Parameters for evaluating the perovskite single crystal photodetectors.
\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\\n\\n\\n\\n\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8722",leadTitle:null,fullTitle:"E. Coli Infections - Importance of Early Diagnosis and Efficient Treatment",title:"E. Coli Infections",subtitle:"Importance of Early Diagnosis and Efficient Treatment",reviewType:"peer-reviewed",abstract:"Gram-negative Escherichia coli (E. coli) bacteria are the most numerous commensal aerobic germs located in the human colon. Diarrhea caused by E. coli pathogenic strains is a major cause of death in developing countries, especially the sub-Saharan and South Asian areas. Some strains cause diarrhea, and all of them may produce an infectious disease. This book includes ten chapters covering the main aspects of infections related to E. coli, their pathogenic mechanisms, treatments, and resistance to diverse antibiotics.",isbn:"978-1-83962-524-4",printIsbn:"978-1-83962-523-7",pdfIsbn:"978-1-83962-525-1",doi:"10.5772/intechopen.80139",price:119,priceEur:129,priceUsd:155,slug:"e-coli-infections-importance-of-early-diagnosis-and-efficient-treatment",numberOfPages:234,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"f52bd5b65bec376ebb9b8a97f44f4945",bookSignature:"Luis Rodrigo",publishedDate:"September 30th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8722.jpg",numberOfDownloads:8545,numberOfWosCitations:5,numberOfCrossrefCitations:10,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:18,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:33,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 2nd 2019",dateEndSecondStepPublish:"March 6th 2020",dateEndThirdStepPublish:"May 5th 2020",dateEndFourthStepPublish:"July 24th 2020",dateEndFifthStepPublish:"September 22nd 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",biography:"Dr. Luis Rodrigo, MD, is a Professor Emeritus of Medicine, at the University of Oviedo, Spain. He has been Chief of Gastroenterology Service at HUCA Hospital, Oviedo, for more than forty years. He obtained a Ph.D. in 1975 and has developed a long teaching and research career. Dr. Rodrigo has published 716 scientific papers, 435 written in English and the rest in Spanish. He has participated as the main investigator in forty-five clinical trials and has directed forty doctoral theses. He has contributed actively to the formation of around 100 specialists in gastroenterology working in his hospital and other hospitals in Spain and abroad. He has written around thirty-five book chapters and edited twenty-six books in his specialty and related diseases.",institutionString:"University of Oviedo",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"17",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1046",title:"Infectious Diseases",slug:"infectious-diseases"}],chapters:[{id:"71420",title:"Fast Detection of Pathogenic Escherichia coli from Chicken Meats",doi:"10.5772/intechopen.91437",slug:"fast-detection-of-pathogenic-escherichia-coli-from-chicken-meats",totalDownloads:752,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Food is a means to sustain and enjoy life, but it is also a medium for microbial contamination, causing disease and death. Fruits, vegetables, meat, and water are the common sources of contamination. Escherichia coli is one of the most frequent Pathogenic Bacteria responsible for food poisoning and food-related infections. E. coli infection causes severe bloody diarrhea, abdominal cramps, and occasional vomiting. In the present study, electrochemical impedance spectroscopy (EIS), surface plasmon resonance (SPR), and physisorption techniques were evaluated to decrease sample preparation time and to improve the sensitivity and specificity for the detection of low levels of pathogenic Escherichia coli in frozen chicken meat. The electrical and optical properties of the immobilized anti-E. coli antibody were studied. Moreover, the developed biosensor was used for E. coli detection in inoculated frozen chicken meat.",signatures:"Saloua Helali and Adnane Abdelghani",downloadPdfUrl:"/chapter/pdf-download/71420",previewPdfUrl:"/chapter/pdf-preview/71420",authors:[{id:"313149",title:"Dr.",name:"Saloua",surname:"Helali",slug:"saloua-helali",fullName:"Saloua Helali"},{id:"317437",title:"Prof.",name:"Adnane",surname:"Abdelghani",slug:"adnane-abdelghani",fullName:"Adnane Abdelghani"}],corrections:null},{id:"71010",title:"Dietary Intervention to Reduce E. coli Infectious Diarrhea in Young Pigs",doi:"10.5772/intechopen.91219",slug:"dietary-intervention-to-reduce-e-coli-infectious-diarrhea-in-young-pigs",totalDownloads:820,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Postweaning piglets are immediately imposed to remarkable environmental and psychosocial stressors, which adversely affect their intestinal development and health and predispose them to diarrhea. The ratio of postweaning mortality is 6–10% and may rise up to 20% with poor management strategies. Diarrhea per se accounts for 20–30% of cases of mortality in weanling pigs. E. coli postweaning diarrhea is one of the most important causes of postweaning diarrhea in pigs. This diarrhea is responsible for huge economic losses due to high mortality and morbidity, weight loss, and cost of medication. Burgeoning evidence suggested feed-based intervention are one of the promising measures to prevent postweaning diarrhea and to enhance overall health of weaned pigs. Although the exact protective mechanisms may vary and are still not completely understood, a number of feed ingredients or feed additives are marketed to assist in boosting intestinal immunity and regulating gut microbiota. The promising results have been demonstrated in several nutrients (i.e., functional amino acids, organic acids, micro minerals, nondigestible carbohydrates, and antimicrobial peptides), non-nutrients (i.e., phytochemicals and probiotics), and many other feed additives. The efficiencies of each candidate may differ based on their exact modes of action, the basal diet formulation, and the health status of pigs.",signatures:"Peng Ji, Xunde Li and Yanhong Liu",downloadPdfUrl:"/chapter/pdf-download/71010",previewPdfUrl:"/chapter/pdf-preview/71010",authors:[{id:"313005",title:"Dr.",name:"Yanhong",surname:"Liu",slug:"yanhong-liu",fullName:"Yanhong Liu"},{id:"316971",title:"Dr.",name:"Peng",surname:"Ji",slug:"peng-ji",fullName:"Peng Ji"},{id:"316972",title:"Dr.",name:"Xunde",surname:"Li",slug:"xunde-li",fullName:"Xunde Li"}],corrections:null},{id:"72002",title:"Safety Aspect of Recombinant Protein Produced by Escherichia coli: Toxin Evaluation with Strain and Genomic Approach",doi:"10.5772/intechopen.92031",slug:"safety-aspect-of-recombinant-protein-produced-by-escherichia-coli-toxin-evaluation-with-strain-and-g",totalDownloads:565,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Escherichia coli is a Gram-negative bacteria which is well known for its pathogenic properties that can cause serious food poisoning, mostly indicated by diarrhea or other severe symptoms. Despite of its well-known properties due to its ability to produce toxin, most of E. coli strains are harmless and even beneficial especially in recombinant protein production. This bacterium is suitable for protein recombinant host since it has rapid growth, high expression rate, and well-known genome. Various proteins have been produced using E. coli expression systems, with therapeutic protein for medical application being the most notably produced. Apart from that, our group succeeded in producing beta galactosidase from a wild type E. coli strain B130. Furthermore, recombinant human serum albumin was successfully produced using E. coli strains BL21 (DE3). However, studies on E. coli toxin contamination in recombinant protein productions, strains, and genomic comprehension are indispensable, particularly in therapeutic protein. Therefore, this chapter will discuss the safety aspects of recombinant therapeutic proteins in terms of toxin contamination by strain and genomic approaches.",signatures:"Iman Permana Maksum, Ahmad Nabiel, Safri Ishmayana and Ukun M.S. Soedjanaatmadja",downloadPdfUrl:"/chapter/pdf-download/72002",previewPdfUrl:"/chapter/pdf-preview/72002",authors:[{id:"209308",title:"MSc.",name:"Safri",surname:"Ishmayana",slug:"safri-ishmayana",fullName:"Safri Ishmayana"},{id:"317650",title:"Prof.",name:"Ukun",surname:"Soedjanaatmadja",slug:"ukun-soedjanaatmadja",fullName:"Ukun Soedjanaatmadja"},{id:"317654",title:"Prof.",name:"Iman",surname:"P. Maksum",slug:"iman-p.-maksum",fullName:"Iman P. Maksum"},{id:"317663",title:"Mr.",name:"Ahmad",surname:"Nabiel",slug:"ahmad-nabiel",fullName:"Ahmad Nabiel"}],corrections:null},{id:"67766",title:"Aptamers for Infectious Disease Diagnosis",doi:"10.5772/intechopen.86945",slug:"aptamers-for-infectious-disease-diagnosis",totalDownloads:1198,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Aptamers are in vitro-selected, nucleic acids with unique abilities to bind strongly and specifically to their selective targets (ligands) based on their three-dimensional structures. Target binding is generally associated with a change in aptamer structure, which provides a means of linking many output signals to the binding event. Being synthetic, aptamers are less expensive compared to antibodies. Aptamers are also more easily modified chemically or their sequence changed to optimize properties such target specificity, storability and stability. In this chapter we will discuss the potential benefits of applying aptamers to diagnostics with a focus on infectious disease and the unique challenges posed by aptamers for their successful incorporation into reliable aptasensors.",signatures:"Soma Banerjee and Marit Nilsen-Hamilton",downloadPdfUrl:"/chapter/pdf-download/67766",previewPdfUrl:"/chapter/pdf-preview/67766",authors:[{id:"272326",title:"Prof.",name:"Marit",surname:"Nilsen-Hamilton",slug:"marit-nilsen-hamilton",fullName:"Marit Nilsen-Hamilton"},{id:"284468",title:"Dr.",name:"Soma",surname:"Banerjee",slug:"soma-banerjee",fullName:"Soma Banerjee"}],corrections:null},{id:"71365",title:"Systematic Deletion of Type III Secretion System Effectors in Enteropathogenic E. coli Unveils the Role of Non-LEE Effectors in A/E Lesion Formation",doi:"10.5772/intechopen.91677",slug:"systematic-deletion-of-type-iii-secretion-system-effectors-in-enteropathogenic-e-coli-unveils-the-ro",totalDownloads:813,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Enteropathogenic E. coli (EPEC) is a diarrheagenic human pathogen. The hallmark of EPEC infection is the formation of the attaching and effacing (A/E) lesion in the intestinal epithelial cells, characterized by the effacement of brush border microvilli and the intimate bacterial attachment to the enterocyte in actin-rich pedestal-like structures. The locus of enterocyte effacement (LEE) in the EPEC genome encodes a type III protein secretion system (T3SS) that translocates multiple effector proteins into the host cell to subvert cellular functions for the benefit of the pathogen. These effectors are encoded both within and outside the LEE. In vitro cell culture infections have shown that LEE effectors are required for intimate bacterial attachment to the epithelial cells, whereas non-LEE effectors mostly play a role in modulating inflammation and cell apoptosis in the gut epithelium. We constructed a set of EPEC mutant strains harboring deletions in the complete repertoire of genes encoding T3SS effectors. Infection of human intestinal in vitro organ cultures (IVOC) with these mutant strains surprisingly revealed that non-LEE effectors are also needed to induce efficient A/E lesion formation in the intestinal mucosal tissue.",signatures:"Massiel Cepeda-Molero, Stephanie Schüller, Gad Frankel and Luis Ángel Fernández",downloadPdfUrl:"/chapter/pdf-download/71365",previewPdfUrl:"/chapter/pdf-preview/71365",authors:[{id:"313717",title:"Prof.",name:"Luis Ángel",surname:"Fernández",slug:"luis-angel-fernandez",fullName:"Luis Ángel Fernández"},{id:"313718",title:"Dr.",name:"Massiel",surname:"Cepeda-Molero",slug:"massiel-cepeda-molero",fullName:"Massiel Cepeda-Molero"},{id:"313719",title:"Prof.",name:"Stephanie",surname:"Schüller",slug:"stephanie-schuller",fullName:"Stephanie Schüller"},{id:"313720",title:"Prof.",name:"Gad",surname:"Frankel",slug:"gad-frankel",fullName:"Gad Frankel"}],corrections:null},{id:"72979",title:"Management of E. coli\ufeff Sepsis",doi:"10.5772/intechopen.93132",slug:"management-of-e-coli-sepsis",totalDownloads:887,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"E. coli\ufeff is the most common cause of urinary tract infections (UTIs) in humans and is a leading cause of enteric infections and systemic infections. The systemic infections include bacteremia, nosocomial pneumonia, cholecystitis, cholangitis, peritonitis, cellulitis, osteomyelitis, and infectious arthritis. E. coli\ufeff is also the leading cause of neonatal meningitis.",signatures:"Akshay Kumar, Ana Francesca Vommaro Leite, Lais Sanches Maekawa, Roopvir Kaur, Silas Jose Braz Filo, Purnadeo Persaud, Juber Dastagir Shaikh, Asim Kichloo and Nimisha Shiwalkar",downloadPdfUrl:"/chapter/pdf-download/72979",previewPdfUrl:"/chapter/pdf-preview/72979",authors:[{id:"320940",title:"M.D.",name:"Akshay",surname:"Kumar",slug:"akshay-kumar",fullName:"Akshay Kumar"},{id:"321764",title:"Dr.",name:"Nimisha",surname:"Shiwalkar",slug:"nimisha-shiwalkar",fullName:"Nimisha Shiwalkar"},{id:"321765",title:"Dr.",name:"Ana",surname:"Francesca Vommaro Leite",slug:"ana-francesca-vommaro-leite",fullName:"Ana Francesca Vommaro Leite"},{id:"321766",title:"Dr.",name:"Lais",surname:"Sanches Maekewa",slug:"lais-sanches-maekewa",fullName:"Lais Sanches Maekewa"},{id:"321767",title:"Dr.",name:"Silas",surname:"Jose Braz Filho",slug:"silas-jose-braz-filho",fullName:"Silas Jose Braz Filho"},{id:"321768",title:null,name:"Purnadeo",surname:"Persaud",slug:"purnadeo-persaud",fullName:"Purnadeo Persaud"},{id:"323418",title:"Dr.",name:"Roopvir",surname:"Kaur",slug:"roopvir-kaur",fullName:"Roopvir Kaur"},{id:"323419",title:"Dr.",name:"Asim",surname:"Kichloo",slug:"asim-kichloo",fullName:"Asim Kichloo"},{id:"327610",title:"Dr.",name:"Juber Dastagir",surname:"Shaikh",slug:"juber-dastagir-shaikh",fullName:"Juber Dastagir Shaikh"}],corrections:null},{id:"73139",title:"Computational Studies of Drug Repurposing Targeting P-Glycoprotein-Mediated Multidrug-Resistance Phenotypes in Agents of Neglected Tropical Diseases",doi:"10.5772/intechopen.93175",slug:"computational-studies-of-drug-repurposing-targeting-p-glycoprotein-mediated-multidrug-resistance-p-1",totalDownloads:595,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Mammalian ABCB1 P-glycoprotein is an ATP- dependent efflux pump with broad substrate specificity associated with cellular drug resistance. Homologous to this role in mammalian biology, the P-glycoprotein of agents of neglected tropical diseases (NTDs) mediates the emergence of multidrug-resistance phenotypes. The clinical and socioeconomic implications of NTDs are exacerbated by the lack of research interest among Big Pharma for treating such conditions. This work aims to characterise P-gp homologues in certain agents of key NTDs, namely (1) Protozoa: Leishmania major, Trypanosoma cruzi; (2) Helminths: Onchocerca volvulus, Schistosoma mansoni. Based on structural modelling of the organismal P-gp homologues, potential antibiotics targeting these structures were identified based on similarity and repurposing of existing drugs. Docking studies of the Pgp receptor—antibiotic ligand complexes were carried out and the most tenable target-ligand conformations assessed. The interacting residues were identified, and binding pockets studied. The in silico studies yielded measurements of the relative efficacy of the new drugs, which need experimental validation. Our studies could lay the foundation for the development of effective synergistic or new therapies against key neglected tropical diseases. The potential mechanisms of multidrug resistance emergence in E. coli were examined.",signatures:"Nivedita Jaishankar, Sangeetha