Processing times, total detections, and false positives for each face detection algorithm.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"7110",leadTitle:null,fullTitle:"Opioids - From Analgesic Use to Addiction",title:"Opioids",subtitle:"From Analgesic Use to Addiction",reviewType:"peer-reviewed",abstract:"Morphine and other opioids are potent analgesic drugs, but their use can lead to complications. Being familiar with the use of this kind of drug can make the difference between obtaining the expected benefit of applied therapy or magnifying the risks to intolerable levels for the patient. Therefore, it is essential for practitioners to achieve adequate training in the management of these drugs based on criteria endorsed by scientific evidence that allows the proper use of these drugs and guarantees the best professional practice every time. Written by expert authors in the field, the purpose of this book is to offer an overview of opioid drugs, from their therapeutic use to the consequences associated.",isbn:"978-1-83880-953-9",printIsbn:"978-1-83880-958-4",pdfIsbn:"978-1-83880-954-6",doi:"10.5772/intechopen.73905",price:119,priceEur:129,priceUsd:155,slug:"opioids-from-analgesic-use-to-addiction",numberOfPages:106,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"8bd70b93e5c8ff9ea766159555eb63da",bookSignature:"Pilar Almela Rojo",publishedDate:"June 10th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/7110.jpg",numberOfDownloads:5373,numberOfWosCitations:0,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:7,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 23rd 2018",dateEndSecondStepPublish:"July 31st 2018",dateEndThirdStepPublish:"September 29th 2018",dateEndFourthStepPublish:"December 18th 2018",dateEndFifthStepPublish:"February 16th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"98258",title:"Dr.",name:"Pilar",middleName:null,surname:"Almela Rojo",slug:"pilar-almela-rojo",fullName:"Pilar Almela Rojo",profilePictureURL:"https://mts.intechopen.com/storage/users/98258/images/system/98258.png",biography:"After completing her studies in Pharmacy at the University of Granada, Pilar Almela joined a PhD program in Experimental Biomedical Sciences at the University of Murcia in the Department of Pharmacology, under Professor Laorden’s supervision, where she studied different pathway involvement in the adaptive changes observed during morphine dependence. Her training was completed with stays at research centers in USA, France, United Kingdom and Spain.\nResults from her laboratory have given rise to numerous international publications. These findings can improve the knowledge of mechanisms involved in addiction and establish new prevention and treatment strategies.\nIn 2019, she became an Associate Professor at the Department of Pharmacology, focusing her current research on the design of new nanoparticulate systems for morphine administration.",institutionString:"University of Murcia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Murcia",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1197",title:"Pharmaceutical Drug",slug:"pharmaceutical-drug"}],chapters:[{id:"72068",title:"Introductory Chapter: Opioid Analgesics - History, Uses and Risks",doi:"10.5772/intechopen.92401",slug:"introductory-chapter-opioid-analgesics-history-uses-and-risks",totalDownloads:872,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Pilar Almela",downloadPdfUrl:"/chapter/pdf-download/72068",previewPdfUrl:"/chapter/pdf-preview/72068",authors:[{id:"98258",title:"Dr.",name:"Pilar",surname:"Almela Rojo",slug:"pilar-almela-rojo",fullName:"Pilar Almela Rojo"}],corrections:null},{id:"66275",title:"A New Paradigm: Prevention of Central Sensitization in Pain Management through Minimizing Opioid Exposure",doi:"10.5772/intechopen.85192",slug:"a-new-paradigm-prevention-of-central-sensitization-in-pain-management-through-minimizing-opioid-expo",totalDownloads:864,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Current exacerbations of chronic pain cannot be understood in isolation from how past incidents impact pain and its experience. Patients who frequent the Emergency Room or hospital for a pain crisis or intensification of their pain without new findings on X-rays or scans are often seen as ‘drug seekers.’ Yet, to the patient the pain is agonizing, and the suffering real. It is this type of patient that prompted an ongoing improvement project in our local hospital, our Multiple Visit Patient Complex Care Program. The goal was to determine the similarities between this type of ‘complex’ patient—who frequents the hospital despite no new radiographic change—and other patients. Understanding this ‘complex’ pattern in terms of central intractable pain can change the trajectory of treatment. Results of our program described here reveal that a better understanding of central pain and central sensitization can result in better patient care.",signatures:"Pamela Bolyanatz",downloadPdfUrl:"/chapter/pdf-download/66275",previewPdfUrl:"/chapter/pdf-preview/66275",authors:[{id:"269060",title:"Mrs.",name:"Pamela",surname:"Bolyanatz",slug:"pamela-bolyanatz",fullName:"Pamela Bolyanatz"}],corrections:null},{id:"69169",title:"Other Uses of Morphine",doi:"10.5772/intechopen.85165",slug:"other-uses-of-morphine",totalDownloads:857,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Worldwide many different strong opioids and their formulations are available to control pain. Of which, morphine is considered as global opioid of choice and is widely used to control moderate to severe pain. The World Health Organization (WHO) has recommended morphine as one of the essential drug. Apart from analgesic use, research has proven its effectiveness for relief and treatment of various debilitating and distressing conditions like breathlessness, mucositis (oral and vaginal) and cough. However, its role in diarrhea and opioid substitution therapy (OST) is still nonconfirmatory. This chapter illustrates all available literature supporting effectiveness of morphine in above conditions and its impact on quality of life.",signatures:"Shrenik Ostwal",downloadPdfUrl:"/chapter/pdf-download/69169",previewPdfUrl:"/chapter/pdf-preview/69169",authors:[{id:"267116",title:"Dr.",name:"Shrenik",surname:"Ostwal",slug:"shrenik-ostwal",fullName:"Shrenik Ostwal"}],corrections:null},{id:"70790",title:"Role of Glucocorticoid Receptor in the Relation between Stress and Opiate Addiction",doi:"10.5772/intechopen.90839",slug:"role-of-glucocorticoid-receptor-in-the-relation-between-stress-and-opiate-addiction",totalDownloads:694,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Stressful situations can result in relapse in dependent or abstinent causing reinstatement of drug-seeking. In fact, it has been suggested that activation of the brain stress system results in glucocorticoid release that affects the dopaminergic pathways. Also, the noradrenergic system innervates the extrahypothalamic BSS from the nucleus of tractus solitarius (NTS), resulting in a feedforward loop between the corticotropin-releasing factor (CRF) and noradrenaline (NA) crucial in drug addiction and relapses. Glucocorticoids interact with two receptors: mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) which bind to a GRE site located in tyrosine hydroxylase (TH), resulting in the upregulation of TH synthesis and, finally, increasing dopamine (DA) release in the nucleus accumbens. TH upregulation depends on the phosphorylation of serine 31 and/or serine 40. Previous research has shown that protein kinase C (PKC) activates extracellular signal-regulated kinase (ERK) pathway and in turn phosphorylates serine 31 in the NTS. Besides, cAMP response element binding protein (CREB) is regulated by PKA and PKC. The results shown after pretreating morphine-withdrawn rats with mifepristone and spironolactone (GR and MR antagonists, respectively) suggest that glucocorticoids have a prominent role in addiction because GR would activate ERK and CREB in the NTS, phosphorylating serine 31 and activating TH and indeed noradrenergic release in the paraventricular nucleus (PVN).",signatures:"Javier Navarro-Zaragoza, María Victoria Milanés and María Luisa Laorden",downloadPdfUrl:"/chapter/pdf-download/70790",previewPdfUrl:"/chapter/pdf-preview/70790",authors:[{id:"98255",title:"Prof.",name:"M. Luisa",surname:"Laorden",slug:"m.-luisa-laorden",fullName:"M. Luisa Laorden"},{id:"255965",title:"Dr.",name:"Javier",surname:"Navarro-Zaragoza",slug:"javier-navarro-zaragoza",fullName:"Javier Navarro-Zaragoza"},{id:"314578",title:"Prof.",name:"M. Victoria",surname:"Milanés",slug:"m.-victoria-milanes",fullName:"M. Victoria Milanés"}],corrections:null},{id:"63223",title:"Corticotrophin-Releasing Factor (CRF) through CRF1 Receptor Facilitates the Expression of Morphine-Related Positive and Aversive Memory in Mice",doi:"10.5772/intechopen.80504",slug:"corticotrophin-releasing-factor-crf-through-crf1-receptor-facilitates-the-expression-of-morphine-rel",totalDownloads:969,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Different studies have elucidated the mechanisms underlying the formation and expression of drug-related cue memories; corticotrophin-releasing factor (CRF) plays a critical role in reward- and aversion-driven associative learning. In the present chapter, we have evaluated whether CP-154,526, a selective CRF1 receptor (CRF1R) antagonist, or genetic deletion of CRF1R (KO mice) have comparable effects on conditioned place preference (CPP) and conditioned place aversion (CPA) learning. We also investigated CP-154,526 effects on morphine-induced CPP activation of CRF, CREB phosphorylation, and thioredoxin (Trx1) expression in dentate gyrus (DG), a brain region involved in memory consolidation, and the role of hypothalamic-pituitary-adrenocortical (HPA) axis in CPA expression and extinction. The CRF1R antagonist abolished the acquisition of morphine CPP, Trx-1 and BDNF increased expression, and pCREB/Trx-1 co-localization in the DG. The increase in adrenocorticotropic hormone (ACTH) plasma levels observed after CPA expression was attenuated in CRF1R KO mice, suggesting a role of HPA axis in aversive memories. Altogether, these results suggest a critical role of CRF, through CRF1R, in molecular changes involved in memory formation and consolidation and may facilitate the development of effective treatments for opioid addiction.",signatures:"Pilar Almela, Juan A. García-Carmona, Elena Martínez-Laorden, María V. Milanés and María L. Laorden",downloadPdfUrl:"/chapter/pdf-download/63223",previewPdfUrl:"/chapter/pdf-preview/63223",authors:[{id:"98258",title:"Dr.",name:"Pilar",surname:"Almela Rojo",slug:"pilar-almela-rojo",fullName:"Pilar Almela Rojo"},{id:"98255",title:"Prof.",name:"M. Luisa",surname:"Laorden",slug:"m.-luisa-laorden",fullName:"M. Luisa Laorden"},{id:"210633",title:"Dr.",name:"Juan Antonio",surname:"García-Carmona",slug:"juan-antonio-garcia-carmona",fullName:"Juan Antonio García-Carmona"},{id:"210634",title:"Dr.",name:"Elena",surname:"Martínez-Laorden",slug:"elena-martinez-laorden",fullName:"Elena Martínez-Laorden"},{id:"210635",title:"Prof.",name:"María Victoria",surname:"Milanés",slug:"maria-victoria-milanes",fullName:"María Victoria Milanés"}],corrections:null},{id:"65505",title:"Present and Future Pharmacological Treatments for Opioid Addiction",doi:"10.5772/intechopen.82443",slug:"present-and-future-pharmacological-treatments-for-opioid-addiction",totalDownloads:1118,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"When treating opioid addiction, multidisciplinary treatment is highly recommended, but pharmacotherapy plays a key role. Although the ideal goal is to achieve complete abstinence, an elevated percentage of opioid addicts requires maintenance substitution therapy. In the first section of this chapter, we will focus on the current pharmacological interventions to treat opioid addiction, such as methadone, buprenorphine, and naltrexone. Thanks to these medications, people are able to go back to their normal lives, by preventing withdrawal symptoms, reducing craving, and increasing their adherence to psychotherapy. In the second section, based on the evidence that addiction induces neuroadaptive changes in several neurotransmission systems, we focus on the wide range of possible pharmacological developments at the preclinical and clinical levels, which in recent years have increased considerably.",signatures:"Maria Carmen Blanco-Gandía, Sandra Montagud-Romero and Marta Rodríguez-Arias",downloadPdfUrl:"/chapter/pdf-download/65505",previewPdfUrl:"/chapter/pdf-preview/65505",authors:[{id:"101721",title:"Dr.",name:"Marta",surname:"Rodriguez-Arias",slug:"marta-rodriguez-arias",fullName:"Marta Rodriguez-Arias"},{id:"260048",title:"Dr.",name:"M Carmen",surname:"Blanco-Gandia",slug:"m-carmen-blanco-gandia",fullName:"M Carmen Blanco-Gandia"},{id:"260049",title:"Dr.",name:"Sandra",surname:"Montagud-Romero",slug:"sandra-montagud-romero",fullName:"Sandra Montagud-Romero"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"2509",title:"Recent Advances in Novel Drug Carrier Systems",subtitle:null,isOpenForSubmission:!1,hash:"57c10c8e0b4bb01a815f2c42db01956e",slug:"recent-advances-in-novel-drug-carrier-systems",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/2509.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5525",title:"Pain Relief",subtitle:"From Analgesics to Alternative Therapies",isOpenForSubmission:!1,hash:"5ffdba8a1f402fe1b279cf05e2fa0aae",slug:"pain-relief-from-analgesics-to-alternative-therapies",bookSignature:"Cecilia Maldonado",coverURL:"https://cdn.intechopen.com/books/images_new/5525.jpg",editedByType:"Edited by",editors:[{id:"73432",title:"Dr.",name:"Cecilia",surname:"Maldonado",slug:"cecilia-maldonado",fullName:"Cecilia Maldonado"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9086",title:"Drug Repurposing",subtitle:"Hypothesis, Molecular Aspects and Therapeutic Applications",isOpenForSubmission:!1,hash:"5b13e06123db7a16dcdae682eb47ac66",slug:"drug-repurposing-hypothesis-molecular-aspects-and-therapeutic-applications",bookSignature:"Farid A. 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Over the past few years, face recognition has become one of the most successful applications in computer vision and pattern recognition. It has received significant attention in several areas, such as law enforcement and surveillance (video surveillance and access control), smart cards (national ID and passports), information security (data management and file encryption), and entertainment (video game and virtual reality), among others [1].
