the fine and water–soluble fractions than in coarser fractions, at least for manure and city refuse composts [44] and composted sewage sludge [39]. These results suggest that the size of fractions in compost contribute substantially to the total C and N dynamics of mineralisation after compost is incorporated into soil. This is of particular interest, because depending on the range in particle sizes, composts could therefore provide a means for storage of C in soil (i.e. from the larger sized compost fractions), or a source of available N (i.e. from the finer compost fractions). The diversity and variable amount of raw materials used to obtain COMP make the final products very heterogeneous and therefore, it is expected that the nutrients and the main physico-chemical properties also differ in the particle size fractions of COMP. However, no studies existed to corroborate this, therefore in a separate study we examined whether or not this expectation about COMP was correct.
To estimate the nutrient distribution in particle size fraction of COMP, seven commercially produced COMPs were studied (Table 1) by sieving successively through to obtain 3 different sized fractions: <0.212, 0.212 – 1.0 and 1.0 – 60 mm. About 52% of COMP particles were larger than 1mm for those COMPs with a high content of manure, whereas, in contrast for COMPs without manure and with straw the consisted for 80% of these larger particle sizes.. The percentage of fine particles (<0.212 mm) doubled for COMPs with manure. These COMPs showed similar percentages of particle size fractions reported for duck manure [45], suggesting that during composting, manures generate a relatively high content of finer fractions. In general, the content of different compounds rich in organic C, such as organic matter, total carbon and lignin increased with particle size, being significantly higher for fractions between 1 to 6 mm. In sewage sludge compost made with screened refuse, yard trimmings and pallets [39], and for two types of dairy slurries others found [41], as in this study, an increase in the total C content with larger particles, although these differences were less distinct.
In contrast, nutrients contents including total N, mineral N, total P or total K were significantly higher in the fine fractions (<0.212 mm). More than 40% of the total N, P and K found in the original COMPs were in the <1 mm particle fractions in COMPs which included sheep or poultry manure during composting, whereas for COMP5, 6 and 7, the contribution of <1 mm fractions was lower than 30%. This finding agrees with those for manure and city refuse composts [44], animal slurry [41,45-47] and sludge compost [39], from workers who observed that most of the total N and various forms of N available in the short-term were mostly in the finer and water–soluble fractions.
As a result of lower N, but higher C, the C:N ratio decreased as particle size increased (Figure 1). Similar relationships between C:N ratio and particle size fractions were obtained for cattle slurry [46,47] and for sludge compost [39]. Typically, the C:N ratio for particles finer than 1 mm was lower than 18.2 in all COMPs, except those which included straw (COMP4 and COMP5), suggesting higher N availability of the organic N from these particles. During decomposition, manures with C:N ratios below 15 are likely to result in positive (net) N mineralisation after application to soil [48].
Overall, the germination index was higher than 80% in the <1 mm fractions, whereas it was lower than 50% (e.g. with some degree of phytotoxicity) for fractions 1.0 – 6.0 mm, although this was not true for COMPs made without manure (COMP5 and 6 mixtures) (Figure 1). Thus, the fractionation of the compost produced in olive mills containing <1 mm phytotoxicity–free fractions is highly recommended for commercial purposes.
Figure 1.
Box–plot of C:N, potential mineralisable N (PNM), mineralisable C and germination index of particle size fractions of combinations of COMPs according to the Principal Component Analysis. Different letters stand for significant differences (P <0.05) among particle size fractions.
The main differences among seven COMP tested according their quality was shown in the Principal Component Analysis (Figure 2). First principal component (PC1), which was negatively correlated with COMP quality indicators (e.g. total and available nutrients, C:N ratio,…), categorized the COMPs according to the pool of nutrients and organic matter and C, showing the high influence of raw materials in the quality of individual COMPs. Those COMPs made with poultry manure resulted in a high quality product, followed by COMPs made with sheep manure, whereas the quality of those COMPs made with a high proportion of OLM and straw but no manure was low. In addition, there was a trend for the quality to increase in relation to the content of finer fractions.
This highlighted the large influence of the raw materials in the final composition and quality of COMP product; a high proportion of manure increased the abundance of finer particles with high nutrients contents, whereas the addition of large amounts of OLM caused an increase in the content of larger particles with a high content of C compounds.
Overall, the separation and application of different COMP particle sizes could be useful for better optimization of COMP management, considering that the smallest particles (<1 mm) have a much higher germination index value, total N, P and K and a higher potential to mineralise N, providing a more homogeneous, high quality compost. On the other hand, larger particles (>1 mm) had higher contents of organic matter and C and tended to have the lowest C mineralisation and thus, on application to the soil in olive groves as a soil conditioner, could improve the structure and increase the organic matter of the poorer soils and increase the storage of soil organic C.
Figure 2.
Scores of the whole and the particle size fractions of the COMPs in the space defined by PC1 and PC2.
3. Effects of composted olive mill pomace on nitrogen availability
Although it is expected that the application of COMP-organic N would also supply some available N for the plant, there is little information on the decomposition rate of COMP and the impact this may have on the N available for the growth and productivity of olive trees.
Previous work [49] showed a relatively low net N mineralisation in soil after application of compost obtained from olive mill wastewater taken from an evaporative pond and other agricultural by–products, suggesting that during decomposition of composted OMP, N immobilization could take place.
More detailed knowledge of the main soil N transformations and dynamics, following COMP application to soil, could be the key to regulating soil fertility through an improved capability to predict crop available N and organic matter sequestration and losses.
3.1.. Nitrogen supply after the application of composted olive mill pomace
Available nitrogen supply throughout net N mineralisation (NM) and nitrification was studied for commercially produced COMPs differing in the raw materials co-composted with OMP (Table 1) in an aerobic incubation experiment under controlled conditions over two years. The highest rates of NM for the control soil and COMP samples were found during the first week of incubation. This positive net N mineralisation was probably from the N and C contained in the labile components of the COMP, which can be used directly by microbes as an energy source. After the initial stage of mineral N release, net N immobilization during COMP decomposition was found. Probably because the microorganisms began to decomposed the more recalcitrant compounds (with a higher C:N ratio) and this placed a demand on available soil N resulting in net N immobilization, which can ultimately be re–mineralised over time. Similar rates of mineralisation were found with mature composted materials [50,51]. This result was unexpected since, according to the TN contents, C:N ratios and lignin contents of the different COMPs, net N mineralisation would be expected according to the view that the addition of organic matter generally causes N mineralisation [52-54]. Raw materials co-composted with OMP had effects on net N mineralization. During the first year of incubation, N immobilization was found in all COMPs, except for COMPs made chiefly from OMP and OLM. After two years, decomposition of COMP resulted in a positive net N mineralization (i.e. net mineral N supply) for all COMPs (Figure 3), with values as high as 95% of that added as COMP-N. These results demonstrate that the organic N contained in the COMPs is not readily available over short to medium timescales, and suggests that most of the organic N may be in relatively recalcitrant forms. Indeed, during the composting process, N is immobilised in condensed aromatic compounds which might contribute to the reduced availability of N [55]. Therefore, the application of COMP may result in short–term declines in N availability in agricultural soils: it is therefore recommended that during the first year, the application of COMP should be combined with some other N-rich source of fertilizer. On the other hand, autumn COMP application could be a useful approach to lowering soil inorganic N levels, thereby reducing potential N losses by leaching.
3.2.. Application of composted olive mill pomace to soil reduce nitrogen losses by leaching
Plant nitrogen use efficiency is usually lower than 50%, though highly dependent on crop type and environmental conditions. There are different ways by which the N is lost and no longer available for crop uptake, such as denitrification, ammonia volatilization and leaching, which might also be associated with environmental problems. N leaching can contaminate groundwater or surface waters through runoff. Indeed, although N contamination of groundwater arises from several sources, such as industrial waste, municipal landfills, mining, or septic systems, agricultural practices remain a major source [56-58]. About 15 – 55% of N applied to crops can be lost by leaching every year [59,60]. This is particularly important in olive oil groves as many olive crops are on areas vulnerable to nitrate pollution.
Figure 3.
a) Cumulative amounts of COMP–amended inorganic N (IN) for each sampling period and (b) at the end of incubation (365 d) for COMP amended soils. Bars for each sampling represent the mean of the standard deviations of the whole set of COMP–samples.
Taking into account that N contained in COMP is not readily available in the short-term, N lost by leaching is expected to be low after application of COMP to soils. Indeed, short-term (51 days) leaching losses of N after application of COMP were similar or even lower (between -5 to 10% of the added N) than the unamended control soils in an experiment carried out under laboratory conditions. These values were much lower than those found for commercial organic fertilizer (up to 30% of the added) and urea or sodium nitrate (up to 80% of the added) for the same amount of total N added (Figure 4).
Figure 4.
Percentage of N lost as nitrate by leaching of the total N added (equivalent to 100 µg N g-1) after 51 d and three precipitation events (total precipitation equivalent to 80 l m-2). Values are the mean of 4 replicates. Bar denotes standard deviation. Different letters denote significant differences between treatments (P<0.05).
Similar results were found in an experiment under outdoor conditions after one year. Nitrate leaching in soils amended with COMP was compared with soils amended with sheep manure (sheep M), commercial organic fertilizer (CPR), or inorganic fertiliser. Fertilisers were applied at two different rates (equivalent to 100 and 200 μg N g-1) combined with two modes of application (on the soil surface or mixed with soil) and simulating autumn conditions. The lowest losses were for COMP amended soils (up to 7% of that applied) and the method of application had significant effects on mineral N leaching (Figure 5). In general, those soils which received COMP on the soil surface averaged negative mineral N losses (i.e. lower or similar losses to the control soil). N application rates had no effect on COMP IN leaching, regardless of the way the COMP was applied. Overall, inorganic N leaching for those treatments which received either Sheep M or CPR did not differ significantly, although leaching after surface application of CPR was higher than sheep M. Up to 37% of the fertiliser–derived N was leached for the ‘double’ surface application of CPR. No effects of rate or methods of application on IN leaching were found for CPR. However, for sheep M, leaching was higher at the double rate and lower for the ‘surface’, compared with the ‘mixed in’ application. The highest IN leaching reached 58% of the added N for inorganic fertiliser application (Figure 5). Results from the laboratory and outdoor experiment clearly showed the recalcitrant nature of the COMP-N (i.e. a high degree of N retention) despite the relatively low C:N ratio, confirming previous results on COMP-derived negative net N mineralisation and nitrification. Thus, application of COMP on olive oil farms distributed in the nitrate vulnerable areas might be a suitable strategy to diminish nitrate contaminated groundwater. This strategy agrees with [61] who reported that composted material can considerably lower the risk of groundwater contamination. Slow–release, controlled–release and stabilized fertilisers, such as composted OMP are recommended for several agro–environmental situations to improve nutrient use efficiency by reducing nutrient losses from the soil. Results from our studies clearly demonstrated the high efficiency of composted OMP to retain N and the beneficial reduction of nitrate leaching elicited by this compost.
Figure 5.
Cumulative fertiliser–derived mineral N (nitrate + ammonium) leaching after one year under natural rainfall and temperature in outdoor conditions for soils which received: i) composted olive mill pomace (COMP), ii) sheep manure (Sheep M), iii) commercial organic fertilisers (CPR), or iv) NaNO3 (Inor) at 1 (250 µg N g-1) or 2 (500 µg N g-1) doses. M and S, stand for soil in which the fertilisers were mixed (M) with the soil or applied to the soil surface (S). Values are means of 4 replicates and bars denote standard deviations. Different letters denote significant differences (P<0.05).
3.3. N2O emission derived of application of composted olive mill pomace
Agricultural soils are a significant source of atmospheric N2O which is of concern because of the role this gas has in global warming [62]. Emissions of N2O from soil have been shown to increase after the addition of plant residues [63] and organic fertilisers [64], the biochemical composition (or quality) being an important determinant of the magnitude of N2O emissions [65].
N2O emissions in soil amended with COMP (100 µg N g–1) were determined under aerobic incubation over 51 days. Soil N2O–N fluxes were constant and relatively low (2.71 ng N2O–N g–1 d–1), and did not vary significantly between COMP-amended and the control soils, except for the COMP which was made with moderate levels of sheep manure (COMP1) (Figure 6). The cumulative N-N2O emissions after 51-days were only 0.23% of the added COMP-N. This result was not in agreement with the well documented increase in N2O emissions after plant residue addition to soils as reported in other studies [63,65]. The very low increase in N2O emissions after COMP application suggests that N losses via denitrification after the annual application of COMP to olive oil groves are expected to be very low, and thus application of COMP could provide organic N without increasing the emissions of N2O
Figure 6.
Time course of (a) N-N2O emission rate and (b) cumulative N-N2O emission in soil amended with COMP during 51 days of lab incubation under aerobic conditions. Bars denote the mean standard deviations for each treatment and sampling point.
4. COMP-carbon mineralization
As shown above, composted olive mill pomace (COMP) has a high content of total carbon, most of which of recalcitrant nature (e.g. expected low C decomposition) such as lignin or fibre. Therefore, COMP application in soil can be a good strategy to increase the organic matter content in soil, as well as the organic C. This practice could reduce CO2 emission to the atmosphere increasing C storage in soil.
4.1. Carbon mineralization
Measurements of soil CO2 emissions can provide useful insights into soil C cycling, and provide a basis for evaluating soil C dynamics and potential C sequestration in different agricultural systems [66], particularly in intensive production systems affected by the different cropping practices and residue management [67]. Soil C can only be assimilated, and recycled through the microbial biomass, or respired [68]. Soil respiration and mineralisation are generally thought to be related to the composition of the microbial biomass, which in soils, tends to vary both across substrate qualities [69] and in time [70]. Low C mineralisation measured as CO2–C fluxes after mature COMP application have been shown [71]. However, the COMP used in this study was an experimentally produced COMP. The amount of COMP-C mineralized after 8 months of incubation after COMP application in eight soils differing in soil organic carbon (SOC) is shown in Figure 7. For all cases, the COMP-C mineralized (e.g. emitted as C-CO2) was less than 10% of that added (4 g COMP-C g-1), and this was true, independently of soil texture or SOC contents. This result suggests that C compounds in COMP are complex and refractory, resulting in a high residence time in the soil. Moreover, the percentage of COMP-C mineralisation tended to be lower at higher rates of COMP application, which indicates a higher potential for COMP-C to accumulate in the soils at higher rates of application (Figure 8).
Figure 7.
Percentage of C emitted as CO2 during COMP decomposition for eight types of soil after 240 days of incubation. Bars denote standards deviations.
Figure 8.
Effects of increasing the rate of COMP-C application to two soils differing in soil organic carbon (SOC) on cumulative COMP-C derived C-CO2 emissions after 8 months of incubation. Bars denote standards deviations of three replicates.
5. Long-term effects of composted olive mill pomace application in olive groves
The majority of the olive grove soils of Andalusia are characterised by low levels of organic matter, and are exposed to progressive degradation processes. Thus, organic matter application is required to compensate for organic carbon deficiency and to improve soil fertility. As a consequence, the use of a transformed agro-industrial waste for agricultural use, such as composted olive mill pomace, might represent a realistic solution to overcome both the soil degradation of olive oil groves and a sustainable disposal of OMP, thus increasing the sustainability of olive groves. Regional authorities, have recognised the potential use of COMP in agriculture, and have promoted composting which has resulted in an exponential increase in the production of COMP during the last 5 years, with a production of about 70000 tonnes in the 2009-2010 harvest campaign [18]. However, the long-term effects of annual application of COMP on the soil fertility of olive oil groves should be evaluated to promote more olive mill pomace composting.
Soil samples were taken from four olive oil farms; Olvera (O), Reja (R), Tobazo (T) and Andújar (A), which annually received applications of COMP during 3, 4, 9 and 16 years, respectively (COMP olive oil farms, hereafter). Soil samples were also taken from comparable olive oil farms located in the vicinity (<20 m) of each of the COMP farms that never received composted olive mill pomace (NCOMP, hereafter). These NCOMP farms have similar environmental conditions, topography and soil texture to the COMP farms. Soil samples were characterized for physico-chemical and biological variables to determine the fertility and functionality of soil after COMP application.
In general, soil pH in the 4, 9 and 16 years COMP sites was 0.31, 0.23 and 1.47 units lower than the comparable NCOMP olive farming, respectively, whereas no differences were achieved in the site after 3 years of COMP application. Moreover, the soil water holding capacity (WHC) was significantly higher in the COMP treated soils, with increases of 2 – 4% with respect to NCOMP soils. The higher (WHC) in the soils under COMP farming was expected (Table 3), due to the relatively higher levels of organic matter in these soils: the effect of organic matter on the increased potential for soils to retain water was described previously for 77 soil profiles [72]. Moreover, soil water aggregate stability was also significantly higher after COMP application for all treated soils: up to 1.5 - 2.5 times greater for COMP compared with NCOMP treated soils (Table 3). The higher soil aggregate stability in the COMP soils agrees with the findings of [73], who showed that the application OMP to soils increased this soil property from 64 to 73% after 5 years. The cation exchange capacity of soils treated with COMP was also significantly higher than in the relative NCOMP soils, independently of the site (e.g. number of years since COMP was first applied) (Table 3).
Overall, COMP application significantly increased both organic matter and carbon contents, compared with the NCOMP soil, except at the site that received COMP for only three years. The soil organic matter content in soils treated for 4, 9 and 16 years with COMP (i.e. R, T and A sites), was from 2.1 to 8.5 times greater than the respective NCOMP treated soil (Table 3). Our data confirmed previous results which indicated that soil organic matter increased after amendment with OMP during the first weeks after application [74] or after several years [73,75]. Our results also showed that organic carbon was higher in the COMP treatment compared with the NCOMP treatment. The increase in organic carbon after COMP application indicates that the decomposition rates of COMP–C were relatively low, and lower than the rates of annual COMP–C application. These recalcitrant compounds might contribute to the reduced rate of C decomposition. Soil organic carbon was higher in the soils treated with COMP, being up to eight times higher in soil where COMP was applied during the last 16 years in comparison with NCOMP farming. When extrapolating to a hectare scale, these results show that soil organic C increased up to 30 tonnes per ha-1 y-1 in soil after COMP application. The low decomposition rate of COMP and high organic C content in COMP-amended soil indicates that application of COMP in olive oil groves is an appropriate strategy to sequester organic carbon into the soil and should be evaluated further.
Overall, the total N content was higher in the COMP than in the NCOMP soils although this depended on the site. At O and R sites, which received three and four years of COMP application respectively, differences with the comparable NCOMP soils were not significant. However, total N was 1.3 and 14.8 times higher in soil with 9 and 16 years of COMP application (sites T and A) than in the comparable NCOMP treated soils (Table 3). The higher TN in COMP soils was expected, since application of organic residues normally results in an increase in the soil content of N [49,73,76]. They showed a significant increase in the TN after two to three years of application of OMP or COMP, indicating that COMP–N is very resistant to mineralisation, and therefore is retained in the soil.
Generally, soil labile phosphorus (P) in the amended COMP soils was higher than the unamended soil. In the O, R and A sites, soil available P at the COMP soils was 13.9, 260.3 and 1607 % higher than the NCOMP soil, whereas no significant difference was found at T site (Table 3). At all sites, soil exchangeable potassium was significantly higher in the COMP treated soils than in the unamended soils.
Site
WHC (%)
SA (%)
CEC (meq100 g–1)
LOI (%)
TC (%)
TN (%)
Available P (µg P g–1)
O
COMP
26.3±0.81a
51.8±2.0a
22.2±1.22ª
3.95±0.95a
2.29±0.39a
0.25±0.04a
10.6±0.04ª
NCOMP
22.3±0.3b
34.0±1.6b
20.8±0.21b
3.45±0.85a
2.00±0.49a
0.27±0.03a
9.3±0.03ª
R
COMP
21.8±1.3a
57.9±1.8ª
25.3±3.83ª
8.34±3.67a
4.84±1.90a
0.29±0.03a
30.3±0.03ª
NCOMP
20.5±1.7b
37.1±0.9b
18.6±0.27b
3.96±1.09b
2.30±0.57b
0.23±0.02a
11.5±0.02b
T
COMP
23.6±0.5a
56.7±0.2ª
21.1±3.46ª
6.31±2.22a
3.66±1.15a
0.25±0.08a
6.9±0.01ª
NCOMP
20.5±0.8b
22.6±0.6b
15.4±2.06b
2.39±0.62b
1.39±0.32b
0.10±0.02b
7.6±0.02ª
A
COMP
30.2±0.5a
23.9±1.0a
23.3±6.9ª
16.1±3.49a
8.49±2.11a
0.74±0.33a
57.4±0.33ª
NCOMP
28.7±1.3a
23.7±1.5ª
10.6±1.2b
1.88±0.41b
1.09±0.21b
0.05±0.02b
3.57±0.02b
Table 3.
Water holding capacity (WHC), soil stables aggregates (SA), cation exchangeable capacity (CEC), organic matter (LOI), total C (TC), total N (TN) and available P of olive oil farming which received (COMP) or not (NCOMP) composted olive mill pomace at Olvera (O), Reja (R), Tobazo (T) and Andújar (A). Data are the mean of five replicates ± standard deviation. Different superscript letters for each site denote significant differences between COMP and NCOMP farming (one way ANOVA; P< 0.05).
Figure 9.
Soil acid phosphatase (a), β-glucosidase (b), protease (c), invertase (d), and dehydrogenase (e) activities, potential nitrification rate (f) and geometric mean of the assayed soil enzyme in olive oil farms which received (black) or not (white) COMP at Olvera (O), Reja (R), Tobazo (T) and Andújar (A). The number of years since composted olive mill pomace has been applied to COMP farming is also indicated. Different subscript letters stand for significant differences (P < 0.05) between COMP and NCOMP farming of each site.
Soil enzyme activities related to carbon, nitrogen and phosphorus cycling have been proposed as a tool to assess soil quality/health and functioning [77]. Enzymes activities related to the C, N and P cycles were all significantly higher in soils amended with COMP than in NCOMP soils (Figure 9). Others authors [78,79] have found similar results after application of manures of different origin.
When pooling all the analysed variables in a Principal Component Analysis it was found that the first principal component (PC1) was negatively correlated with soil organic matter, total N, available P, soil aggregate stability and soil enzyme activities and therefore, PC1 is strongly related to soil functioning. PC2, on the other hand, was positively correlated with clay content, WHC and cation exchange capacity. COMP-treated soils shifted upwards (higher WHC and CEC) and towards the left (higher soil functioning) with respect to their NCOMP soils in the PC1–PC2 space (Figure 10). Therefore PCA, which included all the analysed variables, clearly separated paired plots according to the COMP application, supporting the hypothesis that COMP application improves overall soil functioning.
Figure 10.
Ordination of the COMP and NCOMP farms at Olvera (O), Reja (R), Tobazo (T) and Andújar (A) in the space defined by the PC1 and PC2 axis resulting from the PCA analysis carried out with physico–chemical and biochemical soil properties. Coordinates are the means of t five replicates and bars represent the standard deviations of the mean. Arrows illustrate the differences in the position of the COMP and NCOMP farming at each site.
Finally, the vectorial distance between comparable COMP and NCOMP farms (e.g. differences in soil functioning) tended to increase with the period of COMP application, suggesting that there is potential for further increases in soil fertility and functioning after long-term application of COMP.
6. Ecological services associated with the use of composted olive mill pomace as organic fertiliser
There is a global trend towards developing agricultural production systems which are sustainable. This involves the more efficient utilisation of inputs and the reduction of waste products. Ideally, organic by-products should be transformed into useful products by processes such as nutrient recycling, replenishment of soil organic matter or generation of energy. In this context, the cost of waste disposal would be avoided and environmental pollution reduced. This fact has led y to a widespread increase in the value of by-products of the agricultural industry. This is also now the case for OMP.