Muthamilselvan and Ashok Palaniappan",downloadPdfUrl:"/chapter/pdf-download/73139",previewPdfUrl:"/chapter/pdf-preview/73139",authors:[{id:"309489",title:"Dr.",name:"Ashok",surname:"Palaniappan",slug:"ashok-palaniappan",fullName:"Ashok Palaniappan"},{id:"315702",title:"Ms.",name:"Nivedita",surname:"Jaishankar",slug:"nivedita-jaishankar",fullName:"Nivedita Jaishankar"},{id:"315703",title:"Mrs.",name:"Sangeetha",surname:"Muthamilselvan",slug:"sangeetha-muthamilselvan",fullName:"Sangeetha Muthamilselvan"}],corrections:null},{id:"70977",title:"Effects of UV-LED Irradiation on E. coli in Water Disinfection",doi:"10.5772/intechopen.91027",slug:"effects-of-uv-led-irradiation-on-e-coli-in-water-disinfection",totalDownloads:626,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Ultraviolet light-emitting diode (UV-LED) is a newly emerging UV light source with a potential of replacing the conventional chemical methods, mercury UV lamps and xenon lamps in water disinfection applications. In this chapter, we will first give a general description on the status of E. coli disinfection in water by UV-LEDs. Then the main text will concentrate on our experimental studies. We will discuss the effects of single and combined UV-LED irradiation on E. coli in water, including the inactivation efficiency, the recover percentage after the UV-LED irradiation, the optimal wavelength for low energy consumption, differences in pulsed and continuous operations of UV-LEDs, effect of UVA-LED followed by UVC-LED irradiation and vice versa, and finally the effect of TiO2-assisted photocatalytic disinfection.",signatures:"Paul Onkundi Nyangaresi, Baoping Zhang and Liang Shen",downloadPdfUrl:"/chapter/pdf-download/70977",previewPdfUrl:"/chapter/pdf-preview/70977",authors:[{id:"312896",title:"Prof.",name:"Baoping",surname:"Zhang",slug:"baoping-zhang",fullName:"Baoping Zhang"},{id:"316724",title:"Mr.",name:"Paul",surname:"Nyangaresi",slug:"paul-nyangaresi",fullName:"Paul Nyangaresi"},{id:"317091",title:"Dr.",name:"Liang",surname:"Shen",slug:"liang-shen",fullName:"Liang Shen"}],corrections:null},{id:"72615",title:"Antimicrobial Resistance in Escherichia coli",doi:"10.5772/intechopen.93115",slug:"antimicrobial-resistance-in-escherichia-coli",totalDownloads:1654,totalCrossrefCites:6,totalDimensionsCites:8,hasAltmetrics:0,abstract:"In the last decades, antimicrobial resistance has become a global threat to public health systems worldwide. Among those bacteria that pose the greatest threat to human health because of its growing resistance to antibiotics are the members of the Enterobacteriaceae family, particularly Escherichia coli and Klebsiella spp. Among the different antibiotic-resistant mechanisms developed by bacteria, the ones found in Enterobacteriaceae are more diverse than those in other families and include resistance to different antibiotic groups, advantages that partially explain why these microorganisms are among the most common causes of antibiotic-resistant bacterial infections in humans. Due to the continuously increasing number of infections caused by multidrug-resistant E. coli due to its ease of transmission via the fecal-oral route among humans and from environmental sources, the understanding of the epidemiology of these strains and their mechanisms of resistance are key components in the fight against these infections.",signatures:"Mario Galindo-Méndez",downloadPdfUrl:"/chapter/pdf-download/72615",previewPdfUrl:"/chapter/pdf-preview/72615",authors:[{id:"319149",title:"M.Sc.",name:"Mario",surname:"Galindo-Méndez",slug:"mario-galindo-mendez",fullName:"Mario Galindo-Méndez"}],corrections:null},{id:"71853",title:"Antibiotic Resistance among Iraqi Local E. coli Isolates",doi:"10.5772/intechopen.92107",slug:"antibiotic-resistance-among-iraqi-local-e-coli-isolates",totalDownloads:641,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Escherichia coli is a famous Gram-negative bacillary bacterium that belongs to Enterobacteriaceae. It is either micro-biota innocent for human or pathogenic with arrays of diseases. The pathogenic E. coli can be assigned to intestinal (InPEC) or extraintestinal (ExPEC) with disease ranging from watery diarrhea to pulmonary distress. The most prevalent form of InPEC is enteropathogenic E. coli (EPEC), while the most prevalent ExPEC is uropathogenic E. coli (UPEC). The other InPEC includes Shiga toxin–producing (STEC), enteroaggregative (EAEC), enterotoxigenic (ETEC), enteroinvasive (EIEC), diffusely adherent (DAEC) and adherent invasive E. coli (AIEC). ExPEC was implicated in cystitis, pyelonephritis, sepsis, respiratory tract infection, cervicovaginal infection (CVEC), meningitis (NMEC), otitis media, cholecystitis and wound infection. Antibiotic resistance is the challenging in world nowadays. Multidrug-resistant (MDR) Escherichia coli has become challenging with existing antibiotic options. E. coli pathogens have various virulence factors that determine their pathogenesis and antimicrobial resistance mechanisms. The rapid and ongoing spread of antimicrobial-resistant organisms threatens our ability to successfully treat a growing number of infectious diseases. It is well established that antibiotic use is a significant, and modifiable, driver of antibiotic resistance. The most commonly used antibiotic classes for InPEC and ExPEC were third-generation cephalosporin, carbapenem, fluoroquinolone and aminoglycosides. Actually, the most effective prescribed medication is one of the following: cefotaxime, ceftriaxone, ciprofloxacin, amikacin, gentamycin, levofloxacin and imipenem. Generally, according to our review for more than 100 local Iraqi studies among Iraqi provinces, the results revealed the resistance rate from highest to lowest as follows: cefotaxime (76.5%), ceftriaxone (75.9%), gentamycin (41.65%), ciprofloxacin (32.13%), amikacin (17.3%), levofloxacin (15%) and imipenem (5.14%). The resistance mechanisms may include genes encoding antibiotic-modifying enzymes like those of extended-spectrum beta-lactamases gene comprising: blaCTX-M, blaTEM, blaSHV, blaOXA, blaPER, blaVIM, blaIMP, blaNDM and blaAMPc. Efflux pumping includes AcrAB, while resistance to quinolone may be mediated by mutation among qnrA, qnrB, qnrD and qnrS. Resistance to aminoglycosides includes encoding to aminoglycoside-modifying enzymes like aac(6)-Ib, aph(3)-I, aph(3)-IIa, aph(3)-Ib, ant(3)-I, aac(3)-II and aac(3)-IV.",signatures:"Hussein O.M. Al-Dahmoshi, Noor S.K. Al-Khafaji and Mohammed H.O. Al-Allak",downloadPdfUrl:"/chapter/pdf-download/71853",previewPdfUrl:"/chapter/pdf-preview/71853",authors:[{id:"250698",title:"Dr.",name:"Hussein",surname:"O. M. Al-Dahmoshi",slug:"hussein-o.-m.-al-dahmoshi",fullName:"Hussein O. M. Al-Dahmoshi"},{id:"272591",title:"Dr.",name:"Noor S.K",surname:"Al-Khafaji",slug:"noor-s.k-al-khafaji",fullName:"Noor S.K Al-Khafaji"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5388",title:"Human Helminthiasis",subtitle:null,isOpenForSubmission:!1,hash:"6f2002f4cb6e246a51ed8688e076db4d",slug:"human-helminthiasis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/5388.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"932",title:"Acute Pancreatitis",subtitle:null,isOpenForSubmission:!1,hash:"b9e4aebaf0e8a2dd617fe38a5d3b2bff",slug:"acute-pancreatitis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/932.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5752",title:"Celiac Disease and Non-Celiac Gluten Sensitivity",subtitle:null,isOpenForSubmission:!1,hash:"47dfc5b8378b01d915127fa3c1169a90",slug:"celiac-disease-and-non-celiac-gluten-sensitivity",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/5752.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5122",title:"Colorectal Cancer",subtitle:"From Pathogenesis to Treatment",isOpenForSubmission:!1,hash:"5ab8ff026cf9fbd8e3b0097d7f11fe2c",slug:"colorectal-cancer-from-pathogenesis-to-treatment",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/5122.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"983",title:"Pancreatitis",subtitle:"Treatment and Complications",isOpenForSubmission:!1,hash:"062521454256bb4a388ce6fd638dbf1a",slug:"pancreatitis-treatment-and-complications",bookSignature:"Luis Rodrigo Saez",coverURL:"https://cdn.intechopen.com/books/images_new/983.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4478",title:"Acute and Chronic Pancreatitis",subtitle:null,isOpenForSubmission:!1,hash:"4e7a1b71b21315524a24e78819fb7dd3",slug:"acute-and-chronic-pancreatitis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/4478.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6740",title:"Advances in Pancreatic Cancer",subtitle:null,isOpenForSubmission:!1,hash:"500360b038bf8561a30993b0ccb6de91",slug:"advances-in-pancreatic-cancer",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/6740.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6440",title:"Liver Research and Clinical Management",subtitle:null,isOpenForSubmission:!1,hash:"e4bbd66ccead286ab737f23feb053cf8",slug:"liver-research-and-clinical-management",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/6440.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7125",title:"Iron Deficiency Anemia",subtitle:null,isOpenForSubmission:!1,hash:"25d82a6ea6c9d80b195bb40aad06be49",slug:"iron-deficiency-anemia",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/7125.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6061",title:"Ascites",subtitle:"Physiopathology, Treatment, Complications and Prognosis",isOpenForSubmission:!1,hash:"ead9b3e5c36413f9ff2c3129fbc57574",slug:"ascites-physiopathology-treatment-complications-and-prognosis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/6061.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"65367",slug:"corrigendum-to-review-of-liquid-filled-optical-fibre-based-temperature-sensing",title:"Corrigendum to Review of Liquid-Filled Optical Fibre-Based Temperature Sensing",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/65367.pdf",downloadPdfUrl:"/chapter/pdf-download/65367",previewPdfUrl:"/chapter/pdf-preview/65367",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/65367",risUrl:"/chapter/ris/65367",chapter:{id:"63471",slug:"review-of-liquid-filled-optical-fibre-based-temperature-sensing",signatures:"Fintan McGuinness, Gabriel Leen, Elfed Lewis, Gerard Dooly, Daniel Toal\nand Dinesh Babu Duraibabu",dateSubmitted:"May 22nd 2018",dateReviewed:"August 1st 2018",datePrePublished:"November 5th 2018",datePublished:"April 24th 2019",book:{id:"8271",title:"Applications of Optical Fibers for Sensing",subtitle:null,fullTitle:"Applications of Optical Fibers for Sensing",slug:"applications-of-optical-fibers-for-sensing",publishedDate:"April 24th 2019",bookSignature:"Christian Cuadrado-Laborde",coverURL:"https://cdn.intechopen.com/books/images_new/8271.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"220902",title:"Dr.",name:"Christian",middleName:null,surname:"Cuadrado-Laborde",slug:"christian-cuadrado-laborde",fullName:"Christian Cuadrado-Laborde"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"27036",title:"Dr.",name:"Daniel",middleName:null,surname:"Toal",fullName:"Daniel Toal",slug:"daniel-toal",email:"daniel.toal@ul.ie",position:null,institution:null},{id:"85846",title:"Prof.",name:"Elfed",middleName:null,surname:"Lewis",fullName:"Elfed Lewis",slug:"elfed-lewis",email:"Elfed.Lewis@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"259703",title:"Dr.",name:"Dinesh Babu",middleName:null,surname:"Duraibabu",fullName:"Dinesh Babu Duraibabu",slug:"dinesh-babu-duraibabu",email:"dineshbabu.duraibabu@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"269578",title:"Dr.",name:"Gabriel",middleName:null,surname:"Leen",fullName:"Gabriel Leen",slug:"gabriel-leen",email:"Gabriel.Leen@ul.ie",position:null,institution:null},{id:"269579",title:"M.Sc.",name:"Fintan",middleName:null,surname:"McGuinness",fullName:"Fintan McGuinness",slug:"fintan-mcguinness",email:"Fintan.McGuinness@ul.ie",position:null,institution:null},{id:"269580",title:"Dr.",name:"Gerard",middleName:null,surname:"Dooly",fullName:"Gerard Dooly",slug:"gerard-dooly",email:"Gerard.Dooly@ul.ie",position:null,institution:null}]}},chapter:{id:"63471",slug:"review-of-liquid-filled-optical-fibre-based-temperature-sensing",signatures:"Fintan McGuinness, Gabriel Leen, Elfed Lewis, Gerard Dooly, Daniel Toal\nand Dinesh Babu Duraibabu",dateSubmitted:"May 22nd 2018",dateReviewed:"August 1st 2018",datePrePublished:"November 5th 2018",datePublished:"April 24th 2019",book:{id:"8271",title:"Applications of Optical Fibers for Sensing",subtitle:null,fullTitle:"Applications of Optical Fibers for Sensing",slug:"applications-of-optical-fibers-for-sensing",publishedDate:"April 24th 2019",bookSignature:"Christian Cuadrado-Laborde",coverURL:"https://cdn.intechopen.com/books/images_new/8271.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"220902",title:"Dr.",name:"Christian",middleName:null,surname:"Cuadrado-Laborde",slug:"christian-cuadrado-laborde",fullName:"Christian Cuadrado-Laborde"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"27036",title:"Dr.",name:"Daniel",middleName:null,surname:"Toal",fullName:"Daniel Toal",slug:"daniel-toal",email:"daniel.toal@ul.ie",position:null,institution:null},{id:"85846",title:"Prof.",name:"Elfed",middleName:null,surname:"Lewis",fullName:"Elfed Lewis",slug:"elfed-lewis",email:"Elfed.Lewis@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"259703",title:"Dr.",name:"Dinesh Babu",middleName:null,surname:"Duraibabu",fullName:"Dinesh Babu Duraibabu",slug:"dinesh-babu-duraibabu",email:"dineshbabu.duraibabu@ul.ie",position:null,institution:{name:"University of Limerick",institutionURL:null,country:{name:"Ireland"}}},{id:"269578",title:"Dr.",name:"Gabriel",middleName:null,surname:"Leen",fullName:"Gabriel Leen",slug:"gabriel-leen",email:"Gabriel.Leen@ul.ie",position:null,institution:null},{id:"269579",title:"M.Sc.",name:"Fintan",middleName:null,surname:"McGuinness",fullName:"Fintan McGuinness",slug:"fintan-mcguinness",email:"Fintan.McGuinness@ul.ie",position:null,institution:null},{id:"269580",title:"Dr.",name:"Gerard",middleName:null,surname:"Dooly",fullName:"Gerard Dooly",slug:"gerard-dooly",email:"Gerard.Dooly@ul.ie",position:null,institution:null}]},book:{id:"8271",title:"Applications of Optical Fibers for Sensing",subtitle:null,fullTitle:"Applications of Optical Fibers for Sensing",slug:"applications-of-optical-fibers-for-sensing",publishedDate:"April 24th 2019",bookSignature:"Christian Cuadrado-Laborde",coverURL:"https://cdn.intechopen.com/books/images_new/8271.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"220902",title:"Dr.",name:"Christian",middleName:null,surname:"Cuadrado-Laborde",slug:"christian-cuadrado-laborde",fullName:"Christian Cuadrado-Laborde"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11485",leadTitle:null,title:"Wetting and Wettability - Fundamental and Applied Aspects",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tAt first sight, a subject of this book may appear as a rather specialized topic; however, wetting and wettability are fundamental to many important phenomena, including adhesion, penetration of liquids into capillary structures, granulation and agglomeration of fines and powders, interfacial chemical reactions, spreading and retention of liquid sprays on the surface, particle floatation, cleaning, printing and so on. Wetting is also an indispensable part of fluid rheology and fluid dynamics. Therefore, it is an influential theme with countless practical applications including biology, pharmacy, healthcare, agrochemistry, petrochemistry, minerals and metals, ceramics, polymers, coatings, fibers, adhesives, etc. Even though wetting and wettability have been studied since long ago, this remains a very booming research area that reveals new opportunities for discoveries and innovations related to the nanoscale, advanced materials, novel measurement, characterization techniques, and data processing.
\r\n\r\n\tThis book aims to offer a rare opportunity for researchers from various domains to share cutting-edge interdisciplinary knowledge, including both fundamentals and practical applications.