Biometric-based technologies have been developed and implemented over the last century. These systems are the most promising for personal identification. Examples of modes of biometric systems include face recognition, fingerprints, iris scanning, and others [1].
Face recognition as a biometric technique appears to offer several advantages. The lack of interaction of the user is an important advantage regarding these types of systems appointed by [1]. In a fingerprint system, for example, the user needs to place his finger in a designated area, while in a face recognition system, the face images can be acquired passively.
Face recognition systems have, however, some level of complexity as there are some stages that are needed to execute in order to achieve a system with a good performance. Figure 1 presents these stages.
Configuration of a generic face recognition system.
Within each stage, there are specific operations that can be added in order to achieve better performance results. Right on the start, the image acquisition is a crucial step where there is room for improvement. Later, the face detection and recognition can be performed by specific algorithms which are presented and studied. Finally, two algorithms for face normalization (also known as preprocessing) algorithms, which are mentioned on state of the art articles, are also analyzed for this specific chapter.
State of the art face recognition is dominated by industry- and government-scale datasets. There is a large accuracy gap between today’s publicly available face recognition systems and the state of the art private face recognition systems [2]. However, this gap is closing up as better open-source algorithms and datasets with more and better images starts to appear.
Despite the success and high verification or recognition rates, there are still some challenges such as age, illumination, and pose variations. Most of these systems work well under constrained conditions (i.e., scenarios in which at least a few of the factors contributing to the variability between face images are controlled); however, the performance degrades rapidly when they are exposed to conditions where none of these factors are regulated [3].
Toward exploring this field and the increasing demand of these systems, an access control solution for unconstrained environments using face verification with open-source algorithms is presented in this chapter.
An introductory section is presented that provides a brief introduction to the face recognition system. In Section 2, the proposed solution is described. Later in this section, the major problems for a face recognition system for unconstrained environments are explained. These problems are some of the challenges that are tried to solve in this chapter. The several implemented algorithms are described in Section 3. In Section 4, experimental results showing the effectiveness of the proposed algorithms and the comparison between them are provided. Finally, a summary of the work done, comparison of the different experiments, concluding remarks, and the future work are featured in Section 5.
The proposed solution consists of the creation of a face verification (1:1 match comparison) system using open-source face recognition and detection algorithms in order to implement it in large-scale events with access control, such as sport infrastructures. To access this type of events, it is usually through the acquisition of a ticket/ID card. In order to improve the access control, the ticket access/acquisition is complemented with a face verification system.
The environment of these places is usually outdoors; therefore, the lighting conditions cannot be fully controlled [4]. Thus, the solution involves the use of cameras with adjustable parameters which do not have a proper calibration for these types of environments. An artificial light is also added which helps to compensate the lack or the excess of light in the scene.
As for software, two different programming languages, C++ and Python, are used. The C++ language is used for image acquisition and control of the camera parameters, including the calibration method since the cameras manufacturer only provides a library for the C programming language. Once the image is acquired, it is sent through a socket to a Python script that uses all the computer vision algorithms.
The solution is divided into two stages, registration and verification, that work independently of each other. Each process is divided into five scripts, where camera, facetracker, and NFC scripts are common to both stages. The database and interface scripts have some differences in both stages.
The different scripts are described as follows:
Figure 2 shows a block diagram of scripts communication.
Block diagram of communication between scripts.
In order to build a face verification system with these characteristics, an important factor is taken into account: the unconstrained environment where the system is going to be implemented. In a computer vision point of view, some problems related with these kinds of environments appear which are mentioned as follows:
The software developed obeys to some specific steps which are exposed in Figure 3.
Workflow diagram of the software developed.
In this section, a different type of calibration is proposed to acquire the best digital image for the face verification system.
When using the automatic calibration of the parameters provided by the camera, the whole image is considered when calibrating. Therefore, the region of interest (ROI) that will be acquired by the system can be affected by the light intensity that there is in the background and the image may not have the best quality.
In order to get the most suitable ROI (in this case, the face) for the system, it is attempted to create a calibration focused on this region.
The algorithm proposed is a mixture between the calibration of exposure time and gain.
Since the main goal is to implement the face verification system in an uncontrolled environment, an initial calibration is done using the auto-parameters calibration provided by the camera in order to adapt to the light and environment conditions and to detect the first face for the use of the calibration. At this point, a timer is set to wait a few seconds, so that the parameters of the camera have the time to be internally changed and established. Exposure time, gain, and white balance are the parameters changed automatically by the camera software.
When a face is found, the auto-parameter calibration is disabled and it continues to the next step of the calibration.
This calibration step is based in the mean sample value (MSV) from the image gray-level histogram of the region where the face is represented. Introduced by [5], the MSV is used to calibrate the exposure time and the gain of the camera.
In this stage, the MSV is calculated through the gray-level histogram of the face region with the equation described next:
where
It is worth noting that the pixels used for the MSV calculation are only the ones that are inside of the face-bounding box of the largest face found on the image.
A range of values is set for the MSV. If the calculated MSV is in range, between the values 2.1 and 2.5, the camera parameters (gain and exposure) have acquired values. Otherwise, the camera parameters are increased or decreased depending on whether the MSV is below the minimum value or above the maximum value, respectively.
This method has the main advantage that, if the same person appears on different parts of the day, the face images acquired will have very similar intensity values as the gain is calculated to have the same intensity values between a certain range.
This method addresses the situations when the face of a subject is partially exposed to sunlight which causes that part of the face too bright. To solve this, if a region where the intensity pixels have the maximum intensity found, the camera parameter values are decreased in order to reduce the brightness of that region of the face. In this case, when reducing the camera parameters, the side of the face that is not exposed to sunlight may become too dark. Therefore, the MSV value cannot be reduced far below the minimum value previously.
Figure 4 shows the comparison between parameter calibration provided by the camera and the proposed calibration, respectively.
Comparison between the automatic calibration (left image) and the proposed calibration (right image).
Several algorithms were studied and implemented into the system. Despite these algorithms being state of the art, where the use of neural networks is prevalent in an attempt of closing the gap between the performance of commercial and open-source of face recognition solutions, several other exist in the study [6].
In previous work [7], the Haar Cascades, Local Binary Patterns Cascade (LBP), and Histogram of Oriented Gradients (HoG) algorithms were studied for face detection. The FisherFaces and Local Binary Patterns Histograms (LBPH) algorithms were also studied for face recognition.
It is worth mentioning that the
Once the image is acquired, there is still some image processing that may improve the system accuracy toward detection and recognition.
Gamma is a very important characteristic in any digital system. In the world of cameras, it defines the relationship between a numerical value of a pixel and its actual luminance. The GC enhances the local dynamic range of the image in dark or shadowed regions while compressing it in bright regions and at highlights [17]. However, this operation is still affected by some level of directional lightning as pointed by [18].
Given a certain gamma (γ), the relation between the gray-level image with gamma correction (
As it is possible to analyze in Figure 5, the human eye does not relate the detected light with the actual luminance as a “linear” relationship.
Relation between the detected light and the actual luminance for both eyes (in blue) and camera (in purple) (
Figure 6 presents images with different gamma values, from the highest value to the lowest value (from the left to the right). As it is possible to analyze, the image with a higher gamma is more uniform regarding light.
Face images with different gamma values. From the highest value to the lowest value (from the left to the right) (
The ambition then is that using an appropriate gamma value, the images acquired will not be as susceptible to lighting variations.
CLAHE is an adaption of Adaptive Histogram Equalization (AHE) [19] that was first introduced for contrast enhancement for both natural and non-visual images [20]. This variation that introduced the limitation of contrast started began to be used in the face recognition field [21], which improved the contrast in face images.
Later, it began to see its utility in the facial recognition field, and a variation entitled contrast-limited adaptive histogram equalization (CLAHE) [19] was started to be used.
CLAHE is a preprocessing stage that focuses on improving the contrast in an image. This technique was applied as a preprocessing technique in [21] and it was applied on the face images in order to highlight the features that describe the face. The results exposed regarding recognition were improved with the addition of this stage.
In this approach, the face image is divided into small blocks, also called tiles, and in each of these blocks, the histogram equalization is applied. However, if any of the histograms calculated is above the predefined contrast limit, the pixels are clipped and distributed uniformly to other bins before applying histogram equalization. Figure 7 shows a face image before and after the application of the CLAHE, respectively.
Face image without (left image) and with (right image) the application of CLAHE.
In previous work, three degrees of freedom were used for face alignment [7]: yaw, pitch, and roll which are presented in Figure 8.
The three degrees of freedom of a human head that can be described by the egocentric rotation angles pitch, roll, and yaw [
In order to filter some of the input faces in face recognition algorithms, we use these three values to estimate the face position. For each value, a range is defined so that only the faces that are almost frontal to the camera are accepted as input of the face recognition algorithms.
In order to test the algorithms for the proposed solution, an access control system was simulated with face verification at the entrance of the research institute where dozens of people come and go during the day.
A prototype was developed with the available material. The prototype incorporates two cameras, an industrial camera and a webcam, on a tripod placed at a height of 1.5 m. Above the camera, an artificial illumination was placed. Since there were no available processing boards during the development of the system, a personal computer (ASUS VivoBook S14), Intel Core i7 8550U, was used instead. Finally, an NFC card reader (RFID-RC522) was connected to read the tag ID of each user both on the registration and verification stages. Also, it is worth mentioning that the PC display was used to show interactive messages explaining what the user should do. Figure 9 presents the setup of the system.
User interacting with the system setup for the experimental results.
The cameras used for tests are the IDS UI-1220LE-C (Industrial Camera) and the Logitech C310 (webcam). The purpose of the use of these cameras is to compare the performance between them in this specific system as the webcam does not allow to change its camera parameters such as exposure or gain.
On the other hand, the industrial camera, despite not being the most suitable for this scenario, provides a software development kit (SDK) that enables the complete control of its different parameters. In addition, as the industrial camera does not have a lens integrated, a 4.5-mm lens with manually adjustable aperture is used. Since the system is intended to be implemented at a fixed location, the most suitable lens aperture is defined.
In order to access the image data directly and to process the image captured by the webcam, the Video4Linux API using the OpenCV Video I/O module is used.
As for the industrial camera, an initial procedure is required to prepare the image capture.
