\r\n\tThe WHO classification in 2007; was based on the histogenesis and cell origin of the tumor. In the latest classification made in 2016; to better characterize the tumor and obtain better data on its prognosis; The combination of molecular and genetic biomarkers and histopathological features of the tumor was used. Despite all current treatment approaches, the median survival time is around 12 months in most GBM patients. Compared with the situation of some types of successfully treated cancers; the survival time of GBM patients is not at an acceptable level today. In the treatment of CNS tumors; surgery, chemotherapy, and radiation treatments (x-rays, gamma rays, electron and proton beams) are used. The therapeutic potential of chemotherapy; New strategies are needed to increase drug concentration at the diseased site, as this largely depends on the ability of the chemotherapeutic agent to achieve effective concentrations at tumor localization. Based on our better understanding of the genetic and molecular characteristics of CNS tumors; Targeted therapies, including vaccines, and treatment protocols such as immunotherapy are promising developments.
\r\n\r\n\tThis book supposes to be written by many authors who have an internationally honored place in their field to share their ideas about the treatment of CNS tumors. Surgery, Radiotherapy, Chemotherapy and Antiangiogenic Therapy Protocols, Immunotherapy, Molecular Therapy, Specific target-agents therapy with Nanoparticles and Gene Therapy for CNS tumors among the book chapters.
\r\n\tIn these sections; there are many practical pieces of information that can help the students who graduated from the Medicine Faculty and specialist doctors who are interested in Neurosurgery.
Diabetes mellitus (DM) is a growing metabolic health problem, and around 346 million people are currently affected by diabetes worldwide, and it is anticipated to double by 2030 [http://www.who.int/mediacentre/factsheets/fs312/en/index.html]. Macro and microvascular complications are the major cause of morbidity and mortality in patients with type 2 diabetes [1]. The important pathology associated with vascular diseases is the formation and accumulation of atherosclerotic plaques leading to the process of atherosclerosis, which ultimately results in the narrowing of the blood vessels [2].
Vascular endothelial cells (ECs) are monolayers of cells that line the inner surface of the luminal vessel wall. It acts as a physical barrier between the bloodstream and the luminal wall [3, 4]. The term endothelial cell dysfunction (ECD) is referred to as loss/dysregulation of EC cells function: such as impairment of the barrier function, reduction of the anti-coagulants, disturbance in the balance between the vasodilation and vasoconstrictions, increased pro-inflammatory response, attachment, and adhesion of leukocytes to the endothelial cell surface, increase the production of pro-oxidant molecules [5, 6]. These points highlight the importance of ECs in maintaining normal vascular homeostasis.
During endothelial injury, oxidized lipids and protein adducts (advanced glycation end products) accumulate in the arterial walls. Then the circulating monocytes adhere to the endothelial cells that express adhesion molecules, such as vascular adhesion molecule-1 (VCAM-1) and selectins, and then migrate into the sub-endothelial space. These monocytes that infiltrate the arterial wall get differentiated into macrophages, and this macrophage also accumulates oxidized lipids to form foam cells. Then the foam cells attract the T-lymphocytes, which in turn induce the proliferation of smooth muscle cells in arterial walls. The entire process leads to the formation of a lipid-rich atherosclerotic lesion and rupture of this lesion leads to vascular infarction. Additionally, increased platelet aggregation and coagulation are also observed due to impaired nitric oxide generation, free-radical generation from the platelet, and elevated levels of plasminogen activator inhibitor. All these factors contribute to the vascular wall occlusion and further increase the risk of cardiovascular events as shown in Figure 1 [2, 7].
Mechanism of AGEs-induced oxidative stress in the formation of atherosclerotic plaque.
Numerous studies have demonstrated the existence of an association between elevated AGE levels and cardiovascular disease in DM patients. In line with this, clinical studies reported that CML and pentosidine levels are increased in the progression of the disease and act as a predictor of cardiovascular events [8, 9, 10, 11, 12, 13, 14]. A fourfold increase in the incidence of coronary artery disease, a 10-fold increase in peripheral vascular disease and a 3–4-fold higher mortality rate with as much as 75% of diabetics ultimately dying from vascular disease have been reported [15].
Vascular complications are classified into two types, namely macrovascular and microvascular. Wherein the large vessels such as arteries and veins get affected in macrovascular disease and microvascular involves small vessels such as capillaries. Chronic hyperglycemia initiates the production of AGE and turns on diabetic vascular complications through elevated production of reactive oxygen species, which instigates various signaling cascades such as Receptor for advanced glycation end product receptor (RAGE) activation, protein kinase C (PKC) and Mitogen activated protein kinases (MAPK) pathways. Macrovascular complications associated with diabetes are arteriosclerotic cardiovascular diseases (ASCVDs) such as coronary heart disease (CHD), peripheral artery disease (PAD), and stroke [2]. Microvascular complications associated with diabetes are diabetic retinopathy (DR), neuropathy, and nephropathy [16, 17] as shown in Figure 2.
AGEs-induced macrovascular and microvascular complications.
