IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n
"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n
"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\n
In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\n
Feel free to share this news on social media and help us mark this memorable moment!
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n
"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n
"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\n
In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\n
Feel free to share this news on social media and help us mark this memorable moment!
\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"869",leadTitle:null,fullTitle:"Olive Oil - Constituents, Quality, Health Properties and Bioconversions",title:"Olive Oil",subtitle:"Constituents, Quality, Health Properties and Bioconversions",reviewType:"peer-reviewed",abstract:"The health-promoting effects attributed to olive oil, and the development of the olive oil industry have intensified the quest for new information, stimulating wide areas of research. This book is a source of recently accumulated information. It covers a broad range of topics from chemistry, technology, and quality assessment, to bioavailability and function of important molecules, recovery of bioactive compounds, preparation of olive oil-based functional products, and identification of novel pharmacological targets for the prevention and treatment of certain diseases.",isbn:null,printIsbn:"978-953-307-921-9",pdfIsbn:"978-953-51-4368-0",doi:"10.5772/1378",price:159,priceEur:175,priceUsd:205,slug:"olive-oil-constituents-quality-health-properties-and-bioconversions",numberOfPages:524,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"b26e27a335ddfd64f9583593dbd8ceb5",bookSignature:"Boskou Dimitrios",publishedDate:"February 1st 2012",coverURL:"https://cdn.intechopen.com/books/images_new/869.jpg",numberOfDownloads:143552,numberOfWosCitations:256,numberOfCrossrefCitations:66,numberOfCrossrefCitationsByBook:5,numberOfDimensionsCitations:280,numberOfDimensionsCitationsByBook:17,hasAltmetrics:1,numberOfTotalCitations:602,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 22nd 2011",dateEndSecondStepPublish:"March 22nd 2011",dateEndThirdStepPublish:"July 27th 2011",dateEndFourthStepPublish:"August 26th 2011",dateEndFifthStepPublish:"December 24th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8,9",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"77212",title:"Dr.",name:"Dimitrios",middleName:null,surname:"Boskou",slug:"dimitrios-boskou",fullName:"Dimitrios Boskou",profilePictureURL:"https://mts.intechopen.com/storage/users/77212/images/3142_n.jpg",biography:"Dimitrios Boskou received his diploma in chemistry from the School of Chemistry, Aristotle University of Thessaloniki, Hellas; his Philosophy Doctor degree from the University of London, UK; and his degree of Doctor of Science from the School of Chemistry, Aristotle University of Thessaloniki, Hellas. He served as an assistant, lecturer, assistant professor, associate professor, professor and head of the Laboratory of Food Chemistry and Technology, School of Chemistry, Aristotle University of Thessaloniki (1970–2006). From 1986 to 1998, he was a member of the IUPAC Commission on Oils, Fats, and Derivatives. In the years 1995–2005, he served as a member of the Supreme Chemical Council, Athens. From 1995 to 2012, he was a member of the Scientific Committee for Food of the European Commission and a member and expert of the Food Additives Panel of the European Food Safety Authority. His achievements are: over 90 published papers and reviews; author and editor of 8 books; author of 22 chapters in books related to major and minor constituents of fats, natural antioxidants, olive oil and frying of food; and contributor to international scientific encyclopedias and the Lexicon of Lipid Nutrition, a joint IUPAC/IUNS work.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"2",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"327",title:"Food Safety",slug:"food-safety"}],chapters:[{id:"27024",title:"Volatile and Non-Volatile Compounds of Single Cultivar Virgin Olive Oils Produced in Italy and Tunisia with Regard to Different Extraction Systems and Storage Conditions",doi:"10.5772/28699",slug:"volatile-and-non-volatile-compounds-of-single-cultivar-virgin-olive-oils-produced-in-italy-and-tunis",totalDownloads:3119,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:null,signatures:"Cinzia Benincasa, Kaouther Ben Hassine,Naziha Grati Kammoun and Enzo Perri",downloadPdfUrl:"/chapter/pdf-download/27024",previewPdfUrl:"/chapter/pdf-preview/27024",authors:[{id:"75035",title:"Dr.",name:"Enzo",surname:"Perri",slug:"enzo-perri",fullName:"Enzo Perri"},{id:"83499",title:"Dr.",name:"Cinzia",surname:"Benincasa",slug:"cinzia-benincasa",fullName:"Cinzia Benincasa"},{id:"124199",title:"Dr.",name:"Kaouther",surname:"Ben Hassine",slug:"kaouther-ben-hassine",fullName:"Kaouther Ben Hassine"},{id:"124200",title:"Dr.",name:"Naziha Grati",surname:"Kammoun",slug:"naziha-grati-kammoun",fullName:"Naziha Grati Kammoun"}],corrections:null},{id:"27025",title:"Olive Oil Composition: Volatile Compounds",doi:"10.5772/28512",slug:"oil-composition-volatiles",totalDownloads:6988,totalCrossrefCites:2,totalDimensionsCites:20,hasAltmetrics:0,abstract:null,signatures:"Marco D.R. 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\r\n\tThe members of the Enterobacteria are prevalent and involved in different types of infections (nosocomial, urinary tract infections, respiratory infections, gastroenteritis, food poisoining, different outbreaks, etc.), and they need to be reviewed after a period of time as different variants and species evolve and cause different infections that need to be studied thoroughly.
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1. Introduction
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The fermentation industry has a long history since human ancestor occasionally produced alcohol, yogurt, and pickled food. Most of these fermentation products are related to the pathways of glycolysis and TCA cycle, which required microaerobic or anaerobic conditions to avoid the desired products being oxidized by oxygen.
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Precisely controlling microaerobic or anaerobic states is a challenge when using a general dissolved oxygen electrode because of the detection limit of the probe. Therefore, the measurement of redox potential (aka oxidoreduction potential, ORP) is considered as an ideal alternative approach because of its rapid response and high sensitivity to oxidation reaction.
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What’s more, redox potential also correlates to metabolic network, involving the genes, proteins, and metabolites. Since maintaining intracellular redox potential balance is a basic demand of cells, either intracellular or intercellular redox potential control could be the effective methods to redistribute metabolic flux toward targeted products. This idea has been applied to make a broad range of fermented products.
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In this chapter, the basic principle of redox potential and its intracellular influence on genes, proteins, and metabolites are reviewed. Furthermore, redox potential control by metabolic modification and process engineering on the various metabolite fermentations are illustrated, specifically for ethanol production as an example.
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2. Basic theory of redox potential
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Chemically, the oxidation–reduction potential (aka ORP or redox potential) is defined as the tendency for a molecule to acquire electrons. It involves two components known as redox pair during the electron transfer process, of which the oxidizing one (Ox) attracts electrons and then becomes the reducing one (Red). This relationship is illustrated below:
Ox+ne-=RedE1
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Electrons are exchanged during a redox reaction, in which a pair of oxidation reaction and reduction reaction must be involved. As an illustration, when oxidizing iodide by ferric iron to form iodine, the iodine ion loses two electrons to from iodine (known as oxidation), concurrently ferric ion receives the same amount electrons to form ferrous ion (known as reduction). As a result, a complete redox reaction is established.
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Oxidation: 2I− = I2 + 2e−
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Reduction: 2Fe3+ + 2e− = 2Fe2+
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Redox reaction: 2Fe3+ + 2I− = 2Fe2+ + I2
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In an aqueous system, the redox potential is related to the capacity of releasing or accepting electrons from all redox reactions. Similar to pH where it indicates the availability of hydrogen ions, the overall redox potential portrays a relative state of gaining or losing electrons. However, the net changes of redox potential are caused by all oxidizing and reducing agents in the aqueous system, not just alkalis and acids that determine pH values.
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In 1889, Walter Hermann Nernst (1864–1941; Nobel Prize: 1920) developed an equation to interpret the theory of galvanic cells by taking the changes of Gibbs free energy (ΔG) and the mass ratio into account. The Gibbs free energy is a thermodynamic potential, a reduction of G is a necessary condition for the spontaneity of processes at constant pressure and temperature. The chemical reaction can occur only if the ΔG is negative.
Eh=E0+RTnFInOxRedE2
∆G=-nF∆Eh3E3
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E0 is the standard redox potential of a system obtained at standard state. Every chemical pair has its own intrinsic redox potential. The greater affinity for electrons, the higher standard redox potential could be. Generally, NAD+/NADH, NADP+/NADPH, GSSG/2GSH, ubiquinone (ox/red), and oxygen/water are some of the most common chemical pairs in cells, whose E0 were −320, −315, −240, +100, and +820 mV, respectively.
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R is the universal gas constant; T is the absolute temperature; F, Faraday constant (96,485 C/mol), is the number of coulombs per mole of electrons, and n is the number of transferred electrons. The equation implies the concentration of species and temperature plays the key roles for redox potential change.
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For instance, the reaction of NADH oxidized by oxygen is the final step of electron transport chain during aerobic respiration in mitochondrion. Usually, the reaction involves two redox pairs, just like oxygen/water (+820 mV) and NAD+/NADH (320 mV), thus ΔEh = 820 mV – (−320 mV) = 1140 mV, ΔG = −125 kJ/mol, which indicates that this process occurs spontaneously due to the negative value of ΔG.
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Although the Nernst equation has been broadly used in biological systems because of the involvement of electron transfer chain, one fact should be noticed that the redox potential measured by a platinum electrode is not a thermodynamically calculated value. It measures the redox state in an aqueous system as voltages. Although a living biosystem centers on cell growth and metabolism, it is an open system where the intracellular equilibrium state is not always established. Nevertheless, the significance of redox potential on functioning biological systems was predicted nearly one century ago by two prestigious British scientists at the University of Cambridge [1]. Many scientists, since then, have successfully explored various correlations between extracellular redox potential measured by an electrode and intracellular biological properties.
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3. Extracellular redox potential
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The extracellular redox potential is different from intracellular redox state due to cytomembrane separation and cell redox homeostasis. Environmental factors are critical to indirectly shift the cellular redox potential. Based on Nernst Equation, the redox potential is simply determined by the ratio of oxidative state to reductive state at a fixed temperature, which is always a constant parameter in most biological processes. Figure 1 illustrates three general approaches to control extracellular redox potential in biological devices.
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Figure 1.
Approaches to control extracellular redox potential. (A) energy input, (B) redox reagents, and (C) gas sparging.
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3.1. Control extracellular redox potential by energy input
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Bioelectrical reactors (BERs), equipped with anodic and cathodic electrodes, were developed to regulate extracellular redox state in the medium through an external power source. It was used to replace chemical electron donor and acceptor in biosystem. BERs control redox potential at a certain level as easy as tuning a radio. It has been applied to microorganism cultivation and metabolites production [2]. Nevertheless, BERs have been implemented in a laboratory setting or for the production of high-value products in order to compensate for its complicated equipment requirement and extra electrical energy consumption.
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3.2. Control extracellular redox potential by redox reagents
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Numerous chemicals with higher or lower standard redox potential than common metabolic components are supplemented into fermentation broth in order to alter environmental redox potential. Some commonly used reductants and oxidants to control extracellular redox potential include FeCl3, Na2S, potassium ferricyanide, dithiothreitol, cysteine, methyl viologen, neutral red, H2O2, and even directly NADH and NAD+ as additives. Unlike BERs requiring the design of a specific reactor, supplementing redox reagents can be employed in any type of bioreactor. However, the disadvantages are obvious: (a) extra chemicals added in media potentially interfere with intended bioprocessing and (b) some chemicals are too costly for industrial fermentation.
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Those problems could be solved using substrates with different reducing degree. Girbal and Soucaille [3] used mixed substrates (glucose, glycerol, and pyruvate) to interfere with the intracellular NADH/NAD+ ratio in Clostridium acetobutylicum. Snoep et al. [4] chose some energy source substrates, such as mannitol, glucose, and pyruvate, to govern cellular redox potential in Enterococcus faecalis.
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3.3. Control extracellular redox potential by gas sparging
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Oxygen and nitrogen are commonly used in aerobic and anaerobic fermentation, respectively. Thus, sparging pure or mixed gases into fermentation broth is one of the desired approaches to avoid unwanted reactions caused by redox salts. Generally speaking, oxygen elevates redox potential and hydrogen depresses it, whereas nitrogen and helium as inert gases remove dissolved oxygen or hydrogen from the medium. Furthermore, by adjusting the ratio of mixed gases, a different redox potential level can be maintained. Carbon monoxide and SO2 were also utilized to reduce the redox potential sometimes [5]. However, aerating a fermenter during fermentation is considered cost-effective only when air is used. As a mix of nitrogen, hydrogen and helium were applied to regulate redox potential in the above settings, these methods become too luxurious for industrial applications.
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3.4. Extracellular redox potential and dissolved oxygen
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Controlling the level of dissolved oxygen in a fermenter is essential for microorganisms to propagate under optimum physiological condition, not only because oxygen is involved in maintaining cell membrane integrity and function by synthesizing unsaturated fatty acid and sterol, but also for keeping metabolic flux channeling toward the production of desired products.
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A number of bioreactions toward the syntheses of intended metabolites requires maintaining dissolved oxygen at a proper level. For most microaerobic and anaerobic fermentations, conventional oxygen probe has trouble in distinguishing trace level dissolved oxygen from background noise, and its response time is not sufficient for the purpose of regulating dissolved oxygen level. Even for aerobic fermentation, redox potential still offers much more details about gaseous conditions than that collected from dissolved oxygen measurement [6]. The standard redox potential for the O2/H2O pair has the highest value among typical metabolites related to microbial metabolism during fermentation. If electrons were transferred to acceptors, oxygen must be the preferable choice even though its concentration is lower than other metabolites. Therefore, redox potential is much more sensitive in monitoring the presence of a trace amount of dissolved oxygen under microaerobic and anaerobic conditions.
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4. Intracellular redox potential
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Currently, advanced technologies, such as a nanosensor that can embed into individual cells, have been developed to measure intracellular redox potential directly for in-depth understanding on intracellular redox balance and its impact on cell physiology and metabolism. However, the indirect approaches, such as the measurement of NAD(P)H pools, NAD(P)+/NAD(P)H, GSH/GSSG, and the total oxidization power, are still commonly adopted to monitor the distribution of intracellular redox potential.
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4.1. Universal redox pairs in a cell
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A conjugate pair that constitutes a complete redox reaction is the fundamental of metabolic network in a cell. Many metabolic functions are realized through keeping intracellular redox balance with the main redox pairs, such as glutathione (GSH)/glutathione disulfide (GSSG), thioredoxin (TrxSS/Trx(SH)2), nicotinamide adenine dinucleotide (NAD), and nicotinamide adenine dinucleotide phosphatase (NADP). These redox systems, such as NADP+/NADPH, GSSG/2GSH, and TrxSS/Trx(SH)2, are not isolated systems. Both the Trx and GSH systems use NADPH as a source of reducing equivalents; thus, they are thermodynamically connected to each other. The role of NAD(P)+/NAD(P)H in redox reaction is illustrated in Figure 2.
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Figure 2.
The structure (A) and function (B) of NAD(P)H.
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Both glutathione (GSH) and thioredoxin are important reducing agents in all organisms, involved in cell oxidative stress response where they play an antioxidant role. Glutathione is a tripeptide (glutamine, cysteine, and glycine) that prevents damage to cellular components caused by reactive oxygen species such as free radicals and peroxides, lipid peroxides, and heavy metals. Thioredoxin is another class of small redox proteins with thiol system in the cell, which appears in many crucial biological processes, including redox signaling.
