The main characteristics of the three types of gasifiers commonly used for the recovery of heat and electricity from biomass [7].
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\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
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\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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In native herbal medicine, a leaf or bark decoction or tincture from mulungu has long been used in folk medicine due to their tranquilizing effects and as natural sedative. It is also anxiolytic and antibacterial (Garín-Aguilar et al., 2000). In both Brazil and Peru mulungu is used for epilepsy (Vasconcelos et al., 2007). Practitioners in the United States use mulungu to quiet hysteria from trauma or shock, as a mild sedative to calm the nervous system, to treat insomnia and promote healthy sleeping patterns. Anxiety disorders are among the most prevalent psychiatric diseases and mulungu offers novel therapy chance (Balbani et al., 2009; Patocka, 2009). Latest the present results suggest that
Pharmacological assays performed with the alkaloids of
People\'s healers and some practitioners in The United States use mulungu to quiet hysteria from trauma or shock, as a mild, hypnotic sedative to calm the nervous system, to treat insomnia and promote healthy sleeping patterns, to regulate heart palpitations, and to treat hepatitis and liver disorders. Nevertheless, despite its wide popular utilization, the supposed therapeutic properties of
The chemicals constituents of mulungu have been studied extensively after modern medical science find health potential of this biomedicine. In this biological material have been found large amounts of novel flavonoids, triterpenes, and alkaloids (Da-Cunha et al., 1996; Majinda et al., 2005; Cui et al., 2009). The genus
The most considerable group of biologicaly active compounds of mulungu are alkaloids (Ozawa et al. 2009). The alkaloids have been found in 78 of 107 species in the genus
The pivotal structure of erythrinan alkaloids is tetraheterocyclic nitrogen compound with tetrahydroisoquinoline moiety called erythrinane (I) (Amer et al., 1991). Compounds of these structure were known for a long time (Koniuszy et al., 1949), but until medical science research of mulungu ignified concern over these alkaloids. Heft of erythrinan alkaloids are derivatives of I substituted at nucleus A and D by hydroxyl or alkoxy groups. The most considerable erythrinan alkaloids are erysotrine (II), erythravine (III), erysodine (IV), and erysopine (V) (Fig. 1) (Flausino et al., 2007a,b). For ever new erythrinan alkaloids are recovered (Tanaka et al., 2008; Cui et al., 2009, Parsons and Palframan, 2010).
Chemical structures of erythrinan alkaloids. Erythrinan alkaloids are derived from tetraheterocyclic nitrogen compound with tetrahydroisoquinoline moiety called erythrinane (I). Heft of erythrinan alkaloids are derivatives of I substituted at nucleus A and D by hydroxyl or alkoxy groups. The most considerable erythrinan alkaloids are erysotrine (II), erythravine (III), erysodine (IV), and erysopine (V).
Mulungu is relatively safe remedy. Acute oral toxicity (LD50) of aqueous extract of stem bark of
The toxicity of chloroform stem bark extract of
Mulungu is less toxic than most of synthetic tranquilizers, e.g. LD50 value for diazepam in mice at peroral administration is 49 mg/kg (Hogskilde et al., 1987). To evaluate the acute toxicity of the aqueous extract of
The traditional use of mulungu for anxiety and stress has been validated by researchers in a few studies, where it was shown to alter anxiety-related responses (Flausino et al. 2007a,b). An animal model (correlating to human generalized anxiety disorder, as well as panic disorder) was undertaken on a water-alcohol extract of mulungu (Vasconcelos et al. 2004; Ribeiro et al. 2006; Flausino et al. 2007a). Vasconcelos and co-workers (2004) studied the effects of hydroalcoholic extracts of both
The researchers reported that the mulungu extract had an effect similar to the commonly-prescribed anti-anxiety drug diazepam (Onusic et al. 2003; Ribeiro et al. 2006; Teixeira-Silva et al. 2008). Raupp and co-workers (2008) administered orally the hydroalcoholic extract of the stem bark of
It was suggested in many studies that the alkaloids in
Hydroalcoholic extracts from the stem bark of
Further research has validated the traditional use of mulungu as an antimicrobial agent for throat and urinary infections. Mulungu has demonstrated antibacterial activity against
Two new compounds with antibacterial effect, erybacin A and erybacin B, were isolated from the roots of
Hydroalcoholic extracts from the stem bark and leaves of
Alkaloid erysodine is a competitive antagonist at neuronal nicotinic acetylcholine receptors (Mansbach et al., 2000). The potent and competitive nature of erysodine\'s antagonism together with its ability to enter the brain after systemic administration suggest that erysodine may be a useful tool in characterizing neuronal nicotinic acetylcholine receptors (Decker et al., 1995). Recent findings show that erysodine and also dihydro-beta-erythroidine are potent and selective competitive inhibitors of alpha4beta2 nicotinic acetylcholine receptors (Iturriaga-Vásquez et al., 2010).