In the first phase, the industrial camera is initialized to establish the connection. In order to obtain the image for the system, access to the image data stored in memory is required. To do that, it is necessary to obtain the sensor size as it determines the memory needed to allocate the image.
A 168 LED illumination with adjustable intensity is used in order to compensate the excess or lack of illumination. It also eliminates any occlusion that may be caused by external lightning. Another major advantage is its use on darker scenarios where the camera has a substantial exposure time. If the illumination is turned on, the scenario is clearer and the exposure time needed is lower, thus the blur caused by the person’s motion in the image is less than without illumination.
The tests were done in three distinct days where the first and the third day were sunny and the second one was cloudy. People who were entering the building were asked if they want to participate in this study. If the person agreed, he/she posed himself/herself in front of the camera and the registration was done (if it was the first time that the person presented in front of the camera). As for the next times the person appeared, the comparison between the face images made on registration and the ones acquired at the time was made. Figure 10 shows some of the face images acquired in different days.
Example of face images acquired in different days with different meteorological conditions.
About 50 people (a big majority of Caucasians from both sexes) participated, and all the participants entered the building at different times of the day which caused different types of directions of lighting in the face images acquired.
The comparisons between the face images registered in the database and the ones acquired next gave output values which were used to construct the receiver operating characteristic (ROC) curves. In total, about 2500 comparison values with both false and true positives were used to construct each curve presented next.
The first test analyzes the performance between the webcam with its automatic calibration and the industrial camera with the calibration proposed. Figure 11 presents the ROC curve as well as the area under curve (AUC) for this comparison. The HoG and the Openface algorithms were used with both cameras for detection and recognition, respectively.
ROC curve comparing the webcam and the industrial camera performance using the same algorithms.
Comparing the AUC resulting from the graphic presented in Figure 11, it can be concluded that the proposed method using the industrial camera is better than webcam.
In this section, the performance of the HoG and MTCNN face detection algorithms is presented. The time that it takes to detect faces in images with dimensions of 752×480 pixels was first measured. Posteriorly, the accuracy of each algorithm using a video recorded at the time of the tests was tested. Table 1 provides the results for both algorithms.
HoG | MTCNN | |
---|---|---|
Processing time (ms) | 60 | 121 |
Total detections | 592 | 740 |
False positives | 1 | 8 |
Processing times, total detections, and false positives for each face detection algorithm.
Analyzing this table, although the HoG algorithm has a lower processing time and less false positives, the MTCNN algorithm has the advantage of detecting faces in profile view and consequently detect more faces for the input of the face verification stage.
Results of the performance of the recognition algorithms tested with and without the preprocessing methods of gamma correction and CLAHE are presented here. As all algorithms are based on neural networks, it is important to point out that, despite using a specific preprocessing method, the network was not retrained. The results might improve if the preprocessing methods are applied to the images that are used to train the neural network.
Figures 12–14 present the algorithms performance using no preprocessing algorithms and comparing its results with the use of CLAHE and gamma correction.
ROC curve presenting the performance of OpenFace using CLAHE, gamma, and no preprocessing methods.
ROC curve presenting the performance of DML using CLAHE, gamma, and no preprocessing methods.
ROC curve presenting the performance of DeepFace using CLAHE, gamma, and no preprocessing methods.
Table 2 shows the processing time that takes each face image to forward pass the neural network of each algorithm.
OpenFace | DML | DeepFace | |
---|---|---|---|
Forward network runtime (ms) | 236 | 293 | 110 |
Processing times for forward pass in each network.
The results obtained using the proposed algorithms for face recognition show that the gamma correction revealed to have a negative impact in OpenFace and DML algorithms. As for DeepFace algorithm, the gamma correction does not have a significant impact on the output.
The preprocessing algorithm CLAHE has a positive impact in all face recognition algorithms used in this work.
Through the analysis in Figures 12–14 and Table 2, the DeepFace is the better algorithm for using in the face verification stage. The DeepFace is two times faster than the other proposed algorithms and the AUC is higher.
This chapter presented a face verification solution and studies where algorithms and cameras are appropriately used under uncontrolled environments. Regarding the camera and its calibration, the industrial camera had a better performance compared to the webcam as the calibration method presented focus on the best face image that can be acquired. As for software, both detection algorithms presented a good performance. Despite that, MTCNN seems to have the best performance as it detects faces where subject is in the profile view. In relation to the recognition and the preprocessing algorithms, CLAHE algorithm had a positive impact in all the recognition algorithms as for the gamma correction had a negative impact. It is believed that the results would improve if the preprocessing technique was applied in all the face images used for the training of the neural network. Unfortunately, the training of these types of neural networks takes over a day using powerful GPUs which are difficult to access. Despite that, the overall performance of the system was satisfactory and, from now on and according to the experiments, the best solution for this system is the use of an industrial camera, MTCNN for face detection, CLAHE for preprocessing, and DeepFace for the face verification stage.
The future work goes through the implementation of the solution in larger scales where more people would use it. Until then, the training of new neural networks using the preprocessing techniques is presented, and the study of new alternatives for cameras is on the agenda.
This work is partially funded by National Funds through the FCT—Foundation for Science and Technology in the context of the project UID/CEC/00127/2013.
In 1916, Einstein proposed the theory of stimulated radiation, which laid a theoretical foundation for the emerging of lasers. Till 1960, the world’s first laser was invented by Mehman. Since then, flash-pumping has been widely employed for laser technology to generate beams with good monochromaticity, excellent coherence and promising directivity. Moreover, with the advent of laser diodes (LD), diode-pumped solid-state lasers have achieved rapid development for many advantages such as high efficiency, small size, and high beam quality compared with flash-pumped lasers. However, free-running lasers have relaxation oscillations, which deliver series of disordered small pulse spikes that do not possess high or stable peak powers. With the directional stored energy further modulated temporally, the laser operation regime would gradually evolve from continuous wave (CW) to Q-switching. It is well known that Q-switching is always an efficient method for generating pulsed lasers for any wavelength, since it provides an efficient way to obtain short laser pulses with high peak power, which is much beneficial for scientific or practical applications in terms of light-matter interactions. By using the Q-switching technology, the pulse peak power can reach KW or even MW level, and the pulse energy reaches mJ or even J level, which are very suitable for medical and industrial fields.
In recent years, 2 μm lasers located in the eye-safe spectral range have gained much attention because of their wide applications in the fields of environmental monitoring [1], laser medicine [2], laser radar [3, 4], micro-machining, material processing [5], and so on. In addition, the 2 μm lasers can also be used as pump sources for producing the mid- and far-infrared lasers. For example, they can be used as high-efficiency pumping sources for optical parametric oscillators (OPOs) and optical parametric amplifiers (OPAs) to achieve broadband tunable lasers in the mid-infrared spectral range of 3–5 and 8–12 μm [6, 7, 8]. However, it should be noticed that in practical applications, such as laser surgery, industrial processing, and nonlinear optics, laser pulses with high peak powers are required. Therefore, nanosecond 2 μm laser source with high peak power, large pulse energy and excellent stability is of great significance and has become an important topic of current research on 2 μm lasers.
As mentioned above, Q-switching technology is not an exceptional choice for obtaining nanosecond 2 μm solid-state lasers with high peak power. According to the different operation regimes, Q-switching technology can be divided into active and passive Q-switching (PQS). The basic principle of active Q-switching is regularly modulating the intracavity losses by a voltage controlled modulator, including electro-optic (EO) and acousto-optic (AO) modulators. Although actively Q-switched lasers are frequency adjustable, stable and reliable, they have the disadvantages of large size and expensive cost. Passive Q-switching technology is a good choice to overcome them. In passively Q-switched lasers, the saturable absorber (SA) is the key element and thus the output laser characteristics strongly depend on the nature of the SA materials. Up to now, semiconductor saturable absorber mirrors (SESAMs), chromium doped II-VI semiconductor materials (Cr2+: ZnSe/S), and low-dimensional nanomaterials have been widely studied and regarded as reliable SAs for 2 μm lasers. However, the utilization of SESAMs is restricted by the complicated and expensive fabrication process as well as narrow absorption bandwidth. At present, the low dimensional nanomaterials with advantages of broadband absorption and low cost have been attractive candidates as SAs for PQS.
Up to now, flash-pumped solid-state lasers are still widely used in industry and medical science, because of the advantage of high energy output. In general, the flash-pumping way can support larger mode area than that of diode-pumping regime, which is critical for high energy laser output. To increase the absorption efficiency, Cr3+ ions are usually co-doped as sensitizer/activator for Tm or Tm-Ho host materials when flash-pumped. Under this situation, the energy level diagram for Cr,Tm,Ho: YAG crystal is illustrated in Figure 1. The flash pump light is absorbed by the broadband Cr3+ ions. After a nonradiative decay to and within the 4T2 and 2E states, the excitation is transferred from the Cr3+ ion to the 3F3 and 3H4 states of the Tm3+ ion, via dipole–dipole interactions. Nonradiative decay of the 3F3 places virtually all the excited ions in the 3H4 state. Each excited Tm3+ ion then interacts with a ground state of Tm3+ ion in a cross-relaxation process which gives rise to two Tm3+ ions in the 3F4 state. Finally, these Tm3+ ions transfer their energy to two Ho3+ ions to populate the 5I7 upper laser level, and lasing occurs between the 5I7 and 5I8 transition at 2.097 μm [9].
Energy level diagram for Cr,Tm,Ho:YAG, CR: cross relaxation.
In 1962, Johnson et al. in Bell Labs, USA achieved the firstly 2.06 μm laser emission, but this laser was typically cooled by liquid-N2 at 77 K and the output power was very low. Lately, it was found that some rare earth ions can sensitize Ho3+, thus a Er,Tm,Ho:YAG laser was realized with a slope efficiency of 5% with aid of liquid-N2 cooling. In 1985, Antipenko et al. increased the flash-pumping efficiency and achieved the first 2 μm laser output at room temperature by replacing Er3+ with Cr3+. But CW operation cannot satisfy the requirements of high peak power and narrow pulse width in many applications. Then Q-switching technology was utilized including passive and active Q-switching methods.
In 1996, Kuo et al. used Ho:YVO4 and Ho:CaF2 crystals as SAs for Tm,Cr:YAG lasers, and the corresponding pulse energies and pulse widths were 3.5 mJ, 45 ns and 5.1 mJ, 60 ns at 2.017 μm, respectively [10, 11]. In 2001, flash-lamp-pumped Ho:YAG (2090 nm) and Tm:YAG (2017 nm) lasers were passively Q-switched based on a Cr2+:ZnSe SA for the first time, from which a Q-switched Ho laser with 1.3 mJ pulse energy and ~90 ns pulse duration and a Q-switched Tm laser with ~3.2 mJ pulse energy and 90 ns pulse duration were demonstrated [12]. In 2005, Gaponenko et al. realized passively Q-switched Cr,Tm,Ho:Y3Sc2Al3O12 and Cr,Tm,Ho:YAG lasers using PbS SAs, where the pulse energies and pulse widths were 2.4 mJ, 50 ns and 4.5 mJ, 70 ns at about 2.09 μm, respectively [13]. However, because the pulse energies were too low to satisfy the demands of practical application, active Q-switching technology was applied in flash-lamp-pumped 2 μm lasers.
In 1991, Bowman et al. designed an AO Q-switched Cr,Tm,Ho:YAG laser using a quartz crystal with Brewster angle placed in the cavity. At temperature of 20°C, the pulse energy of 110 mJ with the pulse width of 40 ns was obtained at the repetition rate of 1 Hz [14]. Two years late, they achieved AO Q-switched Cr,Tm,Ho:YAG laser with pulse energy of 24 mJ and duration of 90 ns at a repetition rate of 29 Hz [15]. In 2000, using flash-lamp-pumping, an AO Q-switched Cr,Tm:YAG laser was realized with a maximum pulse energy exceeding 0.8 J and a pulse width of 135 ns [16]. In 2005, Zheng et al. reported a AO Q-switched Cr,Tm,Ho:YAG laser delivering a pulse energy of 120 mJ and a pulse width of 90 ns at the repetition rate of 10 Hz [17].