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The coenzymes are essential electron carriers in cellular redox reactions with the oxidized form NAD(P)+ and the reduced form NAD(P)H. The reduction reaction requires an input of energy and the oxidation reaction is exergonic. During carbohydrate metabolism, NADH plays as a notable reducing substance in catabolism, whereas NADPH, the other reducing component connected to anabolism, favors formation of amino acids, fatty acids, and nucleic acids. There are 129 enzymes that need NAD+ as cofactor in order to serve 931 redox reaction and 108 enzymes that require the involvement of NADP+ as cofactor in order to catalyze 1099 redox reaction (KEGG, 2016-3).
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4.2. Redox effect across the membrane
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Cytosol is isolated from the extracellular environment by a selectively permeable cytomembrane, which not only prevents the main redox pair escaping from the plasma freely but also conditionally allows the external redox chemicals to enter into the cytoplasm. As shown in Figure 3, chemicals with different reduction degrees, such as dithiothreitol (DDT), diamine, hydrogen peroxide, and oxygen, can unrestrictedly cross the membrane bilayer, causing the changes to the intracellular redox potential. However, most of these chemicals are prohibited to across the membrane. In another scenario, membrane proteins, such as oxidoreductase, involved in electron transport will respond and change the extracellular redox potential. For example, ferric reductase assists ferrous iron transport across the cell membrane [7]. Hydrogenase facilitates electron flow through the membrane with the conversion of NADH and NAD+ [8]. A low redox potential level results in the changes of thiol and disulfide balance on membrane proteins, making the membrane more permeable to protons [9]. A thiol-rich membrane protein transduces external GSH reducing power across the erythrocyte membrane, which can be explained as a thiol/disulfide exchange mechanism [10].
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Figure 3.
Intracellular redox response to extracellular redox potential and effects of redox potential on cellular metabolism and stress response.
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4.3. Effects of redox potential on a cell
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The influences of redox potential on enzymes activity have also been reported. Almost all enzymes related to oxidation–reduction reaction are redox potential sensitive, such as alcohol dehydrogenase, D-glyceraldehyde-3-phosphate dehydrogenase, quinone reductase (involved in quinone detoxification), NADH diphosphatase (involved in peroxisomal function), ubiquinone oxidoreductase (catalyzing the oxidation of NADH in the respiratory chain or in cytoplasm), mitochondrial NADH kinase (response to oxidative stress), and so on. The above-mentioned proteins have been investigated in Saccharomyces cerevisiae in the past decades. Numerous proteins contain sulfhydryl groups (PSH) due to their cysteine content. In fact, the concentration of PSH groups in cells and tissues is much greater than that of GSH. These groups can be present as thiols (-SH), disulfides (PS-SP), or mixed disulfides; Hsp33 as a possible chaperone and cysteine protease in heat shock protein families is regulated by redox potential, whose conformation changes from reduced state to oxidized state with the exposure of hydrophobic surface [11]. Being a key regulator of glutathione and, in turn, of redox potential, the identification of GSTp as, a JNK regulator, provides an important link between cellular redox potential and the regulation of stress kinase activities [12].
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Gene expression is controlled by redox states as well. It has been reported that overexpressing genes related to redox process in Escherichia coli resulted in the decrease of NADH/NAD+ ratio, which improve the cell growth profiles, because sufficient NAD+ is required to oxidize carbohydrate substrate during cell growth [13]. GPD2 encodes NAD-dependent glycerol 3-phosphate dehydrogenase, the key enzyme of glycerol synthesis, and is essential for cell survival under osmotic and low redox potential conditions. Unlike its homologous gene GPD1 controlled by high osmolality glycerol response pathway, GPD2 is regulated under anoxic conditions or, more accurately, oxygen-independent reducing environment [14]. YAP1, a transcription factor for sensing the high redox state (e.g. H2O2), usually exists in the cytoplasm but is transferred into nucleus to activate the transcription of antioxidant genes SOD1, TWF, TRX2, GLR1, and GSH1, when Yap1p C-terminal region with three conserved cysteine residues is oxidized in response to oxidative stress [15]. A redox sensing protein (RSP) binds transcriptional regulation regions located upstream from adhA, adhB, and adhE as a transcriptional repressor. The structure of RSP was changed from α-helix to β-sheet rich conformation when redox potential declined by adding NADH. Meanwhile, the repression of an alcohol dehydrogenase transcription caused by RSP was reversed [16]. Thioredoxin reduces cysteine moieties in the DNA-binding sites of several transcription factors and is therefore important in gene expression [17].
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External redox potential correlates the net balance of intracellular reducing equivalents and the changes in the cellular redox environment can alter signal transduction, DNA and RNA synthesis, protein synthesis, enzyme activation, and even regulation of the cell cycle. Thus, monitoring and controlling environmental redox potential helps to elucidate cellular physiology and intracellular metabolic interaction.
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5. Redox potential and metabolic flux
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Strategies to control intracellular redox potential can be developed by altering intracellular redox potential pools, consequently resulting in redistribution of metabolic profiles. However, cells have a series of built-in mechanisms to adjust their own intercellular redox balance by cofactor regeneration through the oxidoreductase-harboring genes, including mitochondrial alternative oxidase (AOX), formate dehydrogenase (FDH), cytoplasmic H2O-forming NADH oxidase (NOX), and mitochondrial NADH kinase (POS5). Therefore, modification of these genes is a promising strategy to “design” a robust strain subjected to redox regulation through extracellular manipulation, although such an alternation may result in unexpected outcomes.
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5.1. Alternative oxidase
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The alternative oxidase (AOX, EC: 1.10.3.11), also named ubiquinol oxidase, forms a part of the electron transport chain in mitochondria. The function of this oxidase is believed to dissipate excess reducing power. The reaction catalyzed by AOX oxidase (ubiquinol oxidase) is shown in Reaction (4).
ubiquinone+5H++NADH=ubiquinol+4H++NAD+E4
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When a cell subjected to increasing glycolytic fluxes under aerobic conditions, a decrease in respiratory capacity is caused by the presence of excess glucose that repressed respiratory pathways. Introducing a heterologous alternative oxidase into S. cerevisiae, increased metabolic flux toward respiration and reduced aerobic ethanol formation [18]. In other investigation, the introduction of AOX pathway improved reactive oxygen species and pyruvate levels simultaneously under stressful conditions, such as suboptimal temperature and hyperosmotic pressure [19].
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5.2. Formate dehydrogenase
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Formate dehydrogenases (FDH, EC: 1.2.1.2) are a set of enzymes that catalyze the oxidation of formate to carbon dioxide (see Reaction 6), donating electrons to a second substrate, such as NAD+ or cytochrome. NAD+-dependent formate dehydrogenases are important in methylotrophic yeast and bacteria and are vital in the catabolism of C1 compounds, such as methanol.
formate+NAD+=CO2+NADHE5
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As the FDH gene from Candida boidinii was introduced into Paenibacillus polymyxa, highly expressed exogenous FDH increased NADH/NAD+ and the titers of NADH-dependent products such as lactic acid and ethanol, while resulting in significantly decreased acetoin and formic acid [20]. In addition, the increased capacity of a FDH gene in Bacillus subtilis efficiently enhanced the production of 2,3-butanediol and decreased the formation of acetoin through increasing the availability of NADH [21]. In another case, an engineered strain for the conversion of D-fructose to allitol was developed by constructing a multienzyme coupling pathway and cofactor recycling system in E. coli. FDH gene was used to support the cofactor recycling system for the availability of NADH [22].
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5.3. NADH oxidase
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NADH oxidase (NOX, EC: 1.6.3.4) is a membrane-associated enzyme that catalyzes the production of superoxide, a reactive free radical, by transferring one electron from NADH to oxygen as the electron acceptor (see Reaction 7). It is considered one of the major sources of producing superoxide anions in humans as well as bacteria, subsequently used in oxygen-dependent killing mechanisms for invading pathogens.
H++NADH+O2=H2O+NAD+E6
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Glycerol is a main by-product in the 2,3-butanediol metabolic pathways. To minimize glycerol accumulation by an engineered S. cerevisiae, the Lactococcus lactis NOX gene was inserted and expressed, resulting in substantial decreases in intracellular NADH/NAD+ ratio. As a result, the carbon flux was redistributed from glycerol to 2,3-butanediol [23]. NADH oxidase was also expressed with l-arabinitol dehydrogenase in E. coli to efficiently produce l-xylulose. Thus, the efficiency above 96% for the conversion of l-arabinitol into l-xylulose was achieved under optimized conditions [24].
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5.4. NADH kinase
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NADH kinase (like POS5, EC: 2.7.1.86) catalyzes the replacement reaction with two substrates ATP and NADH and two products ADP and NADPH (see Reaction 8). It provides a key source of the important cellular antioxidant NADPH.
ATP+NADH=ADP+H++NADPHE7
\n
NADPH is a key cofactor for carotenoid biosynthesis. Corynebacterium glutamicum was always used for the production of amino acids, such as L-isoleucine. By implementing NADPH-supplying strategies based on NAD kinase (PpnK), NADH kinase, glucose-6-phosphate dehydrogenase (Zwf), and PpnK coupling with Zwf, the expression of all genes increased both the intracellular NADPH concentration and the L-isoleucine production [25]. Researchers constructed the NADPH regenerators of heterologous NADH kinase to increase the availability of NADPH and resulted in a superior S-adenosylmethionine production in E. coli without requiring L-methionine addition [26]. When a S. cerevisiae strain-producing carotenoid was constructed by overexpressing glucose-6-phosphate dehydrogenase and NADH kinase individually, the final product β-carotene yield increased by 18.8% and 65.6%, respectively. Thus, NADPH supply improved by overexpression of NADH kinase is more important than glucose-6-phosphate dehydrogenase [27].
\n
\n
\n
\n
6. Application of redox potential to fermentation processes
\n
Controlling redox potential at a desired level alters the intracellular metabolic flow in order to favor the formation of desired product(s). Many researches have been conducted in this regard with a large number of examples for enhanced production of metabolites under redox potential–controlled conditions. Most studied metabolites using redox potential–controlled approaches are hydrogen, pyruvate, 1,3-propanediol, butanol, and 2,3-butanediol, and the following metabolites are reviewed but provided with references: acetoin [28], succinic acid [29], xylitol [30], and so on.
\n
\n
6.1. Hydrogen
\n
Hydrogen, as a clean and high-combustion energy in widespread areas, can be generated by fermentative anaerobes. Hydrogen production from anaerobic fermentation by bacteria demands reducing level because the standard redox potential of H2/H+ is low. Zhang et al. [8] showed that the addition of NAD+ during hydrogen fermentation by Enterobacter aerogenes resulted in the increase of overall hydrogen. Nakashimada et al. [31] investigated E. aerogenes for its hydrogen production under different intracellular redox state through the utilization of different substrates bearing various reduction degrees. Low redox potential accelerated the NAD(P)H-dependent hydrogenase activity in membrane and favors high H2 evolution capability. Ren et al. [32] assessed H2 production during butyric acid fermentation, propionic acid fermentation, and ethanol fermentation by controlling redox potential and pH simultaneously. Besides, the NAD+ synthetase encoded by nadE gene was homologously overexpressed in E. aerogenes to decrease the NADH/NAD+ ratio and thus enhanced hydrogen yield [33].
\n
\n
\n
6.2. Pyruvate
\n
Pyruvate, a product of glycolysis, serves as an effective starting material for the synthesis of many drugs and agrochemicals and is presently used in the food industry. By combining adaptive evolution and cofactor engineering, a series of engineered yeasts that can produce pyruvate using glucose as the sole carbon source was obtained. Consequently, the constructed strains were able to produce 75.1 g/L pyruvate, increased by 21% compared with the wild strain. The production yield of this strain reached 0.63 g pyruvate/g glucose [34].
\n
\n
\n
6.3. Propanediol
\n
1,3-propanediol, made from glycerol under anaerobic condition, is a monomer for producing various industrial polymers. Du et al. [35] demonstrated that controlling redox potential at −190 mV was preferable for Klebsiella pneumoniae to ferment glycerol into 1,3-propanediol. They further developed a redox potential–based strategy for screening high productivity strain using the correlation between redox potential level and growth rate [36]. Zheng et al. [37] regulated redox potential under low levels (−200 and −400 mV) during 1,3-propanediol fermentation in order to avoid the accumulation of by-product. Wu et al. [38] engineered the pathways of 2,3-butanediol and formic acid in a recombinant K. pneumonia to improve 1,3-propanediol production. The intracellular metabolic flux was redistributed pronouncedly by shrinking all nonvolatile by-products and supplying the availability of NADH. Jain et al. [39] established novel metabolic pathways for 1,2-propanediol in E. coli by disrupting the major competing pathways for acetate production as well as the ubiquinone biosynthesis pathway that conserved more NADH.
\n
\n
\n
6.4. Butanol
\n
Butanol attracts public attentions due to its favorable physicochemical properties for blending with or for directly substituting for gasoline. Fermentation of butanol by C. acetobutylicum is generally a biphasic process consisting of acidogenesis and solventogenesis. It has been reported that an earlier initiation of solvent genesis under redox potential control at −290 mV could increase solvent production by 35% [40]. Li et al. [41] supplemented nicotinic acid, the precursor of NADH and NADPH, into the growth medium, and led to a significant increase of NADH and NADPH levels for a wild-type Clostridium sporogenes strain. As a result, the metabolic pattern was shifted toward the production of more reduced metabolites, in which butanol production was then enhanced. Bui et al. [42] constructed the recombinant K. pneumoniae by overexpressing the genes kivD, leuABCD, and adhE1, with several NADH regeneration strategies to overcome redox imbalance, including the introduction of NAD+-dependent enzymes or elimination of the NADH competition pathway (1,3-propanediol synthesis). The NADH/NAD+ ratio was increased resulting in butanol titer increase [42].
\n
\n
\n
6.5. Butanediol
\n
2,3-butanediol (2,3-BD) is a promising bulk chemical with extensive industry applications. In order to enhance the production of 2,3-BD, various strategies for increasing the NADH availability were developed through regulation of low dissolved oxygen, supplement of reducing substrates and gene modification. An udhA encoding transhydrogenase was introduced and more NADH from NADPH was provided to allow the enhancement of production [43]. For the same reason, two NADH regeneration enzymes, glucose dehydrogenase and formate dehydrogenase, were introduced into E. coli with 2,3-butanediol dehydrogenase, respectively [44]. In other case, an engineered S. cerevisiae harboring NADH oxidase gene (noxE) from L. lactis minimized glycerol accumulation, because intracellular NADH/NAD+ ratio was decreased substantially and carbon flux was redirected to 2,3-BD from glycerol [23].
\n
\n
\n
\n
7. Redox potential process design: a case study of ethanol fermentation
\n
Fuel ethanol, the most successful renewable energy so far, is produced worldwide and applied in transportation as alternative to fossil fuel. However, the high cost associated with bioethanol production urges researchers to innovate new fermentation technologies like redox potential–controlled ethanol fermentation. In this section, the role of redox potential in S. cerevisiae pathways, the correlation between yeast growth and redox potential, and the application of redox potential to very high gravity fermentation will be reviewed.
\n
\n
7.1. The role of redox potential in yeast pathway
\n
\nS. cerevisiae has been considered as a model microorganism, whose genome, proteome, and relevant pathway information are almost unveiled. As illustrated in Figure 4, glucose is converted into small molecules through the coupling of redox reactions, in which NADH plays an essential role in key metabolites production such as ethanol, glycerol, and lactate. In this process, glucose is oxidized by NAD+ to make pyruvate and NADH. The surplus of reducing power is then balanced by the formation of glycerol and ethanol, where NAD+ is restored. When the growth environment favors the production of acetic acid, the implementation of redox potential control can alter the trend, leading to a more reduced state toward ethanol production.