",isbn:"978-1-80356-570-5",printIsbn:"978-1-80356-569-9",pdfIsbn:"978-1-80356-571-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"54b954378e0840f2317b2e94e6c467d6",bookSignature:"Dr. Volodymyr Shatokha",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11485.jpg",keywords:"Methodologies, Work of Adhesion, Surface Free Energy, Interfacial Tension, Contact Angle, Contact Angle Hysteresis, Sliding Angle, Shedding Angle, Wetting Speed, Modelling, Penetration, Spreading",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 11th 2022",dateEndSecondStepPublish:"May 12th 2022",dateEndThirdStepPublish:"July 11th 2022",dateEndFourthStepPublish:"September 29th 2022",dateEndFifthStepPublish:"November 28th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"A renowned researcher in ironmaking and steelmaking served 20 years as Vice-Rector for Research and Education of the National Metallurgical Academy of Ukraine, Laureate of the State Prize of Ukraine in Science and Technology, and holder of patents ‘’Production of nano-sized ferrite comprising oxidizing a molten slag’’ and ‘’Production of nano-sized ferrite’’.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"111000",title:"Dr.",name:"Volodymyr",middleName:null,surname:"Shatokha",slug:"volodymyr-shatokha",fullName:"Volodymyr Shatokha",profilePictureURL:"https://mts.intechopen.com/storage/users/111000/images/system/111000.jpg",biography:"Volodymyr Shatokha graduated in 1982 as a Ferrous Metallurgy engineer. In 1985, he received a Ph.D. degree from the Dnipropetrovsk Metallurgical Institute (known since 1999 as the National Metallurgical Academy of Ukraine and since 2021 as the Ukrainian State University of Science and Technology). In 1998, he received the title of professor with the Ironmaking Chair. During 1999–2002, he was the dean of the Metallurgical Faculty. During 2002-2021, he was the vice-rector for Research and Education. Since 2022 he is a professor of the Ironmaking & Steelmaking Department. His research deals mainly with the properties of iron ore materials, physicochemical processes of ironmaking, recycling methods, sustainability analysis, etc. He is the author of over 180 research papers, 7 books, and 7 patents. He is the honorary professor at the Inner Mongolia University of Science and Technology, China, and a visiting professor at the University of Tokyo (2013). He is a laureate of the State Prize of Ukraine in Science and Technology (2010) and a fellow of the Erasmus+ Jean Monnet Programme for the EU climate and energy policy studies (since 2015).",institutionString:"Ukrainian State University of Science and Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"3",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"14",title:"Materials Science",slug:"materials-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453624",firstName:"Martina",lastName:"Scerbe",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/453624/images/20399_n.jpg",email:"martina.s@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"2132",title:"Sintering",subtitle:"Methods and Products",isOpenForSubmission:!1,hash:"a4374d54a1172051ff65e9f3aebee8f3",slug:"sintering-methods-and-products",bookSignature:"Volodymyr Shatokha",coverURL:"https://cdn.intechopen.com/books/images_new/2132.jpg",editedByType:"Edited by",editors:[{id:"111000",title:"Dr.",name:"Volodymyr",surname:"Shatokha",slug:"volodymyr-shatokha",fullName:"Volodymyr Shatokha"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6335",title:"Iron Ores and Iron Oxide Materials",subtitle:null,isOpenForSubmission:!1,hash:"26195f784577133f2972d538cef6f8c9",slug:"iron-ores-and-iron-oxide-materials",bookSignature:"Volodymyr Shatokha",coverURL:"https://cdn.intechopen.com/books/images_new/6335.jpg",editedByType:"Edited by",editors:[{id:"111000",title:"Dr.",name:"Volodymyr",surname:"Shatokha",slug:"volodymyr-shatokha",fullName:"Volodymyr Shatokha"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9991",title:"Iron Ores",subtitle:null,isOpenForSubmission:!1,hash:"f1b2c288312233e1be62cd01c7e74fec",slug:"iron-ores",bookSignature:"Volodymyr Shatokha",coverURL:"https://cdn.intechopen.com/books/images_new/9991.jpg",editedByType:"Edited by",editors:[{id:"111000",title:"Dr.",name:"Volodymyr",surname:"Shatokha",slug:"volodymyr-shatokha",fullName:"Volodymyr Shatokha"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6320",title:"Advances in Glass Science and Technology",subtitle:null,isOpenForSubmission:!1,hash:"6d0a32a0cf9806bccd04101a8b6e1b95",slug:"advances-in-glass-science-and-technology",bookSignature:"Vincenzo M. Sglavo",coverURL:"https://cdn.intechopen.com/books/images_new/6320.jpg",editedByType:"Edited by",editors:[{id:"17426",title:"Prof.",name:"Vincenzo Maria",surname:"Sglavo",slug:"vincenzo-maria-sglavo",fullName:"Vincenzo Maria Sglavo"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6802",title:"Graphene Oxide",subtitle:"Applications and Opportunities",isOpenForSubmission:!1,hash:"075b313e11be74c55a1f66be5dd56b40",slug:"graphene-oxide-applications-and-opportunities",bookSignature:"Ganesh Kamble",coverURL:"https://cdn.intechopen.com/books/images_new/6802.jpg",editedByType:"Edited by",editors:[{id:"236420",title:"Dr.",name:"Ganesh",surname:"Kamble",slug:"ganesh-kamble",fullName:"Ganesh Kamble"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6517",title:"Emerging Solar Energy Materials",subtitle:null,isOpenForSubmission:!1,hash:"186936bb201bb186fb04b095aa39d9b8",slug:"emerging-solar-energy-materials",bookSignature:"Sadia Ameen, M. Shaheer Akhtar and Hyung-Shik Shin",coverURL:"https://cdn.intechopen.com/books/images_new/6517.jpg",editedByType:"Edited by",editors:[{id:"52613",title:"Dr.",name:"Sadia",surname:"Ameen",slug:"sadia-ameen",fullName:"Sadia Ameen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6188",title:"Solidification",subtitle:null,isOpenForSubmission:!1,hash:"0405c42586170a1def7a4b011c5f2b60",slug:"solidification",bookSignature:"Alicia Esther Ares",coverURL:"https://cdn.intechopen.com/books/images_new/6188.jpg",editedByType:"Edited by",editors:[{id:"91095",title:"Dr.",name:"Alicia Esther",surname:"Ares",slug:"alicia-esther-ares",fullName:"Alicia Esther Ares"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6656",title:"Phase Change Materials and Their Applications",subtitle:null,isOpenForSubmission:!1,hash:"9b257f8386280bdde4633d36124787f2",slug:"phase-change-materials-and-their-applications",bookSignature:"Mohsen Mhadhbi",coverURL:"https://cdn.intechopen.com/books/images_new/6656.jpg",editedByType:"Edited by",editors:[{id:"228366",title:"Dr.",name:"Mohsen",surname:"Mhadhbi",slug:"mohsen-mhadhbi",fullName:"Mohsen Mhadhbi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6805",title:"Electrical and Electronic Properties of Materials",subtitle:null,isOpenForSubmission:!1,hash:"f6b6930e7ae9d0704f68b5c180526309",slug:"electrical-and-electronic-properties-of-materials",bookSignature:"Md. Kawsar Alam",coverURL:"https://cdn.intechopen.com/books/images_new/6805.jpg",editedByType:"Edited by",editors:[{id:"199691",title:"Dr.",name:"Md. Kawsar",surname:"Alam",slug:"md.-kawsar-alam",fullName:"Md. Kawsar Alam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6851",title:"New Uses of Micro and Nanomaterials",subtitle:null,isOpenForSubmission:!1,hash:"49e0ab8961c52c159da40dd3ec039be0",slug:"new-uses-of-micro-and-nanomaterials",bookSignature:"Marcelo Rubén Pagnola, Jairo Useche Vivero and Andres Guillermo Marrugo",coverURL:"https://cdn.intechopen.com/books/images_new/6851.jpg",editedByType:"Edited by",editors:[{id:"112233",title:"Dr.Ing.",name:"Marcelo Rubén",surname:"Pagnola",slug:"marcelo-ruben-pagnola",fullName:"Marcelo Rubén Pagnola"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"53962",title:"Radiotherapy in Lung Cancer",doi:"10.5772/67204",slug:"radiotherapy-in-lung-cancer",body:'\nAccording to the World Cancer Report 2014, lung cancer remains the top five most common cancers among both men and women worldwide. And it is also the leading cause of cancer deaths. Majority (around 85%) are nonsmall cell lung carcinomas [1, 2]. Incidence of adenocarcinoma had been rising and now became the most common histological subtypes in both men and women. About one‐third of them are presented with early stage localized disease (stage I–II), another one‐third with locally advanced disease (stage III), and remaining one‐third with metastatic disease (stage IV) at diagnosis [3, 4].
Lungs are a paired structure that is separated into left and right by the mediastinum, which contains the tracheal, heart, esophagus, and lymph nodes. The left lung is divided into upper and lower lobe by oblique fissure, while the right lung is divided into three lobes (upper, middle, and lower) by oblique and horizontal fissures.
\nLung cancers can arise from mucosa of the tracheobronchial tree or the alveolar lining cells of peripheral lung parenchyma. Tumor can spread locally within lung parenchyma or invading surrounding structures including mediastinum, major vessels, or chest wall (Figure 1). They can also spread along major airways causing obstruction, distal collapse, or atelectasis (Figure 2).
\nTumor invasion to chest wall.
Tumor over left main bronchus causing collapse of left upper lobe (red arrow).
There is rich lymphatic within the respiratory system that accounts for the high rate of nodal metastasis. The lymph node map proposed by the International Association for the Study of Lung Cancer (ISALC) in 2009 divides the lymph nodes into 14 stations and sever zones [5]. It is adopted by the latest seventh edition of AJCC and UICC Manual for N staging, with involvement of ipsilateral hila node as N1, ipsilateral mediastinal nodes as N2, and contralateral mediastinal or supraclavicular nodes as N3. Lymph nodes drainage depends on the location of tumors, with those in left upper lobe drain predominantly into subaortic node and those in right upper lobe drain predominantly into right upper paratracheal node. Middle and lower lobe tumors drain more commonly into subcarinal and lower paratracheal nodes. However, skip metastasis to mediastinal nodes bypassing hilar nodes occur in around 10–25% tumors [6]. Lymph nodes with short axis diameter ≥10 mm is considered suspicious of nodal metastasis (Figure 3).
\nEnlarged mediastinal lymph node over (a) right upper paratracheal node (station 2R) and (b) subaortic node (station 5).
All patients with suspected lung cancer should have computer tomography (CT) of thorax with intravenous contrast for proper staging. Histological proof from primary tumors can be obtained by bronchoscopy if centrally located or by image‐guided approach if peripherally located. For those patients planned for radical treatment, positron emission tomography (PET) scan is recommended to exclude any distant metastasis. Unanticipated metastasis may be detected in up to 10–20% cases. It is also more useful than CT in differentiating collapse or atelectasis from primary tumors (Figure 4). Any suspicious lymph nodes based on enlargement on CT or uptake in PET should be confirmed by needle technique (e.g., endoscopic ultrasound) or mediastinoscopy.
\nUse of PET in differentiating primary tumor with intense uptake (red arrow) from surrounding collapse or atetactasis (white arrow).
Radical surgery remained the preferred treatment in early stage I–II lung cancer with 5‐year overall survival rate of around 60–80%. Radical radiotherapy can be an alternative to patients who are medically unfit for surgery due to medical comorbidities or who declined surgery. Currently, there are no phase III trials to directly compare the outcomes after surgery with radiotherapy. Retrospective and historical databases showed that the long‐term survival after conventional radiotherapy may be half (or even less) than that after surgery, with 5‐year survival of around 20–30% in most series. But this indirect comparison is difficult due to the different population groups with more elderly, comorbidities, or poor lung function in those nonsurgical series. For elderly patients, hypofractionated scheme using 55 Gray (Gy) in 20 daily fractions is as effective as conventional radiotherapy in 2Gy per fraction.
\nStereotactic body radiotherapy (SBRT) is now a newly emerging treatment option that allows delivery of a much higher radiation dose to a precise area than conventional radiotherapy. The reported local control rate in early stage lung cancer can be up to 80–90% in 2 years and is well tolerated. Therefore, it becomes the preferred radiotherapy modality for stage I lung cancer patients who are not fit for surgery. But extra care should be given when treating tumors that are centrally located around the major airways due to the potential higher complications with the hypofractionated regime.
This stage of disease was considered locally advanced either due to extensive primary tumor extension to extrathoracic structures nearby (T3 or T4) or mediastinal lymph nodes involvement (N2 or N3). It is a heterogeneous population that requires multimodality treatments. The reported 5‐year survival was around 10–30%. A multidisciplinary discussion involving cardiothoracic surgeons, radiologists, and oncologists is needed to individualize and optimize the treatment plan for each patient. Patients with good performance status 0–1, no significant weight loss of >10% in the preceding 3 months and good pulmonary function (forced expiratory volume in 1 second FEV1 > 1.0 L) are candidates for radical combined modality treatment.
\nFor potentially operable N2 disease, induction treatment with either chemotherapy alone or chemoirradiation is recommended over surgery alone. There is no solid evidence to support the superiority of either approach. Addition of preoperative radiotherapy may have the potential effect in downstaging the tumor and achieving a higher pathological complete remission rate of mediastinal disease. Special precaution should be given with its use in candidates before a planned pneumonectomy due to the higher perioperative mortalities. When preoperative radiotherapy is considered, a dose higher than 45–54 Gy in 1.8–2 Gy per fraction had not been shown to give addition survival benefit.
\nFor infiltrative N2 or N3 (contralateral mediastinum) disease, risk of systemic micrometastases is high. Definitive chemoirradation is the commonly used approach. Addition of chemotherapy to radical radiotherapy led to a survival benefit of 5–10% at 5 years. Concomitant use of chemotherapy had a further improvement in survival by 4.5% at 5 years when compared with sequential approach, but with the expense of higher toxicities (mainly esophagitis and/or pneumonitis). Platinum‐based doublet chemotherapy is the preferred regime and usually 2–4 cycles are given [7, 8]. Thus, concurrent chemoirradiation is the preferred strategy for fit patients, while sequential approach can be used for less fit patients with disease still within a treatable radical radiotherapy volume. A dose higher than 70 Gy in conventional fractionation is not recommended due to the associated higher toxicities but no added survival benefit. A continuous, hyperfractionated, accelerated radiotherapy (CHART) using 54 Gy in 36 fractions of 1.5 Gy three times per day can be considered for selected patients opting for radiotherapy alone. It had around 20% relative risk reduction in 2‐year local progression rate and survival compared with conventional radiotherapy, but implementation can be challenging.
\nFor patients with performance status 3–4, significant comorbidities and poor lung function that preclude a radical treatment approach, palliative radiotherapy may be considered for local symptoms control.
Early radiotherapy to thorax in patients with incurable disease but no or minimal symptoms had not been shown to improve symptom control, survival, or quality of life. Hence, palliative thoracic radiotherapy can be deferred till symptoms emerged. Common indications are cough, hemoptysis, chest pain, and airway obstruction [9]. The optimal radiotherapy dose and fractionation schedule remained unclear. While there is no significant difference in symptom control with different dose schedules, a small survival improvement may be seen with higher dose radiotherapy.
\nFor malignancy‐related superior vena cava obstruction, external beam radiotherapy is effective in 60% patients with nonsmall cell lung cancers and 80% patients with small cell lung cancers [10]. Chemotherapy is another treatment option for patients with chemosensitive tumors like lymphoma, germ cell tumors, or small cell tumors. Intravascular stent insertion may be considered for patients that require rapid relief of symptoms, those who fail to response or relapse after radiotherapy.
\nPalliative radiotherapy can also be given to distant metastatic sites (e.g., bone, skin). Single fraction radiotherapy is as effective as longer course radiotherapy in pain and local symptom control.
Adjuvant postoperative radiotherapy (PORT) helps to improve local control in patients with high risk of local recurrence after surgery, including those with pathological N2 disease and incomplete resection either microscopically or macroscopically. A careful evaluation of general conditions and remaining lung reserves is required before the start of treatment. It is not routinely given to early stage I–II disease with clear resection due to the potential detrimental effect on overall survival from previous meta‐analyses that include trials using large radiation fields and nonconformal radiation techniques. However, its role with the use of modern radiotherapy machine and conformal radiotherapy are unclear and further research is warranted.
