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These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
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\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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Confirmation of diagnosis of Parkinson's disease thus remains a difficulty. This book brings forth an update of most recent developments made in terms of biomarkers and various imaging techniques with potential use for diagnosing Parkinson's disease. A detailed discussion about the differential diagnosis of Parkinson's disease also follows as Parkinson's disease may be difficult to differentiate from other mimicking conditions at times. As Parkinson's disease affects many systems of human body, a multimodality treatment of this condition is necessary to improve the quality of life of patients. This book provides detailed information on the currently available variety of treatments for Parkinson's disease including pharmacotherapy, physical therapy and surgical treatments of Parkinson's disease. Postoperative care of patients of Parkinson's disease has also been discussed in an organized manner in this text. Clinicians dealing with day to day problems caused by Parkinson's disease as well as other healthcare workers can use beneficial treatment outlines provided in this book.",isbn:null,printIsbn:"978-953-307-465-8",pdfIsbn:"978-953-51-6501-9",doi:"10.5772/952",price:119,priceEur:129,priceUsd:155,slug:"diagnosis-and-treatment-of-parkinson-s-disease",numberOfPages:276,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"ead2d09d678e2b48f9c6f072ddf1f4b3",bookSignature:"Abdul Qayyum Rana",publishedDate:"September 22nd 2011",coverURL:"https://cdn.intechopen.com/books/images_new/435.jpg",numberOfDownloads:48562,numberOfWosCitations:10,numberOfCrossrefCitations:7,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:18,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:35,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 14th 2010",dateEndSecondStepPublish:"November 11th 2010",dateEndThirdStepPublish:"March 18th 2011",dateEndFourthStepPublish:"April 17th 2011",dateEndFifthStepPublish:"June 16th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"32584",title:"Dr.",name:"Abdul Qayyum",middleName:null,surname:"Rana, Md, Frcpc, Frcp (hon)",slug:"abdul-qayyum-rana-md-frcpc-frcp-(hon)",fullName:"Abdul Qayyum Rana, Md, Frcpc, Frcp (hon)",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:'Dr. Abdul Qayyum Rana is a Canadian neurologist who specializes in the field of Parkinson’s disease and Movement Disorders. He is a fellow of the Royal College of Physicians and Surgeons of Canada. After completing his neurology residency training, Dr. Rana undertook a clinical fellowship in Parkinson’s disease and Movement Disorders at the University of Ottawa, Canada. He is currently the director of the Parkinson’s Clinic of Eastern Toronto and Movement Disorders Centre located in Toronto, Canada. He is also founder of World Parkinson’s Program. He is the author of “Frequently Asked Questions About Parkinson’s Disease”, which is a series of thirteen brochures about Parkinson’s disease, translated in many languages and used in several countries around the world. 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and combustion chambers and accounts for 90–98% of the total heat transfer in steam boiler fireboxes [1, 2, 3].
Since the late nineteenth century and throughout the twentieth century, heat transfer in torch furnaces, fireboxes, and combustion chambers was calculated based on the law that was experimentally established by Stefan in 1879 in studying radiation from solid bodies, which was then theoretically substantiated by Boltzmann in 1884. In the late nineteenth to the early twentieth century, solid lumped fuel (coal, peat, and wood) was fired in furnaces on fire grates, and the first descriptions of heat transfer processes were essentially descriptions of problems and calculation of radiant heat transfer between two arbitrarily located surfaces (a fuel bed and a heating surface) on the basis of Stefan-Boltzmann’s law. In 1924, Kirpichev gave an analysis of methods for solving this problem that had been developed by different researchers [4], and Stefan-Boltzmann’s law is presently formulated as follows:
where q is the density of heat flux radiated from the fuel to the heating surface (W/m2), cs is the black body emissivity factor (W/(m2 K4)), εred is the reduced emissivity, Т1 and Т2 are the temperatures of fuel bed and heating surface (K), and φ12 is the view factor for radiation from the fuel bed on the heating surface.
In the twentieth to the twenty-first centuries, flaring of gas, liquid, pulverized fuel in furnaces, fire boxes, and combustion chambers was widespread. Fuel flaring is characterized by volume emission, a three-dimensional radiation model [1, 2, 3, 4, 5, 6]. In torch, gas volume emits 1015–1030 particles of atoms. Radiation of each particle and atom on the calculated area should be considered. The calculation of heat radiation on the calculated area of all the atoms in the gas volume and the torch requires the solution of triple integral equations [7, 8, 9, 10]. The solution of triple integral equations to determine the average path length of beams from the emitting particles, atoms, and angular radiation coefficients of the gas volume on the calculated area in the twentieth to the twenty-first centuries has not been found [7, 8]. The laws of radiation from gas volumes were not disclosed.
It is considered that the problem of calculating heat transfer in torch furnaces, fireboxes, and combustion chambers was solved with the appearance of computers and the use of numerical simulations of integral equations of heat transfer [11, 12]. However, long-term analytical and experimental studies of heat transfer have shown that the results of the numerical solution of integral equations of heat transfer on computers are not valid [9]. The method uses the laws of heat radiation of a blackbody, solid bodies, and Stefan-Boltzmann law (1); however, gas volume radiation is not subject to the laws of Stefan-Boltzmann [9, 10]. This method uses the Stefan-Boltzmann law and a large mass of approximate values of the temperatures and optic coefficients of surface and volume zones, and the accuracy of calculations is 40–80% [9, 10, 11, 12, 13].
Paradoxical cases are observed using the existing calculation methods. The torch power can be increased by additionally heating the air supplied to the burner. For example, with air heated from 20 to 600°C, the torch power increased by 17%, and its temperature rose from 1300 to 2000°C, i.e., by a factor of 1.5 [14]. According to expression (1), the density of heat flux radiated from the torch to the calculated zone should increase by a factor of 5, and the heating rate of articles being processed should also increase by a factor of 5, which is in contradiction with the energy conservation law. Under the real conditions of heating furnace operation, with air subjected to preheating and with the torch power increased by 17%, the heat flux density and the heating rate increase by 12–15%, i.e., in direct proportion to the growth of torch power and not to the fourth power of temperature [14].
In the twentieth century, the torches and emitting gas volumes remained a “black box” despite the applied enormous intellectual resources to solve the problem. Formulas for determining the main parameters of heat radiation from gas volumes, torches, formulas for determination average beam path length from quadrillions of radiating atoms, and the local angular coefficients of radiation from radiation flux densities on the calculated area were not available. The solution to the problem has stalled.
At the end of the twentieth century, in 1996–2001 the laws of heat radiation from gas volumes [13, 15, 16] and the laws of heat radiation from gas isothermal isochoric concentric spherical (Figure 1) and coaxial cylinder gas volumes (Figure 2) were dislosed, the volumes, that the torches, gas volumes of the furnaces, fireboxes, and combustion chambers are currently modeled by [17, 18, 19].
The radiation from isothermal isochoric concentric spherical gas volumes on the calculated area dF.
The radiation from isothermal isochoric coaxial cylinder gas volumes on the calculated area dF.