\n
Compared with other control parameters, such as temperature, pH, and the ingredients of medium, redox potential has less influence on improving fermentation results. Hence, the implementation of redox potential control in ethanol fermentation was not popular until the new concept of “very high gravity (VHG)” was proposed. VHG is generally regarded as the final ethanol concentration is greater than 15% (v/v) or initial glucose concentration is greater than 250 g/L. VHG is a promising technology to reduce energy consumption and labor cost, as well as elevate the efficiency of the fermenter. However, high sugar concentration depresses cell growth and bioconversion. Redox potential control helps cells survive from osmotic pressure and ethanol toxicity by constructing healthier membranes or other potential mechanisms. Yeast grown under VHG condition without redox potential control requires much longer fermentation times in order to completely utilize substrate [45]; therefore, the improvement of ethanol production by redox potential control would be expected.
\n
Figure 4.
Metabolic pathway of glucose degradation in Saccharomyces cerevisiae.
\n
Lin et al. [45] controlled redox potential under −150 mV, −100 mV, and no control conditions and demonstrated that VHG ethanol fermentation under −150 mV resulted in the highest final ethanol concentration and the highest ethanol-to-glucose yield. Compared with the case of 200g glucose/L, the effect of redox potential control becomes significant under VHG conditions [45]. Jeon and Park [46] cultivated Zymomonas mobilis and S. cerevisiae to produce ethanol in two separate compartments of an electrochemical bioreactor. The results showed that Z. mobilis favors the reducing environment, but S. cerevisiae produced more ethanol under higher redox potential conditions [46]. Na et al. [47] observed that ethanol production was enhanced in the anode compartment than in the cathode one, although the reduced environment would be better for fermentation process.
\n
\n
\n
7.2. Correlation between cell growth and redox potential
\n
During ethanol fermentation, changes of redox potential are caused by two major substances, electron donor NAD(P)H resulting from dissimilatory processes (e.g. glycolysis) and assimilatory processes (e.g. biomass formation), and electron acceptor oxygen dissolved from sparging and/or agitation. The redox potential profiles are thus correlated to cellular activities and oxygen tension.
\n
A typical redox potential profile resembles a bathtub curve. In the beginning, yeast was inoculated into the autoclaved medium where redox potential is as high as normal oxygen tension. Yeast consumes oxygen as the final electron acceptor during respiration process for rapid propagation, causing a steep fall of redox potential (Stage I, Figure 5). When dissolved oxygen is nearly depleted, yeast modulates the respiratory requirement from aerobic to anaerobic stages where a short transition is seen in order to alter relevant gene expression and pathways (between Stage I and II, Figure 5). After adjustment, yeast cells accelerate their growth rate in the exponential phase with rapid glucose utilization. Although ethanol production is a redox neutral process in theory, the use of reducing substrate like sugar tends to lower fermentation redox potential. The trend of decline in redox potential continues as fermentation proceeds and could drop as low as to −300 mV if there is no other oxidizing reagent present in the fermentation broth (Stage II–III, Figure 5). Due to the substrate depletion and the decline of cell viability attributed to ethanol toxicity, the lowest trough in redox potential level is observed (Stage III, Figure 5). Near the end of fermentation, an abrupt increase in redox potential is attributed to constant aeration or well agitation. Technically, an uprising curve appearing reveals that the fermentation is about to finish (Stage IV, Figure 5).
\n
Figure 5.
Profiles of redox potential, biomass, and dissolved oxygen.
\n
\n
\n
7.3. Process design using redox potential
\n
The performance of VHG ethanol fermentation can be further improved by (1) searching for the optimal redox potential setting and (2) extending redox potential control period to prolong the exponential growth phase. Three redox potential control schemes are collected [48]. The simple aeration-controlled scheme (ACS) has a short redox potential–controlled period. For glucose-controlled feeding scheme (GCFS), glucose was supplemented along with dissolved oxygen presented in the feed stream. For combined chemostat and aeration-controlled scheme (CCACS), a constant glucose was fed along with air supply determined by redox potential–controlled device. The GCFS extends the redox potential–controlled period by offering enough glucose for yeast propagation and maintaining the low residual glucose. As a result, the ethanol yield is increased noticeably. The operation of GCFS as a fed batch, as such the buildup of ethanol causes yeast cessation, resulting in incomplete fermentation. The CCACS is a set of continuous equipment that feeds the fresh medium into a fermenter and discharge spent broth into aging vessels at a constant dilution rate. Sterilized air was used to adjust the fermentation redox potential at a predetermined level. In the chemostat fermenter, both intracellular and extracellular factors should reach their respective steady states. Thus, constant growth rate and yeast viability are sustained under a preset redox potential level, which is helpful to prolong the redox potential–controlled duration and to maximize the benefits from redox potential control. The CCACS achieved the longest controlled period and the highest ethanol yield among all three schemes. However, a chemostat device alone could not result in zero glucose discharge. The incorporation of aging vessel design into fermentation operation thus was developed [49].
\n
\n
\n
\n
8. Future work of redox potential and fermentation
\n
Although many fermentation processes have been well developed with long-term operability, cost saving is an endless effort, particularly for the production of biofuels and bio-based chemicals at bulk quantity. Every penny in cost savings is destined to bring huge economic returns. Since redox reactions and homeostasis are the basis for intracellular metabolism, monitoring and controlling redox potential status inside a cell could potentially re-route metabolic material and energy flow. Numerous works have been done and confirmed that proper redox potential control could alter cellular metabolism, thereby enhancing the conversion of targeted metabolites.
\n
Figure 6.
Research and prospect in redox potential–controlled fermentation.
\n
With the availability of technologies that can detect intracellular redox potential levels, an integrated approach, including gene expression, protein biosynthesis, and biomolecular interacting network, should be employed to identify effects of redox potential control on the multiple hierarchy (Figure 6). The underlying mechanism of this phenomenon can then be elucidated at molecular and bioprocess engineering levels. The more details obtained, the better applications of redox potential control can be exploited. Consequently, robust strains and optimized processes can be developed toward high-yield production.
\n\n
Future perspective of redox potential control is attractive. Fermentation will be carried out using gene-modified strains featuring tailor-made redox potential balance. The strain will be subjected to tight regulation through precise redox potential level. Metabolic flux profiles obtained at different redox potential levels will be quantified to achieve the maximum production of various desired metabolites or used to locate potential bottleneck for strain improvement. Benefits from the development of new redox potential–controlled fermentation technology are thus anticipated.
\n
\n\n',keywords:"redox potential, ORP, fermentation, bioprocess, ethanol",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/51634.pdf",chapterXML:"https://mts.intechopen.com/source/xml/51634.xml",downloadPdfUrl:"/chapter/pdf-download/51634",previewPdfUrl:"/chapter/pdf-preview/51634",totalDownloads:3651,totalViews:2153,totalCrossrefCites:4,totalDimensionsCites:16,totalAltmetricsMentions:0,introChapter:null,impactScore:5,impactScorePercentile:93,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"November 25th 2015",dateReviewed:"June 17th 2016",datePrePublished:null,datePublished:"February 8th 2017",dateFinished:"July 7th 2016",readingETA:"0",abstract:"Redox potential, known as oxidation–reduction or oxidoreduction potential (ORP), not only indicates the reduction and oxidation capacity of the environment but also reflects the metabolic activity of microorganisms. Redox potential can be monitored online and controlled in time for more efficient fermentation operation. This chapter reviews the enzymes that modulate intracellular redox potential, the genetically engineered strains that harbor specific redox potential–regulated genes, the approaches that were used to manipulate and control redox potential toward the production of desired metabolites, the role of redox potential in metabolic pathway, and the impact of redox potential on microbial physiology and metabolism. The application of redox potential–controlled ethanol fermentation and the development of three redox potential–controlled fermentation processes are illustrated. In the end, the future perspective of redox potential control is provided.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/51634",risUrl:"/chapter/ris/51634",book:{id:"5305",slug:"fermentation-processes"},signatures:"Chen-Guang Liu, Jin-Cheng Qin and Yen-Han Lin",authors:[{id:"183019",title:"Prof.",name:"Yen-Han",middleName:null,surname:"Lin",fullName:"Yen-Han Lin",slug:"yen-han-lin",email:"yenhan.lin@usask.ca",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Saskatchewan",institutionURL:null,country:{name:"Canada"}}},{id:"183927",title:"Dr.",name:"Chen-Guang",middleName:null,surname:"Liu",fullName:"Chen-Guang Liu",slug:"chen-guang-liu",email:"sunshine_liu2@163.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Saskatchewan",institutionURL:null,country:{name:"Canada"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Basic theory of redox potential",level:"1"},{id:"sec_3",title:"3. Extracellular redox potential",level:"1"},{id:"sec_3_2",title:"3.1. Control extracellular redox potential by energy input",level:"2"},{id:"sec_4_2",title:"3.2. Control extracellular redox potential by redox reagents",level:"2"},{id:"sec_5_2",title:"3.3. Control extracellular redox potential by gas sparging",level:"2"},{id:"sec_6_2",title:"3.4. Extracellular redox potential and dissolved oxygen",level:"2"},{id:"sec_8",title:"4. Intracellular redox potential",level:"1"},{id:"sec_8_2",title:"4.1. Universal redox pairs in a cell",level:"2"},{id:"sec_9_2",title:"4.2. Redox effect across the membrane",level:"2"},{id:"sec_10_2",title:"4.3. Effects of redox potential on a cell",level:"2"},{id:"sec_12",title:"5. Redox potential and metabolic flux",level:"1"},{id:"sec_12_2",title:"5.1. Alternative oxidase",level:"2"},{id:"sec_13_2",title:"5.2. Formate dehydrogenase",level:"2"},{id:"sec_14_2",title:"5.3. NADH oxidase",level:"2"},{id:"sec_15_2",title:"5.4. NADH kinase",level:"2"},{id:"sec_17",title:"6. Application of redox potential to fermentation processes",level:"1"},{id:"sec_17_2",title:"6.1. Hydrogen",level:"2"},{id:"sec_18_2",title:"6.2. Pyruvate",level:"2"},{id:"sec_19_2",title:"6.3. Propanediol",level:"2"},{id:"sec_20_2",title:"6.4. Butanol",level:"2"},{id:"sec_21_2",title:"6.5. Butanediol",level:"2"},{id:"sec_23",title:"7. Redox potential process design: a case study of ethanol fermentation",level:"1"},{id:"sec_23_2",title:"7.1. The role of redox potential in yeast pathway",level:"2"},{id:"sec_24_2",title:"7.2. Correlation between cell growth and redox potential",level:"2"},{id:"sec_25_2",title:"7.3. Process design using redox potential",level:"2"},{id:"sec_27",title:"8. Future work of redox potential and fermentation",level:"1"}],chapterReferences:[{id:"B1",body:'\nNeedham J G. Curtis gates lloyd. 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Effect of culture conditions on 3-hydroxy- propionaldehyde detoxification in 1,3-propanediol fermentation by Klebsiella pneumoniae. Biochemical Engineering Journal. 2008;39:305-310. DOI: 10.1016/j.bej.2007.10.001\n'},{id:"B38",body:'\nWu Z, Wang Z, Wang G. Improved 1,3-propanediol production by engineering the 2,3-butanediol and formic acid pathways in integrative recombinant Klebsiella pneumoniae. Journal of Biotechnology. 2013;168:194-200. DOI: 10.1016/j.jbiotec.2013.04.022\n'},{id:"B39",body:'\nJain R, Huang J, Yuan Q. Engineering microaerobic metabolism of E. coli for 1,2-propanediol production. Journal of Industrial Microbiology & Biotechnology. 2015;42:1049-1055. DOI: 10.1007/s10295-015-1622-9\n'},{id:"B40",body:'\nWang S, Zhu Y, Zhang Y. Controlling the oxidoreduction potential of the culture of Clostridium acetobutylicum leads to an earlier initiation of solventogenesis, thus increasing solvent productivity. Applied Microbiology and Biotechnology. 2012;93:1021-1030. DOI: 10.1007/s00253-011-3570-2\n'},{id:"B41",body:'\nLi T, Yan Y, He J. Reducing cofactors contribute to the increase of butanol production by a wild-type Clostridium sp. strain BOH3. Bioresource Technology. 2014;155:220-228. DOI: 10.1016/j.biortech.2013.12.089\n'},{id:"B42",body:'\nBui L M, Lee J Y, Geraldi A. Improved n-butanol tolerance in Escherichia coli by controlling membrane related functions. Journal of Biotechnology. 2015;204:33-44. DOI: 10.1016/j.jbiotec.2015.03.025\n'},{id:"B43",body:'\nFu J, Wang Z W, Chen T. NADH plays the vital role for chiral pure D-(-)-2,3-Butanediol production in Bacillus subtilis under limited oxygen conditions. Biotechnology and Bioengineering. 2014;111:2126-2131. DOI: 10.1002/bit.25265\n'},{id:"B44",body:'\nWang Y, Li L, Ma C. Engineering of cofactor regeneration enhances (2S,3S)-2,3-butanediol production from diacetyl. Scientific Reports. 2013;3:2643. DOI: 10.1038/srep02643\n'},{id:"B45",body:'\nLin Y H, Chien W S, Duan K J. Correlations between reduction-oxidation potential profiles and growth patterns of Saccharomyces cerevisiae during very-high-gravity fermentation. Process Biochemistry. 2010;45:765-770. DOI: 10.1016/j.procbio.2010.01.018\n'},{id:"B46",body:'\nJeon B Y, Park D H. Improvement of ethanol production by electrochemical redox combination of Zymomonas mobilis and Saccharomyces cerevisiae. Journal of Microbiology and Biotechnology. 2010;20:94-100. DOI: 10.4014/jmb.0904.04029\n'},{id:"B47",body:'\nNa B K, Hwang T S, Lee S H. Effect of electrochemical redox reaction on growth and metabolism of Saccharomyces cerevisiae as an environmental factor. Journal of Microbiology and Biotechnology. 2007;17:445-453.\n'},{id:"B48",body:'\nLiu C G, Lin Y H, Bai F W. Development of redox potential-controlled schemes for very-high-gravity ethanol fermentation. Journal of Biotechnology. 2011;153:42-47. DOI: 10.1016/j.jbiotec.2011.03.007\n'},{id:"B49",body:'\nLiu C G, Lin Y H, Bai F W. Ageing vessel configuration for continuous redox potential-controlled very-high-gravity fermentation. Journal of Bioscience and Bioengineering. 2011;111:61-66. DOI: 10.1016/j.jbiosc.2010.09.003\n'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Chen-Guang Liu",address:null,affiliation:'
State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China
Department of Chemical and Biological Engineering, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
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1. Introduction
The Republic of Suriname is a small independent country in South America that is renowned for its ethnic, cultural, and religious diversity [1]. The Javanese are currently the fourth most numerous ethnic group in Suriname, after the Hindustanis, the Creoles, and the Maroons [1]. The Javanese are the descendants of indentured laborers from particularly the Indonesian island of Java who were attracted by the Dutch colonizers from the former Dutch East Indies - modern-day Indonesia - at the end of the 19th century to work on the sugar cane plantations in Suriname following the abolition of slavery in the year 1863 [2, 3]. They had signed contracts for five years, and although some returned to their home country and others relocated to The Netherlands [2, 3], most remained in Suriname and settled in the district of Commewijne (Figure 1) where the first groups of Javanese had been put to work [2, 3].
Figure 1.
Location of Suriname with respect to its neighboring countries French Guiana, Brazil, and Guyana, as well as its poisoning in South America (insert) (modifed from: https://goo.gl/images/F77jgS).