The pathogenic mechanisms underlying diabetic nephropathy involve the generation of reactive oxygen species (ROS), accumulation of AGEs, and activation of intracellular signaling molecules such as PKC [18, 19]. Studies suggest that increased formation of AGEs in the vitreous may be involved in the development of diabetic retinopathy by inducing the production of interleukins −6 (IL-6) from retinal Müller cells [20]. AGEs interaction RAGE plays an important role in the pathogenesis of DR [21]. In DR, AGEs (both early and late Amadori products) have been localized to vascular cells (endothelial and pericytes), neurons, glia, and also in the vitreous [22, 23]. Pentosidine and Nε-(carboxymethyl)lysine (CML) levels are increased in aqueous, vitreous, and serum of DR patients when compared with non-diabetic controls especially increased in proliferative DR (PDR) patients than non-proliferative DR (NPDR) and referred to as biomarker for microvascular complications [24, 25] with the progression of DR with decreased visual acuity, emphasizing that AGEs are novel biomarkers/risk markers for type 2 DR [26, 27]. In addition to the above AGEs, methylglyoxal derivative hydroimidazolone was also increased in DR patients [28, 29].
AGEs are a heterogeneous group of compounds generated by non-enzymatic glycation of proteins or lipids with glucose through Amadori rearrangement and its accumulation increases with aging and in diabetes [30]. The term AGEs has been applied to a broad range of advanced glycation end products such as CML, Nε-(carboxymethyl)hydroxylysine, pyrraline, and pentosidine [31]. Among these, CML is the predominant epitope in the AGE adducts detected in tissue proteins of diabetic patients [32, 33, 34]. Its level is found to be increased in serum and aqueous humor of type 2 diabetic patients with retinopathy (DR) [2]. It is also used as a biomarker to predict the progression of different stages of DR. AGEs-stimulated cell response is initiated by its engagement with the receptors present on the cell surface [35]. The most studied AGE receptor is RAGE. Several other AGE receptors identified so far consist of AGE-receptor complex (AGER1/OST-48, AGER2/80 K-H, AGER3/Gal-3), some members of the Toll-like Receptor (TLRs) family (TLR4, TLR2), and scavenging receptors (SRs) family (SR-AI, SR-AII, CD36, LOX-1, FEEL-1, and FEEL-2). The expression of these AGE-activated receptors depends on the cell/tissue type [36].
RAGE and TLRs are well-known Pattern Recognition Receptors (PRRs), which recognize molecules found in pathogens (Pathogen-Associated Molecular Patterns–PAMPs, ex-LPS) or molecules released from damaged or stressed cells such as high mobility group B (HMGB1) and serum amyloid proteins referred as Damage-Associated Molecular patterns (DAMPs) [37]. It is expressed on the surface of various cells, including endothelial, epithelial, and fibroblast mediates multiple signaling pathways such as MAPK kinase and Nuclear factor kappa B (NFĸB), which activate a pro-inflammatory response [38, 39]. Among various TLRs, TLR-2 and 4 are reported to be increased in monocytes of type 1 and type 2 diabetic patients [40, 41] associated with microvascular complications such as retinopathy, nephropathy, and neuropathy [42].
Although various pathways are involved in the pathogenesis of endothelial dysfunction such as activation of the polyol pathway, auto-oxidation of glucose, PKC pathway activation, and formation of AGEs, all these pathways may intersect at several points to increase the complexity of the disease [43]. Among these, increased formations of AGEs (advanced glycation end product) is one of the causes of ECs dysfunction, which has been implicated in the pathogenesis of diabetes-induced vascular complications, as evident by their
The high glucose-induced “oxidative stress” and “endoplasmic reticulum (ER) stress” of the endothelium may play major roles in the initiation and progression of cardiovascular clinical manifestations in diabetes [45]. While diabetes management has largely focused on the control of hyperglycemia, the rising burden of this disease is mainly correlated to its vascular complications [46]. This is reflected by a type II diabetes differs principally from type I diabetes in that it is accompanied by a period of hyperinsulinemia and is characterized by late as opposed to early onset of hyperglycemia. In type I DM, vascular involvement (through endothelial dysfunction) occurs as a result of metabolic insult/hyperglycemia, while in type II DM, endothelial dysfunction plays a more direct role and is aggravated by, rather than caused by, hyperglycemia [6].
One of the best-characterized actions of AGEs on ECs is the induction of ROS [47, 48]. There is considerable evidence to show that AGE induces ROS generation and diminishes the antioxidant defense of the cells [49, 50, 51].
Oxidative stress is induced either by the abundant production of ROS or the failure of the antioxidative machinery mechanism. The main source of ROS is the electrons present in the mitochondrial respiratory chain, which results in the formation of superoxide anion (O2-), hydroxyl radical (OH.) hydrogen peroxide (H2O2). AGEs induce mitochondrial dysfunction through the generation of ROS production.