Recycling of OMP through composting (relatively easy-to-use and low costing methodology) could be a sound strategy to provide some ecological services to olive oil groves (Figure 11). Firstly, composting OMP reduces most of the potential environmental pollution problems linked with the disposal of approximately 4 million of tonnes of OMP produced in Andalusia over a relatively short-time span (3 months). On the other hand, most of the nutrients (especially nitrogen, phosphorus and potassium) harvested with the yield, are contained in the OMP, and therefore after composting and application to olive oil groves helps to recycle these nutrients, reducing the need for chemical fertilisers. Our estimates show that between one to two-thirds of the Andalusian olive oil groves could be fertilised annually with the OMP produced in Andalusia after composting, with a subsequent reduction of about 25 – 60% in chemical fertilisers. In addition, the main beneficiary of the economic and environmental profits of composting OMP and application to olive oil groves is the farmer.
Figure 11.
Fate of C, N and P of the fruit harvested in the olive oil farming when olive mill pomace (main by-product of the olive oil mill industry) is composted and applied to the olive oil groves. Some of the environmental services linked to the recycling of olive mill pomace throughout composting, are also indicated.
Some of the environmental services restored after application of COMP and shown in this chapter include: i) Increased soil organic matter and carbon. Indeed our data showed that both increased significantly after regular applications of COMP and there was a trend for increased differences in SOM and SOC between soils amended or unamended with COMP according to the number of years when COMP was applied. Other variables related directly or indirectly with the increase in SOM include i) an increase in soil microbial activity related to nutrient recycling (e.g. soil enzyme activities), cation exchange capacity, soil aggregate stability and available P and K, ii) increase in soil carbon sequestration. COMP-C derived mineralization is rather low (< 10% over one year at optimal conditions) and thus, regular applications of COMP could contribute to soil C sequestration and help alleviate the soil C-CO2 emissions linked to olive oil cultivation, iii) reduction of the potential nitrate leaching and N2O emissions. Our data on seven currently produced COMPs have demonstrated that during decomposition of OMP, soil mineral N is retained (i.e. net N immobilization) reducing not only nitrate leaching, but also N2O emissions.
7. Conclusions
The recycling of nutrient and organic matter of the olive mill pomace after its composting and application to the soil of olive oil farming is a worthwhile strategy to avoid the potential environmental harm of olive mill waste disposal and could lead to increased soil fertility and functionality. The characteristics of the COMP currently produced are adequate for agricultural purposes (high organic matter and carbon, high level of potassium and from low to medium levels of N and P, and lack of phytotoxicity) and the quality was highly dependent on the proportion of manure co-composted with olive mill pomace. COMP-N is well humified and during decomposition soil mineral N can be immobilised depending on the proportion of raw materials co-composted, and therefore it is recommended to combine N rich fertiliser with COMP during the first years of COMP application. COMP-nitrate leaching (at a temporal scale of months to a year) and nitrous oxide emissions were negligible after COMP application to soils. COMP-C mineralization was very low (< 10% of that added after one year) and, therefore, COMP application to soils could enhance C sequestration in olive oil farming. Soil fertility and functioning was improved after three years of regular applications of COMP to soils of olive oil groves a there was a clear trend for a further increase over longer periods of application.
Overall, composted olive mill pomace is a worthwhile strategy to reduce the environmental problems associated with the disposal of OLM, and increases the sustainability and ecological services of olive oil cultivation.
\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/38104.pdf",chapterXML:"https://mts.intechopen.com/source/xml/38104.xml",downloadPdfUrl:"/chapter/pdf-download/38104",previewPdfUrl:"/chapter/pdf-preview/38104",totalDownloads:3737,totalViews:806,totalCrossrefCites:4,totalDimensionsCites:17,totalAltmetricsMentions:0,impactScore:5,impactScorePercentile:93,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"November 16th 2011",dateReviewed:"May 7th 2012",datePrePublished:null,datePublished:"August 1st 2012",dateFinished:"July 28th 2012",readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/38104",risUrl:"/chapter/ris/38104",book:{id:"2168",slug:"sustainable-development-authoritative-and-leading-edge-content-for-environmental-management"},signatures:"Beatriz Gómez-Muñoz, David J. Hatch, Roland Bol and Roberto García-Ruiz",authors:[{id:"69393",title:"Dr.",name:"Roberto",middleName:null,surname:"García-Ruiz",fullName:"Roberto García-Ruiz",slug:"roberto-garcia-ruiz",email:"rgarcia@ujaen.es",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Jaén",institutionURL:null,country:{name:"Spain"}}},{id:"140998",title:"Dr.",name:"Beatriz",middleName:null,surname:"Gomez-Muñoz",fullName:"Beatriz Gomez-Muñoz",slug:"beatriz-gomez-munoz",email:"bgomez@ujaen.es",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"158485",title:"Dr.",name:"David J.",middleName:null,surname:"Hatch",fullName:"David J. Hatch",slug:"david-j.-hatch",email:"david.hatch@bbsrc.ac.uk",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"158486",title:"Dr.",name:"Roland",middleName:null,surname:"Bol",fullName:"Roland Bol",slug:"roland-bol",email:"r.bol@fz-juelich.de",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Agrochemical characterization of composted olive mill pomace",level:"1"},{id:"sec_2_2",title:"2.1. Composition of commercially produced composted olive mill pomace",level:"2"},{id:"sec_3_2",title:"2.2.. Nutrient distribution in different particle size fractions of composted olive mill pomace",level:"2"},{id:"sec_5",title:"3. Effects of composted olive mill pomace on nitrogen availability",level:"1"},{id:"sec_5_2",title:"3.1.. Nitrogen supply after the application of composted olive mill pomace",level:"2"},{id:"sec_6_2",title:"3.2.. Application of composted olive mill pomace to soil reduce nitrogen losses by leaching ",level:"2"},{id:"sec_7_2",title:"3.3. N2O emission derived of application of composted olive mill pomace",level:"2"},{id:"sec_9",title:"4. COMP-carbon mineralization",level:"1"},{id:"sec_9_2",title:"4.1. Carbon mineralization",level:"2"},{id:"sec_11",title:"5. Long-term effects of composted olive mill pomace application in olive groves",level:"1"},{id:"sec_12",title:"6. Ecological services associated with the use of composted olive mill pomace as organic fertiliser",level:"1"},{id:"sec_13",title:"7. Conclusions",level:"1"}],chapterReferences:[{id:"B1",body:'BeaufoyG.PienkowskiM.2000The environmental impact of olive oil production in the European Union: practical options for improving the environmental impact. European Forum on Nature Conservation and Pastoralism. European Commission, Brussels.'},{id:"B2",body:'Dios-PalomaresR.Haros-GiménezD.Montes-TubioF.2005Estudio estructural del sector oleícola de Andalucía. Nivel de calidad y respecto medioambiental de las industrias almazaras. Comunicaciones EXPOLIVA.'},{id:"B3",body:'MoraetisD.StamatiF. E.NikolaidisN. P.KalogerakisN.2011Olive mill wastewater irrigation of maize: impacts on soil and groundwater. Agr. Water Manage. 9811251132'},{id:"B4",body:'CabreraF.LópezR.Martinez-BordiúA.Dupuy deLome. E.MurilloJ. M.1996Land treatment of olive oil mill wastewater. Int. Biodeter. Biodegr. 38215225'},{id:"B5",body:'KavvadiasV.DoulaM. K.KomnitsasK.LiakopoulouN.2010Disposal of olive oil mill wastes in evaporation ponds: effects on soil properties. J. Hazard. Mater. 182144155'},{id:"B6",body:'López-PiñeiroA.CabreraD.AlbarránÁ.PeñaD.2011Influence of two-phase olive mill waste application to soil on terbuthylazine behaviour and persistence under controlled and field conditions. J. Soil Sediment. 11771782'},{id:"B7",body:'MJParedesMoreno. E.Ramos-CormenzanaA.MartinezJ.1987Characterization of soil after pollution with waste waters from olive oil extraction plants. Chemosphere. 1615571564'},{id:"B8",body:'PérezJ.de la RubiaT.MorenoJ.MartinezJ.1992Phenolic content and antibacterial activity of olive mill wastewater. Environ. Toxicol. Chem. 11489495'},{id:"B9",body:'LinaresA.CabaJ. M.LigeroF.De la RubiaT.MartínezJ.2003Detoxification of semisolid olive-mill wastes and pine-chip mixtures using Phanerochaete flavido-alba. Chemosphere. 51887891'},{id:"B10",body:'SierraJ.MartiE.MAGarauCruanas. R.2007Effects of agronomic use of olive oil mill wastewater- field experiment. Sci. Total Environ. 3789094'},{id:"B11",body:'PiotrowskaA.MARaoScotti. R.GianfredaL.2011Changes in soil chemical and biochemical properties following amendment with crude and dephenolized olive mill waste water (OMW). Geoderma. 161817'},{id:"B12",body:'ParedesC.CegarraJ.RoigA.MASánchez-MonederoBernal. M. P.1999Characterization of olive mill wastewater (alpechin) and its sludge for agriculture purposes. Bioresource Technol. 67111115'},{id:"B13",body:'AlburquerqueJ. A.GonzálvezJ.GarcíaD.CegarraJ.2004Agrochemical characterisation of “alperujo”, a solid by-product of the two-phase centrifugation method for olive oil extraction. Bioresource Technol. 91195200'},{id:"B14",body:'RoigA.CayuelaM. L.MASánchez-Monedero2006An overview on olive mill wastes and their valorisation methods. Waste Manage. 26960969'},{id:"B15",body:'CayuelaM. L.MillnerP.SlovinJ.Roig2007Duckweed (Lemna gibba) growth inhibition bioassay for evaluating the toxicity of olive mill wastes before and during composting. Chemosphere. 6819851991'},{id:"B16",body:'MadejónE.GalliE.TomatiU.1998Composting of wastes produced by low water consuming olive mill technology. Agrochimica. 42135146\n\t\t\t'},{id:"B17",body:'CegarraJ.AmorJ. B.GonzálvezJ.BernalM. P.RoigA.2000Characteristics of a new solid olive-mill-by-product (‘‘alperujo’’) and its suitability for composting. In: Warman, P.R, Taylor, B.R. (Eds.), Proceedings of the International Composting Symposium ICS_99, 1. CBA Press Inc, 124140'},{id:"B18",body:'Álvarez laPuente. J. M.JáureguiJ.García-RuizR.2010Composting olive mill pomace: The Andalusian experience. Biocycle. 3132'},{id:"B19",body:'García-GómezA.RoigA.BernalM. P.2003Composting of the solid fraction of olive mill wastewater with olive leaves: organic matter degradation and biological activity. Bioresource Technol. 865964'},{id:"B20",body:'AlburquerqueJ. A.GonzálvezJ.GarcíaD.CegarraJ.2006Measuring detoxification and maturity in compost made from “alperujo”, the solid by-product of extracting olive oil by the two-phase centrifugation system. Chemosphere. 64470477'},{id:"B21",body:'CanetR.PomaresF.CabotB.ChavesC.FerrerE.RibóM.AlbiachM. R.2008Composting olive mill pomace and other residues from rural southeastern Spain. Waste Manage. 281225852592'},{id:"B22",body:'AlburquerqueJ. A.GonzálvezJ.GarcíaD.CegarraJ.2007Effects of a compost made from the solid by-product (“alperujo”) of the two-phase centrifugation system for live oil extraction and cotton gin waste on growth and nutrient content of ryegrass (Lolium perenne L.). Bioresource Technol. 98940945'},{id:"B23",body:'HachichaS.SellamiF.MedhioubK.HachichaR.AmmarE.2008Quality assessment of composts prepared with olive mill wastewater and agricultural wastes. Waste Manage. 28122593603'},{id:"B24",body:'MustinM.1987Le Compost: Gestion de la Matie`re Organique. Dubusc, F. (Ed.), Paris, 117263'},{id:"B25",body:'Das KC2007Co-composting of alkaline tissue digester effluent with yard trimmings. Waste Manage. 2817851790'},{id:"B26",body:'Iannotti DA, Grebus ME, Toth BL, Madden LV, Hoitik HAJ1994Oxygen respirometric method to assess stability and maturity of composted municipal solid waste. J. Environ. Qual. 2311771183'},{id:"B27",body:'MoralR.Moreno-CasellesJ.MDPérez-Murcia-EspinosaPérez.RufeteA.ParedesB.C.2005Characterisation of the organic matter pool in manures. Bioresource Technol. 962153158'},{id:"B28",body:'MASánchez-MonederoRoig. A.ParedesC.BernalM. P.2001Nitrogen transformation during organic waste composting by the Rutgers system and its effects on pH, EC and maturity of the composting mixtures. Bioresource Technol. 78301308'},{id:"B29",body:'GoyalS.DhullS. K.KapoorK. K.2005Chemical and biological changes during composting of different organic wastes and assessment of compost maturity. Bioresource Technol. 961415841591'},{id:"B30",body:'PascualJ. A.AyusoM.GarcíaC.HernándezT.1997Characterization of urban wastes according to fertility and phytotoxicity parameters. Waste Manage. Res. 15103112'},{id:"B31",body:'CapassoR.AAEvidenteSchivo. L.OrruG.MarcialisM. A.CristinzioG.1995Antibacterial polyphenols from olive oil mill waste waters. J. Appl. Bacteriol. 79393398'},{id:"B32",body:'AitBaddi. G.AlburquerqueJ. A.GonzalvezJ.CegarraJ.HafidiM.2004Chemical and spectroscopic analyses of organic matter transformations during composting of olive mill wastes. Int. Biodeter. Biodegr. 5413944'},{id:"B33",body:'CAPalmGachengo. C. N.DelveR. J.CadischG.GillerK. E.2001Organic inputs for soil fertility management in tropical agro ecosystems: application of an organic resource database. Agr. Ecosyst. Environ. 832742'},{id:"B34",body:'FoxR. H.MyersR. J. K.VallisI.1990The nitrogen mineralization rate of legume residues in soil as influenced by their polyphenol, lignin and nitrogen contents. Plant Soil. 129251259'},{id:"B35",body:'Palm CA, Sánchez PA1991Nitrogen release from the leaves of some tropical legumes as affected by their lignin and polyphenolic contents. Soil Biol. Biochem. 238388'},{id:"B36",body:'Melillo JM, Aber JD, Muratore JF1982Nitrogen and lignin control of hardwood leaf litter decomposition dynamics. Ecology, 63621626'},{id:"B37",body:'ConstantinidesM.FownesJ. H.1994Nitrogen mineralization from leaves and litter of tropical plants-relationship to nitrogen, lignin and soluble polyphenol concentrations. Soil Biol. Biochem. 264955'},{id:"B38",body:'Palm CA, Rowland AP1997A minimum data set for characterization of plant quality for decomposition. In: G. Cadisch and K.E. Giller, Editors, Driven by Nature: Plant Litter Quality and Decomposition, CAB International, Wallingford. 379392'},{id:"B39",body:'DoubletJ.FrancouC.PétraudJ. P.DignacM. F.PoitrenaudM.HouotS.2010Distribution of C and N mineralization of a sludge compost within particle-size fractions. Bioresource Technol. 101412541262'},{id:"B40",body:'GriloJ.BolR.DixonL.ChadwickD.FangueiroD.2011Long term release of carbon from grassland soil amended with different slurry particle size fractions: a laboratory incubation study. Rapid Commun. Mass Sp. 2515141520'},{id:"B41",body:'FangueiroD.ChadwickD.DixonL.BolR.2007Quantification of priming and CO2 respiration sources following the application of different slurry particle size fractions to a grassland soil. Soil Biol. Biochem. 3926082620'},{id:"B42",body:'RobinP.AblainF.YulipriyantoH.PourcherA. M.MorvanT.CluzeauD.MorandP.2008Evolution of non-dissolved particulate organic matter during composting of sludge with straw. Bioresource Technol. 9976367643'},{id:"B43",body:'Tester CF, Sikora LJ, Taylor JM, Parr JF1979Decomposition of sewage sludge compost in soil: III. Carbon, nitrogen, and phosphorus transformations in different sized fractions, J. Environ. Qual. 87982'},{id:"B44",body:'AoyamaM.1985Properties of fine and water-soluble fractions of several composts. Micromorphology, elemental composition and nitrogen mineralization of fractions. Soil Sci. Plant Nutr. 31189198'},{id:"B45",body:'FangueiroD.GusmãoM.GriloJ.PorfírioG.VasconcelosE.CabralF.2010Proportion, composition and potential N mineralisation of particle size fractions obtained by mechanical separation of animal slurry. Biosyst. Eng. 106333337'},{id:"B46",body:'FangueiroD.BolR.ChadwickD.2008aAssessment of the potential N mineralization of six particle size fractions of two different cattle slurries. J. Plant Nutr. Soil Sc. 171313315'},{id:"B47",body:'FangueiroD.PereiraJ.ChadwickD.CoutinhoJ.MoreiraN.TrindadeH.2008bLaboratory assessment of the effect of cattle slurry pre-treatment on organic N degradation after soil application and N2O and N2 emissions. Nutr. Cycl. Agroecosys. 80107120'},{id:"B48",body:'Beauchamp EG, Paul JW1989A simple model to predict manure N availability to crops in the field. In: J.A. Hansen and K. Henriksen, Editors, Nitrogen in Organic Wastes Applied to Soils, Academic Press, London.'},{id:"B49",body:'CabreraF.Martín-OlmedoP.LópezR.MurilloJ. A.2005Nitrogen mineralization in soils amended with composted olive mill sludge. Nutr. Cycl. Agroecosys. 71249258'},{id:"B50",body:'Parker CF, Sommer LE1983Mineralization of nitrogen in sewage sludges. J. Environ. Qual. 12150156'},{id:"B51",body:'HérbertM.KaramA.ParentL. E.1991Mineralization of nitrogen and carbon in soils amended with composted manure. Biology, Agriculture and Horticulture, 7349361'},{id:"B52",body:'Chae YM, Tabatabai MA1986Mineralization in an aridisol mixed with various organic materials. J. Environ. Qual. 15193198'},{id:"B53",body:'BernalM. P.KirchmannH.1992Carbon and nitrogen mineralization and ammonia volatilization: from fresh, aerobically and anaerobically treated pig manure during incubation with soil. Biol. Fert. Soils, 13135140'},{id:"B54",body:'HadasA.PortnoyR.1994Nitrogen and carbon mineralization rates of composted manures incubated in soil. J. Environ. Qual. 2311841189'},{id:"B55",body:'SenesiN.PlazaC.BrunettiG.PoloA.2007A comparative survey of recent results on humic-like fractions in organic amendments and effects on native soil humic substances. Soil Biol. Biochem. 3912441252'},{id:"B56",body:'Ferguson RB, Shapiro CA, Hergert GW, Kranz WL, Klocke NL, Krull DH1991Nitrogen and irrigation management practices to minimize nitrate leaching from irrigated corn. J. Prod. Agric. 4186192'},{id:"B57",body:'Hallberg GR1985Agricultural chemicals and groundwater quality in Iowa: Status Report, Cooperative Extension Service, CE-2158q, Iowa State Univ, Ames, IA, 11\n\t\t\t'},{id:"B58",body:'StanleyE. H.ShortR. A.HarrisonJ. W.HallR.WiedenfeldR. C.1990Variation in a nutrient limitation of lotic and lentic algal communities in a Texas (USA) river. Hydrobiologia. 2066171'},{id:"B59",body:'Hallberg GR1989Nitrate in ground water in the United States. In R.F. Follett (ed.) Nitrogen management and ground water protection. Elsevier, New York, 3574'},{id:"B60",body:'Yadav SN1997Formulation and estimation of nitrate-nitrogen leaching from corn cultivation. J. Environ. Qual. 26808814'},{id:"B61",body:'InsamH.MerschakP.1997Nitrogen leaching from forest soil cores after amending organic recycling products and fertilizers. Waste Management Research, 15277292'},{id:"B62",body:'IPCC2007Changes in Atmospheric Constituents and in Radiative Forcing, Cambridge University Press, UK and New York USA.'},{id:"B63",body:'García-RuizR.BaggsE.2007N-N2O emissions from decomposition of plant residues in olive oil orchard. En: Towards a better efficiency in N use, 250253'},{id:"B64",body:'BaggsE. M.StevensonM.PihlatieM.RegarA.CookH.CadischG.2003Nitrous oxide emissions following application of residues and fertiliser under zero and conventional tillage. Plant Soil. 254: 361.'},{id:"B65",body:'Baggs EM, Rees RM, Smith KA, Vinten AJA2000Nitrous oxide emission from soils after incorporating crop residues. Soil Use Manage. 168287'},{id:"B66",body:'DuikerS. W.LalR.2000Carbon budget study using CO2 flux measurements from a no till system in central Ohio. Soil Till. Res. 542130'},{id:"B67",body:'AdikuS. G. K.NarhS.JonesJ. W.LaryeaK. B.DowuonaG. N.2008Short-term effects of crop rotation, residue management, and soil water on carbon mineralization in a tropical cropping system. Plant Soil, 3112938'},{id:"B68",body:'ManzoniS.ProporatoA.2009Soil carbon and nitrogen mineralization: Theory and models across scales. Soil Biol. Biochem. 4113551379'},{id:"B69",body:'ClevelandC. C.LiptzinD.2007C:N: P stoichiometry in soil: is there a “Redfield ratio” for the microbial biomass? Biogeochemistry. 85235252'},{id:"B70",body:'JensenL. S.MuellerT.MagidJ.NielsenN. E.1997Temporal variation of C and N mineralization, microbial biomass and extractable organic pools in soil after oilseed rape straw incorporation in the field. Soil Biol. Biochem. 2910431055'},{id:"B71",body:'BernalM. P.MASánchez-MonederoParedes. C.RoigA.1998Carbon mineralization from organic wastes at different composting stages during their incubation with soil. Agr. Ecosyst. Environ. 69175189'},{id:"B72",body:'Hollis JM, Jones RJA, Palmer RC1977The effect of organic matter and particle size on the water retention properties of some soils in the West Midlands of England. Geoderma. 17225238'},{id:"B73",body:'López-PiñeiroA.AlbarránA.NunesJ. M.BarretoC.2008Short and medium-term effects of two-phase olive mill waste application on olive grove production and soil properties under semiarid Mediterranean conditions. Bioresource Technol. 9979827987'},{id:"B74",body:'PiotrowskaA.IamarinoG.MARaoGianfred. L.2006Short-term effects of olive mill waste water (OMW) on chemical and biochemical properties of a semiarid Mediterranean soil. Soil Biol. Biochem. 38600610'},{id:"B75",body:'MontemurroF.ConvertiniG.FerriD.2004Mill wastewater and olive pomace compost as amendments for rye-grass. Agronomie. 24481486'},{id:"B76",body:'BenítezC.TejadaM.GonzálezJ. L.2003Kinetics of mineralization of nitrogen in a pig slurry compost applied to soils. Compost Sci. Util. 117280'},{id:"B77",body:'Dick RP1994Influence of long-term tillage and crop rotation combinations on soil enzyme activities. Soil Sci. Soc. Am. J. 56783788'},{id:"B78",body:'MäderP.FliessbacthA.DuboisD.GunstL.FriedP.NiggliU.2002Soil fertility and biodiversity in organic farming. Science. 29616941697'},{id:"B79",body:'MeleroS.PorrasJ. C.HerenciaJ. F.MadejónE.2006Chemical and biochemical properties in a silty loam soil under conventional and organic management. Soil Till. Res. 90162170'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Beatriz Gómez-Muñoz",address:null,affiliation:'