Erythrinan alkaloids cristanine A and cristanine B were isolated from the bark of
Mulungu, drug from the tree
The use of herbal medicines by physicians in Europe, Asia, and America, exploring their traditional remedies to find a suitable cure of these ‘mind affecting diseases’ and herbal medicines are often considered to be gentle and safe alternative to synthetic drugs. Nevertheless, till this time no relevant clinical study exist.
Recently many studies of other
From the bark of
Two new dimethylpyrano-isoflavones, named erymildbaedin A and B, were isolated from the stem bark of
Another flavonoids with the antibacterial activity were isolated from
Evidence suggests that conventional energy production has limited capacity to meet growing demand and that additional demands will have to be met by unorthodox sources. Since the world is now drifting toward sustainable development, renewable energy technologies are gaining traction. One of such renewable energy technologies that has received great attention in recent times include biomass gasification, which is one of three main (combustion and pyrolysis) thermochemical conversion pathways used to recover energy from biomass materials. Gasification produces energy from biomass and involves heating the biomass at elevated temperatures (above 1000°C) under a limited supply of oxygen to produce a mixture of gases (H2, CO, CO2) collectively referred to as syngas. However, the combustible constituents of the syngas are CO and H2 and can be used as fuel in gas engines for heat and electricity generation as well as for the production of chemicals (such as alcohols, organic acids, ammonia, and methanol) via the Fischer-Tropsch process [1]. The significance of gasification technology is such that it helps waste management, at the same time, produces energy and other valuable products needed for economic growth. Systems designed to gasify coal is assumed to be able to use biomass as well, however, differences in the characteristics of coal and biomass can have a significant impact on the sizing and design of the combustion chamber of the gasification system, as well as on the location of the gasifying agent [2]. A graphical representation of a gasification process, which depicts feedstock flexibility and the production of a wide range of products, is presented in Figure 1.
A schematic representation of a gasification process depicting feedstock flexibility and the wide range of products that can be obtained from the process [
The gasification technology has existed for several decades and has, as of today, been commercialized in very few countries of the world like Sweden, Germany, Canada, the United States, India, and China. The use of this technology offers a number of ecological and economic advantages such as low emission of pollutants, reduction in the environmental effects of waste disposal, generation of non-hazardous by-products when biomass is used as the feedstock, and lower operating cost [4].
Gasification occurs in a gasifier under a series of chemical reactions that are mostly endothermic in nature; however, to provide the heat required for the reactions to proceed successfully, and the heat needed for drying and pyrolysis to occur, a certain amount of exothermic combustion is allowed in the gasifier [4, 5]. The gasification reactions are described in greater detail in subsequent sections. The gasifier and its configuration are key factors that affect the entire gasification process, including the reactions occurring and their products [6]. This is true because gasifiers are generally classified into three broad groups, namely: the fixed bed gasifiers, the fluidized bed gasifiers, and the entrained flow gasifiers. Table 1 shows the main characteristics of these three gasifiers.
Type of gasifier | Characteristics |
---|---|
The fixed beds |
|
The fluidized beds |
|
The entrained flows |
|
The main characteristics of the three types of gasifiers commonly used for the recovery of heat and electricity from biomass [7].
Although the gasification technology may be considered as a useful technology for the recovery of energy from biomass materials, the technological choices with regards to the type of gasification system (fixed bed, fluidized beds, or entrained flow reactors) for the conversion of biomass are still faced with a host of technical barriers that have hindered the significant exploitation of the gasification technology and biomass energy as a whole. The quality of the syngas produced from the gasification process, the lack of feedstock flexibility and its mechanism of conversion are the main obstacles. This chapter, therefore, presents an overview of the gasification technology and discusses its main technical barriers with reference to the gasification systems commonly used today. The status of current research in gasification and future research focus are also presented.
