\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"10637",leadTitle:null,fullTitle:"Functional Foods - Phytochemicals and Health Promoting Potential",title:"Functional Foods",subtitle:"Phytochemicals and Health Promoting Potential",reviewType:"peer-reviewed",abstract:"The phytochemicals present in functional foods play a vital role in boosting immunity and promoting health. This book provides a comprehensive overview of the importance of functional foods and antioxidants and their scavenging activity for preventing various health-related disorders. This book also covers the therapeutic and medicinal potential of various bioactive compounds for a healthy lifestyle, as well as examines different products containing functional ingredients that demonstrate health-promoting potential.",isbn:"978-1-83968-933-8",printIsbn:"978-1-83968-932-1",pdfIsbn:"978-1-83968-934-5",doi:"10.5772/intechopen.93962",price:139,priceEur:155,priceUsd:179,slug:"functional-foods-phytochemicals-and-health-promoting-potential",numberOfPages:432,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"a4aa0abf066e78deed1f65312ff24b22",bookSignature:"Muhammad Sajid Arshad and Muhammad Haseeb Ahmad",publishedDate:"November 10th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10637.jpg",numberOfDownloads:5465,numberOfWosCitations:1,numberOfCrossrefCitations:5,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:11,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:17,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 29th 2020",dateEndSecondStepPublish:"October 27th 2020",dateEndThirdStepPublish:"December 26th 2020",dateEndFourthStepPublish:"March 16th 2021",dateEndFifthStepPublish:"May 15th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"192998",title:"Dr.",name:"Muhammad Sajid",middleName:null,surname:"Arshad",slug:"muhammad-sajid-arshad",fullName:"Muhammad Sajid Arshad",profilePictureURL:"https://mts.intechopen.com/storage/users/192998/images/system/192998.jpg",biography:"Dr. Muhammad Sajid Arshad is currently working as Assistant Professor at Department of Food Science, Government College University Faisalabad, Pakistan. He served as visiting research scholar at the University of Illinois, Urbana Champaign, the USA for a period of six months. He received his doctoral degree from the University of Agriculture, Faisalabad, Pakistan in 2013. From 2016-2017, he worked as postdoctoral fellow at Kyungpook National University, South Korea for one year. He worked with Iowa State University, the USA for 3 weeks. Later on, he got training from the University of Melbourne, Australia for 2 weeks. Dr. Arshad is author of about 65 publications and 10 book chapters to his credit. He has presented his papers in different national and international conferences in USA, Canada, Australia, South Korea, Thailand, and Turkey. He received several national and international awards in his field. His area of research is food science particularly functional foods, non-thermal processing technologies, muscle foods, and halal foods.",institutionString:"Government College University, Faisalabad",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"292145",title:"Dr.",name:"Muhammad",middleName:null,surname:"Haseeb Ahmad",slug:"muhammad-haseeb-ahmad",fullName:"Muhammad Haseeb Ahmad",profilePictureURL:"https://mts.intechopen.com/storage/users/292145/images/system/292145.png",biography:"Dr. Muhammad Haseeb Ahmad is currently an assistant professor in the Department of Food Science, Government College University Faisalabad, Pakistan. He also served as an assistant professor for one year at the National Institute of Food Science and Technology, University of Agriculture Faisalabad, Pakistan. He received his doctoral degree from Hohenheim University, Stuttgart, Germany, in 2016. During his stay there, he also worked as a research associate for research projects relevant to various food disciplines. Dr. Ahmad is the author of about thirty five research publications and twelve book chapters. He has also presented his research work at various national and international conferences (25). His area of research is food science with special expertise in process analytics and data mining.",institutionString:"Government College University, Faisalabad",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"323",title:"Food and Nutrition",slug:"food-and-nutrition"}],chapters:[{id:"78318",title:"Functional Foods and Human Health: An Overview",doi:"10.5772/intechopen.99000",slug:"functional-foods-and-human-health-an-overview",totalDownloads:527,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Functional food is a whole ingredient or a part of food that used as food for specific therapeutic purposes. It is divided into two wide categories: Conventional and modified functional foods. Conventional functional Foods are composed of natural or whole-food ingredients that provide functional substances while modified functional is food or food products in which add additional ingredients for specific health purposes. Plant-based food such as fruits, vegetables, herbs, cereals, nuts and beans contain vitamins, minerals, fiber, omega-3 fatty acids, antioxidants and phenolic compounds that play a functional role in the human body against chronic diseases including cancer, cardiovascular and GIT-related disease. Some other foods or food products like juices, dairy products, fortified eggs and seafood are composed of functional components. Fish contain omega-3 fatty acids (EPA and DHA) that are played a functional role in heart health and brain development.",signatures:"Muhammad Sajid Arshad, Waseem Khalid, Rabia Shabir Ahmad, Muhammad Kamran Khan, Muhammad Haseeb Ahmad, Saira Safdar, Safura Kousar, Haroon Munir, Umair Shabbir, Muhammad Zafarullah, Muhammad Nadeem, Zubia Asghar and Hafiz Ansar Rasul Suleria",downloadPdfUrl:"/chapter/pdf-download/78318",previewPdfUrl:"/chapter/pdf-preview/78318",authors:[{id:"192998",title:"Dr.",name:"Muhammad Sajid",surname:"Arshad",slug:"muhammad-sajid-arshad",fullName:"Muhammad Sajid Arshad"},{id:"416870",title:"Dr.",name:"Muhammad Haseeb",surname:"Ahmad",slug:"muhammad-haseeb-ahmad",fullName:"Muhammad Haseeb Ahmad"},{id:"416871",title:"Dr.",name:"Muhammad Kamran",surname:"Khan",slug:"muhammad-kamran-khan",fullName:"Muhammad Kamran Khan"},{id:"416872",title:"Mr.",name:"Waseem",surname:"Khalid",slug:"waseem-khalid",fullName:"Waseem Khalid"},{id:"416873",title:"Ms.",name:"Zubia",surname:"Asghar",slug:"zubia-asghar",fullName:"Zubia Asghar"},{id:"416874",title:"Ms.",name:"Saira",surname:"Safdar",slug:"saira-safdar",fullName:"Saira Safdar"},{id:"416875",title:"Ms.",name:"Safura",surname:"Kousar",slug:"safura-kousar",fullName:"Safura Kousar"},{id:"416876",title:"Dr.",name:"Rabia Shabir",surname:"Ahmad",slug:"rabia-shabir-ahmad",fullName:"Rabia Shabir Ahmad"},{id:"416877",title:"Dr.",name:"Muhammad",surname:"Nadeem",slug:"muhammad-nadeem",fullName:"Muhammad Nadeem"},{id:"416879",title:"Dr.",name:"Muhammad",surname:"Zafarullah",slug:"muhammad-zafarullah",fullName:"Muhammad Zafarullah"},{id:"416880",title:"Dr.",name:"Umair",surname:"Shabbir",slug:"umair-shabbir",fullName:"Umair Shabbir"},{id:"416881",title:"Dr.",name:"Haroon",surname:"Munir",slug:"haroon-munir",fullName:"Haroon Munir"},{id:"417013",title:"Dr.",name:"Hafiz Ansar Rasul",surname:"Suleria",slug:"hafiz-ansar-rasul-suleria",fullName:"Hafiz Ansar Rasul Suleria"}],corrections:null},{id:"75459",title:"Why Produce Food-Bioactive Compounds to Generate Functional Grade Foods?",doi:"10.5772/intechopen.96421",slug:"why-produce-food-bioactive-compounds-to-generate-functional-grade-foods-",totalDownloads:221,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Functional foods are those with health benefits but cannot incorporate and protect from oxidation or deterioration, maintaining the bioactive compounds (BC) activity. The liposomes have several advantages for BC encapsulation: ease of obtention, characterization, scaling-up, lipid protection for hydrophilic and lipophilic BC, and best, they are made with natural lipids of alimentary grade. In our studies, liposomes were made of soy phosphatidylcholine (SPC) with Stearic Acid or Calcium Stearate as membrane stabilizer. They encapsulated BC as vitamin E, vitamin C and folic acid (B9). The liposome’s design strategy is that SPC lipid’s components are BC like choline and essential fatty acids. These liposomes preserved and maintain the activity of the thermolabile vitamins C and B9. Like milk and fruit juice, in various food types can incorporate liposomes protecting BC. A series of laboratory studies will be performed to select the most stable liposomal formulations, like characterization, encapsulation efficiency, physicochemical, microbiological, thermal and sensory stability. Liposomes- BC design and development are discussed in the chapter. The food heat treatment and the conditions/storage time are also crucial and must be considered in these studies. Finally, incorporating the BC into a food production line is feasible with an excellent economic prospect until supermarket shelves are reached, like our food product proposal.",signatures:"Marina Marsanasco and Silvia del Valle Alonso",downloadPdfUrl:"/chapter/pdf-download/75459",previewPdfUrl:"/chapter/pdf-preview/75459",authors:[{id:"203036",title:"Dr.",name:"Silvia Del Valle",surname:"Alonso",slug:"silvia-del-valle-alonso",fullName:"Silvia Del Valle Alonso"},{id:"336784",title:"Dr.",name:"Marina",surname:"Marsanasco",slug:"marina-marsanasco",fullName:"Marina Marsanasco"}],corrections:null},{id:"78746",title:"Sustainable and Healthy Food Ingredients: Characterization and Application in Functional Products",doi:"10.5772/intechopen.100165",slug:"sustainable-and-healthy-food-ingredients-characterization-and-application-in-functional-products",totalDownloads:185,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Nowadays, and considering the increasing pieces of evidence of health-promoting abilities of numerous food classes, a pronounced market pressure has been observed both in agricultural and biotechnological industries. Thus, while the development of functional foods seems to be conceived as an interesting trend with large market potential, the increasing demand and interest of sustainable food ingredients seems also promissory. In order to contribute to this approach, the proposal chapter will provides a comprehensive overview of the healthy and sustainable ingredients as edible mushrooms, legumes and bison emphasizing the characterization and application of those as natural ingredients in functional food products.",signatures:"Ţibulcă Dorin and Fogarasi Melinda",downloadPdfUrl:"/chapter/pdf-download/78746",previewPdfUrl:"/chapter/pdf-preview/78746",authors:[{id:"414876",title:"Dr.",name:"Melinda",surname:"Fogarasi",slug:"melinda-fogarasi",fullName:"Melinda Fogarasi"},{id:"429539",title:"Dr.",name:"Tibulca",surname:"Dorin",slug:"tibulca-dorin",fullName:"Tibulca Dorin"}],corrections:null},{id:"75960",title:"Eat Tasty and Healthy: Role of Polyphenols in Functional Foods",doi:"10.5772/intechopen.96577",slug:"eat-tasty-and-healthy-role-of-polyphenols-in-functional-foods",totalDownloads:341,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Adverse reactions to food such as allergies and celiac disease are increasingly recognized as a growing public health burden. There is currently no cure for these diseases so that there is an unmet need to evaluate different nutritional approaches aiming at improving the quality of life of affected patients and their families. In this context, healthy promising nature-derived compounds, most of which contained in fruits and vegetables, have been studied as an alternative to attenuate the epidemic. Indeed, phenolic compounds have become an emerging field of interest in nutrition in the last decades. A growing build of research suggests that phenolic compounds inhibit pro-inflammatory transcription factors by interacting with proteins involved in gene expression and cell signaling, leading to protective effects against many inflammation-mediated chronic diseases. However, the use of phenolic compounds as attenuating agents of immune reactions to food has to be aligned to the organoleptic characteristics of food, since many compounds present unpleasant taste properties, namely bitter taste and astringency. In this framework, tasty but healthy phenolic compounds arise as attractive ingredients in the design and formulation of functional foods. This book chapter is focused