Today, only five generations later, the Javanese have integrated well in Suriname, actively participating in all sections of the society including politics, arts, entertainment, and sports. For instance, Iding and Willy Soemita and Paul Somohardjo were prominent Surinamese Javanese politicians. Iding Soemita was born in West Java and came as an indentured laborer to Suriname, and founded the political party Kerukunan Tulodo Pranatan Inggil (KTPI) in 1949, giving Surinamese Javanese for the first time a political voice. Iding Soemita’s son Willy succeeded his father as chairman of the KTPI in 1972 and served several times as a minister until 1996. As a more outspoken and assertive alternative to the KTPI, Paul Somohardjo founded the Javanese party Pendawa Lima in 1977 that was superseded in 1998 by the Pertjajah Luhur. Somohardjo became the first-ever Javanese Speaker of the National Assembly in 2005 and also served several terms as a minister.
The Surinamese-Javanese writer Karin Amatmoekrim studied Modern Literature at the University of Amsterdam, graduated with a thesis on ‘The ethnicity in literature in Suriname’, and won the 2009-Black Magic Woman Literature Prize for her novel ‘Titus’. The Surinamese-Javanese singers Ragmad Amatstam, Oesje Soekatma, and Eddy Assan are among the greatest and most beloved musicians Suriname has brought forth. Specializing in pop-Jawa songs, they reached a broad audience in both Suriname and The Netherlands. Notable Surinamese-Javanese sports heroes are Andy Atmodimedjo, Virgil Soeroredjo, and Mitchel Wongsodikromo. Andy Atmodimedjo was an impressive professional football player and became the successful manager of several clubs in Suriname’s highest soccer league as well as the head coach of the country’s senior and under-21 national soccer teams. And Virgil Soeroredjo and Mitchel Wongsodikromo were among the world’s top badminton players who excelled on various national, Caribbean, Central American, and South American competitions.
Nevertheless, the Javanese have preserved their own identity, speaking their own language and adhering to their own specific religious and cultural customs. This also holds true for their traditional medical customs which are based on Jamu, the centuries-old traditional form of medicine from Indonesia that mainly involves the use of plants with medicinal properties. The first part of this chapter gives some background on Suriname; then addresses some of the religious and cultural expressions of Surinamese Javanese; focuses on Jamu, and concludes with an extensive account of the traditional, phytochemical, and pharmacological aspects of four medicinal plants that are mainly used by Surinamese Javanese. The second part of the chapter continues with a comprehensive narrative about six additional popular ‘Javanese’ medicinal plants and concludes with the contribution of the Javanese pharmacognostic knowledge to Suriname’s traditional medicinal pharmacopeia.
2. Background on Suriname
2.1 Geography, population, and economy
The Republic of Suriname is located in the north-eastern part of South America, bordering the Atlantic Ocean to the north, French Guiana to the east, Guyana to the west, and Brazil to the south (Figure 1). It is the smallest sovereign country in South America with a land area of about 165,000 km2 that can be distinguished into a relatively narrow northern coastal region and a large, sparsely inhabited hinterland that is mainly covered by savanna grassland and pristine Amazon rain forest [4]. Suriname’s capital and largest city is Paramaribo that is located in the coastal area near the mouth of the Suriname River (Figure 1) and harbors, together with the other cities in the coastal area, approximately 80% of the population [1]. The hinterland encompasses more than three-quarters of the country’s surface and [4] and is home to the remaining 20% of Suriname’s inhabitants [1].
The population is among the ethnically most varied in the world, comprising Amerindians, the original inhabitants; Maroons, the immediate descendants of enslaved Africans shipped from western Africa between the 17th and 19th centuries; mixed people descending from enslaved Africans and mostly Europeans called Creoles; the descendants from indentured laborers attracted from China and India in addition to Java (Indonesia) between the second half of the 19th century and the first half of the 20th century; and immigrants from various European, South American, and Caribbean countries [1]. According to the 2012 census, the largest groups are represented by the Hindustanis, Maroons, Creoles, and Javanese, making up roughly 27, 22, 17, and 16%, respectively, of the total Surinamese population [1].
Suriname is situated on the Guiana Shield, a Precambrian geological formation estimated to be 1.7 billion years old and one of the regions with the largest expanse of undisturbed tropical rain forest in the world, with an extraordinary high animal and plant biodiversity [4]. The high mineral density of Suriname’s soil contributes to its ranking as the 17th richest country in the world in terms of natural resources and development potential [5]. Suriname’s most important economic means of support are crude oil drilling, gold mining, agriculture, fisheries, forestry, and ecotourism [5]. These activities contributed substantially to the gross domestic product in 2019 of USD 3,697 billion and the gross per capita income in that year of USD 5,420 [6]. This positions Suriname on the World Bank’s list of upper-middle income economies [6].
2.2 Brief history
Although many history text books discuss Suriname starting from 1492 (the year Christopher Columbus ‘discovered’ South America’s ‘Wild Coast’), archeological finds in Suriname’s deep south-west have demonstrated the presence of human beings in Suriname as far back as 5,000 years ago [7]. The artifacts have been ascribed to nomadic Amazon tribes who then lived in that region and who may represent the ancestors of the present-day Indigenous tribes who still populate Suriname’s hinterland. One of these nomadic tribes are the Arawaks, who are generally believed to be Suriname’s original inhabitants [8], but there are no written documents to support this assumption.
Dozens of years after Columbus, the first Europeans arrived in Suriname in the early 1600s. They were Spanish, English, French and Dutch fortune hunters who were in search of El Dorado, a mythical city of immense wealth somewhere at the ‘Wild Coast’ ruled by a chieftain covered with gold dust [9]. The area was first colonized in 1630 by British settlers led by Captain John Marshall [10], and they called the occupied region ‘Surinam’ after the Surinen indigenous people they had encountered. Their attempt to set up tobacco plantations failed and they abandoned the colony by 1645 [10].
A second English operation undertaken in 1651 was more successful when permanent sugar cane plantations were established in the colony that had been named Willoughbyland in honor of their patron Lord Francis Willoughby, the then governor of Barbados [10]. Initially, cheap labor to work on the plantations was mainly provided by captured Indigenous tribespeople from the hinterland. However, because of the increasing need for laborers, the British started importing enslaved Africans in 1663 from Dutch centers for slave trading in western Africa [10]. In the resulting conflict, the Dutch invaded and captured Willoughbyland in 1667 [10]. This eventually led to settlements in which Suriname was assigned to The Netherlands in exchange for New Amsterdam in North America [11]. The Dutch renamed Willoughbyland Dutch Guiana, while the English renamed New Amsterdam New York after the Duke of York [11].
From 1683 onwards, the Dutch ruled over their newly acquired colony in South America, elevating the plantation economy to unprecedented heights by producing cocoa, coffee, cotton, sugar, and indigo [12]. The Dutch also dominated the trans-Atlantic slave trade for a long time, transporting a total of approximately 300,000 Africans to Suriname [12]. However, treatment of the enslaved Africans was notoriously brutal, and many escaped to Suriname’s hinterland [13]. These Maroons preserved much of their cultural concepts and established a new and unique culture that was highly successful and exists until today [13].
Slavery was officially abolished in 1863, but the enslaved Africans who had remained on the plantations were obliged to conduct ill-paid work over the next ten years. As soon as they became truly free, the majority abandoned the plantations and settled in Paramaribo [14]. To make up for the shortage of workers on the plantations after 1873, indentured laborers were brought in, first from India then from the then Dutch East Indies [2]. In addition, between 1850 and 1860, small numbers of (mostly male) laborers had been brought in from China and the Middle East [15]. From the mid-20th century onwards, various immigrants from South American and Caribbean countries immigrated to Suriname [5]. These developments are the reason that Suriname has become one of the ethnically and culturally most diverse countries in the world notwithstanding its relatively small population. It also explains the large variety of traditional forms of medicine practised in the country.
3. Surinamese Javanese
3.1 The first arrivals
The first group of 94 Javanese indentured laborers was from the countryside of the city of Surakarta in Java (also known as Solo) and left on May 21, 1890, for Suriname on the steamship Prins Willem II [16]. This was an initiative of the Netherlands Trading Society (Nederlandsche Handel-Maatschappij, abbreviated NHM), one of the primary ancestors of ABN AMRO Bank NV, the third-largest bank in The Netherlands. The Prins Willem II arrived 70 days later, on August 9, 1890, in Suriname [16]. Lately, this date has been proclaimed a national holiday in commemoration of the Javanese immigration. The new arrivals were set to work on the sugar cane plantations at Mariënburg (district Commewijne) which were then owned by the NHM.
The NHM initiative was considered successful, and by 1894 the Dutch colonial government took over the task of recruiting Javanese hands starting with signing up 584 additional Javanese in that year [16]. The workers (and their families) arrived in small groups and in two stages, i.e., first from the Dutch East Indies to The Netherlands and from there to Paramaribo [16] (Figure 2). They came from the then overpopulated villages in central and western Java, Batavia, Surabaya, and Semarang, and awaited their departure in depots in Batavia, Semarang, and Tandjong Priok, where they were inspected and registered and signed their contract [16]. The transport of Javanese indentured laborers continued until 13 December 1939, when it was discontinued by the outbreak of World War II [16].
Figure 2.
Arrival of one of first groups of Javanese indentured laborers in Suriname (from: https://images.app.goo.gl/cwD6eX97BovonbgR6).
In total, 32,956 Javanese arrived in Suriname. Most of them were recruited to work on the plantations, but a group was also specifically recruited to work at the Colonial Railways, while another group was assigned to the Suriname Bauxite Company in Moengo during World War I [16]. Only 20 to 25% of the Javanese migrants returned to their home country before World War II [2, 3]. In 1954, an additional 1,200 Javanese, encouraged by Iding Soemita’s rival Salikin Hardjo, returned to Indonesia to start an agricultural co-operative in Tongar in western Sumatra [2, 3]. And in the 1970s, 20,000 to 25,000 Surinamese Javanese went to The Netherlands for fear of social-economic insecurity in an independent Suriname that was due in 1975 [2, 3]. However, the great majority of Javanese immigrants settled permanently in Suriname,
Nevertheless, many Javanese identified and still identify with their country of origin, even though very few have ever visited Java or maintain family connections there. This strong adherence to their origin is partly due to the major socio-economic disadvantages they had to face in an often hostile environment [16, 17]. In addition, the firm commitment of many Javanese to their own customs and traditions is for an important part directly attributable to Dutch colonial policies to control the immigrants [16, 17]. This was done through the so-called ‘Indianisation’ project implemented in the 1930s and involved, among others the creation of small Indonesian-styled Javanese farm villages - desas - in the countryside, each headed by its own village head (the lurah) and religious and civic leaders [16, 17]. Obviously, this secluded lifestyle strengthened the group identity and helped them to maintain the rich culture they had brought with them from Java [16, 17]. Indeed, some of the desas were situated in locations that are still mainly populated by Javanese such as Tamanredjo, Kampong Baru, Sidoredjo, and Kuwarasan as well as Lelydorp, Domburg, and Meerzorg.
3.2 Javanese culture
The social, economic, linguistic, cultural, and religious challenges the Javanese indentured laborers had to cope with, obviously contributed to the consolidation of the group cohesion and the preservation of their customs and traditions. For instance, the Surinamese Javanese still speak their own language in addition to Dutch, the official language of government, business, media, and education, as well as Surinamese or Sranan Tongo, the widely used English- and Portuguese-based lingua franca [18]. The language spoken by this group is Surinamese-Javanese that is derived from the original Javanese language called Basa Jawa spoken in the central and eastern parts of Java [19]. However, after more than a century, Surinamese-Javanese has become influenced by Dutch and Sranan Tongo and has developed differently from Basa Jawa [19].
Most Javanese are Muslim, and one of the central values in their philosophy about life is rukun that involves a commitment to harmony and togetherness, not only among people but also between the human world and that of the gods and the spirits. The importance of rukun manifests in Javanese everyday-life in, for instance, the pursuit of good relations with others, an attitude of modesty, courtesy, politeness, formality, and avoiding conflicts whenever possible. Rukun is also expressed in several ceremonies and rituals for maintaining good relations with the gods and the spiritual world [20]. This is mainly done by making sacrifices and holding ritual sacrificial meals or slametans. A slametan is headed by a religious leader called kaum who asks God to bless the various dishes spread out on the table, each with a specific ritual meaning based on the purpose of the slametan [20].
Unique cultural expressions from the Javanese are the gamelan music, the wayang shadow puppet show, and the ludruk theater. Gamelan (Figure 3) is the traditional ensemble music of Javanese and is predominantly performed by different percussion instruments such as metallophones and xylophones played by mallets, chimes, and hand-played drums called kendhang to register the beat, as well as melodic instruments like bamboo flutes, strings, and vocalists called sindhen if female or gerong if male [21]. The earliest known records of gamelan were found in the reliefs of the Borobudur Temple located near Central Java, the world’s largest Buddhist temple, dating it back as far as the 9th century [21]. Gamelan is commonly played in many religious rituals, traditional ceremonies, and informal events, including, among others, wajang puppet shows and ludruk theater [21].
Wajang is an ancient form of storytelling by theater play that dates back to medieval times [22]. The form most practiced is called wajang kulit that depicts dramatic mythological stories as well as local adaptations of cultural legends using flat leather shadow puppets [22]. A wajang is played out by the dalang, the puppeteer who sits behind the screen and sings and narrates the dialogs of the different characters of the story [22]. The dalang is highly respected for his knowledge and art, and as a spiritual person capable of bringing to life the spiritual stories in the religious epics [22]. Ludruk theater is the old Javanese tradition of storytelling presented by a group of actors (or comedians) on a stage, through slow, graceful, and expressive dances [23]. Ludruk presumably dates as far back as the 13th century [23]. It tells stories about everyday life, mostly that of the underprivileged, and is particularly appreciated by a working-class audience [23].
Other characteristic Javanese cultural expressions are djarang kepang and pentjak silat. Djarang kepang (Figure 4) is a spectacular cultural religious tradition where young males dance on hobby horses and suddenly become entranced, behaving like horses and eating grass [24]. It is generally performed in a cordoned-off area, with the audience separated from the dancers [24]. The origin of djarang kepang is uncertain, but it may be based on the wars fought between native Javanese and the colonial Dutch Empire in the dying days of the Sultanate of Mataram at the end of the 19th century and during the Diponegoro War from 1825 to 1830 [24]. Pentjak silat is the indigenous ritual martial art of Indonesia intended for self defense [25]. It is believed to be founded as early as the 6th century and has extensively been practised during the epoch of the powerful kingdom of Sri Vijaja on Sumatra in the 11th century [25]. Pentjak silat is based on the movements and stances of tigers, eagles, snakes, crocodiles, monkeys, scorpions, and dragons [25]. As a result, some of the stances and styles have been named after animals, such as harimau (tiger) and garuda putih (white eagle) [25].
Figure 4.
Performers of djarang kepang (https://images.app.goo.gl/KVF2xzwUAzqmr8ac6).
3.3 Jamu
The Surinamese Javanese have also maintained their traditional medical customs which are mainly based on medicinal plants and, as mentioned above, are referred to as Jamu [20]. Jamu is widely practiced in Indonesia and probably has its origin in the Mataram Kingdom era in ancient Java, some 1300 years ago [26, 27]. Jamu products called jamus are in Indonesia traditionally available from (particularly female) peddlers and street-side vendors, entrepeneurs who operate on a made-to-order basis out of their home, as well as medium-sized and large firms that produce and retail pre-made jamus in dried form, sachet packaging, and as tablets, capsules, and liquid drinks [26, 27]. The many different Jamu brands are united in the Indonesian Herbal and Traditional Medicine Association locally known as Gabungan Pengusaha Jamu that had sales worth USD 74 million in 2014 [26, 27].