The laws are called Makarov’s laws with the goal of adherence to the age-old scientific traditions and copyright [13]. Based on the scientific discovery, geometric, physical, and mathematical models of gas volume and torch as a source of heat radiation have been developed. In the gas volumes formed during flare combustion of the fuel, spherical or cylindrical gas volumes are inscribed. Radiating gas atoms are simulated by emitting quadrillions of spheres, uniformly filling the spherical and cylindrical gas volumes.
The statement of the scientific disclosure is as follows. “The average path length of beams from quadrillions of radiating particles of each isochoric isothermal concentric spherical or coaxial cylindrical gas volumes to the calculated area is equal to the arithmetic mean distance from the symmetry axis of volumes to the calculated area and the angular coefficients, flux densities of radiation from gas volumes on the calculated area are equal. The flux density of radiation from the central spherical or central cylindrical gas volume of a small diameter on the calculated area is equal to the sum of the fluxes of the radiation fluxes from all the concentric spherical or coaxial cylindrical volumes on the calculated area at the radiation power released in the volume of a small diameter, equal to the sum of the radiated powers released in all spherical or coaxial cylindrical gas volumes radiating on the calculated area.
The density of the heat flux incident from the cylindrical or spherical gas volumes to the calculation area is directly proportional to the power, the local angular emission factor of the gas volume to the calculation area and inversely proportional to the absorption coefficient of the gas medium, the average path length of the rays from the emitting particles of the gas volume to the calculation area and the area of calculation area.”
Mathematical notation of the laws is as follows:
where l1, l2, l3, and li are the average beam path lengths from the first to the ith cylindrical or spherical gas volumes to the calculated area dF and l is the arithmetic mean distance from the axis of symmetry of the cylindrical volumes or the center of symmetry of the spherical volumes to the calculated area dF:
where
where
where
where
Mathematical notation of the laws of heat radiation from gas volumes and the laws of Makarov is obvious and grounded in a similar manner to the statement and mathematical notation of Newton’s third law of motion in texts on physics for students of secondary schools and technical universities:
“The force with which two bodies act upon each other are equal in magnitude and opposite in direction”:
where F1 is the force with which body 1 acts on body 2 and F2 is the force with which body 2 acts on body 1.
Laws of heat radiation from gas volumes possess the compactness and the accuracy of the description of physical phenomena in a similar manner to the fundamental laws of physics. For example, a fundamental law of physics, Ohm’s law, describes the relationship between the current I flowing in the conductor and the voltage U applied to the conductor and the conductor resistance R:
Similarly, the law of heat radiation from gas volumes characterizes the dependence of flux density of heat radiation q of gas volume from the angular coefficient of the radiation φ, radiated power P, and the average beam path length rays l of gas volume. For the calculation of parameters of heat radiation from gas volumes (6) φ, P, and l analytical expressions, formulas were derived [16, 17, 18, 19].
A unique, natural harmony of heat radiation from quadrillions of particles of spherical and cylindrical gas volumes is disclosed, namely, that the average beam path length from these particles is equal to the arithmetic mean distance from the symmetry axis of volumes to the calculated area.
Complex, a triple integration of no solution within the gas volume to determine the average beam path length is reasonably replaced by computing actions of elementary mathematics and analytic geometry; this produces the same result, which would have been gotten in triple integration.
The uniqueness of the scientific discovery is that the flux densities of radiation and angular radiation coefficients of spherical, coaxial, and cylindrical gas volumes to the calculated area are equal and it is sufficient to hold a single integration of trigonometric functions within the height of the cylindrical gas volume of a small diameter, located on the axis of symmetry to define them [15, 16, 17, 18, 19, 20, 21, 22].
Heat radiation from cylindrical gas volumes of diameter 2, 5, and 10 m and more in calculations can be equivalently modeled by heat radiation from cylindrical gas volumes of an infinitely small diameter and the axis of their symmetry. Scientific discovery of heat radiation from gas volumes provides researchers and designers with great opportunities for improvement of electric arc and torch furnaces, fireboxes, and combustion chambers.
With the discovery and development of the laws of geometrical, physical, and mathematical models of torch, the radiating gas volumes and torches as sources of heat radiation become an investigated physical phenomenon, not a “black box.” The formulas for calculating the density of the radiation flux from the gas volume, the torch on the calculation area (6), for determining the local angular coefficients of gas volumes on the calculation area [15, 16, 17, 18, 19, 20, 21, 22], for determining the mean path length of quadrillion rays (2) from gas volumes on the calculation area were obtained. Basing on the scientific discoveries of the laws of heat radiation from gas volume, the theory of thermal radiation from the gas volume and the new concept of calculating heat transfer in torch furnaces, fire chambers, and combustion chambers were developed [19]. The theory of thermal radiation of the gas volume includes the output 14 of the formulas for calculating the coefficients and fluxes of the radiation of the flame on the heating surface in Vivarelli, mutually perpendicular coils and arbitrarily located planes.
In accordance with the new concept and the theory, cylinder gas volumes, from which the calculation of radiation fluxes on the calculated areas and heating surface is performed, are inscribed in torches.
Radiation fluxes from torch, heated surfaces, and combustion products are determined for each calculated area taking into account multiple reflections and torch for each calculated area platform determined by taking into account multiple reflections and absorptions. The calculations of heat transfer in steam boiler boxes [9, 10, 18, 19, 20], torch heating furnaces [7, 8, 15, 16, 17], and combustion chambers of gas turbine installations [19] are made with the use of the new concept.
The calculations allow to determine rational energy modes of electric arc and torch furnaces, fireboxes, and combustion chambers in which fuel consumption reduces and operational life increases. In 15 years since the first publication of the author of scientific discovery in printing, the theory of thermal radiation of the gas volume and the new concept of calculating heat transfer in torch furnaces, fire chambers, and combustion chambers have been tested by time; the results of calculations are confirmed by the results of experimental studies on existing kilns, furnaces, and combustion chambers; and the accuracy of calculations does not exceed 10%. Since the radiation laws of a blackbody and the laws of Stefan-Boltzmann and Planck, these wines belong to the fundamental laws of physics, and the laws of radiation by gas volumes are both fundamental laws of physics.
The laws of heat radiation, the theory of heat radiation from gas volumes, and the new concept of calculation in electric arc and torch furnaces, fire boxes, and combustion chambers were published in the form of text [19], which is used for teaching university students. The method for calculation that had existed until the scientific discovery had not allowed to calculate and to manage rational heat transfer in torch furnaces, since the error of calculations was 20–50%, so the efficiency of fuel energy in torch furnaces is 25–45% at the present time. The use of scientific discovery and its base-developed theory allows to determine the rational parameters of the torch (capacity, length, expansion angle) and its spatial position to the heating surface (vertical, horizontal, inclined at a certain angle).
Rational position of products and torches and burners will increase consumption efficiency of fuel energy half-twofold from 25–45 to 65–75% and decrease fuel consumption twofold over the coming years all over the world.
A unified procedure for calculating heat transfer in electric arc and torch furnaces, fireboxes, and combustion chambers has been developed proceeding from the discovered regularities pertinent to heat transfer in torch gas layers [19]. The resulting integral heat fluxes consisting of radiant fluxes falling on the heating surfaces from the torch, wall and arch lining, combustion products, and convective fluxes are all calculated according to this procedure. Innovative designs of torch furnaces and fireboxes have been developed proceeding from the discovered regularities, and the use of which makes it possible to obtain a higher output from fireboxes, more uniform steam generation in tubes, more uniform heating of articles, and smaller consumption of fuel.