Patient will lie supine with arms above head holding a T‐bar device and elbow supported laterally (Figure 5) to facilitate different beam angle entry for treatment. Knee support can be given to allow a more comfortable position when needed. Vacuum bag can be added to reduce movement if treatment time is long. For palliative setting using AP beams only, patients usually lie supine with arms beside body.
\nImmobilization for thoracic radiotherapy with T‐bar and elbow support.
For treatment with radical intent, computer‐tomography from cricoid to lower border of L1 is needed to cover the whole lung for calculation of lung dose. Slice thickness of 3–5 mm allows better quality of images for target volume delineation. Intravenous contrast is not essential but is preferred when mediastinal disease is present so as to allow better visualization of the extent.
\nFor treatment of palliative intent, radiation field border can be defined by simple X‐ray simulation. Radio‐opaque markers (e.g. lead wire) can be used to mark any clinically palpable diseases that are going to be included for radiotherapy (e.g., chest wall mass, supraclavicular lymph nodes).
\nTo aid set‐up, tattoos will be marked on beam center or isocenter, together with lateral reference points over left and right side of the body.
Patient should be immobilized in a comfortable position to avoid movement during the longer treatment length of each fraction. In this way, a supine position with arms above head immobilized by wing board and vacuum bag is commonly used (Figure 6).
\nImmobilization with wing board and vacuum bag for SBRT of lung cancer.
Fluoroscopy can be used to visualize tumor motion. But it only allows tumor motion assessment in two dimensions and can be difficult if with indistinct border of tumors. Noncontrast four‐dimensional CT (4D CT) is a better option, which is a fast scanner that acquires multiset of CT images over consecutive phases of breathing cycle. Information about patients’ breathing cycle and amplitude can be recorded by infrared reflecting marker and a coupled camera (Figure 7). And different CT images set will be sorted according to different phases in the respiratory cycle (Figure 8).
\nInfrared system including reflecting marker on patient\'s xiphsternum and coupled camera for tracking breathing cycle.
Sorting of 4D CT images by different phases in respiratory cycle.
Additional methods should be considered to reduce the tumor movement when it is ≥1cm, including abdominal compression, breath‐hold, respiratory gating, or active breathing control. Both breath‐hold and active breathing control require sufficient lung reserve to allow holding each breath for at least 20 seconds, which may be difficult for most of patients with lung cancers. Respiratory gating allows free breathing and beam on in certain phase of respiration. But it requires the use of fiducial markers to track internal tumor motion and is time consuming. Abdominal compression is the most commonly used method but reproducibility can be difficult (Figure 9). So the best method to be used depends on the patient\'s condition, tolerance, and corporation.
\nAbdominal compressor on patient\'s belly to reduce respiratory motion.
Any clinical information and findings from bronchoscopy and mediastinoscopy should be gathered and correlated with diagnostic images. For postoperative cases, surgical records and pathology reports should be reviewed. And in case with doubt, discussions with surgeons and pathologists are encouraged to identify sites at risk of recurrence. Clips that are placed intraoperatively at sites with incomplete resection are useful for target identification.
\nAn appropriate window setting should be used to delineate different targets on planning CT. Extent of primary lung tumor and mediastinal disease is best visualized by lung setting (window width 1600 and window level -600) and soft tissue setting (window width 400 and window level 20), respectively (Figure 10). Diagnostic imaging (e.g., CT or PET) should be coregistered with the planning of CT for contouring. PET images can help delineate area of collapse and atelectasis from tumors, but care should be taken when matching the images due to poor spatial resolution and breathing motion artifact.
\nSoft tissue window setting (a) in planning CT to define the mediastinal lymph node (red arrow), which cannot be easily seen in lung window (b).
Gross tumor volume of primary tumor (GTV‐P) is best contoured on lung window setting to include any visible tumor within lung parenchyma and the speculated border. Any local invasion to surrounding structures (e.g., chest wall, vertebra) should be included as well based on soft tissue window setting. Areas of collapse or atelectasis were excluded but can be difficult to differentiate. Input from radiologists and PET may be useful. Elective nodal irradiation is not recommended as isolated nodal recurrences are rare. So GTV of lymph node (GTV‐N) will only include any pathologically confirmed lymph nodes (fine needle cytology or core biopsy) and any suspicious lymph nodes based on imaging characteristics (including short axis diameter ≥1 cm, necrotic center or PET uptake). If chemotherapy had been used before radiotherapy, all initial sites of tumor involvement should be contoured unless it exceeds a tolerable radiotherapy portal.
\nAn isotropic margin is then added to GTV‐P to cover microscopic tumor spread to form the clinical target volume (CTV‐P). Usually, a 6 mm margin for adenocarcinoma and an 8 mm margin for squamous cell carcinoma are used as it had been shown to cover around 95% of microscopic tumor extension on pathological specimens [11]. Subsequent CTV‐P is edited according to the presence of natural barriers (e.g., great vessels, bone). For GTV‐N, usually no additional margin is needed for CTV.
\nA margin from CTV to PTV (planning target volume) depends on tumor motion and daily set‐up errors (Figure 11). Tumor motion can be quite variable from zero in cases using implanted fiducial markers in image‐guided radiotherapy to certain centimeters in cases without any breathing motion control. Set‐up errors are regularly measured in each department and usually within 5 mm in all directions. In common practice with free breathing treatment, a 1 cm isotropic margin is usually given to form the PTV. But a larger superior‐inferior margin of 1.5 cm may be used for tumors with greater movement as long as the lung dose is within the tolerance limit.
\nTarget volume delineation: primary lung tumor (T) is contoured on lung window as gross tumor volume (GTV; red line); an additional 6 mm is added to form clinical target volume (CTV; blue line) to cover microscopic spread; further 1 cm margin is added to form the planning target volume (PTV; green line) to account for tumor motion and set‐up error.
For palliative radiotherapy using AP beams, information about tumor extent from diagnostic imaging can be superimposed on those visible on simulator to form the GTV. And a further 1.5 cm margin from GTV can be used to define the radiotherapy field border.
Internal target volume (ITV) takes into account both GTV and internal tumor motion. It can be generated from the 4D CT using the maximum intensity projection (MIP) scan, maximum inspiratory, and expiratory scans, or all 10 phases of respiratory cycles (Figure 12). No CTV is needed. The usual CTV to PTV margin is 3–5mm, but it depends on methods of immobilization, tumor motion assessments, and treatment verification.
\nTarget delineation on 4D CT: tumor is contoured on MIP images to form the internal target volume (ITV; red line); addition 5 mm margin was used to generate the planning target volume (PTV; green line).
Organs at risk including heart, esophagus, and spinal cord will be contoured using soft tissue window. The heart includes the whole structure within pericardial sac starting from the pulmonary artery to the apex. All layers of esophagus will be included and contoured from the cricoid cartilage to the esophagogastric junction. Spinal cord will be contoured at least 10 cm above and below PTV. For tumors over upper chest, the ipsilateral brachial plexus should also be contoured. Both left and right lungs are also contoured and then used to form a new structure called lung minus PTV after subtraction.
\nFor SBRT, the tracheal and proximal bronchial tree should be contoured as well. Trachea will start from the level of cricoid cartilage to 2 cm above the carina, where it then continuous with the proximal bronchial tree (PBT, Figure 13) including the distal 2 cm trachea, main carina, bilateral main bronchi, bilateral upper lobe bronchi, lingular bronchus, intermedia bronchus, right middle lobe bronchus, and bilateral lower lobe bronchi. A 2 cm margin applied around the PTB will then be used to form a PRV (planning organ at risk volume).
\nDefinition of proximal bronchial tree.
For radical treatment, three‐field conformal radiotherapy is most commonly used. The choices of beam numbers and beam angles depend on the location of the tumor and proximity to OARs. For early stage I–II tumors with lateralized target volume, a lateral, anterior, and posterior oblique beams are usually chosen to reduce irradiate contralateral lung (Figure 14).
\nBeam arrangement in a three‐field conformal radiotherapy for early stage lung cancer (red line = GTV; green line = PTV).
For more advanced stage disease with tumor involvement to mediastinum or across midline, the above three‐field technique using ipsilateral beams only may not give good dose coverage to target, and addition of contralateral beam will increase total lung dose. In such case, two phases treatment should be considered. First phase will treat the mediastinum using AP beams shaped by multileaf collimator (MLC), while the second phase will use conformal technique to give adequate coverage to all the target volume. With this approach, total lung dose can be reduced but OARs near midline (e.g., esophagus, spinal cord) will receive higher dose.
\nFor palliative radiotherapy, anterior and posterior fields modified by MLC are usually used with dose prescribed to midplane. Energy of photon beam used will depend on separation at the center of the field.
\nRadiotherapy plans should be carefully evaluated using dose‐volume histogram (DVH). Optimal plan should aim at 95% PTV receiving at least 100% of the prescribed dose and 99% PTV receiving a minimum of 90% of the prescribed dose. For OARs, commonly used dose constrains for lung minus PTV is V20 (volume receiving >20 Gy) below 35%, preferably below 30%. However, a tighter constrain to reduce the risk of radiation pneumonitis should be considered when there is presence of other risk factors including preexiting lung disease and concurrent use of chemotherapy. Another frequently used limit is the mean lung dose below 20 Gy. The dose constrains for other OARs are maximum dose to spinal cord less than 45 Gy and heart V20 less than 40 Gy. Care should be given to avoid irradiation of more than 10 cm length of the esophagus due to higher long‐term risk of stricture.
\nFor SBRT, either intensity‐modulated radiotherapy using 6–8 fields (IMRT) or rapidarc therapy is recommended to deliver a high and conformal dose to a precise area (Figure 15). Dose to skin should be minimized to avoid cutaneous and subcutaneous toxicities. Recommendations to other OARs can be made reference to that published by ROSEL study and RTOG 0813 study.
\nBeam arrangement and dose color wash from SBRT for lung cancer using IMRT technique.
\n
For peripherally located tumor: 54 Gy in three fractions or 60 Gy in five fractions, alternate day treatment over 1–2 weeks (more conservative schedule is recommended if PTV is in contact with chest wall to avoid rib toxicities).
For centrally located tumor (defined as GTV within 2 cm from proximal bronchial tree): 50 Gy in 10 fractions, alternate day treatment over 2 weeks.
\n
60–70 Gy in 30–35 daily fractions over 6–6.5 weeks.
Consider hypofractionated regime of 55 Gy in 20 daily fractions over 4 weeks if elderly.
\n
For preoperative treatment (with or without chemotherapy): 45–54 Gy in 1.8–2 Gy per fraction over 5–6 weeks.
For definitive treatment with concurrent chemotherapy: 60–66 Gy in 30–33 daily fractions over 6–6.5 weeks (consider treat up to 70 Gy in 35 daily fractions over 7 weeks if no chemotherapy given and within lung dose tolerance).
\n
For complete resection: 50 Gy in 25 daily fractions over 5 weeks.
For incomplete resection: 60 Gy in 30 daily fractions over 6 weeks (consider boost up to 66 Gy in 33 daily fractions if gross residual disease).
\n
For PS 0–1 and life expectancy >6 months: 30 Gy in 10 daily fractions over 2 weeks (consider 39 Gy in 13 daily fractions over 2.5 weeks if spinal cord not within treated volume).
For PS ≥ 2: 20 Gy in five daily fractions over 1 week or 10 Gy single fraction.
Portal images by electronic portal imaging device on treatment machines are taken on first 3 days on treatment and then weekly afterwards. These are compared and registered with digitally reconstructed radiography (DRR) from CT simulations to allow offline corrections. For SBRT, cone beam CT by onboard imaging on treatment machine is done daily to allow online correction before delivery of each fraction of treatment.
\nDuring treatment period, patients should be reviewed at least once by radiation oncologists for assessment of any acute radiation side effects. Mild chest symptoms like cough or dyspnea are common but concomitant chest infection should be excluded if symptoms worsened. Dysphagia can occur due to esophagitis which usually start at around third week. Adequate analgesics and diet advice should be given to minimize severity and the impact on nutrition or weight loss.
After radical treatment, CT of thorax and upper abdomen should be done 3 monthly in the first 2 years, then half yearly till 5 years, and then annually to evaluate disease status. Long‐term toxicities especially on lung function and esophageal stricture should be regularly reviewed and managed accordingly.
Perovskite-structured materials have received increasing attention, since being discovered in the 1830s, because of their rich physical properties [1]. As shown in \nFigure 1a\n [2], the general chemical formula for such compounds is ABX3, in which A and B are different cations, and X is an anion that bonds to both the A and B cations. Owing to the flexibility of bond angles inherent in the perovskite structure, there are many different distortions that can occur from the ideal structure. Importantly, A can be organic cations, like methylammonium (MA+) or formamidinium (FA+) [4, 5, 6, 7, 8], B can be metal ions, such as Pb2+ and Sn2+ [9, 10, 11, 12], and X is usually halide ions [13], and such a class of materials is known as organic–inorganic hybrid perovskites. It was reported that a stable structure of hybrid perovskites can form where 0.81 <
\n
However, a vast array of prior research on perovskite optoelectronic devices has been centered on polycrystalline films. The polycrystalline samples usually suffer from grain boundaries, relatively higher trap densities and defects, and low stability, which would obviously obscure their potential in applications [35, 36, 37]. More recently, researchers have paid more attention to perovskite single crystals, which possess promising characteristics of no grain boundaries [15], relatively low trap density [38], large charge carrier mobility, and long carrier diffusion length [39, 40, 41]. In this regard, extensive efforts are being devoted to developing effective methods to improve the perovskite crystal quality and optimize the device performance. Existing in the forms of bulk or thin crystals, perovskite crystal samples have been widely applied in various optoelectronic applications [39, 42], and have made rapid and great strides in research progress [43, 44, 45, 46].
\nIn this chapter, we aim to summarize the recent achievements, ongoing progress, and the challenges to date in the area of hybrid perovskite single crystals, practically MA-based ones (MAPbX3, X = Cl, Br, and I), from the perspective of both materials and devices with an emphasis placed on the optimization of crystal quality, and provide an outlook on the opportunities offered by this emerging family of materials in field of optoelectronic applications.
\nAccording to the lower solubility of MAPbX3 in HX (X = Cl, Br, and I) solution as the temperature decreases, Tao’s group introduced the STL method to synthesize a MAPbI3 bulk single crystal (\nFigure 2a\n) [47]. After the reaction between methylamine (CH3NH2) and hydro-iodic acid (HI) in a cold atmosphere, the obtained white microcrystal MAI was reacted with Pb(CH3COOH)2∙3H2O in aqueous HI, and the solution was then cooled to 40°C. A 10 mm × 10 mm × 8 mm black MAPbI3 single crystal was grown in about one month (\nFigure 2b\n). Lin’s group discovered a more efficient way, and they synthesized the single crystals with a size of 5 mm in just around 10 days [48]. Lin et al. selected high-quality seeds and dropped them back into fresh solution and obtained single crystals sized up to 1 cm (\nFigure 2c\n). Furthermore, MAPbBr3 − xClx and MAPbI3 − xBrx mixed-halide perovskite crystals were studied using such method [49]. Hydro-bromic acid with hydrochloric acid or hydro-iodic acid were mixed in different molar ratios into methylamine and lead (II) acetate solution to fabricate single-halide and mixed-halide perovskite crystals (\nFigure 2d\n). The time-consuming factor is the biggest drawback of this method, which has indirectly led to the domination of other crystallization methods.
\n\n
As a radically faster perovskite crystal synthesis approach, the ITC method has widely been applied in recent years. It was observed that the exhibited crystals from such method can be shape-controlled, higher quality, and obtained quicker compared with other growth techniques. Bakr et al. introduced this method to rapidly grow high-quality bulk crystals [50]. As shown in \nFigure 2e\n, an orange MAPbBr3 crystal and a black MAPbI3 crystal were grown within 3 hours. Chen’s group further studied the effect of molar ratio of MAX and PbX2 in the precursor solutions on the crystal quality [52], e.g., perovskite crystals with different sizes and shapes were obtained after a 6-hour ITC crystallization process when changing the MAX: PbX2 ratios from 1:1 to 2:1.