Mitochondria are complex organelle that undergoes complete fusion and division under physiological or pathological conditions. Mitochondrial fission is defined as the division of a mitochondrion from two or more separate mitochondrial compartments, and this process is essential in the distribution of mtDNA during cell division and helps in the removal of damaged mitochondria through mitophagy. Mitochondrial fusion is merging two or more mitochondria. It is regulated by at least three proteins: optic atrophy 1 (OPA1), mitofusin 1 (MFN1), and mitofusin 2 (MFN2), and mitochondrial fission are controlled by dynamin-related protein 1 (DRP1/DLP1/DNM1), fission 1 (FIS1), and mitochondrial fission factor (MFF) [52, 53]. Studies show that in diabetes, mitochondrial fission is increased [54, 55, 56]. Diabetic animal model (diabetic-STZ model) study demonstrated that HG alters the mitochondrial respiration and alters glomerular bioenergetics, whereas podocytes isolated from those mice showed fragmented mitochondria [57]. Another study in Sprague-Dawley rats (STZ induced) reported an increase in neuronal pyknosis with increased DRP1 expression in neurons when compared with Normal control (NC) group associating that High glucose (HG) aggravated ischemic brain damage and alteration in mitochondrial dynamics [58]. Very importantly, AGEs such as AGE-BSA promoted mitochondrial fission, loss of membrane potential, and apoptosis through the RAGE pathway, whereas blocking the RAGE signaling reduces the events of mitochondrial abnormalities in endothelial and osteoblastic cells [59, 60]. In a rodent model, AGE-BSA disturbs the mitochondrial respiratory chain and induces mitochondrial pore formation with an increase in RAGE expression suggesting the fact that AGE-induced mitochondrial dysfunction plays a major role in diabetic neuropathy [61]. Proteomics study by tandem mass spectrometry (nanoLC-ESI-ETD MS/MS) revealed that renal tubular cells exposed to HG increased phosphorylation and oxidation of mitochondrial proteins when compared with the NG [62]. CML-BSA, another AGE, produces detrimental effects in diabetic db/db mice inducing mitophagy. In this study, CML-BSA treatment in pancreatic β-cells increased RAGE and ROS with a decrease in membrane potential and ATP production with elevated levels of mitochondrial fission (Drp1) and mitophagic proteins (Parkin and PTEN) supporting the factor that increases the concentration of AGEs damage the β-cells and reduces the insulin cells function by making vulnerable to AGEs-induced damages [63].
Under physiological conditions, low concentrations of ROS are needed to maintain cellular proliferation, migration, and survival [64]. However, during the pathological condition, overproduction of ROS induces deleterious effects on the cells and tissues, and to overcome this, the cellular environment has an antioxidative defense system that is capable of scavenging the ROS. The antioxidant defense system includes low-molecular ROS scavengers, antioxidative enzymes, and degrading or repairing proteins [50]. The low-molecular ROS scavengers include glutathione (GSH), vitamin C, and D. Secondly, the antioxidative enzymes superoxide dismutases (SOD) and catalase, which can convert ROS into less reactive ions. The last part of the defense system includes the proteasome and protease system, which will degrade the damaged proteins. The impairments in the antioxidant defense system lead to oxidative stress, which eventually activates various cellular signaling pathways.
Further, AGEs also increase pro-inflammatory response, by augmenting endoplasmic reticulum (ER) stress and amplifying the angiogenic potential of ECs, which has been observed in a myriad of human diseases such as atherosclerosis, acute/chronic inflammatory diseases, vascular complication, and aging [65, 66, 67, 68].
Numerous AGEs-induced vascular diseases display elevated levels of pro-inflammatory cytokine either by directly activating ROS or through engaging with RAGE receptor. AGE-RAGE is a prominent axis that facilitates the activation of NFĸB and MAPK signaling pathways, which subsequently induces the expression of cytokines, chemokines, and adhesion molecules [38, 69]. Elevated levels of AGEs enhanced the release of pro-inflammatory cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor (TNF-α), and interferon-beta (IL-1β). RAGE also binds HMGB1, commonly referred to as damage-associated molecules (DAMPs), and acts as an inflammatory mediator and is released into circulation when there is an injury [70]. Recognition of HMGB1 by RAGE induces the NFĸB activation and its downstream cytokines IL-6, IL-8, and TNF-α. [70, 71] Accumulating evidence shows that DAMPs are reported to mediate the pathogenesis of atherosclerosis and diabetic vascular complications.
Another important feature of inflammatory response is the recruitment and attachment of circulating leukocytes to the endothelium, which is the initial stage in the development of atherosclerosis. Increased adhesion of leukocytes to ECs is facilitated by enhanced expression of chemokines such as monocyte chemoattractant protein (MCP-1) and adhesion molecules such as intercellular adhesion molecules (ICAM), vascular cell adhesion molecules (VCAM), and E-selectins. Studies also demonstrate that direct interaction exists between the ECs adhesion molecules and lymphocyte-function-associated antigen 1 (LFA-1), macrophage-1 antigen (Mac-1), and very late antigen-1 (VLA-1), which are the major counter receptors present on the surface of the leukocytes [39, 72]. Abundant studies show that AGEs elevate the expression of adhesion molecules on the surface of the endothelial cells [73, 74].
Numerous studies provided molecular insights, highlighting the functional link existing between endothelial dysfunction and endoplasmic reticulum (ER) stress [75]. ER is the vital organelle that plays important role in protein folding, lipid biosynthesis, and calcium (Ca2+) regulation. When the ER homeostasis is disturbed either due to increased synthesis of protein, accumulation of misfolded proteins, increased oxidative stress, or alteration in calcium load leads to a condition termed as ER stress. It is closely monitored by the evolutionarily conserved quality control system called unfolded protein response (UPR) [75, 76].
The UPR system is activated by three transmembrane proteins: 1) RNA-dependent protein kinase-like ER eukaryotic initiation factor-2α kinase (PERK), 2) inositol-requiring ER-to-nucleus signaling protein 1 (IRE1), and 3) activating transcription factor 6 (ATF6). These three sensors are inactive form when they are bound with glucose-regulated protein kinase-78 (GRP78) and released upon induction of ER stress. These sensors resolve the ER stress by 1) activating the induction of UPR genes, which enhances the protein folding; 2) attenuation of protein translation, therefore, it reduces the workload of ER; and 3) activating ER-associated degradation (ERAD) pathway activation, which eliminates the unfolded protein through proteasome degradation pathway [75, 77].
