List of the top ten chili pepper producing countries in 2019.
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These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"3128",leadTitle:null,fullTitle:"Tribology - Fundamentals and Advancements",title:"Tribology",subtitle:"Fundamentals and Advancements",reviewType:"peer-reviewed",abstract:"As the subject of tribology comprises lubrication, friction and wear of contact components highly relevant to practical applications, it challenges scientists from chemistry, physics and materials engineering around the world on todays sophisticated experimental and theoretical foundation to complex interdisciplinary research. Recent results and developments are preferably presented and evaluated in the context of established knowledge. Consisting of eleven chapters divided into the four parts of Lubrication and Properties of Lubricants, Boundary Lubrication Applications, Testing and Modeling, and Sustainability of Tribosystems, this textbook therefore merges basic concepts with new findings and approaches. 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Frank",dateSubmitted:"September 1st 2021",dateReviewed:"September 8th 2021",datePrePublished:"October 15th 2021",datePublished:"April 20th 2022",book:{id:"11032",title:"Bats",subtitle:"Disease-Prone but Beneficial",fullTitle:"Bats - Disease-Prone but Beneficial",slug:"bats-disease-prone-but-beneficial",publishedDate:"April 20th 2022",bookSignature:"Heimo Mikkola",coverURL:"https://cdn.intechopen.com/books/images_new/11032.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"144330",title:"Dr.",name:"Heimo",middleName:"Juhani",surname:"Mikkola",slug:"heimo-mikkola",fullName:"Heimo Mikkola"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"423579",title:"Dr.",name:"Craig L.",middleName:"L.",surname:"Frank",fullName:"Craig L. Frank",slug:"craig-l.-frank",email:"frank@fordham.edu",position:null,institution:{name:"Fordham University",institutionURL:null,country:{name:"United States of America"}}}]},book:{id:"11032",title:"Bats",subtitle:"Disease-Prone but Beneficial",fullTitle:"Bats - Disease-Prone but Beneficial",slug:"bats-disease-prone-but-beneficial",publishedDate:"April 20th 2022",bookSignature:"Heimo Mikkola",coverURL:"https://cdn.intechopen.com/books/images_new/11032.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"144330",title:"Dr.",name:"Heimo",middleName:"Juhani",surname:"Mikkola",slug:"heimo-mikkola",fullName:"Heimo Mikkola"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"12021",leadTitle:null,title:"Applied Probability Theory - New Perspectives, Recent Advances and Trends",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tProbability theory is a fascinating paradigm across the ages till modern times that includes essential theorems and diverse applications in all science. It is a branch of statistics, a science that employs mathematical methods of collection, organization, and interpretation of data, with applications in practically all scientific areas. When working with probability theory, we analyze random – or stochastic – phenomena and assess the likelihood that an event will occur. Topics chosen in this book will aim to serve the purpose of illustrating probability theory and stochastic variables and processes. As a matter of fact, the subject is very broad and could be developed surely in many manuals and research papers. Thus, the book will intend to be an introduction to this exciting, profound, and modern field of mathematics and knowledge. This book will aim to discuss some fundamental aspects of pure and applied probability theory and explore their use to solve a large array of problems, as we will see. As such, the book will be of interest to all scholars, researchers, and undergraduate and graduate students in pure and applied mathematics, classical and modern physics, engineering, computer science, and science in general.
",isbn:"978-1-83768-296-6",printIsbn:"978-1-83768-295-9",pdfIsbn:"978-1-83768-297-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"f6f474da3dbb92cb35aeabdcbbf8498e",bookSignature:"Dr. Abdo Abou Jaoudé",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12021.jpg",keywords:"Probability, Novel Models, Applications, Latest Trends, New Theorems, Simulations, Computer Science, Applications to Physics, Applications to Engineering, Pure Mathematics, Stochastic Processes, New Probability Axioms",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 2nd 2022",dateEndSecondStepPublish:"June 30th 2022",dateEndThirdStepPublish:"August 29th 2022",dateEndFourthStepPublish:"November 17th 2022",dateEndFifthStepPublish:"January 16th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"11 hours",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Abdo Abou Jaoudé is a pioneering Associate Professor of Mathematics and Statistics at Notre Dame University-Louaizé. He holds two PhDs in Mathematics and Prognostics from the Lebanese University and Aix-Marseille University. His research interests are in the field of mathematics.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"248271",title:"Dr.",name:"Abdo",middleName:null,surname:"Abou Jaoudé",slug:"abdo-abou-jaoude",fullName:"Abdo Abou Jaoudé",profilePictureURL:"https://mts.intechopen.com/storage/users/248271/images/system/248271.jpg",biography:"Abdo Abou Jaoudé has been teaching for many years and has a passion for researching and teaching mathematics. He is currently an Associate Professor of Mathematics and Statistics at Notre Dame University-Louaizé (NDU), Lebanon. He holds a BSc and an MSc in Computer Science from NDU, and three PhDs in Applied Mathematics, Computer Science, and Applied Statistics and Probability, all from Bircham International University through a distance learning program. He also holds two PhDs in Mathematics and Prognostics from the Lebanese University, Lebanon, and Aix-Marseille University, France. Dr. Abou Jaoudé's broad research interests are in the field of applied mathematics. He has published twenty-three international journal articles and six contributions to conference proceedings, in addition to seven books on prognostics, pure and applied mathematics, and computer science.",institutionString:"Notre Dame University - Louaize",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Notre Dame University – Louaize",institutionURL:null,country:{name:"Lebanon"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"15",title:"Mathematics",slug:"mathematics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"252211",firstName:"Sara",lastName:"Debeuc",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/252211/images/7239_n.png",email:"sara.d@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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The incidence, even in developing countries, has been reduced since the introduction of vaccines against hepatitis A.
The vaccine is recommended in two doses for children, starting at the age of 1.
Argentina and, more recently, Brazil have adopted the universal vaccination of all children upon 12 months of age in a single-dose regimen.
While dealing with hepatitis A diagnosis, be aware of the signs of acute hepatic encephalopathy, because although it is a rare complication, it may require hepatic transplantation.
\nHepatitis A is an acute viral disease caused by the hepatitis A virus (HAV), a picornavirus that infects only primates and has a low mutation rate compared to the other viruses capable of causing acute viral hepatitis [1, 2, 3].
\nThe hepatitis A virus is transmitted by the fecal-oral route, either through ingestion of contaminated food [1] and water [4] or person-to-person contact. It has the ability to survive on surfaces for up to 60 days, and it is relatively resistant to alcohol and ether. As a result, the hygiene of bathrooms and toys in day care facilities must be meticulous [2, 5, 6].
\nThe disease endemic character is related to poor sanitation conditions. That explains why its prevalence is higher in developing countries, where children generally become infected during the first years of life. That justifies the predominance of the asymptomatic form of the disease in such places [2].
\nAlthough it is related to inadequate sanitation conditions, there are records of the disease even in developed countries where the major concern is the people, mainly adults, who travel to exotic locations or developing countries. Besides that, some outbreaks due to food contamination are also described. Adult’s disease, unlike the one that occurs in children, is symptomatic in 80% of cases [2]. Fortunately, since the introduction of vaccines, there has been a progressive decrease in the number of the cases of hepatitis A [7].
\nHepatitis A virus (HAV) is one of the five etiological agents of viral hepatic inflammation (HAV, HBV, HCV, HDV, and HEV), whose incidence, according to the WHO, is sporadic and occurs in the form of epidemics around the whole world, which tend to present cyclical recurrences [8]. It belongs to the genus
HAV is described as being a naked virus; however, there is evidence that it can be released from a preinfected cell, through a non-lytic path, inside a small extracellular vesicle whose membrane surrounds the entire capsid and provides protection against the mechanisms of the host immune system [10].