There are jamus against almost every ailment, ranging from remedies for treating sick children and managing post-childbirth conditions to a large variety of beauty products and remedies for sexual problems [28]. The medicine book from Mataram from the 18th century even has 3,000 entries of jamu recipes [28]. An example is jamu kunirasem that contains as main ingredients the rhizome from the turmeric Curcuma longa L. (Zingiberaceae) called kunjit or kunir in Javanese, and parts from the tamarind Tamarindus indica L. (Caesalpiniaceae) called asem in Javanese [28]. Another example is jamu beraskentjur that has as basic ingredients rice (beras in Javanese) and the rhizome from the sand ginger Kaempferia galanga L. (Zingiberaceae) called kentjur in Javanese [28]. However, depending on the desired benefits, various other ingrededients are added, such as ginger rhizome, cardamom seeds, cinnamon, pomegranate, lemon, and/or nutmeg [28]. To improve the (sometimes bitter or sour) taste, natural sweeteners such as brown sugar, granulated sugar, rock sugar or honey may be added [28].
Jamu is practiced in both Indonesia and Suriname by highly respected medicinal practitioners known as dukuns [20, 26, 29]. The dukun is very influential and holds extensive knowledge about the preparation of the large variety of sometimes rather complicated jamus [20, 26]. An example is the very popular jamu galian consisting of different parts of eight plants that is widely used in Suriname as a general health-promoting tonic [20, 26, 29]. The dukun also plays an important role during, for instance, njuwuk, a ritual to bring a person at ease by praying over and blowing three times over a glass of water that then must be drunk by the client [20, 26, 29]. Njuwuk is often performed prior to examinations, circumcisions, or giving birth [20, 26].
4. Plants used in Javanese pharmacognosy
Hereunder, four medicinal plants that are traditionally mainly used by Surinamese Javanese, have in detail been assessed for their phytochemical contents and pharmacological activities in order to provide a scientific rationale for their ethnopharmacological applications. The plants have been selected on the basis of the number of times they have been dealt with in a number of comprehensive publications describing the use of medicinal plants in the country [30, 31, 32, 33, 34, 35, 36, 37, 38]. In part 2 of this chapter, six additional plants are equally extensive addressed. All the plants and their main traditional use by Surinamese Javanese are given in Table 1.
Family
Species (vernacular names in English; Surinamese-Javanese)
Part(s) used
Traditional indications
References
Acanthaceae
Strobilanthes crispa Blume (black face general; ketji beling)
Leaf
Disorders of the urinary system; diabetes mellitus
Plants commonly used in Javanese traditional medicine addressed in this chapter, parts preferentially used, and traditional indications in the Surinamese-Javanese community.
4.1 Acanthaceae - Strobilanthes crispa Blume
The black face general S. crispa, known as ketji beling in Suriname (Figure 5), is native to the region between Madagascar and Indonesia but is now found in many countries throughout south-eastern Asia. It is a woody spreading shrub that carries yellow-colored flowers, attains a height of 50 centimeters to 1 meter, and can be found on riverbanks and abandoned fields. The leaf is eaten as a vegetable but has for centuries been used medicinally in Indonesian and Malaysian folk medicine. More recently, some products prepared from S. crispa leaf have entered the health-food market as nutraceuticals in the form of sachets containing the raw crude powder for preparing a tea, as an additive in coffee, or as capsules for oral intake. S. crispa has probably been introduced in Suriname from Java in 1956 [32], and mainly the leaf is used as an ingredient of popular jamus for lowering elevated blood sugar levels [34]. In Suriname, it is also used as a diuretic, against kidney stones and renal colics, and to lower elevated blood sugar levels in diabetes mellitus [34], either separately or in combination with, for instance, the leaves from the cat’s whiskers Orthosiphon grandiflorus Bold. (Lamiaceae) [34].
Figure 5.
The black face general Strobilanthes crispa Blume (Acanthaceae) (from: https://images.app.goo.gl/8miNujrVKRRNs5N79).
Some of these traditional uses are supported by experimental data and pharmacological studies. The use of the leaf as a mild diuretic [39] can be attributed to the many cystoliths of calcium carbonate in this part of the plant [40], which make an infusion slightly alkaline. Support for the anti-urolithiatic properties of S. crispa and its efficacy against renal colics came from the inhibitory activity of methanolic and ethyl acetate leaf extracts against the aggregation of calcium oxalate crystals and their stimulatory effects on the dissolution of the crystals [41]. The results from a clinical trial with a polyherbal formulation containing S. crispa suggested that it was safe and effective in the treatment of urolithiasis [42]. It has been suggested that the phenolic compounds in the leaf are responsible for the anti-urolithiatic activity of the plant, as these compounds have been found to inhibit the growth of calcium oxalate crystals in vitro [43].
The use of S. crispa against diabetes mellitus is supported by the antihyperglycemic activities of hot water extracts of fermented and/or unfermented leaf tea in normal and streptozotocin-induced diabetic laboratory rats [44]. Both fermented and unfermented S. crispa tea improved lipid profile in the animals [44]. Comparable results were obtained with S. crispa juice in diabetic and normal rats [45]. Interestingly, the fresh juice from S. crispa leaf stimulated the healing of incision wounds on the back of normal and streptozotocin-induced hyperglycemic rats [46]. These observations are in accordance with the stimulatory effects of a topically applied ethanol extract of S. crispa leaf on excision wounds in the posterior neck area rats [47].
4.2 Acoraceae - Acorus calamus L. 1753
The sweet flag A. calamus, also called dlingu in Surinamese-Javanese (Figure 6), is a species of flowering plant that is widely spread from the Caucasus through western Asia and Siberia to China, India and south-eastern Asia, as well as North America, where it can be found in swampy and marshy habitats. It is a stemless herbaceous perennial that grows about 2 meters tall and is characterized by clusters of leaves arising from a spreading rhizome. The plant has diploid forms (mainly in parts of northern Asia and much of North America), triploid forms (mainly in Europe and south-western Asia to the Himalayas), and tetraploid forms (mainly in central Asia, through India, Japan and tropical Asia) [48]. Each of these forms has a distinct chemistry, particularly with respect to the composition up of the essential oil in leaf and rhizome [49].
Figure 6.
The sweet flag Acorus calamus L. 1753 (Acoraceae) (from: https://images.app.goo.gl/Rt334C1iRQEvLjaT8).
A. calamus has been known since the ancient Egyptians who appreciated the sweet, cinnamon-like scent of the essential oil and incorporated extracts from these parts of the plant into perfumes and aromatic vinegars [50]. In Suriname, A. calamus is only used by the Javanese [34] who incorporate the dried rhizome as a spice in a herbal paste called bumbus [34]. The dried rhizome is also prepared into a tea for treating abdominal cramps, stomach problems, and dysentery [38]; as an ingredient of a number of jamus [34] such as jamu sawanang that is given to children as a deworming treatment and against pinworms; the macerated rhizome mixed with aniseed is placed on the forehead of children with the common cold; as an ingredient of an ointment for treating convulsions and seizures in children; and the grated rhizome is rubbed behind the ears and on the forehead of children to ward off the evil eye and provide protection from evil spirits [34, 38].
Phytochemical studies of A. calamus have shown the presence of a wide variety of chemical constituents in the rhizome and other parts of the plant, including a volatile oil that consists of the phenylpropanoids α-asarone and β-asarone as well as saponins, lectins, sesquiterpenoids, lignans, and steroids [49]. β-Asarone is responsible for the characteristic odor and flavor of A. calamus rhizome and leaf [49] and is present in varying amounts in the essential oils from the diploid, triploid, and tetraploid forms the plant. The oil from the tetraploid form consists for 90 to 95% of β-asarone, that of the triploid form has only relatively small amounts of β-asarone, while the diploid form is devoid of this compound [49]. β-Asarone is potentially carcinogenic and hepatotoxic [51] and can cause hallucinations, as well as severe and prolonged nausea and vomiting [52]. For these reasons, A. calamus-derived products such as the rhizome oil have been banned in the USA and their concentrations as flavorings in, for instance, bitters, have been limited to 115 μg per day [53].
Nevertheless, a great number of pharmacological studies provided support for various Surinamese-Javanese traditional applications of A. calamus. The traditional use of the dried rhizome for gastrointestinal conditions [38] is supported by the inhibitory effects of an ethanolic rhizome extract on gastric secretion in rats and the protective effect of this preparation on the animals’ gastroduodenal mucosa against damage caused by pyloric ligation, indomethacin, reserpine, cysteamine administration, and cytodestructive agents such as ethanol [54]. A 50%-ethanol extract of the rhizome also showed antispasmodic activity in an isolated guinea pig illeum assay in mice [55], while a crude rhizome extract inhibited spontaneous and high K+-induced contractions in an isolated rabbit jejunum preparation, accomplishing spasmolytic activity that might be mediated through calcium channel blockade [56]. Furthermore, a methanolic rhizome extract the considerably reduced induction time of castor oil-induced diarrhea and total weight of the feces in mice [57].
The incorporation of A. calamus rhizome in, among others, jamu sawanang in order to remove intestinal worms and pinworms [34] is justified by the inhibitory effects of extracts of the essential oil against the large roundworm Ascaris lumbricoides [58], the causative agent of ascariasis that causes abdominal swelling, abdominal pain, and diarrhea, as well as poor weight gain, malnutrition, and learning problems in children [59]. Notably, administration of the dried rhizome powder to 147 children aged between 5 and 11 years with round worm infestation produced complete cures in 83% of cases [60]. A. calamus essential oil also displayed nematicidal activity against the root-knot nematode Meloidogyne incognita [61] that arouses large, usually irregular galls on roots of trees [62].
Support for an anticonvulsant activity from A. calamus came from the protective effect of the essential oil on convulsions produced by electroshocks in laboratory rats and mice [63], the reduction in the severity of maximum electric shock-induced seizure in rats by aqueous and alcohol extracts from the rhizome [64], and the significant increase in the pentylenetetrazole-induced seizure latency caused by these extracts [64]. These calming effects of A. calamus preparations may also account, at least partially, for their use to ward off the evil eye and protect against evil spirits [34, 38].
4.3 Arecaceae - Cocos nucifera L.
The coconut tree C. nucifera, known as klapa in Surinamese-Javanese (Figure 7), presumably originates from Indonesia, Malaysia, the Philippines, as well as the many islands between the Indian and the Pacific Ocean. It has subsequently been brought to India, Africa, and the Americas, and is now found in most tropical regions throughout the world. The plant is an evergreen arborescent monocotyledonous tree that can range in height from 2 meters up to 30 meters. C. nucifera is grown for decoration but also for the many culinary, non-culinary, and medicinal uses of virtually every part of the plant. Indeed, coconut oil; coconut milk; coconut water; preparations from the dried coconut meat, husk fiber, leaf, inflorescence, stem, and root; leaves and roots of young plants are widely used in many traditional medical systems throughout the world.
Figure 7.
Coconut tree Cocos nucifera L. (Arecaceae) (from: https://images.app.goo.gl/47JmZznFpMu9eebL7).
In Suriname, small amounts of coconut oil are included in in preparations to fight colds, flu, fever, bronchitis, and astma [32, 34]. Coconut meat is eaten against pimples, or applied on shingles due to herpes zoster infection after it has been macerated by chewing [34]. A tea from the husk fibers is drunk to manage the symptoms of diabetes mellitus and hypertension [38]. Diarrhea and dysentery are treated by drinking coconut water or an infusion of cocos meat with allspice and clove [35]. Coconut water would also stop vomiting and fever [36]. Externally, coconut oil is used for skin and hair care, skin wounds, insect bites, burns, sprains, sore muscles, to massage the abdomen of pregnant women, to promote the health of newborn babies [34], and to protect newborn babies against the evil eye and to command luck in their life [33].
Phytochemical studies showed the presence of many phytochemicals and bioactive compounds in various parts of C. nucifera including, among others, flavonoids and other phenolic compounds having antioxidant properties, condensed tannins with potential antihelminthic activity, macronutrients such as lauric acid that may be involved in the antiprotozoal, antifungal, antibacterial, and antiviral properties of the plant, and micronutrients such as manganese, copper, iron, and selenium [65]. The presence of these compounds in the plant could support some of its traditional applications and could help explain some of its pharmacological activities dealt with hereunder.
The use of C. nucifera preparations against infections of the respiratory tract in Suriname [32, 34] may be attributed to their antibacterial, antifungal, and antiviral properties. Support for the former activity particularly came from the inhibitory effects of preparations from the dried and macerated husk fibers against common oral pathogens like cariogenic bacteria, periodontal pathogens, and candidal organisms albeit the less than that of the disinfectant and antiseptic chlorhexidine [66]; cultures of a broad range of both Gram-positive and Gram-negative pathogenic bacteria [67, 68] including methicillin-resistant Staphylococcus aureus [69]. Other studies also found antimicrobial activities of preparations from the endocarp [70] and the mesocarp [71]. The antibacterial activities may be associated with phenolic compounds, terpenoids, phytosterols, and unsaturated fatty alcohols [67, 71], and their mechanism of action may involve perturbation of the bacterial cytoplasmic membrane [68].
Indications for antimycotic activity of C. nucifera were provided by the in vitro activity of an alcoholic extract of the shell against a wide diversity of fungal species [72]; that of the virgin oil from the coconut pulp and a teas from the husk fiber against Candida albicans [69, 73]; and that of coconut oil - either incorporated into a Viscogel tissue conditioner or not - against Candida albicans [74], a frequent cause of oral candidiasis and denture stomatitis. The antifungal activity has mainly been attributed to the presence of phenolic compounds in these preparations [72]. That C. nucifera may also exert antiviral activity is indicated by the inhibitory activity of a crude catechin-rich husk fiber extract against acyclovir-resistant herpes simplex virus type 1 [67] and the efficacy of coconut oil against a variety of viruses with lipid capsules such as visna virus, cytomegalovirus, and Epstein–Barr virus [75]. It has been suggested that the medium chain saturated fatty acids from coconut oil destroy and break the membranes and interfere with viral maturation [75]. Importantly, the apparent antiviral activity of C. nucifera may also account for the application of finely chewed coconut meat on shingles caused by herpes zoster infection [34].
The use of coconut meat against impurities in the face [34] and that of coconut oil for skin and hair care, skin lesions, sprains, and sore muscles [34] may mainly have its rationale in the analgesic and antiinflammatory properties of these parts of the plant. Support for an analgesic effect is provided by the inhibitory effects of orally administered husk fiber extracts as well as two aqueous subfractions derived therefrom on acetic acid-induced writhing, heat-induced tail flicking, and formalin-induced paw licking in mice [69, 76]. Comparable results were obtained with an ethanolic root extract that, in addition, potentiated the sleeping time of mice induced by pentobarbital sodium, diazepam, and meprobamate, potentiated analgesia induced by morphine and pethidine in the animals, and protected them from convulsions caused by pentylenetetrazole [77]. The latter action may also tentatively explain the putative protective effects of coconut oil in newborns against symptoms ascribed to the evil eye [33]. Administration of the opioid antagonist naloxone counteracted the antinociceptive effects of the C. nucifera preparations, indicating that they might act on opioid receptors [76]. Indications for antiinflammatory activity of the extracts were provided by their inhibitory effects on carrageenan carrageenan-, histamine-, and serotonin-induced paw edema and on cell migration, extravasation of protein, and TNF-α production following subcutaneous injection of air in rats [69, 76].