on revisiting the organoleptic properties of phenolic compounds while evaluating the role of these compounds in health promoting actions, namely the management of immune reactions to food such as Food Allergies and Celiac Disease.",signatures:"Catarina Bessa-Pereira, Ricardo Dias, Elsa Brandão, Nuno Mateus, Victor de Freitas, Susana Soares and Rosa Pérez-Gregorio",downloadPdfUrl:"/chapter/pdf-download/75960",previewPdfUrl:"/chapter/pdf-preview/75960",authors:[{id:"313609",title:"Dr.",name:"Susana",surname:"Soares",slug:"susana-soares",fullName:"Susana Soares"},{id:"336758",title:"Assistant Prof.",name:"Maria Rosa",surname:"Perez-Gregorio",slug:"maria-rosa-perez-gregorio",fullName:"Maria Rosa Perez-Gregorio"},{id:"345790",title:"Prof.",name:"Nuno",surname:"Mateus",slug:"nuno-mateus",fullName:"Nuno Mateus"},{id:"345791",title:"Dr.",name:"Elsa",surname:"Brandão",slug:"elsa-brandao",fullName:"Elsa Brandão"},{id:"345792",title:"Dr.",name:"Catarina",surname:"Bessa Pereira",slug:"catarina-bessa-pereira",fullName:"Catarina Bessa Pereira"},{id:"345793",title:"Dr.",name:"Ricardo",surname:"Dias",slug:"ricardo-dias",fullName:"Ricardo Dias"},{id:"345794",title:"Prof.",name:"Victor",surname:"De Freitas",slug:"victor-de-freitas",fullName:"Victor De Freitas"}],corrections:null},{id:"75985",title:"The Impact of Dietary Compounds in Functional Foods on MicroRNAs Expression",doi:"10.5772/intechopen.96746",slug:"the-impact-of-dietary-compounds-in-functional-foods-on-micrornas-expression",totalDownloads:299,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"MicroRNAs (miRNAs) are a class of non-coding endogenous RNA molecules that are involved in post-transcriptional gene silencing via binding to their target messenger RNA, leading to mRNA degradation or translational repression. MicroRNAs can be modulated by several factors including hormones, transcription factors, and dietary compounds. These biologically active compounds have positive impact on the progression of human pathology including non-communicable diseases, which indicating that administration of diet may have potential as therapeutic agents in modulating the risk of chronic diseases. Interestingly, evidence emerging in recent years suggests that dietary miRNAs can be absorbed in human circulation, modulated human gene expression and biological functions. The exploitation of the miRNA functioning within different origins, cellular miRNAs and dietary miRNAs will help us to understand the molecular machinery as well as the regulatory mechanisms involved in fundamentally important biological processes. Therefore, this knowledge may be applied of natural bioactive compounds in preventive or therapeutic approaches.",signatures:"Wittaya Chaiwangyen",downloadPdfUrl:"/chapter/pdf-download/75985",previewPdfUrl:"/chapter/pdf-preview/75985",authors:[{id:"337181",title:"Assistant Prof.",name:"Wittaya",surname:"Chaiwangyen",slug:"wittaya-chaiwangyen",fullName:"Wittaya Chaiwangyen"}],corrections:null},{id:"76273",title:"Functional-Antioxidant Food",doi:"10.5772/intechopen.96619",slug:"functional-antioxidant-food",totalDownloads:279,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Nowadays, people face many different dangers, such as stress, unsafety food, and environmental pollution, but not everyone suffers. Meanwhile, free radicals are the biggest threat for humans because they lead to over 80 different diseases composed of aging. Free radicals can only be eliminated or minimized with antioxidant foods or antioxidants. The chapter on the functional-antioxidant food presents the antioxidant functional food concept, the classification, the structure, and the extraction process of antioxidant ingredients. Various antioxidant substances such as protein (collagen), polysaccharides (fucoidans, alginates, glucosamines, inulins, laminarins, ulvans, and pectins), and secondary metabolites (polyphenols (phlorotannins, lignins, polyphenols), alkaloids, and flavonoids) also present. The production technology, the mechanism, the opportunity, and the challenge of antioxidants functional food also present in the current chapter. The current chapter also gives the production process of functional-antioxidant food composed of the capsule, the tablet, tube, the pills, the powder, and the effervescent tablet.",signatures:"Nguyen Xuan Hoan, Le Thi Hong Anh, Duong Hong Quan, Dang Xuan Cuong, Hoang Thai Ha, Nguyen Thi Thao Minh, Dao Trong Hieu, Nguyen Dinh Thuat, Pham Duc Thinh and Dang Thi Thanh Tuyen",downloadPdfUrl:"/chapter/pdf-download/76273",previewPdfUrl:"/chapter/pdf-preview/76273",authors:[{id:"286568",title:"Ph.D.",name:"Dang Xuan",surname:"Cuong",slug:"dang-xuan-cuong",fullName:"Dang Xuan Cuong"},{id:"356459",title:"Dr.",name:"Nguyen Xuan",surname:"Hoan",slug:"nguyen-xuan-hoan",fullName:"Nguyen Xuan Hoan"},{id:"356460",title:"Dr.",name:"Le Thi",surname:"Hong Anh",slug:"le-thi-hong-anh",fullName:"Le Thi Hong Anh"},{id:"356461",title:"Dr.",name:"Duong Hong",surname:"Quan",slug:"duong-hong-quan",fullName:"Duong Hong Quan"},{id:"356462",title:"Dr.",name:"Hoang Thai",surname:"Ha",slug:"hoang-thai-ha",fullName:"Hoang Thai Ha"},{id:"356463",title:"Dr.",name:"Nguyen Thi Thao",surname:"Minh",slug:"nguyen-thi-thao-minh",fullName:"Nguyen Thi Thao Minh"},{id:"356464",title:"Dr.",name:"Dao Trong",surname:"Hieu",slug:"dao-trong-hieu",fullName:"Dao Trong Hieu"},{id:"356465",title:"Dr.",name:"Nguyen Dinh",surname:"Thuat",slug:"nguyen-dinh-thuat",fullName:"Nguyen Dinh Thuat"},{id:"356466",title:"Dr.",name:"Pham Duc",surname:"Thinh",slug:"pham-duc-thinh",fullName:"Pham Duc Thinh"},{id:"356467",title:"Dr.",name:"Dang Thi Thanh",surname:"Tuyen",slug:"dang-thi-thanh-tuyen",fullName:"Dang Thi Thanh Tuyen"}],corrections:null},{id:"76403",title:"Physiological and Cellular Targets of Neurotrophic Anxiolytic Phytochemicals in Food and Dietary Supplements",doi:"10.5772/intechopen.97565",slug:"physiological-and-cellular-targets-of-neurotrophic-anxiolytic-phytochemicals-in-food-and-dietary-sup",totalDownloads:376,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Diet impacts anxiety in two main ways. First anxiety can be caused by deficiencies in antioxidants, neurotransmitter precursors, amino acids, cations and vitamins and other cofactors. Second, anxiety can be reduced by anxiolytic nutraceuticals which are food molecules that bind to molecular targets of the amygdala and the hypothalamus-pituitary–adrenal axis (HPA-axis). Anxiety is a feeling of fear that arises from a perceived threat and can be a beneficial coping mechanism to threats and stressors. However excessive anxiety is a disorder that interferes with healthy responses to stressors. The amygdala is responsible for assigning value to a threat or stressor and triggering the HPA-axis to support the body wide system responses to the threat. The amygdala also communicates with the neuroplastic learning and memory centers of the hippocampus to fix or set a learned value to the threat. Interestingly, many anxiolytic nutraceuticals that show benefits in human clinical trials have neurotrophic activity and increase neuronal plasticity. Moreover, anxiolytic nutraceuticals either act like the neurotrophins, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF and neurotrophin-3 (NT3) by either directly binding to or potentiating the tyrosine receptor kinase (TRK) family of receptors (TRKA, TRKB and TRKC) and activating the ERK1/2 signal transduction pathway associated with neurite outgrowth and neural plasticity. This chapter will explore the neuritogenic activity of clinically proven plant-based anxiolytic nutraceuticals and examine the commonality of TRKA-C receptors and the ERK1/2 signaling pathway in the pharmacological and nutraceutical treatment of anxiety disorders.",signatures:"Benjamin S. Weeks, Samuel D. Weeks, Amanda Kim, Landon Kessler and Pedro P. Perez",downloadPdfUrl:"/chapter/pdf-download/76403",previewPdfUrl:"/chapter/pdf-preview/76403",authors:[{id:"44649",title:"Prof.",name:"Benjamin S.",surname:"Weeks",slug:"benjamin-s.-weeks",fullName:"Benjamin S. Weeks"},{id:"345672",title:"Dr.",name:"Samuel D.",surname:"Weeks",slug:"samuel-d.-weeks",fullName:"Samuel D. Weeks"},{id:"345692",title:"Dr.",name:"Amanda",surname:"Kim",slug:"amanda-kim",fullName:"Amanda Kim"},{id:"345693",title:"Dr.",name:"Landon",surname:"Kessler",slug:"landon-kessler",fullName:"Landon Kessler"},{id:"346663",title:"Dr.",name:"Pedro",surname:"Perez",slug:"pedro-perez",fullName:"Pedro Perez"}],corrections:null},{id:"76350",title:"Natural Compounds with Antioxidant Activity-Used in the Design of Functional Foods",doi:"10.5772/intechopen.97364",slug:"natural-compounds-with-antioxidant-activity-used-in-the-design-of-functional-foods",totalDownloads:276,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter is intended to describe the main antioxidants used in the design and construction of functional foods. Defining the role of antioxidants, in the main redox processes in which certain oxidoreductases are involved, the best way of monitoring the activity of certain coenzymes of these oxidoreductases, will be established the main criteria in the design of sustainable functional foods. In addition, the importance of some coenzymes (FMN, FMNH + H +, NAD, NADH + H+) in preserving the activity of some valuable bio-compounds (with the role of antioxidants) in functional foods will be highlighted. Antioxidants are good disease-fighters, protecting our bodies from free radicals’ attacks that would otherwise damage of the human cellular structures. Knowing and supporting the activity of the main compounds (with antioxidant activity) are operations that improve the reaction mechanisms of redox processes and can significantly contribute to achieving good functional foods - able to regulate the acid–base balance of the body and improve the metabolic processes from the consumer body.",signatures:"Petre Săvescu",downloadPdfUrl:"/chapter/pdf-download/76350",previewPdfUrl:"/chapter/pdf-preview/76350",authors:[{id:"336892",title:"Prof.",name:"Petre",surname:"Săvescu",slug:"petre-savescu",fullName:"Petre Săvescu"}],corrections:null},{id:"76000",title:"Theoretical Studies on Anti-Oxidant Activity of the Phytochemical, Coumestrol and Its Derivatives",doi:"10.5772/intechopen.96967",slug:"theoretical-studies-on-anti-oxidant-activity-of-the-phytochemical-coumestrol-and-its-derivatives",totalDownloads:131,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Free radical-induced changes in cellular and organ levels have been studied as a possible underlying cause of various adverse health conditions. Important research efforts have, therefore, been made to discover more powerful and potent antioxidants/free radical scavengers for the treatment of these adverse conditions. The phytoestrogen coumestrol intensively attracted scientific interest due to their efficient pharmacological activities. In this scenario, DFT studies were carried out to test the antiradical activities of coumestrol and its derivatives. The results obtained from FEDAM plots demonstrated that the coumestrol derivatives pointed out were good radical scavengers relative to the parent molecule in the gas phase. The derivatives whose 16thposition substituted with electron-donating groups like -NH2, -OCH3 and -CH3 showed good antioxidant capacity. Three antioxidant mechanisms, including hydrogen atom transfer (HAT), electron transfer followed by proton transfer (SET-PT), and sequential proton loss electron transfer (SPLET), were investigated by measuring thermodynamic parameters.",signatures:"Puttanveedu Vinduja and Karuvanthodi Muraleedharan",downloadPdfUrl:"/chapter/pdf-download/76000",previewPdfUrl:"/chapter/pdf-preview/76000",authors:[{id:"269630",title:"Dr.",name:"Karuvanthodi",surname:"Muraleedharan",slug:"karuvanthodi-muraleedharan",fullName:"Karuvanthodi Muraleedharan"},{id:"345668",title:"Ms.",name:"Puttanveedu",surname:"Vinduja",slug:"puttanveedu-vinduja",fullName:"Puttanveedu Vinduja"}],corrections:null},{id:"75848",title:"Functional Foods for the Management of Non-Alcoholic Fatty Liver Disease",doi:"10.5772/intechopen.96317",slug:"functional-foods-for-the-management-of-non-alcoholic-fatty-liver-disease",totalDownloads:589,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Non-alcoholic fatty liver disease (NAFLD) is increasingly evolving and a critical public health concern, raising the likelihood of liver cirrhosis, type 2 diabetes and cardiac problems. Existing epidemics of obesity and sedentary life style have lead to NAFLD’s elevated prevalence. In recent years there is profound change in the diet pattern, particularly the hypercaloric fat and carbohydrates for preventing or treating chronic liver disorders such as NASH and NAFLD. Functional and nutritional foods have contributed significantly to NAFLDimprovement and management. The justification for exploring functional foods as anti-NAFLD candidates for the chronic liver disease prevention is derived knowledge from in vitro and in vivo models. The findings from the in vitro and in vivo studies confirmed that these compounds are healthy, efficient, reversible inhibitors, when sufficiently consumed over a lifetime without severe toxicity, suitable for clinical trials and potentially becoming low-cost medication.",signatures:"Venkateish V. Palanisamy, Nivya Vijayan, Vani Vijay, Baskaran Vallikannan and Madan Kumar Perumal",downloadPdfUrl:"/chapter/pdf-download/75848",previewPdfUrl:"/chapter/pdf-preview/75848",authors:[{id:"194534",title:"Dr.",name:"Baskaran",surname:"Vallikannan",slug:"baskaran-vallikannan",fullName:"Baskaran Vallikannan"},{id:"334486",title:"Dr.",name:"Madan Kumar",surname:"Perumal",slug:"madan-kumar-perumal",fullName:"Madan Kumar Perumal"},{id:"341640",title:"Mrs.",name:"Nivya",surname:"Vijayan",slug:"nivya-vijayan",fullName:"Nivya Vijayan"},{id:"341643",title:"Mr.",name:"Venkatiesh",surname:"V. Palanisamy",slug:"venkatiesh-v.