\nWith an aim of growing a large-sized bulk perovskite crystal, such ITC method was further modified. Using such technique, the strategy of incorporation of seed crystal growth has been proven to be favorable for single crystals as large as convenient. Liu’s group reported various large-sized perovskite crystals via using the modified ITC method, from which a number of larger-sized crystal (7 mm) were obtained through choosing good-quality seed crystals and repeating and carefully controlling the ITC process several times (\nFigure 2f\n). Moreover, Liu’s group also successfully grew MAPb(BrxI1 − x)3 single crystals with a finely-tuned bandgap [51]. The application of the different solubility of different perovskite single crystals at varying temperatures contributes to the time-saving feature of such ITC method.
\nAnother main method to grow perovskite crystals is the AVC method (\nFigure 2g\n), which was first introduced from Bakr’s group [15]. In this method, the solvent plays a significant role because two or more solvents should be selected, of which one should be a good solvent that is less volatile, and the other is a bad solvent that is more volatile. The principle of this method can be described as follows: when the bad solvent slowly diffuses into the precursor solution, the proficiency of the crystal formation increases at the bottom of the sample vial owing to the insolubility of the material in the bad solvent. Other groups, like Loi’s group and Cao’s group, also applied this method to obtain the high-quality crystals [38, 53]. Although the AVC method costs more time than the ITC method, its temperature-irrelevant characteristic is appealing to its widespread use.
\nBulk perovskite single crystals with thick sizes may cause the increase of charge recombination, which would lead to the degradation of their device performance and impede the practical applications. In this regard, growing thin perovskite crystals with a large area represents an effective approach to overcome the above obstacle and thus advances the further practical applications. Bakr et al. introduced a cavitation-triggered asymmetrical crystallization strategy, in which a very short ultrasonic pulse (≈1 s) was applied in the solution to reach a low supersaturation level with anti-solvent vapor diffusion and a thin crystal with several-micrometers grew on the substrates within hours (\nFigure 3a\n) [54]. Liu’s group synthesized perovskite crystal wafers with a much thinner thickness using a dynamic flow micro-reactor system [55]. They put two thin glass slides in parallel into a container with a predefined separation to grow single crystals within the slit channel, as shown in \nFigure 3b\n. Su’s group further used a space-limited ITC method and grew a 120-cm2 single crystal on fluorine-doped tin oxide (FTO)-coated glass, of which the operation and the obtained 0.4-mm-thin single crystal are shown in \nFigure 3c\n [56]. Meanwhile, Wan et al. reported a space-confined solution-processed method to grow the perovskite single-crystalline films with adjustable thickness from nanometers to micrometers (\nFigure 3d\n) [57]. Benefitting from the capillary pressure, the perovskite precursor solution filled the whole space between two clean flat substrates, which were clipped together and dipped in the solution.
\n\n
Currently, more promising approaches have been employed to grow thin single crystals with high quality and large scale. A one-step printing geometrically-confined lateral crystal growth method (\nFigure 3e\n) was introduced by Sung’s group to obtain a large-scaled single crystal [58]. During the process, a cylindrical metal roller with a flexible poly-(dimethyl-siloxane) (PDMS) mold was wrapped and then rolled on a preheated SiO2 substrate (180°C) with an ink supplier filled with the precursor solution. Alternatively, millimeter-sized single crystals were synthesized by Song’s group by a facile seed-inkjet-printing approach (\nFigure 3f\n) [59]. Perovskite precursor solution was injected onto a silicon wafer, and then the ordered seeds were formed on the substrate with the evaporation of the droplets. Thereafter, the substrate with a saturated perovskite solution was covered and the single crystals can be grew as the solvent dried at room temperature. Seeds were used to inhibit the random nucleation and trigger the growth of single crystals.
\nAs discussed above, some optimized space-limited approaches have been introduced and developed to synthesize perovskite thin crystals in recent years. Especially, size−/thickness-controlled thin crystals have also been widely used in various optoelectronic devices. With the aim to growing large-scaled and thickness-controlled thin crystals with longer carrier diffusion lengths, fewer defects, and higher efficiency, more promising strategies will be rewarding in the future.
\nThere are two normal ways to study the optical properties of hybrid perovskite crystals: absorption and PL measurements. Bakr et al. characterized the steady-state absorption and PL properties for MAPbBr3 and MAPbI3 crystals, as shown in \nFigure 4a\n and \nb\n [50]. Sharp band edges were observed in the absorption plots and the band gap values were determined to be 2.18 eV for MAPbBr3 crystals and 1.51 eV for MAPbI3 crystals; while the PL intensity peaks are located at 574 nm for MAPbBr3 and 820 nm for MAPbI3. As for the MAPbCl3 one, absorption measurement result revealed an edge at 435 nm (\nFigure 4c\n) [60]. Clearly, the optical absorption of perovskite crystals exhibited a clear-cut sharp band edge, which indicated that the single crystals are predominantly free from grain boundaries and have relatively low structural defects and trap densities.
\nSteady-state absorption (
More recently, there have been more broad publications on the apparent disparity in optical properties (i.e., absorption and PL) between perovskite single crystals and thin films, which can be attributed to the incorrect measurements as a result of reabsorption effects. Snaith’s group performed a detailed investigation of the optical properties of MAPbBr3 crystals as compared to those of the polycrystalline films by employing light transmission spectroscopy, ellipsometry, and spatially resolved and time-resolved PL spectroscopy [61]. They showed that the optical properties of the perovskite crystals were almost identical to those of polycrystalline films, and their observations indicated that the perovskite polycrystalline films were much closer to possessing ‘single-crystal-like’ optoelectronic properties than previously thought, and also highlighted the discrepancies in the estimation of trap densities from the electronic and optical methods (\nFigure 4d\n). For the further development of perovskite crystals, more detailed experimental investigations combined with theoretical calculations that focus on the optical features are required, which would assist in the preparation of the high-quality perovskite single crystals and the development of the high-performance device applications.
\nAs for hybrid perovskite crystals, in addition to the remarkable optical properties, their promising electrical properties have caught the great attention. In general, there are five common methods to measure the transport mobilities in perovskite crystals, including the space charge limited current (SCLC), time-of-flight (TOF), Hall Effect, THz pulse and field-effect transistor (FET) measurement methods. Among these methods, the SCLC method is widely employed to determine the carrier mobility and trap density of perovskite crystals. The current–voltage (
\n
Although the above measurement approaches have been widely used in the perovskite crystals, the obtained results from different groups are sometimes different. Sargent et al. demonstrated that one main challenge that may explain these order-of-magnitude discrepancies is that the Hall Effect, TOF, and SCLC methods all probe the mobilities near the respective Fermi levels during the experiments, and the (non-equilibrium, high-injection-level) Fermi level is widely different in each experiment [64]. In this regard, they developed a contactless method to measure the mobility of a perovskite crystal directly [64]. Plus, THz pulse measurement was also used to estimate
Carrier lifetime (
The widely studied hybrid perovskite solar cells with high performance are usually made from polycrystalline films; however, the current studies have also focused on the developments and optimization of single crystal perovskite solar cells, owing to their significant advantages. Huang et al. fabricated photovoltaic devices based on MAPbI3 bulk crystals by depositing gold (Au) as anodes and gallium (Ga) as cathodes (\nFigure 6a\n) [63]. A red-shift of 50 nm of the EQE cutoff to 850 nm showed that MAPbI3 crystals increased the upper limit of short-circuit current density (
\n
In addition to the vertical-structured solar cells, Huang’s group also fabricated the lateral structure perovskite crystal device (\nFigure 6d\n) [73], which showed a
Photodetectors which can convert incident light into electrical signals are critical for various industrial and scientific applications. To evaluate the photodetector performance, several parameters are important, including responsivity (
Quantity | \nUnit | \nDefinition | \n
---|---|---|
Photocurrent ( | \nA | \nCurrent through a photodetector resulting from illumination. | \n
Dark-current ( | \nA | \nCurrent through a device in the absence of illumination. | \n
Photoresponsivity ( | \nA/W | \n\n | \n
Detectivity ( | \nJones | \n\n | \n
Gain ( | \n— | \n\n | \n
Linear dynamic range ( | \ndB | \nLDR is calculated by LDR = 20log( | \n
External quantum efficiency ( | \n% | \nCarrier number divided by the number of incident photons. | \n
Internal quantum efficiency ( | \n% | \nIt is the ratio of carrier number to the number of incident photons that are absorbed by the device. | \n
Parameters for evaluating the perovskite single crystal photodetectors.
Huang’s group fabricated perovskite crystal photodetectors that exhibited a high sensitivity capacity, which led to a narrow-band photo-response with a full width at half maximum (FWHM) of less than 20 nm under V = −1 V (\nFigure 7a\n) [49].
\n
Although perovskite crystal photodetectors have shown better performance, macroscopic crystals cannot be grown on a planar substrate, restricting their potential for device integration. To overcome this shortcoming, Bakr et al. grew large-area planar-integrated crystal films onto the ITO-patterned substrates (\nFigure 7c\n) [42], and the fabricated photodetector possessed a high
UV detection is a key technology in the fields of flame detection [80], remote security monitoring [81], environmental monitoring [82], and so forth. Researchers have endeavored to develop UV photodetectors based on perovskite crystals considering their excellent UV absorption properties. Visible-blind UV photodetectors based on MAPbCl3 crystals a suitable bandgap of about 3.11 eV were fabricated (\nFigure 8a\n) [60], and the device showed the dark current as low as 4.15 × 10−7 A at 15 V and a drastically high stability (\nFigure 8b\n). Planar-integrated MAPbCl3 crystal UV photodetectors on ITO-deposited glass substrate were reported by Sargent et al. (\nFigure 8c\n) [83], which showed decreased
\n
NIR photodetectors have widespread uses in telecommunications [86], as well as thermal and biological imaging [87, 88, 89, 90]. Meredith’s group demonstrated the perovskite crystal that overcame the large bandgap and presented photodetectors with performance metrics appropriate for NIR detection by using the trap-related linear sub-gap absorption (\nFigure 8e\n) [84]. A strong NIR photo-response was achieved in photodiodes based on MAPbI3 crystals illuminated by a continuous 808-nm laser (∼10 mW/cm2). The photodiodes could also respond to a laser with a wavelength as long as 1064 nm (\nFigure 8f\n).
\nIn addition to the common light detections from UV to IR, perovskite crystals have been employed for the detection of X-rays, which have important applications in medical diagnostics, clinical treatment, and the non-destructive testing of products [53]. Huang et al. fabricated a sensitive MAPbBr3 crystal X-ray detector with the structure of Au/MAPbBr3/crystal/C60/BCP/Ag or Au (\nFigure 9a\n) [53]. Through reducing the bulk defects and passivating surface traps, the devices showed a detection efficiency of 16.4% at a near zero bias under irradiation with continuum X-ray energy up to 50 keV. The lowest detectable X-ray dose rate was 0.5 μGyair/s with a sensitivity of 80 μC/Gyaircm2, which is four times higher than the sensitivity achieved in
\n
Similar to X-ray detectors, the
Huang’s group further reported a Cl− dopant compensation of MAPbBr3 single crystal process to fabricate a low-cost
With the exceptional PL efficiency and high color purity, perovskite crystals can also perform as high-performance LEDs [97]. Most of the existing perovskite LEDs employ a polycrystalline film with sizes of nanometers to micrometers, and coherent light emission is a challenge [98]. In Yu’s work, the LEDs with the structure of ITO/MAPbBr3 micro-platelet/Au cathode had the turn-on voltage of about 1.8 V and could last for at least 54 h with a luminance of ∼5000 cd/m2 (\nFigure 10a\n) [99].
\n\n
The excellent properties, including a small trap density, long lifetime and electron–hole diffusion length, and large carrier mobility, also make perovskite crystals suitable for laser devices with low lasing thresholds and high qualities. Xiong’s group grew typical MAPbI3 triangular nano-platelets and optically pumped them by a femtosecond-pulsed laser (\nFigure 10b\n) [100], and the peaks centered at
Hybrid perovskite single crystals have shown great potential in high-performance optoelectronic devices; however, several challenges and issues still remain in terms of their practical applications. They mainly include (1) the effects of surface defects, (2) the large-area fabrication, as well as (3) the stability of the perovskite single crystal devices and (4) the health and environmental concerns.
\nThe absence of grain boundaries makes perovskite crystals acquire better optical and charge transport properties than their polycrystalline counterparts. However, the surface of crystals usually possesses lots of chemical impurities, dangling bonds, surface dislocations, and under-coordinated atoms, and becomes disordered owing to hydration, thus decreasing the carrier mobility and carrier diffusion length and promote the recombination of carriers near the crystal surface [76, 104, 105, 106]. Thus, the further decrease of defects, especially the surface defects, is required, aiming to gain high-quality perovskite crystals. To realize high-performance optoelectronic devices based on perovskite crystals with low-level surface defects, more research should be carried out on the surface passivation.
\nHybrid perovskite thin crystals are freer of grain boundaries and exhibit better transport properties than those of the polycrystalline candidates, so their large-area fabrication will ensure a promising future. However, the embedding of volatile and vulnerable organic components on fragile inorganic framework makes them difficult to be fabricated with a large area by deposition techniques or solution-based methods [42, 54]. Furthermore, thin crystals were grown directly on conductive substrates like FTO- or ITO-glass [42, 56], and tailored substrates, such as SiO2/Si [97], which provide in-situ growth for thin crystals and be directly made into devices. Nevertheless, these large-area thin crystals have rough surfaces and a great number of surface defects, and thus their optoelectronic properties remain inferior to the bulk counterparts. Further optimization of growth methods for large-area thin crystals is needed for industry productions in future.
\nLow stability of the current hybrid perovskite crystal devices hinders their broad practical application. Several factors that affect the device stability, like ion migration [107, 108], can cause hysteresis and photo-induced phase separation, and the interaction between single crystals and their surroundings lies in the degradation of perovskite by humidity and light [109, 110, 111]. Therefore, to further enhance the stability of single crystal devices, optimized device structures should be designed to control the ion migrations. Meanwhile, various compositions and interface engineering approaches are also intensively investigated to confront this critical issue. In addition, encapsulation has been demonstrated to be a valid method to protect hybrid perovskite devices.
\nThe growth of hybrid perovskite crystals adopt heavy metal ions, like lead (Pb) or tin (Sn), and organic functional groups, which can impact both the environment and human health. This critical issue needs to be overcome, aiming for further commercialization. As for the common MAPbI3 perovskite crystal, the Pb-ion is toxic to both the human health and natural environment; while the organic solvents used during the growth process of crystals are also toxic and easily penetrate into the human body [112]. To solve these problems, capsulation and recycling are needed in the use of crystal materials and organic solvents. Furthermore, other alternative metals to Pb, with a lower toxicity, are also being studied, such as bismuth and antimony [113, 114], and thus, the optoelectronic properties of these Pb-free perovskite crystals need to be explored further for device applications.
\nMore recently, hybrid perovskite crystals, having different dimensional forms: bulk and thin crystals, and micro−/nano-plates, have been widely explored as functional layers for optoelectronic devices owing to their excellent physical properties combined with the advantage of ease of processing. Although these types of devices are still in the early stages of development, a strong potential for a variety of technological and commercial applications clearly remains. Here, we presented a comprehensive overview of the recent advances in hybrid perovskite crystals with respect to the background knowledge on the optoelectronic properties and charge transport dynamics of crystals, and their applications in the area of optoelectronic devices, and a fundamental understanding of the device performance. We summarized the main growth methods for the bulk crystals and also some modified and optimized approaches to synthesize thin crystals. The detailed discussions are focused on charge transport characteristics, operation mechanisms, and challenges, aiming to provide a critical understanding of further advance in materials design and device engineering in a variety of optoelectronic technologies.
\nIn conclusion, the research progress achieved to date in the area of perovskite crystal optoelectronic devices, with the emphasis placed on challenges faced by the research community, has been summarized systematically, and finally perspective on the opportunities offered by this emerging family to photoactive materials in practical and commercial technologies is also proposed. Further exploration of high-quality perovskite crystals, combined with an in-depth understandings of working mechanism of devices, indicates a promising future for wide applications with markedly-enhanced performance.
\nThe author acknowledges support from Discovery Early Career Researcher Award (DECRA) (DE180100167) from the Australian Research Council (ARC).
\nThere are no conflicts to declare.
In line with the Principles of Transparency and Best Practice in Scholarly Publishing, below is a more detailed description of IntechOpen's Advertising Policy.