Ecology Section, University of Jaén, Campus Las Lagunillas s/n, Jaén,, Spain
'},{corresp:null,contributorFullName:"David J. Hatch",address:null,affiliation:'
Sustainable Soils and Grassland Systems Department, Rothamsted Research, North Wyke, Okehampton, Devon,, UK
Ecology Section, University of Jaén, Campus Las Lagunillas s/n, Jaén,, Spain
'}],corrections:null},book:{id:"2168",type:"book",title:"Sustainable Development",subtitle:"Authoritative and Leading Edge Content for Environmental Management",fullTitle:"Sustainable Development - Authoritative and Leading Edge Content for Environmental Management",slug:"sustainable-development-authoritative-and-leading-edge-content-for-environmental-management",publishedDate:"August 1st 2012",bookSignature:"Sime Curkovic",coverURL:"https://cdn.intechopen.com/books/images_new/2168.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:null,printIsbn:"978-953-51-0682-1",pdfIsbn:"978-953-51-5309-2",reviewType:"peer-reviewed",numberOfWosCitations:105,isAvailableForWebshopOrdering:!0,editors:[{id:"139156",title:"Dr.",name:"Sime",middleName:null,surname:"Curkovic",slug:"sime-curkovic",fullName:"Sime Curkovic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"882"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"38113",type:"chapter",title:"Oil Exploration and Climate Change: A Case Study of Heat Radiation from Gas Flaring in the Niger Delta Area of Nigeria",slug:"oil-exploration-and-climate-change-a-case-study-of-heat-radiation-from-gas-flaring-in-the-niger-delt",totalDownloads:3380,totalCrossrefCites:1,signatures:"A.S. Abdulkareem, A.S. Afolabi, J. Abdulfatai, H. Uthman and J.O. Odigure",reviewType:"peer-reviewed",authors:[{id:"64762",title:"Dr.",name:"Saka",middleName:"Ambali",surname:"Abdulkareem",fullName:"Saka Abdulkareem",slug:"saka-abdulkareem"},{id:"116233",title:"Mr.",name:"Habib",middleName:null,surname:"Uthman",fullName:"Habib Uthman",slug:"habib-uthman"},{id:"146300",title:"Prof.",name:"Ayo",middleName:"Samuel",surname:"Afolabi",fullName:"Ayo Afolabi",slug:"ayo-afolabi"},{id:"147340",title:"Dr.",name:"Abdulfatai",middleName:null,surname:"Jimoh",fullName:"Abdulfatai Jimoh",slug:"abdulfatai-jimoh"},{id:"147342",title:"Prof.",name:"Joseph",middleName:null,surname:"Odigure",fullName:"Joseph Odigure",slug:"joseph-odigure"}]},{id:"38092",type:"chapter",title:"Oil Pollution and International Marine Environmental Law",slug:"oil-pollution-and-international-marine-environmental-law",totalDownloads:6247,totalCrossrefCites:2,signatures:"Ekaterina Anyanova",reviewType:"peer-reviewed",authors:[{id:"112551",title:"Dr.",name:"Ekaterina",middleName:null,surname:"Anyanova",fullName:"Ekaterina Anyanova",slug:"ekaterina-anyanova"}]},{id:"38093",type:"chapter",title:"Use of Remote Sensing in Wildfire Management",slug:"use-of-remote-sensing-in-wildfire-management",totalDownloads:3157,totalCrossrefCites:17,signatures:"Brigitte Leblon, Laura Bourgeau-Chavez and Jesús San-Miguel-Ayanz",reviewType:"peer-reviewed",authors:[{id:"122650",title:"Prof.",name:"Brigitte",middleName:null,surname:"Leblon",fullName:"Brigitte Leblon",slug:"brigitte-leblon"}]},{id:"38103",type:"chapter",title:"GIS for Environmental Problem Solving",slug:"gis-for-environmental-problem-solving",totalDownloads:12419,totalCrossrefCites:0,signatures:"Koushen Douglas Loh and Sasathorn Tapaneeyakul",reviewType:"peer-reviewed",authors:[{id:"10635",title:"Dr.",name:"Koushen Douglas",middleName:null,surname:"Loh",fullName:"Koushen Douglas Loh",slug:"koushen-douglas-loh"},{id:"147886",title:"Ms.",name:"Sasathorn",middleName:null,surname:"Tapaneeyakul",fullName:"Sasathorn Tapaneeyakul",slug:"sasathorn-tapaneeyakul"}]},{id:"38105",type:"chapter",title:"Environmental Management in Businesses: Does It Make Money? An Accounting Perspective",slug:"environmental-management-in-businesses-does-it-make-money-an-accounting-perspective",totalDownloads:2263,totalCrossrefCites:1,signatures:"Maria J. Masanet-Llodra",reviewType:"peer-reviewed",authors:[{id:"147361",title:"Dr",name:null,middleName:null,surname:"Masanet-Llodra",fullName:"Masanet-Llodra",slug:"masanet-llodra"}]},{id:"38114",type:"chapter",title:"A Bottom Up Approach to Modeling Habitat Connectivity Dynamics Through Networks Analysis",slug:"a-bottom-up-approach-to-modeling-habitat-connectivity-dynamics-through-networks-analysis",totalDownloads:1986,totalCrossrefCites:2,signatures:"Paulo Morgado, Marina Toger, Patricia Abrantes and Jérémy Fiegel",reviewType:"peer-reviewed",authors:[{id:"149240",title:"Prof.",name:"Paulo",middleName:null,surname:"Morgado Sousa",fullName:"Paulo Morgado Sousa",slug:"paulo-morgado-sousa"},{id:"149241",title:"Prof.",name:"Patricia",middleName:null,surname:"Abrantes",fullName:"Patricia Abrantes",slug:"patricia-abrantes"},{id:"149244",title:"Ph.D. Student",name:"Marina",middleName:null,surname:"Toger",fullName:"Marina Toger",slug:"marina-toger"},{id:"149245",title:"Dr.",name:"Jéremy",middleName:null,surname:"Fiegel",fullName:"Jéremy Fiegel",slug:"jeremy-fiegel"}]},{id:"38097",type:"chapter",title:"Electronic Waste Management in Ghana - Issues and Practices",slug:"electronic-waste-management-in-ghana-issues-and-practices",totalDownloads:5486,totalCrossrefCites:14,signatures:"Martin Oteng-Ababio",reviewType:"peer-reviewed",authors:[{id:"144443",title:"Dr.",name:"Martin",middleName:null,surname:"Oteng-Ababio",fullName:"Martin Oteng-Ababio",slug:"martin-oteng-ababio"}]},{id:"38110",type:"chapter",title:"Remote Sensing Based Crop Coefficients for Water Management in Agriculture",slug:"remote-sensing-based-crop-coefficients-for-water-management-in-agriculture",totalDownloads:2673,totalCrossrefCites:9,signatures:"Jorge Rocha, António Perdigão, Raquel Melo and Cristina Henriques",reviewType:"peer-reviewed",authors:[{id:"145918",title:"Ph.D.",name:"Jorge",middleName:null,surname:"Rocha",fullName:"Jorge Rocha",slug:"jorge-rocha"},{id:"146114",title:"Dr.",name:"António",middleName:null,surname:"Perdigão",fullName:"António Perdigão",slug:"antonio-perdigao"},{id:"146117",title:"MSc.",name:"Raquel",middleName:null,surname:"Melo",fullName:"Raquel Melo",slug:"raquel-melo"},{id:"146119",title:"MSc.",name:"Cristina",middleName:null,surname:"Henriques",fullName:"Cristina Henriques",slug:"cristina-henriques"}]},{id:"38108",type:"chapter",title:"Certification and Integration of Environment with Quality and Safety - A Path to Sustained Success",slug:"certification-and-integration-of-environment-with-quality-and-safety-a-path-to-sustained-success",totalDownloads:4750,totalCrossrefCites:8,signatures:"Gilberto Santos, Manuel Rebelo, Síria Barros and Martinha Pereira",reviewType:"peer-reviewed",authors:[{id:"143706",title:"Prof.",name:"Gilberto",middleName:null,surname:"Santos",fullName:"Gilberto Santos",slug:"gilberto-santos"}]},{id:"38094",type:"chapter",title:"Uncovering the Relation Between Environmental Damage and the Rate of Rainfall Received Through a Life Cycle Assessment (LCA) Study on Potable Water Production in Malaysia",slug:"uncovering-the-relation-between-environmental-damage-and-the-rate-of-rainfall-received-through-a-lif",totalDownloads:2222,totalCrossrefCites:0,signatures:"Amir Hamzah Sharaai, Noor Zalina Mahmood and Abdul Halim Sulaiman",reviewType:"peer-reviewed",authors:[{id:"139673",title:"Dr.",name:"Amir Hamzah",middleName:null,surname:"Sharaai",fullName:"Amir Hamzah Sharaai",slug:"amir-hamzah-sharaai"},{id:"154700",title:"Dr.",name:"Noor Zalina",middleName:null,surname:"Mahmood",fullName:"Noor Zalina Mahmood",slug:"noor-zalina-mahmood"},{id:"154701",title:"Prof.",name:"Abdul Halim",middleName:null,surname:"Sulaiman",fullName:"Abdul Halim Sulaiman",slug:"abdul-halim-sulaiman"}]},{id:"38106",type:"chapter",title:"Integrated Water Management Around a Large Chemical Platform",slug:"integrated-water-management-around-a-large-chemical-platform",totalDownloads:1574,totalCrossrefCites:0,signatures:"Cristian Teodorescu, Margareta Nicolau, Adriana Cuciureanu, Marinela Petrescu, Doina Guta, Ciprian Tetiu and Rodica Baciu",reviewType:"peer-reviewed",authors:[{id:"150545",title:"Mr.",name:"Cristian",middleName:null,surname:"Teodorescu",fullName:"Cristian Teodorescu",slug:"cristian-teodorescu"}]},{id:"38107",type:"chapter",title:"Knowledge-Based Development in Small Communities - Efficient Management Based on Local Expertize",slug:"knowledge-based-development-in-small-communities-efficient-management-based-on-local-expertize",totalDownloads:1464,totalCrossrefCites:0,signatures:"Cristian Teodorescu, Lucian Constantin, Margareta Nicolau, Aurelia Ballo and Cristiana Cosma",reviewType:"peer-reviewed",authors:[{id:"150545",title:"Mr.",name:"Cristian",middleName:null,surname:"Teodorescu",fullName:"Cristian Teodorescu",slug:"cristian-teodorescu"}]},{id:"38099",type:"chapter",title:"Industrial Clusters and Environmental Management",slug:"industrial-clusters-and-environmental-management",totalDownloads:2073,totalCrossrefCites:2,signatures:"Massimo Battaglia, Tiberio Daddi and Francesco Testa",reviewType:"peer-reviewed",authors:[{id:"43319",title:"Dr.",name:"Francesco",middleName:null,surname:"Testa",fullName:"Francesco Testa",slug:"francesco-testa"},{id:"145269",title:"Dr",name:null,middleName:null,surname:"Daddi",fullName:"Daddi",slug:"daddi"},{id:"149421",title:"Dr.",name:"Massimo",middleName:null,surname:"Battaglia",fullName:"Massimo Battaglia",slug:"massimo-battaglia"}]},{id:"38112",type:"chapter",title:"Overview of Past and Ongoing Experiences Dealing with the Environmental Management at Cluster Level",slug:"overview-of-past-and-ongoing-experiences-dealing-with-the-environmental-management-at-cluster-level",totalDownloads:1831,totalCrossrefCites:0,signatures:"Francesco Testa, Tiberio Daddi, Fabio Iraldo and Marco Frey",reviewType:"peer-reviewed",authors:[{id:"9825",title:"Dr.",name:"Francesco",middleName:null,surname:"Testa",fullName:"Francesco Testa",slug:"francesco-testa"},{id:"10764",title:"Prof.",name:"Fabio",middleName:null,surname:"Iraldo",fullName:"Fabio Iraldo",slug:"fabio-iraldo"},{id:"22437",title:"Prof.",name:"Marco",middleName:null,surname:"Frey",fullName:"Marco Frey",slug:"marco-frey"},{id:"29753",title:"Dr.",name:"Tiberio",middleName:null,surname:"Daddi",fullName:"Tiberio Daddi",slug:"tiberio-daddi"}]},{id:"38096",type:"chapter",title:"Beach Erosion Management with the Application of Soft Countermeasure in Taiwan",slug:"beach-erosion-management-with-the-application-of-soft-countermeasure-in-taiwan",totalDownloads:4119,totalCrossrefCites:1,signatures:"Ray-Yeng Yang, Ying-Chih Wu and Hwung-Hweng Hwung",reviewType:"peer-reviewed",authors:[{id:"63315",title:"Prof.",name:"Hwung-Hweng",middleName:null,surname:"Hwung",fullName:"Hwung-Hweng Hwung",slug:"hwung-hweng-hwung"},{id:"144400",title:"Prof.",name:"Ray-Yeng",middleName:null,surname:"Yang",fullName:"Ray-Yeng Yang",slug:"ray-yeng-yang"},{id:"154963",title:"Ph.D. Student",name:"Ying-Chih",middleName:null,surname:"Wu",fullName:"Ying-Chih Wu",slug:"ying-chih-wu"}]},{id:"38109",type:"chapter",title:"The Economic and Financial Feasibility of a Biodigester: A Sound Alternative for Reducing the Environmental Impact of Swine Production",slug:"the-economic-and-financial-feasibility-of-a-biodigester-a-sound-alternative-for-reducing-the-environ",totalDownloads:1348,totalCrossrefCites:0,signatures:"Antonio Zanin and Fabiano Marcos Bagatini",reviewType:"peer-reviewed",authors:[{id:"149528",title:"Prof.",name:"Antonio",middleName:null,surname:"Zanin",fullName:"Antonio Zanin",slug:"antonio-zanin"},{id:"149541",title:"MSc.",name:"Fabiano",middleName:null,surname:"Bagatini",fullName:"Fabiano Bagatini",slug:"fabiano-bagatini"}]},{id:"38137",type:"chapter",title:"Overview of Environmental Management by Drill Cutting Re-Injection Through Hydraulic Fracturing in Upstream Oil and Gas Industry",slug:"overview-of-environmental-management-by-drill-cutting-re-injection-through-hydraulic-fracturing-in-u",totalDownloads:7191,totalCrossrefCites:1,signatures:"Mansoor Zoveidavianpoor, Ariffin Samsuri and Seyed Reza Shadizadeh",reviewType:"peer-reviewed",authors:[{id:"92105",title:"Dr.",name:"Mansoor",middleName:null,surname:"Zoveidavianpoor",fullName:"Mansoor Zoveidavianpoor",slug:"mansoor-zoveidavianpoor"},{id:"120519",title:"Prof.",name:"Ariffin",middleName:null,surname:"Samsuri",fullName:"Ariffin Samsuri",slug:"ariffin-samsuri"},{id:"120520",title:"Prof.",name:"Seyed Reza",middleName:null,surname:"Shadizadeh",fullName:"Seyed Reza Shadizadeh",slug:"seyed-reza-shadizadeh"}]},{id:"38095",type:"chapter",title:"A Geologic and Geomorphologic Analysis of the Zacatecas and Guadalupe Quadrangles in Order to Define Hazardous Zones Associated with the Erosion Processes",slug:"a-geologic-and-geomorphologic-analysis-of-the-zacatecas-and-guadalupe-quadrangles-in-order-to-define",totalDownloads:2104,totalCrossrefCites:0,signatures:"Felipe de Jesús Escalona-Alcázar, Bianney Escobedo-Arellano, Brenda Castillo-Félix, Perla García-Sandoval, Luz Leticia Gurrola-Menchaca, Carlos Carrillo-Castillo, Ernesto-Patricio Núñez-Peña, Jorge Bluhm-Gutiérrez and Alicia Esparza-Martínez",reviewType:"peer-reviewed",authors:[{id:"139856",title:"Dr.",name:"Felipe De Jesus",middleName:null,surname:"Escalona-Alcazar",fullName:"Felipe De Jesus Escalona-Alcazar",slug:"felipe-de-jesus-escalona-alcazar"},{id:"143611",title:"Mrs.",name:"Bianney",middleName:null,surname:"Escobedo-Arellano",fullName:"Bianney Escobedo-Arellano",slug:"bianney-escobedo-arellano"},{id:"143612",title:"Mrs.",name:"Perla",middleName:null,surname:"García-Sandoval",fullName:"Perla García-Sandoval",slug:"perla-garcia-sandoval"},{id:"143613",title:"Mrs.",name:"Luz Leticia",middleName:null,surname:"Gurrola-Menchaca",fullName:"Luz Leticia Gurrola-Menchaca",slug:"luz-leticia-gurrola-menchaca"},{id:"143614",title:"Mr.",name:"Carlos",middleName:null,surname:"Carrillo-Castillo",fullName:"Carlos Carrillo-Castillo",slug:"carlos-carrillo-castillo"},{id:"143615",title:"MSc.",name:"Ernesto Patricio",middleName:null,surname:"Núñez-Peña",fullName:"Ernesto Patricio Núñez-Peña",slug:"ernesto-patricio-nunez-pena"},{id:"143616",title:"Dr.",name:"Jorge",middleName:null,surname:"Bluhm-Gutiérrez",fullName:"Jorge Bluhm-Gutiérrez",slug:"jorge-bluhm-gutierrez"},{id:"143617",title:"MSc.",name:"Alicia",middleName:null,surname:"Esparza",fullName:"Alicia Esparza",slug:"alicia-esparza"},{id:"151450",title:"Ms.",name:"Brenda",middleName:null,surname:"Castillo-Felix",fullName:"Brenda Castillo-Felix",slug:"brenda-castillo-felix"}]},{id:"38111",type:"chapter",title:"Evaluation of Soil Quality Parameters Development in Terms of Sustainable Land Use",slug:"evaluation-of-soil-quality-parameters-development-in-terms-of-sustainable-land-use",totalDownloads:3263,totalCrossrefCites:4,signatures:"Danica Fazekašová",reviewType:"peer-reviewed",authors:[{id:"147786",title:"Associate Prof.",name:"Danica",middleName:null,surname:"Fazekašová",fullName:"Danica Fazekašová",slug:"danica-fazekasova"}]},{id:"38104",type:"chapter",title:"The Compost of Olive Mill Pomace: From a Waste to a Resource - Environmental Benefits of Its Application in Olive Oil Groves",slug:"the-compost-of-olive-mill-pomace-from-a-waste-to-a-resource-environmental-benefits-of-its-applicatio",totalDownloads:3737,totalCrossrefCites:4,signatures:"Beatriz Gómez-Muñoz, David J. Hatch, Roland Bol and Roberto García-Ruiz",reviewType:"peer-reviewed",authors:[{id:"69393",title:"Dr.",name:"Roberto",middleName:null,surname:"García-Ruiz",fullName:"Roberto García-Ruiz",slug:"roberto-garcia-ruiz"},{id:"140998",title:"Dr.",name:"Beatriz",middleName:null,surname:"Gomez-Muñoz",fullName:"Beatriz Gomez-Muñoz",slug:"beatriz-gomez-munoz"},{id:"158485",title:"Dr.",name:"David J.",middleName:null,surname:"Hatch",fullName:"David J. Hatch",slug:"david-j.-hatch"},{id:"158486",title:"Dr.",name:"Roland",middleName:null,surname:"Bol",fullName:"Roland Bol",slug:"roland-bol"}]},{id:"38101",type:"chapter",title:"Social-Ecological Resilience and Maize Farming in Chiapas, Mexico",slug:"social-ecological-resilience-and-maize-farming-in-chiapas-mexico",totalDownloads:2649,totalCrossrefCites:0,signatures:"Nils Max McCune, Francisco Guevara-Hernández, Jose Nahed-Toral, Paula Mendoza-Nazar, Jesus Ovando-Cruz, Benigno Ruiz-Sesma and Leopoldo Medina-Sanson",reviewType:"peer-reviewed",authors:[{id:"147289",title:"Prof.",name:"Francisco",middleName:null,surname:"Guevara-Hernández",fullName:"Francisco Guevara-Hernández",slug:"francisco-guevara-hernandez"},{id:"148508",title:"MSc.",name:"Nils M.",middleName:null,surname:"McCune",fullName:"Nils M. McCune",slug:"nils-m.-mccune"},{id:"153499",title:"Dr.",name:"Bruce",middleName:null,surname:"Ferguson",fullName:"Bruce Ferguson",slug:"bruce-ferguson"},{id:"153500",title:"Dr.",name:"Marijke",middleName:null,surname:"D’Haese",fullName:"Marijke D’Haese",slug:"marijke-d'haese"},{id:"155806",title:"Dr.",name:"José",middleName:null,surname:"Nahed-Toral",fullName:"José Nahed-Toral",slug:"jose-nahed-toral"},{id:"155807",title:"Dr.",name:"Paula",middleName:null,surname:"Mendoza-Nazar",fullName:"Paula Mendoza-Nazar",slug:"paula-mendoza-nazar"},{id:"155809",title:"MSc.",name:"Jesus",middleName:null,surname:"Ovando-Cruz",fullName:"Jesus Ovando-Cruz",slug:"jesus-ovando-cruz"},{id:"155810",title:"Dr.",name:"Benigno",middleName:null,surname:"Ruiz-Sesma",fullName:"Benigno Ruiz-Sesma",slug:"benigno-ruiz-sesma"},{id:"155811",title:"Dr.",name:"Leopoldo",middleName:null,surname:"Medina-Sanson",fullName:"Leopoldo Medina-Sanson",slug:"leopoldo-medina-sanson"}]},{id:"38102",type:"chapter",title:"Methodology for the Regional Landfill Site Selection",slug:"methodology-for-the-regional-landfill-site-selection",totalDownloads:4984,totalCrossrefCites:9,signatures:"Boško Josimović and Igor Marić",reviewType:"peer-reviewed",authors:[{id:"10727",title:"Dr.",name:"Bosko",middleName:null,surname:"Josimovic",fullName:"Bosko Josimovic",slug:"bosko-josimovic"},{id:"150681",title:"Dr.",name:"Igor",middleName:null,surname:"Maric",fullName:"Igor Maric",slug:"igor-maric"}]},{id:"38100",type:"chapter",title:"Land Degradation, Community Perceptions and Environmental Management Implications in the Drylands of Central Tanzania",slug:"land-degradation-community-perceptions-and-environmental-management-implications-in-the-drylands-of-",totalDownloads:6071,totalCrossrefCites:0,signatures:"Richard Y.M. Kangalawe",reviewType:"peer-reviewed",authors:[{id:"146775",title:"Prof.",name:"Richard",middleName:"Y.M.",surname:"Kangalawe",fullName:"Richard Kangalawe",slug:"richard-kangalawe"}]},{id:"38098",type:"chapter",title:"Developing a South-European Eco-Quarter Design and Assessment Tool Based on the Concept of Territorial Capital",slug:"developing-a-south-european-eco-quarter-design-and-assessment-tool-based-on-the-concept-of-territori",totalDownloads:2704,totalCrossrefCites:6,signatures:"Stella Kyvelou, Maria Sinou, Isabelle Baer and Toni Papadopoulos",reviewType:"peer-reviewed",authors:[{id:"145033",title:"Dr.",name:"Stella",middleName:null,surname:"Kyvelou-Chiotini",fullName:"Stella Kyvelou-Chiotini",slug:"stella-kyvelou-chiotini"},{id:"145042",title:"Dr.",name:"Maria",middleName:null,surname:"Sinou",fullName:"Maria Sinou",slug:"maria-sinou"},{id:"145044",title:"MSc.",name:"Antonios",middleName:null,surname:"Papadopoulos",fullName:"Antonios Papadopoulos",slug:"antonios-papadopoulos"}]}]},relatedBooks:[{type:"book",id:"4697",title:"Greenhouse Gases",subtitle:null,isOpenForSubmission:!1,hash:"a571ed811b623e82680d1ade5b4feb98",slug:"greenhouse-gases",bookSignature:"Bernardo Llamas Moya and Juan Pous",coverURL:"https://cdn.intechopen.com/books/images_new/4697.jpg",editedByType:"Edited by",editors:[{id:"169368",title:"Dr.",name:"Bernardo",surname:"Llamas",slug:"bernardo-llamas",fullName:"Bernardo Llamas"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"49894",title:"The Changing Landscape of Energy Management in Manufacturing",slug:"the-changing-landscape-of-energy-management-in-manufacturing",signatures:"Elliot Woolley, Yingying Seow, Jorge Arinez and Shahin Rahimifard",authors:[{id:"177256",title:"Dr.",name:"Elliot",middleName:null,surname:"Woolley",fullName:"Elliot Woolley",slug:"elliot-woolley"}]},{id:"49895",title:"The Choice between Economic Policies to Face Greenhouse Consequences",slug:"the-choice-between-economic-policies-to-face-greenhouse-consequences",signatures:"Donatella Porrini",authors:[{id:"177327",title:"Prof.",name:"Donatella",middleName:null,surname:"Porrini",fullName:"Donatella Porrini",slug:"donatella-porrini"}]},{id:"49858",title:"Energy for Sustainable Development: The Energy–Poverty–Climate Nexus",slug:"energy-for-sustainable-development-the-energy-poverty-climate-nexus",signatures:"Melanie L. Sattler",authors:[{id:"29285",title:"Dr.",name:"Melanie",middleName:"L",surname:"Sattler",fullName:"Melanie Sattler",slug:"melanie-sattler"}]},{id:"49654",title:"Native Forest and Climate Change — The Role of the Subtropical Forest, Potentials, and Threats",slug:"native-forest-and-climate-change-the-role-of-the-subtropical-forest-potentials-and-threats",signatures:"Silvina M. Manrique and Judith Franco",authors:[{id:"177156",title:"Dr.",name:"Silvina",middleName:null,surname:"Manrique",fullName:"Silvina Manrique",slug:"silvina-manrique"},{id:"180261",title:"Dr.",name:"Judith",middleName:null,surname:"Franco",fullName:"Judith Franco",slug:"judith-franco"}]},{id:"50153",title:"Greenhouse Gas Emissions – Carbon Capture, Storage and Utilisation",slug:"greenhouse-gas-emissions-carbon-capture-storage-and-utilisation",signatures:"Bernardo Llamas, Benito Navarrete, Fernando Vega, Elías\nRodriguez, Luis F. Mazadiego, Ángel Cámara and Pedro Otero",authors:[{id:"169368",title:"Dr.",name:"Bernardo",middleName:null,surname:"Llamas",fullName:"Bernardo Llamas",slug:"bernardo-llamas"},{id:"177312",title:"Dr.",name:"Angel",middleName:null,surname:"Camara",fullName:"Angel Camara",slug:"angel-camara"},{id:"177386",title:"Mr.",name:"Elias",middleName:null,surname:"Rodriguez",fullName:"Elias Rodriguez",slug:"elias-rodriguez"},{id:"177387",title:"Prof.",name:"Benito",middleName:null,surname:"Navarrete",fullName:"Benito