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Subrata Dey

West Bengal University of Technology

Prof. Subrata Dey received his Ph.D. degree from the University of Kalyani, India. He joined the faculty of Maulana Abul Kalam Azad University of Technology (formerly known as West Bengal University of Technology) as Professor of Biotechnology in 2005. His laboratory has long been involved in research on the molecular genetics of Down syndrome and other congenital disorders, the genetics of Alzheimer’s disease, the genetics of congenital heart disease, radiation-induced genomic instability, radioprotection and stem cell biology. Prof. Dey received a Golden Jubilee Award for excellence in teaching and research. He has published more than 80 research papers in referred journals, edited five books on Down syndrome and has completed eleven research projects funded by the Government Of India. Several students also received their Ph.D. under his supervision. Along with teaching and research, Prof. Dey has handled a number of administrative assignments successfully and made dedicated and innovative approaches with great integrity. Major administrative roles were Director of School of Biotechnology and Biological Sciences, Founder Co-ordinator of Centre for Genetic Studies, Member-Coordinator of Ekta Incubation Centre, Pro-Vice Chancellor and Vice-Chancellor of Maulana Abul Kalam Azad University of Technology, Vice Chancellor of Brainware University. Recently he joined as Vice Chancellor of Swami Vivekananda University, West Bengal, India.

5books edited

4chapters authored

Latest work with IntechOpen by Subrata Dey

This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on chromosome editing, neurogenomics and diseases associated with Down syndrome. Research workers, scientists, medical graduates and physicians will find this book as an excellent source for consultation and references. Key features of this book are chromosome engineering in Down syndrome, mental retardation and cognitive disability, prenatal diagnosis and diseases associated with Down syndrome. Although aimed primarily for research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be exciting to wider audience, especially parents, relatives and health care providers who work with infants and children with Down syndrome.

Advances in Research on Down SyndromeEdited by Subrata Dey

Advances in Research on Down Syndrome

Edited by Subrata Dey

Books edited

Health Problems in Down SyndromeEdited by Subrata Dey

Health Problems in Down Syndrome

Edited by Subrata Dey

Down SyndromeEdited by Subrata Dey

Down Syndrome

Edited by Subrata Dey

Genetics and Etiology of Down SyndromeEdited by Subrata Dey

Genetics and Etiology of Down Syndrome

Edited by Subrata Dey

Prenatal Diagnosis and Screening for Down SyndromeEdited by Subrata Dey

Prenatal Diagnosis and Screening for Down Syndrome

Edited by Subrata Dey

Chapters authored

Etiology of Down Syndrome: Risk of Advanced Maternal Age and Altered Meiotic Recombination for Chromosome 21 Nondisjunction

By Subrata Kumar Dey and Sujoy Ghosh

Part of the book: Genetics and Etiology of Down Syndrome

Risk Factors for Down Syndrome Birth: Understanding the Causes from Genetics and Epidemiology

By Sujay Ghosh and Subrata Kumar Dey

Part of the book: Down Syndrome

Recent Advances in Research on Down Syndrome

By Poulami Majumder, Pranami Bhaumik, Priyanka Ghosh, Mandar Bhattacharya, Sujoy Ghosh and Subrata Kumar Dey

Down syndrome (DS) or trisomy 21 is one of the most important genetic causes of mental retardation. Sincere and significant attempts have been made towards understanding the congenital diseases that affect DS patients. Better understanding of gene networks associated with such malformations will help to predict the complex genetic trait behind congenital disease in DS and will also provide the basis for tailored gene therapies that could begin to heal or prevent such malformation without the need to resort to invasive surgery. Further, susceptible mutation screening in women will also be helpful for both prenatal diagnosis of DS birth and assessing the risk of predisposition to Alzheimer’s disease and congenital heart disease. Stress condition and neurodegeneration are two important markers in Down syndrome patients and mtDNA variation can also be used as an important biomarker. It has been suggested that nutraceuticals which reduce reactive oxygen species (ROS) level may be used to treat trisomy 21 condition. As mitochondria play a crucial role in the regulation of free radicals, only a detail analysis will reveal the origin of phenotypic characteristics among trisomy 21 DS patients. On the other hand, several mechanisms are responsible for neurodegeneration as well as altered cognition. It includes impaired neurogenesis leading to hypocellularity in the cortex, hippocampus and cerebellum, altered dendritic morphology, altered synapses, increased inhibition and neurodegeneration. The new knowledge of the pathogenic mechanisms in DS individuals has been acquired from mouse model. These studies provide the basis for developing new drugs for clinical trials in DS individuals and to sustain the hope that some of these drugs will be useful in treating intellectual disability in DS individuals.

Part of the book: Health Problems in Down Syndrome

Impact of Biological Factors Related to Maternal Aging: Risk of Childbirth with Down Syndrome

By Subrata Kumar Dey, Pranami Bhaumik and Mandar Bhattacharya

Maternal aging and different biological factors play an important role in the birth of Down syndrome baby. Hormones play a crucial role for the maintenance of female sex cycle and oocyte maturation. Disparity in the level of these hormones during menstrual cycle has profound effect on female reproductive system. Hormonal imbalance also affects meiotic process and integrity of spindle structure and leads to nondisjunction of chromosome. Follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH) and luteinizing hormone (LH) play a crucial role in ovarian aging and nondisjunction of chromosomes. FSH stands as a hormonal indicator for ovarian aging, and its high level is responsible for aneuploid birth. Advanced chronological age of mother, ovarian aging, environmental factors and accelerated telomere shortening at older reproductive age are found to be risk factors for the birth of trisomy 21 Down syndrome.

Part of the book: Chromosomal Abnormalities

Related collaborators

Thomas Eggermann

RWTH Aachen University, Germany

Randall J. Roper

Érika Cristina Pavarino

Gesa Schwanitz

Volney Sheen

Samantha L. Deitz

Joshua D. Blazek

Jeffrey P. Solzak

Jie Lu

Beth Israel Deaconess Medical Center, United States of America

Sujoy Ghosh

University of Calcutta