",metaTitle:"Advertising Policy",metaDescription:"IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.",metaKeywords:null,canonicalURL:"/page/advertising-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"1. IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.
\\n\\n2. All advertisements and commercially sponsored publications are independent from editorial decisions.
\\n\\n3. IntechOpen does not endorse any product or service marked as an advertisement on IntechOpen website.
\\n\\n4. IntechOpen has blocked all the inappropriate types of advertising.
\\n\\n5. IntechOpen has blocked advertisement of harmful products or services.
\\n\\n6. Advertisements and editorial content are clearly distinguishable.
\\n\\n7. Editorial decisions will not be influenced by current or potential advertisers and will not be influenced by marketing decisions.
\\n\\n8. Advertisers have no control or influence over the results of searches a user may conduct on the website by keyword or topic search.
\\n\\n9. Types of advertisments:
\\n\\n- Advertisements in the Physical Sciences, Engineering and Technology, and Social Sciences and Humanities sections of the IntechOpen website are programmatic (based on user behaviour such as web pages visited, content viewed, etc.)
\\n\\n- Advertisements in the Life Sciences and Health Sciences sections of the IntechOpen website are programmatic as well as contextual based on the content of the respective books and chapters. IntechOpen's third party partner eHealthcare Solutions (EHS) is a unique marketing platform that specializes in connecting niche audiences with healthcare brands.
\\n\\nYou may view their privacy policy here: https://ehealthcaresolutions.com/privacy-policy/
\\n\\n10. IntechOpen Advertising Sales department makes the decisions about the types of advertisements to include or exclude. Placement of advertising is at the discretion of IntechOpen. IntechOpen retains the right to reject and/or request modifications to the advertisement. An advertisement that is visible online, will be withdrawn from the site at any time if the Editor(s) or Author(s) request its removal.
\\n\\n11. Users can make decisions about accepting advertisements. Users can block all the advertisements by using ad blockers. Users can send all the complaints about advertising to: info@intechopen.com.
\\n\\nPolicy last updated: 2021-04-28
\\n"}]'},components:[{type:"htmlEditorComponent",content:'1. IntechOpen partners with third-party companies to serve ads and/or collect certain information when you visit our website. These companies may collect non-personally identifiable information (not including your name, address, email address or telephone number) during your visit to IntechOpen's website.
\n\n2. All advertisements and commercially sponsored publications are independent from editorial decisions.
\n\n3. IntechOpen does not endorse any product or service marked as an advertisement on IntechOpen website.
\n\n4. IntechOpen has blocked all the inappropriate types of advertising.
\n\n5. IntechOpen has blocked advertisement of harmful products or services.
\n\n6. Advertisements and editorial content are clearly distinguishable.
\n\n7. Editorial decisions will not be influenced by current or potential advertisers and will not be influenced by marketing decisions.
\n\n8. Advertisers have no control or influence over the results of searches a user may conduct on the website by keyword or topic search.
\n\n9. Types of advertisments:
\n\n- Advertisements in the Physical Sciences, Engineering and Technology, and Social Sciences and Humanities sections of the IntechOpen website are programmatic (based on user behaviour such as web pages visited, content viewed, etc.)
\n\n- Advertisements in the Life Sciences and Health Sciences sections of the IntechOpen website are programmatic as well as contextual based on the content of the respective books and chapters. IntechOpen's third party partner eHealthcare Solutions (EHS) is a unique marketing platform that specializes in connecting niche audiences with healthcare brands.
\n\nYou may view their privacy policy here: https://ehealthcaresolutions.com/privacy-policy/
\n\n10. IntechOpen Advertising Sales department makes the decisions about the types of advertisements to include or exclude. Placement of advertising is at the discretion of IntechOpen. IntechOpen retains the right to reject and/or request modifications to the advertisement. An advertisement that is visible online, will be withdrawn from the site at any time if the Editor(s) or Author(s) request its removal.
\n\n11. Users can make decisions about accepting advertisements. Users can block all the advertisements by using ad blockers. Users can send all the complaints about advertising to: info@intechopen.com.
\n\nPolicy last updated: 2021-04-28
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"6700",title:"Dr.",name:"Abbass A.",middleName:null,surname:"Hashim",slug:"abbass-a.-hashim",fullName:"Abbass A. Hashim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/6700/images/1864_n.jpg",biography:"Currently I am carrying out research in several areas of interest, mainly covering work on chemical and bio-sensors, semiconductor thin film device fabrication and characterisation.\nAt the moment I have very strong interest in radiation environmental pollution and bacteriology treatment. The teams of researchers are working very hard to bring novel results in this field. I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. He is an expert in structural, absorptive, catalytic and photocatalytic properties, in structural organization and dynamic features of ionic liquids, in magnetic interactions between paramagnetic centers. The author or co-author of 3 books, over 200 articles and reviews in scientific journals and books. He is an actual member of the International EPR/ESR Society, European Society on Quantum Solar Energy Conversion, Moscow House of Scientists, of the Board of Moscow Physical Society.",institutionString:null,institution:{name:"Semenov Institute of Chemical Physics",country:{name:"Russia"}}},{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62389/images/3413_n.jpg",biography:"Dr. Ali Demir Sezer has a Ph.D. from Pharmaceutical Biotechnology at the Faculty of Pharmacy, University of Marmara (Turkey). He is the member of many Pharmaceutical Associations and acts as a reviewer of scientific journals and European projects under different research areas such as: drug delivery systems, nanotechnology and pharmaceutical biotechnology. Dr. Sezer is the author of many scientific publications in peer-reviewed journals and poster communications. Focus of his research activity is drug delivery, physico-chemical characterization and biological evaluation of biopolymers micro and nanoparticles as modified drug delivery system, and colloidal drug carriers (liposomes, nanoparticles etc.).",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"61051",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"100762",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"St David's Medical Center",country:{name:"United States of America"}}},{id:"107416",title:"Dr.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Texas Cardiac Arrhythmia",country:{name:"United States of America"}}},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/64434/images/2619_n.jpg",biography:"My name is Angkoon Phinyomark. I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. His current research interests include the areas of mobile communication systems and channel modeling in addition to atmospheric optical communications, adaptive optics and statistics",institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6669},{group:"region",caption:"Middle and South America",value:2,count:5955},{group:"region",caption:"Africa",value:3,count:2457},{group:"region",caption:"Asia",value:4,count:12710},{group:"region",caption:"Australia and Oceania",value:5,count:1016},{group:"region",caption:"Europe",value:6,count:17716}],offset:12,limit:12,total:134177},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish",topicId:"7,21,23"},books:[{type:"book",id:"11434",title:"Indigenous Populations - Perspectives From Scholars and Practitioners in Contemporary Times",subtitle:null,isOpenForSubmission:!0,hash:"c0d1c1c93a36fd9d726445966316a373",slug:null,bookSignature:"Dr. Sylvanus Gbendazhi Barnabas",coverURL:"https://cdn.intechopen.com/books/images_new/11434.jpg",editedByType:null,editors:[{id:"293764",title:"Dr.",name:"Sylvanus",surname:"Barnabas",slug:"sylvanus-barnabas",fullName:"Sylvanus Barnabas"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11782",title:"Personality Traits - The Role in Psychopathology",subtitle:null,isOpenForSubmission:!0,hash:"d3a491e5194cad4c59b900dd57a11842",slug:null,bookSignature:" Vladimir V. Kalinin",coverURL:"https://cdn.intechopen.com/books/images_new/11782.jpg",editedByType:null,editors:[{id:"31572",title:null,name:"Vladimir V.",surname:"Kalinin",slug:"vladimir-v.-kalinin",fullName:"Vladimir V. Kalinin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11444",title:"Happiness - Biopsychosocial and Anthropological Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"fa84e7fc3611e5428e070239dcf5a93f",slug:null,bookSignature:"Dr. Floriana Irtelli and Prof. Fabio Gabrielli",coverURL:"https://cdn.intechopen.com/books/images_new/11444.jpg",editedByType:null,editors:[{id:"174641",title:"Dr.",name:"Floriana",surname:"Irtelli",slug:"floriana-irtelli",fullName:"Floriana Irtelli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11601",title:"Econometrics - Recent Advances and Applications",subtitle:null,isOpenForSubmission:!0,hash:"bc8ab49e2cf436c217a49ca8c12a22eb",slug:null,bookSignature:"Dr. Brian Sloboda",coverURL:"https://cdn.intechopen.com/books/images_new/11601.jpg",editedByType:null,editors:[{id:"452331",title:"Dr.",name:"Brian",surname:"Sloboda",slug:"brian-sloboda",fullName:"Brian Sloboda"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12239",title:"Topics on Globalization",subtitle:null,isOpenForSubmission:!0,hash:"43443244d8385c57f1424d5d37c91788",slug:null,bookSignature:"Prof. Elsadig Musa Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/12239.jpg",editedByType:null,editors:[{id:"268621",title:"Prof.",name:"Elsadig",surname:"Ahmed",slug:"elsadig-ahmed",fullName:"Elsadig Ahmed"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11779",title:"Non-government Organizations - New Perspectives",subtitle:null,isOpenForSubmission:!0,hash:"c109a472a9e0ea8398ae95e2d21be039",slug:null,bookSignature:"Prof. Vito Bobek and Dr. Tatjana Horvat",coverURL:"https://cdn.intechopen.com/books/images_new/11779.jpg",editedByType:null,editors:[{id:"128342",title:"Prof.",name:"Vito",surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11477",title:"Public Economics - New Perspectives and Uncertainty",subtitle:null,isOpenForSubmission:!0,hash:"a8e6c515dc924146fbd2712eb4e7d118",slug:null,bookSignature:"Dr. Habtamu Alem",coverURL:"https://cdn.intechopen.com/books/images_new/11477.jpg",editedByType:null,editors:[{id:"414400",title:"Dr.",name:"Habtamu",surname:"Alem",slug:"habtamu-alem",fullName:"Habtamu Alem"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11436",title:"Beauty - Evolutionary, Social and Cultural Perspectives on Attractiveness",subtitle:null,isOpenForSubmission:!0,hash:"8f2773e5d4ffe767f38dd15712258e8c",slug:null,bookSignature:"Dr. Farid Pazhoohi",coverURL:"https://cdn.intechopen.com/books/images_new/11436.jpg",editedByType:null,editors:[{id:"470837",title:"Dr.",name:"Farid",surname:"Pazhoohi",slug:"farid-pazhoohi",fullName:"Farid Pazhoohi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11443",title:"Empathy - Advanced Research and Applications",subtitle:null,isOpenForSubmission:!0,hash:"4c1042dfe15aa9cea6019524c4cbff38",slug:null,bookSignature:"Ph.D. Sara Ventura",coverURL:"https://cdn.intechopen.com/books/images_new/11443.jpg",editedByType:null,editors:[{id:"227763",title:"Ph.D.",name:"Sara",surname:"Ventura",slug:"sara-ventura",fullName:"Sara Ventura"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11437",title:"Social Media - Risks and Opportunities",subtitle:null,isOpenForSubmission:!0,hash:"000e31f2e2f7295805e9a3864158ad63",slug:null,bookSignature:"Dr. Shafizan Mohamed and Dr. Shazleen Mohamed",coverURL:"https://cdn.intechopen.com/books/images_new/11437.jpg",editedByType:null,editors:[{id:"302450",title:"Associate Prof.",name:"Shafizan",surname:"Mohamed",slug:"shafizan-mohamed",fullName:"Shafizan Mohamed"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11769",title:"Multiculturalism and Interculturalism",subtitle:null,isOpenForSubmission:!0,hash:"6c4bda24f278d74f943f2155f13f4d73",slug:null,bookSignature:"Dr. Muhammad Mohiuddin, Dr. Tareque Aziz and Dr. Sreenivasan Jayashree",coverURL:"https://cdn.intechopen.com/books/images_new/11769.jpg",editedByType:null,editors:[{id:"418514",title:"Dr.",name:"Muhammad",surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12109",title:"Identifying Occupational Stress and Coping Strategies",subtitle:null,isOpenForSubmission:!0,hash:"09a2f5fe50b90b20637b7aceccf1cfdd",slug:null,bookSignature:"Dr. Kavitha Palaniappan",coverURL:"https://cdn.intechopen.com/books/images_new/12109.jpg",editedByType:null,editors:[{id:"311189",title:"Dr.",name:"Kavitha",surname:"Palaniappan",slug:"kavitha-palaniappan",fullName:"Kavitha Palaniappan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:38},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:13},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:24},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:65},{group:"topic",caption:"Environmental Sciences",value:12,count:10},{group:"topic",caption:"Immunology and Microbiology",value:13,count:16},{group:"topic",caption:"Materials Science",value:14,count:25},{group:"topic",caption:"Mathematics",value:15,count:11},{group:"topic",caption:"Medicine",value:16,count:116},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:6},{group:"topic",caption:"Neuroscience",value:18,count:4},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:9},{group:"topic",caption:"Physics",value:20,count:9},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:26},popularBooks:{featuredBooks:[],offset:0,limit:12,total:null},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10858",title:"MOOC (Massive Open Online Courses)",subtitle:null,isOpenForSubmission:!1,hash:"d32f86793bc72dde32532f509b1ec5b0",slug:"mooc-massive-open-online-courses-",bookSignature:"Dragan Cvetković",coverURL:"https://cdn.intechopen.com/books/images_new/10858.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1677,editors:[{id:"101330",title:"Dr.",name:"Dragan",middleName:"Mladen",surname:"Cvetković",slug:"dragan-cvetkovic",fullName:"Dragan Cvetković"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1337,editors:[{id:"71579",title:"Prof.",name:"Berend",middleName:null,surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10755",title:"Corporate Governance",subtitle:"Recent Advances and Perspectives",isOpenForSubmission:!1,hash:"ffe06d1d5c4bf0fc2e63511825fe1257",slug:"corporate-governance-recent-advances-and-perspectives",bookSignature:"Okechukwu Lawrence Emeagwali and Feyza Bhatti",coverURL:"https://cdn.intechopen.com/books/images_new/10755.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:1309,editors:[{id:"196317",title:"Associate Prof.",name:"Okechukwu Lawrence",middleName:null,surname:"Emeagwali",slug:"okechukwu-lawrence-emeagwali",fullName:"Okechukwu Lawrence Emeagwali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",subtitle:null,isOpenForSubmission:!1,hash:"9e77514288e7394f1e6cd13481af3509",slug:"environmental-impact-and-remediation-of-heavy-metals",bookSignature:"Hosam M. Saleh and Amal I. Hassan",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:847,editors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10901",title:"Grapes and Wine",subtitle:null,isOpenForSubmission:!1,hash:"5d7f2aa74874444bc6986e613ccebd7c",slug:"grapes-and-wine",bookSignature:"Antonio Morata, Iris Loira and Carmen González",coverURL:"https://cdn.intechopen.com/books/images_new/10901.jpg",publishedDate:"June 15th 2022",numberOfDownloads:2273,editors:[{id:"180952",title:"Prof.",name:"Antonio",middleName:null,surname:"Morata",slug:"antonio-morata",fullName:"Antonio Morata"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11080",title:"Engineering Principles",subtitle:"Welding and Residual Stresses",isOpenForSubmission:!1,hash:"6c07a13a113bce94174b40096f30fb5e",slug:"engineering-principles-welding-and-residual-stresses",bookSignature:"Kavian Omar Cooke and Ronaldo Câmara Cozza",coverURL:"https://cdn.intechopen.com/books/images_new/11080.