During ER stress, activation of the PERK pathway leads to phosphorylation of the eukaryotic translation initiation factor 2 alpha (eIF2α), resulting in the attenuation of protein translation and activating the ATF4 (activating transcription factor-4). ATF4 subsequently induces the activation of pro-apoptotic mediator CHOP (C/EBPα-homologous protein, also known as GADD153) and its downstream target gene, DNA-damage-inducible protein-34 (GADD34). Activation of IRE1 promotes splicing of the endoribonuclease unconventional splicing of an mRNA encoding the transcription factor X-box-binding protein 1 (XBP1s). XBP1s activation further induces the activation of UPR genes, which either increases the ER folding capacity or intersects with AFT4-CHOP to activate the apoptosis. Another UPR pathway is the activation of AFT6, which translocates to the Golgi apparatus. It alleviates misfolded proteins through activation of the ERAD pathway mediated by ATF6-XBP1as shown in Figure 3 [75, 76].
AGEs-induced ER stress in endothelial cells.
Studies reported that under stress conditions, ER show an unusual morphological pattern called ER whorls, which can be used as a biomarker for ER stress [78]. Further compared with the normal cells, DTT treatment (inducer of ER stress) activated the formation of ER whorls, which are seen beneath the plasma membrane, which is in turn imported into the vacuole and proceeds for autophagy [79]. Earlier a study has shown the presence of whorl-like sER in the Leydig cells of STZ-induced mouse model indicating that diabetes can induce morphological changes in ER. Till now there are no studies that have described the effect of AGE on ER morphology. Whereas there are studies that have highlighted the distorted mitochondrial morphology (mitochondrial fission) seen during mitochondrial fission in diabetic animal models [80, 81].
ER and mitochondria are connected through mitochondrial- associated ER membranes (MAMs), which help in the transfer of Ca2+, ATP, and metabolites [82, 83]. As ER stress magnitudes, it increases the releases of Ca2+ from ER to mitochondria, which leads to the opening of mitochondrial membrane pore and releases of cytochrome C, which further intensifies the ROS production. Taken together, it creates a vicious cycle of ER stress and mitochondrial dysfunction, which progresses toward apoptotic signaling [84].
A vast number of studies link ER stress with inflammatory and oxidative signaling pathways, which play a putative role in the development and progression of endothelial dysfunction. Several lines of evidence support the fact that ER stress acts as a potent inflammatory activator because each of the UPR arms activates NFĸB pathway, which in turn releases an array of inflammatory cytokines IL-6, IL-8, and TNF-α [85, 86]. A lot of
Although several studies have identified an array of molecular entities and pathways that activate endothelial dysfunction, the cellular processes underlying endothelial dysfunction are majorly oxidative stress and inflammation. Increasing the intake of fruits and vegetables rich in polyphenols and flavonoids (anti-inflammatory and antioxidant properties) protects the endothelium and reduces the risk of cardiovascular complications [92, 93]. Increasing the endogenous antioxidant may pay way to develop a more effective and safer option. One such endogenous molecule with antioxidative, anti-apoptotic, and anti-inflammatory properties is paraoxonase [94]. Decreased serum paraoxonase (PON) activity is seen in both diabetes, and its complications have been reported, which is attributed to its glycation [95, 96]. The human PON enzyme consists of three family members, paraoxonase (PON1), paraoxonase 2 (PON2), and paraoxonase 3 (PON3). These genes are located on the long arm of chromosome no 7 (7q21-22) with nine exons. Based on the structural homology and from the evolutionary point of view, PON2 is reported to be the oldest member of the family followed by PON3 and PON1 [97]. PON1 is HDL associated and secreted in serum, whereas PON2 and PON3 are located intracellularly mainly in the endoplasmic reticulum, mitochondria, and the nuclear membrane and are ubiquitously expressed in most of the tissues including the liver, kidney, intestine, placenta, etc. [98]. Its role has been explored in many cells including epithelial, endothelial, macrophages, and smooth muscle cells.
PON2 is a ubiquitously expressed antioxidant and anti-inflammatory protein, where its expression and regulation during diabetes- induced complication have not been studied so far. In our recent study, we have established in HUVECs that AGE treatment decreases mRNA, protein, and activity of PON2, whereas overexpression of PON2 alleviates the GA and CML-induced oxidative stress, ER stress, and inflammation through NFκB and ERK1/2 phosphorylation and thereby mitigates pro-inflammatory response [99]. Further silencing of PON2 aggravates GA and CML-induced oxidative stress, ER stress, and pro-inflammatory cytokines expression in HUVEC cells. We found that in diabetic retina PON2 expression was significantly downregulated and HRECs treatment with CML increased mitochondrial fission and aggravates the mitochondrial-dependent apoptosis [100]. Conversely, overexpression of PON2 inhibits the JNK1/2-mediated signaling pathway and rescues the cells from mitochondrial fission and apoptosis as shown in Figure 4 [100].
Possible mechanistic role of PON2 in mitigating AGEs-induced ER stress, pro-inflammation, and mitochondrial dysfunction in endothelial cells.
There are a large number of studies that have established the deleterious effects of AGE on various cellular models. In this chapter, we have discussed in detail how AGEs induce mitochondrial dysfunction, inflammation and endothelial dysfunction through augmenting ER stress. We have also highlighted the association between mitochondrial stress and ER stress. The role of antioxidant PON in inhibiting these deleterious effects has also been discussed.
