Connected and automated vehicles (CAVs) have seen a rapid surge in interest over the past few years. A lot of focus is being placed on improving the efficiency and robustness of transportation systems by leveraging the sensors and capabilities of CAVs. However, the integration of CAVs into existing traffic infrastructure would give rise to certain issues that must be addressed before the CAVs can be seen ubiquitously on public roads. Since the highway networks are considered permanent investments that are expensive to build and maintain, the priority is to improve the efficiency of the current traffic system. This chapter explores the integration of two of the most common traffic management strategies, namely, ramp metering (RM) and route guidance (RG), into existing highway networks with human-driven vehicles (HDVs). The introduction of CAVs to public roads will engender issues pertaining to safe interactions between CAVs and HDVs. The later part of the chapter addresses the specific problems of improving highway on-ramp merging efficiency by optimally coordinating CAVs. The chapter concludes by presenting a scenario that requires an explicit consideration of interactions between HDVs and CAVs.