Besides AO modulator, EO modulator is also a common method to modulate flash-lamp-pumped 2 μm lasers, which could further shorten the pulse duration. In 1981, Gettermy et al. reported a LiNbO3 (LN) crystal based EO Q-switched Ho:YAG laser, which had to be cooled down to 77 K to obtain high energy and short pulses. A pulse energy of 80 mJ with a pulse width of 30 ns at the repetition rate of 5 Hz was obtained [18]. In 1990, Henderson et al. reported a EO Q-switched Cr,Tm,Ho:YAG laser using a LN crystal as modulator. At the repetition rate of 3 Hz, the pulse energy of 50 mJ with a corresponding pulse width of 150 ns was obtained [19]. In 1993, Kim et al. also achieved a pulse energy of 50 mJ from a LN based EO Q-switched Cr,Tm,Ho:YAG laser at 170 K [20]. In 2008, Nieuwenhuis et al. utilized RbTiOPO4 (RTP) crystal as EO modulator in a lamp-pumped Cr,Tm,Ho:YAG laser, and obtained a pulse width of 100 ns with a pulse energy of 42 mJ [21]. In 2012, a flash-lamp-pumped 2.09 μm Cr,Tm,Ho:YAG laser utilizing a La3Ga5SiO14 (LGS) crystal as the EO modulator is proposed and demonstrated for the first time, which results are shown in Figure 2. Operated at a repetition rate of 3 Hz, a pulse energy as high as 520 mJ with a 35 ns pulse width was achieved by optimizing the delay time of EO modulator and compensating for the thermal depolarization with a quarter-wave plate. The corresponding pulse peak power was 14.86 MW, and the energy extraction efficiency was 66.3% [22].
Schematic setup of flash-lamp-pumped EO Q-switched Cr,Tm, Ho:YAG laser. [Reprinted/Adapted] With permission from Ref. [
In conclusion, as shown in Table 1, flash-pumped 2 μm solid-state lasers have been well developed for generating high pulse energy, especially in combination with active Q-switching methods. To now, the highest single pulse energy obtained at 2 μm was 800 mJ, with corresponding pulse duration of 135 ns by using an AO modulator. As for flash-pumped EO Q-switched 2 μm solid-state lasers, the highest single pulse energy of 520 mJ was achieved with a corresponding pulse width of 35 ns, which delivered the highest pulse peak power from the flash-pumped 2 μm solid-state laser, to the best our knowledge. In the future, flash-pumped 2 μm solid-state lasers still have great potential for various applications demanding high energy.
Modulator | Gain media | Durations (ns) | Energy (mJ) | Time | Ref. |
---|---|---|---|---|---|
Ho:YVO4 | Tm,Cr:YAG | 45 | 3.5 | 1966 | [10] |
Ho:CaF2 | Tm,Cr:YAG | 30 | 5.1 | 1966 | [11] |
Cr:ZnSe | Ho:YAG | 90 | 1.3 | 2001 | [12] |
Cr:ZnSe | Tm:YAG | 90 | 3.2 | 2001 | [12] |
PbS | Cr,Tm,Ho:YSAG | 50 | 2.4 | 2005 | [13] |
PbS | Cr,Tm,Ho:YAG | 70 | 4.5 | 2005 | [13] |
AO | Cr,Tm,Ho:YAG | 40 | 110 | 1991 | [14] |
AO | Cr,Tm,Ho:YAG | 90 | 24 | 1993 | [15] |
AO | Cr,Tm:YAG | 135 | 800 | 2000 | [16] |
AO | Cr,Tm,Ho:YAG | 90 | 120 | 2005 | [17] |
LN | Ho:YAG | 30 | 80 | 1981 | [18] |
LN | Cr,Tm,Ho:YAG | 150 | 50 | 1990 | [19] |
LN | Cr,Tm,Ho:YAG | — | 50 | 1993 | [20] |
RTP | Cr,Tm,Ho:YAG | 100 | 42 | 2008 | [21] |
LGS | Cr,Tm,Ho:YAG | 35 | 520 | 2012 | [22] |
Overview of flash-pumped Q-switched 2 micron solid-state lasers.
The AO modulator has the advantages of high damage threshold, easy operation, and low insertion loss. It is capable of generating peak power as high as several hundred kilowatts, high repetition frequency, and short pulse width with several tens of nanoseconds. Thus, AO Q-switching has attracted a lot in generating 2 μm laser pulses based on Tm3+ or Ho3+ ions doped crystals.
The actively Q-switched Tm3+ doped laser can be traced back to 1991, when Suni et al. realized a LD-pumped AO Q-switched Tm:YAG laser with the pulse width of 330 ns and the single pulse energy of 1 mJ at the repetition frequency of 100 Hz [23]. In 2004, Sullivan et al. realized a high-power Q-switched Tm:YAP laser with a maximum output power of 50 W at 1940 nm. At the repetition rate of 5 kHz, the maximum pulse energy was 7 mJ with a corresponding pulse width of 75 ns [24]. But it was low temperature of −10°C. In 2008, Cai et al. realized a diode-pumped AO Q-switched Tm:YAP laser with a maximum single pulse energy of 1.57 mJ and the minimum pulse width of 80 ns at a repetition rate of 1 kHz under room temperature [25]. In 2010, Li et al. showed another double-diode end-pumped AO Q-switched c-cut Tm:YAP laser, which delivered a maximum average output power of 12.5 W at a repetition rate of 10 kHz with a pulse width of 126 ns [26]. In 2015, Yumoto et al. realized AO Q-switched Tm:YAG laser at a center wavelength of 2.013 μm. The maximum pulse energy of 128 mJ was obtained at a repetition rate of 10 Hz, corresponding to a minimum pulse width of 160 ns [27], which was the largest pulse energy for AO Q-switched 2 μm laser. In 2015, Luan et al. realized a 790 nm diode-pumped doubly Q-switched Tm:LuAG laser simultaneously with AO modulator and multilayered graphene as Q-switches, from which a minimum pulse width of 170 ns with a corresponding pulse energy of 0.53 mJ was obtained at a repetition rate of 1 kHz [28]. The results well indicated that doubly Q-switching technique could efficiently shorten the pulse duration.
Efforts are not stopped being paid on exploring diode-pumped solid-state AO Q-switched lasers based on novel kinds of Tm3+ and Ho3+ doped crystals. In 2017, Liu et al. demonstrated an AO Q-switched Tm,Y:CaF2 laser in a V-type cavity as shown in Figure 3, which could run at high repetition rates from 1 to 10 kHz [29]. Under the modulation frequency of 1 kHz, pulses with the shortest duration of 280 ns and the maximum pulse energy of 0.335 mJ were delivered, corresponding to a maximum peak power of 1.19 kW. In 2019, Zagumennyi et al. reported a novel AO Q-switched Tm:Yb3Al5O12 (Tm:YbAG) laser pumped by the 1.678 μm laser. The pulse energy was 100 μJ with a pulse duration of 45 ns at the repetition rate of 6.7 kHz [30].
Experimental setup of the actively Q-switched Tm,Y:CaF2 laser. [Reprinted/Adapted] With permission from Ref. [
In addition to the Tm lasers emitting around 1.9–2.0 μm, Ho3+ ions can emit laser radiations at around 2.0–2.1 μm due to the transition 5I7–5I8, which can keep away from the water vapor absorption and is helpful for the applications requiring free space transmission. Moreover, Ho3+ ion with long upper laser level lifetime are attractive for Q-switched operation. Since Tm3+ ions have absorption bands around 800 nm where commercial GaAs/AlGaAs diodes are available, a Tm sensitized Ho laser is an ideal way to achieve a ∼ 2.1 μm laser. In 2005, Yao et al. realized the AO Q-switched Tm,Ho:GdVO4 laser under liquid nitrogen refrigeration. And the maximum pulse energy of 1.1 mJ and minimum pulse duration of 23 ns were obtained at a repetition rate of 3 kHz [31]. In 2010, Yao et al. investigated the characteristics of AO Q-switched Tm,Ho:YVO4 laser under low temperature conditions. A maximum output power of 19.4 W was achieved with a pulse width of 24.2 ns at a repetition rate of 15 kHz [32]. In 2017, Li et al. achieved a stable AO Q-switched Tm,Ho:YAP laser with a pulse width of 66.85 ns and a single pulse energy of 0.97 mJ at the repetition rate of 7.5 kHz and temperature of 77 K cooled by the liquid nitrogen in Dewar bottle [33]. However, the above Tm,Ho co-doped laser were operated under low temperature conditions, which limited their applications.
As for Ho laser emitting around 2 μm, another way is resonantly pumping Ho laser by an extracavity Tm laser, which has high conversion efficiency and low thermal load. Thus, Ho-doped laser is also a vital approach to obtain high output power and pulse energy laser at wavelength over 2 μm. In 2012, Lamrini et al. realized an actively Q-switched Ho:YAG laser based on an AO modulator at 2.09 μm by using a 1.9 μm LD as the pump source, which schematic setup is shown in Figure 4. At the repetition rate of 100 Hz, the obtained maximum pulse energy and minimum pulse width were 30 mJ and 100 ns, respectively [34]. In 2014, an AO Q-switched Ho:GdVO4 was realized end-pumped by a 1942 nm Tm-fiber laser, delivering a pulse width of 4.7 ns and an output pulse energy of 0.9 mJ at the repetition frequency of 5 kHz, corresponding to a peak power of 187.2 kW [35]. In 2014, Wang et al. used a 1.908 μm Tm:YLF solid-state laser as the pump source to realize an actively Q-switched Ho:YAG ceramic laser at 2.097 μm based on an AO Q-switch. The maximum pulse energy and minimum pulse width were 10.2 mJ and 83 ns at the repetition rate of 100 Hz [36]. In 2016, Ji et al. used a 1.94 μm LD as the pump source to realize an actively Q-switched Ho:YLF solid-state laser based on an AO Q-switch at 2.06 μm. The maximum pulse energy of 1.1 mJ was achieved with a corresponding minimum pulse duration was 43 ns at the repetition rate of 100 Hz [37]. Up to present, many Ho lasers based on various hosts have been demonstrated. However, there is rare report on the Ho laser with more than 100 W output power. In 2018, Duan et al. reported a Ho:YAG laser with the output power of up to 108 W in CW mode and 106 W in Q-switching mode, respectively [38]. As far as we know, this is the highest output power of CW and Q-switched Ho lasers ever reported. A pulse energy of 5.3 mJ and a pulse duration of 21 ns were obtained, corresponding to a pulse peak power of approximately 252 kW.
Resonator of the AO Q-switched Ho(0.5%):YAG laser formed by mirror M1 and mirror M3 (output coupler). [Reprinted/Adapted] With permission from Ref. [
In conclusion, AO Q-switching is an effective method to obtain pulsed 2 μm lasers. Table 2 shows the summaries of diode-pumped AO Q-switched 2 micron solid-state lasers reported in recent years. From it, we can see that the maximum single pulse energy ever achieved based on AO Q-switching method is 128 mJ. However, for high-energy or high-power lasers, the turn-off capacity of AO switching is poor. In practical, most applications demand pulsed 2 μm lasers with large power, high pulse energy and repetition rate, which sets an important challenge for AO modulators to overcome.
