Subrata Dey

West Bengal University of Technology

Dr. Subrata Dey is the Professor of Biotechnology and Ex-Vice Chancellor of the West Bengal University of Technology(Presently named as Maulana Abul Kalam Azad University of Technology). Prof. Dey has long been associated with research on the molecular genetics of Down syndrome and has worked extensively on the etiology of Down syndrome. His current research interests include the identification of genes involved in congenital heart disease, Alzheimer’s disease in both Down syndrome and normal individuals. Dr. Dey has been teaching courses in Genetics, Molecular Biology& Developmental Biology for more than thirty years and has received an award for academic excellence. He is also the founding Director of Centre for Genetic Studies. Prof. Dey is the author of many scientific papers and has edited four books on Down syndrome.

5books edited

4chapters authored

Latest work with IntechOpen by Subrata Dey

This book provides a concise yet comprehensive source of current information on Down syndrome. Research workers, scientists, medical graduates and paediatricians will find it an excellent source for reference and review. This book has been divided into four sections, beginning with the Genetics and Etiology and ending with Prenatal Diagnosis and Screening. Inside, you will find state-of-the-art information on: 1. Genetics and Etiology 2. Down syndrome Model 3. Neurologic, Urologic, Dental & Allergic disorders 4. Prenatal Diagnosis and Screening Whilst aimed primarily at research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially parents and relatives of Down syndrome patients.

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Genetics and Etiology of Down SyndromeEdited by Subrata Dey

By Subrata Kumar Dey and Sujoy Ghosh

Part of the book: Genetics and Etiology of Down Syndrome

Risk Factors for Down Syndrome Birth: Understanding the Causes from Genetics and Epidemiology

By Sujay Ghosh and Subrata Kumar Dey

Part of the book: Down Syndrome

Recent Advances in Research on Down Syndrome

By Poulami Majumder, Pranami Bhaumik, Priyanka Ghosh, Mandar Bhattacharya, Sujoy Ghosh and Subrata Kumar Dey

Down syndrome (DS) or trisomy 21 is one of the most important genetic causes of mental retardation. Sincere and significant attempts have been made towards understanding the congenital diseases that affect DS patients. Better understanding of gene networks associated with such malformations will help to predict the complex genetic trait behind congenital disease in DS and will also provide the basis for tailored gene therapies that could begin to heal or prevent such malformation without the need to resort to invasive surgery. Further, susceptible mutation screening in women will also be helpful for both prenatal diagnosis of DS birth and assessing the risk of predisposition to Alzheimer’s disease and congenital heart disease. Stress condition and neurodegeneration are two important markers in Down syndrome patients and mtDNA variation can also be used as an important biomarker. It has been suggested that nutraceuticals which reduce reactive oxygen species (ROS) level may be used to treat trisomy 21 condition. As mitochondria play a crucial role in the regulation of free radicals, only a detail analysis will reveal the origin of phenotypic characteristics among trisomy 21 DS patients. On the other hand, several mechanisms are responsible for neurodegeneration as well as altered cognition. It includes impaired neurogenesis leading to hypocellularity in the cortex, hippocampus and cerebellum, altered dendritic morphology, altered synapses, increased inhibition and neurodegeneration. The new knowledge of the pathogenic mechanisms in DS individuals has been acquired from mouse model. These studies provide the basis for developing new drugs for clinical trials in DS individuals and to sustain the hope that some of these drugs will be useful in treating intellectual disability in DS individuals.

Part of the book: Health Problems in Down Syndrome

Impact of Biological Factors Related to Maternal Aging: Risk of Childbirth with Down Syndrome

By Subrata Kumar Dey, Pranami Bhaumik and Mandar Bhattacharya

Maternal aging and different biological factors play an important role in the birth of Down syndrome baby. Hormones play a crucial role for the maintenance of female sex cycle and oocyte maturation. Disparity in the level of these hormones during menstrual cycle has profound effect on female reproductive system. Hormonal imbalance also affects meiotic process and integrity of spindle structure and leads to nondisjunction of chromosome. Follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH) and luteinizing hormone (LH) play a crucial role in ovarian aging and nondisjunction of chromosomes. FSH stands as a hormonal indicator for ovarian aging, and its high level is responsible for aneuploid birth. Advanced chronological age of mother, ovarian aging, environmental factors and accelerated telomere shortening at older reproductive age are found to be risk factors for the birth of trisomy 21 Down syndrome.

Part of the book: Chromosomal Abnormalities

Subrata Dey

Latest work with IntechOpen by Subrata Dey

Genetics and Etiology of Down Syndrome

Books edited

Prenatal Diagnosis and Screening for Down Syndrome

Down Syndrome

Health Problems in Down Syndrome

Advances in Research on Down Syndrome

Chapters authored

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