There are different types of gasification systems but the most commonly used are the fixed-bed, fluidized-bed, and entrained-flow gasification systems. The main differences between these gasifiers are connected to their mechanism of heating and the way feedstock and gasifying agents are introduced in the gasification process, as well as by the location of syngas output [8, 9, 10]. However, the technological choices toward these gasifiers are guided by the nature and availability of biomass feedstocks. While the characteristics of biomass feedstocks intended for gasification are detailed in [11], the principles of operation of the types of gasifiers mentioned above and their merits and demerits are equally well described in [12, 13] and in [14]. These gasification systems may appear as simple devices but their successful operations are not so simple. The gasifiers are still faced with a host of technical issues that have hindered their broader market penetration. These technological barriers are described in Section 5. Nonetheless, in order to fully comprehend the technical barriers of each of these gasifiers, it is important to understand the differences between the gasifiers in terms of configuration, which also affects the thermodynamics of their operation. Therefore, a schematic diagram of each gasifier type is presented in Figure 2.
Schematic representations of the gasification systems in use today: (a) fixed bed; (b) fluidized bed; (c) entrained flow. Reproduced with permission from [
The key mechanism of the gasification technology involves the conversion of solid carbonaceous materials like biomass into flammable gas by partial oxidation. However, the chemistry involved in the process is quite complex and can be achieved via a series of physical and chemical transformation reactions that occur inside the gasification system [4, 16]. The major chemical reactions occurring are those that involve the degradation of large organic molecules into carbon monoxide (CO), carbon dioxide (CO2), hydrogen (H2), water in the form of steam (H2O), and methane (CH4). These reactions take place in accordance with the chemical bonding theory and can be represented thus [3]:
The combustion reactions include:
Other key gasification reactions are:
The above reactions occur under standard operating conditions of gasification and are considered important reactions that form the major part of the syngas produced in the gasification process [4, 16]. While reaction (4) may be referred to as the “Water-Gas Reaction”, reactions (5) and (6) are termed the “Boudouard Reaction” and the “Methanation Reaction” respectively. Reactions (4) and (5) are the main reduction reactions. However, under high carbon conversion conditions, reactions (4)–(6), being heterogeneous in nature, are reduced to the following homogeneous gas-phase reactions [16]:
Reactions (7) and (8) are known respectively as the “Water-Gas-Shift Reaction” and the “Steam-Methane-Reforming Reaction”. These two reactions (7) and (8) play a key role in determining the final equilibrium of the composition of the syngas produced in the gasification process [3, 16]. Under a limited supply of oxygen to the gasifier, the sulfur composition of the feedstock is converted to hydrogen sulfide (H2S), with a minute amount forming carbonyl sulfide (COS). The nitrogen (N) chemically bound in the feedstock is converted to gaseous nitrogen (N2), ammonia (NH3), and traces of hydrogen cyanide (HCN). The chlorine in the feedstock is mainly converted to hydrogen chloride (HCl). It is important to however state that the concentrations of sulfur, nitrogen and chloride in the feedstock for gasification are sufficiently low that their effects in the gasification process are quite insignificant; trace elements (such as arsenic, mercury, and other heavy metals) that are associated with both the organic and inorganic components of the feedstock are mostly contained in the fractions of ash and slag formed during gasification, as well as in the gases emitted, and must be expunged from the syngas prior to further use [16].
Temperature increases in a gasification process lead to dehydration, volatilization, and degradation of the biomass feedstock. The gasification process reactions are mostly reversible reactions. The order of the reactions and their conversion rates are often subject to the limitations of the reaction kinetics and thermodynamic equilibrium of the gasification process. For instance, reactions (1)–(3) presented in a previous section are combustion reactions that actually go to completion when equilibrium positions of the reactions shift to the right. However, not all reactants in a gasification process can be completely converted into products; as such, stoichiometric calculations may be required to determine the products of a completed reaction [5].
While the kinetics of a reaction can determine how fast products are formed and whether the reactions in the gasifier go to completion, the equilibrium state of the reaction determines to what extent the reaction can progress. The thermal efficiency of the gasification process and the composition of the syngas produced are strongly influenced by the thermodynamic equilibrium of the water-gas-shift reaction and the steam-methane-reforming reaction (reactions (7) and (8), Section 3) [3, 4]. A useful tool for evaluating important design parameters of a gasification technology is thermodynamic modeling. With this tool, process efficiency can be optimized at different operating conditions; the relative quantities of gasifying agents such as oxygen and steam can also be calculated including the composition of the product syngas.