Navarrete",slug:"benito-navarrete"},{id:"177388",title:"Mr.",name:"Pedro",middleName:null,surname:"Otero",fullName:"Pedro Otero",slug:"pedro-otero"}]},{id:"49936",title:"Review of Recent Developments in CO2 Capture Using Solid Materials: Metal Organic Frameworks (MOFs)",slug:"review-of-recent-developments-in-co2-capture-using-solid-materials-metal-organic-frameworks-mofs-",signatures:"Mohanned Mohamedali, Devjyoti Nath, Hussameldin Ibrahim and\nAmr Henni",authors:[{id:"147111",title:"Dr.",name:"Amr",middleName:null,surname:"Henni",fullName:"Amr Henni",slug:"amr-henni"},{id:"177302",title:"MSc.",name:"Mohanned",middleName:null,surname:"Mohamedali",fullName:"Mohanned Mohamedali",slug:"mohanned-mohamedali"},{id:"177303",title:"Dr.",name:"Hussameldin",middleName:null,surname:"Ibrahim",fullName:"Hussameldin Ibrahim",slug:"hussameldin-ibrahim"}]},{id:"49907",title:"Carbon Dioxide Geological Storage (CGS) – Current Status and Opportunities",slug:"carbon-dioxide-geological-storage-cgs-current-status-and-opportunities",signatures:"Kakouei Aliakbar, Vatani Ali, Rasaei Mohammadreza and Azin Reza",authors:[{id:"177143",title:"Ph.D. Student",name:"Aliakbar",middleName:null,surname:"Kakouei",fullName:"Aliakbar Kakouei",slug:"aliakbar-kakouei"},{id:"177149",title:"Dr.",name:"Mohammadreza",middleName:null,surname:"Rasaei",fullName:"Mohammadreza Rasaei",slug:"mohammadreza-rasaei"},{id:"177150",title:"Dr.",name:"Reza",middleName:null,surname:"Azin",fullName:"Reza Azin",slug:"reza-azin"},{id:"177151",title:"Dr.",name:"Ali",middleName:null,surname:"Vatani",fullName:"Ali Vatani",slug:"ali-vatani"}]},{id:"49649",title:"Methane Emissions from Rice Production in the United States — A Review of Controlling Factors and Summary of Research",slug:"methane-emissions-from-rice-production-in-the-united-states-a-review-of-controlling-factors-and-summ",signatures:"Alden D. Smartt, Kristofor R. Brye and Richard J. Norman",authors:[{id:"169376",title:"Dr.",name:"Kristofor",middleName:null,surname:"Brye",fullName:"Kristofor Brye",slug:"kristofor-brye"},{id:"178213",title:"Mr.",name:"Alden",middleName:null,surname:"Smartt",fullName:"Alden Smartt",slug:"alden-smartt"},{id:"178214",title:"Dr.",name:"Richard",middleName:null,surname:"Norman",fullName:"Richard Norman",slug:"richard-norman"}]},{id:"49898",title:"Greenhouse Gases Production from Some Crops Growing Under Greenhouse Conditions",slug:"greenhouse-gases-production-from-some-crops-growing-under-greenhouse-conditions",signatures:"Fernando López-Valdez , Fabián Fernández-Luqueño , Carolina\nPérez-Morales and Mariana Miranda-Arámbula",authors:[{id:"177320",title:"Ph.D.",name:"Fernando",middleName:null,surname:"López",fullName:"Fernando López",slug:"fernando-lopez"},{id:"179213",title:"Dr.",name:"Fabián",middleName:null,surname:"Fernández-Luqueño",fullName:"Fabián Fernández-Luqueño",slug:"fabian-fernandez-luqueno"},{id:"179214",title:"MSc.",name:"Carolina",middleName:null,surname:"Pérez-Morales",fullName:"Carolina Pérez-Morales",slug:"carolina-perez-morales"},{id:"179216",title:"Dr.",name:"Mariana",middleName:null,surname:"Miranda-Arámbula",fullName:"Mariana Miranda-Arámbula",slug:"mariana-miranda-arambula"}]},{id:"49871",title:"Mitigating Greenhouse Gas Emissions from Winter Production of Agricultural Greenhouses",slug:"mitigating-greenhouse-gas-emissions-from-winter-production-of-agricultural-greenhouses",signatures:"Lilong Chai, Chengwei Ma, Baoju Wang, Mingchi Liu and Zhanhui\nWu",authors:[{id:"177311",title:"Dr.",name:"Lilong",middleName:null,surname:"Chai",fullName:"Lilong Chai",slug:"lilong-chai"}]},{id:"49861",title:"Livestock as Sources of Greenhouse Gases and Its Significance to Climate Change",slug:"livestock-as-sources-of-greenhouse-gases-and-its-significance-to-climate-change",signatures:"Veerasamy Sejian, Raghavendra Bhatta, Pradeep Kumar Malik,\nBagath Madiajagan, Yaqoub Ali Saif Al-Hosni, Megan Sullivan and\nJohn B. Gaughan",authors:[{id:"89780",title:"Dr.",name:"Veerasamy",middleName:null,surname:"Sejian",fullName:"Veerasamy Sejian",slug:"veerasamy-sejian"},{id:"177145",title:"Dr.",name:"Pradeep Kumar",middleName:null,surname:"Malik",fullName:"Pradeep Kumar Malik",slug:"pradeep-kumar-malik"},{id:"177210",title:"Dr.",name:"Raghavendra",middleName:null,surname:"Bhatta",fullName:"Raghavendra Bhatta",slug:"raghavendra-bhatta"},{id:"177220",title:"Dr.",name:"M",middleName:null,surname:"Bagath",fullName:"M Bagath",slug:"m-bagath"},{id:"178273",title:"Mr.",name:"Yaqoub Ali Saif",middleName:null,surname:"Al-Hosni",fullName:"Yaqoub Ali Saif Al-Hosni",slug:"yaqoub-ali-saif-al-hosni"},{id:"178275",title:"Dr.",name:"Megan",middleName:null,surname:"Sullivan",fullName:"Megan Sullivan",slug:"megan-sullivan"},{id:"178276",title:"Dr.",name:"John B",middleName:null,surname:"Gaughan",fullName:"John B Gaughan",slug:"john-b-gaughan"}]},{id:"49879",title:"Life Cycle Assessment Method – Tool for Evaluation of Greenhouse Gases Emissions from Agriculture and Food Processing",slug:"life-cycle-assessment-method-tool-for-evaluation-of-greenhouse-gases-emissions-from-agriculture-and-",signatures:"Zuzana Jelínková, Jan Moudrý Jr, Jan Moudrý, Marek Kopecký and\nJaroslav Bernas",authors:[{id:"170254",title:"Associate Prof.",name:"Jan",middleName:null,surname:"Moudrý",fullName:"Jan Moudrý",slug:"jan-moudry"}]},{id:"49908",title:"Carbon Footprint as a Tool to Limit Greenhouse Gas Emissions",slug:"carbon-footprint-as-a-tool-to-limit-greenhouse-gas-emissions",signatures:"Francesco Fantozzi and Pietro Bartocci",authors:[{id:"177235",title:"Dr.",name:"Pietro",middleName:null,surname:"Bartocci",fullName:"Pietro Bartocci",slug:"pietro-bartocci"},{id:"177243",title:"Prof.",name:"Francesco",middleName:null,surname:"Fantozzi",fullName:"Francesco Fantozzi",slug:"francesco-fantozzi"}]}]}],publishedBooks:[{type:"book",id:"2168",title:"Sustainable Development",subtitle:"Authoritative and Leading Edge Content for Environmental Management",isOpenForSubmission:!1,hash:"2390760489adb85a77ad5db8df83fa05",slug:"sustainable-development-authoritative-and-leading-edge-content-for-environmental-management",bookSignature:"Sime Curkovic",coverURL:"https://cdn.intechopen.com/books/images_new/2168.jpg",editedByType:"Edited by",editors:[{id:"139156",title:"Dr.",name:"Sime",surname:"Curkovic",slug:"sime-curkovic",fullName:"Sime Curkovic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4697",title:"Greenhouse Gases",subtitle:null,isOpenForSubmission:!1,hash:"a571ed811b623e82680d1ade5b4feb98",slug:"greenhouse-gases",bookSignature:"Bernardo Llamas Moya and Juan Pous",coverURL:"https://cdn.intechopen.com/books/images_new/4697.jpg",editedByType:"Edited by",editors:[{id:"169368",title:"Dr.",name:"Bernardo",surname:"Llamas",slug:"bernardo-llamas",fullName:"Bernardo Llamas"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8156",title:"Sustainability Assessment at the 21st century",subtitle:null,isOpenForSubmission:!1,hash:"222ef024272a36394c5213ab97c07d29",slug:"sustainability-assessment-at-the-21st-century",bookSignature:"María José Bastante-Ceca, Jose Luis Fuentes-Bargues, Levente Hufnagel, Florin-Constantin Mihai and Corneliu Iatu",coverURL:"https://cdn.intechopen.com/books/images_new/8156.jpg",editedByType:"Edited by",editors:[{id:"210968",title:"Dr.",name:"María José",surname:"Bastante-Ceca",slug:"maria-jose-bastante-ceca",fullName:"María José Bastante-Ceca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9845",title:"Landscape Architecture",subtitle:"Processes and Practices Towards Sustainable Development",isOpenForSubmission:!1,hash:"e60932edd4a5d1f03606853a11f7616a",slug:"landscape-architecture-processes-and-practices-towards-sustainable-development",bookSignature:"Luís Loures and Mustafa Ergen",coverURL:"https://cdn.intechopen.com/books/images_new/9845.jpg",editedByType:"Edited by",editors:[{id:"108118",title:"Dr.",name:"Luis",surname:"Loures",slug:"luis-loures",fullName:"Luis Loures"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"2168",title:"Sustainable Development",subtitle:"Authoritative and Leading Edge Content for Environmental Management",isOpenForSubmission:!1,hash:"2390760489adb85a77ad5db8df83fa05",slug:"sustainable-development-authoritative-and-leading-edge-content-for-environmental-management",bookSignature:"Sime Curkovic",coverURL:"https://cdn.intechopen.com/books/images_new/2168.jpg",editedByType:"Edited by",editors:[{id:"139156",title:"Dr.",name:"Sime",surname:"Curkovic",slug:"sime-curkovic",fullName:"Sime Curkovic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"81240",title:"Drug Delivery Applications of Metal-Organic Frameworks (MOFs)",doi:"10.5772/intechopen.103684",slug:"drug-delivery-applications-of-metal-organic-frameworks-mofs",body:'
1. Introduction
The use of nanomaterials as carriers for the administration of drugs and therapeutic agents is gaining increased attention. These nanocarriers are facilely taken up by the cells and are able to deliver the drug to the target site and prevent its rapid clearance or degradation [1]. Although several inorganic (such as iron oxide NPs, noble metal NPs, quantum dots, etc.) and organic (such as liposomes, polymers, dendrimers) nanomaterials have been produced as nanocarriers, each of these classes of nanomaterials has its own set of merits and demerits [2, 3]. Only a few of these nanosized drug carriers have been approved by the US Food and Drug Administration (FDA); though still, they have some limitations [4].
Metal–organic frameworks (MOFs) also referred to as porous coordination polymers (PCPs) are a crystalline class of coordination polymers and were first reported by Bernard F. Hoskins and Richard Robson in 1989 [5, 6]. MOFs are being synthesized in a building block fashion, in which inorganic building units (metal ion vertices or clusters) are interconnected by organic building units (organic linker molecules) by a self-assembly process, to form highly tailorable crystalline materials having pores in the nanometer range [7]. Their unique combination of high porosity, large surface areas, lack of non-accessible bulk volume, a wide range of pore sizes (micro- or mesopores), shapes (cages, channels, etc.) and topologies, tunable and rigid frameworks, easy surface functionalization, and a limitless number of possible combinations of metals and ligands have resulted in a large number of their potential applications [8, 9].
Nanoscale Metal–organic frameworks or Metal–organic framework nanoparticles (NMOFs or MOF NPs), nanoscale counterparts of MOFs are an attractive class of hybrid nanomaterials. These NMOFs not only exhibit the unique features of porous nanomaterials, but they also have benefits over analogous bulk MOFs for a variety of biomedical applications due to their small size. They can offer many advantages over conventional nanocarriers. (i) First, they can be designed to form desired structures with different shapes, sizes and chemical properties allowing for the loading of various therapeutic agents with different functionalities; (ii) next, their large surface area, high porosity, uniform pore size and volume results in high loading efficiency and selective transport; (iii) further, as a result of their somewhat labile metal and ligand coordination bonds, they are intrinsically biodegradable, which prevents their accumulation in the body after their task is achieved; (iv) finally, their surface functionalization by post-synthetic modifications can improve their colloidal stability, thereby prolonging their blood circulation time [10, 11, 12]. Thus, the miniaturization of MOFs to NMOFs has resulted in the development of nanomaterials with great potential to be used as drug delivery systems. The structural flexibility (referred to as “breathing”) and switchability of MOFs is a unique feature not found in other porous materials [13].
This chapter will give the readers an overview of the use of MOFs and NMOFs as potential drug carriers. In the succeeding sections, the basic composition and structure of these porous frameworks and general synthetic routes adopted for their preparation shall be discussed. Commonly used drug incorporation techniques and characterization methods to verify drug association will also be presented. In the final section, a summary of some of the MOFs and NMOFs reported as carriers and for application in the delivery of therapeutic drugs, biomolecules such as proteins, nucleic acids, carbohydrates, and other active agents employed for light and magnetic field activated therapies, shall be provided.
2. Structure of MOFs
The design principles of reticular chemistry suggest that deconstruction of a MOF results in four levels of structure [14].
The primary structure reveals the chemical composition of MOF, comprising of a metal ion (generally multivalent) and a polydentate organic linker molecule (topicity i.e., points of extension varying between 2 and 12) [15].
Secondary building units or SBUs, which are mostly formed in situ, are obtained at the secondary level. These are basically polynuclear metal clusters locking the metal ion into a fixed geometry thereby giving directionality and rigidity to the final MOF structure [16].
The tertiary level involves stitching of multiple SBUs together or two metal ions by bridging linkers (having binding groups like phosphates, carboxylates, imidazolates, etc.), giving rise to an internal framework comprising of pores and channels [15].
The outer morphology (size and shape) or quaternary structure of MOF depends on the synthesis procedure dictating the growth of the internal framework [17].
Figure 1 depicts the above four levels of MOF structure concerning MOF-5.
Figure 1.
Structure of MOF-5. (a) Primary structure showing composition: metal ion (Zn2+) and linker (terephthalic acid), (b) secondary structure: SBU, Zn4O(-COO)6, (c) tertiary structure: internal framework formed showing linking of SBUs by the terephthalic acid linker, (d) quaternary structure: overall morphology.
3. Synthesis of NMOFs
Specialized synthetic routes are a prerequisite to obtaining MOFs in the nano-range, ideal for drug administration. The choice of synthesis protocol determines the final size, crystallinity, morphology, uniformity and stability of NMOF. Figure 2 shows a summary of the most often used approaches.
Figure 2.
Schematic representation of various synthetic methods used for the synthesis of NMOFs.
Nanoprecipitation is based on the premise that although the precursors (metal ion and linker) are miscible in the original solvent, the formed nanoparticles are either immiscible or can be precipitated out by adding another solvent in which it is not soluble [18].
Solvothermal synthesis, performed at higher temperatures results in highly crystalline particles and can be used in combination with surfactants to form surfactant-coated stable particles [19].
Reverse microemulsions (sometimes called nanoreactors), which are water-in-oil systems stabilized by appropriate surfactants, can be used as templates to produce monodisperse particles, and size control can be achieved by varying the wo (water: surfactant ratio) value [20].
Other, less commonly used methods include the use of microwaves, ultrasounds, etc. [21, 22]. NMOFs are generally post-synthetically modified or altered to impart them with extra stability, targeting ability, and biocompatibility [23].
4. Drug incorporation strategies
Some MOFs possess rigid and permanent pores, whereas others are flexible and can respond to external/internal stimuli such as temperature, light, pH, etc. by changing their pore size [24]. In addition, MOFs have distinct features such as breathing, linker rotation, swelling, and subnetwork displacements, which are important for drug loading and release management [25]. There are many ways to associate a drug with MOF, which may be a medicine, a gene, a protein, an enzyme, or any other agent of therapeutic importance.
The first approach is to carry out the encapsulation of the drug/therapeutic agent during the synthesis of MOF; this method is referred to as one-pot synthesis [26, 27]. This method can be used to entrap one or more drugs larger than the pore size of MOF and prevents its premature leaching.
Another approach is to directly incorporate the prodrug or drug into the framework by using it as a ligand giving higher loading efficiency [28, 29]. The only limitation of this method is that it can lead to loss of therapeutic activity of the incorporated drug.
Smaller drugs/cargos can also be post-synthetically encapsulated by introducing them into a dispersion of MOF in a suitable solvent in which they can subsequently diffuse through channels inside MOF pores [30]. This way the drug can also be physically adsorbed on the outer surface by electrostatic interactions.
Another method is to post-synthetically associate the drug through covalent bonding with functional groups of organic linkers or by the formation of coordination bonds to metal ions present at coordinatively-unsaturated sites (CUSs) [21, 31, 32, 33, 34]. These CUSs present on the MOF surface behave as Lewis acids and solvent molecules at these sites can be replaced by drugs.
Figure 3 gives a schematic illustration of some of these drug-loading techniques. Multimodal and theranostic systems can also be obtained by using one or more loading techniques to incorporate multiple drugs.
Figure 3.
(a) One-pot synthesis of ZIF-8 NMOF encapsulating zinc phthalocyanine, a photosensitizer used for PDT. Reproduced with permission from [26]. Copyright 2018 American Chemical Society. (b) Direct assembly of porphyrin-based DBC ligand in DBC-UiO NMOF for PDT application. Reproduced with permission from [29]. Copyright 2015 American Chemical Society. (c) Coordinative interaction of His-tags with CUS of MOF: (i) basic MOF molecular composition; (ii) formation of coordinate bond between CUS metal ion (Lewis acid) and imidazolate group of histidine (Lewis base); (iii) generation of multifunctional MOFs by attachment of multiple His-tags. Reproduced with permission from [33]. Copyright 2017 American Chemical Society. (d) Post-synthetic covalent attachment of amino group of DOX to aldehyde of ICA linker in ZIF-90, followed by loading of 5-Fluoro uracil into the pores of NMOF. Reproduced with permission from [34]. Copyright 2017 American Chemical Society.
5. Characterization
Loading of drugs by MOFs can be confirmed by various methods. Spectroscopic techniques such as UV–visible and fluorescence spectroscopy are useful to confirm encapsulation/loading of chromophoric and fluorescent drugs. Encapsulation of zinc phthalocyanine (ZnPc), which shows characteristic absorbance peaks at 605 and 670 nm was confirmed by the presence of these peaks in the absorbance spectrum of ZnPc@ZIF-8 but absence in the spectrum of only ZIF-8 [26]. This technique is also helpful to quantify the loaded drug. Determination of Brunauer–Emmett–Teller (BET) surface area and pore volume can also help in verifying successful encapsulation of drug. Nitrogen adsorption analysis of ZIF-90, ZIF-90-DOX, and 5-FU@ZIF-90-DOX showed BET surface areas 1045.7, 890.4, and 48.3 m2/g, respectively. A decrease in BET surface area validated drug loading [34]. Deviations in the TGA curve of drug incorporated MOF are also indicative of drug loading. TGA curve of ZIF-90 showed no significant loss in weight between 300 and 500° C, whereas ZIF-90-DOX showed much larger weight loss in the same temperature range. Zeta potential and hydrodynamic size measurement by dynamic light scattering (DLS) experiments can also confirm the nature of the association of MOF with the drug. Pure ZIF-8 nanospheres had a more positive zeta potential value of +31.4 mV, as compared to +22.9 mV for fluorescein adsorbed ZIF-8 nanospheres. This indicated surface adsorption of negatively charged fluorescein dye on the surface of positively charged nanospheres [35]. A very small change in negative zeta potential value for MIL-100 and DM NPs (DOX loaded MIL-100 NPs) confirmed encapsulation of DOX majorly inside the particle with some surface adsorption [36]. Other techniques such as FT-IR spectroscopy, PXRD, NMR, and electron microscopy techniques such as SEM and TEM are also frequently used for characterizing MOFs, with and without drugs [30, 37, 38, 39].
6. Applications in drug delivery
MOFs are unique inorganic–organic hybrid materials possessing ultrahigh surface area and porosity. They are crystalline, have flexible and rigid frameworks, and also exhibit high chemical and thermal stability. MOFs have been continuously and thoroughly explored and reviewed for numerous applications. Several applications related to MOFs have been reported such as for gas storage and separation, [40, 41, 42] catalysis, [43, 44] sensing, [45] magnetism, [46] and energy [47]. In addition, various biomedical applications have also been reported, including biological sensing, [48] molecular imaging, targeted drug delivery, [21, 49] among others [11].
A large number of side effects are associated with uncontrolled and non-specific drug delivery by direct administration of a free drug inside the body. Great efforts have been made by researchers for the development of methods for targeted, systemic, and controlled drug administration. Nanocarriers have provided a simple and effective solution to this problem. Both organic (such as dendrimers, liposomes, etc.) and inorganic (such as noble metal and metal oxide nanoparticles, quantum dots, silica nanoparticles, etc.) nanocarriers have been reported as potential drug delivery vehicles. Organic nanocarriers such as liposomes are less stable and easily captured by the reticuloendothelial system (RES) once inside the body [50]. Inorganic nanocarriers such as gold, silver, and silica nanoparticles have been reported to be cytotoxic [51]. Inorganic–organic hybrid nanocarriers, such as porous NMOFs, offer many advantages over their pure organic and inorganic counterparts and have established themselves as optimal drug delivery vehicles. In the following subsections, the applications of NMOFs for the delivery and as carriers of therapeutic drugs, biomolecules such as proteins, enzymes, carbohydrates, nucleic acids, and other active agents, shall be discussed briefly.