The distribution of integral radiant fluxes over the boiler firebox walls and bottom surfaces was calculated taking the TGMP_204 boiler as an example used as part of a 800 MW power unit, and the firebox of which has the shape of a rectangular parallelepiped of height
The distribution of temperature along the height of steam boiler fireboxes was investigated [23, 24, 25]; the results of temperature measurements are reported in many publications, e.g., in [12]. The torch fills the entire firebox chamber and has the shape of a straight elliptical cylinder; the isotherms shown in Figure 4 divide it along the height into six volume bodies.
Five volume bodies with ellipses in their bases and vertices and with a parabolic generatrix (the torch vertical parts) have the shape of elliptical paraboloids resting on the sixth volume body having the shape of a truncated ellipsoid of revolution (the horizontal part of torch 7).
The own radiation from gas volumes and the radiation power decrease along the firebox height in accordance with temperature variation along the flame height. Below, we denote the power releasing in the flame horizontal part by
where Qri is the fuel heating value equal to 41 MJ/kg and
Introducing the assumption that the radiating volumes are isothermal within the confines of their volume zones and taking into account that the volume bodies have identical bases and different heights, we can write the following proportion for determining the power releasing in each of the six volume zones:
where
The following values of powers releasing in the torch volume zones were obtained from expression (10): MW:
For calculating the integral radiation fluxes falling from the torch on the waterwall surfaces and for reducing the calculation error, the torch should be decomposed as follows: three straight circular cylinders are inscribed into the straight elliptical cylinder representing the torch vertical part (see Figure 3) and these circular cylinders will model the radiation from the flame vertical part both over its height and volume, i.e., over the firebox width and depth. The way in which the radiation fluxes from the cylinder are distributed over the heating surface does not depend of the cylinder diameter; therefore, the torch vertical part should be subdivided into 15 small-diameter cylinders representing linear radiation sources by 3 in each vertical volume zone.
Schematic design of the regenerative soaking pit with a two-tier unit of regenerators (a) and the distribution of integral heat fluxes falling on the lateral surfaces facing the soaking pit longitudinal symmetry axis over the ingot height (b). (
After that, we determine the density of integral radiation flux from each
where
The density of incident integral radiation flux from the torch on the
The distribution of integral radiation fluxes falling on the front and rear walls of a TGMP-204 steam boiler firebox is almost the same and is characterized by curves
Distribution of the integral radiation flux density over the walls (a) and bottom (b) of the TGMP-204 boiler firebox. (
The maximal integral radiation fluxes are observed on the front and rear walls at a height of 12–16 m (4–5 m above the top tier of burners). The waterwall surfaces at a height of 12–16 m experience the maximal radiation from the horizontal volume zone and from the torch’s first vertical volume zone. The densities of integral radiation fluxes reach here 780 kW/m2 on the front and rear walls and 520 kW/m2 on the lateral walls. The integral radiation fluxes observed on the walls at the firebox bottom level are a factor of 1.7–1.9 smaller and equal to 460 and 270 kW/m2, respectively. This is because the wall lower belt is located at a considerable distance away from the first vertical volume zone and the more so from the second to the fifth volume zones. The density of integral radiation fluxes falling from the torch on areas lying at a height of above 20 m decreases along the wall height in a similar manner.
The densities of integral radiation fluxes on the walls under the ceiling are equal to 150 and 110 kW/m2, respectively, on the front and lateral walls along the vertical symmetry axis. Such decrease of integral radiation fluxes on the wall surfaces under the ceiling is due to the fact that the wall upper belt is situated at a considerable distance away from the torch horizontal and first vertical volume zones, in which 72% of the torch power is released, whereas only around 10% of the torch power is released in the nearby fourth and fifth vertical volume zones.
The variation of integral radiation flux densities over the wall perimeter is also essentially nonuniform in nature. The densities of integral fluxes radiated from the torch in the front and rear wall “hot belt” situated at a height of 12–16 m vary from 780 kW/m2 at the wall vertical symmetry axis to 180 kW/m2 at their periphery; i.e., they drop by a factor of 4.3. This is because the vertical symmetry axes of the front and rear walls are situated at the shortest distances from the linear sources and from the central and peripheral cylinders by which the torch is modeled.
The densities of integral fluxes radiated from the torch at the vertical symmetry axis and at the periphery of lateral walls differ from each other to a significantly lesser extent. The densities of integral fluxes radiated from the torch at a height of 12–16 m are equal to 520 and 290 kW/m2, respectively, at the vertical symmetry axis and at the periphery of lateral walls. The flux densities in the underceilng zone of lateral walls differ from each other to a still lesser extent and are equal to 120 and 95 kW/m3, respectively, at the vertical symmetry axis and at the periphery. This is because the distance from the cylindrical sources of radiation to the vertical symmetry axis of lateral walls differs insignificantly from the similar distance to the periphery of lateral walls [19].
Figure 4b shows the calculated distribution of integral radiation flux densities over the bottom surface. The 250 kW/m2 isorad forms an elliptic hot spot in the bottom surface center with the sizes along the major and minor axes equal to 12 and 8 m. The integral radiation fluxes at the bottom periphery do not exceed 125 kW/m2.
As is well known [23], the surface density of deposits inside the tubes increases with the density of integral radiation flux falling on the waterwall surfaces. With a heat flux equal to 200 kW/m2, the surface density of deposits inside the tubes is 0.1 kg/m2, whereas at 500 kW/m2, it is equal to 0.3 kg/m2; that is, the density of deposits inside the tubes grows in proportion to the heat flux. Hence, reducing the densities of integral heat fluxes and making them more uniform over the perimeter and height of steam boiler firebox walls are presently a topical problem.
An experimental confirmation of the results obtained from the performed calculations aimed at determining the distribution of integral radiation flux densities over the surfaces of the TGMP-204 steam boiler firebox can be found in [1], as well as in [24, 25].
In [19], the experimentally determined distribution of integral radiation fluxes over the height of the left-hand lateral waterwall of a TGMP-204 KhL steam boiler firebox is presented for the case of boiler operation in the mode of power unit maximal load equal to 800–820 MW1. The difference between the maximal local incident radiation fluxes in the firebox of a TGMP-204 steam boiler obtained by calculation (780 kW/m2) and by measurements (870 kW/m2) [25] does not exceed 12%, which confirms that the developed torch mathematical model adequately reflects the real conditions.
Nonuniform distribution of the densities of integral fluxes radiated from the torch over the wall perimeters and heights gives rise to similar nonuniformity of steam generation and deposits in the tubes. Engineers who develop and design steam boilers, as well as researchers in this field, should apply additional efforts on improving the designs of fireboxes aimed at decreasing the heat fluxes over the wall perimeters and heights and at making them more uniform, which will lead to similar reduction and more uniform distribution of deposits in the tubes. The shortcoming of the considered firebox of a TGMP-204 boiler is that the waterwall heating surfaces in the furnace lower part experience high heat loads, which result in a high growth rate of deposits inside the tubes. High heat loads entail a growth of temperature of waterwall tube metal surfaces and facilitate the occurrence and development of high-temperature corrosion in these surfaces. All the abovementioned factors have a negative effect on the service life of waterwall heating surfaces and, hence, result in less reliable operation of the entire boiler.