-palanisamy",fullName:"Venkatiesh V. Palanisamy"},{id:"341644",title:"Ms.",name:"Vani",surname:"Vijay",slug:"vani-vijay",fullName:"Vani Vijay"}],corrections:null},{id:"75603",title:"Role of Functional Food in Treating and Preventing Cardiovascular Diseases",doi:"10.5772/intechopen.96614",slug:"role-of-functional-food-in-treating-and-preventing-cardiovascular-diseases",totalDownloads:178,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Cardiovascular diseases (CVDs) are still a major cause of mortality worldwide and are a serious health problem. Various factors that contribute toward CVDs include hypertension, tobacco use, physical inactivity, diabetes mellitus, obesity and overweight, alcohol, dietary factors and psychosocial aspects such as stress, anxiety and depression. Nutraceuticals and diet are very important for prevention of CVDs. The potential of nutraceuticals or functional food in mitigating risk of CVDs is discussed. Functional food with health related properties include fruit and vegetable, fish, legumes, nuts, soya protein, coffee, tea, chocolate, animal based functional food. In addition, some diet plans have shown the potential of reducing the incidence of CVDs. This includes the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), Okinawan and vegetarian diets. This chapter examines the risk factors of CVDs, including hypertension, tobacco usage, physical inactivity, diabetes mellitus, overweight and obesity. The chapter also brings to the fore, functional foods with properties related to health and effect of dietary patterns in the treatment and prevention of CVDs.",signatures:"Mpho Edward Mashau and Shonisani Eugenia Ramashia",downloadPdfUrl:"/chapter/pdf-download/75603",previewPdfUrl:"/chapter/pdf-preview/75603",authors:[{id:"201858",title:"Mr.",name:"Mpho E.",surname:"Mashau",slug:"mpho-e.-mashau",fullName:"Mpho E. Mashau"},{id:"229973",title:"Ms.",name:"Shonisani Eugenia",surname:"Ramashia",slug:"shonisani-eugenia-ramashia",fullName:"Shonisani Eugenia Ramashia"}],corrections:null},{id:"77005",title:"Functional and Therapeutic Potential of γ-Oryzanol",doi:"10.5772/intechopen.97666",slug:"functional-and-therapeutic-potential-of-em-em-oryzanol",totalDownloads:212,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter summarizes the entire literature available on the nutritional value and diverse therapeutic potentials Gamma-oryzanol, a nutraceutical obtained from rice brain oil, composed of a mixture of γ - oryzanol, a mixture of ferulic acid esters of phytosterols and triterpenoids, cycloartenyl ferulate, 24-methylenecycloartanyl ferulate, and campesteryl ferulate. In brief, the review covers the aspects such as the antioxidant mechanisms, effects on immune system, lipid disorders, diabetes, obesity and inflammation with the details of preclinical experiments, models and observations. Among the other highlights are the hepatoprotective, neuroprotective role in various neurological disorders such as Alzheimer’s, anxiety, Parkinson’s disease and wound healing effects. An overview of the sources, chemistry, physicochemical properties, pharmacokinetics and toxicity studies are also included.",signatures:"Aasiya Sulaiman, Aisha Sulaiman, Mehtap Sert, Mohammed Safwan Ali Khan and Mansoor A. Khan",downloadPdfUrl:"/chapter/pdf-download/77005",previewPdfUrl:"/chapter/pdf-preview/77005",authors:[{id:"339886",title:"Assistant Prof.",name:"Mohammed Safwan",surname:"Ali Khan",slug:"mohammed-safwan-ali-khan",fullName:"Mohammed Safwan Ali Khan"},{id:"356526",title:"Ms.",name:"Aasiya",surname:"Sulaiman",slug:"aasiya-sulaiman",fullName:"Aasiya Sulaiman"},{id:"356527",title:"Ms.",name:"Aisha",surname:"Sulaiman",slug:"aisha-sulaiman",fullName:"Aisha Sulaiman"},{id:"356528",title:"Ms.",name:"Mehtap",surname:"Sert",slug:"mehtap-sert",fullName:"Mehtap Sert"},{id:"357106",title:"Prof.",name:"Mansoor",surname:"Ali Khan",slug:"mansoor-ali-khan",fullName:"Mansoor Ali Khan"}],corrections:null},{id:"75637",title:"Dietary Patterns for Immunity Support and Systemic Inflammation against Infections: A Narrative Review",doi:"10.5772/intechopen.96610",slug:"dietary-patterns-for-immunity-support-and-systemic-inflammation-against-infections-a-narrative-revie",totalDownloads:320,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Nutrition has been recognized to play a regulatory role in human immune response and inflammation which may affect the pathogenesis of diseases. Current evidence suggests that the habitual dietary pattern therapeutical approach provides more synergistic beneficial action than the intervention of a single nutrient constituent. Several healthy dietary patterns are essential for the human immunity support against infectious diseases through alleviation of systemic inflammation. Long-term dietary patterns may affect the diversity of intestinal microbiota composition and lead to the decrease of pro-inflammatory cytokines from immune-related cells. Protease that may cause gut barrier breakdown (leaky gut) can be reduced either thus lessen translocation of endogenous bacterial endotoxin such as lipopolysaccharides (LPS) from the gut lumen to the bloodstream. In this review, we discuss the relationship between common healthy food-based dietary patterns with the protection of infectious diseases as a result of improvement in immune function and low-grade inflammatory indices. In contrary to the deleterious impact of the western diet, healthy eating habits (Mediterranean diet, dietary approaches to stop hypertension, plant-based diet, ketogenic diet) are associated with reduced susceptibility to infectious disease by the improvement of certain underlying metabolic comorbidities. Further studies are needed to determine suitable strategic implications of healthy dietary patterns on infectious disease mitigation in a particular context.",signatures:"Budhi Setiawan and Masfufatun Masfufatun",downloadPdfUrl:"/chapter/pdf-download/75637",previewPdfUrl:"/chapter/pdf-preview/75637",authors:[{id:"232747",title:"Dr.",name:"Budhi",surname:"Setiawan",slug:"budhi-setiawan",fullName:"Budhi Setiawan"},{id:"346372",title:"Dr.",name:"Masfufatun",surname:"Masfufatun",slug:"masfufatun-masfufatun",fullName:"Masfufatun Masfufatun"}],corrections:null},{id:"76421",title:"Disease Modifying Potential of Functional Foods for Neurodegenerative Disorders: Status Update on Regulatory Compliance",doi:"10.5772/intechopen.97546",slug:"disease-modifying-potential-of-functional-foods-for-neurodegenerative-disorders-status-update-on-reg",totalDownloads:255,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Progressive loss of functional neurons is typically characterized as neurodegeneration. This is particularly pronounced during aging and results in debilitating conditions such as Parkinson’s disease and Alzheimer’s disease. Symptoms appear typically after 70–80% neuronal loss, resulting in irreversible damage. Several drugs have been clinically approved but they only alleviate symptoms and additionally lead to undesirable side effects. Hence there is a dire need for drugs and/or supplements which address this lacuna. Functional foods are known to offer health benefits beyond their attributed nutritional values. Unlike dietary supplements which are made from foods or food-like substances with enriched nutritional value, functional foods are foods that are modified for greater nutritional value. Conceptually, as an expansion of dietary supplements, functional foods are known to be neuroprotective. Here we discuss functional foods which can potentially be used as adjunctive therapy, with a note on the regulatory compliance.",signatures:"Christofer Thomas, Borehalli Mayegowda Shilpa and Rajeswara Babu Mythri",downloadPdfUrl:"/chapter/pdf-download/76421",previewPdfUrl:"/chapter/pdf-preview/76421",authors:[{id:"37274",title:"Dr.",name:"Rajeswara Babu",surname:"Mythri",slug:"rajeswara-babu-mythri",fullName:"Rajeswara Babu Mythri"},{id:"336231",title:"Dr.",name:"Borehalli",surname:"Mayegowda Shilpa",slug:"borehalli-mayegowda-shilpa",fullName:"Borehalli Mayegowda Shilpa"},{id:"336232",title:"Dr.",name:"Christofer",surname:"Thomas",slug:"christofer-thomas",fullName:"Christofer Thomas"}],corrections:null},{id:"77796",title:"Therapeutic Potential of Dietary Polyphenols",doi:"10.5772/intechopen.99177",slug:"therapeutic-potential-of-dietary-polyphenols",totalDownloads:196,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The chapter summarizes available research on polyphenols and the potential for polyphenol based therapeutics. Polyphenols have the potential to be used in a multi-target fashion therapeutically. The majority of the polyphenol benefits appear to share positive effects across multiple disease states including inflammatory diseases, diseases of metabolic dysregulation and cancer. The reviewed literature includes human, animal and cell culture based studies. Selected mechanisms within each disease state are highlighted including interleukin inflammatory markers, NF-κB, acetyl-CoA concentration regulation of metabolism, and p-glycoprotein multidrug efflux pump associated with cancer treatment failures. Reviewed studies discuss polyphenols inhibiting transcription factors that control expression on inflammatory factors as well as activating other transcription factors that increase expression of enzymes protective of oxidative damage. Levels of metabolic regulatory enzymes are also affected positively by polyphenol addition through epigenetic modifications. Epigenetic modifications affecting cancer development and progression appear positively affected by polyphenol treatment. Additionally, oxidative damage protection of normal cells can be achieved by polyphenol treatment thus limiting chemotherapeutic damage. Upon review of the available literature, a strong case for the potential use of polyphenols in therapeutic situations stands out. Potential risks included are that the purity and specific concentrations required to achieve therapeutic benefits without potential side effects need to be examined prior to the adoption of therapeutics.",signatures:"Amy L. Stockert and Seth Hall",downloadPdfUrl:"/chapter/pdf-download/77796",previewPdfUrl:"/chapter/pdf-preview/77796",authors:[{id:"103192",title:"Dr.",name:"Amy L.",surname:"Stockert",slug:"amy-l.