We thank the Council of Scientific and Industrial Research (CSIR-27 (0310)/14-EMR-11) and Indian Council of Medical Research (ICMR-ID no: 2017-0976/CMB-BMS) for providing the funding and the fellowship.
The authors declare no conflict of interest.
IntechOpen implements a robust policy to minimize and deal with instances of fraud or misconduct. As part of our general commitment to transparency and openness, and in order to maintain high scientific standards, we have a well-defined editorial policy regarding Retractions and Corrections.
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\\n\\n1. RETRACTIONS
\\n\\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\\n\\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\\n\\nPublishing of a Retraction Notice will adhere to the following guidelines:
\\n\\n1.2. REMOVALS AND CANCELLATIONS
\\n\\n2. STATEMENTS OF CONCERN
\\n\\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\\n\\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\\n\\n3. CORRECTIONS
\\n\\nA Correction will be issued by the Academic Editor when:
\\n\\n3.1. ERRATUM
\\n\\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\\n\\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n3.2. CORRIGENDUM
\\n\\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n4. FINAL REMARKS
\\n\\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\\n\\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\\n\\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\\n\\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\\n\\nPolicy last updated: 2017-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
\n\n1. RETRACTIONS
\n\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\n\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\n\nPublishing of a Retraction Notice will adhere to the following guidelines:
\n\n1.2. REMOVALS AND CANCELLATIONS
\n\n2. STATEMENTS OF CONCERN
\n\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\n\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\n\n3. CORRECTIONS
\n\nA Correction will be issued by the Academic Editor when:
\n\n3.1. ERRATUM
\n\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\n\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n3.2. CORRIGENDUM
\n\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n4. FINAL REMARKS
\n\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\n\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\n\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\n\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\n\nPolicy last updated: 2017-09-11
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. 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Motyka",authors:[{id:"101690",title:"Associate Prof.",name:"Maciej",middleName:null,surname:"Motyka",slug:"maciej-motyka",fullName:"Maciej Motyka"},{id:"109232",title:"Prof.",name:"Jan",middleName:null,surname:"Sieniawski",slug:"jan-sieniawski",fullName:"Jan Sieniawski"}]},{id:"46882",doi:"10.5772/58534",title:"Additive Manufacturing of Al Alloys and Aluminium Matrix Composites (AMCs)",slug:"additive-manufacturing-of-al-alloys-and-aluminium-matrix-composites-amcs-",totalDownloads:10131,totalCrossrefCites:52,totalDimensionsCites:117,abstract:null,book:{id:"3844",slug:"light-metal-alloys-applications",title:"Light Metal Alloys Applications",fullTitle:"Light Metal Alloys Applications"},signatures:"Diego Manfredi, Flaviana Calignano, Manickavasagam Krishnan,\nRiccardo Canali, Elisa Paola Ambrosio, Sara Biamino, Daniele Ugues,\nMatteo Pavese and Paolo Fino",authors:[{id:"16648",title:"Dr.",name:"Diego",middleName:null,surname:"Manfredi",slug:"diego-manfredi",fullName:"Diego Manfredi"},{id:"18978",title:"Dr.",name:"Matteo",middleName:null,surname:"Pavese",slug:"matteo-pavese",fullName:"Matteo Pavese"},{id:"19187",title:"Dr.",name:"Sara",middleName:null,surname:"Biamino",slug:"sara-biamino",fullName:"Sara Biamino"},{id:"19188",title:"Dr.",name:"Elisa",middleName:null,surname:"Ambrosio",slug:"elisa-ambrosio",fullName:"Elisa Ambrosio"},{id:"19189",title:"Dr.",name:"Paolo",middleName:null,surname:"Fino",slug:"paolo-fino",fullName:"Paolo Fino"},{id:"170227",title:"Dr.",name:"Flaviana",middleName:null,surname:"Calignano",slug:"flaviana-calignano",fullName:"Flaviana Calignano"},{id:"170228",title:"MSc.",name:"Riccardo",middleName:null,surname:"Canali",slug:"riccardo-canali",fullName:"Riccardo Canali"},{id:"170229",title:"MSc.",name:"Manickavasagam",middleName:null,surname:"Krishnan",slug:"manickavasagam-krishnan",fullName:"Manickavasagam Krishnan"}]}],mostDownloadedChaptersLast30Days:[{id:"70661",title:"Bioremediation Techniques for Polluted Environment: Concept, Advantages, Limitations, and Prospects",slug:"bioremediation-techniques-for-polluted-environment-concept-advantages-limitations-and-prospects",totalDownloads:2672,totalCrossrefCites:10,totalDimensionsCites:30,abstract:"Environmental pollution has been rising in the past few decades due to increased anthropogenic activities. Bioremediation is an attractive and successful cleaning technique to remove toxic waste from polluted environment. Bioremediation is highly involved in degradation, eradication, immobilization, or detoxification diverse chemical wastes and physical hazardous materials from the surrounding through the all-inclusive and action of microorganisms. The main principle is degrading and converting pollutants to less toxic forms. Bioremediation can be carried out ex-situ and in-situ, depending on several factors, which include but not limited to cost, site characteristics, type, and concentration of pollutants. Hence, appropriate bioremediation technique is selected. Additionally, the major methodologies to develop bioremediation are biostimulation, bioaugmentation, bioventing, biopiles, and bioattenuation provided the environmental factors that decide the completion of bioremediation. Bioremediation is the most effective, economical, eco-friendly management tool to manage the polluted environment. All bioremediation techniques have its