6.1 Therapeutic drugs
MOFs, owing to their porous structure have been frequently reported for delivery of therapeutic agents such as analgesics, antibiotics, anti-inflammatory and anti-cancer drugs, based on both in vitro and in vivo experiments. In 2006, Horcajada et al. were the first ones to report the ability of MOFs to act as efficient drug delivery agents. They prepared two mesoporous cubic MOFs, namely MIL-100 and MIL-101. They employed them to adsorb ibuprofen, a commonly used anti-inflammatory drug and found that MIL-101 with a larger cage size was able to adsorb more amount of drug (1.4 g/g of MOF) [30]. Nasrabadi et al. reported the use of UiO-66 NMOF with surface area 1196 m2/g to post-synthetically load ciprofloxacin (CIP), an antibiotic. The resulting CIP-UiO-66 NMOF showed a very high drug loading percentage of about 84%, with significant antibacterial activity against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacteria in comparison to free CIP [52]. ZIF-8 is a pH-responsive MOF, which disintegrates in an acidic environment, and thus is a promising drug carrier especially for anti-cancer applications because of acidic nature of tumor micro-environment. Sun et al. for the first time reported the use of ZIF-8 for the controlled and pH-triggered release of 5-fluorouracil (5-FU), an anticancer drug with high loading capacity (660 mg/g of MOF) [53]. Table 1 summarizes some of the NMOFs and MOFs reported for the delivery of therapeutic agents.
Examples of MOFs and NMOFs employed as carriers for therapeutic agents.
6.2 Biomolecules
MOFs have proven themselves as effective carriers for the delivery of large biomolecules such as proteins, enzymes, DNA, RNA, and carbohydrates and small biomolecules such as amino acids, peptides and nucleotides [73]. These biomolecule-MOF composites protect the biodegradation of these biomolecules inside physiological systems and offer a pathway for their safe delivery. Many diseases are a result of protein deficiencies in the body. Also, nucleic acid and carbohydrates based therapies are gaining increasing interest. Intracellular delivery of these biomolecules using MOFs will help in preserving their bioactivity and they will be able to reach their targets avoiding unwanted side effects. There are many methods to form biomolecule-MOF composites. Post-synthetic pore entrapment is the most used method, in which biomolecules smaller than the cavity size of MOF directly diffuse into the pores of the MOF. Chen et al. have demonstrated the use of mesoporous NU-1000 MOF for the entrapment of insulin with high loading (approximately 40%) to treat diabetes mellitus (type 2) [74]. Surface attachment/adsorption is another method that is relatively easy, and biomolecules of all sizes can be attached/adsorbed on the surface via non-covalent interactions such as hydrogen bonding, π-π interactions, Van-der waals interaction, etc. Ni et al. have reported Hf-DBP NMOF for the delivery of αCD47 antibody attached to its surface [75]. Biomolecules can also be covalently linked to MOFs. Wang et al. immobilized dibenzylooctyne (DBCO) appended DNA on UiO-66-N3 through click reaction between DBCO and azide (N3) group [76]. Co-precipitation or one-pot synthesis is another method for biomolecule-MOF composites. The biomolecule is encapsulated during the synthesis of MOF giving high loading and preventing leakage. Shieh et al. used this de novo approach to encapsulate catalase enzyme into the pores of ZIF-90 [77]. Biomimetic mineralization is another in situ encapsulation method in which biomolecules act as templates and nucleation sites for the growth of MOF around them, dictating their final size and morphology. Liang et al. demonstrated the use of various protein, enzyme and DNA templates for the synthesis of MOFs by biomimetic mineralization [38]. Bio-MOFs can also be synthesized by incorporating biomolecules into the framework. Biomolecules have reactive functional groups. They can act as organic linkers and react with metal ions to form bio-MOFs. An et al. synthesized bio-MOF-1 made up of zinc-adeninate clusters and biphenyl dicarboxylic acid. The adenine nucleobase consists of ring N atoms and an amino group that can coordinate with metal ions [78]. Table 2 lists some of the biomolecule-MOF composites.
Examples of biomolecule-MOF composites incorporating biomolecules of biological importance.
6.3 Other active agents
Targeted delivery of photoactive compounds such as photosensitizers (dyes, metal nanoparticles/clusters, quantum dots, etc.) incorporated with MOFs and NMOFs can be achieved, preventing their degradation and accumulation in the physiological systems. These compounds are essential for light-activated novel therapies such as photodynamic therapy (PDT) and photothermal therapy (PTT). Xu et al. incorporated a hydrophobic porphyrin-based dye, zinc phthalocyanine inside the pores of ZIF-8 for PDT [26]. Sharma et al. synthesized a bioactive MOF, MB/Cu-GA, for simultaneous PDT and drug delivery. Gallic acid (GA), an anti-cancer agent was directly incorporated into the MOF framework, and the photosensitizer, methylene blue (MB) was post-synthetically encapsulated [101]. Magnetic nanoparticles can also be encapsulated or decorated on the surface of MOF for magneto-cytolytic therapy (magnetic hyperthermia). Chen et al. prepared Fe3O4@PDA@ZIF-90 loaded with DOX nanocomposites for combined magnetic hyperthermia and chemotherapy [102]. Table 3 summarizes some of the examples of MOFs employed for the delivery of photosensitizers and magnetic nanoparticles.
Examples of NMOFs and MOFs as carriers of active agents for novel therapies.
7. Conclusion
This chapter gives a general perspective regarding the use of metal–organic frameworks as drug carriers, in terms of their composition, structure, synthesis, procedures to incorporate drugs and characterization techniques. MOFs are highly porous frameworks with large surface area, made up of repeating units, and generally synthesized by solvothermal and non-solvothermal methods. Therapeutic agents and drugs can be encapsulated, post synthetically attached on the surface, or directly incorporated into the framework. Apart from these compounds, functional biomolecules can also be incorporated with MOFs for the possible treatment of various diseases and therapies. Due to their distinct physicochemical properties, MOFs and NMOFs are gaining prominence for various applications. MOFs have already established themselves as efficient systems for gas storage and separation. Their use as potential drug carriers is relatively new. The available work done by researchers around the world for utilizing these porous frameworks as carriers for drugs will help in synthesizing and designing MOF-drug composites in the future, that can successfully be used for real-world applications.
Acknowledgments
Ashi Mittal acknowledges fellowship support from the University Grants Commission (UGC), Government of India.
Conflict of interest
The authors declare no conflict of interest.
Nomenclature
\n',keywords:"metal–organic frameworks, synthesis, drug encapsulation, characterization, drug delivery, biomolecules, photosensitizers",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/81240.pdf",chapterXML:"https://mts.intechopen.com/source/xml/81240.xml",downloadPdfUrl:"/chapter/pdf-download/81240",previewPdfUrl:"/chapter/pdf-preview/81240",totalDownloads:42,totalViews:0,totalCrossrefCites:0,dateSubmitted:"February 8th 2022",dateReviewed:"February 14th 2022",datePrePublished:"April 25th 2022",datePublished:null,dateFinished:"April 12th 2022",readingETA:"0",abstract:"There has been substantial progress in the field of metal–organic frameworks (MOFs) and their nanoscale counterparts (NMOFs), in recent years. Their exceptional physicochemical properties are being constantly and actively exploited for various applications such as energy harvesting, gas storage, gas separation, catalysis, etc. Due to their porous framework, large surface area, tunability and easy surface functionalization, MOFs and NMOFs have also emerged as useful tools for biomedical applications, specifically for drug delivery. As drug carriers, they offer high drug loading capacity and controlled release at the target site. This chapter aims to give a panorama of the use of these MOFs as drug delivery agents. A brief overview of the structure and composition of MOFs, along with various methods and techniques to synthesize NMOFs suitable for drug delivery applications are mentioned. In addition, the most commonly employed strategies to associate drugs with these NMOFs are highlighted and methods to characterize them are also briefly discussed. The last section summarizes the applications of MOFs and NMOFs as carriers of therapeutic drugs, biomolecules, and other active agents.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/81240",risUrl:"/chapter/ris/81240",signatures:"Ashi Mittal, Indrajit Roy and Sona Gandhi",book:{id:"11319",type:"book",title:"Drug Carriers",subtitle:null,fullTitle:"Drug Carriers",slug:null,publishedDate:null,bookSignature:"Dr. Luis Jesús Villarreal-Gómez",coverURL:"https://cdn.intechopen.com/books/images_new/11319.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-832-5",printIsbn:"978-1-80355-831-8",pdfIsbn:"978-1-80355-833-2",isAvailableForWebshopOrdering:!0,editors:[{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Structure of MOFs",level:"1"},{id:"sec_3",title:"3. Synthesis of NMOFs",level:"1"},{id:"sec_4",title:"4. Drug incorporation strategies",level:"1"},{id:"sec_5",title:"5. Characterization",level:"1"},{id:"sec_6",title:"6. Applications in drug delivery",level:"1"},{id:"sec_6_2",title:"6.1 Therapeutic drugs",level:"2"},{id:"sec_7_2",title:"6.2 Biomolecules",level:"2"},{id:"sec_8_2",title:"6.3 Other active agents",level:"2"},{id:"sec_10",title:"7. Conclusion",level:"1"},{id:"sec_11",title:"Acknowledgments",level:"1"},{id:"sec_14",title:"Conflict of interest",level:"1"},{id:"sec_13",title:"Nomenclature",level:"1"}],chapterReferences:[{id:"B1",body:'Wilczewska AZ, Niemirowicz K, Markiewicz KH, Car H. Nanoparticles as drug delivery systems. Pharmacological Reports. 2012;64:1020-1037. DOI: 10.1016/s1734-1140(12)70901-5'},{id:"B2",body:'Wu MX, Yang YW. Metal-organic framework (mof)-based drug/cargo delivery and cancer therapy. Advanced Materials. 2017;29:e1606134. DOI: 10.1002/adma.201606134'},{id:"B3",body:'Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics: An emerging treatment modality for cancer. Nature Reviews. Drug Discovery. 2008;7:771-782. DOI: 10.1038/nrd2614'},{id:"B4",body:'Anselmo AC, Mitragotri S. Nanoparticles in the clinic: An update. Bioeng Translational Medicine. 2019;4:e10143. DOI: 10.1002/btm2.10143'},{id:"B5",body:'Luo Z, Fan S, Gu C, Liu W, Chen J, Li B, et al. Metal-organic framework (MOF)-based nanomaterials for biomedical applications. Current Medicinal Chemistry. 2019;26:3341-3369. DOI: 10.2174/0929867325666180214123500'},{id:"B6",body:'Hoskins BF, Robson R. Infinite polymeric frameworks consisting of three dimensionally linked rod-like segments. Journal of the American Chemical Society. 1989;111:5962-5964. DOI: 10.1021/ja00197a079'},{id:"B7",body:'Peller M, Böll K, Zimpel A, Wuttke S. Metal-organic framework nanoparticles for magnetic resonance imaging. Inorganic Chemistry Frontiers. 2018;5:1760-1779. DOI: 10.1039/C8QI00149A'},{id:"B8",body:'Eddaoudi M, Li H, Yaghi OM. Highly porous and stable metal-organic frameworks: structure design and sorption properties. Journal of the American Chemical Society. 2000;122:1391-1397. DOI: 10.1021/ja9933386'},{id:"B9",body:'Horcajada P, Gref R, Baati T, Allan PK, Maurin G, Couvreur P, et al. Metal-organic frameworks in biomedicine. Chemical Reviews. 2012;112:1232-1268. DOI: 10.1021/cr200256v'},{id:"B10",body:'Simon-Yarza T, Mielcarek A, Couvreur P, Serre C. Nanoparticles of metal-organic frameworks: on the road to in vivo efficacy in biomedicine. Advanced Materials. 2018;30:e1707365. DOI: 10.1002/adma.201707365'},{id:"B11",body:'Zhang S, Pei X, Gao H, Chen S, Wang J. Metal-organic framework-based nanomaterials for biomedical applications. Chinese Chemical Letters. 2020;31:1060-1070. DOI: 10.1016/j.cclet.2019.11.036'},{id:"B12",body:'Riccò R, Liang W, Li S, Gassensmith JJ, Caruso F, Doonan C, et al. Metal-organic frameworks for cell and virus biology: A perspective. ACS Nano. 2018;12:13-23. DOI: 10.1021/acsnano.7b08056'},{id:"B13",body:'Alhamami M, Doan H, Cheng CH. A review on breathing behaviors of metal-organic-frameworks (MOFs) for gas adsorption. Materials (Basel). 2014;7:3198-3250. DOI: 10.3390/ma7043198'},{id:"B14",body:'Yaghi OM, O’Keeffe M, Ockwig NW, Chae HK, Eddaoudi M, Kim J. Reticular synthesis and the design of new materials. Nature. 2003;423:705-714. DOI: 10.1038/nature01650'},{id:"B15",body:'Yaghi OM, Kalmutzki MJ, Diercks CS. Introduction to Reticular Chemistry: Metal-Organic Frameworks and Covalent Organic Frameworks. Wiley; 2019. DOI: 10.1002/9783527821099. Available from: https://onlinelibrary.wiley.com/doi/book/10.1002/9783527821099'},{id:"B16",body:'Kalmutzki MJ, Hanikel N, Yaghi OM. Secondary building units as the turning point in the development of the reticular chemistry of MOFs. Science Advances. 2018;4:eaat9180. DOI: 10.1126/sciadv.aat9180'},{id:"B17",body:'Lawson HD, Walton SP, Chan C. Metal-organic frameworks for drug delivery: A design perspective. ACS Applied Materials & Interfaces. 2021;13:7004-7020. DOI: 10.1021/acsami.1c01089'},{id:"B18",body:'Rocca JD, Liu D, Lin W. Nanoscale metal-organic frameworks for biomedical imaging and drug delivery. Accounts of Chemical Research. 2011;44:957-968. DOI: 10.1021/ar200028a'},{id:"B19",body:'Butova VV, Soldatov MA, Guda AA, Lomachenko KA, Lamberti C. Metal-organic frameworks: Structure, properties, methods of synthesis and characterization. Russian Chemical Reviews. 2016;85:280-307. DOI: 10.1070/RCR4554'},{id:"B20",body:'Rieter WJ, Taylor KM, An H, Lin W, Lin W. Nanoscale metal-organic frameworks as potential multimodal contrast enhancing agents. Journal of the American Chemical Society. 2006;128:9024-9025. DOI: 10.1021/ja0627444'},{id:"B21",body:'Taylor-Pashow KM, Della Rocca J, Xie Z, Tran S, Lin W. Postsynthetic modifications of iron-carboxylate nanoscale metal-organic frameworks for imaging and drug delivery. Journal of the American Chemical Society. 2009;131:14261-14263. DOI: 10.1021/ja906198y'},{id:"B22",body:'Safarifard V, Morsali A. Applications of ultrasound to the synthesis of nanoscale metal-organic coordination polymers. Coordination Chemistry Reviews. 2015;292:1-14. DOI: 10.1016/j.ccr.2015.02.014'},{id:"B23",body:'Yang B, Shen M, Liu J, Ren F. Post-synthetic modification nanoscale metal-organic frameworks for targeted drug delivery in cancer cells. Pharmaceutical Research. 2017;34:2440-2450. DOI: 10.1007/s11095-017-2253-9'},{id:"B24",body:'Uemura K, Matsuda R, Kitagawa S. Flexible microporous coordination polymers. Journal of Solid State Chemistry. 2005;178:2420-2429. DOI: 10.1016/j.jssc.2005.05.036'},{id:"B25",body:'Nasrollahi M, Nabipour H, Valizadeh N, Mozafari M. The Role of Flexibility in MOFs. Elsevier Inc; 2020. DOI: 10.1016/B978-0-12-816984-1.00006-8. Available from: https://www.sciencedirect.com/science/article/pii/B9780128169841000068?via%3Dihub'},{id:"B26",body:'Xu D, You Y, Zeng F, Wang Y, Liang C, Feng H, et al. Disassembly of hydrophobic photosensitizer by biodegradable zeolitic imidazolate framework-8 for photodynamic cancer therapy. ACS Applied Materials & Interfaces. 2018;10:15517-15523. DOI: 10.1021/acsami.8b03831'},{id:"B27",body:'Chen X, Tong R, Shi Z, Yang B, Liu H, Ding S, et al. MOF nanoparticles with encapsulated autophagy inhibitor in controlled drug delivery system for antitumor. ACS Applied Materials & Interfaces. 2017;10:2328-2337. DOI: 10.1021/acsami.7b16522'},{id:"B28",body:'Rieter WJ, Pott KM, Taylor KM, Lin W. Nanoscale coordination polymers for platinum-based anticancer drug delivery. Journal of the American Chemical Society. 2008;130:11584-11585. DOI: 10.1021/ja803383k'},{id:"B29",body:'Lu K, He C, Lin W. A chlorin-based nanoscale metal-organic framework for photodynamic therapy of Colon cancers. Journal of the American Chemical Society. 2015;137:7600-7603. DOI: 10.1021/jacs.5b04069'},{id:"B30",body:'Horcajada P, Serre C, Vallet-Regí M, Sebban M, Taulelle F, Férey G. Metal-organic frameworks as efficient materials for drug delivery. Angewandte Chemie (International Ed. in English). 2006;45:5974-5978. DOI: 10.1002/anie.200601878'},{id:"B31",body:'Wang S, McGuirk CM, Ross MB, Wang S, Chen P, Xing H, et al. General and direct method for preparing oligonucleotide-functionalized metal-organic framework nanoparticles. Journal of the American Chemical Society. 2017;139:9827-9830. DOI: 10.1021/jacs.7b05633'},{id:"B32",body:'Zhu X, Gu J, Wang Y, Li B, Li Y, Zhao W, et al. Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release. Chemical Communications. 2014;50:8779-8782. DOI: 10.1039/C4CC02570A'},{id:"B33",body:'Röder R, Preiß T, Hirschle P, Steinborn B, Zimpel A, Höhn M, et al. Multifunctional nanoparticles by coordinative self-assembly of his-tagged units with metal-organic frameworks. Journal of the American Chemical Society. 2017;139:2359-2368. DOI: 10.1021/jacs.6b11934'},{id:"B34",body:'Zhang FM, Dong H, Zhang X, Sun XJ, Liu M, Yang DD, et al. Postsynthetic modification of ZIF-90 for potential targeted codelivery of two anticancer drugs. ACS Applied Materials & Interfaces. 2017;9:27332-27337. DOI: 10.1021/acsami.7b08451'},{id:"B35",body:'Zhuang J, Kuo CH, Chou LY, Liu DY, Weerapana E, Tsung CK. Optimized metal-organic-framework nanospheres for drug delivery: Evaluation of small-molecule encapsulation. ACS Nano. 2014;8:2812-2819. DOI: 10.1021/nn406590q'},{id:"B36",body:'Xue T, Xu C, Wang Y, Wang Y, Tian H, Zhang Y. Doxorubicin-loaded nanoscale metal-organic framework for tumor-targeting and combined chemotherapy and chemodynamic therapy. Biomaterials Science. 2019;7:4615-4623. DOI: 10.1039/C9BM01044K'},{id:"B37",body:'Lei B, Wang M, Jiang Z, Qi W, Su R, He Z. Constructing redox-responsive metal-organic framework nanocarriers for anticancer drug delivery. ACS Applied Materials & Interfaces. 2018;10:16698-16706. DOI: 10.1021/acsami.7b19693'},{id:"B38",body:'Liang K, Ricco R, Doherty CM, Styles MJ, Bell S, Kirby N, et al. Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules. Nature Communications. 2015;6:7240. DOI: 10.1038/ncomms8240'},{id:"B39",body:'Yang Y, Hu Q, Zhang Q, Jiang K, Lin W, Yang Y, et al. A large capacity cationic metal-organic framework nanocarrier for physiological pH responsive drug delivery. Molecular Pharmaceutics. 2016;13:2782-2786. DOI: 10.1021/acs.molpharmaceut.6b00374'},{id:"B40",body:'Eddaoudi M, Kim J, Rosi N, Vodak D, Wachter J, O’Keeffe M, et al. Systematic deign of pore size and functionality in isoreticular MOFs and their application in methane storage. Science. 2002;295:469-472. DOI: 10.1126/science.1067208'},{id:"B41",body:'Suh MP, Park HJ, Prasad TK, Lim DW. Hydrogen storage in metal-organic frameworks. Chemical Reviews. 2012;112:782-835. DOI: 10.1021/cr200274s'},{id:"B42",body:'Sumida K, Rogow DL, Mason JA, McDonald TM, Bloch ED, Herm ZR, et al. Carbon dioxide capture in metal-organic frameworks. Chemical Reviews. 2012;112:724-781. DOI: 10.1021/cr2003272'},{id:"B43",body:'Seo JS, Whang D, Lee H, Jun SI, Oh J, Jeon YJ, et al. A homochiral metal-organic porous material for enantioselective separation and catalysis. Nature. 2000;404:982-986. DOI: 10.1038/35010088'},{id:"B44",body:'Lv XL, Wang K, Wang B, Su J, Zou X, Xie Y, et al. A base-resistant metalloporphyrin metal-organic framework for C-H bond halogenation. Journal of the American Chemical Society. 2017;139:211-217. DOI: 10.1021/jacs.6b09463'},{id:"B45",body:'Li K, He K, Li Q, Xia B, Wang Q, Zhang Y. A zinc(II) MOF based on secondary building units of infinite wavy-shaped chain exhibiting obvious luminescent sense effects. Chinese Chemical Letters. 2019;30:499-501. DOI: 10.1016/j.cclet.2018.05.001'},{id:"B46",body:'Kurmoo M. Magnetic metal-organic frameworks. Chemical Society Reviews. 2009;38:1353-1379. DOI: 10.1039/B804757J'},{id:"B47",body:'Zhang T, Lin W. Metal-organic frameworks for artificial photosynthesis and photocatalysis. Chemical Society Reviews. 2014;43:5982-5993. DOI: 10.1039/C4CS00103F'},{id:"B48",body:'Ling P, Lei J, Zhang L, Ju H. Porphyrin-encapsulated metal-organic frameworks as mimetic catalysts for electrochemical DNA sensing via allosteric switch of hairpin DNA. Analytical Chemistry. 2015;87:3957-3963. DOI: 10.1021/acs.analchem.5b00001'},{id:"B49",body:'Horcajada P, Chalati T, Serre C, Gillet B, Sebrie C, Baati T, et al. Porous metal-organic frameworks nanoscale carriers as a potential platform for drug delivery and imaging. Nature Materials. 2010;9:172-179. DOI: 10.1038/nmat2608'},{id:"B50",body:'Ishida T, Harashima H, Kiwada H. Liposome Clearance. Bioscience Reports. 2002;22:197-224. DOI: 10.1023/A:1020134521778'},{id:"B51",body:'Soenen SJ, Parak WJ, Rejman J, Manshian B. (Intra) cellular stability of inorganic nanoparticles: effects on cytotoxicity, particle functionality, and biomedical applications. Chemical Reviews. 2015;115:2109-2135. DOI: 10.1021/cr400714j'},{id:"B52",body:'Nasrabadi M, Ghasemzadeh MA, Zand Monfared MR. The preparation and characterization of UiO-66 metal-organic frameworks for the delivery of the drug ciprofloxacin and an evaluation of their antibacterial activities. New Journal of Chemistry. 2019;43:16033-16040. DOI: 10.1039/C9NJ03216A'},{id:"B53",body:'Sun CY, Qin C, Wang XL, Yang GS, Shao KZ, Lan YQ, et al. Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle. Dalton Transactions. 2012;41:6906-6909. DOI: 10.1039/C2DT30357D'},{id:"B54",body:'Horcajada P, Serre C, Maurin G, Ramsahye NA, Balas F, Vallet-Regí M, et al. Flexible porous metal-organic frameworks for a controlled drug delivery. Journal of the American Chemical Society. 2008;130:6774-6780. DOI: 10.1021/ja710973k'},{id:"B55",body:'Suresh K, Matzger AJ. Enhanced drug delivery by dissolution of amorphous drug encapsulated in a water unstable metal-organic framework (MOF). Angewandte Chemie (International Ed. in English). 