-stockert",fullName:"Amy L. Stockert"},{id:"414450",title:"Mr.",name:"Seth",surname:"Hall",slug:"seth-hall",fullName:"Seth Hall"}],corrections:null},{id:"75487",title:"Flour-Based Confectionery as Functional Food",doi:"10.5772/intechopen.95876",slug:"flour-based-confectionery-as-functional-food",totalDownloads:364,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Nowadays, the flour-based confectionery industry is facing different challenges in reducing caloric and increasing nutritive values in order to produce healthier products, given that consumption of flour-based confectionery products has been growing steadily worldwide. In addition to wheat flour, these products include sugar and fat, which contribute to high energy value, but have few micronutrients and are mostly poor in nutritional terms. Due to frequency of consumption, they can harm a balanced diet, especially when it comes to children and young people. Flour-based confectionery is highly suitable for enrichment with ingredients that have pronounced functional properties. In this sense, the text offers some possibilities for improving such products through different approaches and presents new trends in developing functional, flour-based confectionery by using different supplements that could decrease caloric value, improve nutritional and non-nutritional values and develop products with pronounced functional properties.",signatures:"Sanja Oručević Žuljević and Asima Akagić",downloadPdfUrl:"/chapter/pdf-download/75487",previewPdfUrl:"/chapter/pdf-preview/75487",authors:[{id:"336437",title:"Prof.",name:"Asima",surname:"Akagić",slug:"asima-akagic",fullName:"Asima Akagić"},{id:"336783",title:"Prof.",name:"Sanja",surname:"Oručević Žuljević",slug:"sanja-orucevic-zuljevic",fullName:"Sanja Oručević Žuljević"}],corrections:null},{id:"77462",title:"Bitter Melon: A Multifunctional Medicinal Plant with Powerful Bioactive Compounds",doi:"10.5772/intechopen.98812",slug:"bitter-melon-a-multifunctional-medicinal-plant-with-powerful-bioactive-compounds",totalDownloads:276,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Nature is full of poisons as well as life-saving entities. Extracts of natural products in medicinal plants have been used for thousands of years in traditional medicine throughout the World. Bitter melon (Momordica charantia) is a member of Cucurbitaceae family, widely distributed in tropical regions of the World, that has been used in folk medicine for the treatment of diabetes mellitus, and its fruit has been used as a vegetable for thousands of years. It contains phytochemicals, flavonoids, triterpenes, saponins, ascorbic acid, steroids, proteins, and polysaccharides. This plant is a traditional herbal medicine, possesses various biological, medicinal activities and pharmacological functions, namely antidiabetic, anthelmintic, contraceptive, antimalarial, laxative, antihyperglycemic, antimutagenic, antiulcer, antilipolytic, antifertility, hepatoprotective, anticancer, antibacterial, antiviral, antitumor, immunomodulation, antioxidant, antidiabetic, and anti-inflammatory activities of M. charantia have been reported. Its fruit has a special bitter taste, parts of M. charantia, such as fruits, vines, leaves and even roots have been used as folk medicine for the remedy of diseases like toothache, diarrhea, and diabetes. It is also used for the treatment of eczema, gout, jaundice, pneumonia, psoriasis, and rheumatism. These beneficial effects are attributed to the various bioactive components of M. charantia, which are important sources of phytoconstituents used to treat various diseases since ancient times. This chapter reviews various aspects of the results of investigations involving M. charantia in the recent years, providing a comprehensive overview of the phytochemical application of M. charantia to attract more attention to their biological activities for better utilization of M. charantia; focusing on the review of benefits that bitter melon offers in terms of its potential as a source of bioactive compounds and its role in the control of different diseases.",signatures:"Fadime Eryılmaz Pehlivan",downloadPdfUrl:"/chapter/pdf-download/77462",previewPdfUrl:"/chapter/pdf-preview/77462",authors:[{id:"200567",title:"Dr.",name:"Fadime",surname:"Eryılmaz Pehlivan",slug:"fadime-eryilmaz-pehlivan",fullName:"Fadime Eryılmaz Pehlivan"}],corrections:null},{id:"77183",title:"Evaluation of the Effect of Fruit Juice Containing Bacillus Coagulans Probiotic Supplement on the Level of Immunoglobulins A, M and Lymphocytes in Two-Speed Athletes",doi:"10.5772/intechopen.98370",slug:"evaluation-of-the-effect-of-fruit-juice-containing-bacillus-coagulans-probiotic-supplement-on-the-le",totalDownloads:242,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Probiotics exert beneficial effects on their host health by creating microbial balance in the digestive system. The role of some probiotic strains in strengthening the immune system and reducing the risk of diseases, especially respiratory infections, has been proven in previous studies. Aim: The aim of this study was to evaluate the effect of probiotic supplementation containing Bacillus coagulans on the Runner athletes immune system. In this study, the effect of Bacillus coagulans probiotic on immunoglobulins A, M and monocytes count 60 male athlete sprints Evaluates that which were randomly divided into two groups of 30.For 3 months, the experimental group received a daily glass of probiotic juice containing 109 cfu / ml containing probiotic supplement and the control group received plain and no supplemental juice. During the study period, once every 2 weeks, One day after exercise (running 200 meters), blood samples were taken from all participants Then In the collected samples, IgA, IgM and lymphocytes were evaluated. Consumption of probiotic juice containing 2 × 109 f cfu/ml Bacillus coagulans probiotic supplement showed a significant difference in the amount of IgA, IgM and Lymphocyte between the experimental group and the control group. The results of this study showed that the consumption of juice containing probiotic supplement Bacillus coagulans can increase the level of immune factors IgM, IgA, lymphocytes and prevent the occurrence of diseases, especially respiratory infections, by improving the function of the immune system.",signatures:"Elahe Ebrahimi, Maryam Golshahi, Samane Yazdi and Mohammad Mehdi Pirnia",downloadPdfUrl:"/chapter/pdf-download/77183",previewPdfUrl:"/chapter/pdf-preview/77183",authors:[{id:"275443",title:"MSc.",name:"Elahe",surname:"Ebarhimi",slug:"elahe-ebarhimi",fullName:"Elahe Ebarhimi"}],corrections:null},{id:"77413",title:"Oilseeds as Functional Foods: Content and Composition of Many Phytochemicals and Therapeutic Alternatives",doi:"10.5772/intechopen.97794",slug:"oilseeds-as-functional-foods-content-and-composition-of-many-phytochemicals-and-therapeutic-alternat",totalDownloads:201,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Oilseeds composition has been studied extensively, but recently it has been thoroughly investigated considering especially the phytochemicals representing the minor components. This interest is connected with the activity of such compounds against cardiovascular diseases, lipid oxidation, protein cross-linking and DNA mutations and hemostasis function, which prevent the attack of biomolecules by free radicals. This chapter book could aim to give an overview of the different uses of several oilseeds as bioactive foods, focusing on their active constituents (phytosterols, polyphenols, tocopherols, tocotrienols, and carotenoids) and their content in oilseeds. We will also focus on the beneficial aspects of theses nutraceuticals in human health.",signatures:"Aicha O. Cherif",downloadPdfUrl:"/chapter/pdf-download/77413",previewPdfUrl:"/chapter/pdf-preview/77413",authors:[{id:"66192",title:"Dr.",name:"Aicha Olfa",surname:"Cherif",slug:"aicha-olfa-cherif",fullName:"Aicha Olfa Cherif"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6669",title:"Meat Science and Nutrition",subtitle:null,isOpenForSubmission:!1,hash:"bca2d87ed258a60a9c92c5c6056d1465",slug:"meat-science-and-nutrition",bookSignature:"Muhammad Sajid Arshad",coverURL:"https://cdn.intechopen.com/books/images_new/6669.jpg",editedByType:"Edited by",editors:[{id:"192998",title:"Dr.",name:"Muhammad Sajid",surname:"Arshad",slug:"muhammad-sajid-arshad",fullName:"Muhammad Sajid Arshad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"497",title:"Soybean and Nutrition",subtitle:null,isOpenForSubmission:!1,hash:"11aa0c9ed0f6ea8da765be93b50954bb",slug:"soybean-and-nutrition",bookSignature:"Hany El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/497.jpg",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"496",title:"Soybean and Health",subtitle:null,isOpenForSubmission:!1,hash:"66d40dbc031b2825ba95f7ac2bfae1b6",slug:"soybean-and-health",bookSignature:"Hany El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/496.jpg",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6678",title:"Antioxidants in Foods and Its Applications",subtitle:null,isOpenForSubmission:!1,hash:"819eb2d8d2c889ef23affd7fd01e4e98",slug:"antioxidants-in-foods-and-its-applications",bookSignature:"Emad Shalaby and Ghada Mostafa Azzam",coverURL:"https://cdn.intechopen.com/books/images_new/6678.jpg",editedByType:"Edited by",editors:[{id:"63600",title:"Prof.",name:"Emad",surname:"Shalaby",slug:"emad-shalaby",fullName:"Emad Shalaby"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1018",title:"Milk Production",subtitle:"An Up-to-Date Overview of Animal Nutrition, Management and Health",isOpenForSubmission:!1,hash:"0666bd242c21546d0c83c0290bd114ea",slug:"milk-production-an-up-to-date-overview-of-animal-nutrition-management-and-health",bookSignature:"Narongsak Chaiyabutr",coverURL:"https://cdn.intechopen.com/books/images_new/1018.jpg",editedByType:"Edited by",editors:[{id:"76047",title:"Prof.",name:"Narongsak",surname:"Chaiyabutr",slug:"narongsak-chaiyabutr",fullName:"Narongsak Chaiyabutr"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2066",title:"Milk Production",subtitle:"Advanced Genetic Traits, Cellular Mechanism, Animal Management and Health",isOpenForSubmission:!1,hash:"0bce9f57b06503666b182457b414a9de",slug:"milk-production-advanced-genetic-traits-cellular-mechanism-animal-management-and-health",bookSignature:"Narongsak Chaiyabutr",coverURL:"https://cdn.intechopen.com/books/images_new/2066.jpg",editedByType:"Edited by",editors:[{id:"76047",title:"Prof.",name:"Narongsak",surname:"Chaiyabutr",slug:"narongsak-chaiyabutr",fullName:"Narongsak Chaiyabutr"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6155",title:"Diabetes Food Plan",subtitle:null,isOpenForSubmission:!1,hash:"b826ff12304ae270954a41210f4e1582",slug:"diabetes-food-plan",bookSignature:"Viduranga Waisundara",coverURL:"https://cdn.intechopen.com/books/images_new/6155.jpg",editedByType:"Edited by",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. 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Toxicity, Human Health and Environment",slug:"nanomaterials-toxicity-human-health-and-environment",publishedDate:"February 19th 2020",bookSignature:"Simona Clichici, Adriana Filip and Gustavo M. do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/8137.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"64160",title:"Prof.",name:"Simona",middleName:null,surname:"Clichici",slug:"simona-clichici",fullName:"Simona Clichici"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11867",leadTitle:null,title:"Echocardiography",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tAlthough the diagnosis and overall survival of patients with various cardiac diseases have improved in the last years, there still remains a significant proportion of patients with unfavorable prognoses. The evaluation of these patients necessitates effective imaging techniques in both diagnosis and long-term follow-up. Even though Cardiac Magnetic Resonance imaging is currently the imaging modality of choice for tissue characterization, advanced echocardiography represents a modern alternative. Speckle tracking echocardiography can be used to assess myocardial deformation at both segmental and global levels. Since distinct myocardial pathologies affect deformation differently, information about the underlying tissue can be offered by strain imaging. Echocardiography advances also show promising results in the improvement of diagnostic accuracy, management, and follow-up and a major advantage of echocardiography over other imaging modalities is the ability to use it in real-time, in the cardiac catheterization laboratory, allowing for the performance of imaging immediately before, during, and after interventional procedures. Furthermore, the prevalence of adult congenital heart disease continues to grow due to advances in surgical and diagnostic techniques. Echocardiography has proven to be a useful tool in the diagnosis and follow-up of these patients, both after percutaneous and surgical procedures, and its utility has expanded significantly due to the development of better technology. In addition, stress echocardiography could be useful in the evaluation of several cardiac diseases and should be preferred over other imaging modalities due to the lower cost, wider availability, and radiation-free nature.
