This chapter presents an integrated management approach exploiting the potentials of the new Cooperative Intelligent Transportation Systems (C-ITS) to meet the requirements of the next generation Public Transport (PT). This approach considers the additional complexity of electrification—for instance electric busses need to periodically recharge during operation using dedicated infrastructure. This not only can impact service level, but also extend operating costs with complex electric charges. We develop new strategies explicitly optimizing the interactions within the PT ecosystem consisting of vehicles, traffic signals, and e-bus charging infrastructure. To achieve these goals, we rely on vehicle control rather than on the use of transit signal priority, which in congested urban scenarios can have negative effects on overall traffic performance. The main research challenges are in formulating and solving complex multi-objective optimization problems and real-time control. The proposed system is tested and evaluated in simulation showing the benefits of electrified and cooperative bus systems.