Gain media | Durations (ns) | Frequency (kHz) | Energy (mJ) | Wavelength (μm) | Time | Ref. |
---|---|---|---|---|---|---|
Tm:YAG | 330 | 0.1 | 1 | 2.015 | 1991 | [23] |
Tm:YAP | 75 | 5 | 7 | 1.94 | 2004 | [24] |
Tm:YAP | 80 | 1 | 1.57 | 1.99 | 2008 | [25] |
Tm:YAP | 126 | 6 | 1.6 | 1.99 | 2010 | [26] |
Tm:YAG | 160 | 0.01 | 128 | 2.015 | 2015 | [27] |
Tm:LuAG | 170 | 1 | 0.53 | 2.023 | 2015 | [28] |
Tm,Y:CaF2 | 280 | 1 | 0.335 | 1.912 | 2017 | [29] |
Tm:YbAG | 45 | 6.7 | 0.1 | 2.02 | 2019 | [30] |
Tm,Ho:GdVO4 | 23 | 3 | 1.1 | 2.05 | 2005 | [31] |
Tm,Ho:YVO4 | 24.2 | 15 | 1.3 | 2.055 | 2010 | [32] |
Tm,Ho:YAP | 66.85 | 7.5 | 0.97 | 2.119 | 2017 | [33] |
Ho:YAG | 100 | 0.1 | 30 | 2.09 | 2012 | [34] |
Ho:GdVO4 | 4.7 | 5 | 0.9 | 2.05 | 2014 | [35] |
Ho:YAG | 83 | 0.1 | 10.2 | 2.097 | 2014 | [36] |
Ho:YLF | 43 | 0.1 | 1.1 | 2.06 | 2016 | [37] |
Ho:YAG | 21 | 20 | 5.3 | 2.09 | 2018 | [38] |
Overview of AO Q-switched 2 μm solid-state lasers.
EO Q-switching is an important way of obtaining high peak power and narrow pulse width which has the advantages of fast switching speed, high extinction ratio and small volume. The peak power of this kind of laser can easily reach hundreds of megawatts. The most important component in EO Q-switch is EO crystal, many EO crystals including LiNbO3 (LN), RbTiOPO4 (RTP) and La3Ga5SiO14 (LGS) have been successfully applied in the 2 μm EO Q-switched lasers.
From 1970s on, LN crystals have been used as the EO crystal to generate laser pulses, which is exceptional for its no deliquescence, low half-wave voltage, and lateral modulation, etc. In 2015, based on LN crystal Liu et al. reported a diode-pumped EO Q-switched Tm:LuAG laser generating a pulse energy of 2.51 mJ with a pulse width of 88 ns at a repetition rate of 50 Hz [39]. In 2016, with Tm,Ho:YAP crystal as gain material and EO Q-switch based on LN crystal, a maximum pulse energy of 1.65 mJ and a shortest pulse duration of 107.4 ns were obtained at a repetition rate of 200 Hz [40]. In 2018, to lower down the thermal effect of gain medium, Guo et al. incorporated diode-wing-pumping technique into a LN EO Q-switched Tm:LuAG laser. A maximum pulse energy of 10.8 mJ and a minimum pulse width of 52 ns at a repetition rate of 100 Hz was delivered, as shown in Figure 5 [41]. However, further increase of pule energy is limited by the relatively low damage threshold of LN crystal.
Schematic of EO Q-switched Tm:LuAG laser. [Reprinted/Adapted] With permission from Ref. [
RTP crystal belongs to orthorhombic crystal system and has large EO coefficient, high damage threshold and broad transmission range. In 2013, using a 1.94 μm Tm3+ fiber laser as the pump source, Fonnum et al. realized a RTP EO Q-switched Ho:YLF laser utilizing the setup shown in Figure 6. A maximum pulse energy of 550 mJ and a minimum pulse width of 14 ns at a repetition rate of 1 Hz were obtained [42]. In 2016, a diode-pumped RTP EO Q-switched Tm:YAG slab laser delivered a maximum pulsed energy of 7.5 mJ with a pulse width of 58 ns [43]. However, since RTP crystal is biaxial, two crystals with the same size and direction are required to combine with each other to offset natural birefringence, which greatly increases the difficulty of crystal processing. Moreover, under high-power operation regime, thermal induced birefringence can deteriorate switching performance of the RTP EO Q-switch, which subsequently limits the obtained pulse energy and output power.
Schematic setup of the Tm:fiber pumped RTP EO Q-Switched Ho:YLF laser. [Reprinted/Adapted] With permission from Ref. [
In 2003, LGS crystal was firstly grown and studied in Institute of Crystal Materials of Shandong University. LGS crystal is uniaxial and thus free of birefringence induced problems. Compared with LN, the LGS crystal has a 9.5-times-higher anti-photo-damage threshold. Additionally, LGS crystal has a broadband transparency from 190 to 2400 nm, good physical and chemical stability, small thermal expansion coefficient and considerable electro-optic coefficient (γ11 = 2.3 × 10−12 m/V). Kong et al. firstly employed LGS crystal as EO Q-switch in a Nd:YAG laser and achieved pulsed operation at 1 μm [44]. Very recently, Ma et al. realized a LGS EO Q-switched Tm:YAP laser with a maximum repetition rate of 200 kHz, a maximum average output power of 2.79 W and a minimum pulse width of 5.5 ns [45].
In conclusion, EO Q-switch plays a crucial role in generating high-energy laser pulses and suitable choice of EO crystal can determine the performance of EO Q-switch. At present, LN, RTP, and LGS are the most successful EO crystals. For LD pumped 2 μm solid lasers, 550-mJ single pulse energy set a record, to the best of our knowledge. However, exploring excellent EO crystals with high damage threshold, low driven voltage, high repetition rate and the small volume are still on the way (Table 3).
EO crystal | Gain media | Duration (ns) | Frequency (kHz) | Energy (mJ) | Wavelength (μm) | Time | Ref. |
---|---|---|---|---|---|---|---|
LN | Tm:LuAG | 88 | 0.05 | 2.51 | 2.023 | 2015 | [39] |
LN | Tm,Ho:YAP | 107 | 0.2 | 1.65 | 2.13 | 2016 | [40] |
LN | Tm:LuAG | 52 | 0.1 | 10.8 | 2.023 | 2018 | [41] |
RTP | Tm:LuAG | 3 | 100 | 0.0122 | 2.013 | 2016 | [46] |
RTP | Ho:YLF | 14 | 0.001 | 550 | 2.051 | 2013 | [42] |
RTP | Tm:YAG | 58 | 1 | 7.5 | 2.015 | 2016 | [43] |
LGS | Tm:YAP | 5.5 | 200 | 0.0139 | 1.99 | 2019 | [45] |
Overview of EO Q-switched 2 μm solid-state lasers.
In recent years, two-dimensional (2D) material based SAs have been widely used in generating laser pulses. The family of 2D materials includes graphene, black phosphorus (BP), transition metal dichalcogenides (TMDs) and topological insulators (TIs), and so on [47]. There are several methods available for fabricating 2D materials, including micromechanical exfoliation, chemical synthesis, pulsed laser deposition (PLD) and liquid phase exfoliation (LPE) [48, 49]. To fabricate 2D material, LPE is widely used because of its simplicity and effectiveness. Layered materials can be directly exfoliated from their bulk counterparts by this method.
Graphene, a single atomic layer of carbon atom, has attracted particular interest due to its broadband absorption, controllable modulation depth and low non-saturable loss. However, low absorption in graphene limits its applications. In 2012, graphene was firstly used as SAs at 2 μm region [50]. The obtained maximum average output power, pulse repetition rate, and single pulse energy were 38 mW, 27.9 kHz, and 1.74 μJ, respectively. Since then, graphene has been widely applied in many kinds of Tm−doped crystals based 2 μm lasers, such as Tm:LSO, Tm:YAP, Tm:LuAG, Tm,Y:CaF2, and et al. [28, 51, 52, 53].
Another kind of 2D material, TMDs, has also been widely studied in recent years. Properties of few-layered TMDs depend on the number of layers. For instance, bulk MoS2 has an indirect 1.29 eV (961 mm) bandgap, while monolayer MoS2 has a direct 1.8 eV (689 nm) bandgap. However, many reports show the saturable absorption property of few-layered TMDs at near-infrared wavelength region, which corresponds to photon energies smaller than material bandgap for most of TMDs. In a perfect crystalline semiconductor, incident photons with energy lower than the bandgap cannot be absorbed. However, crystallographic defects, including edges and vacancies, enable such absorption [54]. In 2014, Wang et al. concluded that by introducing defects with a suitable quantity range, the bandgap of MoS2 could be reduced from 1.08 (R = 1:2) to 0.08 eV (R = 1:2.09), corresponding to an absorption wavelength from 1.1 to 15.4 μm, which showed that MoS2 with S defects could be used as a kind of broad SA. Passively Q-switched lasers based on MoS2 SA in the range of 1–2 μm have been demonstrated [48].
BP, a layered allotrope of phosphorus, also exhibits a layer-dependent direct bandgap, which is tunable from 0.3 eV (bulk) to 2.0 eV (monolayer), corresponding to an absorption band from 620 nm to 4.13 μm. However, different from MoS2, which owns indirect band-gap at multilayer format, BP always has the direct transition for all thickness. But it has an intrinsic disadvantage of easy oxidation. In 2015, Lu et al. reported the broadband and enhanced SA property of multi-layered BP (with a thickness of ~10 nm) by wide-band Z-scan method [49]. At the same year, Jiang et al. demonstrated passively Q-switched operation of Tm−doped fiber laser based on BP SAs [55]. In 2016, Xie et al. achieved a BP Q-switched Tm:YAG ceramic laser generating pulses with a maximum average output power of 38.5 mW, pulse energy of 3.32 μJ, and pulse width of 3.12 μs [56]. Zhang et al. demonstrated a compact Q-switched Tm:YAP laser based on multi-layered BP nanoplatelets, which delivered an average output power of 3.1 W and a pulse duration of 181 ns at a repetition rate of 81 kHz [57].
Another group of 2D materials, TIs such as Bi2Te3 and Sb2Te3, have also been proposed and investigated in recent years. In general, bulk TIs materials have a small bandgap but a gapless metallic surface state is generated in layered 2D TIs, which is caused by strong spin-orbit coupling and time-reversal symmetry [58]. With such typical band structure, 2D TIs materials show broadband absorption like CNTs and graphene and have become one of promising optical modulator candidates in generating 2 μm laser pulses.
In conclusion, 2D material based SAs have attracted much attention in generating laser pulses due to its advantage of easy fabrication, compact setup, and broadband optical absorption. Related reports on passively Q-switched 2 μm solid-state lasers based on 2D material SAs are summarized in Table 4. However, the obtained output powers are in the order of several hundred mW and the pulse widths are in the order of several hundred ns, especially the pulse energies are only with tens of microjoules, which limits the pulse peak power and their applications furthermore. In the future, the damage thresholds of the 2D material based SAs should be greatly increased, which would benefit the increase of the output power and pulse energy as well as the long-term stabilities of the Q-switched lasers.
SAs | Gain media | Output power (mw) | Duration (ns) | Frequency (kHz) | Energy (μJ) | Time | Ref. |
---|---|---|---|---|---|---|---|
Graphene | Tm:YAG | 38 | 2250 | 27.9 | 3.8 | 2012 | [50] |
Tm:LSO | 106 | 7800 | 7.6 | 14 | 2013 | [51] | |
Tm:YAP | 362 | 735 | 42.4 | 8.5 | 2014 | [52] | |
Ho:LuAG | 370 | 752.2 | 48.8 | 7.5 | 2016 | [28] | |
Tm,Y:CaF2 | 400 | 1316 | 20.22 | 20.4 | 2018 | [53] | |
MoS2 | Tm,Ho:YGG | 205.62 | 410 | 149 | 1.38 | 2014 | [48] |
Tm:CLNGG | 79.2 | 4840 | 110 | 0.72 | 2015 | [59] | |
Tm:GaVO4 | 100 | 800 | 48.09 | 2.08 | 2015 | [60] | |
Tm,Ho:YAP | 275 | 435 | 55 | 5 | 2017 | [61] | |
Tm:CYA | 490 | 480 | 102.6 | 4.87 | 2017 | [62] | |
BP | Tm:YAP | 3199.5 | 181 | 81 | 39.5 | 2016 | [57] |
Tm:YAP | 150.92 | 1780 | 19.25 | 7.84 | 2016 | [63] | |
Tm:CaYA | 12 | 3100 | 17.7 | 0.68 | 2016 | [64] | |
Tm:YAG | 38.512 | 3120 | 11.6 | 3.32 | 2016 | [56] | |
Bi2Te3 | Tm:LuAG | 2030 | 620 | 118 | 18.4 | 2017 | [65] |
Sb2Te3 | Tm:GdVO4 | 700 | 223 | 200 | 3.5 | 2018 | [66] |
Overview of 2D nanomaterials modulated 2 μm solid-state lasers.