2019;58:16790-16794. DOI: 10.1002/anie.201907652'},{id:"B56",body:'Jiang K, Zhang L, Hu Q, Zhao D, Xia T, Lin W, et al. Pressure controlled drug release in a Zr-cluster-based MOF. Journal of Materials Chemistry B. 2016;4:6398-6401. DOI: 10.1039/C6TB01756H'},{id:"B57",body:'Levine DJ, Runčevski T, Kapelewski MT, Keitz BK, Oktawiec J, Reed DA, et al. Olsalazine-based metal-organic frameworks as biocompatible platforms for H2 adsorption and drug delivery. Journal of the American Chemical Society. 2016;138:10143-10150. DOI: 10.1021/jacs.6b03523'},{id:"B58",body:'Lin S, Liu X, Tan L, Cui Z, Yang X, Yeung KWK, et al. Porous iron-carboxylate metal-organic framework: A novel bioplatform with sustained antibacterial efficacy and nontoxicity. ACS Applied Materials & Interfaces. 2017;9:19248-19257. DOI: 10.1021/acsami.7b04810'},{id:"B59",body:'Soltani B, Nabipour H, Nasab NA. Efficient storage of gentamicin in nanoscale zeolitic imidazolate framework-8 nanocarrier for pH-responsive drug release. Journal of Inorganic and Organometallic Polymers and Materials. 2018;28:1090-1097. DOI: 10.1007/s10904-017-0745-z'},{id:"B60",body:'Nabipour H, Sadr MH, Bardajee GR. Synthesis and characterization of nanoscale zeolitic imidazolate frameworks with ciprofloxacin and their applications as antimicrobial agents. New Journal of Chemistry. 2017;41:7364-7370. DOI: 10.1039/C7NJ00606C'},{id:"B61",body:'Sava Gallis DF, Butler KS, Agola JO, Pearce CJ, McBride AA. Antibacterial countermeasures via metal-organic framework-supported sustained therapeutic release. ACS Applied Materials & Interfaces. 2019;11:7782-7791. DOI: 10.1021/acsami.8b21698'},{id:"B62",body:'Zhang X, Liu L, Huang L, Zhang W, Wang R, Yue T, et al. The highly efficient elimination of intracellular bacteria via a metal organic framework (MOF)-based three-in-one delivery system. Nanoscale. 2019;11:9468-9477. DOI: 10.1039/C9NR01284B'},{id:"B63",body:'Wei Y, Chen C, Zhai S, Tan M, Zhao J, Zhu X, et al. Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release. Drug Delivery. 2021;28:372-379. DOI: 10.1080/10717544.2021.1879316'},{id:"B64",body:'André V, da Silva ARF, Fernandes A, Frade R, Garcia C, Rijo P, et al. Mg- and Mn-MOFs boost the antibiotic activity of nalidixic acid. ACS Applied Bio Materials. 2019;2:2347-2354. DOI: 10.1021/acsabm.9b00046'},{id:"B65",body:'Anand R, Borghi F, Manoli F, Manet I, Agostoni V, Reschiglian P, et al. Host-guest interactions in Fe(III)-trimesate MOF nanoparticles loaded with doxorubicin. The Journal of Physical Chemistry. B. 2014;118:8532-8539. DOI: 10.1021/jp503809w'},{id:"B66",body:'Lin W, Hu Q, Jiang K, Yang Y, Yang Y, Cui Y, et al. A porphyrin-based metal-organic framework as a pH-responsive drug carrier. Journal of Solid State Chemistry. 2016;237:307-312. DOI: 10.1016/j.jssc.2016.02.040'},{id:"B67",body:'Imaz I, Rubio-Martínez M, García-Fernández L, García F, Ruiz-Molina D, Hernando J, et al. Coordination polymer particles as potential drug delivery systems. Chemical Communications. 2010;46:4737-4739. DOI: 10.1039/C003084H'},{id:"B68",body:'Ke F, Yuan YP, Qiu LG, Shen YH, Xie AJ, Zhu JF, et al. Facile fabrication of magnetic metal-organic framework nanocomposites for potential targeted drug delivery. Journal of Materials Chemistry. 2011;21:3843-3848. DOI: 10.1039/C0JM01770A'},{id:"B69",body:'Lin W, Hu Q, Yu J, Jiang K, Yang Y, Xiang S, et al. Low cytotoxic metal-organic frameworks as temperature-responsive drug carriers. ChemPlusChem. 2016;81:804-810. DOI: 10.1002/cplu.201600142'},{id:"B70",body:'Gao S, Jin Y, Ge K, Li Z, Liu H, Dai X, et al. Self-supply of O2 and H2O2 by a nanocatalytic medicine to enhance combined chemo/chemodynamic therapy. Advancement of Science. 2019;6:1902137. DOI: 10.1002/advs.201902137'},{id:"B71",body:'Zheng H, Zhang Y, Liu L, Wan W, Guo P, Nyström AM, et al. One-pot synthesis of metal-organic frameworks with encapsulated target molecules and their applications for controlled drug delivery. Journal of the American Chemical Society. 2016;138:962-968. DOI: 10.1021/jacs.5b11720'},{id:"B72",body:'Chen G, Luo J, Cai M, Qin L, Wang Y, Gao L, et al. Investigation of metal-organic framework-5 (MOF-5) as an antitumor drug oridonin sustained release carrier. Molecules. 2019;24:3369. DOI: 10.3390/molecules24183369'},{id:"B73",body:'An H, Li M, Gao J, Zhang Z, Ma S, Chen Y. Incorporation of biomolecules in metal-organic frameworks for advanced applications. Coordination Chemistry Reviews. 2019;384:90-106. DOI: 10.1016/j.ccr.2019.01.001'},{id:"B74",body:'Chen Y, Li P, Modica JA, Drout RJ, Farha OK. Acid-resistant mesoporous metal-organic framework toward oral insulin delivery: Protein encapsulation, protection, and release. Journal of the American Chemical Society. 2018;140:5678-5681. DOI: 10.1021/jacs.8b02089'},{id:"B75",body:'Ni K, Luo T, Culbert A, Kaufmann M, Jiang X, Lin W. Nanoscale metal-organic framework co-delivers TLR-7 agonists and anti-CD47 antibodies to modulate macrophages and orchestrate cancer immunotherapy. Journal of the American Chemical Society. 2020;142:12579-12584. DOI: 10.1021/jacs.0c05039'},{id:"B76",body:'Morris W, Briley WE, Auyeung E, Cabezas MD, Mirkin CA. Nucleic acid-metal organic framework (MOF) nanoparticle conjugates. Journal of the American Chemical Society. 2014;136:7261-7264. DOI: 10.1021/ja503215w'},{id:"B77",body:'Shieh FK, Wang SC, Yen CI, Wu CC, Dutta S, Chou LY, et al. Imparting functionality to biocatalysts via embedding enzymes into nanoporous materials by a de novo approach: size-selective sheltering of catalase in metal-organic framework microcrystals. Journal of the American Chemical Society. 2015;137:4276-4279. DOI: 10.1021/ja513058h'},{id:"B78",body:'An J, Geib SJ, Rosi NL. Cation-triggered drug release from a porous zinc-adeninate metal-organic framework. Journal of the American Chemical Society. 2009;131:8376-8377. DOI: 10.1021/ja902972w'},{id:"B79",body:'Chen Y, Lykourinou V, Vetromile C, Hoang T, Ming LJ, Larsen RW, et al. How can proteins enter the interior of a MOF? investigation of cytochrome c translocation into a MOF consisting of mesoporous cages with microporous windows. Journal of the American Chemical Society. 2012;134:13188-13191. DOI: 10.1021/ja305144x'},{id:"B80",body:'Lykourinou V, Chen Y, Wang XS, Meng L, Hoang T, Ming LJ, et al. Immobilization of MP-11 into a mesoporous metal-organic framework, MP-11@mesoMOF: A new platform for enzymatic catalysis. Journal of the American Chemical Society. 2011;133:10382-10385. DOI: 10.1021/ja2038003'},{id:"B81",body:'Deng H, Grunder S, Cordova KE, Valente C, Furukawa H, Hmadeh M, et al. Large-pore apertures in a series of metal-organic frameworks. Science. 2012;336:1018-1023. DOI: 10.1126/science.1220131'},{id:"B82",body:'Lian X, Huang Y, Zhu Y, Fang Y, Zhao R, Joseph E, et al. Enzyme-MOF nanoreactor activates nontoxic paracetamol for cancer therapy. Angewandte Chemie (International Ed. in English). 2018;57:5725-5730. DOI: 10.1002/anie.201801378'},{id:"B83",body:'Wu X, Ge J, Yang C, Hou M, Liu Z. Facile synthesis of multiple enzyme-containing metal-organic frameworks in a biomolecule-friendly environment. Chemical Communications. 2015;51:13408-13411. DOI: 10.1039/C5CC05136C'},{id:"B84",body:'Peng S, Liu J, Qin Y, Wang H, Cao B, Lu L, et al. Metal-organic framework encapsulating hemoglobin as high-stable and long-circulating oxygen carriers o treat hemorrhagic shock. ACS Applied Materials & Interfaces. 2019;11:35604-35612. DOI: 10.1021/acsami.9b15037'},{id:"B85",body:'Zhang X, Zeng Y, Zheng A, Cai Z, Huang A, Zeng J, et al. A fluorescence based immunoassay for galectin-4 using gold nanoclusters and a composite consisting of glucose oxidase and a metal-organic framework. Microchimica Acta. 2017;184:1933-1940. DOI: 10.1007/s00604-017-2204-5'},{id:"B86",body:'Li Y, Xu N, Zhu W, Wang L, Liu B, Zhang J, et al. Nanoscale Melittin@Zeolitic imidazolate frameworks for enhanced anticancer activity and mechanism analysis. ACS Applied Materials & Interfaces. 2018;10:22974-22984. DOI: 10.1021/acsami.8b06125'},{id:"B87",body:'Liu X, Yan Z, Zhang Y, Liu Z, Sun Y, Ren J, et al. Two-dimensional metal-organic framework/enzyme hybrid nanocatalyst as a benign and self-activated Cascade reagent for in vivo wound healing. ACS Nano. 2019;13:5222-5230. DOI: 10.1021/acsnano.8b09501'},{id:"B88",body:'Zhou Y, Liu L, Cao Y, Yu S, He C, Chen X. A nanocomposite vehicle based on metal-organic framework nanoparticle incorporated biodegradable microspheres for enhanced oral insulin delivery. ACS Applied Materials & Interfaces. 2020;12:22581-22592. DOI: 10.1021/acsami.0c04303'},{id:"B89",body:'Feng Y, Wang H, Zhang S, Zhao Y, Gao J, Zheng Y, et al. Antibodies@MOFs: An in vitro protective coating for preparation and storage of biopharmaceuticals. Advanced Materials. 2018;31:1805148. DOI: 10.1002/adma.201805148'},{id:"B90",body:'Alsaiari SK, Qutub SS, Sun S, Baslyman W, Aldehaiman M, Alyami M, et al. Sustained and targeted delivery of checkpoint inhibitors by metal-organic frameworks for cancer immunotherapy. Science Advances. 2021;7:eabe7174. DOI: 10.1126/sciadv.abe7174'},{id:"B91",body:'Zhang Y, Wang F, Ju E, Liu Z, Chen Z, Ren J, et al. Metal-organic framework-based vaccine platforms for enhanced systemic immune and memory response. Advanced Functional Materials. 2016;26:6454-6461. DOI: 10.1002/adfm.201600650'},{id:"B92",body:'Xie W, Yin T, Chen YL, Zhu DM, Zan MH, Chen B, et al. Capture and “self-release” of circulating tumor cells using metal-organic framework materials. Nanoscale. 2019;11:8293-8303. DOI: 10.1039/C8NR09071H'},{id:"B93",body:'Qi Y, Wang L, Guo H, Pan Y, Xie Z, Jin N, et al. Antigen-enabled facile preparation of MOF nanovaccine to activate the complement system for enhanced antigen-mediated immune response. Biomaterials Science. 2019;7:4022-4026. DOI: 10.1039/C9BM01145E'},{id:"B94",body:'Miao YB, Pan WY, Chen KH, Wei HJ, Mi FL, Lu MY, et al. Engineering a nanoscale Al-MOF-armored antigen carried by a “Trojan Horse”-like platform for oral vaccination to induce potent and long-lasting immunity. Advanced Functional Materials. 2019;29:1904828. DOI: 10.1002/adfm.201904828'},{id:"B95",body:'Peng S, Bie B, Sun Y, Liu M, Cong H, Zhou W, et al. Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells. Nature Communications. 2018;9:1293. DOI: 10.1038/s41467-018-03650-w'},{id:"B96",body:'Li Y, Zhang K, Liu P, Chen M, Zhong Y, Ye Q, et al. Encapsulation of plasmid DNA by nanoscale metal-organic frameworks for efficient gene transportation and expression. Advanced Materials. 2019;31:1901570. DOI: 10.1002/adma.201901570'},{id:"B97",body:'Chen Q, Xu M, Zheng W, Xu T, Deng H, Liu J. Se/Ru-decorated porous metal-organic framework nanoparticles for the delivery of pooled siRNAs to reversing multidrug resistance in taxol-resistant breast cancer cells. ACS Applied Materials & Interfaces. 2017;9:6712-6724. DOI: 10.1021/acsami.6b12792'},{id:"B98",body:'Astria E, Thonhofer M, Ricco R, Liang W, Chemelli A, Tarzia A, et al. Carbohydrates@MOFs. Materials Horizons. 2019;6:969-977. DOI: 10.1039/C8MH01611A'},{id:"B99",body:'Zheng J, Li B, Ji Y, Chen Y, Lv X, Zhang X, et al. Prolonged release and shelf-life of anticoagulant sulfated polysaccharides encapsulated with ZIF-8. International Journal of Biological Macromolecules. 2021;183:1174-1183. DOI: 10.1016/j.ijbiomac.2021.05.007'},{id:"B100",body:'Velásquez-Hernández MDJ, Astria E, Winkler S, Liang W, Wiltsche H, Poddar A, et al. Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans. Chemical Science. 2020;11:10835-10843. DOI: 10.1039/D0SC01204A'},{id:"B101",body:'Sharma S, Mittal D, Verma AK, Roy I. Copper-gallic acid nanoscale metal-organic framework for combined drug delivery and photodynamic therapy. ACS Applied Bio Materials. 2019;2:2092-2101. DOI: 10.1021/acsabm.9b00116'},{id:"B102",body:'Chen J, Liu J, Hu Y, Tian Z, Zhu Y. Metal-organic framework-coated magnetite nanoparticles for synergistic magnetic hyperthermia and chemotherapy with pH-triggered drug release. Science and Technology of Advanced Materials. 2019;20:1043-1054. DOI: 10.1080/14686996.2019.1682467'},{id:"B103",body:'Sun Q, Bi H, Wang Z, Li C, Wang C, Xu J, et al. O2-generating metal-organic framework-based hydrophobic photosensitizer delivery system for enhanced photodynamic therapy. ACS Applied Materials & Interfaces. 2019;11:36347-36358. DOI: 10.1021/acsami.9b11607'},{id:"B104",body:'Zhang L, Gao Y, Sun S, Li Z, Wu A, Zeng L. pH-Responsive metal-organic framework encapsulated gold nanoclusters with modulated release to enhance photodynamic therapy/chemotherapy in breast cancer. Journal of Materials Chemistry B. 2020;8:1739-1747. DOI: 10.1039/C9TB02621E'},{id:"B105",body:'Liu J, Liu T, Du P, Zhang L, Lei J. Metal-organic framework (MOF) hybrid as a tandem catalyst for enhanced therapy against hypoxic tumor cells. Angewandte Chemie (International Ed. in English). 2019;58:7808-7812. DOI: 10.1002/anie.201903475'},{id:"B106",body:'Li Y, Xu N, Zhou J, Zhu W, Li L, Dong M, et al. Facile synthesis of a metal-organic framework nanocarrier or NIR imaging-guided photothermal therapy. Biomaterials Science. 2018;6:2918-2924. DOI: 10.1039/C8BM00830B'},{id:"B107",body:'Tian Z, Yao X, Ma K, Niu X, Grothe J, Xu Q, et al. Metal-organic framework/graphene quantum dot nanoparticles used for synergistic chemo- and photothermal therapy. ACS Omega. 2017;2:1249-1258. DOI: 10.1021/acsomega.6b00385'},{id:"B108",body:'Deng X, Liang S, Cai X, Huang S, Cheng Z, Shi Y, et al. Yolk-shell structured Au nanostar@metal-organic framework for synergistic chemo-photothermal therapy in the second near-infrared window. Nano Letters. 2019;19:6772-6780. DOI: 10.1021/acs.nanolett.9b01716'},{id:"B109",body:'Wang W, Wang L, Li Y, Liu S, Xie Z, Jing X. Nanoscale polymer metal-organic framework hybrids for effective photothermal therapy of Colon cancers. Advanced Materials. 2016;28:9320-9325. DOI: 10.1002/adma.201602997'},{id:"B110",body:'Huang J, Li N, Zhang C, Meng Z. Metal-organic framework as a microreactor for in situ fabrication of multifunctional nanocomposites for photothermal-chemotherapy of tumors in vivo. ACS Applied Materials & Interfaces. 2018;10:38729-38738. DOI: 10.1021/acsami.8b12394'},{id:"B111",body:'Xiang Z, Qi Y, Lu Y, Hu Z, Wang X, Jia W, et al. MOF-derived novel porous Fe3O4@C nanocomposites as smart nanomedical platforms or combined cancer therapy: magnetic-triggered synergistic hyperthermia and chemotherapy. Journal of Materials Chemistry B. 2020;8:8671-8683. DOI: 10.1039/D0TB01021A'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Ashi Mittal",address:null,affiliation:'
Department of Chemistry, University of Delhi, Delhi, India
Department of Chemistry, University of Delhi, Delhi, India
'}],corrections:null},book:{id:"11319",type:"book",title:"Drug Carriers",subtitle:null,fullTitle:"Drug Carriers",slug:null,publishedDate:null,bookSignature:"Dr. Luis Jesús Villarreal-Gómez",coverURL:"https://cdn.intechopen.com/books/images_new/11319.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-832-5",printIsbn:"978-1-80355-831-8",pdfIsbn:"978-1-80355-833-2",isAvailableForWebshopOrdering:!0,editors:[{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"325438",title:"Mrs.",name:"Ilaria",middleName:null,surname:"D’Angelo",email:"ilariadng3@gmail.com",fullName:"Ilaria D’Angelo",slug:"ilaria-d'angelo",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"74709",title:"Visual-Motor Perception and Handwriting Performance of Students with Mixed Subtype Dyslexia",slug:"visual-motor-perception-and-handwriting-performance-of-students-with-mixed-subtype-dyslexia",abstract:"This studyaimed to characterize and compare the visual-motor perception and handwriting performance of students with mixed dyslexia and students with good academic performance. Twenty-six schoolchildren of both sexes participated in this study, aged 9 to 11 years and 11 months old, from fourth and fifth grades of an elementary school in municipal public schools, from an average socioeconomic level, divided into two groups: Group I (GI) composed of 13 students with a multidisciplinary diagnosis of mixed developmental dyslexia and Group II (GII) composed of 13 students with good academic performance from a municipal school and matched according to gender, education, and age to GI. All students in this study were subjected to the application of the following procedures: Developmental Test of Visual Perception III—DTVP-III, Dysgraphia Scale and writing analysis by NeuroScript MovAlyzeR 6.1 software. The results were analyzed statistically using the following tests: Mann-Whitney test, Wilcoxon signed-rank test, and Friedman test, aiming to verify intragroup and intergroup differences for the variables of interest in the DTVP-III, the Dysgraphia Scale, and the measures of handwriting speed and pressure by the MovAlyzeR software. The results were analyzed statistically at a significance level of 5% (0.050). The results showed that there were statistically significant differences between GI and GII in the parameters of the Dysgraphia Scale, floating lines, irregular spaces between words, junction points, sudden movements, and dimension irregularities. GII showed a superior performance in relation to GI in the variables analyzed with the DTVP-III in visual-motor integration, reduced motricity perception, and general visual perception. There was no statistically significant difference between GI and GII in the variables analyzed by the MovAlyzeR software. The results of this study allowed us to conclude that students with mixed dyslexia present a lower performance profile than the students with good academic performance in general visual perception, reduced motricity visual perception, and visual-motor perception skills, which may be the cause of the quality of dysgraphic writing characterized by floating lines, irregular spaces, junction points, sudden movements, and dimension irregularities.",signatures:"Simone Aparecida Capellini, Larissa Sellin, Ilaria D’Angelo, Noemi Del Bianco, Catia Giaconi and Giseli Donadon Germano",authors:[{id:"325210",title:null,name:"Simone",surname:"Capellini",fullName:"Simone Capellini",slug:"simone-capellini",email:"sacap@uol.com.br"},{id:"325437",title:"Mrs.",name:"Larissa",surname:"Sellin",fullName:"Larissa Sellin",slug:"larissa-sellin",email:"larisellin@gmail.com"},{id:"325438",title:"Mrs.",name:"Ilaria",surname:"D’Angelo",fullName:"Ilaria D’Angelo",slug:"ilaria-d'angelo",email:"ilariadng3@gmail.com"},{id:"325440",title:"Dr.",name:"Noemi",surname:"Del Bianco",fullName:"Noemi Del Bianco",slug:"noemi-del-bianco",email:"noemi.delbianco@gmail.com"},{id:"325441",title:"Dr.",name:"Catia",surname:"Giaconi",fullName:"Catia Giaconi",slug:"catia-giaconi",email:"catia.giaconi@unimc.it"},{id:"325443",title:"Dr.",name:"Giseli Donadon",surname:"Germano",fullName:"Giseli Donadon Germano",slug:"giseli-donadon-germano",email:"giseliger@yahoo.com.br"}],book:{id:"10228",title:"Dyslexia",slug:"dyslexia",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"85131",title:"Prof.",name:"Diane",surname:"Montgomery",slug:"diane-montgomery",fullName:"Diane Montgomery",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Middlesex University",institutionURL:null,country:{name:"United Kingdom"}}},{id:"86215",title:"Dr.",name:"Ying-Fang",surname:"Sun",slug:"ying-fang-sun",fullName:"Ying-Fang Sun",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Yang Ming University Hospital",institutionURL:null,country:{name:"Taiwan"}}},{id:"312572",title:"Ph.D.",name:"Maria",surname:"Rontou",slug:"maria-rontou",fullName:"Maria Rontou",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Hellenic Open University",institutionURL:null,country:{name:"Greece"}}},{id:"323076",title:"Dr.",name:"Trevor",surname:"O’Brien",slug:"trevor-o'brien",fullName:"Trevor O’Brien",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"323851",title:"Dr.",name:"Ruth",surname:"Falzon",slug:"ruth-falzon",fullName:"Ruth Falzon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"323862",title:"Assistant Prof.",name:"Jane",surname:"Roitsch",slug:"jane-roitsch",fullName:"Jane Roitsch",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"324010",title:"Dr.",name:"Helen",surname:"Ross",slug:"helen-ross",fullName:"Helen Ross",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"325210",title:null,name:"Simone",surname:"Capellini",slug:"simone-capellini",fullName:"Simone Capellini",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sao Paulo State University",institutionURL:null,country:{name:"Brazil"}}},{id:"325437",title:"Mrs.",name:"Larissa",surname:"Sellin",slug:"larissa-sellin",fullName:"Larissa Sellin",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"331299",title:"Prof.",name:"Pei-Shan",surname:"Liao",slug:"pei-shan-liao",fullName:"Pei-Shan Liao",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000032Fh2FQAS/Profile_Picture_2022-03-18T09:39:41.jpg",biography:"Pei-Shan Liao, Ph.D. in Rural Sociology from Pennsylvania State University (2001), currently works at the Research Center for Humanities and Social Sciences, Academia Sinica, Taiwan. Her main research interests include Survey Methodology, Individual Well-being and Environmental Sociology. Her current project is “Public Attitudes to and Awareness of Water Resources”.",institutionString:"Research Center for Humanities and Social Sciences, Academia Sinica, Taiwan",institution:null}]},generic:{page:{slug:"why-publish-with-intechopen",title:"Why publish with IntechOpen?",intro:"
IntechOpen offers several publishing options to researchers and research groups looking for a professional partner with a wide, international reach. Our publishing options cover the breadth of scientific publications and ensure an appropriate outlet for your research.
",metaTitle:"Why publish with IntechOpen?",metaDescription:"IntechOpen offers publishing options to researchers and research groups looking for a professional partner with a wide, international reach. Our publishing options cover the breadth of scientific publications and ensure an appropriate outlet for your research.",metaKeywords:null,canonicalURL:"/page/why-publish-with-intechopen",contentRaw:'[{"type":"htmlEditorComponent","content":"
What makes IntechOpen such a good choice?