\nThe HAV presents as a genetic material a single-strand RNA with positive polarity, which confers the ability to act as messenger RNA (mRNA) and to interact directly with the ribosome to initiate the synthesis of the viral proteins. Its genome is divided in three parts [11]:
Noncoding region 5′UTR covalently linked to viral protein VPg [11]
A single open reading frame (ORF) subdivided into P1, which encodes the viral capsid proteins (VP1, VP2, VP3, and VP4), and P2 and P3, which encode nonstructural proteins that act during viral multiplication [11]
Noncoding region 3′UTR which has a poly-A tail [11]
The HAV is transmitted through fecal-oral route; the individual becomes infected from the ingestion of water and food contaminated by fecal material from another individual who had been previously infected.
\nAfter ingestion, the virus falls into the blood vessels and, through the portal circulation, reaches the hepatocytes. The first contact occurs through the basolateral membrane of the hepatocytes in the space of Disse [9]. After the processes of adsorption, penetration, denudation, and synthesis of viral genome and viral proteins, the virus is assembled and released from the host cell through a non-cytolytic process and undergoes cell exocytosis [12]. This release can occur through the apical membrane of the hepatocyte, which will cause the new virus to go to the bile canaliculi and, consequently, be sent to the intestine along with the bile. In addition, the release can also occur by the basolateral membrane, which causes the virus to return to the bloodstream [10, 12].
\nAfter being sent to the intestine, the virus will be sent to the external environment through the feces. During excretion, a large amount of virus is eliminated. This starts about 10 days before the onset of clinical manifestations [13]. The period of greatest transmissibility occurs between the previous 15 days and 7 days after the onset of symptoms [4].
\nThe immune response built by the host leads to the destruction of the hepatocytes infected by the virus and causes the appearance of the symptoms and signs of the disease. The HAV’s slow replication does not appear to cause cytopathic effects [13].
\nIt is possible that several mechanisms are involved in the development of signs of the disease. In one study fibroblasts and peripheral blood lymphocytes from patients with acute hepatitis A were used to demonstrate that the IFN-γ produced by HAV-specific cytotoxic T lymphocytes might play an important role in the pathogenesis of the disease [14].
\nAnother analysis evidenced the presence of IFN-γ, TNF, IL-2, and IL-21 produced by polyfunctional CD4 + T cells. These results place the immune response modulated by CD4 + T lymphocytes as being more crucial in the control of HAV replication [15].
\nIn contrast to studies that propose that adaptive immunity is more important in the pathogenesis and resolution of hepatitis A, it has been proposed that cells of the innate immune system, especially natural killer and lymphokine-activated killer (LAK) cells, play a crucial role in hepatic cell damage, which is inflicted prior to that performed by cytotoxic T lymphocytes [16].
\nIn addition, there is an antibody-mediated response. HAV-specific immunoglobulin M (IgM) antibody and IgA antibodies can be detected, from the onset of the first clinical signs, in the patient’s serum or plasma during the acute phase of the disease. IgG antibodies appear 1 week after the onset of the disease and can be detected for years even after healing. IgG can also be detected in vaccinated individuals. IgM and IgG immunoglobulins can neutralize the virus by recognizing epitopes of the HAV’s structural proteins, VP1, VP2, and VP3, located in the capsid [17].
\nThe hepatitis A virus is distributed worldwide. However, the highest incidence of hepatitis A occurs in developing countries and in the ones with poor health conditions. In developed countries the disease acquired by traveler accounts for almost half of the cases reported.
\nThe introduction of universal vaccination of children can change this general picture. The implementation of this program may reduce the rate of seropositive children against hepatitis A virus [18].
\nLuxemburger and Dutta show Brazil as a country with high endemicity of hepatitis A, meaning that more than 90% of children between 5 and 14 years old were seropositive for hepatitis A [19].
\nAfter that date there have been modifications in epidemiology of this disease. Checking the Epidemiological Bulletin of the Ministry of Health of Brazil in 2018, it’s possible to notice that after 2007 the incidence rate of hepatitis A has shown a progressive tendency of falling, going from 7.1 cases to 1.0 per 100,000 inhabitants in 2017.
\nBetween 1997 and 2017, most cases of hepatitis A occurred in children under 10 years of age (53.8%). In the last 2 years, there has been not only an increase in the incidence of the disease among people from 20 to 39 years of age but also a modification in the route of contamination. There was a significant reduction in cases related to food contamination and an increase in those related to sexual transmission. The incidence reduction preceded the universal vaccine. Universal vaccination of children from 12 months onwards was introduced in Brazil’s vaccination calendar only in 2014 [20].
\nIn relation to hepatitis A mortality in Brazil, between 2000 and 2016, there were 1125 deaths associated with viral hepatitis A. There is no data yet to compare mortality after the onset of the universal vaccine of Brazilian children [20]. Considering the distribution of deaths associated with all viral hepatitis in Brazil between 2000 and 2016 (66,196 obits), the proportion of obits was 1.7% associated with viral hepatitis A; 21.4% to hepatitis B; 75.8% to hepatitis C; and 1.1% to hepatitis D. In the document there is no report of viral hepatitis E [20].
\nRecently, the person-to-person HAV outbreaks involving people who use drugs or people experiencing homelessness are ongoing in United States, and this could signal a shift in HAV infection epidemiology in the United States [21].
\nThe virus’s incubation period is long (15–50 days), and the first symptoms are non-specific and reminiscent of common viral disease. The following may be present: fever, malaise, headache, and abdominal pain. Eventually, jaundice, hepatomegaly, splenomegaly, and bradycardia can appear. The icteric phase has a variable duration, on average from 4 to 30 days, and is associated with dark urine and acholic stools. Laboratory elevation of aminotransferases and direct hyperbilirubinemia is observed [2].
\nHepatitis A can have different forms of evolution, although most patients progress to healing within 2 months. Approximately 10% of hepatitis A patients present a biphasic form, in which relapses are observed in the first 6 months of evolution. Other forms considered atypical [6] may also be observed as the prolonged form, in which the symptoms persist for up to 120 days [22], and the cholestatic form presents the following alterations: elevation of the direct fraction of bilirubin, presence of significant pruritus, malabsorption of nutrients, and weight loss. Fortunately, all these forms present evolution for healing. Only a small fraction of patients will develop acute liver failure that is associated with increased morbidity and mortality [22].
\nAccording to CDC [23], suspected hepatitis A occurs in the presence of a suggestive clinical picture, characterized by the presence of fever, headache, malaise, anorexia, nausea, vomiting, diarrhea, abdominal pain, or dark urine, associated with suggestive laboratory alterations of the direct bilirubin fraction or ALT > 200 IU/L, in the absence of another diagnosis that explains such alterations.
\nThe presence of immunoglobulin M (IgM) antibody against hepatitis A virus or viral RNA detection provides laboratory evidence for the diagnosis [23].
\nThe presence of sensorineural alterations should raise the suspicion of acute liver failure, and the diagnosis is confirmed if there is an association of sensory alterations with a high prothrombin time in more than 4–6 s (INR ≥ 1.5) [24, 25].
\nHepatitis A has no specific treatment, and usually only support and monitoring measures are adopted. Although the disease is self-limiting in the vast majority of cases, some patients develop severe hepatitis, which can lead to fulminant hepatic insufficiency, and need liver transplantation.
\nThe fulminant hepatic insufficiency diagnosis should be considered in those patients with viral hepatitis who present any alteration of consciousness accompanied by some coagulation disorder [23] characterized by INR ≥ 1.5. Those findings indicate hospitalization of the patient in an intensive care unit with possibility of transfer to a liver transplant center.
\nIt is important to be aware of the fact that the symptoms of fulminant hepatic insufficiency become noticeable late when most of the liver functions are already compromised [26]. And so, the patient need to be transferred to a transplant center as soon as possible if he or she presents metabolic acidosis with arterial pH < 7.3, arterial lactate > 3 mmol/L (27 mg/dL), INR > 6.5, creatinine > 3.4 mg/dL, and presence of grade 3 or 4 hepatic encephalopathy all within the 24-h period [25].
\nSpecial attention should also be given to the child who evolves with the cholestatic form due to the nutritional risk secondary to malabsorption of fat-soluble nutrients and vitamins. During disease, until the cholestasis is fully treated, it may be necessary to provide increased caloric intake in addition to vitamins A, D, and E. Nutritional care should be maintained until cholestasis improves [27].