Since Podlipensky et al. demonstrated that Cr2+:ZnSe crystals can be used as SAs for 1.54 μm Er:glass lasers [67], Cr2+ doped II-VI compounds like Cr2+:ZnS and Cr2+:ZnS have been widely used in the spectral range of 1.5–2.1 μm. Figure 7 shows that Cr:ZnS and Cr:ZnSe have broadband absorption spectra form 1.5 to 2.2 μm [68].
Absorption (black) and emission (red) cross-sections of ZnS and ZnSe doped with Cr2+ ions. [Reprinted/Adapted] With permission from Ref. [
Up to now, Cr:ZnSe/ZnS have been applied in many 2 μm pulsed lasers, as shown in Table 5. In 2015, Sebbag realized a Cr:ZnSe Q-switched Tm:YAP solid-state laser at 1935 nm, which delivered a pulse energy of 1.55 mJ and a pulse duration of 42.2 ns, corresponding to a peak power of 36.7 kW [71]. In 2017, Lan reported a Cr:ZnSe Q-switched Tm:CYA laser with a maximum repetition rate of 21.9 kHz, a minimum pulse width of 42.6 ns and a maximum pulse energy of 60.2 μJ [73]. In 2017, a Cr2+:ZnSe passively Q-switched Nm–cut Tm:KLu(WO4)2 mini-slab laser was reported, where the obtained shortest pulse duration was 35 ns and maximum pulse energy was 0.3 mJ [90]. Due to the low absorption cross-section of Cr:ZnSe crystal around 2 μm, it was mainly used in Tm-doped crystal based lasers. In 2013, A Cr2+:ZnS passively Q-switched Ho:YAG laser pumped by a Tm:YLF laser was demonstrated with a maximum pulse energy of 2.47 mJ, a minimum pulse duration of 36.6 ns at a repetition rate of 10.4 kHz [81]. In 2015, a diode-pumped Cr:ZnS passively Q-switched Tm:KLu(WO4)2 microchip laser generated sub-nanosecond (780 ps) pulses with a pulse repetition frequency of 5.6 kHz, which was the shortest pulse duration among the passively Q-switched 2 μm lasers ever achieved [85]. Besides, in 2017, another novel Cr2+ ions doped Cr:CdSe crystal was firstly demonstrated in a Ho: YAG laser at 2.09 μm. A maximum output pulse energy of 1.766 mJ at a repetition frequency of 685 Hz was obtained with a pulse duration of 15.4 ns, which indicated that a Cr:CdSe crystal could be a promising SA in passively Q-switched 2 μm lasers [89].
SAs | Gain media | Output power (W) | Duration (ns) | Frequency (kHz) | Energy (μJ) | Time | Ref. |
---|---|---|---|---|---|---|---|
Cr:ZnSe | Tm:YAG | 1.6 | 300 | 4 | 400 | 2003 | [69] |
Tm,Ho:YLF | 0.1 | 40 | 4 | 25.6 | 2014 | [70] | |
Tm:YAP | 0.87 | 42.2 | 0.561 | 1550 | 2015 | [71] | |
Tm:YLF | 0.027 | 1200 | 2.1 | 13 | 2014 | [72] | |
Tm:CYA | 1.32 | 42.6 | 21.9 | 60.2 | 2017 | [73] | |
Tm:CYA | 0.25 | 107 | 5.85 | 48.2 | 2017 | [74] | |
Tm:CGA | 0.64 | 44 | 13.9 | 46 | 2017 | [75] | |
Tm:KLuW | 3.2 | 35 | 6.3 | 300 | 2017 | [75] | |
Ho:SSO | 2.4 | 73.5 | 2.65 | 900 | 2017 | [76] | |
Cr:ZnS | Tm:KLW | 0.39 | 25 | 2.7 | 145 | 2012 | [77] |
Tm:YLF | 0.098 | 14 | 0.12 | 850 | 2012 | [78] | |
Tm,Ho:YLF | 0.016 | 1250 | 1.3~2.6 | 4 | 2012 | [79] | |
Tm:LLF | 0.2 | 7.6 | 0.161 | 1260 | 2012 | [80] | |
Ho:YAG | 16.6 | 36.6 | 10.4 | 2470 | 2013 | [81] | |
Tm,Ho:LuLiF4 | 0.074 | 1200 | 5.8 | 13 | 2013 | [82] | |
Tm,Ho:GdVO4 | 3.2 | 354 | 52 | 70.5 | 2013 | [83] | |
Tm,Ho:YVO4 | 0.3 | 500 | 65 | 3.5 | 2014 | [84] | |
Tm:KLW | 0.146 | 0.78 | 5.6 | 25.6 | 2015 | [85] | |
Ho:YAG | 14.8 | 29 | 24.4 | 600 | 2015 | [86] | |
Ho:LuAG | 1.14 | 36 | 0.79 | 1540 | 2015 | [87] | |
Ho:YAP | 6.1 | 93.6 | 7.5 | 830 | 2015 | [88] | |
Tm:YAP | 0.89 | 35.8 | 0.481 | 1850 | 2015 | [71] | |
Tm,Ho:KLuW | 0.131 | 14 | 8.2 | 10.4 | 2016 | [77] | |
Cr:CdSe | Ho:YAG | 1.2 | 15.4 | 0.685 | 1766 | 2017 | [89] |
Overview of Cr2+-doped crystal modulated 2 μm solid-state lasers.
In conclusion, Cr2+ doped II-VI compounds have been successfully used as SAs in passively Q-switched 2 μm lasers. In this way, the obtained pulse energies and the pulse widths can reach hundreds of μJ and ns or even sub-ns level. The maximum pulse energy of 2.47 mJ, and the shortest pulses with sub-nanosecond (780 ps) duration were both realized with a kind of Cr:ZnS SA. Therefore, Cr2+ doped II-VI crystals are still irreplaceable SAs in generating passively Q-switched 2 μm lasers with pulse energies over mJ level and pulse width in order of several nanoseconds to sub-nanoseconds.
As mentioned above, the popular SAs used in the 2 μm Q-switched solid-state lasers are mainly low-dimensional nanomaterials and Cr-doped crystals. In addition, the absorption effect of Ho3+ doped gain crystals can also be used for SAs, which can be classified as a slow-relaxing solid-state SA due to possessing a long emission lifetime. However, the study of passively Q-switched solid-state lasers based on gain crystals is relatively rare. In 1994, Kuo et al. reported a flash-lamp pumped Tm,Cr:Y3Al5O12 laser using a Ho:YLiF4 as SA at room temperature [91]. A maximum single pulse energy of 11 mJ and a shortest pulse duration of 45 ns were obtained. It paved the way for Ho-doped crystals as SAs for passively Q-switched 2 μm lasers. Additionally, Ho:SSO has also been employed as an efficient SA. In 2018, a Ho:SSO crystal was used as SA for the Ho:YAG laser [92]. At a repetition rate of 42.1 kHz, a minimum pulsed duration of 48 ns and a maximum pulse energy of 2 mJ were obtained.
2 μm laser is an ideal light source for the medical application, which has less damage to the rest of the tissue, and less bleeding during the operation. 2 μm lasers used in laser medical treatment are mainly YAG-based two pulsed lasers [93, 94, 95, 96]. Ho:YAG has been successfully used in urology and orthopedics [96]. However, little is known about hard dental tissue ablation with Ho:YAG laser. For example, non-contact laser surgery offers several potential advantages in dental treatment, such as reduced pain and vibration, more precise control by electronic device and haemostatic effect. Figure 8 shows cross-sectional images of ablation crater created on the urinary calculi surface by pulsed Ho:YAG laser (Wuhan National Laboratory for Optoelectronics) in air (dry condition) and underwater with various thickness [93]. The pulsed Ho:YAG laser emitted at 2.12 μm with the pulse energy of 2000 mJ and the pulse duration of 300/450 μs at the repetition rate of 20 Hz.
(Color online) Cross-sectional topography of holmium laser-induced (300 μs, 300 mJ, 1 Hz) craters acquired with OCM system in air and in water. The 600 μm fiber is vertically in contact with the urinary calculi surface. w = width; h = height. [Reprinted/Adapted] With permission from Ref. [
Lidar technology is an optical remote sensing technology that acquires the physical information of a target object by detecting the scattered light characteristics of a distant target object. Compared with the traditional radar technology, the laser radar technology realizes the information loading by modulating the amplitude and frequency of the laser beam, thereby having the advantages of high resolution and good anti-interference. In recent years, laser radar technology with 2 μm band laser as coherent light source has been proposed and made some progress. In 2006, the NICT agency in Japan reported on the airborne coherent wind lidar system. The system used a Tm:YAG laser with a center wavelength of 2.01 μm as the coherent light source, and the maximum single pulse energy was 7 mJ, and it was successfully applied to the test of atmospheric wind profile [97]. In 2007, NASA agencies in the United States reported on the vehicle’s coherent wind Lidar system. The system utilized Tm,Ho:LuLiF4 laser at 2.05 μm and a pulse energy of 100 mJ as the coherent light source, and successfully detected the wind field information of the boundary layer and the troposphere [98]. In 2013, the NICT facility in Japan used a differential absorption Lidar system to successfully measure CO2 concentrations and mountain targets in the 7 km range. The system used a Ho:YLF laser as the light source with a pulse energy of 50–80 mJ and a pulse width of 150 ns at the repetition frequency of 30 Hz [99]. In 2014, the French Polytechnic University reported a Ho:YLF multi-frequency single longitudinal mode laser with a center wavelength of 2.051 μm. The laser operated at a repetition rate of 2 kHz with a pulse energy of 13 mJ and a pulse width of 42 ns. The laser could be used as a source of differential absorption Lidar for the measurement of atmospheric CO2 concentrations, as shown in Figure 9 [100].
Experimental setup diagram of differential absorption Lidar for the measurement of atmospheric CO2 concentrations based on 2 μm laser. (a) Offset locking between On and Off distributed-feedback laser diode (DFB), (b) seeding architecture, (c) cavity length locking using Pound-Drever-Hall technique (PDH), (d) 2-μm pulsed oscillator, and (e) characterization: power meter, beam profiler, heterodyne detection [
A pulsed 2 μm laser with high peak power is also a promising pump source for OPOs in the wavebands such as 3~5 and 8~12 μm. The laser in this waveband plays a key role in the directed infrared countermeasures. Compared with other mid-far infrared lasers (such as CO lasers [101, 102], quantum cascade lasers [103, 104]), OPOs have the advantages of wideband tunability of output spectrum and narrow laser line width. The typical system is Directed Infrared Countermeasures (DIRCM) system, which can protect airborne platforms from infrared guided missile threats. The layout of the Ho:YAG master oscillator power amplifier (MOPA) in DIRCM system [105]. A Tm:YLF fiber laser pumped Ho:YAG laser system with pulse energies up to 90 mJ and the pulse width of 20 ns at 100 Hz. Then, the wavelength was converted into the 3 to 5-micron region using a zinc germanium phosphide (ZGP) crystal in a linear or ring resonator.
In conclusion, 2 μm wave is located in the weak absorption band of the atmosphere and the safe region of the human eye. Therefore, it is of great significance to study 2 μm Q-switched lasers in the areas such as laser medicine and laser lidar. Moreover, the 2 μm pulse laser with high peak power can also be used as an efficient pump source for OPOs and OPA to obtain the output of mid- and far- infrared laser. With the development of 2 μm pulsed laser, it will have more broad applying foreground in industrial processing, medicine, and military field.