\\n\\n
\\n\\t
Proven world leader in Open Access book publishing with over 10 years experience
\\n\\t
Over 5,700 OA books published
\\n\\t
Most competitive prices in the market
\\n\\t
Compliant with OA funding requirements
\\n\\t
Optimized process enables publication in 8–12 months
\\n\\t
Personal support each step of the way
\\n\\t
+184,650 citations in Web of Science databases
\\n\\t
Strongest OA platform with over 180 million downloads
Proven world leader in Open Access book publishing with over 10 years experience
\n\t
Over 5,700 OA books published
\n\t
Most competitive prices in the market
\n\t
Compliant with OA funding requirements
\n\t
Optimized process enables publication in 8–12 months
\n\t
Personal support each step of the way
\n\t
+184,650 citations in Web of Science databases
\n\t
Strongest OA platform with over 180 million downloads
\n
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6669},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2457},{group:"region",caption:"Asia",value:4,count:12710},{group:"region",caption:"Australia and Oceania",value:5,count:1016},{group:"region",caption:"Europe",value:6,count:17716}],offset:12,limit:12,total:134176},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{"amp;sort":"dateEndThirdStepPublish",hasNoEditors:"0"},books:[{type:"book",id:"9985",title:"Geostatistics",subtitle:null,isOpenForSubmission:!0,hash:"423cb3896195a618c4acb493ce4fd23d",slug:null,bookSignature:"Prof. Jeffrey M. Yarus, Dr. Marko Maucec, Dr. Timothy C. Coburn and Associate Prof. Michael Pyrcz",coverURL:"https://cdn.intechopen.com/books/images_new/9985.jpg",editedByType:null,editors:[{id:"78011",title:"Prof.",name:"Jeffrey M.",surname:"Yarus",slug:"jeffrey-m.-yarus",fullName:"Jeffrey M. Yarus"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10845",title:"Marine Ecosystems - Biodiversity, Ecosystem Services and Human Impacts",subtitle:null,isOpenForSubmission:!0,hash:"727e7eb3d4ba529ec5eb4f150e078523",slug:null,bookSignature:"Dr. Ana M.M. Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10845.jpg",editedByType:null,editors:[{id:"320124",title:"Dr.",name:"Ana M.M.",surname:"Gonçalves",slug:"ana-m.m.-goncalves",fullName:"Ana M.M. Gonçalves"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11027",title:"Basics of Hypoglycemia",subtitle:null,isOpenForSubmission:!0,hash:"98ebc1e36d02be82c204b8fd5d24f97a",slug:null,bookSignature:"Dr. Alok Raghav",coverURL:"https://cdn.intechopen.com/books/images_new/11027.jpg",editedByType:null,editors:[{id:"334465",title:"Dr.",name:"Alok",surname:"Raghav",slug:"alok-raghav",fullName:"Alok Raghav"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11124",title:"Next-Generation Textiles",subtitle:null,isOpenForSubmission:!0,hash:"093f9e26bb829b8d414d13626aea1086",slug:null,bookSignature:"Dr. Hassan Ibrahim",coverURL:"https://cdn.intechopen.com/books/images_new/11124.jpg",editedByType:null,editors:[{id:"90645",title:"Dr.",name:"Hassan",surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11168",title:"Sulfur Industry",subtitle:null,isOpenForSubmission:!0,hash:"39d4f4522a9f465bfe15ec2d85ef8861",slug:null,bookSignature:"Dr. Enos Wamalwa Wambu and Dr. Esther Nthiga",coverURL:"https://cdn.intechopen.com/books/images_new/11168.jpg",editedByType:null,editors:[{id:"187655",title:"Dr.",name:"Enos",surname:"Wambu",slug:"enos-wambu",fullName:"Enos Wambu"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11273",title:"Ankylosing Spondylitis",subtitle:null,isOpenForSubmission:!0,hash:"e07e8cf78550507643fbcf71a6a9d48b",slug:null,bookSignature:"Dr. Jacome Bruges Armas",coverURL:"https://cdn.intechopen.com/books/images_new/11273.jpg",editedByType:null,editors:[{id:"70522",title:"Dr.",name:"Jacome",surname:"Bruges Armas",slug:"jacome-bruges-armas",fullName:"Jacome Bruges Armas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11369",title:"RNA Viruses",subtitle:null,isOpenForSubmission:!0,hash:"52f8a3a1486912beae40b34ac557fed3",slug:null,bookSignature:"Ph.D. Yogendra Shah",coverURL:"https://cdn.intechopen.com/books/images_new/11369.jpg",editedByType:null,editors:[{id:"278914",title:"Ph.D.",name:"Yogendra",surname:"Shah",slug:"yogendra-shah",fullName:"Yogendra Shah"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11433",title:"Human Migration in the Last Three Centuries",subtitle:null,isOpenForSubmission:!0,hash:"9836df9e82aa9f82e3852a60204909a8",slug:null,bookSignature:"Dr. Ingrid Muenstermann",coverURL:"https://cdn.intechopen.com/books/images_new/11433.jpg",editedByType:null,editors:[{id:"77112",title:"Dr.",name:"Ingrid",surname:"Muenstermann",slug:"ingrid-muenstermann",fullName:"Ingrid Muenstermann"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11434",title:"Indigenous Populations - Perspectives From Scholars and Practitioners in Contemporary Times",subtitle:null,isOpenForSubmission:!0,hash:"c0d1c1c93a36fd9d726445966316a373",slug:null,bookSignature:"Dr. Sylvanus Gbendazhi Barnabas",coverURL:"https://cdn.intechopen.com/books/images_new/11434.jpg",editedByType:null,editors:[{id:"293764",title:"Dr.",name:"Sylvanus",surname:"Barnabas",slug:"sylvanus-barnabas",fullName:"Sylvanus Barnabas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11436",title:"Beauty - Evolutionary, Social and Cultural Perspectives on Attractiveness",subtitle:null,isOpenForSubmission:!0,hash:"8f2773e5d4ffe767f38dd15712258e8c",slug:null,bookSignature:"Dr. Farid Pazhoohi",coverURL:"https://cdn.intechopen.com/books/images_new/11436.jpg",editedByType:null,editors:[{id:"470837",title:"Dr.",name:"Farid",surname:"Pazhoohi",slug:"farid-pazhoohi",fullName:"Farid Pazhoohi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11437",title:"Social Media - Risks and Opportunities",subtitle:null,isOpenForSubmission:!0,hash:"000e31f2e2f7295805e9a3864158ad63",slug:null,bookSignature:"Dr. Shafizan Mohamed and Dr. Shazleen Mohamed",coverURL:"https://cdn.intechopen.com/books/images_new/11437.jpg",editedByType:null,editors:[{id:"302450",title:"Associate Prof.",name:"Shafizan",surname:"Mohamed",slug:"shafizan-mohamed",fullName:"Shafizan Mohamed"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11438",title:"Fake News in the Era of Global Crises",subtitle:null,isOpenForSubmission:!0,hash:"5f61f975031e13ee705d8b5853f1aa58",slug:null,bookSignature:"Dr. David Eller",coverURL:"https://cdn.intechopen.com/books/images_new/11438.jpg",editedByType:null,editors:[{id:"476616",title:"Dr.",name:"Jack",surname:"Eller",slug:"jack-eller",fullName:"Jack Eller"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:38},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:13},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:24},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:65},{group:"topic",caption:"Environmental Sciences",value:12,count:10},{group:"topic",caption:"Immunology and Microbiology",value:13,count:16},{group:"topic",caption:"Materials Science",value:14,count:25},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:116},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:4},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:417},popularBooks:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11012",title:"Radiopharmaceuticals",subtitle:"Current Research for Better Diagnosis and Therapy",isOpenForSubmission:!1,hash:"f9046d6f96148b285e776f384991120d",slug:"radiopharmaceuticals-current-research-for-better-diagnosis-and-therapy",bookSignature:"Farid A. Badria",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4430},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"148",title:"Applied Microbiology",slug:"immunology-and-microbiology-applied-microbiology",parent:{id:"13",title:"Immunology and Microbiology",slug:"immunology-and-microbiology"},numberOfBooks:26,numberOfSeries:0,numberOfAuthorsAndEditors:860,numberOfWosCitations:964,numberOfCrossrefCitations:883,numberOfDimensionsCitations:1889,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"148",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"11006",title:"Disinfection of Viruses",subtitle:null,isOpenForSubmission:!1,hash:"d7f3f66e22e16c3751989918a43b3210",slug:"disinfection-of-viruses",bookSignature:"Raymond W. Nims and M. Khalid Ijaz",coverURL:"https://cdn.intechopen.com/books/images_new/11006.jpg",editedByType:"Edited by",editors:[{id:"104702",title:"Dr.",name:"Raymond W.",middleName:null,surname:"Nims",slug:"raymond-w.-nims",fullName:"Raymond W. Nims"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9614",title:"Advances in Candida albicans",subtitle:null,isOpenForSubmission:!1,hash:"31d6882518ca749b12715266eed0a018",slug:"advances-in-candida-albicans",bookSignature:"Xinhui Wang",coverURL:"https://cdn.intechopen.com/books/images_new/9614.jpg",editedByType:"Edited by",editors:[{id:"296531",title:"Dr.",name:"Xinhui",middleName:null,surname:"Wang",slug:"xinhui-wang",fullName:"Xinhui Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9403",title:"Human Microbiome",subtitle:null,isOpenForSubmission:!1,hash:"c31366ba82585ba3ac91d21eb1cf0a4d",slug:"human-microbiome",bookSignature:"Natalia V. Beloborodova and Andrey V. Grechko",coverURL:"https://cdn.intechopen.com/books/images_new/9403.jpg",editedByType:"Edited by",editors:[{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9521",title:"Antimicrobial Resistance",subtitle:"A One Health Perspective",isOpenForSubmission:!1,hash:"30949e78832e1afba5606634b52056ab",slug:"antimicrobial-resistance-a-one-health-perspective",bookSignature:"Mihai Mareș, Swee Hua Erin Lim, Kok-Song Lai and Romeo-Teodor Cristina",coverURL:"https://cdn.intechopen.com/books/images_new/9521.jpg",editedByType:"Edited by",editors:[{id:"88785",title:"Prof.",name:"Mihai",middleName:null,surname:"Mares",slug:"mihai-mares",fullName:"Mihai Mares"}],equalEditorOne:{id:"190224",title:"Dr.",name:"Swee Hua Erin",middleName:null,surname:"Lim",slug:"swee-hua-erin-lim",fullName:"Swee Hua Erin Lim",profilePictureURL:"https://mts.intechopen.com/storage/users/190224/images/system/190224.png",biography:"Dr. Erin Lim is presently working as an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates and is affiliated as an Associate Professor to Perdana University-Royal College of Surgeons in Ireland, Selangor, Malaysia. She obtained her Ph.D. from Universiti Putra Malaysia in 2010 with a National Science Fellowship awarded from the Ministry of Science, Technology and Innovation Malaysia and has been actively involved in research ever since. Her main research interests include analysis of carriage and transmission of multidrug resistant bacteria in non-conventional settings, besides an interest in natural products for antimicrobial testing. She is heavily involved in the elucidation of mechanisms of reversal of resistance in bacteria in addition to investigating the immunological analyses of diseases, development of vaccination and treatment models in animals. She hopes her work will support the discovery of therapeutics in the clinical setting and assist in the combat against the burden of antibiotic resistance.",institutionString:"Higher Colleges of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Perdana University",institutionURL:null,country:{name:"Malaysia"}}},equalEditorTwo:{id:"221544",title:"Dr.",name:"Kok-Song",middleName:null,surname:"Lai",slug:"kok-song-lai",fullName:"Kok-Song Lai",profilePictureURL:"https://mts.intechopen.com/storage/users/221544/images/system/221544.jpeg",biography:"Dr. Lai Kok Song is an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates. He obtained his Ph.D. in Biological Sciences from Nara Institute of Science and Technology, Japan in 2012. Prior to his academic appointment, Dr. Lai worked as a Senior Scientist at the Ministry of Science, Technology and Innovation, Malaysia. His current research areas include antimicrobial resistance and plant-pathogen interaction. His particular interest lies in the study of the antimicrobial mechanism via membrane disruption of essential oils against multi-drug resistance bacteria through various biochemical, molecular and proteomic approaches. Ultimately, he hopes to uncover and determine novel biomarkers related to antibiotic resistance that can be developed into new therapeutic strategies.",institutionString:"Higher Colleges of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Higher Colleges of Technology",institutionURL:null,country:{name:"United Arab Emirates"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8415",title:"Extremophilic Microbes and Metabolites",subtitle:"Diversity, Bioprospecting and Biotechnological Applications",isOpenForSubmission:!1,hash:"93e0321bc93b89ff73730157738f8f97",slug:"extremophilic-microbes-and-metabolites-diversity-bioprospecting-and-biotechnological-applications",bookSignature:"Afef Najjari, Ameur Cherif, Haïtham Sghaier and Hadda Imene Ouzari",coverURL:"https://cdn.intechopen.com/books/images_new/8415.jpg",editedByType:"Edited by",editors:[{id:"196823",title:"Dr.",name:"Afef",middleName:null,surname:"Najjari",slug:"afef-najjari",fullName:"Afef Najjari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8967",title:"Bacterial Biofilms",subtitle:null,isOpenForSubmission:!1,hash:"e692b520263526cca2b37092c3e8d0b4",slug:"bacterial-biofilms",bookSignature:"Sadik Dincer, Melis Sümengen Özdenefe and Afet Arkut",coverURL:"https://cdn.intechopen.com/books/images_new/8967.jpg",editedByType:"Edited by",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9294",title:"Fluorescence Methods for Investigation of Living Cells and Microorganisms",subtitle:null,isOpenForSubmission:!1,hash:"a97a566a3a19eb9e0c9ba61042bb06c5",slug:"fluorescence-methods-for-investigation-of-living-cells-and-microorganisms",bookSignature:"Natalia Grigoryeva",coverURL:"https://cdn.intechopen.com/books/images_new/9294.jpg",editedByType:"Edited by",editors:[{id:"239430",title:"Dr.",name:"Natalia",middleName:"Yu.",surname:"Grigoryeva",slug:"natalia-grigoryeva",fullName:"Natalia Grigoryeva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8422",title:"Metagenomics",subtitle:"Basics, Methods and Applications",isOpenForSubmission:!1,hash:"82c6409553747ffccd6075f9420e3175",slug:"metagenomics-basics-methods-and-applications",bookSignature:"Wael N. Hozzein",coverURL:"https://cdn.intechopen.com/books/images_new/8422.jpg",editedByType:"Edited by",editors:[{id:"189233",title:"Prof.",name:"Wael N.",middleName:"Nabil",surname:"Hozzein",slug:"wael-n.-hozzein",fullName:"Wael N. Hozzein"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6967",title:"Prebiotics and Probiotics",subtitle:"Potential Benefits in Nutrition and Health",isOpenForSubmission:!1,hash:"11781d6b1c070edcf204518e632033be",slug:"prebiotics-and-probiotics-potential-benefits-in-nutrition-and-health",bookSignature:"Elena Franco-Robles and Joel Ramírez-Emiliano",coverURL:"https://cdn.intechopen.com/books/images_new/6967.jpg",editedByType:"Edited by",editors:[{id:"219102",title:"Dr.",name:"Elena",middleName:null,surname:"Franco-Robles",slug:"elena-franco-robles",fullName:"Elena Franco-Robles"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8019",title:"Alginates",subtitle:"Recent Uses of This Natural Polymer",isOpenForSubmission:!1,hash:"61ea5c1aef462684a3b2215631b7dbf2",slug:"alginates-recent-uses-of-this-natural-polymer",bookSignature:"Leonel Pereira",coverURL:"https://cdn.intechopen.com/books/images_new/8019.jpg",editedByType:"Edited by",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8292",title:"Oral Health by Using Probiotic Products",subtitle:null,isOpenForSubmission:!1,hash:"327e750e83634800ace02fe62607c21e",slug:"oral-health-by-using-probiotic-products",bookSignature:"Razzagh Mahmoudi",coverURL:"https://cdn.intechopen.com/books/images_new/8292.jpg",editedByType:"Edited by",editors:[{id:"245925",title:"Dr.",name:"Razzagh",middleName:null,surname:"Mahmoudi",slug:"razzagh-mahmoudi",fullName:"Razzagh Mahmoudi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8107",title:"Yeasts in Biotechnology",subtitle:null,isOpenForSubmission:!1,hash:"b3b86676fec9c1a1f34c8bd00b16c11c",slug:"yeasts-in-biotechnology",bookSignature:"Thalita Peixoto Basso",coverURL:"https://cdn.intechopen.com/books/images_new/8107.jpg",editedByType:"Edited by",editors:[{id:"139174",title:"Ph.D.",name:"Thalita",middleName:null,surname:"Peixoto Basso",slug:"thalita-peixoto-basso",fullName:"Thalita Peixoto Basso"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:26,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"62553",doi:"10.5772/intechopen.79371",title:"Antibiotic Use in Poultry Production and Its Effects on Bacterial Resistance",slug:"antibiotic-use-in-poultry-production-and-its-effects-on-bacterial-resistance",totalDownloads:7230,totalCrossrefCites:43,totalDimensionsCites:86,abstract:"A surge in the development and spread of antibiotic resistance has become a major cause for concern. Over the past few decades, no major new types of antibiotics have been produced and almost all known antibiotics are increasingly losing their activity against pathogenic microorganisms. The levels of multi-drug resistant bacteria have also increased. It is known that worldwide, more than 60% of all antibiotics that are produced find their use in animal production for both therapeutic and non-therapeutic purposes. The use of antimicrobial agents in animal husbandry has been linked to the development and spread of resistant bacteria. Poultry products are among the highest consumed products worldwide but a lot of essential antibiotics are employed during poultry production in several countries; threatening the safety of such products (through antimicrobial residues) and the increased possibility of development and spread of microbial resistance in poultry settings. This chapter documents some of the studies on antibiotic usage in poultry farming; with specific focus on some selected bacterial species, their economic importance to poultry farming and reports of resistances of isolated species from poultry settings (farms and poultry products) to essential antibiotics.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Christian Agyare, Vivian Etsiapa Boamah, Crystal Ngofi Zumbi and\nFrank Boateng Osei",authors:[{id:"182058",title:"Dr.",name:"Christian",middleName:null,surname:"Agyare",slug:"christian-agyare",fullName:"Christian Agyare"},{id:"261271",title:"MSc.",name:"Crystal Ngofi",middleName:null,surname:"Zumbi",slug:"crystal-ngofi-zumbi",fullName:"Crystal Ngofi Zumbi"},{id:"261272",title:"MSc.",name:"Frank Boateng",middleName:null,surname:"Osei",slug:"frank-boateng-osei",fullName:"Frank Boateng Osei"},{id:"261273",title:"Dr.",name:"Vivian Etsiapa",middleName:null,surname:"Boamah",slug:"vivian-etsiapa-boamah",fullName:"Vivian Etsiapa Boamah"}]},{id:"39599",doi:"10.5772/50046",title:"Encapsulation Technology to Protect Probiotic Bacteria",slug:"encapsulation-technology-to-protect-probiotic-bacteria",totalDownloads:12380,totalCrossrefCites:43,totalDimensionsCites:83,abstract:null,book:{id:"3145",slug:"probiotics",title:"Probiotics",fullTitle:"Probiotics"},signatures:"María Chávarri, Izaskun Marañón and María Carmen Villarán",authors:[{id:"150285",title:"Dr.",name:"María",middleName:null,surname:"Chávarri Hueda",slug:"maria-chavarri-hueda",fullName:"María Chávarri Hueda"},{id:"151613",title:"MSc.",name:"Izaskun",middleName:null,surname:"Marañon",slug:"izaskun-maranon",fullName:"Izaskun Marañon"},{id:"151621",title:"Dr.",name:"Mª Carmen",middleName:null,surname:"Villarán",slug:"ma-carmen-villaran",fullName:"Mª Carmen Villarán"}]},{id:"39607",doi:"10.5772/50121",title:"Recent Application of Probiotics in Food and Agricultural Science",slug:"recent-application-of-probiotics-in-food-and-agricultural-science",totalDownloads:10144,totalCrossrefCites:29,totalDimensionsCites:74,abstract:null,book:{id:"3145",slug:"probiotics",title:"Probiotics",fullTitle:"Probiotics"},signatures:"Danfeng Song, Salam Ibrahim and Saeed Hayek",authors:[{id:"107905",title:"Prof.",name:"Salam",middleName:null,surname:"Ibrahim",slug:"salam-ibrahim",fullName:"Salam Ibrahim"},{id:"150202",title:"Dr.",name:"Danfeng",middleName:null,surname:"Song",slug:"danfeng-song",fullName:"Danfeng Song"},{id:"151025",title:"MSc.",name:"Saeed",middleName:null,surname:"Hayek",slug:"saeed-hayek",fullName:"Saeed Hayek"}]},{id:"51065",doi:"10.5772/63499",title:"Role of the Biofilms in Wastewater Treatment",slug:"role-of-the-biofilms-in-wastewater-treatment",totalDownloads:6802,totalCrossrefCites:27,totalDimensionsCites:59,abstract:"Biological wastewater treatment systems play an important role in improving water quality and human health. This chapter thus briefly discusses different biological methods, specially biofilm technologies, the development of biofilms on different filter media, factors affecting their development as well as their structure and function. It also tackles various conventional and modern molecular techniques for detailed exploration of the composition, diversity and dynamics of biofilms. These data are crucial to improve the performance, robustness and stability of biofilm-based wastewater treatment technologies.",book:{id:"5197",slug:"microbial-biofilms-importance-and-applications",title:"Microbial Biofilms",fullTitle:"Microbial Biofilms - Importance and Applications"},signatures:"Shama Sehar and Iffat Naz",authors:[{id:"180364",title:"Dr.",name:"Iffat",middleName:null,surname:"Naz",slug:"iffat-naz",fullName:"Iffat Naz"},{id:"183345",title:"Dr.",name:"Shama",middleName:null,surname:"Sehar",slug:"shama-sehar",fullName:"Shama Sehar"}]},{id:"49246",doi:"10.5772/61300",title:"Chitosan as a Biomaterial — Structure, Properties, and Electrospun Nanofibers",slug:"chitosan-as-a-biomaterial-structure-properties-and-electrospun-nanofibers",totalDownloads:4671,totalCrossrefCites:25,totalDimensionsCites:57,abstract:"Chitosan is a polysaccharide derived from chitin; chitin is the second most abundant polysaccharide in the world, after cellulose. Chitosan is biocompatible, biodegradable and non-toxic, so that it can be usedin medicalapplications such as antimicrobial and wound healing biomaterials. It also used as chelating agent due to its ability to bind with cholesterol, fats, proteins and metal ions.",book:{id:"4648",slug:"concepts-compounds-and-the-alternatives-of-antibacterials",title:"Concepts, Compounds and the Alternatives of Antibacterials",fullTitle:"Concepts, Compounds and the Alternatives of Antibacterials"},signatures:"H. M. Ibrahim and E.M.R. El- Zairy",authors:[{id:"90645",title:"Dr.",name:"Hassan",middleName:null,surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"},{id:"175694",title:"Dr.",name:"Enas",middleName:null,surname:"El- Zairy",slug:"enas-el-zairy",fullName:"Enas El- Zairy"}]}],mostDownloadedChaptersLast30Days:[{id:"65613",title:"The Methods for Detection of Biofilm and Screening Antibiofilm Activity of Agents",slug:"the-methods-for-detection-of-biofilm-and-screening-antibiofilm-activity-of-agents",totalDownloads:9163,totalCrossrefCites:13,totalDimensionsCites:21,abstract:"Biofilm producer microorganisms cause nosocomial and recurrent infections. Biofilm that is a sticky exopolysaccharide is the main virulence factor causing biofilm-related infections. Biofilm formation begins with attachment of bacteria to biotic surface such as host cell or abiotic surface such as prosthetic devices. After attachment, aggregation of bacteria is started by cell-cell adhesion. Aggregation continues with the maturation of biofilm. Dispersion is started by certain conditions such as phenol-soluble modulins (PSMs). By this way, sessile bacteria turn back into planktonic form. Bacteria embedded in biofilm (sessile form) are more resistant to antimicrobials than planktonic bacteria. So it is hard to treat biofilm-embedded bacteria than planktonic forms. For this reason, it is important to detect biofilm. There are a few biofilm detection and biofilm production methods on prosthetics, methods for screening antibacterial effect of agents against biofilm-embedded microorganism and antibiofilm effect of agents against biofilm production and mature biofilm. The aim of this chapter is to overview direct and indirect methods such as microscopy, fluorescent in situ hybridization, and Congo red agar, tube method, microtiter plate assay, checkerboard assay, plate counting, polymerase chain reaction, mass spectrometry, MALDI-TOF, and biological assays used by antibiofilm researches.",book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}]},{id:"62553",title:"Antibiotic Use in Poultry Production and Its Effects on Bacterial Resistance",slug:"antibiotic-use-in-poultry-production-and-its-effects-on-bacterial-resistance",totalDownloads:7236,totalCrossrefCites:43,totalDimensionsCites:86,abstract:"A surge in the development and spread of antibiotic resistance has become a major cause for concern. Over the past few decades, no major new types of antibiotics have been produced and almost all known antibiotics are increasingly losing their activity against pathogenic microorganisms. The levels of multi-drug resistant bacteria have also increased. It is known that worldwide, more than 60% of all antibiotics that are produced find their use in animal production for both therapeutic and non-therapeutic purposes. The use of antimicrobial agents in animal husbandry has been linked to the development and spread of resistant bacteria. Poultry products are among the highest consumed products worldwide but a lot of essential antibiotics are employed during poultry production in several countries; threatening the safety of such products (through antimicrobial residues) and the increased possibility of development and spread of microbial resistance in poultry settings. This chapter documents some of the studies on antibiotic usage in poultry farming; with specific focus on some selected bacterial species, their economic importance to poultry farming and reports of resistances of isolated species from poultry settings (farms and poultry products) to essential antibiotics.