own advantage and disadvantage because it has its own specific applications.",book:{id:"9343",slug:"trace-metals-in-the-environment-new-approaches-and-recent-advances",title:"Trace Metals in the Environment",fullTitle:"Trace Metals in the Environment - New Approaches and Recent Advances"},signatures:"Indu Sharma",authors:[{id:"301262",title:"Associate Prof.",name:"Indu",middleName:null,surname:"Sharma",slug:"indu-sharma",fullName:"Indu Sharma"}]},{id:"60680",title:"Environmental Contamination by Heavy Metals",slug:"environmental-contamination-by-heavy-metals",totalDownloads:16251,totalCrossrefCites:187,totalDimensionsCites:408,abstract:"The environment and its compartments have been severely polluted by heavy metals. This has compromised the ability of the environment to foster life and render its intrinsic values. Heavy metals are known to be naturally occurring compounds, but anthropogenic activities introduce them in large quantities in different environmental compartments. This leads to the environment’s ability to foster life being reduced as human, animal, and plant health become threatened. This occurs due to bioaccumulation in the food chains as a result of the nondegradable state of the heavy metals. Remediation of heavy metals requires special attention to protect soil quality, air quality, water quality, human health, animal health, and all spheres as a collection. Developed physical and chemical heavy metal remediation technologies are demanding costs which are not feasible, time-consuming, and release additional waste to the environment. This chapter summarises the problems related to heavy metal pollution and various remediation technologies. A case study in South Africa mines were also used.",book:{id:"6534",slug:"heavy-metals",title:"Heavy Metals",fullTitle:"Heavy Metals"},signatures:"Vhahangwele Masindi and Khathutshelo L. Muedi",authors:[{id:"225304",title:"Dr.",name:"Vhahangwele",middleName:null,surname:"Masindi",slug:"vhahangwele-masindi",fullName:"Vhahangwele Masindi"},{id:"241403",title:"M.Sc.",name:"Khathutshelo",middleName:"Lilith",surname:"Muedi",slug:"khathutshelo-muedi",fullName:"Khathutshelo Muedi"}]},{id:"59905",title:"Synthesis of Silver Nanoparticles",slug:"synthesis-of-silver-nanoparticles",totalDownloads:6894,totalCrossrefCites:9,totalDimensionsCites:19,abstract:"Nanoparticles of noble metals, especially the silver nanoparticles, have been widely used in different fields of science. Their unique properties, which can be incorporated into biosensor materials, composite fibers, cosmetic products, antimicrobial applications, conducting materials and electronic components, make them a very important subject to be studied by chemistry, biology, healthcare, electronic and other related branches. These unique properties depend upon size and shape of the silver nanoparticles. Different preparation methods have been reported for the synthesis of the silver nanoparticles, such as electron irradiation, laser ablation, chemical reduction, biological artificial methods, photochemical methods and microwave processing. This chapter aims to inform the synthesis methods of the silver nanoparticles.",book:{id:"6552",slug:"silver-nanoparticles-fabrication-characterization-and-applications",title:"Silver Nanoparticles",fullTitle:"Silver Nanoparticles - Fabrication, Characterization and Applications"},signatures:"Remziye Güzel and Gülbahar Erdal",authors:[{id:"226613",title:"Dr.",name:"Remziye",middleName:null,surname:"Güzel",slug:"remziye-guzel",fullName:"Remziye Güzel"},{id:"240772",title:"MSc.",name:"Gülbahar",middleName:null,surname:"Erdal",slug:"gulbahar-erdal",fullName:"Gülbahar Erdal"}]},{id:"71326",title:"Stability of Metal Complexes",slug:"stability-of-metal-complexes",totalDownloads:2384,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"The stability of coordination complex is an important factor that decides the stability and reactivity of a metal complex. The stability of metal complex is governed by two different aspects such as thermodynamic and kinetic stabilities. The correlation between stability and reactivity of coordination compounds has been described in this chapter. This chapter also enlists the factors influencing the stability of metal complexes such as the nature of metal ions, ligands, bonding between metal ions and ligands, etc. In addition, the methods available for the determination of stability constants are given in detail.",book:{id:"9190",slug:"stability-and-applications-of-coordination-compounds",title:"Stability and Applications of Coordination Compounds",fullTitle:"Stability and Applications of Coordination Compounds"},signatures:"Senthilkumar Muthaiah, Anita Bhatia and Muthukumar Kannan",authors:null},{id:"60518",title:"Synthetic Methods for Titanium Dioxide Nanoparticles: A Review",slug:"synthetic-methods-for-titanium-dioxide-nanoparticles-a-review",totalDownloads:5268,totalCrossrefCites:29,totalDimensionsCites:55,abstract:"Titanium dioxide (TiO2) semiconductor nanoparticles are one kind of important and promising photocatalysts in photocatalysis because of their unique optical and electronic properties. Their properties, which are determined by the preparation method, are very crucial in photocatalysis. In this chapter, an overview was carried out on the different methods that are used or have been used to prepare titanium dioxide nanoparticles. There are various methods that can be used to synthesize TiO2 and the most commonly used methods include sol-gel process, chemical vapor deposition (CVD) and hydrothermal method among others. This review will focus on selected preparation methods of titanium dioxide photocatalyst.",book:{id:"6426",slug:"titanium-dioxide-material-for-a-sustainable-environment",title:"Titanium Dioxide",fullTitle:"Titanium Dioxide - Material for a Sustainable Environment"},signatures:"Pardon Nyamukamba, Omobola Okoh, Henry Mungondori,\nRaymond Taziwa and Simcelile Zinya",authors:[{id:"196100",title:"Dr.",name:"Raymond",middleName:null,surname:"Taziwa",slug:"raymond-taziwa",fullName:"Raymond