The use of the proposed calculation procedure allows one to get a more comprehensive idea about heat transfer and to design new improved fireboxes for steam boilers. This improvement is achieved through changing the shape of firebox and waterwall surfaces and the inclination angle of oppositely arranged burners, which leads to rational distribution of heat loads [26, 27].
In [27], a firebox for firing gas and oil fuel was proposed. This firebox consists of a bottom, arch, walls, waterwalls repeating the firebox inner surface, and oppositely placed burners built in the walls. The firebox is made in the form of two truncated cones with their larger bases facing each other. The firebox bottom serves as the base of the lower cone; the lateral walls of the upper cone are matched with vertical walls forming the shape of a straight cylinder. The burners are inclined to a horizontal plane at an angle of 5–10°.
Figure 5 shows the innovative firebox of a TGMP-204-I steam boiler with rational distribution of heat loads intended for use as part of an 800 MW power unit. This furnace has the form of two truncated hexagonal pyramids with a common base having the shape of a regular hexagon with a radius of 9.6 m. The firebox is fitted with 36 vortex double-flow burners with a throughput of 5.2 t/h each. The burners are installed in three tiers uniformly over the perimeter of walls at the corners and in the middle of each face of the lower inverted pyramid. The firebox has a height of 46 m, and its volume is approximately equal to that of the TGMP-204 steam boiler. The air excess factor in the TGMP-204-I boiler firebox α = 1.03, the gas recirculation ratio
Firebox of the TGMP-204-I steam boiler (the dashed line in view
Figure 5 shows the expected distribution of temperature over the height of the TGMP-204-I boiler firebox. Owing to the sloped walls, the firebox has a larger volume in the zone of burners; the maximal expected temperature in the active fuel combustion zone is 1600°C, and the temperature of combustion products leaving the firebox chamber is 1300°C. The torch is modeled by a vertical cylinder with five volume zones and by 12 inclined cylinders (Figure 5). The torch power
Distribution of integral radiation flux density over the walls of the TGMP-204-I boiler furnace.
Owing to the fact that all waterwall surfaces and all faces of the truncated pyramid are situated at the same distance from the torch and from the cylindrical
sources of radiation by which the torch is modeled, the integral radiation flux density along the wall symmetry axis and at the wall periphery is characterized by one curve shown in Figure 6. The integral radiation flux density has the same distribution over all waterwall surfaces and over all faces of the upper and lower truncated pyramids. The heat flux density in the zone of maximal heat loads at a height of 12–16 m in the TGMP-204-I boiler firebox is by 200 kW/m2 lower than it is in the TGMP-204 boiler firebox. As a result, more uniform steam generation is obtained in all tubes of waterwall surfaces over the firebox perimeter.
Owing to lower heat loads, the waterwalls operate at lower temperature, which result in a lower rate of their corrosion. This, in turn, results in a longer service life of waterwall heating surfaces and in a longer interval between their outages for cleaning the boiler with acid.
The proposed design of the steam boiler firebox has also other advantages over the existing ones. The new firebox has a larger volume in its part opposite to the burners, and the torch has a lower temperature in this volume, which results in less intense generation of nitrogen oxides. In addition, the waterwall surfaces in the firebox upper part are situated closer to the torch axis, due to which the working fluid absorbs heat more intensely and the heat fluxes are distributed along the firebox height more uniformly (see Figure 6). It is expected that the formation of deposits inside the tubes will be less intense in the proposed steam boiler firebox, that its operational costs will be reduced, that the firebox will have higher efficiency, and that the waterwall surfaces and working fluid will absorb heat more intensely [26].
Comparison between the distribution pattern of integral radiation fluxes over the TGMP-204 boiler firebox walls and that of the TGMP-204-I boiler firebox with the similar capacity testifies that the latter has certain advantages over the former: the heat loads of the waterwall surfaces are more uniformly distributed over the firebox height, the maximal heat loads in the burner zone are decreased by 25%, the torch has a lower temperature, and a smaller amount of nitrogen oxides is generated.
Here, we examine calculations of heat transfer in the furnace of a type TGMP-314 steam boiler with modeling of the flare by radiative zones and large cylindrical gas volumes.
The TGMP-314 steam boiler furnace for a 300 MW power-generating unit is in the shape of a rectangular parallelepiped (Figure 7a, b) with height
A type TGMP-314 steam boiler furnace with modeling of the flare by radiating cylindrical volumes: (a) distribution of isotherms and cylindrical radiation sources, (b) dividing the furnace into large cylindrical radiating volumes, and (c) the distribution of the integrated radiative flux along the height of the front and side walls: (
Figure 7c shows the calculated radiative fluxes incident on the shielding surfaces of the furnace walls of a TGMP-314 steam boiler furnace. The distribution of the integrated radiative flux along the vertical axis of symmetry of the front wall is characterized by graph 1, which also illustrates the distribution of the integrated radiative flux along the vertical axis of symmetry of the rear wall.
The measured and calculated integrated radiative fluxes along the vertical axis of symmetry of the front wall differ by less than 10% [28, 29]. This confirms the adequacy of the model developed here for the flare in type TGMP-314 steam
boiler furnaces. The maximum heat release zone, located at a height of 2–5 m from the bottom of the furnace, is characterized by maximal integrated radiative fluxes of the flare onto the front and rear walls at a level of 680 kW/m2. At heights of 2–5 m on the side walls, the radiative fluxes along the axis of symmetry are 590 kW/m2; at a distance of 2 m from the axis of symmetry, they fall to 440 kW/m2.
On the periphery of the front wall at a height of 2–5 m, the radiative fluxes from the flare fall to 250 kW/m2. The heat release in the flare decreases along the height of the furnace; the integrated radiative fluxes of the flare on the shielding surfaces also decrease.
The nonuniform distribution of the radiation fluxes from the flare along the perimeter and height of the screen surfaces of the walls gives rise to similar nonuniformity of vaporization and deposits in the tubes [2, 3]. The high heat loads in the bottom part of the front and back walls increase the temperature of the screen tubes and promote high-temperature corrosion in them. As a result of this, the problem of lowering the maximum temperature of the flare and equalizing the radiation flux densities on the screen surfaces along the height and perimeter of the firebox walls of steam boilers is of high priority. The importance of finding a solution to this problem also increases because the temperature in the fuel combustion zone affects thermal nitrogen oxide NOx emissions the most [30].
An innovative modification of the shape of the firebox of a steam boiler was proposed in order to obtain a rational distribution of the heat loads along the screen surfaces and to reduce nitrogen oxide emissions. The bottom part remains a rectangular parallelepiped; it is expedient to make the top part (Figure 8a) a truncated four-sided pyramid [26].