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Christian Agyare, Vivian Etsiapa Boamah, Crystal Ngofi Zumbi and\nFrank Boateng Osei",authors:[{id:"182058",title:"Dr.",name:"Christian",middleName:null,surname:"Agyare",slug:"christian-agyare",fullName:"Christian Agyare"},{id:"261271",title:"MSc.",name:"Crystal Ngofi",middleName:null,surname:"Zumbi",slug:"crystal-ngofi-zumbi",fullName:"Crystal Ngofi Zumbi"},{id:"261272",title:"MSc.",name:"Frank Boateng",middleName:null,surname:"Osei",slug:"frank-boateng-osei",fullName:"Frank Boateng Osei"},{id:"261273",title:"Dr.",name:"Vivian Etsiapa",middleName:null,surname:"Boamah",slug:"vivian-etsiapa-boamah",fullName:"Vivian Etsiapa Boamah"}]},{id:"65914",title:"Introductory Chapter: The Action Mechanisms of Antibiotics and Antibiotic Resistance",slug:"introductory-chapter-the-action-mechanisms-of-antibiotics-and-antibiotic-resistance",totalDownloads:4358,totalCrossrefCites:6,totalDimensionsCites:9,abstract:null,book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu, Nesrin Gareayaghi and Bekir S. Kocazeybek",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"},{id:"248288",title:"Prof.",name:"Bekir",middleName:null,surname:"Kocazeybek",slug:"bekir-kocazeybek",fullName:"Bekir Kocazeybek"},{id:"406463",title:"Dr.",name:"Nesrin",middleName:null,surname:"Gareayaghi",slug:"nesrin-gareayaghi",fullName:"Nesrin Gareayaghi"}]},{id:"50992",title:"Probiotics: A Comprehensive Review of Their Classification, Mode of Action and Role in Human Nutrition",slug:"probiotics-a-comprehensive-review-of-their-classification-mode-of-action-and-role-in-human-nutrition",totalDownloads:5381,totalCrossrefCites:15,totalDimensionsCites:27,abstract:"Probiotics are live microorganisms that live in gastrointestinal (GI) tract and are beneficial for their hosts and prevent certain diseases. In this chapter, after a complete introduction to probiotics, definition, mechanism of action, and their classification, currently used organisms will be discussed in detail. Moreover, different kinds of nutritional synthetic products of probiotics along with their safety and drug interaction will be noticed. This chapter mentions all clinical trial studies that have been done to evaluate probiotic efficacy with a focus on gastrointestinal diseases.",book:{id:"5193",slug:"probiotics-and-prebiotics-in-human-nutrition-and-health",title:"Probiotics and Prebiotics in Human Nutrition and Health",fullTitle:"Probiotics and Prebiotics in Human Nutrition and Health"},signatures:"Amirreza Khalighi, Reza Behdani and Shabnam Kouhestani",authors:[{id:"179560",title:"Dr.",name:"Amirreza",middleName:null,surname:"Khalighi",slug:"amirreza-khalighi",fullName:"Amirreza Khalighi"},{id:"185238",title:"Dr.",name:"Reza",middleName:null,surname:"Behdani",slug:"reza-behdani",fullName:"Reza Behdani"},{id:"185239",title:"Dr.",name:"Shabnam",middleName:null,surname:"Kouhestani",slug:"shabnam-kouhestani",fullName:"Shabnam Kouhestani"}]},{id:"72109",title:"Antibiotic Resistance in Biofilm",slug:"antibiotic-resistance-in-biofilm",totalDownloads:1445,totalCrossrefCites:11,totalDimensionsCites:18,abstract:"Biofilms can be found on several living and nonliving surfaces, which are formed by a group of microorganisms, complex assembly of proteins, polysaccharides, and DNAs in an extracellular polymeric matrix. By forming a biofilm, bacteria protect themselves from host defense, disinfectants, and antibiotics. Bacteria inside biofilm are much more resistant to antimicrobial agents than planktonic forms since bacteria that are unresisting to antimicrobial agents in any way can turn resistant after forming a biofilm. Low penetration of antibiotics into the biofilm, slow reproduction, and the existence of adaptive stress response constitute the multiphased defense of the bacterium. This antibiotic resistance, which is provided by biofilm, makes the treatments, which use effective antibiotic doses on the bacterium in planktonic shape, difficult. Biofilm formation potential of bacteria appears as an important virulence factor in ensuring the colonization on the living tissues or medical devices and makes the treatment difficult. The aim of this chapter is to overview the current knowledge of antimicrobial resistance mechanisms in biofilms.",book:{id:"8967",slug:"bacterial-biofilms",title:"Bacterial Biofilms",fullTitle:"Bacterial Biofilms"},signatures:"Sadık Dincer, Fatima Masume Uslu and Anil Delik",authors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"},{id:"315992",title:"MSc.",name:"Fatıma Masume",middleName:null,surname:"Uslu",slug:"fatima-masume-uslu",fullName:"Fatıma Masume Uslu"},{id:"315993",title:"MSc.",name:"Anıl",middleName:null,surname:"Delik",slug:"anil-delik",fullName:"Anıl Delik"}]}],onlineFirstChaptersFilter:{topicId:"148",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:36,paginationItems:[{id:"82195",title:"Endoplasmic Reticulum: A Hub in Lipid Homeostasis",doi:"10.5772/intechopen.105450",signatures:"Raúl Ventura and María Isabel Hernández-Alvarez",slug:"endoplasmic-reticulum-a-hub-in-lipid-homeostasis",totalDownloads:1,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82409",title:"Purinergic Signaling in Covid-19 Disease",doi:"10.5772/intechopen.105008",signatures:"Hailian Shen",slug:"purinergic-signaling-in-covid-19-disease",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82374",title:"The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma",doi:"10.5772/intechopen.105457",signatures:"Gilnei Bruno da Silva, Daiane Manica, Marcelo Moreno and Margarete Dulce Bagatini",slug:"the-potential-of-the-purinergic-system-as-a-therapeutic-target-of-natural-compounds-in-cutaneous-mel",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}}]},overviewPagePublishedBooks:{paginationCount:32,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. Dr. Suzuki currently serves as a visiting researcher at Kogakuin University, Japan, and also a vice president of the Japan Firefly Society.",institutionString:"Kogakuin University",institution:null}]}]},openForSubmissionBooks:{},onlineFirstChapters:{paginationCount:5,paginationItems:[{id:"82394",title:"Learning by Doing Active Social Learning",doi:"10.5772/intechopen.105523",signatures:"Anat Raviv",slug:"learning-by-doing-active-social-learning",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82310",title:"Knowledge of Intergenerational Contact to Combat Ageism towards Older People",doi:"10.5772/intechopen.105592",signatures:"Alice Nga Lai Kwong",slug:"knowledge-of-intergenerational-contact-to-combat-ageism-towards-older-people",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Social Aspects of Ageing - Selected Challenges, Analyses, and Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11479.jpg",subseries:{id:"90",title:"Human Development"}}},{id:"81993",title:"Emergent Chemistry: Using Visualizations to Develop Abstract Thinking and a Sense of Scale Within the Preschool Setting",doi:"10.5772/intechopen.105216",signatures:"Karina Adbo",slug:"emergent-chemistry-using-visualizations-to-develop-abstract-thinking-and-a-sense-of-scale-within-the",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"82252",title:"Early Childhood: Enriched Environments and Roles of Caring Adults",doi:"10.5772/intechopen.105157",signatures:"Analía Mignaton",slug:"early-childhood-enriched-environments-and-roles-of-caring-adults",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"81996",title:"Perspective Chapter: New Active Learning Models in Africa",doi:"10.5772/intechopen.105217",signatures:"Fred Awaah, Cosmas Lambini Kombat and Emmanuel Okyere Ekwam",slug:"perspective-chapter-new-active-learning-models-in-africa",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Active Learning - Research and Practice",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}}]},subseriesFiltersForOFChapters:[{caption:"Human Development",value:90,count:1,group:"subseries"},{caption:"Education",value:89,count:4,group:"subseries"}],publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",institutionString:"Université Laval",institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Business and Management",value:86,count:1}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1}],authors:{paginationCount:25,paginationItems:[{id:"429683",title:"Dr.",name:"Bilal",middleName:null,surname:"Khalid",slug:"bilal-khalid",fullName:"Bilal Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/429683/images/system/429683.png",biography:"Dr. Bilal Khalid received a Ph.D. in Industrial Business Administration from KMITL Business School, Bangkok, in 2021, and a master’s in International Business Management from Stamford International University, Bangkok, in 2017. Dr. Khalid\\'s research interests include leadership and negotiations, digital transformations, gamification, eLearning, blockchain, Big Data, and management of information technology. Dr. Bilal Khalid also serves as an academic editor at Education Research International and a reviewer for international journals.",institutionString:"KMITL Business School",institution:{name:"King Mongkut's Institute of Technology Ladkrabang",country:{name:"Thailand"}}},{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:"Université Laval",institution:{name:"Université Laval",country:{name:"Canada"}}},{id:"189147",title:"Dr.",name:"Hailan",middleName:null,surname:"Salamun",slug:"hailan-salamun",fullName:"Hailan Salamun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/189147/images/19274_n.jpeg",biography:"Hailan Salamun, (Dr.) was born in Selangor, Malaysia and graduated from Tunku Ampuan Jamaah Religious High School at Shah Alam. Obtained a degree from the International Islamic University (UIA), Gombak in the field of Islamic Revealed Knowledge and Heritage. Next, I furthered my studies to the professional level to obtain a Diploma in Education at UIA. After serving for several years in school, I furthered my studies to the Master of Dakwah and Leadership at Universiti Kebangsaan Malaysia (UKM), Bangi. I graduated with a Doctor of Philosophy in Principalship Leadership from the University of Malaya (UM) in 2010. I am currently a senior lecturer in the Department of Nationalism and Civilization, Center for Basic and Continuing Education, Universiti Malaysia Terengganu. Prior to that, I had served in several educational institutions such as schools, the Institute of Teacher Education (IPG), and also the University of Malaya. I am also actively involved in paper presentation, writing and publishing. My research interests are focused on leadership, education, society and Islamic civilization. This area of research requires a detailed understanding of Islamic studies and research studies in leadership. Another research interest that I have explored recently is the politics of the Malay community and also the leadership of the mosque.",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"442081",title:"Dr.",name:"Audrey",middleName:null,surname:"Addy",slug:"audrey-addy",fullName:"Audrey Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kwame Nkrumah University of Science and Technology",country:{name:"Ghana"}}},{id:"437993",title:"Mr.",name:"Job",middleName:null,surname:"Jackson",slug:"job-jackson",fullName:"Job Jackson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Management College of Southern Africa",country:{name:"South Africa"}}},{id:"428495",title:"Prof.",name:"Asyraf",middleName:null,surname:"Ab Rahman",slug:"asyraf-ab-rahman",fullName:"Asyraf Ab Rahman",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"429650",title:"Dr.",name:"Jacqueline",middleName:null,surname:"Kareem",slug:"jacqueline-kareem",fullName:"Jacqueline Kareem",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Christ University",country:{name:"India"}}},{id:"421041",title:"Dr.",name:"Sunil",middleName:null,surname:"Kumar Ramdas",slug:"sunil-kumar-ramdas",fullName:"Sunil Kumar Ramdas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jain University",country:{name:"India"}}},{id:"421833",title:"Mr.",name:"Eugene",middleName:null,surname:"Owusu-Acheampong",slug:"eugene-owusu-acheampong",fullName:"Eugene Owusu-Acheampong",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"239876",title:"Ph.D.",name:"Luciana",middleName:null,surname:"Mourão",slug:"luciana-mourao",fullName:"Luciana Mourão",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Salgado de Oliveira",country:{name:"Brazil"}}},{id:"421735",title:"Dr.",name:"elizabeth",middleName:null,surname:"addy",slug:"elizabeth-addy",fullName:"elizabeth addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"442083",title:"Dr.",name:"James",middleName:null,surname:"Addy",slug:"james-addy",fullName:"James Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"437991",title:"Prof.",name:"Muhammad",middleName:null,surname:"Hoque",slug:"muhammad-hoque",fullName:"Muhammad Hoque",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421006",title:"Dr.",name:"Anna",middleName:null,surname:"Uster",slug:"anna-uster",fullName:"Anna Uster",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470243",title:"Dr.",name:"Md Samim",middleName:null,surname:"Al Azad",slug:"md-samim-al-azad",fullName:"Md Samim Al Azad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470244",title:"Dr.",name:"Slimane",middleName:null,surname:"Ed-dafali",slug:"slimane-ed-dafali",fullName:"Slimane Ed-dafali",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421011",title:"Dr.",name:"Afatakpa",middleName:null,surname:"Fortune",slug:"afatakpa-fortune",fullName:"Afatakpa Fortune",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"446057",title:"Mr.",name:"Okedare",middleName:null,surname:"David Olubukunmi",slug:"okedare-david-olubukunmi",fullName:"Okedare David Olubukunmi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421778",title:"Dr.",name:"Fatimah",middleName:"Saeed",surname:"AlAhmari",slug:"fatimah-alahmari",fullName:"Fatimah AlAhmari",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421024",title:"Prof.",name:"Harold Andrew",middleName:null,surname:"Patrick",slug:"harold-andrew-patrick",fullName:"Harold Andrew Patrick",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421065",title:"Ms.",name:"Euzália",middleName:null,surname:"do Rosário Botelho Tomé",slug:"euzalia-do-rosario-botelho-tome",fullName:"Euzália do Rosário Botelho Tomé",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421053",title:"Associate Prof.",name:"Ken",middleName:null,surname:"Kalala Ndalamba",slug:"ken-kalala-ndalamba",fullName:"Ken Kalala Ndalamba",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421826",title:"Dr.",name:"Inusah",middleName:null,surname:"Salifu",slug:"inusah-salifu",fullName:"Inusah Salifu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"420823",title:"Prof.",name:"Gardênia da Silva",middleName:null,surname:"Abbad",slug:"gardenia-da-silva-abbad",fullName:"Gardênia da Silva Abbad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"437613",title:"MSc.",name:"Juliana",middleName:null,surname:"Legentil",slug:"juliana-legentil",fullName:"Juliana Legentil",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]}},subseries:{item:{id:"24",type:"subseries",title:"Computer Vision",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR",scope:"The scope of this topic is to disseminate the recent advances in the rapidly growing field of computer vision from both the theoretical and practical points of view. Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11420,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"1177",title:"Prof.",name:"Antonio",middleName:"J. R.",surname:"Neves",slug:"antonio-neves",fullName:"Antonio Neves",profilePictureURL:"https://mts.intechopen.com/storage/users/1177/images/system/1177.jpg",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"220565",title:"Dr.",name:"Jucheng",middleName:null,surname:"Yang",slug:"jucheng-yang",fullName:"Jucheng Yang",profilePictureURL:"https://mts.intechopen.com/storage/users/220565/images/5988_n.jpg",institutionString:null,institution:{name:"Tianjin University of Technology",institutionURL:null,country:{name:"China"}}},{id:"29299",title:"Prof.",name:"Serestina",middleName:null,surname:"Viriri",slug:"serestina-viriri",fullName:"Serestina Viriri",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOalQAG/Profile_Picture_1620817405517",institutionString:null,institution:{name:"University of KwaZulu-Natal",institutionURL:null,country:{name:"South Africa"}}},{id:"315933",title:"Dr.",name:"Yalın",middleName:null,surname:"Baştanlar",slug:"yalin-bastanlar",fullName:"Yalın Baştanlar",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002qpr7hQAA/Profile_Picture_1621430127547",institutionString:null,institution:{name:"Izmir Institute of Technology",institutionURL:null,country:{name:"Turkey"}}}]},onlineFirstChapters:{paginationCount:7,paginationItems:[{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? Empirical Evidence from an Emerging Economy",doi:"10.5772/intechopen.105589",signatures:"Bishnu Kumar Adhikary and Ranjan Kumar Mitra",slug:"does-board-structure-matter-in-csr-spending-of-commercial-banks-empirical-evidence-from-an-emerging-",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82395",title:"Toward a Better Understanding of Green Human Resource Management’s Impact on Green Competitive Advantage: A Conceptual Model",doi:"10.5772/intechopen.105528",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"toward-a-better-understanding-of-green-human-resource-management-s-impact-on-green-competitive-advan",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82269",title:"CSR Reporting and Blockchain Technology",doi:"10.5772/intechopen.105512",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Piyachart Phiromswad",slug:"csr-reporting-and-blockchain-technology",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82270",title:"From Corporate Social Opportunity to Corporate Social Responsibility",doi:"10.5772/intechopen.105445",signatures:"Brian Bolton",slug:"from-corporate-social-opportunity-to-corporate-social-responsibility",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82339",title:"Green Human Resource Management: An Exploratory Study from Moroccan ISO 14001 Certified Companies",doi:"10.5772/intechopen.105565",signatures:"Hosna Hossari and Kaoutar Elfahli",slug:"green-human-resource-management-an-exploratory-study-from-moroccan-iso-14001-certified-companies",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"82194",title:"CSR and Female Directors: A Review and Future Research Agenda",doi:"10.5772/intechopen.105112",signatures:"Pattarake Sarajoti, Pattanaporn Chatjuthamard, Suwongrat Papangkorn and Sirimon Treepongkaruna",slug:"csr-and-female-directors-a-review-and-future-research-agenda",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Corporate Social Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11602.jpg",subseries:{id:"86",title:"Business and Management"}}},{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},publishedBooks:{paginationCount:6,paginationItems:[{type:"book",id:"9493",title:"Periodontology",subtitle:"Fundamentals and Clinical Features",coverURL:"https://cdn.intechopen.com/books/images_new/9493.jpg",slug:"periodontology-fundamentals-and-clinical-features",publishedDate:"February 16th 2022",editedByType:"Edited by",bookSignature:"Petra Surlin",hash:"dfe986c764d6c82ae820c2df5843a866",volumeInSeries:8,fullTitle:"Periodontology - Fundamentals and Clinical Features",editors:[{id:"171921",title:"Prof.",name:"Petra",middleName:null,surname:"Surlin",slug:"petra-surlin",fullName:"Petra Surlin",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:"University of Medicine and Pharmacy of Craiova",institution:{name:"University of Medicine and Pharmacy of Craiova",institutionURL:null,country:{name:"Romania"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9588",title:"Clinical Concepts and Practical Management Techniques in Dentistry",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9588.jpg",slug:"clinical-concepts-and-practical-management-techniques-in-dentistry",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Aneesa Moolla",hash:"42deab8d3bcf3edf64d1d9028d42efd1",volumeInSeries:7,fullTitle:"Clinical Concepts and Practical Management Techniques in Dentistry",editors:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",institutionURL:null,country:{name:"South Africa"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8202",title:"Periodontal Disease",subtitle:"Diagnostic and Adjunctive Non-surgical Considerations",coverURL:"https://cdn.intechopen.com/books/images_new/8202.jpg",slug:"periodontal-disease-diagnostic-and-adjunctive-non-surgical-considerations",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Nermin Mohammed Ahmed Yussif",hash:"0aee9799da7db2c732be44dd8fed16d8",volumeInSeries:6,fullTitle:"Periodontal Disease - Diagnostic and Adjunctive Non-surgical Considerations",editors:[{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",institutionString:"MSA University",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8837",title:"Human Teeth",subtitle:"Key Skills and Clinical Illustrations",coverURL:"https://cdn.intechopen.com/books/images_new/8837.jpg",slug:"human-teeth-key-skills-and-clinical-illustrations",publishedDate:"January 22nd 2020",editedByType:"Edited by",bookSignature:"Zühre Akarslan and Farid Bourzgui",hash:"ac055c5801032970123e0a196c2e1d32",volumeInSeries:5,fullTitle:"Human Teeth - Key Skills and Clinical Illustrations",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:{id:"52177",title:"Prof.",name:"Farid",middleName:null,surname:"Bourzgui",slug:"farid-bourzgui",fullName:"Farid Bourzgui",profilePictureURL:"https://mts.intechopen.com/storage/users/52177/images/system/52177.png",biography:"Prof. Farid Bourzgui obtained his DMD and his DNSO option in Orthodontics at the School of Dental Medicine, Casablanca Hassan II University, Morocco, in 1995 and 2000, respectively. Currently, he is a professor of Orthodontics. He holds a Certificate of Advanced Study type A in Technology of Biomaterials used in Dentistry (1995); Certificate of Advanced Study type B in Dento-Facial Orthopaedics (1997) from the Faculty of Dental Surgery, University Denis Diderot-Paris VII, France; Diploma of Advanced Study (DESA) in Biocompatibility of Biomaterials from the Faculty of Medicine and Pharmacy of Casablanca (2002); Certificate of Clinical Occlusodontics from the Faculty of Dentistry of Casablanca (2004); University Diploma of Biostatistics and Perceptual Health Measurement from the Faculty of Medicine and Pharmacy of Casablanca (2011); and a University Diploma of Pedagogy of Odontological Sciences from the Faculty of Dentistry of Casablanca (2013). He is the author of several scientific articles, book chapters, and books.",institutionString:"University of Hassan II Casablanca",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Hassan II Casablanca",institutionURL:null,country:{name:"Morocco"}}},equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7060",title:"Gingival Disease",subtitle:"A Professional Approach for Treatment and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/7060.jpg",slug:"gingival-disease-a-professional-approach-for-treatment-and-prevention",publishedDate:"October 23rd 2019",editedByType:"Edited by",bookSignature:"Alaa Eddin Omar Al Ostwani",hash:"b81d39988cba3a3cf746c1616912cf41",volumeInSeries:4,fullTitle:"Gingival Disease - A Professional Approach for Treatment and Prevention",editors:[{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6668",title:"Dental Caries",subtitle:"Diagnosis, Prevention and Management",coverURL:"https://cdn.intechopen.com/books/images_new/6668.jpg",slug:"dental-caries-diagnosis-prevention-and-management",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Zühre Akarslan",hash:"b0f7667770a391f772726c3013c1b9ba",volumeInSeries:1,fullTitle:"Dental Caries - Diagnosis, Prevention and Management",editors:[{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",institutionString:"Gazi University",institution:{name:"Gazi University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:318,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/325438",hash:"",query:{},params:{id:"325438"},fullPath:"/profiles/325438",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()