An understanding of the technical challenges of gasification technology requires a basic understanding of the factors that control the stability of gasifier operation. A typical gasification process includes the following four key steps: drying, pyrolysis, oxidation, and reduction. There are no strict boundaries between these steps; they often overlap and a host of factors including the type of gasifier, feedstock type, and process parameters, such as temperature, determines the output of a gasification process involving the four key steps listed above [4, 5, 8]. The operating temperature of a gasification process is a function of the amount of oxygen fed to the gasification system (gasifier), which induces partial gasification. Temperature response will abruptly change at an equivalence ratio (ER) of about 0.25; depending on the source of oxygen, this change point is typical of gasifier temperatures in the range 600–800°C; some quantities of oil and tar are produced in the pyrolysis stage of the gasification process. These products of the pyrolysis stage are stable for about a second at temperatures lower than 600°C [13].
The fixed bed updraft gasifier operates at temperatures below 600°C and generates considerable amounts of tars that are often emitted with the syngas, while its counterpart, the downdraft gasifier (also of the fixed bed type) is self-regulating and produces far less tar relative to the updraft gasifier; the fluidized bed gasifier also has high tar production rate, in fact, its tar production rate is greater than other types of gasifiers like the fixed bed and the entrained flow gasifiers [13, 14, 17].
Although the gasification technology has experienced development over several decades and has been commercialized in a number of countries like those previously mentioned [14]; its successful operation is not as simple as can be imagined because of the thermodynamics of the operation of the technology are not well understood. Further exploitation of the technology still needs to overcome a considerable number of technical issues. A description of the technological barriers that are associated with each type of gasification technology is presented thus:
The fixed bed gasifiers (updraft, downdraft, and crossdraft) are the simplest of all the types of gasifiers and are mainly suitable for small-scale applications (<10 MWth) [5]. Although they (fixed bed gasifiers) are very advantageous in terms of their simplicity and ease of operation, they generally suffer from poor mixing and poor heat transfer within the gasifier, which makes it difficult to achieve even distribution of fuel and temperature across gasifier geometry hence scale-up of this type of gasifier is difficult. The fixed bed downdraft gasifier, which has not satisfactorily performed with feedstock capacity beyond 425 kg/h [18], is a typical example of the described technical issue. This is because air cannot travel up the center of the gasifier, which creates cold spots in and around the combustion zone of the gasifier during operation and results in reduced gasification efficiency. This limitation has been attributed to design characteristics in terms of gasifier geometry (throat angle and throat diameter) and air inlet velocity. In the case of the updraft gasifier however, its high tar production rate (5–20%) [19] remains a challenge to date and renders this type of gasifier unsuitable where a clean product gas (syngas) is desired. Due to its high tar production rate, the updraft gasifier is well-suited for the gasification of low-volatile feedstocks like charcoal [5].
In terms of configuration, the fluidized bed gasifier (FBG) operates on the principle of fluidization where a gas stream is forced through a particle bed vessel that behaves like a fluid under certain conditions such as high particle flow velocity. The commonly used fluidization media include air, steam, or mixtures of steam/oxygen. The FBG is the most efficient of all types of gasifiers and its efficiency is mainly dependent upon the thermochemical and fluid behavior inside the gasifier; this type of gasifier is more appropriate for medium-scale units of about 5–100 MWth [5, 20, 21]. From a system performance and technical point of view, the operation of the FBG is quite complex because of the need to simultaneously control air supply, bed material, and feedstock during operation of the gasifier. As a result, the product gas obtained from the gasification process may be very high in particulates, which can circulate and cause equipment erosion. Although it may sway the gasification process, the FBG is operated at high-pressure conditions, which can result in low volumetric gas flow rates, condensation during compression, and other operational complications such as defluidization from particle agglomeration particularly when agricultural crops and wastes are used as feedstock in the gasification process. This is because agricultural crops and wastes contain an increased amount of ash/alkali and, the alkali content of ash (such as sodium and potassium alkali) can form low-melting eutectics with the silica in the sand, which is the regularly used bed material in FBG processes [22]. Under this condition, agglomeration and sintering will occur, triggering the formation of a thin sticky substance around the bed particles with an instant loss of bed fluidization (defluidization). Typical factors influencing agglomeration and the loss of fluidization in FBGs are presented in Table 2.