Firebox of TGMP-314 steam boiler with innovative modification: (a) distribution of the isotherms and cylindrical sources of radiation which are used to model the flare (same as in
We shall examine heat transfer in such a firebox for the example of the previously studied boiler of the TGMP-314 power plant [19]. To suppress nitrogen oxide and organize two-step combustion of fuel, the nozzles are installed to feed air in amounts of 16 units (8 units per tier at heights 5.5 and 11 m). Oil is fed into a burner with air deficiency á = 0.8–0.85; the remaining air required for complete combustion of the fuel equals Äá = 0.2–0.25 and is fed through a nozzle higher up on the flare. The implementation of the two-step combustion of the fuel makes it possible to lower the temperature of the flare in the active burn zone and the nitrogen oxide emissions by 25–60%.
In order that the implementation of two-step combustion of fuel not to increase the temperature of the combustion products at the outlet of the firebox, the radiative heat transfer was organized from the flare to the screen surfaces in the middle and top parts of the firebox. To this end, the front, back, and side walls are built to slope at 4–6° relative to the vertical axis starting from the height 15 m, forming a truncated pyramid of height hp. = 20 m. The walls converge onto the axis of the flare, the radiative heat transfer from the flare to the screen surfaces increases, the heat fluxes along the height of the screen surfaces equalize, and the temperature of the flare decreases. The expected distribution of the temperatures in the firebox of a TGMP-314 steam boiler modernized in this manner is shown in Figure 8. As a result of the two-step combustion of fuel, the temperature in the zone of active combustion decreases to 1750°C. As a result of the improvement of the radiative heat transfer, the temperature of the combustion products leaving the firebox does not exceed 1300°C with the walls converging on the flare. The heat transfer in the modernized firebox of the TGMP-314 steam boiler was calculated.
The computational results obtained from expression (12) are displayed in Figure 8b. It is evident that the highest values of the maximum radiation flux densities—546 kW/m2—lie on the front walls at 10 m on the vertical axis. The radiation flux densities on the vertical axis of the front and side walls equal 352 and 306 kW/m2, respectively, at a height of 18 m, 246 and 205 kW/m2 at 24 m, and 175 and 148 kW/m2 at 30 m. Comparing the radiation flux densities of the flare along the screen surfaces of the front side in the fireboxes of conventional and modernized TGMP-314 boilers (Figure 8b) shows that in the firebox of the modernized boiler the highest radiation flux densities on the screen surface decreased by 24% from 680 to 546 kW/m2 in the bottom part, increased by 40% from 252 to 352 kW/m2 at height 18 m, and increased by 47% from 167 to 246 kW/m2. In the top part at height 30 m, the heat fluxes from the flare in the firebox of the modernized boiler increased by 41% compared with the conventional boiler: from 126 to 178 kW/m2. Similar variation of the radiation flux density distributions also occurs along the height of the screen surfaces of the side walls.
Altering the configuration of the firebox of a steam boiler from a rectangular parallelepiped in the bottom part to a truncated rectangular four-sided pyramid whose walls incline at angle 5–6° to the vertical plane inside the firebox in the central and top parts made it possible to increase the heat fluxes on their screen surfaces and reduce the no uniformity of the heat flux distribution along the height and perimeter of the firebox.
These changes ease the operating conditions of the tubes in the bottom part, lower the maximum gas temperatures in the interior volume of the firebox and the gas temperature at the exit from the firebox, reduce the production of nitrogen oxides in the firebox, and increase the service life of the screens.
The scientific discovery of the laws and the development of the theory of heat radiation from gas volumes is a contribution to the foundation of modern physics, as it allows calculating and managing the transfer of heat around the world in tens of thousands of electric arcs and torch furnaces, steam boiler boxes, and combustion chambers of gas turbine units, reducing energy consumption and saving millions of tons of fuel, reducing emissions of pollutants and anthropogenic load on the environment, and improving the quality of life in many countries. The laws and the theory of heat radiation of the ionized and non-ionized gas volumes and the laws of Makarov were included in the text [19], in the amount of fundamental knowledge on the quantum nature of radiation, and are in line with the laws of heat radiation from absolutely black body and with even more than 30 fundamental laws of physics.
The use of both light and heat in medicine has roots that reside long back in history. In ancient times, sunlight was used to treat different kinds of skin and mental diseases. These treatments mimic, amplify, and in some cases focus on natural occurring phenomena to achieve a therapeutic goal.
\nDuring the nineteenth century, it was observed that prolonged heating, as fever or locally externally induced hyperthermia, could cause cancerous formations to disappear [1, 2, 3, 4]. Since then, many methods to treat cancer with heat were introduced, from whole body to local methods such as microwave ablation, radiofrequency ablation, and laser ablation. The main goals with innovative treatments that utilize heat are to give an alternative to patients that are not suitable for surgery and minimize the impact of the intervention on the patient. In addition, many of these methods have a lower economical impact on the treating institution budget, which enables clinics to offer treatment to a larger number of patients.
\nOther methods that do not make use of heat as treating source were also developed, such as cryogenic ablation that uses subfreezing temperatures to kill the tumor cells or photodynamic therapy (PDT) that uses a selective combination of light and photoactivatable drugs to induce radicals in the tumor.
\nInterest in focal ablation of tumors increased significantly in the last decades because of indications that local treatment may cause shrinkage of untreated, in some cases distant, tumors suggesting the involvement of the immune system in the process [5, 6, 7]. The so-called abscopal effect evoked by local treatments could be used to treat patients that lack effective treatments to date. Immune stimulating interstitial laser thermotherapy is an innovative hyperthermia treatment that uses a specifically tailored treatment protocol based on lower temperature heating for a prolonged period of time and designed to maximize the probability of triggering the immune system response to the treated tumor type. The medical device system uses laser as heat source; the same system is also used for interstitial laser ablation to burn tumorous and non-tumorous formation when imaging is challenging given its natural MR compatibility.
\nLaser-based hyperthermia, known as laser thermotherapy or laser ablation, is a focal hyperthermia technique that uses laser light as heat source. Its minimally invasive version for treatment of tumors located deeper in the body is called interstitial laser thermotherapy (LITT or ILT). The main goal in oncological treatments is to achieve tumor destruction without damaging tissue and structures surrounding the neoplastic lesion to be treated. Different factors concur to the tissue destruction, among these direct cell death and coagulation.
\nDuring laser-induced thermotherapy, light causes damage in tissue due to absorption of light and through heat conduction into the tissue of the absorbed energy. Laser thermotherapy therefore produces a lesion that is larger than the volume where light is absorbed due to this heat conduction.
\nThese two phenomena, direct light absorption and heat conduction, determine the modality and the parameters to be used to control the tumor heating and are dependent on the characteristics of the tissue to be treated.
\nThe penetration depth, which is defined as the distance at which the light is attenuated to 1/
Penetration depth depends on the tissue type since the optical properties are dependent on tissue composition and structure. For a generic tissue composition, the effective attenuation coefficient and the penetration depth can be calculated as follows:
\nValues for
The absorption,
Absorption spectra of tissue components in the window 500–1100 nm. Dotted line at 1064 nm.
The scattering,
Scattering coefficient for a generic soft tissue in the window 500–1100 nm, data from literature. Dotted line at 1064 nm.
The equation takes into consideration different scattering contributions mainly due to the different sizes of the scattering centers.
\nAll the parameters are tissue dependent. The values for a generic soft tissue in Table 1 were used in Figure 2.