The usefulness of C. nucifera against diabetes mellitus [38] is supported by the decrease in fasting blood glucose and insulin levels as well as the restoration of all other biomarker as well as enzymes in streptozotocin- and alloxan-induced diabetic rats treated with a purified coconut kernel protein isolated from dried coconut kernel [78], a hydro-methanol or methanol extract of the immature inflorescence [79], or lyophilized mature coconut water [80]. The hypoglycemic effect of coconut water was comparable to that caused by glibenclamide [79, 80], and the antidiabetic activity of the purified coconut kernel protein has been attributed to the beneficial effects on pancreatic β cell regeneration of the relatively high levels of arginine in the protein [78]. And the traditional use in Suriname of a tea from the husk fibers to manage hypertension [38] is supported by the vasorelaxant activity of an ethanolic extract of the endocarp on isolated rat aortic rings and the blood pressure-lowering effect of the extract in deoxycorticosterone acetate salt-induced hypertensive rats [81]. This effect has been attributed to the direct activation of the nitric oxide/guanylate cyclase pathway as well as stimulation of muscarinic receptors and/or the cyclooxygenase (COX) pathway [81] and might be attributed to phenolic compounds in the extract [81].
4.4 Apocynaceae - Calotropis gigantea (L.) Dryand
The crown flower C. gigantea (Figure 8) called bidari or widuri in Surinamese-Javanese, is a fast-growing, evergreen, flowering shrub that can reach a height of 2 meters and that is native to Indonesia, India, southern China, and Malaysia. The vernacular name ‘crown flower’ is derived from the shape of the flower that consists of five pointed petals and a small crown-like structure rising from the center that holds the stamen. C. gigantea has extensively been cultivated in eastern Asian countries as an ornamental, for the fiber obtained from its stems, and for its medicinal uses, but easily naturalizes and is often found as a weed in uncultivated urban areas. It is an important religious plant in Hinduism where it is sacred to the God Shiva, and is used in various traditional medical systems throughout the world.
Figure 8.
The crown flower Calotropis gigantea (L.) Dryand (Apocynaceae) (from: https://images.app.goo.gl/AtQjN2XqM77NsXbo9).
C. gigantea has presumably been introduced in Suriname by Hindustani indentured laborers but its medicinal properties have also been recognized by other ethnic groups in the country including the Javanese. The milky latex is used to stop bleeding, and for treating minor wounds, boils, scabies, itches, bruises, cuts, sores, and burns [38]. The latex is also rubbed against the gums to ease toothache or put on a piece of gauze that is placed in a cavity to stop caries [38]. The dried stem is burned, placed in the nostrils, and the released vapors are inhaled for treating inflamed tonsils [36]. And preparations from the leaf are taken orally for severe chest colds and heart conditions [38].
Phytochemical studies showed a variety of bioactive compounds in various parts of the plant which may account for some of its pharmacological activities [82], providing support for some of the traditional uses. For instance, the milky latex and the leaf contain, among others, cardiac glycosides such as calotropin, gigantin and uscharin that exerted a digitalis-like action on the heart [83], possibly accounting for the traditional use of leaf preparations against heart conditions [38]. Another group of glycosides in the plant exhibited, along with certain flavonoids, phenolic compounds, and triterpenoids, antimicrobial and antioxidant properties [84] that may help explain the traditional use of the latex against a variety of skin lesions [38].
Further evidence to support the use of the plant to stop bleeding and treat various types of wounds [38] is provided by the apparent wound healing stimulating effects of the plant. For instance, the use of the latex led to a smaller wound area, faster epithelization, increased granuloma breaking strength, and improved wound contraction in excision and incision wounds in Wistar rats [85, 86]. And an ethanol extract of C. gigantea rootbark formulated as an ointment base for topical application, also stimulated the healing of incision, excision, and dead space wounds in albino rats, as judged by the increased percentage of wound contraction, the decreased degree of fibrosis, and the increased breaking strength [86].
The use of C. gigantea latex against toothache, caries, and chest colds [38], and that of the dried and burned stem against inflamed tonsils [36] is supported by the substantial inhibitory effects of aqueous and/or ethanolic extracts of the sap of the plant on the growth of various pathogenic bacteria as well as yeast species [87, 88]. Aqueous, methanol, ethanol, and petroleum ether extracts of the leaves of the plant also exerted broad antimicrobial activity against cultured bacterial strains [88], clinical isolates of Candida species [89], and the plant-pathogenic fungus Fusarium mangiferae that can cause serious damage to mango cultivations [90]. Additionally, a methanol extract from the rootbark and its petroleum ether, chloroform, and ethyl acetate fractions, as well as crude aqueous, ethanolic, and acetone extract also displayed broad in vitro antibacterial activity [89, 91].
Possibly contributing to the above-mentioned therapeutic efficacies of C. gigantea are the anti-inflammatory, antioxidant, analgesic, and antipyretic activities reported in various laboratory models. An ethanol extract of the leaf inhibited carrageenan-induced paw edema in Wistar albino rats to a greater extent than ibuprofen [92]; a hydroalcohlic leaf extract displayed notable DPPH radical-scavenging activity, reducing power activity, and nitric oxide scavenging activity [93]; an orally administered ethanolic extract of the flower produced a substantial decrease in the frequency of writhing and paw licking in laboratory rodents [94, 95]; and intraperitoneal administration of a water:ethanol extract of the root led to a reduction of the fever and normalization of the body temperature in yeast- and typhoid vaccine-induced pyrexia in Albino Swiss rats and rabbits [96].
5. Concluding remarks
The Javanese have been in Suriname for over a century. They have been brought to that country as poor and unaccustomed indentured laborers but have become successful individuals who have integrated well into the Surinamese community, actively participating in all its sections. Indeed, the Javanese are full-fledged citizens of the country and an integral part of the vibrant color palette represented by its unique cultural, religious, and ethnic diversity. This is reflected by the presence of the small, often family-owned Javanese restaurants called warungs in the smallest of towns, where widely appreciated savory dishes such as bami goreng (fried noodles), nasi goreng (fried rice), pityel (mixed blanched vegetables with a peanut sauce dressing), teloh (fried cassava), pejeh (prawn crackers), and saoto soup (chicken broth, meat, and vegetables) can be enjoyed, and can be washed down with refreshing beverages such as the lemongrass-, corn starch-, and coconut milk-based dawet.
Nevertheless, the Javanese have maintained most of their cultural traditions. This particularly holds true for their ancient form of medicine that is based on centuries-old Jamu. Jamu has added a unique element to the array of traditional forms of medicine throughout the Caribbean and Latin America, most of which are based on practices from the Indigenous American peoples as well as those from Africa, China, India, and various European countries. The influence of Jamu is already noticeable. The use of an infusion of the cat’s whiskers or kumis kutjing Orthosiphon aristatus (Blume) Miq. (Lamiaceae) for treating kidney stones and renal colics is no longer limited to Indonesia and Suriname but has expanded into many other parts of the world. It is foreseeable that many more Jamu recipes will one day contribute to Suriname’s traditional medicinal pharmacopeia as well as to the development of novel mainstream drugs for treating human diseases.
\n',keywords:"Suriname, Javanese, ethnopharmacology, medicinal plants, ethnobotanical uses, phytochemistry, pharmacology",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/76711.pdf",chapterXML:"https://mts.intechopen.com/source/xml/76711.xml",downloadPdfUrl:"/chapter/pdf-download/76711",previewPdfUrl:"/chapter/pdf-preview/76711",totalDownloads:189,totalViews:0,totalCrossrefCites:0,dateSubmitted:null,dateReviewed:"April 14th 2021",datePrePublished:"May 11th 2021",datePublished:"May 11th 2022",dateFinished:"May 11th 2021",readingETA:"0",abstract:"The Republic of Suriname (South America) is among the culturally, ethnically, and religiously most diverse countries in the world. Suriname’s population of about 600,000 consists of peoples from all continents including the Javanese who arrived in the country between 1890 and 1939 as indentured laborers to work on sugar cane plantations. After expiration of their five-year contract, some Javanese returned to Indonesia while others migrated to The Netherlands (the former colonial master of both Suriname and Indonesia), but many settled in Suriname. Today, the Javanese community of about 80,000 has been integrated well in Suriname but has preserved many of their traditions and rituals. This holds true for their language, religion, cultural expressions, and forms of entertainment. The Javanese have also maintained their traditional medical practices that are based on Jamu. Jamu has its origin in the Mataram Kingdom era in ancient Java, some 1300 years ago, and is mostly based on a variety of plant species. The many Jamu products are called jamus. The first part of this chapter presents a brief background of Suriname, addresses the history of the Surinamese Javanese as well as some of the religious and cultural expressions of this group, focuses on Jamu, and comprehensively deals with four medicinal plants that are commonly used by the Javanese. The second part of this chapter continues with an equally extensive narrative of six more such plants and concludes with a few remarks on the contribution of Javanese jamus to Suriname’s traditional medicinal pharmacopeia.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/76711",risUrl:"/chapter/ris/76711",signatures:"Dennis R.A. Mans, Priscilla Friperson, Meryll Djotaroeno and Jennifer Pawirodihardjo",book:{id:"11752",type:"book",title:"Natural Drugs from Plants",subtitle:null,fullTitle:"Natural Drugs from Plants",slug:"natural-drugs-from-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-80356-021-2",printIsbn:"978-1-80356-020-5",pdfIsbn:"978-1-80356-022-9",isAvailableForWebshopOrdering:!0,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"193905",title:"Dr.",name:"Dennis",middleName:"R. A.",surname:"R.A. Mans",fullName:"Dennis R.A. Mans",slug:"dennis-r.a.-mans",email:"dennismans16@gmail.com",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/193905/images/system/193905.png",institution:{name:"Anton de Kom University of Suriname",institutionURL:null,country:{name:"Suriname"}}},{id:"415841",title:"Dr.",name:"Priscilla",middleName:null,surname:"Friperson",fullName:"Priscilla Friperson",slug:"priscilla-friperson",email:"dummy+415841@intechopen.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"415842",title:"Dr.",name:"Meryll",middleName:null,surname:"Djotaroeno",fullName:"Meryll Djotaroeno",slug:"meryll-djotaroeno",email:"dummy+415842@intechopen.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"415843",title:"Dr.",name:"Jennifer",middleName:null,surname:"Pawirodihardjo",fullName:"Jennifer Pawirodihardjo",slug:"jennifer-pawirodihardjo",email:"dummy+415843@intechopen.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Background on Suriname",level:"1"},{id:"sec_2_2",title:"2.1 Geography, population, and economy",level:"2"},{id:"sec_3_2",title:"2.2 Brief history",level:"2"},{id:"sec_5",title:"3. Surinamese Javanese",level:"1"},{id:"sec_5_2",title:"3.1 The first arrivals",level:"2"},{id:"sec_6_2",title:"3.2 Javanese culture",level:"2"},{id:"sec_7_2",title:"3.3 Jamu",level:"2"},{id:"sec_9",title:"4. Plants used in Javanese pharmacognosy",level:"1"},{id:"sec_9_2",title:"4.1 Acanthaceae - Strobilanthes crispa Blume",level:"2"},{id:"sec_10_2",title:"4.2 Acoraceae - Acorus calamus L. 1753",level:"2"},{id:"sec_11_2",title:"4.3 Arecaceae - Cocos nucifera L.",level:"2"},{id:"sec_12_2",title:"4.4 Apocynaceae - Calotropis gigantea (L.) Dryand",level:"2"},{id:"sec_14",title:"5. Concluding remarks",level:"1"}],chapterReferences:[{id:"B1",body:'General Bureau of Statistics. Demographic data 2015-2018. 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Antifungal activity of the alcoholic extract of coconut shell - Cocos nucifera Linn. Journal of Ethnopharmacology. 1980;2:291-293. DOI: 10.1016/s0378-8741(80)81007-5.'},{id:"B73",body:'Borate PP, Disale SD, Ghalme RS. Studies on isolation, analysis and antimicrobial properties of coconut shell oil. International Journal of Advanced Scientific and Technological Research. 2013;2:146-157.'},{id:"B74",body:'Krishnamoorthy G, Narayana AI, Peralam PY, Balkrishanan D. To study the effect of Cocos nucifera oil when incorporated into tissue conditioner on its tensile strength and antifungal activity: An in vitro study. Journal of Indian Prosthodontic Society. 2019;19:225-232. DOI: 10.4103/jips.jips_387_18.'},{id:"B75",body:'Arora R, Chawla R, Marwah R, Arora P, Sharma RK, Kaushik V, et al. Potential of complementary and alternative medicine in preventive management of novel H1N1 flu (swine flu) pandemic: Thwarting potential disasters in the bud. Evidence-based Complementary and Alternative Medicine. 2011;586506. DOI: 10.1155/2011/586506.'},{id:"B76",body:'Rinaldi S, Silva DO, Bello F, Alviano CS, Alviano DS, Matheus ME, et al. Characterization of the antinociceptive and anti-inflammatory activities from Cocos nucifera L. (Palmae). Journal of Ethnopharmacology. 2009;122:541-546. DOI: 10.1016/j.jep.2009.01.024.'},{id:"B77",body:'Pal D, Sarkar A, Gain S, Jana S, Mandal S. CNS depressant activities of roots of Coccos nucifera in mice. Acta Poloniae Pharmaceutica. 2011;68:249-254.'},{id:"B78",body:'Salil G, Nevin KG, Rajamohan T. Argenine rich coconut kernel protein modulates in alloxan treated rats. Chemico-Biological Interactions. 2001;89:107-111.'},{id:"B79",body:'Naskar S, Mazumder UK, Pramanik G, Gupta M, Kumar RB, Bala A, et al. Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats. Journal of Ethnopharmacology. 2011;138:769-773. DOI: 10.1016/j.jep.2011.10.021.'},{id:"B80",body:'Preetha PP, Girija Devi V, Rajamohan T. Antihyperlipidemic effects of mature coconut water and its role in regulating lipid metabolism in alloxan-induced experimental diabetes. Comparative Clinical Pathology. 2013;23:1331-1337. DOI: 10.1007/s00580-013-1784-7.'},{id:"B81",body:'Bankar GR, Nayak PG, Bansal P, Paul P, Pai KS, Singla RK, et al. Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats. Journal of Ethnopharmacology. 2011;134:50-54. DOI: 10.1016/j.jep.2010.11.047.'},{id:"B82",body:'Shelar PA, Tikole S, Nalawade P, Gharge VG. Pharmacognostic and phytochemical evaluation of leaves of Calotropis gigantea. International Journal of Advanced Research. 2019;7:1361-1373.'},{id:"B83",body:'Koch V, Nieger M, Bräse S. Towards the synthesis of calotropin and related cardenolides from 3-epiandrosterone: A-ring related modifications. Organic Chemistry Frontiers. 2020;7:2670-2681. DOI: 10.1039/D0QO00269K.'},{id:"B84",body:'Saratha V, Subramanian S, Sivakumar. Evaluation of wound healing potential of Calotropis gigantea latex studied on excision wounds in experimental rats. Medicinal Chemistry Research. 2010;19:936-947. DOI: 10.1007/s00044-009-9240-6.'},{id:"B85",body:'Nalwaya N, Pokharna G, Deb L, Kumarjain N. Wound healing activity of latex of Calotropis gigantean. International Journal of Pharmacy and Pharmaceutical Sciences. 2009;1:176-181.'},{id:"B86",body:'Deshmukh PT, Fernandes J, Atul A, Toppo E. Wound healing activity of Calotropis gigantea root bark in rats. Journal of Ethnopharmacology. 2009;125:178-181. DOI: 10.1016/j.jep.2009.06.007.'},{id:"B87",body:'Kumar G, Karthik L, Bhaskara Rao KV (2010) Antimicrobial activity of latex of Calotropis gigantea against pathogenic microorganisms - An in vitro study. Pharmacology Online. 3: 155-163.'},{id:"B88",body:'Kori P, Alawa P (2014) Antimicrobial activity and phytochemical analysis of Calotropis gigantea root, latex extracts. IOSR Journal Of Pharmacy 4: 7-11.'},{id:"B89",body:'Kumar G, Karthik L, Bhaskara Rao KVB. In vitro anti-Candida activity of Calotropis gigantea against clinical isolates of Candida. J Pharm Res 2010;3:539-542.'},{id:"B90",body:'Usha K, Singh B, Praseetha P, Deepa N, Agarwal DK, Agarwal R, et al. Antifungal activity of Datura stramonium, Calotropis gigantea and Azadirachta indica against Fusarium mangiferae and floral malformation in mango European Journal of Plant Pathology. 2000;124:637-665.'},{id:"B91",body:'Alam MA, Habib MR, Nikkon R, Rahman M, Karim MR. Antimicrobial activity of akanda (Calotropis gigantea L.) on some pathogenic bacteria. Bangladesh Journal of Scientific and Industrial Research. 2008;43:397-404. DOI: 10.3329/bjsir.v43i3.1156.'},{id:"B92",body:'Das S, Das S, Das MK, Basu SP. Evaluation of anti-inflammatory effect of Calotropis gigantea and Tridax procumbens on Wistar albino rats. Journal of Pharmaceutical Sciences and Research. 2009;1:123-126.'},{id:"B93",body:'Singh N, Jain NK, Kannojia P, Garud N, Pathak AK, Mehta SC. In vitro antioxidant activity of Calotropis gigantea hydroalcohlic leaves extract. Der Pharmacia Lettre. 2010;2:95-100.'},{id:"B94",body:'Argal A, Pathak AK. CNS activity of Calotropis gigantea roots. Journal of Ethnopharmacology. 2006;106:142-145. DOI: 10.1016/j.jep.2005.12.024.'},{id:"B95",body:'Pathak AK, Argal A. Analgesic activity of Calotropis gigantea flower. Fitoterapia. 2007;78:40-42.'},{id:"B96",body:'Chitme HR, Chandra R, Kaushik S. Evaluation of antipyretic activity of Calotropis gigantean (Asclepiadaceae) in experimental animals. Phytotherapy Research. 2005;19:454-456. DOI: 10.1002/ptr.1672.'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Dennis R.A. Mans",address:"dennismans16@gmail.com",affiliation:'