\nThe Brazilian Ministry of Health advices that the prevention of the disease is best achieved by improving basic sanitation and personal hygiene conditions as follows [28]:
Wash the hands after going to the bathroom and before eating or preparing food [28].
Wash, with treated water, foods that are consumed raw [28].
Cook the food before eating it [28].
Wash dishes, glasses, cutlery, and bottles properly [28].
Avoid the construction of ditches near wells and river springs, so as not to compromise the water table that feeds the well [28].
If there is a patient with hepatitis A at home, use 2.5% sodium hypochlorite, or bleach when washing the restroom [28].
In nurseries, preschools, cafeterias, restaurants, and closed institutions, adopt strict hygiene measures, such as disinfection of objects, benches, and floors using 2.5% sodium hypochlorite or bleach [28].
As a prophylactic measure for travelers, the vaccine has replaced immunoglobulin (Ig). The protection achieved by Ig when used before exposure is approximately 80–90% [20], whereas a single dose of hepatitis A vaccine provides protection of 85% of cases in the first 6 weeks and up to 95–00% after this time period [29]. Postexposure prophylaxis (PEP) with hepatitis A vaccine prevents hepatitis A virus infection when administered within 2 weeks of exposure [25, 30]. The use of Ig for PEP is indicated in the following situations: children aged <12 months; immunocompromised people; patients with chronic liver disease; and those for whom the vaccine is contraindicated. For people over 40, immunoglobulin is preferred, but the vaccine can be used on a non-distant immunoglobulin obtained [25, 28]. The recommended dose of IG was modified to 0.1 mL/kg [30].
\nPre-exposure prevention for travelers aged 12 months to 40 years should be given by vaccination as soon as traveling to endemic sites is considered, and the second dose should be administered at the regular interval recommended by the vaccine manufacturer. The vaccine can be administered between 6 and 11 months for pre-exposure prophylaxis, but this dose should not be considered when the child initiates the usual vaccination schedule at 12 months of age. In the case of infants <6 months of age, Ig should be given. The dose in these cases depends on the duration of the trip: for trips with a duration of up to 1 month 0.1 mL/kg is recommended; and with longer duration, the dose will be 0.2 mL/kg repeated every 2 months until the end of the trip. Travelers aged >40 years, immunocompromised or with chronic liver disease, are recommended to be vaccinated against hepatitis A and use Ig at the dose of 0.1 mL/kg at the same time but applied at separate sites [30].
\nSince the introduction of vaccines, there has been a reduction in the prevalence of the disease. The vaccine is effective, even if given as a single dose, although it is usually recommended in two doses. The initial dose should be administered at 1 year of age, especially in endemic areas where contact with the virus is early. The booster dose may occur at varying intervals, usually 6–18 months after the first dose.
\nThe effectiveness of the single-dose vaccine was initially described among people vaccinated for travel to exotic locations or with inadequate sanitary conditions [31, 32]. In 2003 a randomized, double blind study in Nicaragua showed that one dose of the vaccine had good efficacy, reaching up to 100% of children after 6 weeks (95% CI: 79.8–100%) [29].
\nYoung children who present hepatitis A are asymptomatic and therefore able to spread the virus in the community. That is why universal vaccination of all children between 1 and 5 years of age is recommended in populations where the incidence of the disease is >20 cases/100,000 inhabitants. The monovalent vaccine (Havrix®, Vaqta®) should be administered via intramuscular injection in two doses at a 6- to 12-month interval between doses [21, 25].
\nIn 2005, Argentina adopted a universal vaccination schedule for children aged 12 months in a single dose, and since then the incidence of hepatitis A has decreased by >80% in all age groups [33, 34].
\nFor developing countries, this may be a cheaper and simpler strategy than two-dose schedules; however, it is necessary to deploy a surveillance system to determine in the long run whether the booster dose will be needed [34].
\nIn Brazil, the hepatitis A vaccine was added to the national immunization program (NIP) only in 2014. Universal vaccination of children with a single dose of the inactivated vaccine was adopted at 12 months of age. In an official document, the NIP undertook to monitor the epidemiological situation of hepatitis A, aiming at the definition of whether or not to include a second dose in the child’s immunization schedule [35].
\nThe United Nations (UN) reports that viral hepatitis is a serious threat to global health, mainly related to hepatitis B and C viruses that cause chronic liver disease. The UN estimates suggest that 325 million people are infected worldwide, with 70 million on the African continent alone. Although the reports focus on hepatitis B and C because of their chronicity, the UN and WHO are committed to reducing hepatitis A-related deaths by 10 percent by the year 2030. According to the WHO, viral hepatitis A is a viral infection of the disease. It can be eliminated from Africa with vaccination and improved sanitation and access to safe drinking water. This latter measure may also reduce the incidence of viral hepatitis E [36, 37].
\nIn order to make vaccination against HAV feasible for developing countries, it is necessary to evaluate effective and cost-effective strategies. Vizzotti et al. [38] evaluated the impact of single-dose vaccination in Argentina and found an impressive decline in hepatitis A cases accompanied by a decrease in medical and nonmedical costs in the first 5 years. The authors then suggested that this could be a simpler and less costly strategy thus becoming an economically viable alternative to other countries where hepatitis A is also endemic.
\nSince both the world population and the life expectancy are increasing, it’s imperative that new techniques, fast, accessible, and sensitive ones, are developed in order to guarantee accurate diagnosis and proper treatment to anyone who is suffering from a disease. With new technologies being released in a daily basis and several researches being done in fields like molecular diagnostics, immunodiagnostics, and gene therapy, it’s possible that this goal may be achieved within the following decades.
\nSo as to improve the diagnosis of hepatitis and several other diseases, either through the detection of pathogens or elements present due to the host’s immune response, it’s essential that new, highly sensitive tests become available in healthcare facilities, especially in endemic regions.
\nOne possibility is to use new techniques that are being developed and allow the detection of antibodies. One example is the capacitive immunosensor developed to detect anti-Zika virus and anti-chikungunya virus antibodies in low concentrations using microwire electrodes [39].
\nAnother possibility is to use the CRISPR-Cas technology to detect the pathogen’s genetic material. This technique was developed based on the analysis of a specific defense mechanism of bacteria and archaea, organisms in which clusters of regularly interspaced short palindromic repeats (CRISPR), a specific region of the DNA, are transcribed into CRISPR RNA (crRNA) when they are infected by viruses [40, 41]. When the crRNA and the trans-activating crRNA (tracrRNA) associate with Cas9, an enzyme, the crRNA-Cas9 complex will then target a foreign DNA and cut it [40, 41].
\nStudies have shown that, through modification, the CRISPR-Cas complex is capable of targeting RNA [42] and adapting to different intracellular environments, such as the eukaryotic one [43]. Other experiments with CRISPR-Cas demonstrate that it can detect both Zika virus and dengue virus, RNA viruses [44]. Besides, this last analysis has also shown that a test based on this technique would be fast and sensitive and the costs would be low [44].
\nRegarding the treatment, some studies have shown that genome editing using the CRISPR-Cas system might also allow the development of effective antiviral therapies. Experiments done in vitro using human cells demonstrate that this system can target herpesvirus and provide either clearance of some strains of this virus or cause decay in other strains’ replication [45]. Another work, by demonstrating that the CRISPR-Cas system was able to inhibit the accumulation of hepatitis B virus (HBV) DNA in human cells, has shown that this system has the capacity to be developed into an effective therapy for viral diseases [46].
\nNevertheless, to ensure a decrease in the number of people infected with hepatitis, it’s also important to develop strategies to prevent the spread of the virus. Since hepatitis A is transmitted through a fecal-oral pathway, to achieve this goal, it’s essential that the water used by the population receives proper treatment in order to guarantee that all the pathogenic organisms are eliminated. In this context, water and sanitation projects developed by humanitarian organizations can contribute to the decrease in the number of people infected with fecal-oral transmitted diseases.