Taziwa"},{id:"219920",title:"Prof.",name:"Omobola",middleName:null,surname:"Okoh",slug:"omobola-okoh",fullName:"Omobola Okoh"},{id:"226567",title:"Dr.",name:"Pardon",middleName:null,surname:"Nyamukamba",slug:"pardon-nyamukamba",fullName:"Pardon Nyamukamba"},{id:"239758",title:"Mr.",name:"Simcelile",middleName:null,surname:"Zinya",slug:"simcelile-zinya",fullName:"Simcelile Zinya"}]}],onlineFirstChaptersFilter:{topicId:"158",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82118",title:"Surface Hardening of Stainless Steel",slug:"surface-hardening-of-stainless-steel",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.105036",abstract:"The addition of nitrogen to stainless steel improves mechanical and corrosion properties. Nitrogen-bearing stainless steel (HNSS) is a new corrosion-resistant alloy class exhibiting better tribological properties. High-pressure and powder metallurgy techniques were developed for the fabrication of HNSS. Solid-state routes allow nitrogen introduction through thermochemical, implantation, or plasma surface treatments. High-temperature gas nitriding (HTGN), carried out in an N2 atmosphere in the 1000°C range, allows N uptake, obtaining thick, ~0.5–1.0 wt.% N austenitic cases. HTGN is different from conventional nitriding, performed in the 500°C range, where intense CrxNy precipitation occurs, impairing the corrosion resistance. Low-temperature plasma nitriding (LTPN) introduces more N in solution, and colossal supersaturated expanded phases (~45 at.%N) are formed. N supersaturation and compressive stresses increase the hardness of the surface layer to 10–14 GPa. Ferritic, martensitic, duplex, and precipitation-hardened stainless steels can be surface-treated by LTPN, obtaining expanded ferrite and martensite. However, single LTPN stainless steel may prematurely fail when submitted to high loading, as the thin and hard expanded layers collapse due to lack of load-bearing capacity. Duplex-nitriding treatment (HTGN + LTPN) results in a thick nitrogen-rich hardened austenite substrate layer, granting mechanical support and adhesion to the expanded austenite layer.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"André Paulo Tschiptschin and Carlos Eduardo Pinedo"},{id:"81579",title:"Welding Based Additive Manufacturing: Fundamentals",slug:"welding-based-additive-manufacturing-fundamentals",totalDownloads:32,totalDimensionsCites:0,doi:"10.5772/intechopen.104768",abstract:"Additive Manufacturing (AM) has drawn abundant attention over the past decades in the manufacturing and fabrication industries, especially to make part models and prototypes. This chapter introduces a potential welding based AM process called Wire Arc Additive Manufacturing (WAAM) for the fabrication of near-net shaped metal components including stainless steel components. To start with traditional AM processes, various fundamental traditional AM for the fabrication of components have been presented. Wire Arc Additive Manufacturing (WAAM) has been explained with its variants, synonyms, different welding processes to suit WAAM particularly to weld stainless steel metal; primary process selections for working with WAAM, important metals, and alloys that could be used in WAAM have been elaborated. A case study for WAAM fabrication of AISI 316 L stainless steel plate is included to introduce the fabrication of metal components using WAAM. Further, the most common defects which possibly play a vital role in WAAM components fabrication and a few of the future challenges regarding WAAM development are discussed. Fundamental information covered in this chapter could be more beneficial to beginners for the understanding of WAAM process generally including stainless steel component fabrication in a lucid tactic.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Maruthasalam Sowrirajan, Selvaraj Vijayan and Munusamy Arulraj"},{id:"80664",title:"Dependence of Corrosion Resistance of Austenitic Chromium-Nickel Steels on the Magnetic State of Austenite",slug:"dependence-of-corrosion-resistance-of-austenitic-chromium-nickel-steels-on-the-magnetic-state-of-aus",totalDownloads:59,totalDimensionsCites:0,doi:"10.5772/intechopen.102388",abstract:"Corrosive behavior of austenitic chromium-nickel steels from the magnetic state (parameter χ0) of austenite, pre-formed to interact with aggressive media are research. Correlation between the rate K of pitting corrosion and the specific magnetic susceptibility χ0 of austenite was experimentally established. It is experimentally established that the corrosion resistance of austenitic steels AISI304, 08Cr18Ni10, AISI 321, 08Cr18Ni10Тi (containing a low amount of δ-ferrite ∼0.005…0.5%) depends on the magnetic state of austenite: the corrosion rate of steel decreases with increases χ0 austenite. The tendency of change in the corrosion rate of austenitic alloy with a high nickel content 06Crh28NiMoCuTi (not contain δ-ferrite) has the opposite character: with increasing χ0, the corrosion rate of the alloy increases is revealed. For austenitic chromium-nickel steels, the corrosion rates of the individual (austenite (A), δ-ferrite (F), strain-induced α′-martensite (M)) and total (A + F, A + M and A + F + M) phases are determined. It is proposed to predict corrosion according to the specific magnetic susceptibility χ0 of austenite and the amount δ-ferrite.