2 μm pulsed laser with stable, compact and cost-effective characteristics has been a hot topic in recent years. To achieve pulsed laser sources with large pulse energy and high peak power, the traditional method is based on actively AO or EO Q-switching technology. For the flash-pumping operation regime, it has great advantages in generating high energy laser output with hundreds of mJ level due to the larger mode area than that of diode-pumping case. However, diode-pumped solid-state 2 μm lasers have achieved rapid development because of the advantages such as high efficiency, small size, and high beam quality. Furthermore, in cased of the AO Q-switching, many excellent works have been done and the maximum single pulse energy ever achieved is 128 mJ. For diode-pumped EO Q-switched solid lasers, 550-mJ single pulse energy has set a record in the case of using a RTP crystal as EO modulator, to the best of our knowledge. Although the EO modulator has relatively good switching effect, suitable EO crystal with low driven voltage and high repetition rate is rare. Recently, a LGS crystal based EO Q-switched Tm:YAP laser with a maximum repetition rate of 200 kHz was reported, which indicated that the LGS crystal with high damage threshold could be a promising EO Q-switch. Compared with active Q-switching method, passive Q-switching technology has shown promising advantages, such as simplicity, compactness, and high repetition rate, although it usually works in low-energy regime. The most mature SAs are Cr2+ doped II-VI crystals which are still irreplaceable in generating passively Q-switched 2 μm laser with pulse energy over mJ level and pulse width in an order of several nanoseconds to sub-nanoseconds. Besides, the Ho3+ doped gain crystals can also be used as SAs for 2 μm solid-state lasers, however, this rarely employed method can only deliver tens of nanoseconds pulses with tens of kHz repetition rate. At present, the 2D nanomaterials based SAs have become hot spots in generating pulsed lasers due to its advantages of easy fabrication, compact setup, and broadband optical absorptions. However, the pulse energy was limited to μJ level determined by the low damage thresholds of the 2D material. At the same time, there is also a problem in fabricating high quality thin films with large area and uniform thickness. In the near future, active Q-switching technology would still be the main method in obtaining high pulse energy or short pulse width with excellent stability and controllability. Of course, more suitable EO crystals would be further explored. For SAs suitable for passively Q-switched lasers, novel kinds of 2D nanomaterials are emerging endlessly, and the preparation method for growing high quality 2D-SAs are coming to maturity.
As for the applications of Q-switched 2 μm lasers, the application fields are becoming broader and broader. When the 2 μm pulsed laser is applied on the tissue, it can generate the effects such as the vaporization, cutting, solidification, hemostasis and so on, so it plays an important role in medical surgery. Q-switched 2 μm lasers can also be effectively used in environmental monitoring and measurement of carbon dioxide, aerosol concentration, cloud layer and water vapor distribution in the atmosphere. Besides, it should be particularly stated that 2 μm pulsed laser with high peak power is an efficient pump source for OPOs or OPA to realize mid- and far- infrared laser sources, which have important applications in the fields such as Lidar, optoelectronic countermeasures, laser ranging and infrared guidance technology. With the continuous enhancement of Q-switched 2 μm laser performance, more complicated application fields would be further explored and developed in the future.
This work was partially supported by National Natural Science Foundation of China (NSFC) (61475088), Key research and development program of Shandong Province (2018GGX101006), Shenzhen Science and Technology Research and Development Funds (JCYJ20180305163932273), the Program of State Key Laboratory of Quantum Optics and Quantum Optics Devices (KF201908) and Young Scholars Program of Shandong University (2015WLJH38).
As an Open Access publisher, IntechOpen is dedicated to maintaining the highest ethical standards and principles in publishing. In addition, IntechOpen promotes the highest standards of integrity and ethical behavior in scientific research and peer-review. To maintain these principles IntechOpen has developed basic guidelines to facilitate the avoidance of Conflicts of Interest.
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\n\nIntechOpen requires:
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\n\nAvoidance Measures for Academic Editors of Conflicts of Interest:
\n\nFor manuscripts submitted by the Academic Editor (or a scientific advisor), an appropriate person will be appointed to handle and evaluate the manuscript. The appointed handling Editor's identity will not be disclosed to the Author in order to maintain impartiality and anonymity of the review.
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\n\nCONFLICT OF INTEREST - REVIEWER
\n\nAll Reviewers are required to declare possible Conflicts of Interest at the beginning of the evaluation process. If a Reviewer feels he or she might have any material, financial or any other conflict of interest with regards to the manuscript being reviewed, he or she is required to declare such concern and, if necessary, request exclusion from any further involvement in the evaluation process. A Reviewer's potential Conflicts of Interest are declared in the review report and presented to the Academic Editor, who then assesses whether or not the declared potential or actual Conflicts of Interest had, or could be perceived to have had, any significant impact on the review itself.
\n\nEXAMPLES OF CONFLICTS OF INTEREST:
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\n\nNON-FINANCIAL
\n\nAuthors are required to declare all potentially relevant non-financial, financial and material Conflicts of Interest that may have had an influence on their scientific work.
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\n\nAcademic Editors should declare if the Author of a submitted manuscript is affiliated with the same department, faculty, institute, or company as they are.
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De Oliveira, D.A.C. Albuquerque, T.G.S. Cruz, F.M. Yamaji and F.L. Leite",authors:[{id:"1164",title:"Dr.",name:"Fabio",middleName:"Lima",surname:"Leite",slug:"fabio-leite",fullName:"Fabio Leite"},{id:"136651",title:"MSc.",name:"Ricardo",middleName:null,surname:"De Oliveira",slug:"ricardo-de-oliveira",fullName:"Ricardo De Oliveira"},{id:"136652",title:"M.Sc.",name:"Diego",middleName:"Aparecido Carvalho",surname:"Albuquerque",slug:"diego-albuquerque",fullName:"Diego Albuquerque"},{id:"136653",title:"Prof.",name:"Tersio",middleName:null,surname:"Cruz",slug:"tersio-cruz",fullName:"Tersio Cruz"},{id:"136657",title:"Prof.",name:"Fabio",middleName:null,surname:"Yamaji",slug:"fabio-yamaji",fullName:"Fabio Yamaji"}]},{id:"49054",doi:"10.5772/60952",title:"Anion Exchange Resins as Effective Sorbents for Removal of Acid, Reactive, and Direct Dyes from Textile Wastewaters",slug:"anion-exchange-resins-as-effective-sorbents-for-removal-of-acid-reactive-and-direct-dyes-from-textil",totalDownloads:3188,totalCrossrefCites:24,totalDimensionsCites:47,abstract:"Coloured wastewaters are a consequence of batch processes in both dye-manufacturing and dye-consuming industries. Dyes are widely used in a number of industries, such as textile and leather dyeing, food, cosmetics, paper printing, gasoline, with the textile industry as the largest consumer. Dyeing as a fundamental operation during textile fibre processing causes the production of more or less coloured wastewaters, depending on the degree of fixation of dyes on substrates, which varies with the nature of substances, desired intensity of coloration, and application method. Dye bearing effluents are considered to be a very complex and inconsistent mixture of many pollutants ranging from dyes, dressing substances, alkalis, oils, detergents, salts of organic and inorganic acids to heavy metals.Thus after dyeing wastewaters are characterized not only by intensive and difficult for removal colour but also by high pH, suspended and dissolved solids, chemical and biochemical oxygen demands. Ion exchange is a very versatile and effective tool for treatment of aqueous hazardous wastes including dyes. The role of ion exchange in dye effluents treatment is to reduce the magnitude of hazardous load by converting them into a form in which they can be reused, leaving behind less toxic substances in their places or to facilitate ultimate disposal by reducing the hydraulic flow of the stream bearing toxic substances. Another significant feature of the ion exchange process is that it has the ability to separate as well as to concentrate pollutants. Taking into account high capacity and selectivity of ion exchange resins for different dyes, they seem to be proper materials for dyes sorption from textile effluents. The aim of the paper is to study the removal of the acid, reactive and direct textile dyes such as C.I. Acid Orange 7, C.I. Reactive Black 5 and C.I. Direct Blue 71 on the commercially available anion exchangers (Lewatit MonoPlus MP 62, Lewatit MonoPlus MP 64, Lewatit MonoPlus MP 500, Lewatit MonoPlus M 500, Amberlite IRA 67, Amberlite IRA 478RF, Amberlite IRA 458 and Amberlite IRA 958) differing not only in basicity of the functional groups but also in composition and structure of the matrix. Comparison of the sorption parameters obtained by the batch method taking into account influence of phase contact time, dyes initial concentration and solution pH were discussed in detail. Desorption conditions depending on the dyes sorption mechanism were also presented. Influence of the auxiliaries typically present in textile effluents such as inorganic electrolytes and different surfactants on the amounts of dyes retained by the anion exchangers was presented. The adsorption behaviour of the polyacrylic Amberlite IRA 958 demonstrates that it can be a promising adsorbent for the textile wastewater treatment. The results obtained with raw textile wastewaters purification confirmed this statement.",book:{id:"4599",slug:"ion-exchange-studies-and-applications",title:"Ion Exchange",fullTitle:"Ion Exchange - Studies and Applications"},signatures:"Monika Wawrzkiewicz and Zbigniew Hubicki",authors:[{id:"141883",title:"Prof.",name:"Zbigniew",middleName:null,surname:"Hubicki",slug:"zbigniew-hubicki",fullName:"Zbigniew Hubicki"},{id:"173310",title:"Dr.",name:"Monika",middleName:null,surname:"Wawrzkiewicz",slug:"monika-wawrzkiewicz",fullName:"Monika Wawrzkiewicz"}]},{id:"52110",doi:"10.5772/64935",title:"Electrodeposition from Deep Eutectic Solvents",slug:"electrodeposition-from-deep-eutectic-solvents",totalDownloads:3488,totalCrossrefCites:7,totalDimensionsCites:29,abstract:"Deep eutectic solvents constitute a class of compounds sharing many similarities with properly named ionic liquids. The accepted definition of ionic liquid is a fluid (liquid for T<100 °C) consisting of ions, while DES are eutectic mixtures of Lewis or Brønsted acids and bases. Their most attractive properties are the wide potential windows and the chemical properties largely different from aqueous solutions. In the last few decades, the possibility to electrodeposit decorative and functional coatings employing deep eutectic solvents as electrolytes has been widely investigated. A large number of the deposition procedures described in literature, however, cannot find application in the industrial practice due to competition with existing processes, cost or difficult scalability. From one side, there is the real potential to replace existing plating protocols and to find niche applications for high added-value productions; to the other one, this paves the path towards the electrodeposition of metals and alloys thermodynamically impossible to be obtained via usual aqueous solution processes. The main aim of this chapter is therefore the critical discussion of the applicability of deep eutectic solvents to the electrodeposition of metals and alloys, with a particular attention to the industrial and applicative point of view.",book:{id:"5381",slug:"progress-and-developments-in-ionic-liquids",title:"Ionic Liquids",fullTitle:"Progress and Developments in Ionic Liquids"},signatures:"R. Bernasconi, G. Panzeri, A. Accogli, F. Liberale, L. Nobili and L.