\ng | \n0.95 | \n
a′ [cm−1] | \n19.1 | \n
fRay | \n0.153 | \n
bMie | \n1.091 | \n
Scattering parameters for a generic tissue [9].
The energy deposited in tissue causes an increase in temperature in the portion of tissue where laser light is absorbed. Naturally, the difference in heat evens out over time. The heat is removed from the volume where absorption of light occurs by active or passive cooling. Active cooling is achieved through blood perfusion, which varies during time according to response of the tissue to heat and is dependent on the perfusion rate and therefore on the tissue type. Passive cooling is due to heat conduction and is described by the second law of thermodynamics which asserts that heat flows spontaneously from hot to cold bodies, in this case from the heated portion of tissue to the portion of tissue at body temperature.
\nIf the delivered energy is high enough, the heat conduction concurs to the progression of the damage since heat conduction can cause tissue temperatures to rise well above the threshold for permanent damage. The threshold for permanent tissue damage is discussed in the following paragraphs.
\nPennes’ equation models heat distribution in the tissue:
\nThe equation describes the heat flow in the tissue as the combination of (passive) heat conduction, (active) heat transport due to blood perfusion and dependent on the temperature difference, metabolic heat source which is the heat produced by the tissue itself, and the external heat source, in this case the laser energy [10, 11, 12].
\nEffects on biological tissues induced by lasers can vary in nature and can be classified in several groups among which are photochemical damage, when light triggers a chemical reaction in the tissue, and thermal effects, when heat is the cause of the outcome. Photochemical damage includes radical formation and tissue inflammation, while examples of thermal damage are protein denaturation and burning. The type of damage triggered depends mainly on the characteristics of the light beam (wavelength, power, pulse properties, exposure time, spot size) and if the beam is collimated, i.e., laser source.
\nThermal effects are caused when the temperature in the tissue is locally increased over the physiological temperature; the threshold is generally set to 40°C. Conditional to the specific tissue properties, beam characteristics and exposure times, the tissue can undergo hyperthermia (<60°C), coagulation, vaporization, carbonization, or pyrolysis. Hyperthermia can be reversible or irreversible depending on the combination of temperature reached and exposure time. Local ablation techniques, such as microwave, radiofrequency, or laser ablation, aim at achieving a temperature of at least 60°C in the whole treated volume, therefore inducing cell death by coagulation; vaporization and carbonization may occur.
\nClassic laser ablation is used to treat solid tumor masses in a variety of organs and aims at heating the whole tumor volume at a temperature of at least 60°C in order to coagulate the tissue in the area to be treated. In this way, near to instant cell death is achieved. An optical fiber is placed in the center of the region of interest, and light is delivered for a period of time of 1–10 minutes depending on the volume to ablate and the device used. The treatment can be repeated directly after to achieve larger coagulation volume either inserting the fiber in a new position or utilizing the so-called pull-back technique, meaning performing a new ablation along the insertion track by pulling the fiber back.
\nImmune stimulating interstitial laser thermotherapy (imILT) is a local ablation method that works at non-coagulating temperatures at the tumor border. The technique consists in creating a temperature gradient in the tumor that results in a heating to 46°C at the tumor border or some millimeters outside it. The temperature is then kept for a prolonged period of approximately 30 minutes to achieve an immunogenic cell death (ICD) at the tumor border, visible only 48–72 hours after treatment, which activates an immune response [13, 14]. An example of ablation achieved performing an imILT treatment is shown in Figure 3. The biological process is not fully understood to date, but the hypothesis is that imILT creates inflammation in the tumor. Damage-associated molecular pattern (DAMP) signal is created, and antigens, which are not coagulated due to the low temperatures, are released [7, 15, 16, 17]. The antigens are picked up by antigen-presenting cells (APCs) that in turn trigger an immune response [18, 19, 20, 21].
\nEffect of imILT treatment on porcine healthy skeletal muscle tissue. Coagulation is achieved within the yellow circle, and immunogenic cell death (ICD) is achieved along the ablation border, between the yellow and the blue line.
The method can in principle be used to treat all types of solid tumors, but some types will be more responsive than others depending on the tumor biology, which is true for immunotherapies in general. Some results from proof-of-concept preclinical and clinical studies are presented in this chapter.
\nThe CE-marked and FDA-approved TRANBERG® Thermal Therapy System for imILT consists of three main parts: a laser generator, a laser applicator, and a thermometry system. The laser generator is a diode-based system that emits light at a wavelength of 1064 nm and with a maximum accessible power of 25 W continuous wave. The unit has a built-in temperature feedback system that is able to measure the temperature in the tissue by means of a minimally invasive temperature probe and to drive the laser emission in order to maintain a stable temperature, set by the user between 43 and 50°C, for a treatment time of up to 30 minutes. The laser applicator consists of a non-cooled optical fiber and an introducer to enable insertion of the fiber in the tissue. The non-cooled optical fiber is available in different tip designs tailored to the ablation volume and shape to be achieved and the tissue to be treated.
\nAll the procedures are performed under image guidance, using MRI, ultrasound, computed tomography (CT), or a combination of the previous depending on the availability of these techniques at the clinic. While it is only possible to perform imILT treatments using ultrasound or CT guidance due to limitations in the temperature probe design, the design of the laser applicator allows laser ablation procedure to be performed with MRI guidance, for example, when performing a focused laser ablation (FLA) for the treatment of early prostate cancer or benign prostatic hyperplasia (BPH).
\nExtensive preclinical studies were performed to prove the immune stimulating effects of imILT. One specific study aimed at comparing the immunologic memory evoked by imILT if compared to resection [22].
\nResearch was conducted on 280 rats divided in four groups: (1) rats with tumor implanted in the liver that were treated with imILT, (2) rats with tumors implanted in the liver that were treated with surgical resection, (3) rats without tumor that were treated with imILT ablating normal liver tissue (sham imILT), and (4) rats without tumors that were treated with resection of a part of a healthy liver (sham resection).
\nRats in groups 1 and 2 were implanted with adenocarcinoma and treated after 6–8 days. A second challenging tumor of the same kind was implanted in another lobe 2, 5, or 10 weeks later, and the animals were followed for up to 48 days after rechallenge unless they showed signs of inactivity or distress earlier. Vital tumor at sacrifice was evaluated together with other immune system markers. Group 1, tumor treated with imILT, showed a distinct behavior if compared with the other three groups. In groups 2, 3, and 4, the challenging tumor, second implanted, displayed a growth so substantial that none of the rats survived for 48 days. On the contrary, rats in group 1 showed eradication of the challenging tumor at day 48. The extent of the tumor burden for the four groups is represented in Figure 4. These findings, combined with results from immunology markers from blood tests, indicate that imILT invokes a strong immune response and an immunologic memory against the treated cancer.
\nTumor burden after implantation of challenging tumor. Only rats having been treated with imILT of primary tumor survived for 48 days after implantation of challenging tumor. All other rats in the 48-day study group had to be euthanized within 10–30 days after the tumor challenge due to extensive tumor. Image: Mats Ekelund.
A number of pre-marketing clinical studies on imILT were performed at Lund University Hospital, Lund, Sweden, where the method was developed for the first time. These studies demonstrated the recruitment of immunocompetent cells in breast cancer patients which indicate a favorable antitumor activity [23, 24, 25, 26, 27].
