This paper investigates the behavior of a transfer slab system used in medium rise building. For this purpose, two slab-wall full-scale specimens were designed, built, and tested to cyclic loads. The two slab-wall prototypes were exposed to three load stages: (a) vertical load, (b) horizontal load, and (c) vertical and horizontal combined load. The first specimen, SP1, includes a masonry wall situated on top of a squared two-way slab of 4.25 m by side, thickness of 12 cm, on four reinforced concrete girders, while the second specimen, SP2, consists of an identical slab but was constructed with a reinforced concrete wall. Some numerical finite element slab-wall models were built using linear and nonlinear models. The most important results presented herein are the change on lateral stiffness and resistance capacity of the load-bearing wall supported on a slab versus the wall supported on a fixed base and the effects that these walls cause on the slabs. During the experimental test process of horizontal loading, we detected that the stiffness of the two slab-wall systems decreased significantly compared to the one on the fixed base wall, a result supported by the numerical models. The models indicated suitable correlation and were used to conduct a detailed parametric study on various design configurations.