Parameter | Agglomeration and loss of fluidization (defluidization) |
Temperature | The possibilities of agglomeration and defluidization are exacerbated by rising temperatures. |
Steam | Agglomeration and defluidization can occur upon increase in steam during gasification due to the formation of molten sodium disilicate, which can occur via liquid-solid reaction under steam application conditions. |
Alkalis, iron sulfides, and siderite | Increases the possibilities of the formation of sticky substances, which can, in turn, facilitate agglomeration and defluidization. |
Fluidization velocity | The tendencies of agglomeration are lowered below the sintering temperature of ash when the velocity of fluidization is increased. The force of segregation also increases under this circumstance. |
Particle size distribution | The possibilities of agglomeration and defluidization are high when bimodal or multimodal particle size distribution occurs. |
Even if more sophisticated bed materials such as alumina and magnesite are used in the FBG process of feedstocks with high ash/alkali content, process cost will become an issue of concern. These types of technical issues call to question the feedstock flexibility of the FBG systems.
The entrained flow gasifier (EFG) is an old alternative energy production technology used on a large-scale (>50 MWth) [5] in the petroleum industry for the gasification of petroleum residues. This type of gasifier offers greater rates of collision between solid particles and is considered excellent in terms of performance because of vigorous mixing of feedstock and oxidizing agent as well as better feed conversion efficiencies in comparison to other types of gasifiers [25]. However, even though the EFG has been in existence for centuries, it has not been exploited to its full potential partly because the fundamental principles underpinning its operation are still vague, particularly with regards to the type of material suitable as feedstock. The mechanisms involved in the feedstock conversion process are still under debate. In addition, the EFG is operated at very high temperatures (1,200 – 2,000°C) and pressures, under these operating conditions, fuel-oxygen mixtures are turned into a turbulent flame of dust that ensures the production of liquid ash, which are deposited on gasifier walls. This constitutes a technical issue of concern, particularly when analyzing the ash melting behavior of the material used as feedstock in the gasification process. Due to this high operating pressure, numerical modeling and experimental validation of the EFG tend to be onerous. Furthermore, due to its operating conditions, only specific types of materials are used as feedstock.
Extensive studies have been undertaken on gasification technology over the last decade. Despite the numerous studies, however, there are still pending research-related issues (such as those described in preceding sections) that require further improvements. For example, Kaushal et al. [26] developed a one-dimensional steady-state model specific to the bubbling fluidized bed gasifier (BFBG). Gómez-Barea et al. [27] also reviewed the performance optimization of a small-scale FBG plant with the aim of maximizing char conversion rate and minimizing secondary gas treatments. The process performance of the downdraft gasifier was evaluated by Biagini et al. [28] in which the performance parameters such as syngas production, syngas heating value, cold gas efficiency, and the net efficiency of the gasifier were monitored using corn cobs as feedstock. Furthermore, the performance of a pilot-scale pressurized entrained-flow (EFG) plant using stem wood made from pine and spruce as feedstocks was assessed by Weiland et al. [29]. A combined system involving gasification, hydrothermal carbonization (HTC), and solid oxide fuel cell (SOFC) technologies was developed by Papa et al. [30] using commercial process simulation software (ASPEN Plus), where the focus was to investigate the efficiency of the system under various operating conditions. The challenges and opportunities of modeling the gasification technology using Aspen Plus were also detailed by Mutlu and Zeng who alluded to the issues of the gasification technology as hindering the widespread commercialization of the technology [31].
The FBGs such as the downdraft gasifier is characterized by four distinct reaction zones including the drying, pyrolysis, combustion, and reduction zones respectively; the specific functions of each of these zones are described in [32]. Of these distinct reaction zones, the combustion zone, also known as the oxidation zone, is considered the most important zone because heat is generated in this zone. However, the presence of cold spots (a factor linked to uneven heat distribution in and around the combustion zone of the downdraft gasifier), is the main reason why these types of gasifiers are limited to small-scale applications [13]. There are basically two methods that can provide a solution to the problem of uneven heat distribution in fixed bed systems: one method is to decrease the cross-sectional area of the gasifier at a certain height. This means altering the design characteristics of the throat angle and throat diameter of the gasifier by way of size-reduction. The other method is to centralize the air inlet and its velocity using nozzles that are positioned in a way that allows the throat circumference of the gasifier to be captured.