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Gennadii Snizhnoi"},{id:"80199",title:"The Evaluation of the Comparative Corrosion Behaviour of Conventional and Low-Nickel Austenitic Stainless Steel: Hercules™ Alloy",slug:"the-evaluation-of-the-comparative-corrosion-behaviour-of-conventional-and-low-nickel-austenitic-stai",totalDownloads:55,totalDimensionsCites:0,doi:"10.5772/intechopen.102381",abstract:"Austenitic stainless steels require approximately 8% Ni to maintain austenitic microstructure at room temperature for alloys such as 304 stainless steel (304SS). Ni contributes approximately 60% of the total material cost and its price fluctuates, making the cost of austenitic stainless steel unpredictable. The use of low-nickel austenitic stainless steels as a substitute has been considered in order to remedy costs associated with Ni price fluctuations. Alloying elements such as Mn and N have been considered, however they have been found to reduce corrosion resistance. A new alloy namely Hercules™ has been developed with reduced Ni content (1.8–2% Ni). This chapter presents a comparative study of the corrosion behavior of Hercules™ and 304SS in different solutions. The alloys were evaluated using cyclic polarisation technique and immersion tests. The results demonstrated that the corrosion resistance of Hercules™ is comparable to that of 304SS. This presents the alloys as potential industrial substitutes of each other.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Duduzile Nkomo and Nomsombuluko Masia"},{id:"80346",title:"Nitrogen Supersaturation of AISI316 Base Stainless Steels at 673 K and 623 K for Hardening and Microstructure Control",slug:"nitrogen-supersaturation-of-aisi316-base-stainless-steels-at-673-k-and-623-k-for-hardening-and-micro",totalDownloads:59,totalDimensionsCites:1,doi:"10.5772/intechopen.102387",abstract:"The high-density plasma nitriding at 673 K and 623 K was employed to make 10% of nitrogen supersaturation on AISI316 base austenitic stainless steels. The processing parameters and nitrogen-hydrogen gas flow ratio were optimized to increase the yield of N2+ ion and NH-radical for efficient nitriding. The nitrided AISI316 specimens were prepared for multidimensional analysis to describe the fundamental features of low-temperature plasma nitriding. First, macroscopic evaluation revealed that nitrogen supersaturation induced the γ-lattice expansion and the higher nitrogen content than 4% of mass in depth. The mesoscopic analysis describes the holding temperature and initial grain-size effects on the microstructure changes. Plastic straining, grain-size refinement, and nitrogen zone-boundary diffusion processes advance with nitrogen supersaturation to drive the inner nitriding behavior. The microscopic analysis explains the microstructure refinement, the two-phase structuring, and the microstructure modification. Through this multi-dimensional analysis, the essential characteristics of the low-temperature plasma nitriding of 316 austenitic stainless steels were precisely understood to extend the engineering treatise on the bulk nitrogen stainless steels for surface modification and treatment of stainless steels by nitriding. This plasma nitriding was applied to strengthen and harden the AISI316 wire surfaces toward its application on surgery wires.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Tatsuhiko Aizawa, Tomomi Shiratori, Tomoaki Yoshino, Yohei Suzuki and Takafumi Komatsu"},{id:"79904",title:"Corrosion Resistance, Evaluation Methods, and Surface Treatments of Stainless Steels",slug:"corrosion-resistance-evaluation-methods-and-surface-treatments-of-stainless-steels",totalDownloads:106,totalDimensionsCites:1,doi:"10.5772/intechopen.101430",abstract:"Stainless steels are widely recognized and find applications in many engineering industries and companies due to their excellent properties including high resistance to corrosion as a result of their minimum 10.5% chromium content, exceptional strength and durability, temperature resistance, high recyclability, and easy formability. In the present book chapter, the basic concepts of stainless steel including its applications, classifications, and corrosion properties will first be discussed. Thereafter, their corrosion behaviour will then be explained. The various methods by which the corrosion resistance behaviour can be significantly improved including surface treatments such as coatings/electrodepositions, alloying, mechanical treatment, and others will be discussed in detail.",book:{id:"11076",title:"Stainless Steels",coverURL:"https://cdn.intechopen.com/books/images_new/11076.jpg"},signatures:"Temitope Olumide Olugbade"}],onlineFirstChaptersTotal:8},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. 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She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. 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Reasoning in a sustainable way entails, first and foremost, managing the available resources efficiently and strategically, whether they are natural, financial, human or relational. In this way, value is generated by contributing to the growth, improvement and socio-economic development of the communities and of all the players that make up its value chain. In the coming decades, we will need to be able to transition from a society in which economic well-being and health are measured by the growth of production and material consumption, to a society in which we live better while consuming less. In this context, digitization has the potential to disrupt processes, with significant implications for the environment and sustainable development. There are numerous challenges associated with sustainability and digitization, the need to consider new business models capable of extracting value, data ownership and sharing and integration, as well as collaboration across the entire supply chain of a product. In order to generate value, effectively developing a complex system based on sustainability principles is a challenge that requires a deep commitment to both technological factors, such as data and platforms, and human dimensions, such as trust and collaboration. Regular study, research and implementation must be part of the road to sustainable solutions. Consequently, this topic will analyze growth models and techniques aimed at achieving intergenerational equity in terms of economic, social and environmental well-being. It will also cover various subjects, including risk assessment in the context of sustainable economy and a just society.
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