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:591,editors:[{id:"138778",title:"Dr.",name:"Kavian",middleName:"Omar",surname:"Cooke",slug:"kavian-cooke",fullName:"Kavian Cooke"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11332",title:"Essential Oils",subtitle:"Advances in Extractions and Biological Applications",isOpenForSubmission:!1,hash:"742e6cae3a35686f975edc8d7f9afa94",slug:"essential-oils-advances-in-extractions-and-biological-applications",bookSignature:"Mozaniel Santana de Oliveira and Eloisa Helena de Aguiar Andrade",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:515,editors:[{id:"195290",title:"Ph.D.",name:"Mozaniel",middleName:null,surname:"Santana De Oliveira",slug:"mozaniel-santana-de-oliveira",fullName:"Mozaniel Santana De Oliveira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11029",title:"Hepatitis B",subtitle:null,isOpenForSubmission:!1,hash:"609701f502efc3538c112ff47a2c2119",slug:"hepatitis-b",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/11029.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:413,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9537",title:"Human Rights in the Contemporary World",subtitle:null,isOpenForSubmission:!1,hash:"54f05b93812fd434f3962956d6413a6b",slug:"human-rights-in-the-contemporary-world",bookSignature:"Trudy Corrigan",coverURL:"https://cdn.intechopen.com/books/images_new/9537.jpg",publishedDate:"June 8th 2022",numberOfDownloads:2194,editors:[{id:"197557",title:"Dr.",name:"Trudy",middleName:null,surname:"Corrigan",slug:"trudy-corrigan",fullName:"Trudy Corrigan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11371",title:"Cerebral Circulation",subtitle:"Updates on Models, Diagnostics and Treatments of Related Diseases",isOpenForSubmission:!1,hash:"e2d3335445d2852d0b906bb9750e939f",slug:"cerebral-circulation-updates-on-models-diagnostics-and-treatments-of-related-diseases",bookSignature:"Alba Scerrati, Luca Ricciardi and Flavia Dones",coverURL:"https://cdn.intechopen.com/books/images_new/11371.jpg",publishedDate:"June 23rd 2022",numberOfDownloads:341,editors:[{id:"182614",title:"Dr.",name:"Alba",middleName:null,surname:"Scerrati",slug:"alba-scerrati",fullName:"Alba Scerrati"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"11043",title:"Endometriosis",subtitle:"Recent Advances, New Perspectives and Treatments",isOpenForSubmission:!1,hash:"7baf1c70b11d41400bb9302ae9411ca4",slug:"endometriosis-recent-advances-new-perspectives-and-treatments",bookSignature:"Giovana Ap. Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/11043.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"185930",title:"Associate Prof.",name:"Giovana",middleName:null,surname:"Gonçalves",slug:"giovana-goncalves",fullName:"Giovana Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10536",title:"Campylobacter",subtitle:null,isOpenForSubmission:!1,hash:"c4b132b741dd0a2ed539b824ab63965f",slug:"campylobacter",bookSignature:"Guillermo Tellez-Isaias and Saeed El-Ashram",coverURL:"https://cdn.intechopen.com/books/images_new/10536.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"73465",title:"Dr.",name:"Guillermo",middleName:null,surname:"Téllez",slug:"guillermo-tellez",fullName:"Guillermo Téllez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10798",title:"Starch",subtitle:"Evolution and Recent Advances",isOpenForSubmission:!1,hash:"f197f6062c1574a9a90e50a369271bcf",slug:"starch-evolution-and-recent-advances",bookSignature:"Martins Ochubiojo Emeje",coverURL:"https://cdn.intechopen.com/books/images_new/10798.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11083",title:"Hazardous Waste Management",subtitle:null,isOpenForSubmission:!1,hash:"d553bd4f6f1c4b115ca69bd19faac7dc",slug:"hazardous-waste-management",bookSignature:"Rajesh Banu Jeyakumar, Kavitha Sankarapandian and Yukesh Kannah Ravi",coverURL:"https://cdn.intechopen.com/books/images_new/11083.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"218539",title:"Dr.",name:"Rajesh Banu",middleName:null,surname:"Jeyakumar",slug:"rajesh-banu-jeyakumar",fullName:"Rajesh Banu Jeyakumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10848",title:"Tribology of Machine Elements",subtitle:"Fundamentals and Applications",isOpenForSubmission:!1,hash:"3c4ca4c4692ca8d4fa749b4ae81ec1fa",slug:"tribology-of-machine-elements-fundamentals-and-applications",bookSignature:"Giuseppe Pintaude, Tiago Cousseau and Anna Rudawska",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"18347",title:"Prof.",name:"Giuseppe",middleName:null,surname:"Pintaude",slug:"giuseppe-pintaude",fullName:"Giuseppe Pintaude"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10856",title:"Crude Oil",subtitle:"New Technologies and Recent Approaches",isOpenForSubmission:!1,hash:"8d0a7ca35b3de95b295dc4eab39a087e",slug:"crude-oil-new-technologies-and-recent-approaches",bookSignature:"Manar Elsayed Abdel-Raouf and Mohamed Hasan El-Keshawy",coverURL:"https://cdn.intechopen.com/books/images_new/10856.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"102626",title:"Prof.",name:"Manar",middleName:null,surname:"Elsayed Abdel-Raouf",slug:"manar-elsayed-abdel-raouf",fullName:"Manar Elsayed Abdel-Raouf"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9625",title:"Spinocerebellar Ataxia",subtitle:"Concepts, Particularities and Generalities",isOpenForSubmission:!1,hash:"365a7025fd46eb45de2549bdd9d50b98",slug:"spinocerebellar-ataxia-concepts-particularities-and-generalities",bookSignature:"Patricia Bozzetto Ambrosi",coverURL:"https://cdn.intechopen.com/books/images_new/9625.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"221787",title:"Dr.",name:"Patricia",middleName:null,surname:"Bozzetto Ambrosi",slug:"patricia-bozzetto-ambrosi",fullName:"Patricia Bozzetto Ambrosi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10905",title:"Plant Defense Mechanisms",subtitle:null,isOpenForSubmission:!1,hash:"84ad5b27dde5f01dc76087d0fd6fa834",slug:"plant-defense-mechanisms",bookSignature:"Josphert Ngui Kimatu",coverURL:"https://cdn.intechopen.com/books/images_new/10905.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"224171",title:"Prof.",name:"Josphert N.",middleName:null,surname:"Kimatu",slug:"josphert-n.-kimatu",fullName:"Josphert N. Kimatu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10686",title:"Natural Gas",subtitle:"New Perspectives and Future Developments",isOpenForSubmission:!1,hash:"581763788a6a59e653a9d1d9b5a42d79",slug:"natural-gas-new-perspectives-and-future-developments",bookSignature:"Maryam Takht Ravanchi",coverURL:"https://cdn.intechopen.com/books/images_new/10686.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"2416",title:"Dr.",name:"Maryam",middleName:null,surname:"Takht Ravanchi",slug:"maryam-takht-ravanchi",fullName:"Maryam Takht Ravanchi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10988",title:"Railway Transport Planning and Manageme",subtitle:null,isOpenForSubmission:!1,hash:"5cb54cc53caedad9ec78372563c82e2c",slug:"railway-transport-planning-and-management",bookSignature:"Stefano de Luca, Roberta Di Pace and Chiara Fiori",coverURL:"https://cdn.intechopen.com/books/images_new/10988.jpg",editedByType:"Edited by",publishedDate:"June 28th 2022",editors:[{id:"271061",title:"Prof.",name:"Stefano",middleName:null,surname:"de Luca",slug:"stefano-de-luca",fullName:"Stefano de Luca"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"1376",title:"Manufacturing Engineering",slug:"textile-engineering-manufacturing-engineering",parent:{id:"296",title:"Textile Engineering",slug:"textile-engineering"},numberOfBooks:6,numberOfSeries:0,numberOfAuthorsAndEditors:115,numberOfWosCitations:534,numberOfCrossrefCitations:264,numberOfDimensionsCitations:679,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"1376",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"8542",title:"Fashion Industry",subtitle:"An Itinerary Between Feelings and Technology",isOpenForSubmission:!1,hash:"88f3d9a82a4972e4bf74cf48490eca31",slug:"fashion-industry-an-itinerary-between-feelings-and-technology",bookSignature:"Riccardo Beltramo, Annalisa Romani and Paolo Cantore",coverURL:"https://cdn.intechopen.com/books/images_new/8542.jpg",editedByType:"Edited by",editors:[{id:"257332",title:"Prof.",name:"Riccardo",middleName:null,surname:"Beltramo",slug:"riccardo-beltramo",fullName:"Riccardo Beltramo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8892",title:"Textile Manufacturing Processes",subtitle:null,isOpenForSubmission:!1,hash:"1437c101708777875352cbfd31f6241b",slug:"textile-manufacturing-processes",bookSignature:"Faheem Uddin",coverURL:"https://cdn.intechopen.com/books/images_new/8892.jpg",editedByType:"Edited by",editors:[{id:"228107",title:"Prof.",name:"Faheem",middleName:null,surname:"Uddin",slug:"faheem-uddin",fullName:"Faheem Uddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5921",title:"Textiles for Advanced Applications",subtitle:null,isOpenForSubmission:!1,hash:"4deef8de2e616f18c51985a3cafe9acb",slug:"textiles-for-advanced-applications",bookSignature:"Bipin Kumar and Suman Thakur",coverURL:"https://cdn.intechopen.com/books/images_new/5921.jpg",editedByType:"Edited by",editors:[{id:"177114",title:"Dr.",name:"Bipin",middleName:null,surname:"Kumar",slug:"bipin-kumar",fullName:"Bipin Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5086",title:"Textile Wastewater Treatment",subtitle:null,isOpenForSubmission:!1,hash:"793e019e29b364d0daa8031b0800c3c3",slug:"textile-wastewater-treatment",bookSignature:"E. Perrin Akçakoca Kumbasar and Ayşegül Ekmekci Körlü",coverURL:"https://cdn.intechopen.com/books/images_new/5086.jpg",editedByType:"Edited by",editors:[{id:"10485",title:"Dr.",name:"Emriye",middleName:"Perrin",surname:"Akcakoca Kumbasar",slug:"emriye-akcakoca-kumbasar",fullName:"Emriye Akcakoca Kumbasar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5062",title:"Non-woven Fabrics",subtitle:null,isOpenForSubmission:!1,hash:"06787f40748e81d97fb3e8c5370b35a5",slug:"non-woven-fabrics",bookSignature:"Han-Yong Jeon",coverURL:"https://cdn.intechopen.com/books/images_new/5062.jpg",editedByType:"Edited by",editors:[{id:"114618",title:"Prof.",name:"Han-Yong",middleName:null,surname:"Jeon",slug:"han-yong-jeon",fullName:"Han-Yong Jeon"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3137",title:"Eco-Friendly Textile Dyeing and Finishing",subtitle:null,isOpenForSubmission:!1,hash:"78714c655bf80050e9713a50a0581ccb",slug:"eco-friendly-textile-dyeing-and-finishing",bookSignature:"Melih Günay",coverURL:"https://cdn.intechopen.com/books/images_new/3137.jpg",editedByType:"Edited by",editors:[{id:"33126",title:"Dr.",name:"Melih",middleName:null,surname:"Gunay",slug:"melih-gunay",fullName:"Melih Gunay"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:6,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"41411",doi:"10.5772/53659",title:"Textile Dyes: Dyeing Process and Environmental Impact",slug:"textile-dyes-dyeing-process-and-environmental-impact",totalDownloads:20608,totalCrossrefCites:97,totalDimensionsCites:305,abstract:null,book:{id:"3137",slug:"eco-friendly-textile-dyeing-and-finishing",title:"Eco-Friendly Textile Dyeing and Finishing",fullTitle:"Eco-Friendly Textile Dyeing and Finishing"},signatures:"Farah Maria Drumond Chequer, Gisele Augusto Rodrigues de Oliveira, Elisa Raquel Anastácio Ferraz, Juliano Carvalho Cardoso, Maria Valnice Boldrin Zanoni and Danielle Palma de Oliveira",authors:[{id:"49040",title:"Prof.",name:"Danielle",middleName:null,surname:"Palma De Oliveira",slug:"danielle-palma-de-oliveira",fullName:"Danielle Palma De Oliveira"},{id:"149074",title:"Prof.",name:"Maria Valnice",middleName:null,surname:"Zanoni",slug:"maria-valnice-zanoni",fullName:"Maria Valnice Zanoni"},{id:"153502",title:"Ph.D.",name:"Farah",middleName:null,surname:"Chequer",slug:"farah-chequer",fullName:"Farah Chequer"},{id:"153504",title:"MSc.",name:"Gisele",middleName:null,surname:"Oliveira",slug:"gisele-oliveira",fullName:"Gisele Oliveira"},{id:"163377",title:"Dr.",name:"Juliano",middleName:null,surname:"Cardoso",slug:"juliano-cardoso",fullName:"Juliano Cardoso"},{id:"163393",title:"Dr.",name:"Elisa",middleName:null,surname:"Ferraz",slug:"elisa-ferraz",fullName:"Elisa Ferraz"}]},{id:"51191",doi:"10.5772/64140",title:"A Review of State-of-the-Art Technologies in Dye-Containing Wastewater Treatment – The Textile Industry Case",slug:"a-review-of-state-of-the-art-technologies-in-dye-containing-wastewater-treatment-the-textile-industr",totalDownloads:5365,totalCrossrefCites:26,totalDimensionsCites:45,abstract:"Recently, new single or hybrid/combined processes have attracted much attention for treatment of textile and dyeing wastewaters. These processes which may be termed as “state of the art technologies” are membrane separation processes, ultrasonic, photochemical and electrochemical processes. Although the conventional methods still have been tried with some new materials such as, new adsorbents or coagulants, employing the new generation methods such as, electrocagulation-electrooxidation, sonooxidation or photo oxidation are gaining in popularity when the treatment of textile wastewaters is discussed. The purpose of the book chapter is to bring an overview on the new treatment methods for textile wastewaters, one of the most important source of environmental pollution. Despite the fact that there is no uniform standard currently, many countries have legalized some strict discharging standards and scientists and researchers face new technologies including electrical, sonic, magnetic, optical and thermal methods. Although many researches on treatment of synthetic or real wastewaters with various methods are available, very few researches have been carried out on the cutting-edge technologies. Moreover, there are a lot of review article or book chapters on textile wastewater treatment processes individually based on each conventional process such as coagulation, adsorption, chemical oxidation, and biological decolorization. Therefore, in this part of the book, following major and minor titles are stated truly on the aforementioned new technologies. Besides, these parts are not only about cutting-edge technologies, but also related with conventional methods and their new applications in colored wastewater treatment area briefly.",book:{id:"5086",slug:"textile-wastewater-treatment",title:"Textile Wastewater Treatment",fullTitle:"Textile Wastewater Treatment"},signatures:"Serkan Arslan, Murat Eyvaz, Ercan Gürbulak and Ebubekir Yüksel",authors:[{id:"170083",title:"Associate Prof.",name:"Murat",middleName:null,surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz"},{id:"176699",title:"Dr.",name:"Ercan",middleName:null,surname:"Gürbulak",slug:"ercan-gurbulak",fullName:"Ercan Gürbulak"},{id:"176700",title:"MSc.",name:"Serkan",middleName:null,surname:"Arslan",slug:"serkan-arslan",fullName:"Serkan Arslan"},{id:"176701",title:"Prof.",name:"Ebubekir",middleName:null,surname:"Yüksel",slug:"ebubekir-yuksel",fullName:"Ebubekir Yüksel"}]},{id:"42001",doi:"10.5772/53777",title:"Cyclodextrins in Textile Finishing",slug:"cyclodextrins-in-textile-finishing",totalDownloads:5469,totalCrossrefCites:19,totalDimensionsCites:39,abstract:null,book:{id:"3137",slug:"eco-friendly-textile-dyeing-and-finishing",title:"Eco-Friendly Textile Dyeing and Finishing",fullTitle:"Eco-Friendly Textile Dyeing and Finishing"},signatures:"Bojana Voncina and Vera Vivod",authors:[{id:"33838",title:"Prof.",name:"Bojana",middleName:null,surname:"Voncina",slug:"bojana-voncina",fullName:"Bojana Voncina"}]},{id:"41409",doi:"10.5772/53911",title:"Surface Modification Methods for Improving the Dyeability of Textile Fabrics",slug:"surface-modification-methods-for-improving-the-dyeability-of-textile-fabrics",totalDownloads:7038,totalCrossrefCites:13,totalDimensionsCites:36,abstract:null,book:{id:"3137",slug:"eco-friendly-textile-dyeing-and-finishing",title:"Eco-Friendly Textile Dyeing and Finishing",fullTitle:"Eco-Friendly Textile Dyeing and Finishing"},signatures:"Sheila Shahidi, Jakub Wiener and Mahmood Ghoranneviss",authors:[{id:"58854",title:"Dr.",name:null,middleName:null,surname:"Shahidi",slug:"shahidi",fullName:"Shahidi"}]},{id:"68157",doi:"10.5772/intechopen.87968",title:"Introductory Chapter: Textile Manufacturing Processes",slug:"introductory-chapter-textile-manufacturing-processes",totalDownloads:4414,totalCrossrefCites:13,totalDimensionsCites:24,abstract:null,book:{id:"8892",slug:"textile-manufacturing-processes",title:"Textile Manufacturing Processes",fullTitle:"Textile Manufacturing Processes"},signatures:"Faheem Uddin",authors:[{id:"228107",title:"Prof.",name:"Faheem",middleName:null,surname:"Uddin",slug:"faheem-uddin",fullName:"Faheem Uddin"}]}],mostDownloadedChaptersLast30Days:[{id:"68157",title:"Introductory Chapter: Textile Manufacturing Processes",slug:"introductory-chapter-textile-manufacturing-processes",totalDownloads:4414,totalCrossrefCites:13,totalDimensionsCites:24,abstract:null,book:{id:"8892",slug:"textile-manufacturing-processes",title:"Textile Manufacturing Processes",fullTitle:"Textile Manufacturing Processes"},signatures:"Faheem