\r\n\tThis book intends to provide the reader with a comprehensive overview of the current state-of-the-art novel imaging techniques by focusing on the most important evidence-based developments in this area.
Space weather is a fairly new field in science today and has very interesting effects on humans, environment and technology in general. Scientists are now studying space weather with a wide range of tools to try to learn more about the physical and chemical processes taking place in the upper atmosphere and beyond. One of these tools is Global Positioning System (GPS). GPS is currently one of the most popular global satellite positioning systems due to global availability of signal as well as performance. GPS is a satellite-based navigation radio system which is used to verify the position and time in space and on the Earth. GPS nowadays allows to measure positions in real time with an accuracy of few centimetres (Warnant et al., 2007). The advent of GPS has led to technical revolutions in navigation as well as in fields related to surveying. The GPS system - an all-weather satellite-based radio navigation system - can provide users on a world-wide basis with navigation, positioning, and time information which is not possible with conventional navigation and surveying methods.
\n\t\t\tApart from geodesy and geophysical interest, GPS has great importance in scientific applications. The GPS satellites that are orbiting the Earth, at altitudes of about 20,200 km, transmit signals that propagate through the ionosphere that exists at about 60 –1500 km above the Earth’s surface. The signals from the GPS satellites travel through the ionosphere on their way to receivers on the Earth’s surface. The free electrons populating this region of the atmosphere affect the propagation of the signals, changing their velocity and direction of travel as shown at figure 1. Due to the inhomogeneity of the propagation medium in the ionosphere, the GPS signal does not travel along a perfectly straight line (Ioannides & Strangeways, 2000). The effects of the ionosphere can cause range-rate errors for users of the GPS satellites who require high accuracy measurements (Bradford & Spilker, 1996).
\n\t\t\tIonosphere is highly variable in space and time (sunspot cycle, seasonal, and diurnal), with geographical location (polar, aurora zones, mid-latitudes and equatorial regions), and with certain solar-related ionospheric disturbances. Ionosphere research attracts significant attention from the GPS community because ionosphere range delay on GPS signals is a major error source in GPS positioning and navigation. The ionosphere has practical importance in GPS applications because it influences the transionospheric radio wave propagation. Observed ionospheric behaviour varies over the Earth and can be generalized into aurora, mid-latitude and equatorial regions. Ionospheric delays of 38 ~ 52 m were observed at low-latitude region during high solar activity period at an elevation cut off angle of 10˚ (Komjathy et al., 2002). The equatorial ionosphere differs significantly from what is typically observed at mid-latitudes. The geographic bands 10˚-15˚ north and south of the magnetic equator are referred to as the equatorial anomaly region, due to the occurrence of Appleton anomaly (Doherty et al., 2002).
\n\t\t\tExaggerated view of GPS signal geometric paths.
The parameter of ionosphere that produces most of the effects on radio signals is total electron content (TEC). By modelling TEC parameter, the evaluation of the ionospheric error and the correction of these ionospheric errors for differential GPS can be done. The ionosphere causes GPS signal delays to be proportional to TEC along the path from the GPS satellite to a receiver. TEC is defined by the integral of electron density in a 1 m2 column along the signal transmission path. TEC is a key parameter in the mitigation of ionospheric effects on radio system. The TEC measurements obtained from dual frequency GPS receivers are one of the most important methods of investigating the Earth’s ionosphere. The TEC itself is hard to accurately determine from the slant TEC because this depends on the sunspot activity, seasonal, diurnal and spatial variations and the line of sight which includes knowledge of the elevation and azimuth of the satellite. The highest TEC in the world occurs in the equatorial region. In Malaysia there are few corresponding research done on the low latitude (equatorial) ionosphere.
\n\t\t\tIonospheric research in the equator and tropical areas has sparked interests in several research groups. Ong and Kamarudin (2006) have conducted a research on the TEC distribution estimation with the Bent, IRI and Klobuchar modelling by using the GPS MASS station network. While Ho et al. (2002) reported on the typical hourly variations for quiet ionosphere over Malaysia for 24 hours on July 14, 2000. At Universiti Kebangsaan Malaysia (UKM) researchers have been analysing TEC since 1999. Abdullah et al. (2008) did an analysis of TEC determination over single GPS receiver station using Precise Point Positioning (PPP) technique. The ionosphere over Malaysia is unique because of its location near the equator line.
\n\t\t\tIn this chapter, the focus is placed on the implementation of the method to the local area GPS reference network and the data analysis of its performance in ionospheric TEC predictions in support of GPS positioning and navigation. It investigated ionospheric TEC predictions using Dual frequency technique and TEC map using Bernese software (BGS) with PPP technique. For TEC dual frequency, it assessed the errors translated from the code-delay to the carrier-phase ionospheric observable by the so-called “Levelling Process”, which was applied to reduce carrier-phase ambiguities from the data. The TEC data derived from GPS pseudorange measurements have a large uncertainty because the pseudorange has high noise level. In contrast, the noise level of carrier phase measurements is significantly lower than the pseudorange ones. To reduce the effect of pseudorange noise on TEC data, GPS pseudorange data can be smoothed by carrier phase measurements, for example, by using carrier phase smoothing technique, which is also often referred to as carrier phase levelling. Whereas, for TEC Map technique, GPS measurements from stations at the Equatorial region were used for producing maps. The Matlab and Bernese GPS software was used to derive TEC from GPS data.
\n\t\t\tThis chapter describes the parameter of the ionosphere that produces most of the effects on GPS signal which is the TEC. TEC is measured to estimate the impact of ionosphere to the signal transmitted by GPS satellite to the receiver on Earth. It is a measure of the total amount of electrons along a particular Line of sight (LOS). Ionospheric delay correction is carried out through modelling the TEC along each satellite signal path due to high spatial variability of the ionosphere. Prediction of communication failures and radio interference additionally requires accurate information on TEC variations. Another technique to calculate TEC is by using Code’s IGS TEC Map. It is based on spherical harmonic expansion parameterizations and computed based on the BGS Software and the output is in standard IONEX.
\n\t\tThe TEC is defined as the total number of electrons integrated along the path from the receiver to each GPS. The TEC as an indicator of ionospheric variability that derived by the modified GPS signal through free electrons. TEC is measured in units of 1016 electrons meter per square area, where 1016 electrons/m² = 1 TEC unit (TECU) (Abdullah, 2009).
\n\t\t\tThe nominal range is 1016 to 1019 with minima and maxima occurring at midnight and mid afternoon approximately. At night the TEC decays rather slowly due to recombination of electrons and ions. Maximum TEC usually occurs in the early afternoon and minimum TEC usually occurs just before sunrise. Also daily TEC variations increase as one travels from north to south, as sunlight is more direct.
\n\t\t\tThere are several methods to obtain the TEC over the reference station. In this work TEC was obtained from dual frequency method and the IGS (International GPS Service) TEC map.
\n\t\t\tTEC is significant in determining scintillation and group delay of a radio wave through a medium. Ionospheric TEC is characterized by observing carrier phase delays of received radio signals transmitted from satellites located above the ionosphere, often using GPS satellites. GPS satellites transmit electromagnetic waves for positioning on two frequencies which is L1 (1575.42 MHz) and L2 (1227.60 MHz) allowing receivers equipped with dual frequency operation to be used. This enables us to extract the ionosphere TEC along the line of sight, from satellite to receiver.
\n\t\t\t\tIn this work, the TEC is observed at the F layer because this region has the highest variability of free electrons, causing the greatest effect on GPS received signal compared to other layers. More than two-third of electron concentration are located at F2 layer. This method is conducted by going through several processes. Figure 2 shows the flow chart of work progress to achieve the objective of the project.
\n\t\t\t\tFlow chart of TEC processing.
The process of extracting data from RINEX (Receiver Independent Exchange) file was done by using Matlab programming language whereby the RINEX file was obtained from the GPS receiver as shown in figure 3. The program will analyse and extract the information needed in calculating the TEC from the observation and navigation RINEX file. The result will show the graph of elevation angle, different phase, different delay, slant TEC (TECs) and vertical TEC (TECv) versus time. This data of TECv were used since its value is not depending on the location of satellite receiver compared to TECs.
\n\t\t\t\tFlowchart of TEC processing.
Dual-frequency carrier phase and code-delay GPS observations are combined to obtain ionospheric observables related to the (TECs) along the satellite-receiver line of sight (LOS). Pseudorange is applicable to P(Y)-codes and C/A-codes. The pseudorange equation in units of length can be expressed as:
\n\t\t\t\t\tWhere\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
Carrier phase is the measurement of the phase difference between the carrier signal generated by the receiver’s internal oscillator and the carrier signal transmitted from a satellite. The basic equation for the carrier phase measurement is:
\n\t\t\t\t\tWhere \n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
The true range or geometric range can be represented by:
\n\t\t\t\t\tWhere
Dual band GPS receivers were considered in the measurable linear combination (LC). Dual frequency observations can be used to measure the ionosphere delay. This delay can then be removed from the measurements by combining the frequencies,
Where\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
The integrated TEC from the receiver to the satellite is proportional to the accumulated effect by the time the signal arrives at the receiver. This affects the GPS range observables: a delay is added to the code measurements and advance to the phase measurements. To achieve very precise positions from GPS, this ionospheric delay or advance must be taken into account. A GPS operates on two different frequencies
A dual-frequency GPS receiver can measure the difference in ionospheric delays between the L1 and L2 of the GPS frequencies, which are generally assumed to travel along the same path through the ionosphere. Thus, the group delay can be obtained as:
\n\t\t\t\t\tWhere
The TEC can also be obtained by writing Eq. (6) as
\n\t\t\t\t\tif dual frequency receiver measurements are available;
\n\t\t\t\t\twhere (
TEC can be divided into two parts. There are:
\n\t\t\t\t\tSlant TEC (TECs)
Vertical TEC (TECv)
Slant TEC is a measure of the total electron content of the ionosphere along the ray path from the satellite to the receiver, represented in figure 4. Although TECs is measured at differing elevation angles, usually the TECv is modelled. TECv enables TEC to be mapped across the surface of the Earth.