\nSome examples are the water safety plans (WSPs), created by the World Health Organization, and the Sustainable Development Goal 6, created by the United Nations. The former focusses on assembling a team that will develop a WSP considering all the hazardous events that can affect the safety of a water supply so as to determine and validate control measures that will be used to develop and implement improvements, which ensure that the drinking water supply is safe and accepted by the population [47]. The latter sets the goals for the following decades and analyzes indicators in order to monitor and promote the implementation of plans of action made to ensure universal and equitable access to safe and affordable drinking water for all, access to adequate and equitable sanitation, hygiene for all, end open defecation [48], and several other measures that can help control fecal-oral transmitted diseases.
\nHepatitis A is a viral disease whose prevention is possible through improvements in basic sanitation and vaccination of the population. The vaccine provides good protection and is recommended in two doses for children, starting at the age of 1 year. The efficacy of the single-dose vaccine has been reported between people traveling to exotic locations and then by developing countries that have adopted this single-dose schedule. In those places where the single-dose schedule has been adopted, a surveillance system should be in place to determine whether the booster dose will be necessary over the long term. Patients with hepatitis A present evolution to the healing in the majority of the cases, but it is necessary to be aware that, in rare occasions, they can develop acute hepatic insufficiency, which is associated to greater morbimortality.
\nThe authors declare no conflict of interest.
Five major domesticated species of
Chili peppers are perennial woody plants grown as herbaceous annuals. It is said to be the first-ever domesticated crop in America [3]. The size of the plant can range from two to four feet tall, depending on the species. Typically, leaves are smooth, simple, entire, glabrous, and flat. The flowers are usually solitary, creamy white, and the seeds are straw-colored. Figure 2 highlights the different types of chili plants. In addition, chili plants are grown for ornamental purposes, owing to their bright, shining fruits with a diverse range of colors [4]. Most abundantly, chili crops are grown in Pakistan, India, China, Ethiopia, Myanmar, Mexico, Vietnam, Turkey, Peru, Ghana, Bangladesh, Japan, Africa, and America (Table 1). As per 2019 world production statistics, the total global produce of chili pepper is 38 million tons [5]. China ranks first, producing over 18,978,027 tons of chili in 2019. In terms of nutritional standpoint, chili is considered to be one of the most nutritionally dense foods on earth, and it plays a vital role in alleviating human micronutrient deficiencies [6, 7]. Traditionalistically, it is harnessed in different systems of medicine to combat a wide variety of diseases and/or disorders due to the presence of therapeutically significant active constituents [8]. A total of 200 phytoconstituents have been identified from chilies [9]. Chili pepper’s extremely hot or burning sensation is due to capsaicinoids, a family of compounds consisting of acid amides of vanillylamine and a C8–C13branched-chain fatty acid [10]. Capsaicin and dihydrocapsaicin are the two prominent capsaicinoids present in chili peppers, accounting for over 90% of the total capsaicinoids [11]. Particularly, capsaicin has been at the center of intense research to elucidate the basis of its pharmacological properties and exploit its therapeutic potential [12, 13]. In recent times, this chemical substance has been employed as an analgesic in topical ointments, nasal sprays, and dermal patches to treat pain, typically in concentrations between 0.025 and 0.1%. It is also used to reduce the symptoms of peripheral neuropathy, such as postherpetic neuralgia caused by shingles [14]. Other capsaicinoids, such as nordihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin, are present in small amounts in chili peppers, accounting for less than 10% of the total capsaicinoids [15]. Therefore, this chapter aims to discuss the nutritional value, phytochemical profile, pharmacological properties, and health benefits of
Different types of chili plants.
Rank | Country | Production (tons) |
---|---|---|
1 | China | 18,978,027 |
2 | Mexico | 3,238,245 |
3 | Turkey | 2,625,669 |
4 | Indonesia | 2,588,633 |
5 | Spain | 1,402,380 |
6 | Egypt | 764.292 |
7 | Nigeria | 753.116 |
8 | Algeria | 675.168 |
9 | United States of America | 624.982 |
10 | Tunisia | 443.632 |
Chili peppers are a good source of dietary fiber, riboflavin, thiamin, folate, niacin, iron, protein, phosphorus, and copper. Aside from that, it also contains high amounts of vitamin A, vitamin C, vitamin K, vitamin E, vitamin B6, potassium, and manganese [16]. The nutritional composition of chili peppers per 100 g is listed in Table 2. Chili fruits are also rich in many phytochemicals such as carotenoids (lutein, β-carotene, β-cryptoxanthin, zeaxanthin, violaxanthin, and capsanthin), capsaicinoids (capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, homodihydrocapsaicin, and nonivamide), and flavonoids (quercetin, luteolin, kaempferol, catechin, epicatechin, rutin, apigenin, myricetin, and cyanidin) [17, 18]. The following Figure 3 shows the chemical structures of the various phytochemical constituents.
S. No. | Types of nutrient | Amount |
---|---|---|
1 | Water | 88.02 g |
2 | Energy | 40 kcal |
3 | Protein | 1.87 g |
4 | Fat | 0.44 g |
5 | Carbohydrate | 8.81 g |
6 | Fiber | 1.5 g |
7 | Sugars | 5.3 g |
Minerals | ||
8 | Calcium | 14 mg |
9 | Iron | 1.03 mg |
10 | Magnesium | 23 mg |
11 | Phosphorus | 43 mg |
12 | Potassium | 322 mg |
13 | Sodium | 9 mg |
14 | Zinc | 0.26 mg |
Vitamins | ||
15 | Vitamin C | 143.7 mg |
16 | Thiamin | 0.072 mg |
17 | Riboflavin | 0.086 mg |
18 | Niacin | 1.244 mg |
19 | Vitamin B-6 | 0.506 mg |
20 | Folate | 23 μg |
21 | Vitamin A | 48 μg |
22 | Vitamin E | 0.69 mg |
23 | Vitamin K | 14 μg |
Lipids | ||
24 | Fatty acids, total saturated | 0.042 g |
25 | Fatty acids, total monounsaturated | 0.024 g |
26 | Fatty acids, total polyunsaturated | 0.239 g |
Nutritional composition of chili pepper (per 100 g).
Chemical structures of various phytochemical constituents in chili pepper.
The mechanism behind the therapeutic potential of chili pepper has been apprised in several hefty pieces of literature. Chili is effective against a great number of ailments such as cancer, rheumatoid arthritis, bronchitis, macular degeneration, anemia, osteoporosis, coronary heart disease, diabetes, obesity, hypertension, sinus infection, migraine, neurological disorders, menopausal problems, and digestive complications [19, 20, 21, 22, 23, 24, 25]. Figure 4 displays the pharmacological activities of chili pepper. Herein, the immense potential of chili in battling severe illnesses, as well as the mechanisms associated with health-promoting actions, have been illustrated in detail.
Pharmacological activities of chili pepper.