Department of Pharmacology, Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, Suriname
Department of Pharmacology, Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, Suriname
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Her area of expertise is sustainable development. Prof. Djurovic was Deputy Prime Minister and Minister for European Integration in the Montenegrin Government (2004-2010) when she was the chief negotiator for SAA negotiation. She has authored twenty books and chapters in books related to sustainable economic development and the EU integration process and more than 70 scientific papers (https://www.ucg.ac.me/objava/blog/18163/objava/1). She is a Jean Monnet Professor, President of the Montenegrin Pan-European Union (MPEU), and member of the International PEU Presidency. 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Bojaj",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Montenegro",institutionURL:null,country:{name:"Montenegro"}}},{id:"315731",title:"Dr.",name:"Hopestone",surname:"Chavula",slug:"hopestone-chavula",fullName:"Hopestone Chavula",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"United Nations",institutionURL:null,country:{name:"United States of America"}}},{id:"319882",title:"Dr.",name:"Shaopeng",surname:"Zhong",slug:"shaopeng-zhong",fullName:"Shaopeng Zhong",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",institutionURL:null,country:{name:"China"}}},{id:"320374",title:"Ph.D.",name:"Claudio",surname:"Elórtegui-Gómez",slug:"claudio-elortegui-gomez",fullName:"Claudio Elórtegui-Gómez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"terms-and-conditions",title:"Terms and Conditions",intro:'
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Aminul Islam",coverURL:"https://cdn.intechopen.com/books/images_new/10440.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",middleName:null,surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10637",title:"Functional Foods",subtitle:"Phytochemicals and Health Promoting Potential",isOpenForSubmission:!1,hash:"a4aa0abf066e78deed1f65312ff24b22",slug:"functional-foods-phytochemicals-and-health-promoting-potential",bookSignature:"Muhammad Sajid Arshad and Muhammad Haseeb Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10637.jpg",editedByType:"Edited by",editors:[{id:"192998",title:"Dr.",name:"Muhammad Sajid",middleName:null,surname:"Arshad",slug:"muhammad-sajid-arshad",fullName:"Muhammad Sajid Arshad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8493",title:"Meat and Nutrition",subtitle:null,isOpenForSubmission:!1,hash:"fa7ad96f9b9e63093c9091fb0b93a5f4",slug:"meat-and-nutrition",bookSignature:"Chhabi Lal Ranabhat",coverURL:"https://cdn.intechopen.com/books/images_new/8493.jpg",editedByType:"Edited by",editors:[{id:"230681",title:"Dr.",name:"Chhabi Lal",middleName:null,surname:"Ranabhat",slug:"chhabi-lal-ranabhat",fullName:"Chhabi Lal Ranabhat"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8935",title:"Mineral Deficiencies",subtitle:"Electrolyte Disturbances, Genes, Diet and Disease Interface",isOpenForSubmission:!1,hash:"8bc7bd085801296d26c5ea58a7154de3",slug:"mineral-deficiencies-electrolyte-disturbances-genes-diet-and-disease-interface",bookSignature:"Gyula Mózsik and Gonzalo Díaz-Soto",coverURL:"https://cdn.intechopen.com/books/images_new/8935.jpg",editedByType:"Edited by",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9699",title:"Grain and Seed Proteins Functionality",subtitle:null,isOpenForSubmission:!1,hash:"9268519d1e294c5edf8e964a122e4c91",slug:"grain-and-seed-proteins-functionality",bookSignature:"Jose Carlos Jimenez-Lopez",coverURL:"https://cdn.intechopen.com/books/images_new/9699.jpg",editedByType:"Edited by",editors:[{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8472",title:"Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health",subtitle:null,isOpenForSubmission:!1,hash:"8855452919b8495810ef8e88641feb20",slug:"bioactive-compounds-in-nutraceutical-and-functional-food-for-good-human-health",bookSignature:"Kavita Sharma, Kanchan Mishra, Kula Kamal Senapati and Corina Danciu",coverURL:"https://cdn.intechopen.com/books/images_new/8472.jpg",editedByType:"Edited by",editors:[{id:"197731",title:"Dr.",name:"Kavita",middleName:null,surname:"Sharma",slug:"kavita-sharma",fullName:"Kavita Sharma"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:76,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"42000",doi:"10.5772/53159",title:"Valorisation of Cheese Whey, a By-Product from the Dairy Industry",slug:"valorisation-of-cheese-whey-a-by-product-from-the-dairy-industry",totalDownloads:7060,totalCrossrefCites:59,totalDimensionsCites:125,abstract:null,book:{id:"3424",slug:"food-industry",title:"Food Industry",fullTitle:"Food Industry"},signatures:"Chiara Mollea, Luca Marmo and Francesca Bosco",authors:[{id:"93865",title:"Dr.",name:"Francesca",middleName:null,surname:"Bosco",slug:"francesca-bosco",fullName:"Francesca Bosco"},{id:"96159",title:"Dr.",name:"Chiara",middleName:null,surname:"Mollea",slug:"chiara-mollea",fullName:"Chiara Mollea"},{id:"166295",title:"Prof.",name:"Luca",middleName:null,surname:"Marmo",slug:"luca-marmo",fullName:"Luca Marmo"}]},{id:"29151",doi:"10.5772/32358",title:"Hydrocolloids in Food Industry",slug:"hydrocolloids-in-food-industry",totalDownloads:30639,totalCrossrefCites:31,totalDimensionsCites:115,abstract:null,book:{id:"2082",slug:"food-industrial-processes-methods-and-equipment",title:"Food Industrial Processes",fullTitle:"Food Industrial Processes - Methods and Equipment"},signatures:"Jafar Milani and Gisoo Maleki",authors:[{id:"91158",title:"Associate Prof.",name:"Jafar",middleName:"Mohammadzadeh",surname:"Milani",slug:"jafar-milani",fullName:"Jafar Milani"},{id:"124058",title:"Ph.D. Student",name:"Gisoo",middleName:null,surname:"Maleki",slug:"gisoo-maleki",fullName:"Gisoo Maleki"}]},{id:"41694",doi:"10.5772/53172",title:"Seaweeds for Food and Industrial Applications",slug:"seaweeds-for-food-and-industrial-applications",totalDownloads:8325,totalCrossrefCites:34,totalDimensionsCites:100,abstract:null,book:{id:"3424",slug:"food-industry",title:"Food Industry",fullTitle:"Food Industry"},signatures:"Berna Kılınç, Semra Cirik, Gamze Turan, Hatice Tekogul and Edis Koru",authors:[{id:"88972",title:"Dr.",name:"Edis",middleName:null,surname:"Koru",slug:"edis-koru",fullName:"Edis Koru"},{id:"161688",title:"Dr.",name:"Berna",middleName:null,surname:"Kılınç",slug:"berna-kilinc",fullName:"Berna Kılınç"}]},{id:"40180",doi:"10.5772/50568",title:"Plant Tissue Culture: Current Status and Opportunities",slug:"plant-tissue-culture-current-status-and-opportunities",totalDownloads:66565,totalCrossrefCites:46,totalDimensionsCites:96,abstract:null,book:{id:"3568",slug:"recent-advances-in-plant-in-vitro-culture",title:"Recent Advances in Plant in vitro Culture",fullTitle:"Recent Advances in Plant in vitro Culture"},signatures:"Altaf Hussain, Iqbal Ahmed Qarshi, Hummera Nazir and Ikram Ullah",authors:[{id:"147617",title:"Dr.",name:"Altaf",middleName:null,surname:"Hussain",slug:"altaf-hussain",fullName:"Altaf Hussain"}]},{id:"53601",doi:"10.5772/66840",title:"Chitosan in Agriculture: A New Challenge for Managing Plant Disease",slug:"chitosan-in-agriculture-a-new-challenge-for-managing-plant-disease",totalDownloads:5738,totalCrossrefCites:33,totalDimensionsCites:72,abstract:"In recent years, environmental-friendly measures have been developed for managing crop diseases as alternative to chemical pesticides, including the use of natural compounds such as chitosan. In this chapter, the common uses of this natural product in agriculture and its potential uses in plant disease control are reviewed. The last advanced researches as seed coating, plant resistance elicitation and soil amendment applications are also described. Chitosan is a deacetylated derivative of chitin that is naturally present in the fungal cell wall and in crustacean shells from which it can be easily extracted. Chitosan has been reported to possess antifungal and antibacterial activity and it showed to be effective against seedborne pathogens when applied as seed treatment. It can form physical barriers (film) around the seed surface, and it can vehicular other antimicrobial compounds that could be added to the seed treatments. Chitosan behaves as a resistance elicitor inducing both local and systemic plant defence responses even when applied to the seeds. The chitosan used as soil amendment was shown to give many benefits to different plant species by reducing the pathogen attack and infection. Concluding, the chitosan is an active molecule that finds many possibilities for application in agriculture, including plant disease control.",book:{id:"5412",slug:"biological-activities-and-application-of-marine-polysaccharides",title:"Biological Activities and Application of Marine Polysaccharides",fullTitle:"Biological Activities and Application of Marine Polysaccharides"},signatures:"Laura Orzali, Beatrice Corsi, Cinzia Forni and Luca Riccioni",authors:[{id:"189361",title:"Ph.D.",name:"Laura",middleName:null,surname:"Orzali",slug:"laura-orzali",fullName:"Laura Orzali"},{id:"189612",title:"Dr.",name:"Luca",middleName:null,surname:"Riccioni",slug:"luca-riccioni",fullName:"Luca Riccioni"},{id:"189614",title:"Dr.",name:"Beatrice",middleName:null,surname:"Corsi",slug:"beatrice-corsi",fullName:"Beatrice Corsi"},{id:"189615",title:"Prof.",name:"Cinzia",middleName:null,surname:"Forni",slug:"cinzia-forni",fullName:"Cinzia Forni"}]}],mostDownloadedChaptersLast30Days:[{id:"64570",title:"Banana Pseudo-Stem Fiber: Preparation, Characteristics, and Applications",slug:"banana-pseudo-stem-fiber-preparation-characteristics-and-applications",totalDownloads:9543,totalCrossrefCites:16,totalDimensionsCites:20,abstract:"Banana is one of the most well-known and useful plants in the world. Almost all the parts of this plant, that are, fruit, leaves, flower bud, trunk, and pseudo-stem, can be utilized. This chapter deals with the fiber extracted from the pseudo-stem of the banana plant. It discusses the production of banana pseudo-stem fiber, which includes plantation and harvesting; extraction of banana pseudo-stem fiber; retting; and degumming of the fiber. It also deals with the characteristics of the banana pseudo-stem fiber, such as morphological, physical and mechanical, durability, degradability, thermal, chemical, and antibacterial properties. Several potential applications of this fiber are also mentioned, such as the use of this fiber to fabricate rope, place mats, paper cardboard, string thread, tea bags, high-quality textile materials, absorbent, polymer/fiber composites, etc.",book:{id:"7544",slug:"banana-nutrition-function-and-processing-kinetics",title:"Banana Nutrition",fullTitle:"Banana Nutrition - Function and Processing Kinetics"},signatures:"Asmanto Subagyo and Achmad Chafidz",authors:[{id:"257742",title:"M.Sc.",name:"Achmad",middleName:null,surname:"Chafidz",slug:"achmad-chafidz",fullName:"Achmad Chafidz"},{id:"268400",title:"Mr.",name:"Asmanto",middleName:null,surname:"Subagyo",slug:"asmanto-subagyo",fullName:"Asmanto Subagyo"}]},{id:"40180",title:"Plant Tissue Culture: Current Status and Opportunities",slug:"plant-tissue-culture-current-status-and-opportunities",totalDownloads:66561,totalCrossrefCites:45,totalDimensionsCites:96,abstract:null,book:{id:"3568",slug:"recent-advances-in-plant-in-vitro-culture",title:"Recent Advances in Plant in vitro Culture",fullTitle:"Recent Advances in Plant in vitro Culture"},signatures:"Altaf Hussain, Iqbal Ahmed Qarshi, Hummera Nazir and Ikram Ullah",authors:[{id:"147617",title:"Dr.",name:"Altaf",middleName:null,surname:"Hussain",slug:"altaf-hussain",fullName:"Altaf Hussain"}]},{id:"68437",title:"Chemical Properties of Starch and Its Application in the Food Industry",slug:"chemical-properties-of-starch-and-its-application-in-the-food-industry",totalDownloads:4815,totalCrossrefCites:19,totalDimensionsCites:50,abstract:"Starch is an important food product and a versatile biomaterial used world-wide for different purposes in many industrial sectors including foods, health, textile, chemical and engineering sector. Starch versatility in industrial applications is largely defined by its physicochemical properties and functionality. Starch in its native form has limited functionality and application. But advancements in biotechnology and chemical technological have led to wide-range modification of starch for different purposes. The objective of this chapter is to examine the different chemical reactions of starch and expose the food applications of the modification products. Several literatures on starch and reaction chemistry including online journals and books were analyzed, harmonized and rationalized. The reactions and mechanisms presented are explained based on the principles of reaction chemistry. Chemical modification of starch is based on the chemical reactivity of the constituent glucose monomers which are polyhydroxyl and can undergo several reactions. Starch can undergo reactions such as hydrolysis, esterification, etherification and oxidation. These reactions give modified starches which can be used in baked foods, confectionaries, soups and salad dressings. This chapter discusses the different chemical reactions of starch, the associated changes in functionality, as well as the applications of chemically modified starches in the food industry.",book:{id:"8170",slug:"chemical-properties-of-starch",title:"Chemical Properties of Starch",fullTitle:"Chemical Properties of Starch"},signatures:"Henry Omoregie Egharevba",authors:[{id:"300976",title:"Associate Prof.",name:"Henry",middleName:"Omoregie",surname:"O. Egharevba",slug:"henry-o.