\n\t\t\t\t\tTEC measurements are taken from different GPS satellite observed at arbitrary elevation angles. This causes the GPS signals to cross largely different portion of the ionosphere. To compare the electron contents for paths with different elevation angles, the TECs must be transformed into equivalent vertical content or TECv by dividing it by the secant of the elevation angle at a mean ionospheric height, which usually taken to be between 350 and 450 km. Generally by referring to figure 4, the slant TEC, TECs through a given sub-ionospheric point is obtained from Eq. (8).
\n\t\t\t\tPrecision monitoring of ionosphere will have profound implications in almost all areas of GPS user communities. The ionospheric mapping function is one of the first assumptions to consider typically when ionospheric corrections are estimated or applied from Global Navigation Satellite System (GNSS) data. The typical assumption in many GNSS imaging and navigation systems is to consider a fixed mapping function constant, and associated to a 2D distribution of electron content at a given effective height (typically some value between 300 and 500 km).
\n\t\t\t\t\tThe line-of-sight TEC values were converted to TECv values using a simple mapping function and were associated to an ionospheric pierce point (IPP) latitude and longitude, assuming the ionosphere to be compressed into a thin shell at the peak ionospheric height of 350 km as illustrated in figure 4. The thin shell model was used and its height is the effective height which is taken as the ionospheric pierce point altitude. Generally, the ionosphere can be divided into several layers in altitude according to electron density, which reaches its peak value at about 350 km in altitude.
\n\t\t\t\t\tIonospheric Single Model (SLM).
Source:
The thin layer model currently used in GPS has deficiencies resulting from conversion of slant TEC to effective vertical TEC. The deficiencies come from in appropriate attribution of the thin shell height. This conversion introduces a few errors in the middle latitude where electron density is small. But it many result in obvious error at low latitude with large electron density and great gradient (Horvath, 2000). Usually, the ionospheric delay resulting from observation noises, less than 1 TECU, is omitted. It is assumed that, in the two-dimensional spherical shell model, the majority of electron density is concentrated in a thin layer with a height of 350-450 km above the surface of the Earth.
\n\t\t\t\t\tGenerally by referring to figure 4, TECs through a given sub-ionospheric point is obtained from Eq. (8)\n\t\t\t\t\t
\n\t\t\t\t\tWhere TECs is the value of slant TEC,
In some literature this is called the elevation-dependent single layer (or thin shell) model mapping function, SLM where can be written as
\n\t\t\t\t\tWhere \n\t\t\t\t\t\t
\n\t\t\t\t\t\t
where α is correction factor which is close to unity. The value is chosen to be 0.9782 when using
\n\t\t\t\t\t\t
GPS signals can be used to extract ionospheric parameters such as TEC. For single frequency GPS users, models of the ionosphere such as the Klobuchar model (Klobuchar, 1987), which is also known as the GPS broadcast model, have been constructed utilizing ionospheric parameters given in the GPS broadcast message. It is represented by a third degree polynomial where the coefficients of the polynomial are transmitted as part of the broadcast message header. The TEC can also be obtained as in Eq. (7), if dual frequency receiver measurements are available. As the TEC between the satellite and the user depends on the satellite elevation angle, this measurement is called TECs. The TEC varies with times and over the space, and it depends on the solar activity, user location and the PRN elevation angle.
\n\t\t\t\t\tIn practice, calculation of TEC by the above means, using pseudorange data only, can produce a noisy result. It is desirable to also use the relative phase delay between the two carrier frequencies in order to obtain a more precise result. Differential carrier phase gives a precise measure of relative TEC variations but because the actual number of cycles of phase is not known, absolute TEC cannot be found unless pseudorange is also used. Pseudorange gives the absolute scale for TEC while differential phase increases measurement precision. The TEC data derived from GPS pseudorange measurements have a large uncertainty because the pseudorange has high noise level. In contrast, the noise level of carrier phase measurements is significantly lower than the pseudorange ones. To reduce the effect of pseudorange noise on TEC data, GPS pseudorange data can be smoothed by carrier phase measurements. For example is by using carrier phase smoothing technique, which is also often referred to as carrier phase levelling. Carrier phase levelling or phase smoothing is essentially some combination of the noisy code pseudorange with the comparatively smooth varying carrier phase. The carrier phase contains much smaller measurement error than pseudoranges, so that ionospheric TECs can be obtained by carrier phase smoothing the pseudoranges (Hansen et al., 2000). This was done as shown below:
\n\t\t\t\t\tFirstly, the phase observations, measured in cycles, are scaled to units of length by multiplying with the wavelength. Because the phase measurements are ambiguous, so the phase derived slant delay, obtained from geometry free linear combination, L4 calculated from Eq. (12) was scaled to zero relative range error at the first epoch. This eliminates the integer ambiguity provided there are no cycle slips.
\n\t\t\t\t\tTo eliminate the code multipath effect that is normally seen at both ends of the path or at low elevation angles, the code differential delay was fitted at the higher elevation angles. This was done by defining a shift value and was added to the relative phase to fit the code differential delay. This results in the absolute differential delay and the remaining noise was discarded.
\n\t\t\t\t\t\n\t\t\t\t\t\tFigure 5 shows the differential delays determined using the above procedure. This smoothed differential delay (with less noise and multipath) was then translated to the absolute TECs by multiplying with a constant (see Eq. (7)). A mapping function, SLM is used together with Eq. (8) to convert TEC to the vertical from the slant value. For a good description on the determination of absolute TEC from dual frequency GPS measurements refer to Parkinson and Spilker (1996).¸
\n\t\t\t\t\tPhase smoothed code differential delay.
Bernese GPS Software (BGS) was used to map the ionosphere in this work. BGS is commonly used by scientists for research and education, survey agencies responsible for high-accuracy GNSS surveys, agencies responsible for maintaining arrays of permanent GPS receiver and also commercial users with complex applications demanding high accuracy, reliability and high productivity (Dach, 2007). TEC map has gained much attention in the recent years because of the ionospheric effects to the GPS-based navigation application. A range delay caused by the ionosphere during quiet and disturbed geomagnetic days can be approximated using the measurements of TEC map.
\n\t\t\t\tTEC ionopheric values and maps can be delivered by the International GPS Service (IGS). IGS has developed the global ionospheric gridded data representing the TEC over the whole globe. Analysis centres deliver their results of TECv and DCBs in the IONosphere Exchange (IONEX) format (Schaer et al., 1998).
\n\t\t\t\tIn this new version of BGS, PPP was processed using BPE. BPE consists of data, user scripts and four process control file (PCF) where one of the PCF is PPP. PCF in PPP mode has been selected to run PPP. In this PPP.PCF, regional ionosphere model is generated and stored in Bernese ionosphere file and in IONEX file using GPS Estimation (GPSEST) program. GPSEST is the program that able to generate TEC maps in IONEX (Schaer et al., 1998). GPSEST program is used to model and estimate the ionosphere. In GPSEST program, geometry-free linear combination from the zero-difference code observations was used because it principally contains ionospheric information. Geometry-free linear combination of this un-differenced GPS observations is then applied in GPSEST to generate TEC map.
\n\t\t\t\tA MSLM was used for mapping the TEC, approximated by a spherical layer with infinitesimal thickness assuming that all free electrons are concentrated in altitude,
This proved that PPP technique can be used to determine TEC over single station in Malaysia. With the new BGS version 5.0; PPP technique is now available to produce ionosphere maps. PPP is known as a valuable tool to provide an accurate position anywhere on Earth, also for investigating many geophysical processes at the millimetre level.
\n\t\t\tThe ionosphere GPS-TEC measurements were carried out using GPS receiver networks from Department of Survey and Mapping, JUPEM. GPS data on 8 November 2005 were analyzed for this initial analysis. The stations were at Wisma Tanah, Kuala Lumpur, (3˚ 10’ 15.44”N; 101˚ 43’ 03.35”E) KTPK station and Universiti Teknologi Malaysia, Johor (1˚33’ 56.934”N, 103˚38’22.429”E), UTMJ station as shown in figure 6. This analysis was based on one hour observations from 5:00 – 6:00 UT (13-14 PM (LT)) using GPS satellite PRN 23 for KTPK station and also using GPS satellite PRN 23 for UTMJ station. The GPS data was recorded in universal time (UT) system. The sampling time interval is 15 second and the cut-off elevation mask is 15 . GPS data used in this project were recorded on a quiet geomagnetic day where the geomagnetic index Kp is 1.
\n\t\t\tMASS stations in Malaysia.
Source:
\n\t\t\t\t\tFigure 7 to 11 show representative cases of the different situations found in the analysis. The absolute slant TEC from the KTPK station and UTMJ station can be measured directly from this dual frequency method. This can be calculated by using pseudorange and carrier phase measurements from the satellites (e.g. PRN 23) used in this study. Figure 7 (a and b) shows the elevation angle of GPS satellite PRN 23 at 5:00 – 6:00 (UT) for KTPK Station and 5:00 - 6:00 (UT) for UTMJ station. The elevation angle can be calculated from the GPS navigation data (or ephemeris). The elevation angle for KTPK and UTMJ station can be illustrated as below:
\n\t\t\t\ta) Elevation angle of GPS Satellite PRN 23, 5:00-6:00 (UT) (KTPK station), (b) Elevation angle of GPS Satellite PRN 23, 5:00-6:00 (UT) (UTMJ station).
\n\t\t\t\t\tFigure 8 (a and b) clearly indicate the code TEC and phase TEC of PRN 23 for elevation from 74˚ to 51˚ and 71˚ to 52˚. The differential delay (=P2-C1) from code measurements is noisy and influenced by multipath while the phase measurements, are ambiguous and less effected by the multipath, were used to smooth the code differential delay. Then the vertical TEC can be obtained. This eliminates the integer ambiguity provided there are no cycle slips.
\n\t\t\t\ta) Different phase (L1-L2) before scale to different code (P2-C1) for GPS Satellite PRN 23, 5:00-6:00 (UT) (KTPK station), (b) Different phase (L1-L2) before scale to different code (P2-C1) for GPS Satellite PRN 23, 5:00-6:00 (UT) (UTMJ station).
a) Relative range error computed from the differential carrier phase advance for GPS Satellite PRN 23, 5:00-6:00 UT (KTPK station), (b) Relative range error computed from the differential carrier phase advance for GPS Satellite PRN 23, 5:00-6:00 UT (UTMJ station).
Shown in figure 9 (a and b) are the absolute ionospheric range error obtained from differential group delay. At this stage, levelling process was applied to eliminate the code multipath effect especially at low elevation angles. This was done by defining a shift value and adding it to the relative phase to fit the code differential delay. For the levelling process, it assumed the average at the elevation angle (± 60 -90 ) as reference and it can be seen in figure 7. This value was chosen because there is no multipath at the high elevation angle and during low elevation angle multipath where it can still be seen. After the differential carrier phase was converted to an absolute scale by fitting it to the differential group delay curve over the desirable, low multipath portion of each pass, the differential group delay data were simply discarded.
\n\t\t\t\ta) TEC slant scale to (P2- C1) TECU for PRN 23, 5:00-6:00 UT (KTPK station), (b) TEC slant scale to (P2- C1) TECU for PRN 23, 5:00-6:00 UT (UTMJ station).
This smoothed differential delay (with less noise and multipath) was then translated to the absolute slant TEC by multiplying it by a constant Eq. (7) as shown in figure 10 while figure 11 shows TEC vertical for GPS satellite PRN 23 for KTPK and PRN 23 for UTMJ station.
\n\t\t\t\ta) TEC SLM, TEC M-SLM, GPS Satellite PRN 23, 5:00-6:00 UT (KTPK station), (b) TEC SLM, TEC M-SLM, GPS Satellite PRN 23, 5:00-6:00 UT (UTMJ station).