Cancer is a group of diseases characterized by uncontrolled growth and the spread of abnormal cells. It is the world’s second leading cause of death, with a 10 million fatality rate annually [26]. A series of changes in the activities of cell cycle regulators are usually hooked up for cancer development and progression [27]. Generally, cancers are often named for the organ or cell type where the abnormal cells first form. Lung, prostate, colorectal, stomach, and liver cancer are the most prevalent types of cancer in men, while breast, colorectal, lung, cervical, and thyroid cancer are the most endemic among women [26]. Current chemotherapeutic drugs are enormously utilized to destroy cancer cells. Still, in addition to targeting the diseased cells, it also kills healthy blood cells, skin, stomach, hair follicles, bone marrow, etc. As a consequence of the undesirable properties and side effects of synthetic drugs, natural products have become increasingly popular over the past few decades. Capsaicin, the spicy ingredient of hot chili peppers, exhibits anti-neoplastic activity in a vast number of cancers like pancreatic cancer, colon cancer, liver cancer, lung cancer, prostate cancer, breast cancer, bladder cancer, and skin cancer [28, 29, 30, 31, 32, 33, 34, 35, 36]. The significant anticancer capacity of capsaicin targets multiple signaling pathways and cancer-associated genes in different phases of tumor development, including initiation, promotion, progression, and metastasis [37]. Table 3 shows that various
Cancer type | Dose or concentration/duration of application/ingestion | Effect/mechanism | Experimental model | References |
---|---|---|---|---|
Pancreatic cancer | 200 μM/L for 24 h | Endoplasmic reticulum stress (ERS) mediated apoptosis | [38] | |
150 μM/L for 24 h | ||||
5 mg/kg oral administration for 35 days | Suppresses tumor growth by inhibiting Trx and activating ASK1 | [39] | ||
Colon cancer | 200 and 300 μM for 24 h | Peroxisome proliferator-activated receptor ƴ (PAPR ƴ) mediated apoptotic cell death | [40] | |
10–400 μM for 24 h | G0/G1 cell cycle arrest and induce apoptosis | [41] | ||
1 and 3 mg/kg intraperitoneal administration for 30 days | Inhibition of tumor growth | [42] | ||
Liver cancer | 50 μM for 36 h | Inhibition of migration and invasion | [43] | |
50 μM for 3 h | Inhibition of adhesion | |||
Lung cancer | 50 μM for 72 h | Inhibition of cell proliferation through E2F pathway | [44] | |
10 mg/kg in an AIN-76A based diet | ||||
Prostate cancer | 1–100 μM for 24–72 h | Inhibition of PI3K/Akt/mTOR axe and modulates autophagy | [45] | |
5 mg/kg, 3 days a week, oral administration for 30 weeks | Inhibition of migration, invasive, neuroendocrine differentiation process, and upregulation of the tumor suppressor protein p27Kip1 | [46] | ||
Breast cancer | 200 μM for 72 h | Inhibition of cell growth via apoptosis and cell cycle arrest in the S phase | [47] | |
10 mg/kg, once in 3 days, intraperitoneal administration for 21 days | Inhibition of proliferation and induces apoptosis via down-regulating FBI-1 mediated NF-κB pathways (Ki-67, Bcl-2, Bax, caspase 3, and survivin proteins) | [48] | ||
Bladder cancer | 50–300 μM for 48 h | Suppresses cell proliferation, induces cell cycle arrest and ROS production through modulating FOXO3a-mediated pathways | [49] | |
20 mg/kg, every two days for four weeks, injected peritumoral area |
Anticancer effects of capsaicin on various cancers in
Pancreatic cancer, one of the most lethal malignancies, is the seventh leading cause of cancer-related fatality globally. This disorder is broken down into two forms: pancreatic adenocarcinoma (85%, with a very poor prognosis) and pancreatic neuroendocrine tumors [50]. In patients with advanced pancreatic cancer, the survival rate is less than one year. Numerous studies have explored the possibility of improving survival in pancreatic cancer with new therapies. Over the past few years, researchers have studied the effects of capsaicin on various pancreatic cancer cell lines, including BxPC-3, AsPC-1, PANC-1, SW1990, MiaPaCa-2, and L3.6pl. Based on the results of these studies, anti-proliferative activities of capsaicin are mainly attributed to the inhibition of oxidative stress and angiogenesis, cell cycle regulation, and apoptosis induction [38, 51, 52]. The first report on the involvement of endoplasmic reticulum stress (ERS) in the induction of apoptosis in PANC-1 and SW1990 cells using capsaicin was described by Lin et al. [38]. The authors demonstrated the potency of capsaicin on the mRNA expression of two key ERS markers (GRP78 and GADD153) in PANC-1 and SW1990 cells. According to real-time PCR analysis, capsaicin significantly increased the mRNA expression of GRP78 and GADD153 in a time and dose-dependent manner, suggesting ERS-mediated apoptosis and cell growth inhibition.
Globally, colon cancer is one of the most prevalent forms of cancer, posing a major public health threat. In 2020, approximately 1,148,515 people were diagnosed with colon cancer, and 576,858 people died from this disease worldwide [53]. The onset of colon cancer is associated with excessive cell proliferation and dysregulation of both cell-cycle progression and apoptosis. Additionally, “neoangiogenesis” plays an essential role in the development, growth, and metastasis of colon tumors [54]. In the majority of cases, colon tumors are only diagnosed in the later stages of the disease, because they do not manifest as pain-like symptoms. Over time, several strides have been made in researching and treating colon cancer. However, its survival rate has not significantly improved. The five-year survival rate is still less than 15% due to the available therapeutic agents showing strong adverse effects and poor effectiveness [55]. Recent research reported that capsaicin has cytotoxic effects on different human colorectal cancer cell lines, including colo 205 and RKO [42, 56]. In a 2004 study, Kim et al. presented salient findings regarding the capsaicin-induced apoptotic cell death by activating peroxisome proliferator-activated receptor ƴ (PAPR ƴ) in HT-29 human colon cancer cells [40]. In addition, the latest study has shown that capsaicin mediates cell cycle arrest and apoptosis in two different human colon cancer cells (HCT116 and LoVo) via stabilizing and activating p53 in a time-dependent manner [41].
Hepatocellular carcinoma is the most-encountered primary liver cancer in adults. Overall, the incidence rate of liver cancer is approximately four times higher in males than in females, and its pathogenesis is usually considered as an overlap of long-lasting processes, such as hepatic cytolysis, inflammation, liver regeneration, and fibrosis [57]. In hepatocellular carcinoma cell line HepG2, capsaicin-induced apoptosis with the involvement of intracellular Ca2+, ROS, Bcl-2 family, cytochrome c protein expression, and caspase-3 activity [58]. Co-treatment with capsaicin and sorafenib potentially inhibits cell proliferation by activating caspase-9, PARP, AMPK, acetyl CoA carboxylase phosphorylation in HepG2 and Huh-7 cells [59].
Lung cancer is the leading cause of mortality in both men and women, and it causes 1.8 million deaths annually. On the medical front, the prognosis of lung cancer is poor because it cannot produce noticeable signs and symptoms in the early stages. Being exposed to cigarette smoke/smoking is considered the most important factor involved in lung cancer development. Besides, environmental pollution and epigenetic alterations can also lead to lung cancer progression. This kind of cancer is broadly classified into two types: small cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). NSCLC is the predominant type of lung cancer, accounting for about 85% of cases, while SCLC is responsible for 15% of lung cancer cases [60]. Capsaicin exhibited its therapeutic efficiency in lung cancer treatment by means of inhibiting Hypoxia-inducible factor (HIF)-1α accumulation by suppressing mitochondrial respiration in human lung cancer cells (H1299, H23, A549, and H2009) [61]. Furthermore, the time-dependent antitumor effects of capsaicin on lung cancer were also described in an
Prostate cancer is the most common invasive malignancy among males. The incidence rate has increased in recent years in most regions of the world, perhaps due to improved detection methods with prostate-specific antigen (PSA) testing; however, the mortality rate has remained constant since the early 1900s. Androgen and androgen receptor (AR) play a critical role in the growth and maintenance of the prostate gland and the development of prostate tumors [63]. Prostate cancer may be connected with debilitating disease-related complications in an advanced stage, including painful bone metastases and urinary tract obstruction. microRNAs (miRNAs) are a class of small non-coding RNAs (ncRNAs) that regulate gene expression by repressing translation and have been proven to be implicated in the regulation of crucial processes, such as proliferation, differentiation, and apoptosis in various kinds of cancer [64]. Among the miRNAs, miR-449a functions as an important tumor suppressor in many types of tumors by targeting different genes. Recently, Zheng et al. found that capsaicin inhibits the proliferation of AR-positive prostate cancer cells (C4-2 and LNCaP) by inducing the restoration of miR-449a [65]. Additional convergent pieces of evidence have shown that the capsaicin combined with brassinin and docetaxel synergistically kills human prostate cancer cells (PC-3 and LNCaP) through metabolic regulator AMP-activated kinase and apoptosis [66, 67].