\nMore recently, initial findings from the clinical study program designed to evaluate the safety and the usability of the method performed using the TRANBERG®|Thermal Therapy System (Clinical Laserthermia Systems, AB, Sweden) were published [28]. A variety of solid tumors are included in the study program; the data was reported after 12 patients were treated, out of which 4 were female and 8 were male. Indications treated were breast cancer (n = 1), breast cancer metastasis (n = 1), colon cancer metastasis (n = 2), malignant melanoma metastasis (n = 2), pancreatic carcinoma (n = 1), and primary pancreatic carcinoma (n = 5); the latter two were treated in open surgery, while the other percutaneously. All the treatments were performed using CT or ultrasound guidance. All patients included in the study underwent numerous previous treatments due to comorbidity. Immunotherapy was delivered on two malignant melanoma patients before imILT treatment but not during the study period.
\nOne serious adverse event was reported out of nine patients within the sponsor initiated clinical study; the frequency of serious adverse events is in line with previous data on other local ablative techniques, including laser ablation [29, 30], indicating that the procedure can be safely performed.
\nUsability results vary among the different study clinics. Preliminary indications suggest that insertion and placement of the instrumentation within the volume to be treated are the main challenge, while sterile access, removal from the tissue, and handling of disposable are perceived as less complicated. Handling of the laser unit needs further investigation as the data is spread [28].
\nThe safety studies were not designed to collect statistically significant efficacy results. Each study included different indications to gather safety data and input to future efficacy studies as extensive as possible leading to a low number of patients per indication, and therefore no indication-based data was published. Future ongoing publications will include indicative efficacy and quality-of-life results from these studies.
\nThis case is a 53-year-old patient with pancreatic cancer diagnosed about 2 years before and treated with first-line chemotherapy, FOLFIRINOX 16 cycles, for tumor reduction. Disease progression was registered after 12 cycles. Due to intolerable toxicity, the treatment regimen was changed to second- and third-line chemotherapies, gemcitabine and protein-bound paclitaxel 16 cycles, after which partial response was achieved. At the time of the first imILT treatment 2 years after the diagnosis, the patient presented with pancreatic carcinoma and three liver metastases (stage IV). PET-CT showed a hypermetabolic focus around the biliary stent, but no clearly visible tumor in the pancreas, and three metastases in the liver (segments VI, V/VI, and V/peri-gallbladder area).
\nThe first treatment was performed on a 19 mm liver metastasis in segment VI that was metabolically active; see Figure 5. The intervention was performed percutaneously under CT guidance, and a first treatment was performed by placing the tip of the radial laser applicator in the metastasis—see Figure 6—and a temperature needle at a distance of approximately 10 mm. The temperature needle was used to regulate the laser emission based on the measured temperature and achieve ICD in a region of the lesion that presented as metabolically active from the PET scan. A temperature of 44–45°C was kept during a period of 30 minutes according to the imILT protocol. A second overlapping ablation was performed after repositioning the laser applicator to necrotize the whole volume of the metastasis. Track ablation was performed to minimize risk for track seeding of tumor cells along the insertion track. A post-procedure CT scan was performed to ensure the ablation of the entire tumor, which was achieved as shown in Figure 7 (black arrow). The patient suffered slight pain and rise in temperature (38°C) posttreatment, but no other discomfort was registered; the patient was discharged after 3 days. No complications were reported during the first 3 months following therapy [31].
\nPET-CT (left) and CT (right) scans showing the position of the treated metastasis during the first treatment session [
Laser applicator positioning visualized using CT scan while placing the instrumentation for the first treatment [
Posttreatment CT that shows the ablation cavity (black arrow) and the biliary stent (white arrow). First treatment session [
Partial response in liver metastasis and total response in pancreas primary tumor were registered 21 months later. However, 3 months later disease progression was noticed, and the patient was treated with imILT for a second time 24 months after the initial treatment. The targeted metastasis was a 35 × 50 mm liver metastasis evaluated at ultrasound at the time of the treatment. The metastasis was treated performing one imILT treatment combined with an overlapping LITT treatment of about 5 minutes to necrotize the whole metastatic mass; the imILT treatment was achieved positioning the radial laser applicator off center within the tumor and the temperature probe at a distance of approximately 11 mm from the applicator. The temperature measured by the probe was kept at 43–45°C for 20 minutes.
\nLastly, a third imILT treatment was performed after 40 months from the first treatment because of new disease progression. A new 20 mm liver metastasis was treated using a diffuser laser applicator combined with an introducer with built-in temperature sensors, which resulted in only one puncture. The laser applicator was inserted in the center of the metastasis, and the sensors were positioned 25 mm from the applicator tip to achieve a lesion of 25–30 mm in diameter. To date, 4 months after the last treatment, no complications connected to the laser treatment have been reported [32].
\nLocal ablation of tumors is receiving increasing attention for the treatment of metastatic disease because of observed effects on distant tumorous masses suggesting the involvement of the immune system following local therapy.
\nOne technique for local tumor eradication is laser ablation which kills the tumor mass by heating the tissue through direct light absorption and heat transfer resulting in tissue coagulation. imILT is an interstitial laser ablation method tailored to evoke an immune response against the treated tumor. The technique utilizes a laser applicator to deliver energy in the form of laser light to the tissue; the energy delivered to the tissue is precisely controlled based on the temperature measured by a sensor inserted in the tissue at the periphery of the tumor to obtain a lower temperature ablation that aims at maximizing the immune cell death (ICD) volume of the ablation.
\nPreclinical results indicate that imILT invokes an immune response against the treated tumor, if compared with resection in a rat tumor model. Clinical studies suggest that the procedure can be safely performed since the frequency of the adverse events is in line with previous data on other local ablation techniques. The case of a pancreatic cancer patient treated with imILT was presented.
\nThis publication was founded and made possible by Clinical Laserthermia Systems AB, Lund, Sweden.
\nCristina Pantaleone is the Technical Manager of Product Development at Clinical Laserthermia Systems, AB.
\nI would like to thank Belarmino Gonçalves for the pictures relative to the case report and Karin Peterson, Gunilla Savring, Emily Emilsson Rossander, Maria Luisa Verteramo, and Dennis Laks for review and support.