Uddin",authors:[{id:"228107",title:"Prof.",name:"Faheem",middleName:null,surname:"Uddin",slug:"faheem-uddin",fullName:"Faheem Uddin"}]},{id:"41411",title:"Textile Dyes: Dyeing Process and Environmental Impact",slug:"textile-dyes-dyeing-process-and-environmental-impact",totalDownloads:20608,totalCrossrefCites:97,totalDimensionsCites:305,abstract:null,book:{id:"3137",slug:"eco-friendly-textile-dyeing-and-finishing",title:"Eco-Friendly Textile Dyeing and Finishing",fullTitle:"Eco-Friendly Textile Dyeing and Finishing"},signatures:"Farah Maria Drumond Chequer, Gisele Augusto Rodrigues de Oliveira, Elisa Raquel Anastácio Ferraz, Juliano Carvalho Cardoso, Maria Valnice Boldrin Zanoni and Danielle Palma de Oliveira",authors:[{id:"49040",title:"Prof.",name:"Danielle",middleName:null,surname:"Palma De Oliveira",slug:"danielle-palma-de-oliveira",fullName:"Danielle Palma De Oliveira"},{id:"149074",title:"Prof.",name:"Maria Valnice",middleName:null,surname:"Zanoni",slug:"maria-valnice-zanoni",fullName:"Maria Valnice Zanoni"},{id:"153502",title:"Ph.D.",name:"Farah",middleName:null,surname:"Chequer",slug:"farah-chequer",fullName:"Farah Chequer"},{id:"153504",title:"MSc.",name:"Gisele",middleName:null,surname:"Oliveira",slug:"gisele-oliveira",fullName:"Gisele Oliveira"},{id:"163377",title:"Dr.",name:"Juliano",middleName:null,surname:"Cardoso",slug:"juliano-cardoso",fullName:"Juliano Cardoso"},{id:"163393",title:"Dr.",name:"Elisa",middleName:null,surname:"Ferraz",slug:"elisa-ferraz",fullName:"Elisa Ferraz"}]},{id:"49647",title:"Fiber Selection for the Production of Nonwovens",slug:"fiber-selection-for-the-production-of-nonwovens",totalDownloads:10512,totalCrossrefCites:9,totalDimensionsCites:17,abstract:"The most significant feature of nonwoven fabric is made directly from fibers in a continuous production line. While manufacturing nonwovens, some conventional textile operations, such as carding, drawing, roving, spinning, weaving or knitting, are partially or completely eliminated. For this reason the choice of fiber is very important for nonwoven manufacturers. The commonly used fibers include natural fibers (cotton, jute, flax, wool), synthetic fibers (polyester (PES), polypropylene (PP), polyamide, rayon), special fibers (glass, carbon, nanofiber, bi-component, superabsorbent fibers). Raw materials have not only delivered significant product improvements but also benefited people using these products by providing hygiene and comfort.",book:{id:"5062",slug:"non-woven-fabrics",title:"Non-woven Fabrics",fullTitle:"Non-woven Fabrics"},signatures:"Nazan Avcioglu Kalebek and Osman Babaarslan",authors:[{id:"119775",title:"Prof.",name:"Osman",middleName:null,surname:"Babaarslan",slug:"osman-babaarslan",fullName:"Osman Babaarslan"},{id:"175829",title:"Dr.",name:"Nazan",middleName:null,surname:"Kalebek",slug:"nazan-kalebek",fullName:"Nazan Kalebek"}]},{id:"41409",title:"Surface Modification Methods for Improving the Dyeability of Textile Fabrics",slug:"surface-modification-methods-for-improving-the-dyeability-of-textile-fabrics",totalDownloads:7038,totalCrossrefCites:13,totalDimensionsCites:36,abstract:null,book:{id:"3137",slug:"eco-friendly-textile-dyeing-and-finishing",title:"Eco-Friendly Textile Dyeing and Finishing",fullTitle:"Eco-Friendly Textile Dyeing and Finishing"},signatures:"Sheila Shahidi, Jakub Wiener and Mahmood Ghoranneviss",authors:[{id:"58854",title:"Dr.",name:null,middleName:null,surname:"Shahidi",slug:"shahidi",fullName:"Shahidi"}]},{id:"55424",title:"Textile Reinforced Structural Composites for Advanced Applications",slug:"textile-reinforced-structural-composites-for-advanced-applications",totalDownloads:3806,totalCrossrefCites:8,totalDimensionsCites:15,abstract:"Textile-reinforced composites are increasingly used in various industries such as aerospace, construction, automotive, medicine, and sports due to their distinctive advantages over traditional materials such as metals and ceramics. Fiber-reinforced composite materials are lightweight, stiff, and strong. They have good fatigue and impact resistance. Their directional and overall properties can be tailored to fulfill specific needs of different end uses by changing constituent material types and fabrication parameters such as fiber volume fraction and fiber architecture. A variety of fiber architectures can be obtained by using two- (2D) and three-dimensional (3D) fabric production techniques such as weaving, knitting, braiding, stitching, and nonwoven methods. Each fiber architecture/textile form results in a specific configuration of mechanical and performance properties of the resulting composites and determines the end-use possibilities and product range. This chapter highlights the constituent materials, fabric formation techniques, production methods, as well as application areas of textile-reinforced composites. Fiber and matrix materials used for the production of composite materials are outlined. Various textile production methods used for the formation of textile preforms are explained. Composite fabrication methods are introduced. Engineering properties of textile composites are reviewed with regard to specific application areas. The latest developments and future challenges for textile-reinforced composites are presented.",book:{id:"5921",slug:"textiles-for-advanced-applications",title:"Textiles for Advanced Applications",fullTitle:"Textiles for Advanced Applications"},signatures:"Nesrin Sahbaz Karaduman, Yekta Karaduman, Huseyin Ozdemir\nand Gokce Ozdemir",authors:[{id:"175839",title:"Ph.D.",name:"Nesrin",middleName:null,surname:"Sahbaz Karaduman",slug:"nesrin-sahbaz-karaduman",fullName:"Nesrin Sahbaz Karaduman"},{id:"201620",title:"Dr.",name:"Yekta",middleName:null,surname:"Karaduman",slug:"yekta-karaduman",fullName:"Yekta Karaduman"},{id:"201621",title:"Dr.",name:"Hüseyin",middleName:null,surname:"Özdemir",slug:"huseyin-ozdemir",fullName:"Hüseyin Özdemir"},{id:"201622",title:"Dr.",name:"Gökce",middleName:null,surname:"Özdemir",slug:"gokce-ozdemir",fullName:"Gökce Özdemir"}]}],onlineFirstChaptersFilter:{topicId:"1376",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],testimonialsList:[]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. The combination of electronics and computer science with biology and medicine has improved patient diagnosis, reduced rehabilitation time, and helped to facilitate a better quality of life. Nowadays, all medical imaging devices, medical instruments, or new laboratory techniques result from the cooperation of specialists in various fields. The series of Biomedical Engineering books covers such areas of knowledge as chemistry, physics, electronics, medicine, and biology. This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"June 25th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:8,paginationItems:[{id:"7",title:"Bioinformatics and Medical Informatics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",slug:"alexandros-tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",slug:"lulu-wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",slug:"hitoshi-tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",slug:"marcus-vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. His research interests include biomaterials, nanomaterials, bioengineering, biosensors, drug delivery systems, and tissue engineering.",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",slug:"cecilia-cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",slug:"gil-goncalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",slug:"johann-f.-osma",fullName:"Johann F. Osma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDv7QAG/Profile_Picture_1626602531691",institutionString:null,institution:{name:"Universidad de Los Andes",institutionURL:null,country:{name:"Colombia"}}},{id:"69697",title:"Dr.",name:"Mani T.",middleName:null,surname:"Valarmathi",slug:"mani-t.-valarmathi",fullName:"Mani T. Valarmathi",profilePictureURL:"https://mts.intechopen.com/storage/users/69697/images/system/69697.jpg",institutionString:"Religen Inc. | A Life Science Company, United States of America",institution:null},{id:"205081",title:"Dr.",name:"Marco",middleName:"Vinícius",surname:"Chaud",slug:"marco-chaud",fullName:"Marco Chaud",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSDGeQAO/Profile_Picture_1622624307737",institutionString:null,institution:{name:"Universidade de Sorocaba",institutionURL:null,country:{name:"Brazil"}}}]}]},overviewPageOFChapters:{paginationCount:45,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. Udoh, Josephine U. Agogbua, Eberechi R. Keyagha and Itorobong I. Nkanga",slug:"carotenoids-in-cassava-manihot-esculenta-crantz",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Carotenoids - New Perspectives and Application",coverURL:"https://cdn.intechopen.com/books/images_new/10836.jpg",subseries:{id:"13",title:"Plant Physiology"}}},{id:"82112",title:"Comparative Senescence and Lifespan",doi:"10.5772/intechopen.105137",signatures:"Hassan M. Heshmati",slug:"comparative-senescence-and-lifespan",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hassan M.",surname:"Heshmati"}],book:{title:"Mechanisms and Management of Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}}]},overviewPagePublishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"7264",title:"Calcium and Signal Transduction",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7264.jpg",slug:"calcium-and-signal-transduction",publishedDate:"October 24th 2018",editedByType:"Edited by",bookSignature:"John N. Buchholz and Erik J. Behringer",hash:"e373a3d1123dbd45fddf75d90e3e7c38",volumeInSeries:1,fullTitle:"Calcium and Signal Transduction",editors:[{id:"89438",title:"Dr.",name:"John N.",middleName:null,surname:"Buchholz",slug:"john-n.-buchholz",fullName:"John N. Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",biography:"Full Professor and Vice Chair, Division of Pharmacology, Loma Linda University, School of Medicine. He received his B.S. Degree in Biology at La Sierra University, Riverside California (1980) and a PhD in Pharmacology from Loma Linda University School of Medicine (1988). Post-Doctoral Fellow at University of California, Irvine, College of Medicine 1989-1992 with a focus on autonomic nerve function in blood vessels and the impact of aging on the function of these nerves and overall blood vessel function. Twenty years of research funding and served on NIH R01 review panels, Editor-In-Chief of Edorium Journal of Aging Research. Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",institutionURL:null,country:{name:"Hungary"}}}]},{type:"book",id:"8008",title:"Antioxidants",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/8008.jpg",slug:"antioxidants",publishedDate:"November 6th 2019",editedByType:"Edited by",bookSignature:"Emad Shalaby",hash:"76361b4061e830906267933c1c670027",volumeInSeries:5,fullTitle:"Antioxidants",editors:[{id:"63600",title:"Prof.",name:"Emad",middleName:null,surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby",profilePictureURL:"https://mts.intechopen.com/storage/users/63600/images/system/63600.png",biography:"Dr. Emad Shalaby is a professor of biochemistry on the Biochemistry Department Faculty of Agriculture, Cairo University. He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. He is a member of seven international specialized scientific societies, besides his local one, and\nhe has won seven prizes.",institutionString:"Cairo University",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}]}]},openForSubmissionBooks:{paginationCount:6,paginationItems:[{id:"11669",title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",hash:"9117bd12dc904ced43404e3383b6591a",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 3rd 2022",isOpenForSubmission:!0,editors:[{id:"415310",title:"Assistant Prof.",name:"Erik",surname:"Froyen",slug:"erik-froyen",fullName:"Erik Froyen"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11672",title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",hash:"c00855833476a514d37abf7c846e16e9",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 6th 2022",isOpenForSubmission:!0,editors:[{id:"14794",title:"Prof.",name:"Murat",surname:"Şentürk",slug:"murat-senturk",fullName:"Murat Şentürk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11674",title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",hash:"5d7d49bd80f53dad3761f78de4a862c6",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 6th 2022",isOpenForSubmission:!0,editors:[{id:"238047",title:"Dr.",name:"Gaia",surname:"Favero",slug:"gaia-favero",fullName:"Gaia Favero"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11670",title:"Chitin-Chitosan - Isolation, Properties, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11670.jpg",hash:"69f009be08998711eecfb200adc7deca",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 26th 2022",isOpenForSubmission:!0,editors:[{id:"176093",title:"Dr.",name:"Brajesh",surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"12215",title:"Cell Death and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/12215.jpg",hash:"dfd456a29478fccf4ebd3294137eb1e3",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"June 24th 2022",isOpenForSubmission:!0,editors:[{id:"59529",title:"Dr.",name:"Ke",surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11673",title:"Stem Cell Research",coverURL:"https://cdn.intechopen.com/books/images_new/11673.jpg",hash:"13092df328080c762dd9157be18ca38c",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"203598",title:"Ph.D.",name:"Diana",surname:"Kitala",slug:"diana-kitala",fullName:"Diana Kitala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",institutionString:"Université Laval",institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Business and Management",value:86,count:1}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1}],authors:{}},subseries:{item:{id:"10",type:"subseries",title:"Animal Physiology",keywords:"Physiology, Comparative, Evolution, Biomolecules, Organ, Homeostasis, Anatomy, Pathology, Medical, Cell Division, Cell Signaling, Cell Growth, Cell Metabolism, Endocrine, Neuroscience, Cardiovascular, Development, Aging, Development",scope:"Physiology, the scientific study of functions and mechanisms of living systems, is an essential area of research in its own right, but also in relation to medicine and health sciences. The scope of this topic will range from molecular, biochemical, cellular, and physiological processes in all animal species. Work pertaining to the whole organism, organ systems, individual organs and tissues, cells, and biomolecules will be included. Medical, animal, cell, and comparative physiology and allied fields such as anatomy, histology, and pathology with physiology links will be covered in this topic. Physiology research may be linked to development, aging, environment, regular and pathological processes, adaptation and evolution, exercise, or several other factors affecting, or involved with, animal physiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",hasOnlineFirst:!1,hasPublishedBooks:!1,annualVolume:11406,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"306970",title:"Mr.",name:"Amin",middleName:null,surname:"Tamadon",slug:"amin-tamadon",fullName:"Amin Tamadon",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002oHR5wQAG/Profile_Picture_1623910304139",institutionString:null,institution:{name:"Bushehr University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",institutionString:null,institution:{name:"Alexandria University",institutionURL:null,country:{name:"Egypt"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",institutionString:"Kafkas University",institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}}]},onlineFirstChapters:{},publishedBooks:{paginationCount:4,paginationItems:[{type:"book",id:"9528",title:"Current Topics and Emerging Issues in Malaria Elimination",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9528.jpg",slug:"current-topics-and-emerging-issues-in-malaria-elimination",publishedDate:"July 21st 2021",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"7f178329cc42e691efe226b32f14e2ea",volumeInSeries:8,fullTitle:"Current Topics and Emerging Issues in Malaria Elimination",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7981",title:"Overview on Echinococcosis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7981.jpg",slug:"overview-on-echinococcosis",publishedDate:"April 22nd 2020",editedByType:"Edited by",bookSignature:"Fethi Derbel and Meriem Braiki",hash:"24dee9209f3fd6b7cd28f042da0076f0",volumeInSeries:6,fullTitle:"Overview on Echinococcosis",editors:[{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",institutionString:"Clinique les Oliviers",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/298608",hash:"",query:{},params:{id:"298608"},fullPath:"/profiles/298608",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()