Breast cancer is the second most prevalent cancer worldwide and causes a high number of deaths among women every year. In the proliferation of breast cancer cells, NF-κB—the proinflammatory transcription factor plays a key role. It regulates more than 500 different genes and governs the expression of proteins engaged in cellular signaling pathways, leading to the development of malignancies and inflammation. Capsaicin displayed the ability to affect breast cancer cell proliferation by downregulating the FBI-1-Mediated NF-κB pathway [48]. Another target that acts on the proliferation of breast cancer cells is the human epidermal growth factor receptor-2 (HER-2), a tyrosine kinase (TK) receptor belonging to the EGFR family. A recent study by Thoennissen et al. showed capsaicin causes cell-cycle arrest and apoptosis in breast cancer cells (MCF-7, T47D, BT-474, SKBR-3, and MDA-MB231) via modulating the EGFR/HER-2 pathway [68].
Cyclin-dependent kinases (CDKs), a member of the serine/threonine-protein kinase family, can coordinate critical regulatory events during the cell cycle and transcription. Alterations in at least one CDK regulator or effector have been identified in almost all types of cancer. CDK8, as a member of the CDK family, serves a crucial role in gene transcription. Apart from this, phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathways also play an important role in many aspects of cell growth and survival under both physiological and pathological conditions. Dysregulation of this pathway has been observed a various transformed cells and cancer tumors. In addition, aberrant activation of the Wnt/β-catenin signaling pathway causes β-catenin accumulation in the nucleus and can induce breast cancer. However, Wu et al. demonstrated that capsaicin inhibited breast cancer cell viability, induced G2/M cell cycle arrest, reduced CDK8 expression levels, decreased the phosphorylation of PI3K and Akt, and downregulated Wnt and β catenin expression levels in MDA MB 231 cells [69].
Bladder cancer is a common malignancy affecting the genitourinary system. It is generally subdivided into two types: nonmuscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). About 30% of total patients are MIBC and have a high mortality rate due to distant metastases. Meanwhile, 70% of patients are NMIBC, which are likely to progress MIBC. Morphologically, bladder tumors can be divided into papillary, solid, and mixed types. However, the papillary type is predominant, especially in NMIBC [70]. A poor prognosis and resistance to chemotherapy are the two most important characteristics of this disease. Recently, Yang et al. reported capsaicin-induced cell death in human bladder cancer T24 cells through calcium entry-dependent ROS production and mitochondrial depolarization [71]. Likewise, Chen et al. also demonstrated capsaicin-induced cell cycle arrest by inhibiting cyclin-dependent-kinase in 5637 bladder carcinoma cells [72].
Microorganisms are liable for causing food spoilage and various foodborne illnesses every year. These illnesses can generate many ailments, ranging from stomach discomfort to spontaneous abortions in pregnant women, and can even lead to death in severe cases. Researchers have recently stated that some varieties of chili peppers and their active compounds exhibit significant antimicrobial properties, equivalent to some modern-day antibiotics [73, 74, 75, 76]. Especially, Goci et al. investigated the carbopol-based formulated capsaicin enhances the antibacterial and antifungal effects against
Diabetes mellitus is a chronic endocrine disease characterized by disorders in the metabolism of carbohydrates, lipids, and proteins due to a deficiency in insulin production by pancreatic beta cells and/or an increase in insulin resistance in peripheral tissues. Universally, this illness affects the majority of people in both developed and developing countries. Numerous synthetic drugs have been developed for the treatment, but a safe and effective paradigm is yet to be achieved. In terms of potential as a pharmacological alternative, chili has shown good antidiabetic effect because it contains α-amylase and α-glucosidase inhibitors, which are required for the degradation of polysaccharides and disaccharides. Especially, the species
Arthritis is an autoimmune disorder that causes pain, swelling, and stiffness in the joints. There are at least 100 types of arthritis, commonly known as connective tissue disorders, which can affect people of all ages, gender, and races. However, there is significant evidence to suggest that both the elderly and women are greatly affected. More than three decades ago, capsaicin was first shown to have protective effects in experimental arthritis [79]. Further, Inman et al. observed that capsaicin concomitantly administered with methylated bovine serum albumin (mBSA) into the rat knee markedly reduced the severity of arthritis in comparison with the contralateral inflamed knee treated with vehicle, supporting a protective role for capsaicin in reducing the severity of antigen-induced arthritis in felines [80]. According to the trend, capsaicin cream is used to reduce pain caused by many types of arthritis. Specifically, it works by decreasing a certain natural substance in the human body (substance P) that helps transmit pain signals to the brain.
The family of free radicals generated from the oxygen is referred to as reactive oxygen species (ROS), which cause damage to other molecules by extracting electrons from them in order to attain stability. ROS are various forms of activated oxygen which include free radicals such as superoxide anion radicals (O2−), hydroxyl radicals (OH−), non-free radicals (H2O2), and singlet oxygen [81]. The molecular basis of many diseases is known to involve oxidative stress caused by free radicals [82]. Recently progressive research has been directed at natural antioxidants. By using the DPPH free radical assay, Dubey et al. evaluated the antioxidant potential and free radical scavenging activities of some selective chili genotypes from the North East region of India in terms of inhibitory concentration (IC50), efficiency concentration (EC50), and anti-radical power (ARP) [83]. Likewise, Ayob et al. also determined the antioxidant activity of three varieties of Himalayan red chili (Kashmiri Local, Kupwari Local, and Shalimar Long) in North India by using DPPH radical scavenging activity, Hydroxyl radical scavenging activity, and Ferric reducing power, based on EC50 values [84].
Cardiovascular disease remains a leading cause of disability and premature death globally. The disease is mimicked by the narrowed lumen of arteries and reduced blood flow to the heart. According to a report presented at the American Heart Association’s Scientific Sessions 2020, regular intake of chili peppers could significantly reduce the risk of dying from cardiovascular diseases. Moreover, very recent striking findings of a pooled longitudinal analysis by Bonaccio et al. illustrated the cardiovascular benefits of
Neurodegenerative diseases such as Alzheimer’s disease are often characterized by multifactorial clinical features such as loss of memory function, protein aggregation, progressive loss of neurons, cognitive impairment, neuronal cell dysfunction, and/or death. Capsaicin is a vanilloid agonist known to activate the TRPV1, recently reported to be involved in neurodegeneration [90]. A study by Veldhuis et al. demonstrated that capsaicin and the vanilloid antagonist capsazepine, peripherally administered, have been shown to exhibit neuroprotection against ouabain-induced excitotoxicity in rats [91]. Moreover, in the latest evidence, Abdel-Salam et al. reported the effect of the TRPV1 agonist capsaicin on epileptic seizures, neuronal injury, and brain oxidative stress in a model of status epilepticus induced in the rat by intraperitoneal (i.p.) injections of pentylenetetrazole (PTZ). This study shows that 2 mg/kg of capsaicin decreased brain oxidative stress, the severity of seizures and neuronal injury, and its coadministration with phenytoin afforded neuronal protection [92].
The authors declare no conflict of interest.
The authors declare that the chapter’s content is for informational or educational purposes only and does not substitute professional medical advice or consultations with healthcare professionals.