\n\t\t\t\t\tFigure 11 shows that SLM was used to convert the slant TEC to vertical TEC. The analysis at an equatorial region used SLM mapping function. The peak altitude ranges from 350 to 500 km at equatorial latitudes. However, from the figure it also shows that the MSLM which is TEC for SLM is small compared to MSLM. The vertical TEC values are precise, accurate and without multipath, unless the multipath environment is really terrible, in which case a small, residual amount of multipath can even be seen in the differential carrier phase.
\n\t\t\tTEC Map is computed with the BGS software using the PPP program and the output is in standard IONEX format. A MSLM was used for mapping the TEC, approximated by a spherical layer with infinitesimal thickness assuming that all free electrons are concentrated in altitude,
Using MSLM noted above, a vertical TEC can be obtained at IPP. It can be shown that a single GPS receiver can probe the ionosphere in a radius of 960 km assuming 10 elevation cut-off angle and 450 km height. In order to suit the geographic location to all observational epochs, region located between 0º to 7º north of geographic latitude and 90º to 110º longitude was selected. This map covers a 24 hour time period at intervals of 2 hours starting from 00.00.00 hour.
\n\t\t\t\t\n\t\t\t\t\tFigure 12 illustrates the longitudinal vertical TEC map for KTPK station on 8 November 2005 produced with PPP technique with two-hour intervals between each map, starting from 00:00 to 22:00 UT where local time (LT) is +8. Based on figure 12, TEC starts increasing at 00:00 UT at about 7 TECU and gradually increased reaching a maximum level of 28 TECU at 06:00 UT (14:00 LT) then decreased steadily until nearly 20:00 UT before sunrise and rate of ion production is low. It showed that the maximum value of TECU usually happens near midday while the minimum value of TECU occurs at night. The low TEC over equatorial region is mostly due to the Kp and Dst index.
\n\t\t\t\tTEC Map for KTPK station, 8 November 2005.
A comparison was made with Global Ionosphere Maps (GIM) downloaded from Centre for Orbit Determination in Europe (CODE) as shown in figure 13. GIM from CODE was generated using data from about 150 GPS receivers around the globe. GIM used 5.0º and 2.5º in longitude and latitude of special resolution with two-hour intervals. For the comparison purpose, an area covering regional model was extracted from IGS maps. Both figures show the same pattern of longitudinal variation of TEC starting from 00:00 UT to 22:00 UT. It is noticeable however, that TEC from GIM is higher by about 0 to 5 TECU, as compared with the maps generated by PPP.
\n\t\t\t\tTEC map from IGS, 8 November 2005.
This data was 12 plotted as a 24 hour contour map as a function of longitude as illustrated in figure 12. The TEC above the reference station was extracted from interpolation of this data at every epoch (30s interval) as illustrated in figure 14.
\n\t\t\t\tTEC extracted from TEC map.
The difference between the two maximum TEC is because there was no IGS station located in Malaysia. The diurnal profile of ionospheric variation from both figure showed a good agreement. This proved that PPP technique can be used to generate TEC map over single receiver station. Figure 15 clearly indicates the 3-D maps based on IONEX data. The IONEX data have been generated from the BGS software with PPP program. The effective height obtained for 450 km (MSLM) for KTPK station with TEC is 34 TECU.
\n\t\t\t\tD MSLM for KTPK station.
The research has also identified several possibilities of GPS methodology including accuracy issues and further improvement on TEC that can be incorporated in future research. The following issues and directions have been noted:
\n\t\t\tIn this work, only two signal involve which is L1 and L2 to investigate ionospheric TEC. Further, it would be necessary to include new improved signal, which is L5 for more precise and accurate.
Utilize data taken from other satellite navigation systems such as GLONASS, Galileo, etc
More detailed work for different ionospheric condition needs to be verified and compared for other region such as high latitude, Antartic and Artic.
Implementing this suggested further work would extend the TEC measurements at any location with any ionospheric conditions. The outcome gives a different approach that could be considered also for current or future GNSS augmentation systems to overcome the ionospheric error.
\n\t\tIn this chapter we have presented methods for processing TEC which utilize different techniques. Two scenario of obtaining TEC were studied such as TEC dual frequency and TEC Map. First, for TEC Dual Frequency, GPS carrier phase derived TEC provides a smooth but relative measurement of ionospheric TEC, while code derived TEC provides a noisy but absolute measurement. To mitigate inherent fluctuations in pseudorange due to bandwidth limited precision, receiver noise, cycle slip, multipath etc, Levelling Process was applied to reduce carrier-phase ambiguities from the data. As a result, the remaining noise is discarded.
\n\t\t\tMean while for TEC Map, analysis results showed that TEC have similar variations, where the TEC values start to increase gradually from morning and reach its maximum at noon and decrease around afternoon. Bernese software, the scientific GPS software packages has already proved its ability to determine an accurate regional TEC map. The PPP technique can be used to generate the TEC map. TEC map are needed in order to characterize the ionospheric behaviour. The result proved that PPP technique can be performed at cm- level. Besides, extraction of TEC information can also be done.
\n\t\t\tConsidering the variability of the ionosphere in the equatorial region, it is recommended to analyze other mapping functions to project the line-of-sight ionosphere delay into the vertical used in the proposed approach.
\n\t\tIn the past few decades, N-heterocyclic carbenes (NHCs) open the new field of organocatalysis in synthetic organic chemistry [1]. Particularly, chiral NHCs have gained increasing attention as a powerful and versatile organocatalyst for the enantioselective synthesis of various molecules with structural diversity and complexity [2, 3, 4, 5, 6, 7]. Although a wide variety of chiral NHC precursors were developed, chiral thiazolium-derived carbenes are the most widely used catalysts for asymmetric synthesis. Based on the characteristic structures, chiral thiazolium precursors can be classified as aminoindanol-based thiazoliums, morpholine-based thiazoliums, pyrrolidine-based thiazoliums, and acyclic thiazoliums [6]. Furthermore, new methods and strategies for NHC catalysis are emerging continuously, leading to remarkable progress on cooperative catalysis using NHC/Lewis acid, NHC/Brønsted acid, and NHC/hydrogen-bonding organocatalyst [8, 9]. In recent years, cooperative catalysis has been expanded by the combination of NHCs with transition-metal catalysts or photocatalysts [10]. This chapter highlights the recent dramatic progress in the cooperative NHC catalysis with transition-metal catalysts or photocatalysts.
In recent years, the use of transition-metal catalysts in the NHC catalysis has become a widespread strategy for cooperative catalysis, although NHCs are known to act as a ligand for transition metals.
The palladium-catalyzed allylic substitutions are wildly used for achieving cooperative NHC catalysis. Initially, the successful combination of NHC catalysis with transition-metal catalysis was reported in the cascade reactions involving the addition of NHC-catalyzed product to π-allyl palladium intermediate [11, 12, 13]. In 2014, cooperative catalysis was achieved by the simultaneous activation of substrates using NHC catalyst and palladium catalyst [14]. This cooperative transformation proceeded
The palladium-catalyzed allylic substitutions are applied to the enantioselective NHC catalysis [15, 16, 17, 18, 19, 20]. The cooperative catalysis was achieved by using chiral NHC catalyst and palladium catalyst (Figure 1) [15, 16, 17]. In the presence of palladium catalyst [Pd(PPh3)4 (5 mol%)] and chiral NHC generated from NHC precursor
Enantioselective catalysis using NHC and π-allyl palladium(II) complex.
NHCs can invert the reactivity of aldehyde from electrophilic to nucleophilic by the formation of Breslow intermediate as an acyl anion equivalent from NHC catalyst and aldehyde. The cooperative NHC/palladium reactions through the nucleophilic addition of Breslow intermediate to the π-allyl palladium(II) complex were investigated (Figure 2) [21, 22, 23, 24, 25, 26]. The 2:1 coupling reaction of pyridine-2-carboxaldehyde
Cooperative catalysis based on umpolung of aldehydes.
The propargylation reaction of pyridine-2-carboxaldehyde
The cooperative NHC/palladium reaction for the umpolung 1,4-addition of aryl iodides or vinyl bromides to enals was developed [27, 28]. The combination of NHC, generated from precursor
Cooperative catalysis for umpolung 1,4-addition to cinnamaldehyde.
The cooperative catalysis using NHC and copper catalyst was investigated (Figure 4) [29, 30]. The catalytic reaction using alkyne
Cooperative catalysis with copper catalyst.
The cooperative catalysis using NHC and gold catalyst was reported (Figure 5) [31]. When NHC precursor
Cooperative catalysis with gold catalyst.
The combination of NHC catalysis and ruthenium redox catalysis was investigated [32, 33, 34]. The oxidation of the Breslow intermediate leads to the formation of α,β-unsaturated acyl azolium
Cooperative catalysis with ruthenium catalyst.
The combined use of NHC and photocatalyst has gained increasing attention as novel redox catalysis. The compatibility of NHC with ruthenium photocatalyst was demonstrated (Figure 7) [37]. Acylation of
Compatibility of NHC with ruthenium photoredox catalyst.
The cooperative catalysis was applied to the oxidative transformation of aldehydes (Figure 8) [39, 40, 41, 42]. The oxidative esterification of cinnamaldehyde
Cooperative catalysis
The cooperative catalysis for preparing ketones from carboxylic acid derivatives was studied (Figure 9) [43, 44]. The synthesis of ketone
Cooperative catalysis for preparing ketones.
In addition to the cooperative NHC catalysis with photocatalysts, the combined use of NHC catalysis and photoredox reaction in the absence of a photocatalyst has gained increasing attention as novel catalysis [45, 46, 47].
The N-heterocyclic carbenes (NHCs) are powerful and versatile organocatalysts that induce synthetically valuable chemical transformations. In addition to the cooperative catalysis using NHC/Lewis acid, NHC/Brønsted acid, and NHC/hydrogen-bonding organocatalyst, the cooperative NHC catalysis combined with transition-metal catalysts are emerging continuously. In the last few years, the combined use of NHC and photocatalyst has gained increasing attention as dual redox catalysis. The recent dramatic progress in NHC-induced cooperative catalysis disclosed a broader aspect of the utility of NHC-organocatalysis for synthetic organic chemistry. This chapter will inspire creative new contributions to organic chemists.
Our work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (C) Grant Number 16K08188.