\n\n absorption coefficient scattering coefficient anisotropy factor scaling factor that equals the reduced scattering coefficient at 500 nm fraction of Rayleigh scattering scattering power (Mie scattering) tissue density blood density tissue thermal conductivity tissue heat capacity blood heat capacity blood perfusion rate difference between the heated tissue and the blood or the surrounding tissue metabolic heat external heat sources benign prostate hyperplasia damage associated molecular pattern computed tomography immunogenic cell death interstitial laser thermotherapy immune stimulating interstitial laser thermotherapy laser-induced thermotherapy photodynamic therapy
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All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. 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This chapter reviews the results of 20 PTSD clinical trials funded by the United States Department of Defense and Department of Veterans Affairs on the treatment of combat-related PTSD. All of the studies were conducted under the leadership and management of two research consortia: the South Texas Research Organizational Network Guiding Studies on Trauma and Resilience (STRONG STAR) Consortium and the Consortium to Alleviate PTSD.",book:{id:"9563",slug:"current-topics-on-military-medicine",title:"Current Topics on Military Medicine",fullTitle:"Current Topics on Military Medicine"},signatures:"Alan L. Peterson, Barbara L. Niles, Stacey Young-McCaughan and Terence M. Keane",authors:[{id:"340047",title:"Prof.",name:"Alan L.",middleName:null,surname:"Peterson",slug:"alan-l.-peterson",fullName:"Alan L. Peterson"},{id:"345787",title:"Prof.",name:"Barbara L.",middleName:null,surname:"Niles",slug:"barbara-l.-niles",fullName:"Barbara L. 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This is followed by a modified theoretical framework, M-31000, taking into account OHS risk management practice. The results of 42/149 key informants selected as part of a purposive sampling strategy identified three main advantages of ISO 31000, including acting as a good starting point for risk management, supplementing other risk management strategies, and allowing for easier integration with other similar strategies. The two main shortfalls identified in this pilot included the standard being vague and difficult to implement. The study also revealed that M-31000 was much simpler and more consistent with safety management practice.",book:{id:"6480",slug:"occupational-health-and-safety-a-multi-regional-perspective",title:"Occupational Health and Safety",fullTitle:"Occupational Health and Safety - A Multi-Regional Perspective"},signatures:"Manikam Pillay",authors:[{id:"199145",title:"Dr.",name:"Manikam",middleName:null,surname:"Pillay",slug:"manikam-pillay",fullName:"Manikam Pillay"}]}],mostDownloadedChaptersLast30Days:[{id:"71988",title:"Introductory Chapter: Safety and Health for Workers - Theory and Applications",slug:"introductory-chapter-safety-and-health-for-workers-theory-and-applications",totalDownloads:827,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"7620",slug:"safety-and-health-for-workers-research-and-practical-perspective",title:"Safety and Health for Workers",fullTitle:"Safety and Health for Workers - Research and Practical Perspective"},signatures:"Bankole K. 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Nevertheless, the recent changes of the labor market underline that new risks to the health and well-being of workers should be considered. In this context, a vast amount of studies have analyzed the relationship between work conditions, social inequalities, and health, suggesting a complex net of causation. Only recently, it has been shown that people in lower socioeconomic positions incur higher working risks. The 2008–2013 economic crisis also introduced a reduction of the number of workers in full-time permanent employment with a steady expansion of atypical and precarious workers. The latter have generally been associated with more insecure and unhealthy working conditions. Another important aspect of safety in the workplace is gender differences. Although nowadays there is more information than before about the types of health problems and accidents women incur at the workplace, the gender-related questions are still open issues that require a careful evaluation of work-related risks of men and women. In this chapter, we focused on the current state of the art in the field of occupational health and examined the aspects that are still being debated.",book:{id:"7620",slug:"safety-and-health-for-workers-research-and-practical-perspective",title:"Safety and Health for Workers",fullTitle:"Safety and Health for Workers - Research and Practical Perspective"},signatures:"Anna Maria Giammarioli",authors:[{id:"175022",title:"Dr.",name:"Anna Maria",middleName:null,surname:"Giammarioli",slug:"anna-maria-giammarioli",fullName:"Anna Maria Giammarioli"}]},{id:"72308",title:"Hand Hygiene Practices in Public Restrooms: Effects and Proposed Solutions",slug:"hand-hygiene-practices-in-public-restrooms-effects-and-proposed-solutions",totalDownloads:994,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Human safety is a popular ongoing research area in personal hygiene. Researchers are mostly apprehensive about how to protect humans from different hazards in the environment. Thus, guidelines developed for good hand wash practices in the public restrooms have showed little or no impact on human behavior. This research examined hand wash acts in the public restrooms and proposed possible solutions to improve the practice. There are 427 people who participated in the study. Participant age ranged from 18 years old and upward: statistically, female, 63%; male, 35%; and unidentified, 2%. Descriptive statistics revealed 99.5% respondents approved restroom redesign for appropriate hand hygiene practice, while 49% suggested restroom device automation. Inferential statistics results on redesign with a Welsh t-test were statistically significant (t=1.967, df=300, p<0.0001; t=1.990, df=80, p<0.0001; t=1.9746, df=163, p<0.0001). Findings showed that hand hygiene guidelines and recommendations are insufficient to ensure proper promotion of hand wash practices in restrooms. This study concluded that good hand wash practices in public restrooms could be ergonomically redesigned to include a visual and auditory alert that reminds users to wash their hands after restroom usage and to include hand wash practice in school curriculum. The findings from this study could be applicable in restaurants, schools, and bars, to manage and control transmission of disease through direct hands contacted with infectious diseases in the restrooms.",book:{id:"7620",slug:"safety-and-health-for-workers-research-and-practical-perspective",title:"Safety and Health for Workers",fullTitle:"Safety and Health for Workers - Research and Practical Perspective"},signatures:"Bankole K. Fasanya, Moruf Adegbite, Maged Mikhail and George L. 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Dr. Bobek is also a co-founder of the Academy of Regional Management in Slovenia.",institutionString:"Universities of Applied Sciences FH Joanneum, Austria",institution:null},editorTwo:{id:"293992",title:"Dr.",name:"Tatjana",middleName:null,surname:"Horvat",slug:"tatjana-horvat",fullName:"Tatjana Horvat",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hXb0hQAC/Profile_Picture_1642419002203",biography:"Tatjana Horvat works as a professor for accountant and auditing at the University of Primorska, Slovenia. She is a Certified State Internal Auditor (licensed by Ministry of Finance RS) and Certified Internal Auditor for Business Sector and Certified accountant (licensed by Slovenian Institute of Auditors). 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She specializes in the subject of brands, brand equity, and brand management in production, service, and trade enterprises. She combines this subject with marketing and marketing management in both theoretical and practical aspects. Prof. Hanna Górska-Warsewicz also analyzes brands in the context of trademarks, legal regulations and the protection of intangible. She is an author or co-author of over 200 publications in this field, including 8 books. She works with the business sector and has participated in projects for the Ministry of Agriculture and Rural Development and the Ministry of Education and Science in Poland.",institutionString:null,institution:{name:"Warsaw University of Life Sciences",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:45,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. Udoh, Josephine U. 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Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. 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He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. 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He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. 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She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. 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Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"38",type:"subseries",title:"Pollution",keywords:"Human activity, Pollutants, Reduced risks, Population growth, Waste disposal, Remediation, Clean environment",scope:"
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11966,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null,series:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713"},editorialBoard:[{id:"252368",title:"Dr.",name:"Meng-Chuan",middleName:null,surname:"Ong",slug:"meng-chuan-ong",fullName:"Meng-Chuan Ong",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRVotQAG/Profile_Picture_2022-05-20T12:04:28.jpg",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",institutionURL:null,country:{name:"Malaysia"}}},{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}},{id:"187907",title:"Dr.",name:"Olga",middleName:null,surname:"Anne",slug:"olga-anne",fullName:"Olga Anne",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBE5QAO/Profile_Picture_2022-04-07T09:42:13.png",institutionString:null,institution:{name:"Klaipeda State University of Applied Sciences",institutionURL:null,country:{name:"Lithuania"}}}]},onlineFirstChapters:{paginationCount:6,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. 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