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VR provides a 3D and dynamic view of structures and the ability of the user to interact with them. The recent technological advances in haptics, display systems, and motion detection allow the user to have a realistic and interactive experience, enabling VR to be ideal for training in hands-on procedures. Consequently, surgical and other interventional procedures are the main fields of application of VR. AR provides the ability of projecting virtual information and structures over physical objects, thus enhancing or altering the real environment. The integration of AR applications in the understanding of anatomical structures and physiological mechanisms seems to be beneficial. Studies have tried to demonstrate the validity and educational effect of many VR and AR applications, in many different areas, employed via various hardware platforms. Some of them even propose a curriculum that integrates these methods. This chapter provides a brief history of VR and AR in medicine, as well as the principles and standards of their function. Finally, the studies that show the effect of the implementation of these methods in different fields of medical training are summarized and presented.",book:{id:"6211",slug:"medical-and-surgical-education-past-present-and-future",title:"Medical and Surgical Education",fullTitle:"Medical and Surgical Education - Past, Present and Future"},signatures:"Panteleimon Pantelidis, Angeliki Chorti, Ioanna Papagiouvanni,\nGeorgios Paparoidamis, Christos Drosos, Thrasyvoulos\nPanagiotakopoulos, Georgios Lales and Michail Sideris",authors:[{id:"211650",title:"M.D.",name:"Panteleimon",middleName:null,surname:"Pantelidis",slug:"panteleimon-pantelidis",fullName:"Panteleimon Pantelidis"},{id:"211654",title:"Ms.",name:"Angeliki",middleName:null,surname:"Chorti",slug:"angeliki-chorti",fullName:"Angeliki Chorti"},{id:"220557",title:"Ms.",name:"Ioanna",middleName:null,surname:"Papagiouvanni",slug:"ioanna-papagiouvanni",fullName:"Ioanna Papagiouvanni"},{id:"220558",title:"Mr.",name:"Georgios",middleName:null,surname:"Paparoidamis",slug:"georgios-paparoidamis",fullName:"Georgios Paparoidamis"},{id:"220559",title:"Mr.",name:"Georgios",middleName:null,surname:"Lales",slug:"georgios-lales",fullName:"Georgios Lales"},{id:"220560",title:"Mr.",name:"Thrasyvoulos",middleName:null,surname:"Panagiotakopoulos",slug:"thrasyvoulos-panagiotakopoulos",fullName:"Thrasyvoulos Panagiotakopoulos"},{id:"220561",title:"Mr.",name:"Christos",middleName:null,surname:"Drosos",slug:"christos-drosos",fullName:"Christos Drosos"},{id:"220562",title:"Dr.",name:"Michail",middleName:null,surname:"Sideris",slug:"michail-sideris",fullName:"Michail Sideris"}]},{id:"50915",doi:"10.5772/63266",title:"Doped Bioactive Glass Materials in Bone Regeneration",slug:"doped-bioactive-glass-materials-in-bone-regeneration",totalDownloads:3480,totalCrossrefCites:13,totalDimensionsCites:33,abstract:"In the arena of orthopaedic surgery, autograft is considered to be the gold standard for correction of fracture repair or other bone pathologies. But, it has some limitations such as donor site morbidity and shortage of supply, which evolved the use of allograft that also has some disadvantages such as immunogenic response to the host, low osteogenicity as well as possibilities of disease transmission. Despite the benefits of autografts and allografts, the limitations of each have necessitated the pursuit of alternatives biomaterials that has the ability to initiate osteogenesis, and the graft should closely mimic the natural bone along with regeneration of fibroblasts. A variety of artificial materials such as demineralised bone matrix, coralline hydroxyapatite and calcium phosphate-based ceramics such as hydroxyapatite (HA), β-tricalcium phosphate (β-TCP) and bioactive glass have been used over the decades to fill bone defects almost without associated soft tissue development. Most of them were having only the properties of osteointegration and osteoconduction. Only bioactive glass possesses osteogenic property that stimulates proliferation and differentiation of osteoprogenitor cells and in some cases influencing the fibroblastic properties. But, this material has also some disadvantages such as short-term and low mechanical strength along with decreased fracture resistance; but, this was further minimised by ion doping that positively enhanced new bone formation. There are many metal ions such as magnesium (Mg), strontium (Sr), manganese (Mn), iron (Fe), zinc (Zn), silver (Ag) and some rare earths that have been doped successfully into bioactive glass to enhance their mechanical and biological properties. In some of the cases, mesoporous bioactive glass materials with or without such doping have also been employed (with homogeneous distribution of pores in the size ranging between 2 and 50 nm). These biomaterials can be served as scaffold for bone regeneration with adequate mechanical properties to restore bone defects and facilitate healing process by regeneration of soft tissues as well. This chapter encompasses the use of bioactive glass in bulk and mesoporous form with doped therapeutic ions, their role in bone tissue regeneration, use as delivery of growth factors as well as coating material for orthopaedic implants.",book:{id:"5164",slug:"advanced-techniques-in-bone-regeneration",title:"Advanced Techniques in Bone Regeneration",fullTitle:"Advanced Techniques in Bone Regeneration"},signatures:"Samit Kumar Nandi, Arnab Mahato, Biswanath Kundu and Prasenjit\nMukherjee",authors:[{id:"60514",title:"Dr.",name:"Samit",middleName:null,surname:"Nandi",slug:"samit-nandi",fullName:"Samit Nandi"}]},{id:"37120",doi:"10.5772/29607",title:"Trigeminocardiac Reflex in Neurosurgery - Current Knowledge and Prospects",slug:"the-trigeminocardiac-reflex-in-neurosurgery-current-knowledge-and-prospects",totalDownloads:3423,totalCrossrefCites:10,totalDimensionsCites:27,abstract:null,book:{id:"749",slug:"explicative-cases-of-controversial-issues-in-neurosurgery",title:"Explicative Cases of Controversial Issues in Neurosurgery",fullTitle:"Explicative Cases of Controversial Issues in Neurosurgery"},signatures:"Amr Abdulazim, Martin N. Stienen, Pooyan Sadr-Eshkevari, Nora Prochnow, Nora Sandu, Benham Bohluli and Bernhard Schaller",authors:[{id:"78171",title:"Prof.",name:"Bernhard",middleName:null,surname:"Schaller",slug:"bernhard-schaller",fullName:"Bernhard Schaller"},{id:"78525",title:"Mr.",name:"Amr",middleName:null,surname:"Abdulazim",slug:"amr-abdulazim",fullName:"Amr Abdulazim"},{id:"78530",title:"Dr",name:"Pooyan",middleName:null,surname:"Sadr-Eshkevari",slug:"pooyan-sadr-eshkevari",fullName:"Pooyan Sadr-Eshkevari"},{id:"126039",title:"Dr.",name:"Martin",middleName:"Nikolaus",surname:"Stienen",slug:"martin-stienen",fullName:"Martin Stienen"},{id:"126040",title:"Dr.",name:"Nora",middleName:null,surname:"Prochnow",slug:"nora-prochnow",fullName:"Nora Prochnow"},{id:"126041",title:"Dr.",name:"Benham",middleName:null,surname:"Bohluli",slug:"benham-bohluli",fullName:"Benham Bohluli"}]},{id:"26559",doi:"10.5772/28833",title:"Local Antibiotic Therapy in the Treatment of Bone and Soft Tissue Infections",slug:"local-antibiotic-therapy-in-the-treatment-of-bone-and-soft-tissue-infections",totalDownloads:6551,totalCrossrefCites:5,totalDimensionsCites:21,abstract:null,book:{id:"784",slug:"selected-topics-in-plastic-reconstructive-surgery",title:"Selected Topics in Plastic Reconstructive Surgery",fullTitle:"Selected Topics in Plastic Reconstructive Surgery"},signatures:"Stefanos Tsourvakas",authors:[{id:"75532",title:"Dr.",name:"Stefanos",middleName:null,surname:"Tsourvakas",slug:"stefanos-tsourvakas",fullName:"Stefanos Tsourvakas"}]}],mostDownloadedChaptersLast30Days:[{id:"65467",title:"Anesthesia Management for Large-Volume Liposuction",slug:"anesthesia-management-for-large-volume-liposuction",totalDownloads:5965,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The apparent easiness with which liposuction is performed favors that patients, young surgeons, and anesthesiologists without experience in this field ignore the many events that occur during this procedure. Liposuction is a procedure to improve the body contour and not a surgery to reduce weight, although recently people who have failed in their plans to lose weight look at liposuction as a means to contour their body figure. Tumescent liposuction of large volumes requires a meticulous selection of each patient; their preoperative evaluation and perioperative management are essential to obtain the expected results. The various techniques of general anesthesia are the most recommended and should be monitored in the usual way, as well as monitoring the total doses of infiltrated local anesthetics to avoid systemic toxicity. The management of intravenous fluids is controversial, but the current trend is the restricted use of hydrosaline solutions. The most feared complications are deep vein thrombosis, pulmonary thromboembolism, fat embolism, lung edema, hypothermia, infections and even death. The adherence to the management guidelines and prophylaxis of venous thrombosis/thromboembolism is mandatory.",book:{id:"6221",slug:"anesthesia-topics-for-plastic-and-reconstructive-surgery",title:"Anesthesia