\nMagagnin",authors:[{id:"188210",title:"Associate Prof.",name:"Luca",middleName:null,surname:"Magagnin",slug:"luca-magagnin",fullName:"Luca Magagnin"},{id:"194387",title:"MSc.",name:"Roberto",middleName:null,surname:"Bernasconi",slug:"roberto-bernasconi",fullName:"Roberto Bernasconi"},{id:"194388",title:"MSc.",name:"Gabriele",middleName:null,surname:"Panzeri",slug:"gabriele-panzeri",fullName:"Gabriele Panzeri"},{id:"194389",title:"MSc.",name:"Alessandra",middleName:null,surname:"Accogli",slug:"alessandra-accogli",fullName:"Alessandra Accogli"},{id:"194390",title:"MSc.",name:"Francesco",middleName:null,surname:"Liberale",slug:"francesco-liberale",fullName:"Francesco Liberale"},{id:"194391",title:"Prof.",name:"Luca",middleName:null,surname:"Nobili",slug:"luca-nobili",fullName:"Luca Nobili"}]},{id:"25422",doi:"10.5772/28293",title:"Electrochemical Polymerization of Aniline",slug:"electrochemical-polymerization-of-aniline",totalDownloads:11463,totalCrossrefCites:3,totalDimensionsCites:29,abstract:null,book:{id:"607",slug:"electropolymerization",title:"Electropolymerization",fullTitle:"Electropolymerization"},signatures:"Milica M. Gvozdenović, Branimir Z. Jugović, Jasmina S. Stevanović, Tomislav Lj. Trišović and Branimir N. Grgur",authors:[{id:"73400",title:"Dr.",name:"Milica",middleName:null,surname:"Gvozdenović",slug:"milica-gvozdenovic",fullName:"Milica Gvozdenović"},{id:"78801",title:"Dr.",name:"Branimir",middleName:null,surname:"Jugović",slug:"branimir-jugovic",fullName:"Branimir Jugović"},{id:"78807",title:"Dr.",name:"Jasmina",middleName:null,surname:"Stevanović",slug:"jasmina-stevanovic",fullName:"Jasmina Stevanović"},{id:"120374",title:"Dr.",name:"Tomislav",middleName:null,surname:"Trišović",slug:"tomislav-trisovic",fullName:"Tomislav Trišović"},{id:"120376",title:"Prof.",name:"Branimir",middleName:null,surname:"Grgur",slug:"branimir-grgur",fullName:"Branimir Grgur"}]}],mostDownloadedChaptersLast30Days:[{id:"52110",title:"Electrodeposition from Deep Eutectic Solvents",slug:"electrodeposition-from-deep-eutectic-solvents",totalDownloads:3487,totalCrossrefCites:7,totalDimensionsCites:29,abstract:"Deep eutectic solvents constitute a class of compounds sharing many similarities with properly named ionic liquids. The accepted definition of ionic liquid is a fluid (liquid for T<100 °C) consisting of ions, while DES are eutectic mixtures of Lewis or Brønsted acids and bases. Their most attractive properties are the wide potential windows and the chemical properties largely different from aqueous solutions. In the last few decades, the possibility to electrodeposit decorative and functional coatings employing deep eutectic solvents as electrolytes has been widely investigated. A large number of the deposition procedures described in literature, however, cannot find application in the industrial practice due to competition with existing processes, cost or difficult scalability. From one side, there is the real potential to replace existing plating protocols and to find niche applications for high added-value productions; to the other one, this paves the path towards the electrodeposition of metals and alloys thermodynamically impossible to be obtained via usual aqueous solution processes. The main aim of this chapter is therefore the critical discussion of the applicability of deep eutectic solvents to the electrodeposition of metals and alloys, with a particular attention to the industrial and applicative point of view.",book:{id:"5381",slug:"progress-and-developments-in-ionic-liquids",title:"Ionic Liquids",fullTitle:"Progress and Developments in Ionic Liquids"},signatures:"R. Bernasconi, G. Panzeri, A. Accogli, F. Liberale, L. Nobili and L.\nMagagnin",authors:[{id:"188210",title:"Associate Prof.",name:"Luca",middleName:null,surname:"Magagnin",slug:"luca-magagnin",fullName:"Luca Magagnin"},{id:"194387",title:"MSc.",name:"Roberto",middleName:null,surname:"Bernasconi",slug:"roberto-bernasconi",fullName:"Roberto Bernasconi"},{id:"194388",title:"MSc.",name:"Gabriele",middleName:null,surname:"Panzeri",slug:"gabriele-panzeri",fullName:"Gabriele Panzeri"},{id:"194389",title:"MSc.",name:"Alessandra",middleName:null,surname:"Accogli",slug:"alessandra-accogli",fullName:"Alessandra Accogli"},{id:"194390",title:"MSc.",name:"Francesco",middleName:null,surname:"Liberale",slug:"francesco-liberale",fullName:"Francesco Liberale"},{id:"194391",title:"Prof.",name:"Luca",middleName:null,surname:"Nobili",slug:"luca-nobili",fullName:"Luca Nobili"}]},{id:"74147",title:"Electrochemical Impedance Spectroscopy (EIS): A Review Study of Basic Aspects of the Corrosion Mechanism Applied to Steels",slug:"electrochemical-impedance-spectroscopy-eis-a-review-study-of-basic-aspects-of-the-corrosion-mechanis",totalDownloads:2662,totalCrossrefCites:11,totalDimensionsCites:21,abstract:"AC impedance measurements have been applied for over twenty years in electrochemistry and physics to investigate the electrical properties of conductive materials and their interfaces using an external electrical impulse (VOLTAGE, V or CURRENT, I) as driving force. Furthermore, its application has recently appeared to be destined in the Biotechnology field as an effective tool for rapid microbiologic diagnosis of living organism in situ. However, there is no doubt that the electrochemical impedance spectroscopy (EIS) is still one of the most useful techniques around the world for metal corrosion control and its monitoring. Corrosion has long been recognized as one of the most expensive stumbling blocks that concern many industries and government agencies, because it is a steel destructive phenomenon that occurs due to the chemical interaction with aqueous environments and takes place at the interface between metal and electrolyte producing an electrical charge transfer or ion diffusion process. Consequently, it is experimentally possible to determine through the EIS technique the mechanism and control that kinectics of corrosion reactions encounter. First, EIS data is collected through a potentiostat/galvanostat apparatus. After, it is fitted to a mathematical model (i.e. an equivalent electrical circuit, EEC) for its interpretation and analysis, fundamentally seeking a meaningful physical interpretation. Finally, this review reports some basic aspects of the corrosion mechanism applied to steels through the experimental EIS response using Nyquist or Bode plots. Examples are given for different applied electrochemical impedance cases in which steel is under study intentionally exposed to a corrosive aqueous solution by applying a sinusoidal potential at various test conditions.",book:{id:"10054",slug:"electrochemical-impedance-spectroscopy",title:"Electrochemical Impedance Spectroscopy",fullTitle:"Electrochemical Impedance Spectroscopy"},signatures:"Héctor Herrera Hernández, Adriana M. Ruiz Reynoso, Juan C. Trinidad González, Carlos O. González Morán, José G. Miranda Hernández, Araceli Mandujano Ruiz, Jorge Morales Hernández and Ricardo Orozco Cruz",authors:[{id:"114381",title:"Dr.",name:"Jorge",middleName:null,surname:"Morales-Hernandez",slug:"jorge-morales-hernandez",fullName:"Jorge Morales-Hernandez"},{id:"215540",title:"Dr.",name:"Araceli",middleName:null,surname:"Mandujano Ruiz",slug:"araceli-mandujano-ruiz",fullName:"Araceli Mandujano Ruiz"},{id:"268773",title:"Dr.",name:"Hector",middleName:null,surname:"Herrera Hernandez",slug:"hector-herrera-hernandez",fullName:"Hector Herrera Hernandez"},{id:"268774",title:"Dr.",name:"Carlos O.",middleName:null,surname:"Gonzalez Moran",slug:"carlos-o.-gonzalez-moran",fullName:"Carlos O. Gonzalez Moran"},{id:"314695",title:"Dr.",name:"Adriana Mercedes",middleName:null,surname:"Ruiz Reynoso",slug:"adriana-mercedes-ruiz-reynoso",fullName:"Adriana Mercedes Ruiz Reynoso"}]},{id:"62242",title:"Oxygen Reduction Reaction",slug:"oxygen-reduction-reaction",totalDownloads:4028,totalCrossrefCites:8,totalDimensionsCites:18,abstract:"In this chapter, the oxygen reduction reaction (ORR), which is one of the most important reactions in energy conversion systems such as fuel cells, including its reaction kinetics, is presented. Recent developments in electrocatalysts for ORR in fuel cells, including low and non-Pt electrocatalysts, metal oxides, transition metal macrocycles and chalgogenides, are discussed. Understanding of the interdependence of size, shape and activity of the electrocatalysts is evaluated. The recent development of ORR electrocatalysts with novel nanostructures is also reported. The mechanism catalysed by these electrocatalysts is presented. Finally, the perspectives of future trends for ORR are discussed.",book:{id:"6778",slug:"electrocatalysts-for-fuel-cells-and-hydrogen-evolution-theory-to-design",title:"Electrocatalysts for Fuel Cells and Hydrogen Evolution",fullTitle:"Electrocatalysts for Fuel Cells and Hydrogen Evolution - Theory to Design"},signatures:"Lindiwe Khotseng",authors:[{id:"236596",title:"Dr.",name:"Lindiwe Eudora",middleName:null,surname:"Khotseng",slug:"lindiwe-eudora-khotseng",fullName:"Lindiwe Eudora Khotseng"}]},{id:"40709",title:"The Role of Ion Exchange Chromatography in Purification and Characterization of Molecules",slug:"the-role-of-ion-exchange-chromatography-in-purification-and-characterization-of-molecules",totalDownloads:12954,totalCrossrefCites:2,totalDimensionsCites:9,abstract:null,book:{id:"2549",slug:"ion-exchange-technologies",title:"Ion Exchange Technologies",fullTitle:"Ion Exchange Technologies"},signatures:"Hidayat Ullah Khan",authors:[{id:"140538",title:"Dr.",name:"Hidayat",middleName:null,surname:"Khan",slug:"hidayat-khan",fullName:"Hidayat Khan"}]},{id:"49055",title:"Ion Exchange Method for Removal and Separation of Noble Metal Ions",slug:"ion-exchange-method-for-removal-and-separation-of-noble-metal-ions",totalDownloads:3029,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"Ion exchange has been widely applied in technology of chemical separation of noble metal ions. This is associated with dissemination of methods using various ion exchange resins which are indispensable in many fields of chemical industry. Due to small amounts of noble elements in nature and constant impoverishment of their natural raw materials, of particular importance are physicochemical methods of their recovery from the second sources e.g. worn out converters of exhausted gases, chemical catalysts, dental alloys, anodic sludges from cooper and nickiel electrorefining as well as waste waters and running off waters from refineries containing trace amount of noble metals. It should be stated that these waste materials are usually pyro- and hydrometallurgically processed. Recovery of noble metals, from such raw materials requires individual approach to each material and application of selective methods for their removal. Moreover, separation of noble metals, particularly platinum metals and gold from geological samples, industrial products, synthetic mixtures along with other elements is a problem of significant importance nowadays. In the paper the research on the applicability of different types of ion exchangers for the separation of noble metals will be presented. The effect of the different parameters on their separation will be also discussed. The examples of the removal of noble metals chlorocomplexes will also be presented in detail.",book:{id:"4599",slug:"ion-exchange-studies-and-applications",title:"Ion Exchange",fullTitle:"Ion Exchange - Studies and Applications"},signatures:"Zbigniew Hubicki, Monika Wawrzkiewicz, Grzegorz Wójcik, Dorota\nKołodyńska and Anna Wołowicz",authors:[{id:"141883",title:"Prof.",name:"Zbigniew",middleName:null,surname:"Hubicki",slug:"zbigniew-hubicki",fullName:"Zbigniew Hubicki"},{id:"173610",title:"Dr.",name:"Dorota",middleName:null,surname:"Kołodyńska",slug:"dorota-kolodynska",fullName:"Dorota Kołodyńska"}]}],onlineFirstChaptersFilter:{topicId:"505",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:20,paginationItems:[{id:"82526",title:"Deep Multiagent Reinforcement Learning Methods Addressing the Scalability Challenge",doi:"10.5772/intechopen.105627",signatures:"Theocharis Kravaris and George A. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:303,paginationItems:[{id:"280338",title:"Dr.",name:"Yutaka",middleName:null,surname:"Tsutsumi",slug:"yutaka-tsutsumi",fullName:"Yutaka Tsutsumi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/280338/images/7961_n.jpg",biography:null,institutionString:null,institution:{name:"Fujita Health University",country:{name:"Japan"}}},{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"117248",title:"Dr.",name:"Andrew",middleName:null,surname:"Macnab",slug:"andrew-macnab",fullName:"Andrew Macnab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337443",title:"Dr.",name:"Juan",middleName:null,surname:"A. Gonzalez-Sanchez",slug:"juan-a.-gonzalez-sanchez",fullName:"Juan A. 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The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. 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Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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