-egharevba",fullName:"Henry O. Egharevba"}]},{id:"63169",title:"The Dairy Industry: Process, Monitoring, Standards, and Quality",slug:"the-dairy-industry-process-monitoring-standards-and-quality",totalDownloads:9180,totalCrossrefCites:12,totalDimensionsCites:29,abstract:"Sampling and analysis occur along the milk processing train: from collection at farm level, to intake at the diary plant, the processing steps, and the end products. Milk has a short shelf life; however, products such as milk powders have allowed a global industry to be developed. Quality control tests are vital to support activities for hygiene and food standards to meet regulatory and customer demands. Multiples of chemical and microbiological contamination tests are undertaken. Hazard analysis testing strategies are necessary, but some tests may be redundant; it is therefore vital to identify product optimization quality control strategies. The time taken to undergo testing and turnaround time are rarely measured. The dairy industry is a traditional industry with a low margin commodity. Industry 4.0 vision for dairy manufacturing is to introduce the aspects of operational excellence and implementation of information and communications technologies. The dairy industries’ reply to Industry 4.0 is represented predominantly by proactive maintenance and optimization of production and logistical chains, such as robotic milking machines and processing and packaging line automation reinforced by sensors for rapid chemical and microbial analysis with improved and real-time data management. This chapter reviews the processing trains with suggestions for improved optimization.",book:{id:"6817",slug:"descriptive-food-science",title:"Descriptive Food Science",fullTitle:"Descriptive Food Science"},signatures:"Niamh Burke, Krzysztof A. Zacharski, Mark Southern, Paul Hogan,\nMichael P. Ryan and Catherine C. Adley",authors:[{id:"243276",title:"Dr.",name:"Michael P",middleName:null,surname:"Ryan",slug:"michael-p-ryan",fullName:"Michael P Ryan"},{id:"246153",title:"Prof.",name:"Catherine",middleName:null,surname:"Adley",slug:"catherine-adley",fullName:"Catherine Adley"},{id:"264302",title:"Ms.",name:"Niamh",middleName:null,surname:"Burke",slug:"niamh-burke",fullName:"Niamh Burke"},{id:"264304",title:"Mr.",name:"Krzysztof A",middleName:null,surname:"Zacharski",slug:"krzysztof-a-zacharski",fullName:"Krzysztof A Zacharski"},{id:"264305",title:"Mr.",name:"Paul",middleName:null,surname:"Hogan",slug:"paul-hogan",fullName:"Paul Hogan"},{id:"264306",title:"Dr.",name:"Mark",middleName:null,surname:"Southern",slug:"mark-southern",fullName:"Mark Southern"}]},{id:"40181",title:"Plant Tissue Culture Media",slug:"plant-tissue-culture-media",totalDownloads:105096,totalCrossrefCites:9,totalDimensionsCites:34,abstract:null,book:{id:"3568",slug:"recent-advances-in-plant-in-vitro-culture",title:"Recent Advances in Plant in vitro Culture",fullTitle:"Recent Advances in Plant in vitro Culture"},signatures:"Abobkar I.M. Saad and Ahmed M. Elshahed",authors:[{id:"144204",title:"Prof.",name:"Abobkar",middleName:null,surname:"Mohamed",slug:"abobkar-mohamed",fullName:"Abobkar Mohamed"}]}],onlineFirstChaptersFilter:{topicId:"33",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81786",title:"Mycotoxins … Silent Death",slug:"mycotoxins-silent-death",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.104382",abstract:"There are many types of fungi that produce secondary metabolites called mycotoxins. These compounds are very dangerous to humans and animals, as exposure to them causes acute or chronic toxicity. Temperature, humidity and pH are important environmental factors in the production of mycotoxins. There are about 500 types of mycotoxins that are found in many agricultural products such as peanut, cereals, wines, fruit juice, dried fruits, feed, and other foodstuffs. Among the most important genera of fungi that produce mycotoxins are Aspergillus, Penicillium, Altenaria, Fusarium, and others. Some of them infect plants in the field and produce mycotoxin, while others infect agricultural crops, foodstuffs, and feed in the store and produce mycotoxin during storage conditions. Mycotoxins are divided into various groups according to the degree of their impact and danger, into highly toxic, low toxic, carcinogenic, and mutagenic. This is depends on the chemical composition of the different types of mycotoxins, which are an open hydrocarbon chain with low molecular weights ranging between 100 and 697 Da. The biological effects of mycotoxins include damage to living tissues, suppression of immunity, and neurological disorders. Aflatoxins are one of the most dangerous mycotoxins as they are the main cause of hepatocellular carcinoma and the fifth most common carcinogen in the world.",book:{id:"11023",title:"Mycotoxins and Food Safety - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11023.jpg"},signatures:"Azhar A. Alhaddad"},{id:"81871",title:"The Influence of Some Contaminants in Food Quality",slug:"the-influence-of-some-contaminants-in-food-quality",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.102911",abstract:"The concept of food quality has been following scientific and technological evolution. Currently, producers, users, consumers, as well as public authorities, have well defined their expectations regarding the quality requirements in the food sector. These projections are related to several parameters that are no longer seen only from a safety and nutritional point of view. Thus, the characteristics of food products must fulfill criteria that embrace their origin, esthetics, convenience, functionality, ethics, organoleptic and must result in benefit. The needs of consumers increasingly reflect public interests, which are supervised by public authorities that hold technical and scientific information that allows them to advocate normative regulations regarding defects, adulteration, and fraud, increasing awareness in the food quality field. Since food quality and safety are two increasingly interconnected domains, the different EU legislation and regulations impose procedures for the determination of contaminants. In this chapter, we will only cover three main topics, namely heavy metals, polycyclic aromatic hydrocarbons, and mycotoxins.",book:{id:"11023",title:"Mycotoxins and Food Safety - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11023.jpg"},signatures:"Marisa Nicolai, Paula Pereira and Lídia Palma"},{id:"80942",title:"Mycotoxin Decontamination of Foods Using Nonthermal Plasma and Plasma-Activated Water",slug:"mycotoxin-decontamination-of-foods-using-nonthermal-plasma-and-plasma-activated-water",totalDownloads:54,totalDimensionsCites:1,doi:"10.5772/intechopen.103779",abstract:"Mycotoxins are food safety and public health concerns due to their widespread contamination in agricultural products and adverse health effects on humans. Several decontamination techniques, including physical-, chemical-, and thermal-based treatments, are employed to minimize the levels of mycotoxins in food. However, these treatments present disadvantages, such as negative impacts on the quality and leftover chemical residues on the treated food after physical- and chemical-based treatments. Furthermore, mycotoxins are resistant to heat, thus contributing to the insufficiency of thermal treatments for complete mycotoxin degradation. The use of alternative nonthermal-based treatments, such as nonthermal plasma (NTP) and plasma-activated water (PAW) for mycotoxin degradation in food, have been recently explored to overcome these limitations. NTP and PAW treatments are known to minimize the unfavorable changes in food quality while ensuring safety from food contaminants. The basics of NTP and PAW technologies, their mycotoxin decontamination efficiencies, their underlying mechanisms of action, effects on food quality, and the safety of mycotoxin degradation byproducts and treated food are hereby discussed in this chapter.",book:{id:"11023",title:"Mycotoxins and Food Safety - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11023.jpg"},signatures:"Hsiu-Ling Chen, Rachelle D. Arcega, Samuel Herianto, Chih-Yao Hou and Chia-Min Lin"},{id:"80268",title:"Animal Feeds Mycotoxins and Risk Management",slug:"animal-feeds-mycotoxins-and-risk-management",totalDownloads:75,totalDimensionsCites:0,doi:"10.5772/intechopen.102010",abstract:"The demand for livestock products is the main factor affecting the demand for livestock feeds worldwide. However, animal feed safety has gradually become more important, with mycotoxins representing one of the most significant hazards. Mycotoxins are toxic secondary metabolites produced naturally by fungi that grow on various agriculture commodities. Aflatoxin, fumonisin, ochratoxin, trichothecene, and zearalenone are the more prevalent mycotoxins in animal feeds. Some of mycotoxins impacts include; loss of animal and human health, reduced animal productivity, increased veterinary service costs, feed disposal and increased research costs which enhance the importance of mycotoxins detoxification. Contamination of feeds may occur both during pre-harvest and post-harvest. The purpose of this chapter is to review the most prevalent mycotoxins in animal feeds, reveal the origin of mycotoxins contamination and the possible risks they pose to feeds and livestock. This chapter also gives an overview of the most important factors that influence mold growth and mycotoxin production as well as the economic impacts of mycotoxins. To the end of this chapter, mycotoxins preventive methods, both preharvest and postharvest, are well discussed.",book:{id:"11023",title:"Mycotoxins and Food Safety - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11023.jpg"},signatures:"Zacharia Waithaka Ng’ang’a and Eric Niyonshuti"},{id:"80725",title:"Implications of Mycotoxins in Food Safety",slug:"implications-of-mycotoxins-in-food-safety",totalDownloads:77,totalDimensionsCites:0,doi:"10.5772/intechopen.102495",abstract:"The chapter aims to address an overview of the implications of mycotoxins in food safety and the presence of mycotoxins in various foods. Nowadays, everyone wants safe food with a long shelf life. Food safety has become a major strategic issue worldwide and has attracted worldwide attention. Mycotoxins are widely found in food and feed, and dietary exposure to them can induce various types of adverse health effects in humans and animals. Contamination of food by fungi and mycotoxins results in loss of dry matter, quality and nutrition, and poses a significant danger to the food chain. Moreover, mycotoxin contamination decreases product quality and reduces export values, which can lead to significant economic losses for producing countries. Mycotoxin contamination directly reduces food availability and has its own contribution to hunger and malnutrition, and the consumption of food contaminated with mycotoxins has major repercussions on human health.",book:{id:"11023",title:"Mycotoxins and Food Safety - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11023.jpg"},signatures:"Romina Alina Marc"},{id:"79582",title:"Cunninghamella bertholletiae’s Toxins from Decomposing Cassava: Mitigation Strategy for Toxin Reduction Using Nepenthes mirabilis ‘Monkey Cup’ Digestive Fluids",slug:"cunninghamella-bertholletiae-s-toxins-from-decomposing-cassava-mitigation-strategy-for-toxin-reducti",totalDownloads:94,totalDimensionsCites:0,doi:"10.5772/intechopen.101353",abstract:"A fermentation technique was utilised to assess a fungus, i.e. Cunninghamella bertholletiae/polymorpha, isolated from rotting cassava, ability to produce mycotoxins and resultant oxidation by-products of the mycotoxins using liquid chromatography–mass spectrometry (LC/MS). Thus, the mycotoxins/secondary metabolites, fumonisin B1 (FB1) and deoxynivalenol (DON) were produced while, heptadecanone, octadecanamide, octadecenal and 3-keto-deoxynivalenol (DON) were successfully identified as biodegradation by-products in the fermentation broth treated with hydrolysing ‘monkey cup’ juice from Nepenthes mirabilis. Exposure to the mycotoxins and the biodegradation by-products through consumption of contaminated produce including contact due to the cumulative presence in arable agricultural soil can be harmful to humans and animals. Therefore, this work reports on a strategy for the mitigation and reduction of mycotoxins in agricultural soil using natural plant pitcher juices from N. mirabilis’ ‘monkey cup’.",book:{id:"11023",title:"Mycotoxins and Food Safety - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11023.jpg"},signatures:"Elie Fereche Itoba-Tombo, Seteno Karabo Obed Ntwampe, John Baptist Nzukizi Mudumbi, Lukhanyo Mekuto, Enoch Akinbiyi Akinpelu and Nkosikho Dlangamandla"}],onlineFirstChaptersTotal:7},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:"2753-6580",scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
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\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo, Ph.D., is a professor in the Department of Engineering, University of Naples “Parthenope,” Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino and Southern Lazio, Italy. Her research interests include multi-criteria decision analysis, industrial plants, logistics, manufacturing, and safety. She serves as an associate editor for the International Journal of the Analytic Hierarchy Process and is an editorial board member for several other journals. She is also a member of the Analytic Hierarchy Process (AHP) Academy.",institutionString:"Parthenope University of Naples",institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",isOpenForSubmission:!0,editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",isOpenForSubmission:!0,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:"Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the 'new normal'. Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!0,editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. Current research interests include trophic flows across ecosystems; watershed impacts of land-use change on biodiversity and ecosystem functioning; ecological civilization and water resource management; urban ecology and urban/rural sustainable development.",institutionString:null,institution:{name:"Soochow University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",isOpenForSubmission:!0,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. 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She is a member of the Coordination and Scientific Committees of the doctoral program “Tropical Knowledge and Management” (NOVA), Master in Biotechnology (UEM), and Master in Conservation Biology (GNP); and a national expert for Food and Nutrition Security and Sustainable Agriculture - High-Level Policy Dialogue EU-Africa. 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\r\n\tThe Business and Management series topic focuses on the most pressing issues confronting organizations today and in the future. Businesses are trying to figure out how to lead in a time of global uncertainty. In emerging markets, issues such as ill-defined or unstable policies, as well as corrupt practices, can be hugely problematic. Changes in governments can result in new policy, regulations, and interest rates, all of which can be detrimental to foreign businesses and investments. A growing trend towards economic nationalism also makes the current global political landscape potentially hostile towards international businesses.
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\r\n\tThe demographic shifts are creating interesting challenges. People are living longer, resulting to an aging demographic. We have a large population of older workers and retirees who are living longer lives, combined with a declining birthrate in most parts of the world. Businesses of all types are looking at how technology is affecting their operations. Several questions arise, such as: How is technology changing what we do? How is it transforming us internally, how is it influencing our clients and our business strategy? It is about leveraging technology to improve efficiency, connect with customers more effectively, and drive innovation. The majority of innovative companies are technology-driven businesses. Realizing digital transformation is today’s top issue and will remain so for the next five years. Improving organizational agility, expanding portfolios of products and services, creating, and maintaining a culture of innovation, and developing next -generation leaders were also identified as top challenges in terms of both current and future issues.
\r\n
\r\n\tThe most sustained profitable growth occurs when a company expands its core business into an adjacent space. This has significant implications for management because innovation in business ecosystems differs from traditional, vertically integrated firms. Every organization in the ecosystem must be aware of the bigger picture. Innovation in ecosystems necessitates collaborative action to invent and appraise, efficient, cross-organizational knowledge flows, modular architectures, and good stewardship of legacy systems. It is built on multiple, interconnected platforms. Environmental factors have already had a significant impact in the West and will continue to have an impact globally. Businesses must take into account the environmental impact of their daily operations. The advantage of this market is that it is expected to grow more rapidly than the overall economy. Another significant challenge is preparing the next generation of leaders to elevate this to the number one priority within the next five years. There can be no culture of innovation unless there is diverse leadership or development of the next generation of leaders; and these diverse, next-generation leaders are the ones who will truly understand the digital strategies that will drive digital transformation.
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