Topics for Plastic and Reconstructive Surgery",fullTitle:"Anesthesia Topics for Plastic and Reconstructive Surgery"},signatures:"Sergio Granados-Tinajero, Carlos Buenrostro-Vásquez, Cecilia\nCárdenas-Maytorena and Marcela Contreras-López",authors:[{id:"273532",title:"Dr.",name:"Sergio Octavio",middleName:null,surname:"Granados Tinajero",slug:"sergio-octavio-granados-tinajero",fullName:"Sergio Octavio Granados Tinajero"}]},{id:"42855",title:"Critical Care Issues After Major Hepatic Surgery",slug:"critical-care-issues-after-major-hepatic-surgery",totalDownloads:8909,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"3164",slug:"hepatic-surgery",title:"Hepatic Surgery",fullTitle:"Hepatic Surgery"},signatures:"Ashok Thorat and Wei-Chen Lee",authors:[{id:"52360",title:"Prof.",name:"Wei-Chen",middleName:null,surname:"Lee",slug:"wei-chen-lee",fullName:"Wei-Chen Lee"},{id:"157213",title:"Dr.",name:"Ashok",middleName:null,surname:"Thorat",slug:"ashok-thorat",fullName:"Ashok Thorat"}]},{id:"72175",title:"Fontan Operation: A Comprehensive Review",slug:"fontan-operation-a-comprehensive-review",totalDownloads:1252,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Since the first description of the Fontan operation in the early 1970s, a number of modifications have been introduced and currently staged, total cavopulmonary connection with fenestration has become the most commonly used multistage surgery in diverting the vena caval blood flow into the lungs. The existing ventricle, whether it is left or right, is utilized to supply systemic circuit. During Stage I, palliative surgery is performed, usually at presentation in the neonatal period/early infancy, on the basis of pathophysiology of the cardiac defect. During Stage II, a bidirectional Glenn procedure is undertaken in which the superior vena caval flow is diverted into the lungs at an approximate age of 6 months. During Stage IIIA, the blood flow from the inferior vena cava (IVC) is rerouted into the pulmonary arteries, typically by an extra-cardiac conduit along with a fenestration, generally around 2 years of age. During Stage IIIB, the fenestration is closed by transcatheter methodology 6–12 months after Stage IIIA. The evolution of Fontan concepts, the indications for Fontan surgery, and the results of old and current types of Fontan operation form the focus of this review.",book:{id:"9585",slug:"advances-in-complex-valvular-disease",title:"Advances in Complex Valvular Disease",fullTitle:"Advances in Complex Valvular Disease"},signatures:"P. Syamasundar Rao",authors:[{id:"68531",title:"Dr.",name:"P. Syamasundar",middleName:null,surname:"Rao",slug:"p.-syamasundar-rao",fullName:"P. Syamasundar Rao"}]},{id:"45712",title:"Serdev Sutures® in Middle Face",slug:"serdev-sutures-in-middle-face",totalDownloads:4919,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"2989",slug:"miniinvasive-face-and-body-lifts-closed-suture-lifts-or-barbed-thread-lifts",title:"Miniinvasive Face and Body Lifts",fullTitle:"Miniinvasive Face and Body Lifts - Closed Suture Lifts or Barbed Thread Lifts"},signatures:"Nikolay Serdev",authors:[{id:"32585",title:"Dr.",name:"Nikolay",middleName:null,surname:"Serdev",slug:"nikolay-serdev",fullName:"Nikolay Serdev"}]},{id:"55812",title:"Postural Restoration: A Tri-Planar Asymmetrical Framework for Understanding, Assessing, and Treating Scoliosis and Other Spinal Dysfunctions",slug:"postural-restoration-a-tri-planar-asymmetrical-framework-for-understanding-assessing-and-treating-sc",totalDownloads:7646,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Current medical practice does not recognize the influence of innate, physiological, human asymmetry on scoliosis and other postural disorders. Interventions meant to correct these conditions are commonly based on symmetrical models of appearance and do not take into account asymmetric organ weight distribution, asymmetries of respiratory mechanics, and dominant movement patterns that are reinforced in daily functional activities. A model of innate, human asymmetry derived from the theoretical framework of the Postural Restoration Institute® (PRI) explicitly describes the physiological, biomechanical, and respiratory components of human asymmetry. This model is important because it gives an accurate baseline for understanding predisposing factors for the development of postural disorders, which, without intervention, will likely progress to structural dysfunction. Clinical tests to evaluate tri-planar musculoskeletal relationships and function, developed by PRI, are based on this asymmetric model. These tests are valuable for assessing patient’s status in the context of human asymmetry and in guiding appropriate exercise prescription and progression. Balancing musculoskeletal asymmetry is the aim of PRI treatment. Restoration of relative balance decreases pain, restores improved alignment, and strengthens appropriate muscle function. It can also halt the progression of dysfunction and improve respiration, quality of life, and appearance. PRI’s extensive body of targeted exercise progressions are highly effective due to their basis in the tri-planar asymmetric human model.",book:{id:"5816",slug:"innovations-in-spinal-deformities-and-postural-disorders",title:"Innovations in Spinal Deformities and Postural Disorders",fullTitle:"Innovations in Spinal Deformities and Postural Disorders"},signatures:"Susan Henning, Lisa C. Mangino and Jean Massé",authors:[{id:"204825",title:"Dr.",name:"Susan",middleName:null,surname:"Henning",slug:"susan-henning",fullName:"Susan Henning"},{id:"206242",title:"Dr.",name:"Lisa C",middleName:null,surname:"Mangino",slug:"lisa-c-mangino",fullName:"Lisa C Mangino"},{id:"206245",title:"Dr.",name:"Jean",middleName:null,surname:"Massé",slug:"jean-masse",fullName:"Jean Massé"}]}],onlineFirstChaptersFilter:{topicId:"202",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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\r\n\tThis series will provide a comprehensive overview of recent research trends in business and management, economics, and marketing. Topics will include asset liability management, financial consequences of the financial crisis and covid-19, financial accounting, mergers and acquisitions, management accounting, SMEs, financial markets, corporate finance and governance, managerial technology and innovation, resource management and sustainable development, social entrepreneurship, corporate responsibility, ethics and accountability, microeconomics, labour economics, macroeconomics, public economics, financial economics, econometrics, direct marketing, creative marketing, internet marketing, market planning and forecasting, brand management, market segmentation and targeting and other topics under business and management. This book series will focus on various aspects of business and management whose in-depth understanding is critical for business and company management to function effectively during this uncertain time of financial crisis, Covid-19 pandemic, and military activity in Europe.
",coverUrl:"https://cdn.intechopen.com/series/covers/22.jpg",latestPublicationDate:"June 27th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"356540",title:"Prof.",name:"Taufiq",middleName:null,surname:"Choudhry",slug:"taufiq-choudhry",fullName:"Taufiq Choudhry",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000036X2hvQAC/Profile_Picture_2022-03-14T08:58:03.jpg",biography:"Prof. Choudhry holds a BSc degree in Economics from the University of Iowa, as well as a Masters and Ph.D. in Applied Economics from Clemson University, USA. In January 2006, he became a Professor of Finance at the University of Southampton Business School. He was previously a Professor of Finance at the University of Bradford Management School. He has over 80 articles published in international finance and economics journals. His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. She has over 160 Scientific Publications in International Journals and Conferences and she is the author of 5 books on Innovation and Decision Making in Industrial Applications and Engineering.",institutionString:null,institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",isOpenForSubmission:!0,editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",isOpenForSubmission:!0,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:"Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the 'new normal'. Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. 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She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!0,editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. Current research interests include trophic flows across ecosystems; watershed impacts of land-use change on biodiversity and ecosystem functioning; ecological civilization and water resource management; urban ecology and urban/rural sustainable development.",institutionString:null,institution:{name:"Soochow University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",isOpenForSubmission:!0,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. 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Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. 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