In the case of the FBGs, although a well-established technology (in terms of design concept) for heat and power generation, bed defluidization, as indicated in a previous section, is considered the main technical issue, which as previously described, occurs due to agglomeration and pressure drops, particularly when gasifying feedstocks with high amounts of ash such as agricultural residues and wastes. Alkali silicates such as calcium, potassium, and sodium silicates present in ash can form low-melting eutectics with silica, which is often used as the bed material in FBGs [22]. A quick and easy solution to the defluidization problems in FBGs is to replace the commonly used bed material (silica) with more advanced artificial materials such as aluminum oxide or magnesium carbonate. However, the cost associated with the use of these materials may constitute a major drawback. Therefore, the hydrodynamics of the FBG needs to be further investigated and the hydrodynamic study must incorporate devolatilization kinetics, char gasification, and gas species in relation to particle agglomeration and sintering.
For the high-pressure EFG, the production of molten ash (which mostly originates from the ash constituents of the feedstock and forms deposits on the walls of the gasifier) is a commonly encountered technical problem. Depending on the operating conditions of the gasification process, the molten ash deposits often solidify, causing plugging and the blockage of critical parts of the gasifier thereby hindering process efficiency. Therefore, just like the FBG, a solution to the problem of molten ash formation in the EFG is to further investigate the feedstock conversion mechanism and gasifier hydrodynamics, particularly when more complex low-grade feedstocks such as agricultural residues and biomass-based chars are used in the gasification process under high-pressure conditions.
Studies [33, 34] have shown that modeling work has accelerated the research progress made in the field of biomass gasification since gasifier design and operating conditions can be optimized at minimal time and costs. However, modeling and simulation cannot replace good experimental investigations. In fact, studies [35] have determined that mathematical modeling and simulation of high temperature and pressure reaction systems involving gaseous, liquid, and solid phases is a major scientific challenge. Therefore, addressing the technical issues of the gasification technologies described in this chapter will not only require the development of a robust and sophisticated model that can be applied to a wider range of operating parameters of the gasifiers but also able to replicate actual operations of the gasification technologies with an acceptable level of anomaly.
Gasifier design and process optimization for complex biomass feedstocks, in general, are very challenging due to the lack of detailed understanding of the various thermochemical reaction steps governing the conversion of biomass feedstocks under high temperature and pressure conditions. The gasification technologies described in this chapter are multiphase systems that are characterized by complex operational steps. Therefore, in order to better comprehend the complex interactions between process steps during gasification and to address the technological issues earlier described, experimental studies under systematic variation of feed specification and process parameters are required. It is also necessary to ensure proper process mapping based on experimental data from lab- to pilot-scale in order to develop a comprehensive gasification process understanding and to provide a thorough data basis for the validation of numerical simulations. This implies the development of state-of-the-art experimental techniques that are applicable under the acrid conditions of gasification technologies.
The authors declare no conflict of interest.
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\\n\\nBut, one thing we have in common is -- we are all scientists at heart!
\\n\\nSara Uhac, COO
\\n\\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
\\n\\nAdrian Assad De Marco
\\n\\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\\n\\nDr Alex Lazinica
\\n\\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
\\n"}]'},components:[{type:"htmlEditorComponent",content:"Our business values are based on those any scientist applies to their research. We have created a culture of respect and collaboration within a relaxed, friendly and progressive atmosphere, while maintaining academic rigour.
\n\nCo-founded by Alex Lazinica and Vedran Kordic: “We are passionate about the advancement of science. As Ph.D. researchers in Vienna, we found it difficult to access the scholarly research we needed. We created IntechOpen with the specific aim of putting the academic needs of the global research community before the business interests of publishers. Our Team is now a global one and includes highly-renowned scientists and publishers, as well as experts in disseminating your research.”
\n\nBut, one thing we have in common is -- we are all scientists at heart!
\n\nSara Uhac, COO
\n\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
\n\nAdrian Assad De Marco
\n\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\n\nDr Alex Lazinica
\n\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. 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Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/288903",hash:"",query:{},params:{id:"288903"},fullPath:"/profiles/288903",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()