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Magnetic materials absorb greatly microwaves. The more magnetic, the more microwaves are absorbed. The aim of this chapter is to present the fundamental physics of the absorption of microwave power (energy per unit time) by ferrimagnetic and ferromagnetic matter in the nano and micro size scale. The magnetic moments and their collective modes are the basic microscopic absorbers under in-resonance and out-of-resonance conditions. Experimental setups and measurement techniques are described. The profiles of microwave absorption are described and connected to the micromagnetic environment that elicits such absorption. Section by section and the overall microwave power absorption profiles are related to the micromagnetic structures. Emphasis is made on nano- and micromagnets. These interactions of microwaves with nano- and micromagnets serve to infer microscopic magnetic information.",book:{id:"7617",slug:"electromagnetic-fields-and-waves",title:"Electromagnetic Fields and Waves",fullTitle:"Electromagnetic Fields and Waves"},signatures:"Rafael Zamorano Ulloa, Ma. Guadalupe Hernandez Santiago\nand Veronica L. Villegas Rueda",authors:[{id:"176210",title:"Dr.",name:"Rafael",middleName:null,surname:"Zamorano Ulloa",slug:"rafael-zamorano-ulloa",fullName:"Rafael Zamorano Ulloa"},{id:"289450",title:"Mrs.",name:"María G.",middleName:null,surname:"Hernández",slug:"maria-g.-hernandez",fullName:"María G. Hernández"},{id:"289451",title:"Ms.",name:"Verónica L.",middleName:null,surname:"Villegas",slug:"veronica-l.-villegas",fullName:"Verónica L. 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The radiofrequency electromagnetic waves (RFW) emitted by different smart phones was measured by using a TriField meter. Chick fertilized eggs were placed in an egg incubator, divided into control and exposed groups. In the exposed group, a mobile phone was placed inside an incubator in call receiving mode, while in the control group, the mobile phone was not used. Studies were conducted at low and high exposure (dose) of RFW. Chick embryos were sacrificed at day 10 and day 15, and embryos were examined for mortality, gross malformation, weight, and length. Histology, electron microscopy, and Hsp 70 of liver were done for the high dose group. No mortality was observed in the low dose group; however, in the high dose group, the mortality was 14%, and deformities of the limbs and skin abnormalities were observed. Weight and length in the exposed groups were significantly lower than the control at higher dose. Histology and ultrastructure of liver revealed fatty infiltration, increase number of mitochondria, deformation, and disappearance of its cristae. Hsp 70 and mRNA levels were elevated in the exposed groups for high dose group.",book:{id:"7617",slug:"electromagnetic-fields-and-waves",title:"Electromagnetic Fields and Waves",fullTitle:"Electromagnetic Fields and Waves"},signatures:"Najam Siddiqi and Nasser Al Nazwani",authors:[{id:"278673",title:"Dr.",name:"Najam",middleName:null,surname:"Siddiqi",slug:"najam-siddiqi",fullName:"Najam Siddiqi"},{id:"291777",title:"Prof.",name:"Nasser",middleName:null,surname:"Al Nazwani",slug:"nasser-al-nazwani",fullName:"Nasser Al Nazwani"}]},{id:"16084",title:"Propagation of Electromagnetic Waves in Thin Dielectric and Metallic Films",slug:"propagation-of-electromagnetic-waves-in-thin-dielectric-and-metallic-films",totalDownloads:5903,totalCrossrefCites:0,totalDimensionsCites:1,abstract:null,book:{id:"166",slug:"electromagnetic-waves",title:"Electromagnetic Waves",fullTitle:"Electromagnetic Waves"},signatures:"Luc Levesque",authors:[{id:"26483",title:"Dr.",name:"Luc",middleName:"Joseph",surname:"Lévesque",slug:"luc-levesque",fullName:"Luc Lévesque"}]}],onlineFirstChaptersFilter:{topicId:"737",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81875",title:"Terahertz Conductivity of Nanoscale Materials and Systems",slug:"terahertz-conductivity-of-nanoscale-materials-and-systems",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.104797",abstract:"The history of RF technology can provide human beings a powerful lesson that the infrastructure of modern-day wireless communication depends on the complexity and configurability of silicon-based solid-state devices and integrated circuits. The field of THz technology is undergoing a developmental revolution which is at an inflection point and will bridge the ‘technology’ and ‘application’ gap in meaningful ways. This quantitative progress is a result of continuous and concerted efforts in a wide range of areas including solid-state devices, 2D materials, heterogeneous integration, nanofabrication and system packaging. In this chapter, the innovative theoretical approaches that have enabled significant advancement in the field of system-level THz technology are discussed. The focus is kept on the formulation of terahertz conductivity which plays a critical role in the modeling of devices that integrate technologies across electronics and photonics. Further, the findings build on coupling a probe pulse of terahertz illumination into the photoexcited region of amorphous silicon are presented and discussed in detail. Terahertz light has a higher penetration depth for opaque semiconductor materials which provides an accurate method to measure the conductivity of novel materials for the construction of efficient solar cells. This paves the way for the possibility to develop energy systems can address the need for reconfigurability, adaptability and scalability beyond the classical metrics.",book:{id:"10206",title:"Terahertz Technology",coverURL:"https://cdn.intechopen.com/books/images_new/10206.jpg"},signatures:"Rahul Goyal and Akash Tiwari"},{id:"80442",title:"Interdigitated Photoconductive Antenna for Efficient Terahertz Generation and Detection",slug:"interdigitated-photoconductive-antenna-for-efficient-terahertz-generation-and-detection",totalDownloads:85,totalDimensionsCites:0,doi:"10.5772/intechopen.102379",abstract:"THz signals can be generated commonly from Photoconductive Antenna (PCA) but the efficiency is low for the conventional PCA. This work improves the optical to terahertz conversion efficiency of the terahertz radiation by changing the conventional PCA structure to Interdigitated PCA (IPCA). The efficiency of PCA is dependent on the current pulse generated in the antenna structure when the laser pulse is incident on it. This paper targets to achieve high photo-current, as well as THz electric field from the IPCAs which are simulated using FEM and FDTD techniques. Also, the effect of various parameters such as current, gain, frequency bandwidth, optical to terahertz conversion efficiency, etc. are studied to study the importance of IPCAs.",book:{id:"10206",title:"Terahertz Technology",coverURL:"https://cdn.intechopen.com/books/images_new/10206.jpg"},signatures:"Shyamal Mondal, Nisha Flora Boby Edwin and Vaisshale Rathinasamy"},{id:"80114",title:"Terahertz Sensing Based on Photonic Crystal Fibers",slug:"terahertz-sensing-based-on-photonic-crystal-fibers",totalDownloads:112,totalDimensionsCites:0,doi:"10.5772/intechopen.101732",abstract:"Photonic-crystal-fiber (PCF) based sensors in the terahertz spectrum have been immensely studied and implemented due to their unique advantages and high sensitivity. At an early stage, conventional and hybrid structured porous core PCF-based sensors were proposed, but the sensitivity was not so high. With the advancement of PCF fabrication technology, hybrid structured hollow-core PCFs have been reported and offer superior sensing characteristics than the previous types. In this chapter, both porous core and hollow-core PCF-based THz sensors are analyzed and the propagation characteristics are explained using terahertz spectrum. Finally, some promising terahertz sensors are studied and compared at the end of this chapter.",book:{id:"10206",title:"Terahertz Technology",coverURL:"https://cdn.intechopen.com/books/images_new/10206.jpg"},signatures:"Md. Ahasan Habib, Md. Shamim Anower and Md. Nazmul Islam"},{id:"79181",title:"Terahertz Nano-Imaging with s-SNOM",slug:"terahertz-nano-imaging-with-s-snom",totalDownloads:156,totalDimensionsCites:1,doi:"10.5772/intechopen.99102",abstract:"Spectroscopy and imaging with terahertz radiation propagating in free space suffer from the poor spatial resolution which is a consequence of the comparatively large wavelength of the radiation (300 μm at 1 THz in vacuum) in combination with the Abbe diffraction limit of focusing. A way to overcome this limitation is the application of near-field techniques. In this chapter, we focus on one of them, scattering-type Scanning Near-field Optical Microscopy (s-SNOM) which − due to its versatility − has come to prominence in recent years. This technique enables a spatial resolution on the sub-100-nm length scale independent of the wavelength. We provide an overview of the state-of-the-art of this imaging and spectroscopy modality, and describe a few selected application examples in more detail.",book:{id:"10206",title:"Terahertz Technology",coverURL:"https://cdn.intechopen.com/books/images_new/10206.jpg"},signatures:"Matthias M. Wiecha, Amin Soltani and Hartmut G. Roskos"},{id:"77821",title:"Optical Heterodyne Measurement of Terahertz Wave",slug:"optical-heterodyne-measurement-of-terahertz-wave",totalDownloads:144,totalDimensionsCites:0,doi:"10.5772/intechopen.99168",abstract:"One of the most notable frequency regions in terms of research currently lies in the ‘frequency gap’ region between microwaves and infrared: terahertz wave. Although new methods for generating and detecting terahertz wave have been developed, few detectors operating at room temperature are able to capture low-energy terahertz beams. Here we introduce the optical heterodyne measurement (nonlinear frequency up-conversion detection) of terahertz wave using parametric wavelength conversion in a nonlinear crystal; this has better sensitivity than many commonly used thermal detectors such as pyroelectric detectors. Additionally, optical heterodyne techniques allow the beams of terahertz wave to be visualized and their frequency and intensity determined directly as visible light. These are very promising for extending applied researches into the terahertz region, and we expect that these will open new research fields such as wireless information communications or non-destructive inspection in the terahertz region.",book:{id:"10206",title:"Terahertz Technology",coverURL:"https://cdn.intechopen.com/books/images_new/10206.jpg"},signatures:"Shin’ichiro Hayashi and Norihiko Sekine"},{id:"77432",title:"A Novel Approach for Room-Temperature Intersubband Transition in GaN HEMT for Terahertz Applications",slug:"a-novel-approach-for-room-temperature-intersubband-transition-in-gan-hemt-for-terahertz-applications",totalDownloads:154,totalDimensionsCites:1,doi:"10.5772/intechopen.98435",abstract:"Terahertz (THz) technology has attracted tremendous attention recently due to its promising applications in various domains such as medical, biological, industrial imaging, broadband, safety, communication, radar, space science, and so on. Due to non-availability of powerful sources and highly sensitive and efficient detectors, the so-called THz gap remains largely unfilled. Despite seamless efforts from electronics and photonics technology researchers, the desired level of technology development to fill the THz gap still remains a challenge. GaN-based HEMT structures have been investigated as potential THz sources and detectors by a number of researchers. This chapter presents a very new and versatile mechanism for electrical tuning of intersubband transitions (ISBT) GaN high electron mobility transition (HEMT) devices. ISBT phenomena are usually demonstrated in photonic devices like a quantum cascade laser (QCL). Here we explore ISBT in an electronic GaN HEMT device. Conventional photonic devices like a QCL are operated at cryogenic temperature to minimize thermal effect. Tuning the conduction band through external gate bias is an advantage of an HEMT device for room temperature (RT) THz applications. This chapter demonstrates the theoretical and experimental novel ISBT phenomenon in GaN HEMT is for potential ambient applications in the THz range.",book:{id:"10206",title:"Terahertz Technology",coverURL:"https://cdn.intechopen.com/books/images_new/10206.jpg"},signatures:"Rakesh Kaneriya, Gunjan Rastogi, Palash Basu, Rajesh Upadhyay and Apurba Bhattacharya"}],onlineFirstChaptersTotal:9},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:42,paginationItems:[{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82440",title:"Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease",doi:"10.5772/intechopen.105746",signatures:"Mohan Vanditha, Sonu Das and Mathew John",slug:"lipid-metabolism-and-associated-molecular-signaling-events-in-autoimmune-disease",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82483",title:"Oxidative Stress in Cardiovascular Diseases",doi:"10.5772/intechopen.105891",signatures:"Laura Mourino-Alvarez, Tamara Sastre-Oliva, Nerea Corbacho-Alonso and Maria G. 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She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:{name:"Kobe College",institutionURL:null,country:{name:"Japan"}}}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. 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He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. 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He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. 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I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. 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Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. 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He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). 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Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. 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His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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To tackle global challenges of development and environment, the United Nations General Assembly in 2015 adopted the 17 Sustainable Development Goals. SDGs emphasize that environmental sustainability should be strongly linked to socio-economic development, which should be decoupled from escalating resource use and environmental degradation for the purpose of reducing environmental stress, enhancing human welfare, and improving regional equity. Moreover, sustainable development seeks a balance between human development and decrease in ecological/environmental marginal benefits. Under the increasing stress of climate change, many environmental problems have emerged causing severe impacts at both global and local scales, driving ecosystem service reduction and biodiversity loss. Humanity’s relationship with resource exploitation and environment protection is a major global concern, as new threats to human and environmental security emerge in the Anthropocene. 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